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About 179,000 results

The neuropsychiatry of tinnitus: a circuit-based approach to the causes and treatments ...
https://doi.org/10.1136/jnnp-2013-307339
Journal of Neurology, Neurosurgery, and Psychiatry; Minen MT, Camprodon J et. al.

Apr 19th, 2014 - Patients presenting with tinnitus commonly have neuropsychiatric symptoms with which physicians need to be familiar. We provide an overview of tinnitus, including its types and pathophysiology. We discuss how recent methods such as transcranial magnetic stimulation, positron emission tomography, MRI, magnetoencephalography and quantitative EEG improve our understanding of the pathophysiology of...

Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698790
JAMA Hsieh MM, Fitzhugh CD et. al.

Jul 24th, 2014 - Myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) is curative for children with severe sickle cell disease, but toxicity may be prohibitive for adults. Nonmyeloablative transplantation has been attempted with degrees of preparative regimen intensity, but graft rejection and graft-vs-host disease remain significant. To determine the efficacy, safety, and outcome on end-orga...

Practice guidelines for the diagnosis and management of skin and soft tissue infections...
https://doi.org/10.1093/cid/ciu296
Clinical Infectious Diseases : an Official Publication Of... Stevens DL, Bisno AL et. al.

Jun 20th, 2014 - A panel of national experts was convened by the Infectious Diseases Society of America (IDSA) to update the 2005 guidelines for the treatment of skin and soft tissue infections (SSTIs). The panel's recommendations were developed to be concordant with the recently published IDSA guidelines for the treatment of methicillin-resistant Staphylococcus aureus infections. The focus of this guideline is...

Pediatric mycosis fungoides in Singapore: a series of 46 children.
https://doi.org/10.1111/pde.12352
Pediatric Dermatology; Heng YK, Koh MJ et. al.

Jun 3rd, 2014 - Few studies have evaluated Asian children with mycosis fungoides (MF). We report a series of patients from a tertiary dermatologic institution in Singapore. A retrospective review was performed of patients younger than 16 years old diagnosed with MF between 2000 and 2008 at the National Skin Centre, Singapore. Forty-six patients were identified. At initial presentation, a provisional diagnosis ...

Multicenter pilot treatment trial for psychogenic nonepileptic seizures: a randomized c...
https://doi.org/10.1001/jamapsychiatry.2014.817
JAMA Psychiatry; LaFrance WC, Baird GL et. al.

Jul 5th, 2014 - There is a paucity of controlled treatment trials for the treatment of conversion disorder, seizures type, also known as psychogenic nonepileptic seizures (PNES). Psychogenic nonepileptic seizures, the most common conversion disorder, are as disabling as epilepsy and are not adequately addressed or treated by mental health clinicians. To evaluate different PNES treatments compared with standard...

Transplantation outcomes for severe combined immunodeficiency, 2000-2009.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183064
The New England Journal of Medicine; Pai SY, Logan BR et. al.

Jul 30th, 2014 - The Primary Immune Deficiency Treatment Consortium was formed to analyze the results of hematopoietic-cell transplantation in children with severe combined immunodeficiency (SCID) and other primary immunodeficiencies. Factors associated with a good transplantation outcome need to be identified in order to design safer and more effective curative therapy, particularly for children with SCID diag...

Review article: the management of portal hypertensive gastropathy and gastric antral va...
https://doi.org/10.1111/apt.12824
Alimentary Pharmacology & Therapeutics; Patwardhan VR, Cardenas A

Jun 3rd, 2014 - Portal hypertensive gastropathy (PHG) and gastric antral vascular ectasia (GAVE) are important causes of both acute and chronic gastrointestinal bleeding in patients with cirrhosis. To review the current management of PHG and GAVE. PubMed was searched for English language articles using the key words 'GAVE', 'gastric antral vascular ectasia', 'cirrhosis', 'gastrointestinal bleeding', 'acute', '...

Vulvar cancers in women with vulvar lichen planus: a clinicopathological study.
https://doi.org/10.1016/j.jaad.2014.05.057
Journal of the American Academy of Dermatology; Regauer S, Reich O et. al.

Jul 7th, 2014 - Vulvar squamous cell carcinomas (SCCs) arising in association with vulvar lichen planus (LP) are poorly documented. We sought to present clinicopathological features of 38 patients (median age 61 years, range 39-90 years) with LP-associated vulvar SCCs. Evaluated were location of vulvar SCC and metastases at presentation, recurrences, survival, precursor lesions, presence of human papillomaviru...

Treatment-resistant bipolar depression: a randomized controlled trial of electroconvuls...
https://doi.org/10.1176/appi.ajp.2014.13111517
The American Journal of Psychiatry; Schoeyen HK, Kessler U et. al.

Sep 15th, 2014 - Electroconvulsive therapy (ECT) is regarded by many clinicians as the most effective treatment for treatment-resistant bipolar depression, but no randomized controlled trials have been conducted, to the authors' knowledge. They compared efficacy measures of ECT and algorithm-based pharmacological treatment in treatment-resistant bipolar depression. This multicenter, randomized controlled trial ...

Dietary elimination therapy is an effective option for adults with eosinophilic esophag...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102669
Clinical Gastroenterology and Hepatology : the Official C... Wolf WA, Jerath MR et. al.

Jan 20th, 2014 - Eosinophilic esophagitis (EoE) is an immune-mediated disorder. Food elimination is an established treatment for children, but data in adults are limited. We aimed to determine the response of adults with EoE to dietary therapy. This was a retrospective cohort study using the University of North Carolina EoE database from 2006 to 2012. Subjects were age 18 and older, had EoE by consensus guideli...

Chimeric antigen receptor T cells for sustained remissions in leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267531
The New England Journal of Medicine; Maude SL, Frey N et. al.

Oct 15th, 2014 - Relapsed acute lymphoblastic leukemia (ALL) is difficult to treat despite the availability of aggressive therapies. Chimeric antigen receptor-modified T cells targeting CD19 may overcome many limitations of conventional therapies and induce remission in patients with refractory disease. We infused autologous T cells transduced with a CD19-directed chimeric antigen receptor (CTL019) lentiviral v...

Simvastatin in the acute respiratory distress syndrome.
https://doi.org/10.1056/NEJMoa1403285
The New England Journal of Medicine; McAuley DF, Laffey JG et. al.

Sep 30th, 2014 - Studies in animals and in vitro and phase 2 studies in humans suggest that statins may be beneficial in the treatment of the acute respiratory distress syndrome (ARDS). This study tested the hypothesis that treatment with simvastatin would improve clinical outcomes in patients with ARDS. In this multicenter, double-blind clinical trial, we randomly assigned (in a 1:1 ratio) patients with an ons...

Autologous transplantation and maintenance therapy in multiple myeloma.
https://doi.org/10.1056/NEJMoa1402888
The New England Journal of Medicine; Palumbo A, Cavallo F et. al.

Sep 3rd, 2014 - This open-label, randomized, phase 3 study compared melphalan at a dose of 200 mg per square meter of body-surface area plus autologous stem-cell transplantation with melphalan-prednisone-lenalidomide (MPR) and compared lenalidomide maintenance therapy with no maintenance therapy in patients with newly diagnosed multiple myeloma. We randomly assigned 273 patients 65 years of age or younger to h...

Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associate...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455597
Journal of Clinical Oncology : Official Journal of the Am... Kochenderfer JN, Somerville RPT et. al.

Mar 15th, 2017 - Purpose T cells genetically modified to express chimeric antigen receptors (CARs) targeting CD19 (CAR-19) have potent activity against acute lymphoblastic leukemia, but fewer results supporting treatment of lymphoma with CAR-19 T cells have been published. Patients with lymphoma that is chemotherapy refractory or relapsed after autologous stem-cell transplantation have a grim prognosis, and new...

Stereotactic body radiotherapy vs. TACE or RFA as a bridge to transplant in patients wi...
https://doi.org/10.1016/j.jhep.2017.02.022
Journal of Hepatology; Sapisochin G, Barry A et. al.

Mar 4th, 2017 - There is limited information on the use of stereotactic body radiotherapy (SBRT) as a bridge to liver transplantation for hepatocellular carcinoma and no study comparing its efficacy to transarterial chemoembolization (TACE) and radiofrequency ablation (RFA). We aimed to ascertain the safety and efficacy of SBRT on an intention-to-treat basis compared with TACE and RFA as a bridge to liver tran...

Long-term results and recurrence patterns from SCALOP: a phase II randomised trial of g...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482737
British Journal of Cancer; Hurt CN, Falk S et. al.

Apr 4th, 2017 - SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. Eligibility: histologically proven LAPC ⩽7 cm. Following 12 weeks of induction GEMCAP chemotherapy (three cycles: GEM 1000 mg m-2 days 1, 8, 15; CAP 830 mg m-2 days...

Potentially Curable Pancreatic Cancer: American Society of Clinical Oncology Clinical P...
https://doi.org/10.1200/JCO.2017.72.4948
Journal of Clinical Oncology : Official Journal of the Am... Khorana AA, Mangu PB et. al.

Apr 11th, 2017 - Purpose To update the Potentially Curable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline published on May 31, 2016. The October 2016 update focuses solely on new evidence that pertains to clinical question 4 of the guideline: What is the appropriate adjuvant regimen for patients with pancreatic cancer who have undergone an R0 or R1 resection of their primar...

Liver and combined lung and liver transplantation for cystic fibrosis: analysis of the ...
https://doi.org/10.1111/j.1399-3046.2010.01460.x
Pediatric Transplantation; Arnon R, Annunziato RA et. al.

Jan 11th, 2011 - A proportion of patients with CF develop cirrhosis and portal hypertension. LT and combined LLT are rarely performed in patients with CF. To determine the outcome of LT and LLT in patients with CF. Patients with CF who had LT or LLT between 10/1987 and 5/2008 were identified from UNOS database. A total of 182 children (<18 yr) and 48 adults underwent isolated LT for CF. Seven more children and ...

Guidelines for the management of vitiligo: the European Dermatology Forum consensus.
https://doi.org/10.1111/j.1365-2133.2012.11197.x
The British Journal of Dermatology; Taieb A, Alomar A et. al.

Aug 6th, 2012 - The aetiopathogenic mechanisms of vitiligo are still poorly understood, and this has held back progress in diagnosis and treatment. Up until now, treatment guidelines have existed at national levels, but no common European viewpoint has emerged. This guideline for the treatment of segmental and nonsegmental vitiligo has been developed by the members of the Vitiligo European Task Force and other...

Small bowel bacterial overgrowth in adults: a potential contributor to intestinal failure.
https://www.ncbi.nlm.nih.gov/pubmed/18377796
Current Gastroenterology Reports; Ziegler TR, Cole CR

Apr 1st, 2008 - Small bowel bacterial overgrowth (SBBO), in which colon-derived bacteria colonize the upper small bowel, is found in a wide variety of adult diseases associated with intestinal failure and dysfunction, including short bowel syndrome and other conditions following massive bowel resection, dysmotility disorders, and inflammatory bowel disease. SBBO also appears to be relatively common in the elde...