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About 182,428 results

Cytomegalovirus-Specific T Cells from Third-Party Donors Successfully Treated Refractor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681565
Journal of Immunology Research; Li N, Sun G et. al.

Nov 26th, 2022 - Umbilical cord blood (UCB) transplants (UCBTs) are becoming increasingly common in the treatment of a variety of hematologic and nonhematologic conditions. The T cells from UCB are naïve T cells, which have not yet been exposed to antigens and therefore do not contain T cells with specific immune functions against viruses. Cytomegalovirus (CMV) infections occur in more than 80% of patients afte...

Convalescent or standard plasma versus standard of care in the treatment of COVID-19 pa...
https://doi.org/10.1186/s12879-022-07716-5
BMC Infectious Diseases; Manzini PM, Ciccone G et. al.

Nov 25th, 2022 - The efficacy of early treatment with convalescent plasma in patients with COVID-19 is debated. Nothing is known about the potential effect of other plasma components other than anti-SARS-CoV-2 antibodies. To determine whether convalescent or standard plasma would improve outcomes for adults in early phase of Covid19 respiratory impairment we designed this randomized, three-arms, clinical trial ...

Positive Association of Plasma Trimethylamine-N-Oxide and Atherosclerosis in Patient wi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649308
Cardiovascular Therapeutics; Kong W, Ma J et. al.

Nov 25th, 2022 - Atherosclerosis is the major cause of acute coronary syndrome (ACS) which is a significant contributor to both morbidity and mortality in the world. The microbiome-derived metabolite trimethylamine-N-oxide (TMAO) has aroused great interest and controversy as a risk factor of atherosclerosis. Therefore, in this study, we aimed at investigating whether plasma TMAO can be a risk factor of atherosc...

Atrial-His bundle pacing in fulminant myocarditis with ventricular arrhythmia: a case r...
https://doi.org/10.1186/s12872-022-02936-8
BMC Cardiovascular Disorders; Jiang L, Wang L et. al.

Nov 25th, 2022 - Fulminant myocarditis is a clinical syndrome associated with threatening dysrhythmia which temporary pacemaker can be used for life-saving support. As a method of physiological pacing, His bundle pacing (HBP) maintain better cardiac synchronization than traditional right ventricular (RV) pacing. It's a severe case of fulminant myocarditis in a 41-year-old patient who presented for recurrent arr...

Cognitive-behavioral therapy on psychological stress and quality of life in subjects wi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686076
BMC Public Health; Zuo X, Dong Z et. al.

Nov 25th, 2022 - Anxiety and depression are two common psychological disorders in patients with pulmonary tuberculosis. We aimed to explore the effects of cognitive-behavioral therapy (CBT) on psychological stress and quality of life in patients with pulmonary tuberculosis. From September 2018 to November 2018, 20 communities (461 participants in total) were randomly assigned in an intervention or control group...

Homogenizing effect of PEEP on tidal volume distribution during neurally adjusted venti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685871
Respiratory Research; Widing H, Chiodaroli E et. al.

Nov 25th, 2022 - The physiological response and the potentially beneficial effects of positive end-expiratory pressure (PEEP) for lung protection and optimization of ventilation during spontaneous breathing in patients with acute respiratory distress syndrome (ARDS) are not fully understood. The aim of the study was to compare the effect of different PEEP levels on tidal volume distribution and on the ventilati...

Transcatheter Treatment of Mitral Regurgitation in Cardiogenic Shock: Promises and Pitf...
https://doi.org/10.1016/j.jacc.2022.09.028
Journal of the American College of Cardiology; Lurz P, Besler C

Nov 25th, 2022 - Transcatheter Treatment of Mitral Regurgitation in Cardiogenic Shock: Promises and Pitfalls.|2022|Lurz P,Besler C,|diagnosis,etiology,surgery,etiology,therapy,surgery,

Cardiovascular Disease in Large Vessel Vasculitis: Risks, Controversies, and Management...
https://doi.org/10.1016/j.rdc.2022.08.004
Rheumatic Diseases Clinics of North America; Clifford AH

Nov 25th, 2022 - Takayasu's arteritis (TAK) and giant cell arteritis (GCA) are the 2 most common primary large vessel vasculitides (LVV). They share common vascular targets, clinical presentations, and histopathology, but target a strikingly different patient demographic. While GCA predominantly affects elderly people of northern European ancestry, TAK preferentially targets young women of Asian heritage. Cardi...

Biomarkers in Testicular Cancer: Classic Tumor Markers and Beyond.
https://doi.org/10.1016/j.ucl.2022.09.002
The Urologic Clinics of North America; Egan J, Salari K

Nov 25th, 2022 - Biomarkers play a key role in patients with testicular germ cell tumors in a variety of clinical contexts, including initial diagnosis, prognostication, monitoring treatment response, and posttreatment surveillance. Although the classic serum tumor markers for testicular germ cell tumors are essential for clinical management, the low sensitivity (particularly for seminoma and teratoma) and pote...

Current and Future Biomarkers in the Management of Renal Cell Carcinoma.
https://doi.org/10.1016/j.ucl.2022.09.003
The Urologic Clinics of North America; Reese S, Calderon L et. al.

Nov 25th, 2022 - Renal cell carcinoma biomarkers include serum, urine, liquid, and tissue biomarkers. There is currently an ongoing search for predictive biomarkers in the detection, recurrence, and treatment of renal cell carcinoma. Emerging signatures in the transcriptomic and translational biomarker space seem promising, although additional work is needed to validate candidates in a larger and more generaliz...

Challenges of cell therapies for retinal diseases.
https://doi.org/10.1016/bs.irn.2022.09.004
International Review of Neurobiology; Christelle M, Lise M et. al.

Nov 25th, 2022 - Because retinal cells could not regenerate in mammals, retinal degeneration is an irreversible phenomenon caused by various disease conditions including age-related macular degeneration (AMD) and retinitis pigmentosa (RP). During the course of these diseases, photoreceptors (PRs) are susceptible to degenerate due to their malfunctions or to a primary dysfunction of the retinal pigment epitheliu...

Costs associated with retinopathy of prematurity: a systematic review and meta-analysis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693652
BMJ Open; Gyllensten H, Humayun J et. al.

Nov 25th, 2022 - To review and analyse evidence regarding costs for retinopathy of prematurity (ROP) screening, lifetime costs and resource use among infants born preterm who develop ROP, and how these costs have developed over time in different regions. Systematic review and meta-analysis DATA SOURCES: PubMed and Scopus from inception to 23 June 2021. Included studies presented costs for ROP screening and the ...

Autologous hematopoietic stem cell transplantation improves long-term survival-data fro...
https://doi.org/10.1186/s13075-022-02948-x
Arthritis Research & Therapy; Blank N, Schmalzing M et. al.

Nov 25th, 2022 - Current recommendations on the management of systemic sclerosis (SSc) suggest that autologous hematopoietic stem cell therapy (HSCT) can be a rescue therapy for patients with rapidly progressive SSc. To assess the safety and efficacy of HSCT for patients with SSc and to compare these with non-HSCT patients in a control cohort with adjusted risk factors. A retrospective analysis of data from the...

Cellular nanomechanics derived from pattern-dependent focal adhesion and cytoskeleton t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694872
Journal of Nanobiotechnology; Wang Y, Wang N et. al.

Nov 25th, 2022 - Gene transfection was supposed to be the most promising technology to overcome the vast majority of diseases and it has been popularly reported in clinical applications of gene therapy. In spite of the rapid development of novel transfection materials and methods, the influence of morphology-dependent nanomechanics of malignant osteosarcoma on gene transfection is still unsettled. In this study...

Torn between two worlds: parental experiences of neonatal follow-up for infants with hy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693659
BMJ Open; Chandrasekaran SA, John HB et. al.

Nov 25th, 2022 - This study aimed to understand the barriers and facilitators of a neonatal follow-up programme, as perceived by parents of infants born with hypoxic ischaemic encephalopathy (HIE). This study applied a qualitative study design using interpretative phenomenological analysis. It included focus group discussions, face-to-face in-depth interviews and telephonic interviews. Data were analysed using ...

Elevated Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio after First Cy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689285
Current Oncology (Toronto, Ont.); Tseng RH, Lai KM et. al.

Nov 25th, 2022 - Background: Prognostic factors for poor survival have been proposed in esophageal squamous cell carcinoma (SCC) patients receiving concurrent chemoradiotherapy (CCRT). We conducted a retrospective study on hematological profile after first cycle of chemotherapy for esophageal SCC patients receiving CCRT. Methods: From January 2008 to December 2017, a total of 420 patients with esophageal SCC we...

Stereotactic Radiotherapy after Incomplete Transarterial (Chemo-) Embolization (TAE\TAC...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689962
Current Oncology (Toronto, Ont.); Comito T, Loi M et. al.

Nov 25th, 2022 - Background: Hepatocellular carcinoma (HCC) is the most frequent liver malignancy and a leading cause of cancer death in the world. In unresectable HCC patients, transcatheter arterial (chemo-) embolization (TAE/TACE) has shown a disease response in 15-55% of cases. Though multiple TAE/TACE courses can be administered in principle, Stereotactic Body Radiotherapy (SBRT) has emerged as an alternat...

The neurogenic bladder: developing a consensus bladder and bowel management pathway for...
https://doi.org/10.12968/bjon.2022.31.21.1088
British Journal of Nursing (Mark Allen Publishing); Thomas S, Bradley J et. al.

Nov 24th, 2022 - This article outlines how the bladder can be affected in neurological conditions such as multiple sclerosis (MS) and the impact this has on patient quality of life and NHS resources. A group of MS and bladder and bowel nurse specialists has developed consensus bladder pathways in the hope that all nurses in contact with patients who are likely to have neurogenic bladder symptoms become 'bladder...

Hematologic and Oncologic Emergencies.
https://doi.org/10.1097/CNQ.0000000000000440
Critical Care Nursing Quarterly; Holden K, Rao S et. al.

Nov 24th, 2022 - This article reviews both hematologic and oncologic emergencies that may be seen in the intensive care setting. Hematologic emergencies, including autoimmune hemolytic anemia, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, and disseminated intravascular coagulation, as well as oncologic emergencies including tumor lysis syndrome, superior vena cava syndrome, and cardiac tampona...

Preliminary efficacy of cognitive-behavioral therapy on emotion regulation in adults wi...
https://doi.org/10.1371/journal.pone.0277398
PloS One; Kuroda M, Kawakubo Y et. al.

Nov 24th, 2022 - Previous studies have demonstrated the clinical utility of cognitive-behavioral therapy in improving emotion regulation in children on the autism spectrum. However, no studies have elucidated the clinical utility of cognitive-behavioral therapy in improving emotion regulation in autistic adults. The aim of the present pilot study was to explore the preliminary clinical utility of a group-based ...