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About 12,133 results

War journalism: an occupational exposure.
https://doi.org/10.1136/bcr-2021-245165
BMJ Case Reports; Magnavita N, Congedo MT et. al.

Oct 16th, 2021 - Apart from the risk of accidents, war theatres present a hazard related to numerous long-lasting toxic agents. For 10 years, a >60-year-old male journalist worked in war theatres in the Far and Near East where he was exposed to asbestos and other toxic substances (metals, silica, clays, polycyclic aromatic hydrocarbons and other organic substances) contained in dust and smoke of destroyed build...

A Review of Treatment Options in CLL
https://www.onclive.com/view/a-review-of-treatment-options-in-cll

Oct 7th, 2021 - Carrie Lenneman, MD, MSCI: Hello, and thank you for joining this OncLive® webinar titled: Updates in CLL: A Closer Look at Adverse Events. I’m Carrie Lenneman, an associate professor at and the director of cardio-oncology program at the University of Alabama at Birmingham. I’m joined by Dr. Farrukh Awan, an associate professor in the department of internal medicine and the director of the lymph...

Dr. Sborov on Managing Bispecific Antibody–Related Adverse Effects in Multiple Myeloma
https://www.onclive.com/view/dr-sborov-on-managing-bispecific-antibody-related-adverse-effects-in-multiple-myeloma

Oct 6th, 2021 - Douglas W. Sborov, MD, MS, assistant professor, Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, University of Utah School of Medicine; director, Multiple Myeloma Program and Division of Hematology Biorepository; member, Huntsman Cancer Institute (HCI) Experimental Therapeutics Program; physician leader, Multiple Myeloma/Bone Marrow Transplant arm, HCI Clini...

Dr. Sperling on Managing CAR T-Cell Therapy–Related Toxicities in Multiple Myeloma
https://www.onclive.com/view/dr-sperling-on-managing-car-t-cell-therapy-related-toxicities-in-multiple-myeloma

Oct 6th, 2021 - Adam Sperling, MD, PhD, a physician at the Dana-Farber Cancer Institute, and an instructor in medicine at Harvard Medical School, discusses managing CAR T-cell therapy–related toxicities in multiple myeloma. Managing cytokine release syndrome (CRS) and neurotoxicity is a challenge in multiple myeloma, says Sperling. However, the experience with CAR T-cell therapy in lymphoma and leukemia has...

Protective Effect of Isopulegol in Alleviating Neuroinflammation in Lipopolysaccharide-...
https://doi.org/10.1615/JEnvironPatholToxicolOncol.2021038944
Journal of Environmental Pathology, Toxicology and Oncolo... Kang B, Li N et. al.

Sep 30th, 2021 - Parkinson's disease (PD) is the most prevalent disease linked with age-associated neuronal degeneration. Phytotherapeutic compounds or agents have gained increased importance because of their increased specificity and minimal side effects. Isopulegol, a monoterpene, was utilized in the present study because of its wide range of therapeutic properties. Our aim was to examine the underlying mecha...

Mechanisms of Ethanol-Induced Cerebellar Ataxia: Underpinnings of Neuronal Death in the...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391842
International Journal of Environmental Research and Publi... Mitoma H, Manto M et. al.

Aug 28th, 2021 - Ethanol consumption remains a major concern at a world scale in terms of transient or irreversible neurological consequences, with motor, cognitive, or social consequences. Cerebellum is particularly vulnerable to ethanol, both during development and at the adult stage. In adults, chronic alcoholism elicits, in particular, cerebellar vermis atrophy, the anterior lobe of the cerebellum being hig...

Lactobacillus paracasei R3 protects against dextran sulfate sodium (DSS)-induced coliti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371868
Journal of Translational Medicine; Huang J, Yang Z et. al.

Aug 20th, 2021 - Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis (UC) and Crohn's Disease, are most often a polygenic disorder with contributions from the intestinal microbiome, defects in barrier function, and dysregulated host responses to microbial stimulation. Strategies that target the microbiota have emerged as potential therapies and, of these, probiotics have gained the greatest ...

Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365894
Journal of Translational Medicine; Cheng D, Xu Q et. al.

Aug 18th, 2021 - Silicosis is one of the most common occupational pulmonary fibrosis caused by respirable silica-based particle exposure, with no ideal drugs at present. Metformin, a commonly used biguanide antidiabetic agent, could activate AMP-activated protein kinase (AMPK) to exert its pharmacological action. Therefore, we sought to investigate the role of metformin in silica-induced lung fibrosis. The anti...

Sex-related Differences in Glial Fibrillary Acidic Protein-positive GABA Regulate Neuro...
https://doi.org/10.1016/j.neuroscience.2021.08.002
Neuroscience Hong GP, Kim MH et. al.

Aug 18th, 2021 - Status epilepticus (SE) is a life-threatening neurological disorder that causes neuronal death and glial activation. Studies have explained the clinical side effects and lack of effectiveness of neurological disorder treatments based on sex-related differences in brain structure and function. However, the sex-specific outcomes of seizure disorders and the underlying mechanisms remain unknown. W...

Paradoxical effects of arsenic in the lungs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364060
Environmental Health and Preventive Medicine; Ren C, Zhou Y et. al.

Aug 15th, 2021 - High levels (> 100 ug/L) of arsenic are known to cause lung cancer; however, whether low (≤ 10 ug/L) and medium (10 to 100 ug/L) doses of arsenic will cause lung cancer or other lung diseases, and whether arsenic has dose-dependent or threshold effects, remains unknown. Summarizing the results of previous studies, we infer that low- and medium-concentration arsenic cause lung diseases in a dose...

Effect of Environmental Pollutants PM2.5, CO, NO2, and O3 on the Incidence and Mortalit...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345586
International Journal of Environmental Research and Publi... Meo SA, Abukhalaf AA et. al.

Aug 8th, 2021 - In recent decades, environmental pollution has become a significant international public problem in developing and developed nations. Various regions of the USA are experiencing illnesses related to environmental pollution. This study aims to investigate the association of four environmental pollutants, including particulate matter (PM2.5), carbon monoxide (CO), Nitrogen dioxide (NO2), and Ozon...

Biological synthesis, characterization of three metal-based nanoparticles and their ant...
https://doi.org/10.1016/j.ecoenv.2021.112575
Ecotoxicology and Environmental Safety; Younas M, Rizwan M et. al.

Aug 6th, 2021 - Treatment of liver cancer has always been a challenge for clinicians and development of appropriate drug against hepatocellular carcinoma is the major focus for researchers working in the field. The synthesis of metal-based nanoparticles (NPs) by green method for pharmacological uses has attained considerable attention recently. In current study three different NPs (AgO2, CeO2, CuO2) were synth...

A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456165
American Journal of Human Genetics; Xu M, Mehl L et. al.

Aug 4th, 2021 - Genome-wide association studies (GWASs) have identified a melanoma-associated locus on chromosome band 7p21.1 with rs117132860 as the lead SNP and a secondary independent signal marked by rs73069846. rs117132860 is also associated with tanning ability and cutaneous squamous cell carcinoma (cSCC). Because ultraviolet radiation (UVR) is a key environmental exposure for all three traits, we invest...

Host Bioenergetic Parameters Reveal Cytotoxicity of Antituberculosis Drugs Undetected U...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448146
Antimicrobial Agents and Chemotherapy; Cumming BM, Baig Z et. al.

Aug 3rd, 2021 - High attrition rates in tuberculosis (TB) drug development have been largely attributed to safety, which is likely due to the use of endpoint assays measuring cell viability to detect drug cytotoxicity. In drug development for cancer, metabolic, and neurological disorders and for antibiotics, cytotoxicity is increasingly being assessed using extracellular flux (XF) analysis, which measures cell...

A Novel Therapeutic Peptide Blocks SARS-CoV-2 Spike Protein Binding with Host Cell ACE2...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319882
Drugs in R&D; Rajpoot S, Ohishi T et. al.

Jul 30th, 2021 - Coronavirus disease 2019 is a novel disease caused by the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 virus. It was first detected in December 2019 and has since been declared a pandemic causing millions of deaths worldwide. Therefore, there is an urgent need to develop effective therapeutics against coronavirus disease 2019. A critical step in the crosstalk between the virus and...

Increased Risk of Gastric Cancer in Asbestos-Exposed Workers: A Retrospective Cohort St...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303218
International Journal of Environmental Research and Publi... Fang YJ, Chuang HY et. al.

Jul 25th, 2021 - Asbestos has been recognized as a human carcinogen associated with malignant mesothelioma, cancers of lung, larynx, and ovary. However, a putative association between gastric cancer and asbestos exposure remains controversial. In this study, we aimed to explore gastric cancer risk of workers potentially exposed to asbestos in Taiwan. The asbestos occupational cohort was established from 1950 to...

Quantitation of Silica Contents in Lung Explants of Transplanted Patients: Artificial S...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304914
International Journal of Environmental Research and Publi... Fireman E, Mahamed AE et. al.

Jul 25th, 2021 - Spectrophotometric techniques provide qualitative but not quantitative data on lung particles. We aimed to quantitate silica content in biopsies of lung-transplanted silicosis patients by applying X-ray fluorescence (XRF) spectrometry. Lung biopsies of 17 lung-transplanted artificial patients were quantitated for silica and other minerals particles by Niton XL3 XRF spectrometry. Occupational an...

Arsenic trioxide induces expression of BCL-2 expression via NF-κB and p38 MAPK signalin...
https://doi.org/10.1016/j.ecoenv.2021.112531
Ecotoxicology and Environmental Safety; Tang J, Yao C et. al.

Jul 25th, 2021 - Inorganic arsenic compounds are environmental toxicants that are widely distributed in air, water, and food. B-cell lymphoma 2 (BCL-2) is an oncogene having anti-apoptotic function. In this study, we clarify that BCL-2, as a pro-apoptotic factor, participates in As2O3-induced apoptosis in BEAS-2B cells. Specifically, As2O3 stimulated the expression of BCL-2 mRNA and protein in a dose-dependent ...

The combinations of sulfur and molybdenum fertilizations improved antioxidant capacity ...
https://doi.org/10.1016/j.ecoenv.2021.112520
Ecotoxicology and Environmental Safety; Li Y, Wang Y et. al.

Jul 20th, 2021 - Mineral development and metal smelting are the main sources of heavy metal pollution, and copper (Cu) and cadmium (Cd) are the most serious mineral elements in heavy metal pollution. Food chain is the main channel for Cu and Cd to enter human body. Excessive accumulation of Cu and Cd can lead to a variety of diseases and threaten human health. Therefore, it is urgent to repair Cu and Cd-contami...

Levamisole, a cocaine cutting agent, induces acute and subchronic systemic alterations ...
https://doi.org/10.1016/j.taap.2021.115649
Toxicology and Applied Pharmacology; Laurentino AOM, Solómon J et. al.

Jul 18th, 2021 - The use of the anthelmintic levamisole as a cocaine adulterant has been increasing worldwide. Complications caused by this association include systemic vasculitis, agranulocytosis, neutropenia, tissue necrosis, pulmonary hemorrhage, and renal injury. Data about toxicity of levamisole are scarce, therefore the aim of this study was to evaluate the acute and subchronic toxic effects of levamisole...