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About 14,575 results

TRPA1 as a potential factor and drug target in scleroderma: dermal fibrosis and alterna...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875496
Arthritis Research & Therapy; Mäki-Opas I, Hämäläinen M et. al.

Jan 27th, 2023 - Systemic sclerosis is a rheumatoid disease best known for its fibrotic skin manifestations called scleroderma. Alternatively activated (M2-type) macrophages are normally involved in the resolution of inflammation and wound healing but also in fibrosing diseases such as scleroderma. TRPA1 is a non-selective cation channel, activation of which causes pain and neurogenic inflammation. In the prese...

Editorial: Silicosis, asbestos-related diseases, war-site exposures and a variety of to...
https://doi.org/10.1097/MCP.0000000000000936
Current Opinion in Pulmonary Medicine; Joshi M, Varkey B

Jan 26th, 2023 - Editorial: Silicosis, asbestos-related diseases, war-site exposures and a variety of topics in chronic obstructive pulmonary disease.|2023|Joshi M,Varkey B,|etiology,toxicity,etiology,

Silica-associated lung disease in developing countries.
https://doi.org/10.1097/MCP.0000000000000940
Current Opinion in Pulmonary Medicine; Dhooria S, Sehgal IS et. al.

Jan 26th, 2023 - There is a considerable burden of silica-associated lung diseases in the developing world. This review summarizes the epidemiology of these diseases, especially silicosis and silico-tuberculosis, mitigative efforts and treatment, especially in the context of developing countries. In 2017, the highest incidence of silicosis was in China, India and Brazil among the developing countries. The preva...

A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873647
Nature Communications; Gao Y, Guitton-Sert L et. al.

Jan 25th, 2023 - Fanconi Anemia (FA) is a rare, genome instability-associated disease characterized by a deficiency in repairing DNA crosslinks, which are known to perturb several cellular processes, including DNA transcription, replication, and repair. Formaldehyde, a by-product of metabolism, is thought to drive FA by generating DNA interstrand crosslinks (ICLs) and DNA-protein crosslinks (DPCs). However, the...

The Italian Experience in the Development of Mesothelioma Registries: A Pathway for Oth...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858856
International Journal of Environmental Research and Publi... Magnani C, Mensi C et. al.

Jan 22nd, 2023 - Asbestos (all forms, including chrysotile, crocidolite, amosite, tremolite, actinolite, and anthophyllite) is carcinogenic to humans and causally associated with mesothelioma and cancer of the lung, larynx, and ovary. It is one of the carcinogens most diffuse in the world, in workplaces, but also in the environment and is responsible for a very high global cancer burden. A large number of count...

Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injecti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843913
BMC Cancer; Giri SR, Bhoi B et. al.

Jan 18th, 2023 - Saroglitazar is a novel PPAR-α/γ agonist with predominant PPAR-α activity. In various preclinical models, saroglitazar has been shown to prevent & reverse symptoms of NASH. In view of these observations, and the fact that NASH is a progressive disease leading to HCC, we hypothesized that saroglitazar may prevent the development of HCC in rodents. HCC was induced in C57BL/6 mice by a single intr...

Asbestos-associated pulmonary disease.
https://doi.org/10.1097/MCP.0000000000000939
Current Opinion in Pulmonary Medicine; Caceres JD, Venkata AN

Jan 12th, 2023 - Exposure to asbestos can cause both benign and malignant, pulmonary and pleural diseases. In the current era of low asbestos exposure, it is critical to be aware of complications from asbestos exposure; as they often arise after decades of exposure, asbestos-related pulmonary complications include asbestosis, pleural plaques, diffuse pleural thickening, benign asbestos-related pleural effusions...

Molecular imaging of chemokine-like receptor 1 (CMKLR1) in experimental acute lung injury.
https://doi.org/10.1073/pnas.2216458120
Proceedings of the National Academy of Sciences of the Un... Mannes PZ, Barnes CE et. al.

Jan 11th, 2023 - The lack of techniques for noninvasive imaging of inflammation has challenged precision medicine management of acute respiratory distress syndrome (ARDS). Here, we determined the potential of positron emission tomography (PET) of chemokine-like receptor-1 (CMKLR1) to monitor lung inflammation in a murine model of lipopolysaccharide-induced injury. Lung uptake of a CMKLR1-targeting radiotracer, ...

The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to de...
https://doi.org/10.1016/j.ecoenv.2023.114511
Ecotoxicology and Environmental Safety; Zhang J, Tang Y et. al.

Jan 7th, 2023 - Fluoride is capable of inducing developmental neurotoxicity; regrettably, the mechanism is obscure. We aimed to probe the role of lysosomal biogenesis disorder in developmental fluoride neurotoxicity-specifically, the regulating effect of the transient receptor potential mucolipin 1 (TRPML1)/transcription factor EB (TFEB) signaling pathway on lysosomal biogenesis. Sprague-Dawley rats were given...

Ardisia gigantifolia stapf (Primulaceae): A review of ethnobotany, phytochemistry, phar...
https://doi.org/10.1016/j.jep.2022.116079
Journal of Ethnopharmacology; Tian-Liang , Xi-Gu-Ri-Gan et. al.

Jan 6th, 2023 - Ardisia gigantifolia Stapf, known as Zou-ma-tai (in Chinese), is a traditional folk medicine, which was commonly used by Dong, Jing, Li, Maonan, Miao, Mulam, Yao, and Zhuang people. The main use of A. gigantifolia is the treatment of rheumatoid arthritis, gouty arthritis, fractures, osteoproliferation, traumatic injuries, gynecological, and neurological diseases. Current studies have shown that...

Pyrethroid insecticides pose greater risk than organophosphate insecticides to biocontr...
https://doi.org/10.1016/j.envpol.2022.120952
Environmental Pollution (Barking, Essex : 1987); Haggerty CJE, Delius BK et. al.

Jan 1st, 2023 - Use of agrochemicals, including insecticides, is vital to food production and predicted to increase 2-5 fold by 2050. Previous studies have shown a positive association between agriculture and the human infectious disease schistosomiasis, which is problematic as this parasitic disease infects approximately 250 million people worldwide. Certain insecticides might runoff fields and be highly toxi...

Tanreqing injection protects against bleomycin-induced pulmonary fibrosis via inhibitin...
https://doi.org/10.1016/j.jep.2022.116071
Journal of Ethnopharmacology; Deng J, He Y et. al.

Dec 31st, 2022 - Idiopathic pulmonary fibrosis (IPF), characterized by excessive collagen deposition, is a progressive and typically fatal lung disease without effective therapeutic methods. Tanreqing injection (TRQ), a Traditional Chinese Patent Medicine, has been widely used to treat inflammatory respiratory diseases clinically. The present work aims to elucidate the therapeutic effects and the possible mecha...

Targeted delivery of ursolic acid and oleanolic acid to lungs in the form of an inhaler...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799288
PloS One; Saini V, Debnath SK et. al.

Dec 30th, 2022 - Ursolic acid (UA) and oleanolic acid (OA) are triterpenoids. They are used to treat numerous diseases, including tuberculosis. Combinations of these drugs provide new insight into the management of tuberculosis. The major obstacle is the effective delivery of these drugs to the lungs, which are mainly affected due to M. tuberculosis. A metered-dose inhaler (MDI) was developed to address this is...

Prognostic biomarker prediction for glioma induced by heavy metals and their mixtures: ...
https://doi.org/10.1016/j.taap.2022.116356
Toxicology and Applied Pharmacology; Nguyen HD

Dec 24th, 2022 - Although there is an association between heavy metals and glioma, the molecular mechanisms involved in glioma development remain unclear. Therefore, this study aimed to assess the molecular mechanisms implicated in glioma development induced by heavy metals and their mixtures using various methodologies and databases (CTD, Google Scholar, PubMed, ScienceDirect, SpringerLink, miRNAsong, GeneMANI...

Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum di...
https://doi.org/10.1016/j.neuro.2022.12.006
Neurotoxicology Viana CE, Bortolotto VC et. al.

Dec 18th, 2022 - Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction and repetitive behaviors. In this study, we assessed the effect of lutein-loaded nanoparticles on ASD-like behaviors induced by prenatal valproic acid (VPA) exposure in female offspring rats and the possible involvement of oxidative stress and apoptosis. Pregnant female Wistar rats re...

ATM deficiency aggravates the progression of liver fibrosis induced by carbon tetrachlo...
https://doi.org/10.1016/j.tox.2022.153397
Toxicology Li M, Yang Z et. al.

Dec 17th, 2022 - Ataxia telangiectasia mutated (ATM) is a pivotal sensor during the DNA damage response that slows cell passage through the cell cycle checkpoints to facilitate DNA repair, and liver fibrosis is an irreversible pathological consequence of the sustained wound-healing process, However, the effects of ATM on the development of liver fibrosis are still not fully understood. Therefore, the aim of the...

The cytological and electrophysiological effects of silver nanoparticles on neuron-like...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746933
PloS One; Zhang Z, Meng C et. al.

Dec 14th, 2022 - The aim of this study was to investigate the toxic effects and mechanism of silver nanoparticles (SNPs) on the cytological and electrophysiological properties of rat adrenal pheochromocytoma (PC12) cells. Different concentrations of SNPs (20 nm) were prepared, and the effects of different application durations on the cell viability and electrical excitability of PC12 quasi-neuronal networks wer...

Disease Latency according to Asbestos Exposure Characteristics among Malignant Mesothel...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738972
International Journal of Environmental Research and Publi... Huh DA, Chae WR et. al.

Dec 12th, 2022 - Korea was one of the major consumers of asbestos in the late 1900s, and asbestos-related disease patients have been reported continuously to date, owing to long disease latency. Several studies have been conducted to predict the future incidence of malignant mesothelioma and lung cancer in Korea, but little is understood about the latency time. Therefore, the aim of this study is to estimate th...

Asbestos Exposure and Severity of COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739528
International Journal of Environmental Research and Publi... Granados G, Sáez-López M et. al.

Dec 12th, 2022 - The aim of this study was to analyse the relationship between occupational exposure to asbestos and the severity of SARS-CoV-2 infection. We evaluated patients who survived admission in our centre for COVID-19 pneumonia. Demographic, analytical, and clinical variables were collected during admission. After discharge, a previously validated occupational exposure to asbestos questionnaire was adm...

Key role of the gut-microbiota-brain axis via the subdiaphragmatic vagus nerve in demye...
https://doi.org/10.1016/j.nbd.2022.105951
Neurobiology of Disease; Wang X, Eguchi A et. al.

Dec 10th, 2022 - Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that of patients with MS. Given the role of the vagus nerve in gut-microbiota-brain axis in development of MS, we performed this study to investigate whether subdiaphragmatic vagotomy (SDV) affects demyelination in CPZ-trea...