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About 13,493 results

eEF1A2 knockdown impairs neuronal proliferation and inhibits neurite outgrowth of diffe...
https://doi.org/10.1097/WNR.0000000000001791
Neuroreport Rumpansuwon K, Prommahom A et. al.

May 21st, 2022 - The translation elongation factor-1, alpha-2 (eEF1A2) plays an important role in protein synthesis. Mutations in this gene have been described in individuals with neurodevelopmental disorders. Here, we silenced the expression of eEFA2 in human SH-SY5Y neuroblastoma cells and observed its roles in neuronal proliferation and differentiation upon induction with retinoic acid. eEF1A2 were silenced ...

Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats b...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108400
International Journal of Medical Sciences; Yu M, Wu X et. al.

May 19th, 2022 - Pulmonary arterial hypertension (PAH) characterized by pulmonary vascular remodeling is a lethal disease. Paeoniflorin (PF) is a monoterpene glycoside with numerous beneficial functions, such as vasodilation, anti-inflammation and immunomodulation. This study aims to investigate the effects of PF on monocrotaline (MCT)-induced PAH rats. Our data showed that both prophylactic or therapeutic admi...

Frequency of Asbestos Exposure and Histological Subtype of Ovarian Carcinoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100164
International Journal of Environmental Research and Publi... Vidican P, Perol O et. al.

May 15th, 2022 - The International Agency for Research on Cancer established a causal link between asbestos exposure and ovarian cancer. However, the exposure frequency and histological characteristics of asbestos-associated ovarian cancers remain to be investigated in detail. This multicenter case-case study assessed the asbestos exposure in ovarian carcinoma (OC) patients, alongside its association with histo...

Lagged Effects of Exposure to Air Pollutants on the Risk of Pulmonary Tuberculosis in a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106023
International Journal of Environmental Research and Publi... Feng Y, Wei J et. al.

May 15th, 2022 - Although significant correlations have been observed between air pollutants and the development of pulmonary tuberculosis (PTB) in many developed countries, data are scarce for developing and highly polluted regions. A combined Poisson generalized linear regression-distributed lag nonlinear model was used to determine the associations between long-term exposure (2005-2017) to air pollutants and...

Curcumin alleviated lipopolysaccharide-evoked H9c2 cells damage via suppression of inte...
https://doi.org/10.1177/09603271211069043
Human & Experimental Toxicology; Liu Y, Li X et. al.

May 14th, 2022 - Curcumin has been reported to have many benefits, including anti-inflammatory, anti-cancer, and so on. In this research, we aimed to investigate the function of curcumin on lipopolysaccharide (LPS)-injured H9c2 cells. H9c2 cells stimulated by LPS mimic the in vitro model of myocarditis injury. Comparative Toxicogenomics Database (CTD) was applied to detect the genes associated with curcumin. GE...

Exposure of female NZBWF1 mice to imiquimod-induced lupus nephritis at an early age via...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113305
Clinical and Experimental Immunology; Hayakawa K, Fujishiro M et. al.

May 14th, 2022 - Systemic lupus erythematosus (SLE) is a chronic inflammatory and representative autoimmune disease. Extremely complicated and multifactorial interactions between various genetic factors and individual susceptibility to environmental factors are involved in the pathogenesis of SLE. Several studies have reported that mutation and activation of toll-like receptor (TLR) 7 are involved in the onset ...

Tanshinone IIA alleviate rifampicin-induced cholestasis by regulating the expression an...
https://doi.org/10.1177/09603271221097365
Human & Experimental Toxicology; Liu L, Yang Y et. al.

May 12th, 2022 - Objective: Rifampicin (RFP) induces cholestasis due to long-term tubercular therapy. Impairment of the canalicular bile acids efflux via the bile salt export pump (BSEP) is a well-recognized cause of cholestasis. Tanshinone IIA (TAN IIA) has a protective effect on the liver. However, there are limited studies on the effects of RFP and TAN IIA on BSEP. In present study, we aimed to elucidate the...

Neuroprotective effect of Ginsenoside Re against neurotoxin‑induced Parkinson's disease...
https://doi.org/10.3892/mmr.2022.12731
Molecular Medicine Reports; Qiao J, Zhao Y et. al.

May 12th, 2022 - The aim of the present study was to examine the neuroprotective effects of a panel of active components of ginseng and to explore their molecular mechanisms of action in two rotenone (Rot)‑induced models of Parkinson's disease: An in vitro model using the human neuroblastoma cell line SH‑SY5Y and an in vivo model using Drosophila. Ginsenoside Re (Re) was identified as the most potent inhibitor ...

Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of th...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077942
Molecular Neurodegeneration; Zirngibl M, Assinck P et. al.

May 8th, 2022 - The dietary consumption of cuprizone - a copper chelator - has long been known to induce demyelination of specific brain structures and is widely used as model of multiple sclerosis. Despite the extensive use of cuprizone, the mechanism by which it induces demyelination are still unknown. With this review we provide an updated understanding of this model, by showcasing two distinct yet overlapp...

Periodontal disease affects oral cancer progression in a surrogate animal model for tob...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097773
International Journal of Oncology; Spuldaro TR, Wagner VP et. al.

May 7th, 2022 - For decades, the link between poor oral hygiene and the increased prevalence of oral cancer has been suggested. Most recently, emerging evidence has suggested that chronic inflammatory diseases from the oral cavity (e.g., periodontal disease), to some extent, play a role in the development of oral squamous cell carcinoma (OSCC). The present study aimed to explore the direct impact of biofilm‑in...

Progressive pulmonary fibrosis in a murine model of Hermansky-Pudlak syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066931
Respiratory Research; Abudi-Sinreich S, Bodine SP et. al.

May 6th, 2022 - HPS-1 is a genetic type of Hermansky-Pudlak syndrome (HPS) with highly penetrant pulmonary fibrosis (HPSPF), a restrictive lung disease that is similar to idiopathic pulmonary fibrosis (IPF). Hps1ep/ep (pale ear) is a naturally occurring HPS-1 mouse model that exhibits high sensitivity to bleomycin-induced pulmonary fibrosis (PF). Traditional methods of administering bleomycin as an intratrache...

Disturbance of serum lipid metabolites and potential biomarkers in the Bleomycin model ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066762
BMC Pulmonary Medicine; Yang XH, Wang FF et. al.

May 6th, 2022 - Altered metabolic pathways have recently been considered as potential drivers of idiopathic pulmonary fibrosis (IPF) for the study of drug therapeutic targets. However, our understanding of the metabolite profile during IPF formation is lacking. To comprehensively characterize the metabolic disorders of IPF, a mouse IPF model was constructed by intratracheal injection of bleomycin into C57BL/6J...

Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes...
https://doi.org/10.1158/1940-6207.CAPR-21-0529
Cancer Prevention Research (Philadelphia, Pa.); Vageli DP, Doukas PG et. al.

May 4th, 2022 - Tobacco smoking is the most known risk factor for hypopharyngeal cancer. Bile reflux has recently been documented as an independent risk factor for NFκB-mediated hypopharyngeal squamous cell carcinoma. However, the carcinogenic effect of tobacco smoke on the hypopharynx and its combination with bile has not yet been proven by direct evidence. We investigated whether in vivo chronic exposure (12...

Differential metabolome responses to deltamethrin between resistant and susceptible Ano...
https://doi.org/10.1016/j.ecoenv.2022.113553
Ecotoxicology and Environmental Safety; Li Y, Li Y et. al.

Apr 29th, 2022 - Insecticide-based vector control measures play an important role in the prevention and control of insect-borne infectious diseases such as malaria; however, insecticide resistance has become a severe global problem for vector control. To date, the metabolic mechanism by which Anopheles sinensis, the most widely distributed malaria vector in China and Asia, detoxifies insecticides is not clear. ...

Thallium Induces Antiproliferative and Cytotoxic Activity in Glioblastoma C6 and U373 C...
https://doi.org/10.1007/s12640-022-00514-6 10.1038/s41598-021-95278-y 10.1097/MCO.0b013e32833a5577 10.1016/S0378-4274(02)00427-7 10.1007/s11060-009-9875-7 10.1146/annurev.immunol.16.1.395 10.1196/annals.1338.064 10.1038/s41598-019-43413-1 10.1002/mgg3.116 10.1002/jmri.22263 10.1002/tox.21900 10.1002/jat.2550050106 10.1016/j.fct.2005.02.006 10.1016/S0378-4274(98)00126-X 10.1016/j.cell.2011.02.013 10.1016/j.taap.2006.07.003 10.1016/j.taap.2008.12.029 10.1016/j.redox.2020.101576 10.1111/j.1750-3639.1999.tb00536.x 10.1007/s10863-009-9225-7 10.1007/s12640-017-9863-1 10.1016/S0006-291X(76)80273-2 10.1007/978-3-319-60189-2_17 10.1177/1091581815603936 10.1021/bi981898w 10.1111/j.1699-0463.1968.tb03502.x 10.1002/tox.20590 10.1038/nprot.2008.75 10.1016/0887-2333(94)90028-0 10.1007/BF00334631 10.1002/tox.21934 10.4161/cbt.12.11.18140 10.1016/j.toxlet.2013.11.018 10.1159/000028073 10.1124/pr.117.014944 10.1021/bi8017174 10.1016/j.tox.2006.01.028 10.1080/10715760400000950 10.1111/j.1471-4159.2007.04634.x 10.1038/s41598-016-0028-x
Neurotoxicity Research; Rangel-López E, Robles-Bañuelos B et. al.

Apr 28th, 2022 - Thallium (Tl+) is a heavy metal that causes toxicity in several organs, including the brain. Its cytotoxic profile, combined with its affinity for tumor cells when used as a radioligand for labeling these cells, suggests its potential use as antitumor therapy. In this study, glioblastoma cell lines C6 (from rat) and U373 (from human) were exposed to increased concentrations of thallium(I) aceta...

4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells b...
https://doi.org/10.1016/j.neuro.2022.04.008
Neurotoxicology Lv J, Cheng H et. al.

Apr 27th, 2022 - Prolonged sevoflurane exposure leads to neurotoxicity. Autophagy plays an important role in promoting cell survival in different conditions. However, the role and mechanism of autophagy in sevoflurane-induced neurotoxicity were not fully elucidated. We attempted to indicate whether sevoflurane could activate the AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR)-mediated...

PEDF is an antifibrosis factor that inhibits the activation of fibroblasts in a bleomyc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027047
Respiratory Research; Qin X, Jia C et. al.

Apr 24th, 2022 - Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous and fatal lung disease. In addition to dense fibrous tissue, abnormal angiogenesis is also an important feature of IPF. Pigment epithelium-derived factor (PEDF) is an angiogenesis inhibitor and a potential anti-fibrous factor. The purpose of this experiment is to observe the effect of PEDF on bleomycin (BLM)-induced pulmonary fibrosi...

Polychlorinated Biphenyls and Pulmonary Hypertension.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029704
International Journal of Environmental Research and Publi... Assaggaf H, Yoo C et. al.

Apr 24th, 2022 - Polychlorinated biphenyls (PCBs) are persistent environmental pollutants that were banned because of their potential carcinogenicity. Population studies have shown that PCBs are associated with lung toxicity and hypertension. The objective of this study was to evaluate whether higher exposure to PCB congeners is associated with the risk of pulmonary hypertension. Serum levels of PCBs in 284 sub...

Disruption of mitochondrial redox homeostasis as a mechanism of antimony-induced reacti...
https://doi.org/10.1016/j.ecoenv.2022.113519
Ecotoxicology and Environmental Safety; Su L, Fang W et. al.

Apr 23rd, 2022 - Occupational and environmental Sb exposure has been associated with increased risk of respiratory diseases and lung cancer, but the toxicities and molecular mechanisms of Sb have been less investigated. In the present study, we first analyzed the Sb toxicity profile of lung adenocarcinoma A549 cells, and found that Sb dose-dependently decreased the cell viability and arrested cell cycle at G2/M...

Paraquat-induced oxidative stress regulates N6-methyladenosine (m6A) modification of lo...
https://doi.org/10.1016/j.ecoenv.2022.113503
Ecotoxicology and Environmental Safety; Su Q, Chen N et. al.

Apr 23rd, 2022 - Paraquat (PQ) is a ubiquitously applied herbicide. Long-term PQ exposure with low dose has been reported to induce abnormal expression of long non-coding RNAs (lncRNAs) in brain nerve cells, which could further lead to Parkinson's disease (PD). N6-methyladenosine (m6A) modification has recently been identified as having an important role in regulating the function of lncRNAs. However, how m6A m...