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About 13,875 results

Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyropt...
https://doi.org/10.1186/s12974-022-02598-5
Journal of Neuroinflammation; Jing G, Zuo J et. al.

Sep 29th, 2022 - Microglia pyroptosis-mediated neuroinflammation is thought to be the crucial pathogenesis of sepsis-associated encephalopathy (SAE). Erbin has been reported to be associated with various inflammatory diseases. However, the role of Erbin in SAE and the relationship between Erbin and microglia pyroptosis are unknown. In this study, we investigated the promising role and underlying molecular mecha...

Impacts of Pesticides on Oral Cavity Health and Ecosystems: A Review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517265
International Journal of Environmental Research and Publi... Salazar-Flores J, Lomelí-Martínez SM et. al.

Sep 24th, 2022 - Pesticides are chemical substances used to control, prevent, or destroy agricultural, domestic, and livestock pests. These compounds produce adverse changes in health, and they have been associated with the development of multiple chronic diseases. This study aimed to present a detailed review of the effect of pesticides on the oral cavity and the oral microbiome. In the oral cavity, pesticides...

Pathological Comparison of Rat Pulmonary Models Induced by Silica Nanoparticles and Ind...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484578
International Journal of Nanomedicine; Guan Y, Liu N et. al.

Sep 23rd, 2022 - The objective of this study was to evaluate and compare the histopathological implications of silica nanoparticles (Nano-SiO2) and indium-tin oxide nanoparticles (Nano-ITO), in vivo. Male Sprague-Dawley rats were exposed to Nano-SiO2 (50 mg/kg) and Nano-ITO (6 mg/kg) by a single intratracheal instillation, respectively. Broncho-alveolar lavage fluid (BALF) and lung tissue were obtained at 7, 14...

Effects of tocilizumab and dexamethasone on the downregulation of proinflammatory cytok...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482261
Respiratory Research; Terzi F, Demirci B et. al.

Sep 18th, 2022 - Acute respiratory distress syndrome (ARDS) is a life-threatening disease caused by the induction of inflammatory cytokines and chemokines in the lungs. There is a dearth of drug applications that can be used to prevent cytokine storms in ARDS treatment. This study was designed to investigate the effects of tocilizumab and dexamethasone on oxidative stress, antioxidant parameters, and cytokine s...

Captopril alleviates epilepsy and cognitive impairment by attenuation of C3-mediated in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476304
Journal of Neuroinflammation; Dong X, Fan J et. al.

Sep 15th, 2022 - Evidence from experimental and clinical studies implicates immuno-inflammatory responses as playing an important role in epilepsy-induced brain injury. Captopril, an angiotensin-converting enzyme inhibitor (ACEi), has previously been shown to suppress immuno-inflammatory responses in a variety of neurological diseases. However, the therapeutic potential of captopril on epilepsy remains unclear....

Effect of heated tobacco products and traditional cigarettes on pulmonary toxicity and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461237
Toxicology Tsou HH, Wang PH et. al.

Sep 13th, 2022 - Cigarette smoke (CS) significantly contributes to the development of chronic obstructive pulmonary disease (COPD). Heated tobacco products (HTPs), newly developed cigarette products, have been proposed as an alternative for safe cigarette smoking. Although it is plausible to think that replacing traditional cigarettes with HTPs would lower the risks of COPD, this notion requires confirmation by...

Arsenite toxicity is regulated by queuine availability and oxidation-induced reprogramm...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499598
Proceedings of the National Academy of Sciences of the Un... Huber SM, Begley U et. al.

Sep 13th, 2022 - Cells respond to environmental stress by regulating gene expression at the level of both transcription and translation. The ∼50 modified ribonucleotides of the human epitranscriptome contribute to the latter, with mounting evidence that dynamic regulation of transfer RNA (tRNA) wobble modifications leads to selective translation of stress response proteins from codon-biased genes. Here we show ...

Macrophage derived miR-7219-3p-containing exosomes mediate fibroblast trans-differentia...
https://doi.org/10.1016/j.tox.2022.153310
Toxicology Niu Z, Wang L et. al.

Sep 9th, 2022 - Silicosis is one of the most serious occupational diseases with the main feature of inflammatory cell infiltration, fibroblasts activation, and large deposition of extracellular matrix in the lung. Increasing evidence indicates that macrophage-derived exosomes may play an important role in the development of silicosis by transferring their loaded microRNAs (miRNAs). Hence we carried out high-th...

Testing oxygenated microbubbles via intraperitoneal and intrathoracic routes on a large...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446406
Physiological Reports; Mohammed RUR, Zollinger NT et. al.

Sep 7th, 2022 - With a mortality rate of 46% before the onset of COVID-19, acute respiratory distress syndrome (ARDS) affected 200,000 people in the US, causing 75,000 deaths. Mortality rates in COVID-19 ARDS patients are currently at 39%. Extrapulmonary support for ARDS aims to supplement mechanical ventilation by providing life-sustaining oxygen to the patient. A new rapid-onset, human-sized pig ARDS model i...

Activation of PI3k/Akt/mTOR Signaling Induces Deposition of p-tau to Promote Aluminum N...
https://doi.org/10.1007/s12640-022-00573-9
Neurotoxicity Research; Xu Y, Zhang G et. al.

Sep 7th, 2022 - Aluminum neurotoxicity impairs learning and memory ability, but the molecular mechanism has not been elucidated. The aim of this study was to examine the role of phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling in regulating the expression of synaptic plasticity-related proteins (PRPs) and p-tau deposition to explore the mechanism underlying aluminum-induc...

Sanhuang xiexin decoction ameliorates secondary liver injury in DSS-induced colitis inv...
https://doi.org/10.1016/j.jep.2022.115682
Journal of Ethnopharmacology; Li L, Wang Y et. al.

Sep 5th, 2022 - SanHuang XieXin decoction (SXD) is a widely applicated traditional Chinese medicine (TCM) with a significant gut-liver axis regulation effect. To evaluate the therapeutic effect and elucidate the possible underlying molecular mechanisms of SXD on liver damage secondary to ulcerative colitis (UC) in mice. A model of liver damage secondary to UC was induced by drinking 5% dextran sodium sulfate (...

Glial Response to Intranasal Mesenchymal Stem Cells in Intermittent Cuprizone Model of ...
https://doi.org/10.1007/s12640-022-00556-w
Neurotoxicity Research; Zarini D, Pasbakhsh P et. al.

Sep 3rd, 2022 - Intranasal mesenchymal stem cells (MSCs) delivery is a non-invasive method that has received interests for treatment of neurodegenerative diseases, such as multiple sclerosis (MS). The impact of intranasal MSCs on intermittent cuprizone model of demyelination was a focus of this study. C57/BL6 mice were fed with 0.3% cuprizone in an intermittent or single ways. Luxol fast blue (LFB), Rotarod te...

Silver Nanoparticles Induce a Size-dependent Neurotoxicity to SH-SY5Y Neuroblastoma Cel...
https://doi.org/10.1007/s12640-022-00570-y
Neurotoxicity Research; Zhai X, Shan S et. al.

Aug 31st, 2022 - Silver nanoparticles (AgNPs) are widely used in a variety of consumer products because of their antibacterial and antifungal characteristics, but little is known about their toxicity to the brain. In this study, we investigated AgNP-induced neurotoxicity using the human neuroblastoma cancer (SH-SY5Y) cell line. After a 24 h treatment of AgNPs with two primary sizes (5 and 50 nm labeled as Ag-5 ...

Effects of Tartrazine on Some Sexual Maturation Parameters in Immature Female Wistar Rats.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408620
International Journal of Environmental Research and Publi... Mindang ELN, Awounfack CF et. al.

Aug 27th, 2022 - Over the past century, the average age for onset of puberty has declined. Several additives present in our food are thought to contribute significantly to this early puberty which is recognized to also affect people's health in later life. On this basis, the impact of 40-days unique oral administration of the food dye tartrazine (7.5, 27, and 47 mg/kg BW doses) was evaluated on some sexual matu...

Occupational Exposures and Esophageal Cancer: Prog Study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408612
International Journal of Environmental Research and Publi... Gressier A, Gourier G et. al.

Aug 27th, 2022 - Esophageal cancer is the sixth most common cause of cancer death worldwide. In France, Brittany is one of the regions most seriously affected. This increased incidence is usually linked to high rates of alcohol overconsumption and smoking, established risk factors for esophageal cancer, but the region has special occupational exposures. We aim to describe the occupational exposures of patients ...

Suppressive Effect of Fruiting Bodies of Medicinal Mushrooms on Demyelination and Motor...
https://doi.org/10.1615/IntJMedMushrooms.2022044840
International Journal of Medicinal Mushrooms; Yamashina K, Yamamoto S et. al.

Aug 26th, 2022 - Epidemiologic studies have shown a high prevalence of multiple sclerosis (MS) in Europe and North America, and a low prevalence in East Asia. Mushrooms contain various biological response modifiers (BRMs) and are widely used in traditional Chinese medicine in East Asian countries. To investigate whether mushrooms have potential beneficial effects on MS, we administered mushrooms to cuprizone (b...

The Effect of Tobacco Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406897
Current Oncology (Toronto, Ont.); Doukas SG, Vageli DP et. al.

Aug 26th, 2022 - Deregulation of the DNA mismatch repair (MMR) mechanism has been linked to poor prognosis of upper aerodigestive tract cancers. Our recent in vitro data have provided evidence of crosstalk between deregulated miRNAs and MMR genes, caused by tobacco smoke (TS) N-Nitrosamines, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), in hypopharyngeal cells. Here, we explored whether chronic exposure...

Shufeng Jiedu capsule inhibits inflammation and apoptosis by activating A2AAR and inhib...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392900
Journal of Ethnopharmacology; Cai J, Wang YL et. al.

Aug 25th, 2022 - Shufeng Jiedu capsule (SFJDC) is a pure form of traditional Chinese medicine (TCM) that contains eight medicinal plants. Known for its anti-inflammatory and antipyretic effects, it is mostly used to treat upper respiratory tract infections and other infectious diseases, such as colds, pharyngitis, laryngitis, and tonsillitis. Both acute lung injury (ALI) and COVID-19 are closely related to lung...

Determining drug dose in the era of targeted therapies: playing it (un)safe?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399108
Blood Cancer Journal; Skånland SS, Tjønnfjord GE

Aug 24th, 2022 - Targeted therapies against phosphatidylinositol 3-kinase (PI3K), Bruton's tyrosine kinase (BTK), and B-cell lymphoma-2 (BCL-2) are approved for chronic lymphocytic leukemia (CLL). Since approval of the first-in-class drugs, next-generation agents have become available and are continuously under development. While these therapies act on well-characterized molecular targets, this knowledge is onl...

Artichoke phytocomplex modulates serum microRNAs in patients exposed to asbestos: a fir...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391647
Journal of Experimental & Clinical Cancer Research : CR; Muti P, Sacconi A et. al.

Aug 21st, 2022 - Malignant pleural mesothelioma is a highly aggressive tumor associated with asbestos exposure. There are few effective treatment options for mesothelioma, and patients have a very poor prognosis. Mesothelioma has the potential to represent an appropriate disease to prevent because of its strong association with asbestos exposure and the long latency from exposure to the disease on-set. In the p...