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About 18,780 results

Reply to Wagman et al.: Data-driven assessments should establish the landscape of what ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499576
Proceedings of the National Academy of Sciences of the Un... Costantini C, Chandre F et. al.

Sep 13th, 2022 - Reply to Wagman et al.: Data-driven assessments should establish the landscape of what is "within reach" of malaria transmission control.|2022|Costantini C,Chandre F,Corbel V,Moiroux N,Simard F,|prevention & control,transmission,

A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedd...
https://doi.org/10.1073/pnas.2204624119
Proceedings of the National Academy of Sciences of the Un... Chaturvedi S, Beutler N et. al.

Sep 9th, 2022 - The high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a primary driver of the COVID-19 pandemic. While existing interventions prevent severe disease, they exhibit mixed efficacy in preventing transmission, presumably due to their limited antiviral effects in the respiratory mucosa, whereas interventions targeting the sites of viral replication might more e...

Wildlife susceptibility to infectious diseases at global scales.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436312
Proceedings of the National Academy of Sciences of the Un... Robles-Fernández ÁL, Santiago-Alarcon D et. al.

Aug 23rd, 2022 - Disease transmission prediction across wildlife is crucial for risk assessment of emerging infectious diseases. Susceptibility of host species to pathogens is influenced by the geographic, environmental, and phylogenetic context of the specific system under study. We used machine learning to analyze how such variables influence pathogen incidence for multihost pathogen assemblages, including on...

Human behaviour, NPI and mobility reduction effects on COVID-19 transmission in differe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394048
BMC Public Health; Mohammadi Z, Cojocaru MG et. al.

Aug 23rd, 2022 - The outbreak of Coronavirus disease, which originated in Wuhan, China in 2019, has affected the lives of billions of people globally. Throughout 2020, the reproduction number of COVID-19 was widely used by decision-makers to explain their strategies to control the pandemic. In this work, we deduce and analyze both initial and effective reproduction numbers for 12 diverse world regions between F...

Epidemiological, virological and serological investigation of a SARS-CoV-2 outbreak (Al...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385020
PloS One; Lorthe E, Bellon M et. al.

Aug 18th, 2022 - To report a prospective epidemiological, virological and serological investigation of a SARS-CoV-2 outbreak in a primary school. As part of a longitudinal, prospective, school-based surveillance study, this investigation involved repeated testing of 73 pupils, 9 teachers, 13 non-teaching staff and 26 household members of participants who tested positive, with rapid antigen tests and/or RT-PCR (...

Identification of basal complex protein that is essential for maturation of transmissio...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407223
Proceedings of the National Academy of Sciences of the Un... Clements RL, Morano AA et. al.

Aug 17th, 2022 - Malaria remains a global driver of morbidity and mortality. To generate new antimalarials, one must elucidate the fundamental cell biology of Plasmodium falciparum, the parasite responsible for the deadliest cases of malaria. A membranous and proteinaceous scaffold called the inner membrane complex (IMC) supports the parasite during morphological changes, including segmentation of daughter cell...

The effectiveness of COVID-19 testing and contact tracing in a US city.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407477
Proceedings of the National Academy of Sciences of the Un... Wang X, Du Z et. al.

Aug 16th, 2022 - Although testing, contact tracing, and case isolation programs can mitigate COVID-19 transmission and allow the relaxation of social distancing measures, few countries worldwide have succeeded in scaling such efforts to levels that suppress spread. The efficacy of test-trace-isolate likely depends on the speed and extent of follow-up and the prevalence of SARS-CoV-2 in the community. Here, we u...

Animal Reservoirs-Where the Next SARS-CoV-2 Variant Could Arise.
https://doi.org/10.1001/jama.2022.9789
JAMA Madhusoodanan J

Aug 4th, 2022 - Animal Reservoirs-Where the Next SARS-CoV-2 Variant Could Arise.|2022|Madhusoodanan J,|genetics,transmission,virology,virology,virology,genetics,

Risk of severe COVID-19 infection among adults with prior exposure to children.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388132
Proceedings of the National Academy of Sciences of the Un... Solomon MD, Escobar GJ et. al.

Jul 28th, 2022 - Susceptibility and severity of COVID-19 infection vary widely. Prior exposure to endemic coronaviruses, common in young children, may protect against SARS-CoV-2. We evaluated risk of severe COVID-19 among adults with and without exposure to young children in a large, integrated healthcare system. Adults with children 0-5 years were matched 1:1 to adults with children 6-11 years, 12-18 years, an...

Interferon resistance of emerging SARS-CoV-2 variants.
https://doi.org/10.1073/pnas.2203760119
Proceedings of the National Academy of Sciences of the Un... Guo K, Barrett BS et. al.

Jul 23rd, 2022 - The emergence of SARS-CoV-2 variants with enhanced transmissibility, pathogenesis, and resistance to vaccines presents urgent challenges for curbing the COVID-19 pandemic. While Spike mutations that enhance virus infectivity or neutralizing antibody evasion may drive the emergence of these novel variants, studies documenting a critical role for interferon responses in the early control of SARS-...

Abrupt decreases in infectivity of SARS-CoV-2 in aerosols.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304013
Proceedings of the National Academy of Sciences of the Un... Löndahl J, Alsved M

Jul 21st, 2022 - Abrupt decreases in infectivity of SARS-CoV-2 in aerosols.|2022|Löndahl J,Alsved M,|transmission,virology,growth & development,isolation & purification,pathogenicity,

COVID-19 Pandemic Planning Scenarios | CDC
https://www.cdc.gov/coronavirus/2019-ncov/hcp/planning-scenarios.html

Jul 14th, 2022 - Summary of Recent Changes. Updates as of March 19, 2021: The Infection Fatality Ratio (IFR) parameter has been updated to reflect recently published estimates. This parameter is now presented as the number of deaths per 1,000,000 infections for ease of interpretation. The healthcare utilization statistics in Table 2 have been updated to include a 0–17-years-old age group. This will be the final...

Strategies to Mitigate Healthcare Personnel Staffing Shortages | CDC
https://www.cdc.gov/coronavirus/2019-ncov/hcp/mitigating-staff-shortages.html

Jul 14th, 2022 - CDC guidance for SARS-CoV-2 infection may be adapted by state and local health departments to respond to rapidly changing local circumstances. This guidance provides information on strategies to mitigate healthcare personnel staffing shortages during the COVID-19 pandemic.   See history of updates. Summary of Recent Changes. Updates as of January 21, 2022. Due to concerns about increased transm...

Clinical Questions about COVID-19: Questions and Answers | CDC
https://www.cdc.gov/coronavirus/2019-ncov/hcp/faq.html

Jul 14th, 2022 - COVID-19 Risk. Who is at risk for infection with SARS-CoV-2, the virus that causes COVID-19? Currently, those at greatest risk of infection are persons who have had prolonged, unprotected close contact (i.e., within 6 feet for 15 minutes or longer) with a patient with confirmed SARS-CoV-2 infection, regardless of whether the patient has symptoms. Persons frequently in congregate settings (e.g.,...

Standard Operating Procedure (SOP) for Triage of Suspected COVID-19 Patients in non-US Healthcare Settings: Early Identification and Prevention of Transmission during Triage | CDC
https://www.cdc.gov/coronavirus/2019-ncov/hcp/non-us-settings/sop-triage-prevent-transmission.html

Jul 14th, 2022 - Summary of Recent Changes. Updates as of July 14, 2021 Minor revisions to improve clarity and flow of guidance. Key Points: Early identification and separation of suspected COVID-19 patients at triage is important to prevent transmission in healthcare facilities. Healthcare facility administrators need to provide public and patients with information on COVID-19 prevention measures before and up...

Interim Guidance for Managing Healthcare Personnel with SARS-CoV-2 Infection or Exposure to SARS-CoV-2 | CDC
https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-risk-assesment-hcp.html

Jul 14th, 2022 - Summary of Recent Changes. Updates as of January 21, 2022 Due to concerns about increased transmissibility of the SARS-CoV-2 Omicron variant, this guidance is being updated to enhance protection for healthcare personnel (HCP), patients, and visitors, and to address concerns about potential impacts on the healthcare system given a surge of SARS-CoV-2 infections. These updates will be refined as ...

Print Resources | CDC
https://www.cdc.gov/coronavirus/2019-ncov/communication/print-resources.html

Jul 14th, 2022 - COVID Corrections Guidance Webinar-5.19.22 Slide deck outlining the May 3, 2022 Corrections Guidance for COVID-19 for correctional and detention facility staff and administrators. COVID-19_How-to-Determine-Close-Contacts-HTML Don't Delay: Test Soon and Treat Early If you are having COVID-19 symptoms and at high risk of getting very sick, don’t delay. Test as soon as possible and if posi...

Comparative genomic analysis of the human genome and six bat genomes using unsupervised...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264310
BMC Genomics; Iwasaki Y, Ikemura T et. al.

Jul 9th, 2022 - Emerging infectious disease-causing RNA viruses, such as the SARS-CoV-2 and Ebola viruses, are thought to rely on bats as natural reservoir hosts. Since these zoonotic viruses pose a great threat to humans, it is important to characterize the bat genome from multiple perspectives. Unsupervised machine learning methods for extracting novel information from big sequence data without prior knowled...

Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433318
Nature Karthikeyan S, Levy JI et. al.

Jul 8th, 2022 - As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing is infeasible at scale, especially in areas with limited resources, participation, or testing and/or sequencing capacity, which can also introduce biases1-3. SARS-CoV-2 RNA concentration in wastewater successfully tracks re...

A male steroid controls female sexual behaviour in the malaria mosquito.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352575
Nature Peng D, Kakani EG et. al.

Jul 7th, 2022 - Insects, unlike vertebrates, are widely believed to lack male-biased sex steroid hormones1. In the malaria mosquito Anopheles gambiae, the ecdysteroid 20-hydroxyecdysone (20E) appears to have evolved to both control egg development when synthesized by females2 and to induce mating refractoriness when sexually transferred by males3. Because egg development and mating are essential reproductive t...