Journal of Virology; Choi SSA, Chan HH et. al.
Dec 1st, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the acute respiratory disease coronavirus disease 2019 (COVID-19), which has resulted in millions of deaths globally. Here, we explored the mechanism of host cell entry of a luciferase-ZsGreen spike (SARS-CoV-2)-pseudotyped lentivirus using zebrafish embryos/larvae as an in vivo model. Successful pseudovirus ...
Journal of Virology; Belser JA, Sun X et. al.
Dec 1st, 2022 - Despite reports of confirmed human infection following ocular exposure with both influenza A virus (IAV) and SARS-CoV-2, the dynamics of virus spread throughout oculonasal tissues and the relative capacity of virus transmission following ocular inoculation remain poorly understood. Furthermore, the impact of exposure route on subsequent release of airborne viral particles into the air has not b...
JAMA Kuehn BM
Oct 26th, 2022 - Clinicians at Low Risk of Acquiring Monkeypox From Patients.|2022|Kuehn BM,|epidemiology,transmission,statistics & numerical data,statistics & numerical data,
The Journal of Hospital Infection; O'Connell L, Asad H et. al.
Oct 15th, 2022 - Hospital transmission of SARS-CoV-2 has proved difficult to control, with healthcare-associated infections troublesome throughout. To understand factors contributing to hospital transmission of infections, which is necessary for containing spread. An outbreak of 56 staff and patient cases of COVID-19 over a 31-day period in a tertiary referral unit is presented, with at least a further 29 cases...
JAMA Kuehn BM
Sep 28th, 2022 - Long-term Household Contamination With Monkeypox Virus Investigated.|2022|Kuehn BM,|virology,transmission,isolation & purification,
Proceedings of the National Academy of Sciences of the Un... Costantini C, Chandre F et. al.
Sep 13th, 2022 - Reply to Wagman et al.: Data-driven assessments should establish the landscape of what is "within reach" of malaria transmission control.|2022|Costantini C,Chandre F,Corbel V,Moiroux N,Simard F,|prevention & control,transmission,
Proceedings of the National Academy of Sciences of the Un... Chaturvedi S, Beutler N et. al.
Sep 9th, 2022 - The high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a primary driver of the COVID-19 pandemic. While existing interventions prevent severe disease, they exhibit mixed efficacy in preventing transmission, presumably due to their limited antiviral effects in the respiratory mucosa, whereas interventions targeting the sites of viral replication might more e...
BMC Public Health; Mohammadi Z, Cojocaru MG et. al.
Aug 23rd, 2022 - The outbreak of Coronavirus disease, which originated in Wuhan, China in 2019, has affected the lives of billions of people globally. Throughout 2020, the reproduction number of COVID-19 was widely used by decision-makers to explain their strategies to control the pandemic. In this work, we deduce and analyze both initial and effective reproduction numbers for 12 diverse world regions between F...
Proceedings of the National Academy of Sciences of the Un... Robles-Fernández ÁL, Santiago-Alarcon D et. al.
Aug 23rd, 2022 - Disease transmission prediction across wildlife is crucial for risk assessment of emerging infectious diseases. Susceptibility of host species to pathogens is influenced by the geographic, environmental, and phylogenetic context of the specific system under study. We used machine learning to analyze how such variables influence pathogen incidence for multihost pathogen assemblages, including on...
PloS One; Lorthe E, Bellon M et. al.
Aug 18th, 2022 - To report a prospective epidemiological, virological and serological investigation of a SARS-CoV-2 outbreak in a primary school. As part of a longitudinal, prospective, school-based surveillance study, this investigation involved repeated testing of 73 pupils, 9 teachers, 13 non-teaching staff and 26 household members of participants who tested positive, with rapid antigen tests and/or RT-PCR (...
Proceedings of the National Academy of Sciences of the Un... Clements RL, Morano AA et. al.
Aug 17th, 2022 - Malaria remains a global driver of morbidity and mortality. To generate new antimalarials, one must elucidate the fundamental cell biology of Plasmodium falciparum, the parasite responsible for the deadliest cases of malaria. A membranous and proteinaceous scaffold called the inner membrane complex (IMC) supports the parasite during morphological changes, including segmentation of daughter cell...
Proceedings of the National Academy of Sciences of the Un... Wang X, Du Z et. al.
Aug 16th, 2022 - Although testing, contact tracing, and case isolation programs can mitigate COVID-19 transmission and allow the relaxation of social distancing measures, few countries worldwide have succeeded in scaling such efforts to levels that suppress spread. The efficacy of test-trace-isolate likely depends on the speed and extent of follow-up and the prevalence of SARS-CoV-2 in the community. Here, we u...
Nature Turakhia Y, Thornlow B et. al.
Aug 12th, 2022 - Accurate and timely detection of recombinant lineages is crucial for interpreting genetic variation, reconstructing epidemic spread, identifying selection and variants of interest, and accurately performing phylogenetic analyses1-4. During the SARS-CoV-2 pandemic, genomic data generation has exceeded the capacities of existing analysis platforms, thereby crippling real-time analysis of viral ev...
Nature McCrone JT, Hill V et. al.
Aug 12th, 2022 - The SARS-CoV-2 Delta (Pango lineage B.1.617.2) variant of concern spread globally, causing resurgences of COVID-19 worldwide1,2. The emergence of the Delta variant in the UK occurred on the background of a heterogeneous landscape of immunity and relaxation of non-pharmaceutical interventions. Here we analyse 52,992 SARS-CoV-2 genomes from England together with 93,649 genomes from the rest of th...
JAMA Madhusoodanan J
Aug 4th, 2022 - Animal Reservoirs-Where the Next SARS-CoV-2 Variant Could Arise.|2022|Madhusoodanan J,|genetics,transmission,virology,virology,virology,genetics,
Proceedings of the National Academy of Sciences of the Un... Solomon MD, Escobar GJ et. al.
Jul 28th, 2022 - Susceptibility and severity of COVID-19 infection vary widely. Prior exposure to endemic coronaviruses, common in young children, may protect against SARS-CoV-2. We evaluated risk of severe COVID-19 among adults with and without exposure to young children in a large, integrated healthcare system. Adults with children 0-5 years were matched 1:1 to adults with children 6-11 years, 12-18 years, an...
Proceedings of the National Academy of Sciences of the Un... Guo K, Barrett BS et. al.
Jul 23rd, 2022 - The emergence of SARS-CoV-2 variants with enhanced transmissibility, pathogenesis, and resistance to vaccines presents urgent challenges for curbing the COVID-19 pandemic. While Spike mutations that enhance virus infectivity or neutralizing antibody evasion may drive the emergence of these novel variants, studies documenting a critical role for interferon responses in the early control of SARS-...
Proceedings of the National Academy of Sciences of the Un... Löndahl J, Alsved M
Jul 21st, 2022 - Abrupt decreases in infectivity of SARS-CoV-2 in aerosols.|2022|Löndahl J,Alsved M,|transmission,virology,growth & development,isolation & purification,pathogenicity,
Jul 14th, 2022 - Summary of Recent Changes. Updates as of March 19, 2021: The Infection Fatality Ratio (IFR) parameter has been updated to reflect recently published estimates. This parameter is now presented as the number of deaths per 1,000,000 infections for ease of interpretation. The healthcare utilization statistics in Table 2 have been updated to include a 0–17-years-old age group. This will be the final...
Jul 14th, 2022 - Summary of Recent Changes. Updates as of January 21, 2022 Due to concerns about increased transmissibility of the SARS-CoV-2 Omicron variant, this guidance is being updated to enhance protection for healthcare personnel (HCP), patients, and visitors, and to address concerns about potential impacts on the healthcare system given a surge of SARS-CoV-2 infections. These updates will be refined as ...