×
About 5,080 results

Case report: a 5-year-old with new onset nephrotic syndrome in the setting of COVID-19 ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476119
BMC Nephrology; Morgan KM, Imani PD

Sep 29th, 2021 - This is a case report of an asymptomatic SARS-CoV-2 infection associated with new-onset nephrotic syndrome in a pediatric patient. This is the third case of new-onset nephrotic syndrome in children associated with SARS-CoV-2 infection, but is the first case report describing a new-onset nephrotic syndrome presentation in a patient who had asymptomatic COVID-19 infection. This is a case of a pre...

Extracellular vesicles and exosomes generated from cystic renal epithelial cells promot...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316472
Nature Communications; Ding H, Li LX et. al.

Jul 29th, 2021 - Autosomal dominant polycystic kidney disease (ADPKD) is caused by germline mutations of PKD1 or PKD2 on one allele and a somatic mutation inactivating the remaining normal allele. However, if and how null ADPKD gene renal epithelial cells affect the biology and function of neighboring cells, including heterozygous renal epithelial cells, fibroblasts and macrophages during cyst initiation and ex...

Accuracy of Two Circulating Antigen Tests for the Diagnosis and Surveillance of Schisto...
https://doi.org/10.4269/ajtmh.21-0031
The American Journal of Tropical Medicine and Hygiene; Assaré RK, Tra-Bi MI et. al.

Jul 20th, 2021 - In low-endemicity settings, current tools for the diagnosis and surveillance of schistosomiasis are often inaccurate in detecting true infection. We assessed the accuracy of an up-converting phosphor lateral flow circulating anodic antigen (UCP-LF CAA) test and a point-of-care circulating cathodic antigen (POC-CCA) urine cassette test for the diagnosis of Schistosoma mansoni. Our study was cond...

Ultrabright plasmonic fluor nanolabel-enabled detection of a urinary ER stress biomarke...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424663
American Journal of Physiology. Renal Physiology; Kim Y, Wang Z et. al.

Jul 13th, 2021 - Autosomal dominant tubulointerstitial kidney disease (ADTKD)-uromodulin (UMOD) is the most common nonpolycystic genetic kidney disease, but it remains unrecognized due to its clinical heterogeneity and lack of screening test. Moreover, the fact that the clinical feature is a poor predictor of disease outcome further highlights the need for the development of mechanistic biomarkers in ADTKD. How...

Persistence of SARS-CoV-2 RNA in the nasopharyngeal, blood, urine, and stool samples of...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248752
Virology Journal; Joukar F, Yaghubi Kalurazi T et. al.

Jul 3rd, 2021 - The persistence of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) RNA in the body fluids of patients with the novel coronavirus disease 2019 (COVID-19) may increase the potential risk of viral transmission. There is still uncertainty on whether the recommended quarantine duration is sufficient to reduce the risk of transmission. This study aimed to investigate the persistence of S...

Associations of IL13 gene polymorphisms and immune factors with Schistosoma haematobium...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274844
PLoS Neglected Tropical Diseases; Sarpong-Baidoo M, Ofori MF et. al.

Jun 30th, 2021 - Schistosomiasis remains a major public health issue with over 90% of the prevalence rates recorded in Sub-Saharan Africa. In this study, the relationships between different interleukin gene polymorphisms (IL-13-591A/G, IL-13-1055C/T, IL-13-1258A/G) and Schistosoma haematobium infection levels were evaluated; as well as the host plasma antibodies and cytokine profiles associated with schistosomi...

Urogenital schistosomiasis infection prevalence targets to determine elimination as a p...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221785
PLoS Neglected Tropical Diseases; Wiegand RE, Fleming FM et. al.

Jun 12th, 2021 - Recent research suggests that schistosomiasis targets for morbidity control and elimination as a public health problem could benefit from a reanalysis. These analyses would define evidence-based targets that control programs could use to confidently assert that they had controlled or eliminated schistosomiasis as a public health problem. We estimated how low Schistosoma haematobium infection le...

High SARS-CoV-2 Viral Load in Urine Sediment Correlates with Acute Kidney Injury and Po...
https://doi.org/10.1681/ASN.2021010059
Journal of the American Society of Nephrology : JASN; Caceres PS, Savickas G et. al.

Jun 6th, 2021 - AKI is a complication of coronavirus disease 2019 (COVID-19) that is associated with high mortality. Despite documented kidney tropism of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there are no consistent reports of viral detection in urine or correlation with AKI or COVID-19 severity. Here, we hypothesize that quantification of the viral load of SARS-CoV-2 in urine sedim...

Uncovering Modifier Genes of X-Linked Alport Syndrome Using a Novel Multiparent Mouse M...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455275
Journal of the American Society of Nephrology : JASN; Takemon Y, Wright V et. al.

May 29th, 2021 - Mutations in COL4A5 are responsible for 80% of cases of X-linked Alport Syndrome (XLAS). Although genes that cause AS are well characterized, people with AS who have similar genetic mutations present with a wide variation in the extent of kidney impairment and age of onset, suggesting the activities of modifier genes. We created a cohort of genetically diverse XLAS male and female mice using th...

Primary IgA nephropathy with nephrotic-range proteinuria in Chinese children.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154377
Medicine Zhao JL, Wang JJ et. al.

May 26th, 2021 - To investigate the clinicopathological features and outcomes of primary IgA nephropathy with nephrotic-range proteinuria in Chinese children. Patients with biopsy-proven IgA nephropathy and nephrotic-range proteinuria between January 2011 and December 2017 were included, and their proteinuria and renal function were followed up. A total of 90 patients were enrolled, and 21.1% (19/90) of them ha...

Comparison of conventional and non-invasive diagnostic tools for detecting Plasmodium f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140564
Infectious Diseases of Poverty; Apinjoh TO, Ntasin VN et. al.

May 24th, 2021 - Malaria remains a significant health challenge in sub-Saharan Africa, with early diagnosis critical to reducing its morbidity and mortality. Despite the increasing Plasmodium spp. diagnostic capabilities, access to testing is limited in some cases by the almost absolute requirement for blood from potentially infected subjects as the only sample source for all conventional methods. A rapid test ...

Progress toward Developing Sensitive Non-Sputum-Based Tuberculosis Diagnostic Tests: th...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288258
Journal of Clinical Microbiology; MacLean E, Nathavitharana RR

May 14th, 2021 - A highly accurate, non-sputum-based test for tuberculosis (TB) detection is a key priority for the field of TB diagnostics. A recent study in the Journal of Clinical Microbiology by Oreskovic and colleagues (J Clin Microbiol 59:e00074-21, 2021, https://doi.org/10.1128/JCM.00074-21) reports the performance of an optimized urine cell-free DNA (cfDNA) test using sequence-specific purification comb...

Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116001
Clinical and Translational Gastroenterology; Allegretti AS, Parada XV et. al.

May 13th, 2021 - Urinary neutrophil gelatinase-associated lipocalin (NGAL) has shown promise in differentiating acute tubular necrosis (ATN) from other types of acute kidney injuries (AKIs) in cirrhosis, particularly hepatorenal syndrome (HRS). However, NGAL is not currently available in clinical practice in North America. Urinary NGAL was measured in a prospective cohort of 213 US hospitalized patients with de...

Potential value of urine lateral-flow lipoarabinomannan (LAM) test for diagnosing tuber...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099085
PloS One; Schramm B, Nganaboy RC et. al.

May 6th, 2021 - Tuberculosis (TB) is a serious co-morbidity among children with severe acute malnutrition (SAM) and TB diagnosis remains particularly challenging in the very young. We explored whether, in a low HIV-prevalence setting, the detection of mycobacterial lipoarabinomannan (LAM) antigen in urine may assist TB diagnosis in SAM children, a pediatric population currently not included in LAM-testing reco...

The frequency of cytomegalovirus non-ELR UL146 genotypes in neonates with congenital CM...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077815
BMC Infectious Diseases; Berg C, Rosenkilde MM et. al.

Apr 28th, 2021 - Congenital cytomegalovirus disease (cCMV) is common and can be fatal or cause severe sequelae. Circulating strains of cytomegalovirus carry a high number of variable or disrupted genes. One of these is UL146, a highly diverse gene with 14 distinct genotypes encoding a CXC-chemokine involved in viral dissemination. UL146 genotypes 5 and 6 lack the conserved ELR motif, potentially affecting strai...

Verifying Clinically Derived Reference Intervals for Daily Excretion Rates of Fractiona...
https://doi.org/10.1093/ajcp/aqab006
American Journal of Clinical Pathology; Doyle K, Frank EL

Apr 22nd, 2021 - Biochemical testing of urinary metanephrines is useful in the diagnosis and monitoring of pheochromocytoma and paragangliomas. We investigated the feasibility of mixture decomposition (ie, indirect) methods in verifying clinically derived reference intervals for urinary deconjugated metanephrine metabolites. Urinary 24-hour metanephrine and normetanephrine excretion results were extracted from ...

Evaluation of hTERT, KRT7, and survivin in urine for noninvasive detection of bladder c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054358
BMC Urology; Yahyazadeh R, Bashash D et. al.

Apr 21st, 2021 - Transitional cell carcinoma (TCC) of the bladder is the second most common genitourinary malignancy. Because of the low sensitivity of urinary cytology and the invasiveness and expense of frequent cystoscopies for the detection of low-grade superficial lesions, we aim to establish a sensitive molecular approach to detect bladder cancer noninvasively. Voided urine samples were collected from 80 ...

Comparison of 3 anti-PLA2R inmmunoassaysfor the diagnosis of idiopathic membranous neph...
https://doi.org/10.1016/j.clim.2021.108729
Clinical Immunology (Orlando, Fla.); Nieto-Gañán I, Rita CG et. al.

Apr 20th, 2021 - Membranous nephropathy (MN) is one of the most frequent causes of nephrotic syndrome. Renal biopsy is nowadays the gold standard for the diagnosis of MN. The presence of circulating PLA2R antibody is a very specific tool for the diagnosis of this disease, especially associated with primary or idiopathic MN (IMN), even though it can be also found in a small proportion of patients with secondary ...

Inpatient Measurements of Urine Metanephrines are Indistinguishable from Pheochromocyto...
https://doi.org/10.1016/j.amjmed.2021.03.015
The American Journal of Medicine; Kline GA, Boyd J et. al.

Apr 18th, 2021 - Pheochromocytoma is a rare cause of acute cardiovascular disease; however, any severe illness may have high catecholamines, simulating pheochromocytoma. We determined the spectrum of urine metanephrines from inpatient and outpatient collections without pheochromocytoma, compared with confirmed pheochromocytoma patients. Retrospective analysis using centralized laboratory data serving all outpat...

Discrimination of SARS-CoV-2 infected patient samples by detection dogs: A proof of con...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046346
PloS One; Essler JL, Kane SA et. al.

Apr 15th, 2021 - While the world awaits a widely available COVID-19 vaccine, availability of testing is limited in many regions and can be further compounded by shortages of reagents, prolonged processing time and delayed results. One approach to rapid testing is to leverage the volatile organic compound (VOC) signature of SARS-CoV-2 infection. Detection dogs, a biological sensor of VOCs, were utilized to inves...