About 1,677,328 results

Germline Variants Identified in Patients with Early-onset Renal Cell Carcinoma Referred for Germline Genetic Testing
European Urology Oncology; Truong H

Oct 12th, 2021 - Despite guidelines recommending genetic counseling for patients with early-onset renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations and clinical associations in patients with early-onset RCC are lacking.

Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants
BioRxiv Tada T, Zhou H et. al.

Jul 19th, 2021 - The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible decreases in vaccine efficacy. Here, neutralizing antibody titers elicited by mRNA-based and an adenoviral vector-based vaccine against variant pseudotyped viruses were compared.

DSHS Statement on Monkeypox Investigation
Texas Health and Human Services

Jul 16th, 2021 - The Texas Department of State Health Services is working with Dallas County Health and Human Services and the CDC to investigate a single case of monkeypox virus infection in a Dallas County resident who recently returned from Nigeria. The patient is isolated in the hospital, and the public health investigation has identified a few people who may have been exposed in Dallas and are monitoring t...

CDC and Texas Confirm Monkeypox In U.S. Traveler
Centers for Disease Control and Prevention (CDC)

Jul 16th, 2021 - The Centers for Disease Control and Prevention (CDC) and the Texas Department of State Health Services confirmed on July 15 a case of human monkeypox in a U.S. resident who recently traveled from Nigeria to the United States. The person is currently hospitalized in Dallas. CDC is working with the airline and state and local health officials to contact airline passengers and others who may have ...

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report
Medrxiv Atmar RL, .

Oct 13th, 2021 - Background: While Coronavirus disease 2019 (Covid-19) vaccines are highly effective, breakthrough infections are occurring. Booster vaccinations have recently received emergency use authorization (EUA) for certain populations but are restricted to homologous mRNA vaccines. We evaluated homologous and heterologous booster vaccination in persons who had received an EUA Covid-19 vaccine regimen.

Fauci in the Doghouse; SCOTUS to Review Texas Abortion Law; Public Health's Downfall

Oct 25th, 2021 - Note that some links may require registration or subscription. NIH officials admitted that they funded research to the Wuhan Institute of Virology that enhanced bat coronaviruses, but insisted there were too many genetic differences for one of those viruses to have led to the origin of the COVID pandemic. (Vanity Fair) Meanwhile, 24 legislators sent a letter to NIAID Director Anthony Fauci, MD,...

Psoriasis patients with more severe disease at higher risk of developing PsA

Oct 24th, 2021 - Key clinical point: Patients with psoriasis with the most severe disease were at highest risk of developing psoriatic arthritis (PsA), highlighting the need for regular screening for signs and symptoms of PsA. Major finding: Overall incidence of PsA in patients with mild, moderate, and severe psoriasis was 2.

PsA: Phase 3 confirms rapid and significant response of secukinumab on synovitis

Oct 24th, 2021 - Key clinical point: Evaluation with power Doppler ultrasound revealed a rapid and significant reduction of synovitis in patients with psoriatic arthritis (PsA) upon treatment with secukinumab. Major finding : At week 12, the adjusted mean change in the global European League Against Rheumatism (EULAR) and the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) (EULAR-OMERACT) syn.

Risk classification at diagnosis predicts post-HCT outcomes in AML

Oct 24th, 2021 - Key clinical point: Risk classification at acute myeloid leukemia (AML) diagnosis predicted clinical outcomes in patients with or without KMT2A-rearranged AML who underwent allogeneic hematopoietic cell transplant (HCT) in the first complete remission (CR1). Major finding: Transplanted patients with KMT2A-rearranged and adverse-risk AML had worse overall survival (hazard ratio [HR] 1.

LDL cholesterol target achievement in heterozygous familial hypercholesterolemia patien...
International Journal of Cardiology; Rizos CV, Skoumas I et. al.

Oct 24th, 2021 - The 2019 European guidelines (ESC/EAS) for the treatment of dyslipidaemias recommend more aggressive targets for low-density lipoprotein cholesterol (LDL-C) in patients with familial hypercholesterolemia (FH). Current lipid-lowering treatment is often inadequate to achieve these targets. Data from the HELLAS-FH registry were analysed to assess achievement of LDL-C targets in adults with FH base...

Evaluating potential of multi-parametric MRI using co-registered histology: Application...
Magnetic Resonance Imaging; Al-Mubarak H, Vallatos A et. al.

Oct 24th, 2021 - Conventional MRI fails to detect regions of glioblastoma cell infiltration beyond the contrast-enhanced T1 solid tumor region, with infiltrating tumor cells often migrating along host blood vessels. MRI is capable of generating a range of image contrasts which are commonly assessed individually by qualitative visual inspection. It has long been hypothesized that better diagnoses could be achiev...

Intestinal obstruction secondary to malformation in a child with Mayer-Rokitansky-Küste...
Journal of Pediatric and Adolescent Gynecology; Tan LJ, Tan GC et. al.

Oct 24th, 2021 - Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is a congenital disorder characterized by underdevelopment of the uterus and vagina. A 4-year-old girl was declared dead on arrival to the hospital with a history of chronic constipation since birth. Postmortem examination showed Müllerian remnants attached to abnormal fibrous tissue. The fibrous tissue extended from the descending colon to the rec...

Awake microsurgical resection for optochiasmatic cavernous malformation.
World Neurosurgery; Alejandro SA, Paganelli SL et. al.

Oct 24th, 2021 - The cavernous malformations (CM) affect approximately 0.5% of the population, with only a limited portion being located in the optic nerve and chiasma. The clinical presentation is determined by their locations. In the optochiasmatic CM, the acute visual disturbance is the most common presentation. Chronically, many show a progressive visual loss, chronic headache, and pituitary disturbances. T...

Mitochondrial Iron-Sulfur Cluster Biogenesis and Neurological Disorders.
Mitochondrion Selvanathan A, Parayil Sankaran B

Oct 24th, 2021 - Iron-sulfur clusters (ISCs) are highly conserved moieties embedded into numerous crucial proteins in almost all bacteria, plants and mammals. As such, ISC biosynthesis is critical to cellular function. The pathway was first characterized in bacteria by the late 1990s, and over the subsequent 20 years there has been increasing understanding of its components in humans. Defects in ISC pathway com...

Molecular signature of brain arteriovenous malformation hemorrhage: a systematic review.
World Neurosurgery; Germans MR, Sun W et. al.

Oct 24th, 2021 - The mechanisms of brain arteriovenous malformation (bAVM) development, formation and progress are still poorly understood. By gaining more knowledge about the molecular signature of bAVM in relation to hemorrhage, we might be able to find biomarkers associated with this serious complication, which can function as a goal for further research and can be a potential target for gene therapy. To pro...

Anti-TNFα vs thiopurines for the prevention of postoperative recurrence in Crohn's dise...
Clinical Gastroenterology and Hepatology : the Official C... Beelen EMJ, Nieboer D et. al.

Oct 24th, 2021 - The superiority of anti-TNFα agents to thiopurines for the prevention of postoperative recurrence of Crohn's disease (CD) after ileocolonic resection remains controversial. In this meta-analysis of individual participant data (IPD-MA), the effect of both strategies was compared and assessed after risk stratification. After a systematic literature search, IPD were requested from randomized contr...

Metabolic syndrome and risk of gastrointestinal cancers: an investigation using large-s...
Clinical Gastroenterology and Hepatology : the Official C... Rothwell JA, Jenab M et. al.

Oct 24th, 2021 - Gastrointestinal cancer risk is influenced by the presence of metabolic syndrome [MetS]. However, previous epidemiological studies lacked full serological biomarker data for the classification of MetS and the interaction of MetS with germline cancer risk variants is unknown. We investigated the associations between MetS and gastrointestinal cancer risk (overall, colorectal, pancreatic, esophage...

Electrical status epilepticus in sleep: The role of thalamus in etiopathogenesis.
Seizure Kilic H, Yilmaz K et. al.

Oct 24th, 2021 - In patients diagnosed with epilepsy, decreased ratio of N-acetyl aspartate to creatine (NAA/Cr) measured in magnetic resonance spectroscopy (MRS) has been accepted as a sign of neuronal cell loss or dysfunction. In this study, we aimed to determine whether a similar neuronal cell loss is present in a group of encephalopathy with electrical status epilepticus in sleep (ESES) patients METHODS: We...

Clinical evaluation of the Procleix SARS-CoV-2 assay, a sensitive, high-throughput test...
Diagnostic Microbiology and Infectious Disease; Sauleda S, Palacios L et. al.

Oct 24th, 2021 - Testing is crucial in controlling COVID-19. The Procleix® SARS-CoV-2 assay, a transcription-mediated amplification nucleic acid test that runs on an automated system, was evaluated using inactivated virus and clinical samples. The sensitivity of the assay was assessed using heat-inactivated SARS-CoV-2 and compared to 3 other tests. Clinical validation utilized 2 sets of samples: (1) Nasal, naso...