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About 47,840 results

Associations between physical activity prior to infection and COVID-19 disease severity...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058293
BMJ Open; Malisoux L, Backes A et. al.

Apr 30th, 2022 - To investigate if the physical activity (PA) prior to infection is associated with the severity of the disease in patients positively tested for COVID-19, as well as with the most common symptoms. A cross-sectional study using baseline data from a prospective, hybrid cohort study (Predi-COVID) in Luxembourg. Data were collected from May 2020 to June 2021. Real-life setting (at home) and hospita...

Zika virus-induced TNF-α signaling dysregulates expression of neurologic genes associat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036774
Journal of Neuroinflammation; Kung PL, Chou TW et. al.

Apr 26th, 2022 - Zika virus (ZIKV) is an emerging flavivirus of global concern. ZIKV infection of the central nervous system has been linked to a variety of clinical syndromes, including microcephaly in fetuses and rare but serious neurologic disease in adults. However, the potential for ZIKV to influence brain physiology and host behavior following apparently mild or subclinical infection is less well understo...

Epstein-Barr Virus and Multiple Sclerosis: New Light on an Old Idea BjornevikKCorteseMH...
https://doi.org/10.1177/10738584221090209
The Neuroscientist : a Review Journal Bringing Neurobiolo...

Apr 21st, 2022 - Epstein-Barr Virus and Multiple Sclerosis: New Light on an Old Idea BjornevikKCorteseMHealyBCKuhleJMinaMJLengY, and others. 2022. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science375(6578):296-301. LanzTVBrewerRCHoPPMoonJSJudeKMFernandezD, and others. Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM. Nature...

WHO Urges Monitoring SARS-CoV-2 in Wildlife to Prevent Animal Reservoirs.
https://doi.org/10.1001/jama.2022.5654
JAMA Larkin HD

Apr 20th, 2022 - WHO Urges Monitoring SARS-CoV-2 in Wildlife to Prevent Animal Reservoirs.|2022|Larkin HD,|virology,diagnosis,epidemiology,virology,epidemiology,virology,

Single-Cell Landscape of Lungs Reveals Key Role of Neutrophil-Mediated Immunopathology ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093099
Journal of Virology; Zheng XS, Wang Q et. al.

Apr 15th, 2022 - Due to the limitation of human studies with respect to individual difference or the accessibility of fresh tissue samples, how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in pathological complications in lung, the main site of infection, is still incompletely understood. Therefore, physiologically relevant animal models under realistic SARS-CoV-2 infection con...

Pathological Characteristics of Echovirus 30 Infection in a Mouse Model.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093115
Journal of Virology; Li J, Zhang G et. al.

Apr 15th, 2022 - Echovirus 30 (E30), a member of species B enterovirus, is associated with outbreaks of aseptic meningitis and has become a global health emergency. However, the pathogenesis of E30 remains poorly understood due to the lack of appropriate animal models. In this study, we established a mouse infection model to explore the pathogenicity of E30. The 2-day-old IFNAR-/- mice infected with E30 strain ...

Two Conserved Phenylalanine Residues in the E1 Fusion Loop of Alphaviruses Are Essentia...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093095
Journal of Virology; Lucas CJ, Davenport BJ et. al.

Apr 14th, 2022 - Alphaviruses infect cells by a low pH-dependent fusion reaction between viral and host cell membranes that is mediated by the viral E1 glycoprotein. Most reported alphavirus E1 sequences include two phenylalanines (F87 and F95) in the fusion loop, yet the role of these residues in viral infectivity remains to be defined. Following introduction of wild type (WT), E1-F87A, and E1-F95A chikungunya...

Pharmacological Targeting of Sphingosine Kinases Impedes HIV-1 Infection of CD4 T Cells...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093127
Journal of Virology; Resop RS, Bosque A

Apr 13th, 2022 - Sphingosine-1-phosphate (S1P) is a sphingolipid modulator of a myriad of cellular processes, and therapeutic targeting of S1P signaling is utilized clinically to treat multiple sclerosis. We have previously shown that functional antagonism of S1P receptors reduces cell-free, cell-to-cell, and latent HIV-1 infection in primary CD4 T cells. In this work, we examined whether targeting sphingosine ...

Zika Virus Induces Mitotic Catastrophe in Human Neural Progenitors by Triggering Unsche...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093132
Journal of Virology; Rychlowska M, Agyapong A et. al.

Apr 13th, 2022 - Vertical transmission of Zika virus (ZIKV) leads with high frequency to congenital ZIKV syndrome (CZS), whose worst outcome is microcephaly. However, the mechanisms of congenital ZIKV neurodevelopmental pathologies, including direct cytotoxicity to neural progenitor cells (NPC), placental insufficiency, and immune responses, remain incompletely understood. At the cellular level, microcephaly ty...

Cardiovascular signatures of COVID-19 predict mortality and identify barrier stabilizin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989492
EBioMedicine Gustafson D, Ngai M et. al.

Apr 12th, 2022 - Endothelial cell (EC) activation, endotheliitis, vascular permeability, and thrombosis have been observed in patients with severe coronavirus disease 2019 (COVID-19), indicating that the vasculature is affected during the acute stages of SARS-CoV-2 infection. It remains unknown whether circulating vascular markers are sufficient to predict clinical outcomes, are unique to COVID-19, and if vascu...

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989215
PloS One; Thi Cam Huong N, Trung NQ et. al.

Apr 8th, 2022 - Chronic hepatitis B virus (CHB) infection is a major health problem and leading cause of hepatocellular carcinoma (HCC) worldwide. Several point and deletion mutations on the PreS/S gene have been intensively considered associated with HCC. This study aimed to describe the characteristics of HBV PreS/S mutations in Vietnamese CHB-infected patients and their association with HCC. This cross-sect...

SARS-CoV-2 nsp5 Exhibits Stronger Catalytic Activity and Interferon Antagonism than Its...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044939
Journal of Virology; Chen J, Li Z et. al.

Apr 8th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose an enormous threat to economic activity and public health worldwide. Previous studies have shown that the nonstructural protein 5 (nsp5, also called 3C-like protease) of alpha- and deltacoronaviruses cleaves Q231 of the NF-κB essential modulator (NEMO), a key kinase in the RIG-I-like receptor pathway, to inhibit type...

Comparison of different sequencing techniques for identification of SARS-CoV-2 variants...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979425
PloS One; Ranasinghe D, Jayadas TTP et. al.

Apr 5th, 2022 - As different SARS-CoV-2 variants emerge and with the continuous evolvement of sub lineages of the delta variant, it is crucial that all countries carry out sequencing of at least >1% of their infections, in order to detect emergence of variants with higher transmissibility and with ability to evade immunity. However, due to limited resources as many resource poor countries are unable to sequenc...

The calcium channel inhibitor lacidipine inhibits Zika virus replication in neural prog...
https://doi.org/10.1016/j.antiviral.2022.105313
Antiviral Research; Bezemer B, van Cleef KWR et. al.

Apr 4th, 2022 - After decades of being considered non-pathogenic, Zika virus (ZIKV) emerged as an important threat to human health during the epidemic of 2015-2016. ZIKV infections are usually asymptomatic, but can cause Guillain-Barré syndrome in adults and microcephaly in newborns. As there are currently no approved antiviral drugs against ZIKV, we tested anti-ZIKV activity of compounds from the NIH Clinical...

Acute Myocardial Injury Assessed by High-Sensitive Cardiac Troponin Predicting Severe O...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979852
Clinical and Applied Thrombosis/hemostasis : Official Jou... Laouan Brem F, Chaymae M et. al.

Apr 2nd, 2022 - Cardiac injury has been linked to a poor prognosis during COVID-19 disease. Nevertheless, the risk factors associated are yet to be thoroughly investigated. We sought to compare demographical characteristics and in-hospital outcomes in patients infected by the SARS-CoV-2 with and without cardiac injury, to further investigate the prevalence of acute cardiac injury as well as its impact on their...

SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spread...
https://doi.org/10.1073/pnas.2119680119
Proceedings of the National Academy of Sciences of the Un... Morrison CB, Edwards CE et. al.

Mar 31st, 2022 - Significance Gaining insights into severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) high transmissibility and the role played by inflammatory mediators in viral proliferation are critical to investigating new therapeutic targets against COVID-19. Electron microscopy reveals important SARS-CoV-2 features, including the combination of large, rapidly released viral clusters and the mas...

Possible Cross-Reactivity of Feline and White-Tailed Deer Antibodies against the SARS-C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044950
Journal of Virology; Hancock TJ, Hickman P et. al.

Mar 31st, 2022 - In late 2019, a novel coronavirus began circulating within humans in central China. It was designated SARS-CoV-2 because of its genetic similarities to the 2003 SARS coronavirus (SARS-CoV). Now that SARS-CoV-2 has spread worldwide, there is a risk of it establishing new animal reservoirs and recombination with native circulating coronaviruses. To screen local animal populations in the United St...

The Significance of CD109 Expression in Oropharyngeal Squamous Cell Carcinoma.
https://doi.org/10.21873/anticanres.15687
Anticancer Research; Tsutsumi S, Momiyama K et. al.

Mar 30th, 2022 - Up-regulation of CD109 occurs in malignant tumours, although its role is unknown. Here we aimed to evaluate the significance of CD109 expression in oropharyngeal squamous cell carcinoma (OPSCC). Immunohistochemical analysis was performed to assess CD109 expression in 169 patients with OPSCC. We assessed the effects of small interfering RNA (siRNA)-mediated inhibition of CD109 expression on the ...

Phylogenetic analysis of 17271 Indian SARS-CoV-2 genomes to identify temporal and spati...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959188
PloS One; Ghosh N, Nandi S et. al.

Mar 29th, 2022 - The second wave of SARS-CoV-2 has hit India hard and though the vaccination drive has started, moderate number of COVID affected patients is still present in the country, thereby leading to the analysis of the evolving virus strains. In this regard, multiple sequence alignment of 17271 Indian SARS-CoV-2 sequences is performed using MAFFT followed by their phylogenetic analysis using Nextstrain....

Structural Basis for Human Receptor Recognition by SARS-CoV-2 Omicron Variant BA.1.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044962
Journal of Virology; Geng Q, Shi K et. al.

Mar 29th, 2022 - The highly contagious and fast-spreading omicron variant of SARS-CoV-2 infects the respiratory tracts efficiently. The receptor-binding domain (RBD) of the omicron spike protein recognizes human angiotensin-converting enzyme 2 (ACE2) as its receptor and plays a critical role in the tissue tropism of SARS-CoV-2. Here, we showed that the omicron RBD (strain BA.1) binds to ACE2 more strongly than ...