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About 48,975 results

Ferrobotic swarms enable accessible and adaptable automated viral testing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645323
Nature Lin H, Yu W et. al.

Nov 10th, 2022 - Expanding our global testing capacity is critical to preventing and containing pandemics1-9. Accordingly, accessible and adaptable automated platforms that in decentralized settings perform nucleic acid amplification tests resource-efficiently are required10-14. Pooled testing can be extremely efficient if the pooling strategy is based on local viral prevalence15-20...

Ataxia Telangiectasia-Mutated Is Activated but Not Required for Productive Autographa c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682986
Journal of Virology; Erickson JR, Kalejta RF et. al.

Nov 1st, 2022 - Multiplication of the invertebrate DNA baculoviruses activates the host DNA damage response (DDR), which promotes virus DNA replication. DDR signaling is initiated by the host insect's phosphatidylinositol-3 kinase-related kinases (PIKKs), including ataxia telangiectasia-mutated kinase (ATM). Like other PIKKs, ATM phosphorylates an array of host DDR proteins at serine/threonine glutamine (S/TQ)...

Host 5'-3' Exoribonuclease XRN1 Acts as a Proviral Factor for Measles Virus Replication...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683022
Journal of Virology; BenDavid E, Pfaller CK et. al.

Oct 28th, 2022 - Many negative-sense RNA viruses, including measles virus (MeV), are thought to carry out much of their viral replication in cytoplasmic membraneless foci known as inclusion bodies (IBs). The mechanisms by which IBs facilitate efficient viral replication remain largely unknown but may involve an intricate network of regulation at the host-virus interface. Viruses are able to modulate such intera...

Delayed encephalopathy after COVID-19: A case series of six patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592135
Medicine Akimoto T, Hara M et. al.

Oct 26th, 2022 - Acute encephalopathy is a severe neurological complication of coronavirus disease 2019 (COVID-19). Most cases of acute encephalopathy associated with COVID-19 occur within several weeks of COVID-19 onset. We describe a case series of 6 patients who developed delayed encephalopathy (DE) after COVID-19. We evaluated patients who recovered from COVID-19 and showed acute disturbance of consciousnes...

Association of mRNA Vaccination With Clinical and Virologic Features of COVID-19 Among ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579910
JAMA , Thompson MG et. al.

Oct 19th, 2022 - Data on the epidemiology of mild to moderately severe COVID-19 are needed to inform public health guidance. To evaluate associations between 2 or 3 doses of mRNA COVID-19 vaccine and attenuation of symptoms and viral RNA load across SARS-CoV-2 viral lineages. A prospective cohort study of essential and frontline workers in Arizona, Florida, Minnesota, Oregon, Texas, and Utah with COVID-19 infec...

Manipulation of Interleukin-6 (IL-6) and Transforming Growth Factor Beta-1(TGFβ-1) towa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550071
PloS One; Badshah Y, Shabbir M et. al.

Oct 11th, 2022 - Hepatocellular carcinoma (HCC) is the most common liver malignancy. Early diagnosis of HCC has always been challenging. This study aims to assess the pathogenicity and the prevalence of IL-6 -174G/C (rs1800795) and TGFβ-1 +29C/T (rs1800470) polymorphisms in HCV-infected HCC patients. Experimental strategies are integrated with computational approaches to analyse the pathogenicity of the TGFβ-1 ...

Omicron variant of SARS-CoV-2 infection elicits cross-protective immunity in people who...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551331
International Journal of Immunopathology and Pharmacology; Chowdhury S, Chowdhury MS et. al.

Oct 11th, 2022 - The B.1.1.529 (Omicron) variant of SARS-CoV-2 is the most antigenically unique SARS-CoV-2 variant of concern to date, which is currently widespread across the world. Omicron variant and its sublineages contain a plethora of mutations than other variants of concern, which increases their transmissibility and virulence. Concerns regarding potential immunological evasion have been reignited by eme...

Insights into pandemic respiratory viruses: manipulation of the antiviral interferon re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472579
Current Opinion in Immunology; Liu G, Gack MU

Oct 11th, 2022 - The outbreak of the COVID-19 pandemic one year after the centennial of the 1918 influenza pandemic reaffirms the catastrophic impact respiratory viruses can have on global health and economy. A key feature of SARS-CoV-2 and influenza A viruses (IAV) is their remarkable ability to suppress or dysregulate human immune responses. Here, we summarize the growing knowledge about the interplay of SARS...

SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533993
Nature Kee J, Thudium S et. al.

Oct 6th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of 2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID-19), in part because of its ability to effectively suppress host cell responses1-3. In rare cases, viral proteins dampen antiviral responses by mimicking critical regions of human histone proteins4-8, particularly those containing ...

The introduction of mutations in the wild type coxsackievirus B3 (CVB3) IRES RNA leads ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529112
PloS One; Gharbi J, Almalki MA et. al.

Oct 4th, 2022 - Coxsackievirus B3 (CVB3) is a principal causative agent of viral myocarditis, meningitis and pancreatitis. There is no vaccine available for clinical use. It has been demonstrated that the primary molecular determinant of virulence phenotype is located in the 5' UTR of the viral genome. Translation initiation of CVB3 RNA is directed by the IRES element situated in the 5'UTR. In the present stud...

Systematic evaluation of plasma signaling cascades by functional proteomics approaches:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537801
Proteomics. Clinical Applications; Juanes-Velasco P, García-Vaquero ML et. al.

Sep 29th, 2022 - Acute phase reactants (APRs) play a critical role in inflammation. The difference in their physiological functions or the different dynamic ranges of these proteins in plasma makes it difficult to detect them simultaneously and to use several of these proteins as a tool in clinical practice. A novel multiplex assay has been designed and optimized to carry out a high-throughput and simultaneous ...

Long-term Household Contamination With Monkeypox Virus Investigated.
https://doi.org/10.1001/jama.2022.14726
JAMA Kuehn BM

Sep 28th, 2022 - Long-term Household Contamination With Monkeypox Virus Investigated.|2022|Kuehn BM,|virology,transmission,isolation & purification,

Use of convalescent plasma in pregnant women with early stage COVID-19 infection in a t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509581
BMC Pregnancy and Childbirth; Adan H, Harb D et. al.

Sep 27th, 2022 - The use of COVID-19 convalescent plasma (CCP) for the treatment of SARS-CoV-2 infection in pregnancy is intriguing in view of its safety profile in pregnancy and historical precedence of the use of plasma for other viral illnesses. This study aimed to evaluate the use of CCP in pregnant women with early COVID-19 infection. This is a retrospective case series study. We have included seven pregna...

Restricted Recruitment of NK Cells with Impaired Function Is Caused by HPV-Driven Immun...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555148
Journal of Virology; Wang W, Xi Y et. al.

Sep 27th, 2022 - Laryngopharynx epithelium neoplasia induced by HPV6/11 infection in juvenile-onset recurrent respiratory papillomatosis (JO-RRP) causes a great health issue characteristic of frequent relapse and aggressive disease progression. Local cell-mediated immunity shaped by the recruitment and activation of cytotoxic effector cells is critical for viral clearance. In this study, we found that NK cells ...

Brain neuronal and glial damage during acute COVID-19 infection in absence of clinical ...
https://doi.org/10.1136/jnnp-2022-329933
Journal of Neurology, Neurosurgery, and Psychiatry; Plantone D, Locci S et. al.

Sep 23rd, 2022 - To assess whether SARS-CoV-2 infection may affect the central nervous system, specifically neurons and glia cells, even without clinical neurological involvement. In this single centre prospective study, serum levels of neurofilament light chain (sNfL) and glial fibrillar acidic protein (sGFAp) were assessed using SimoaTM assay Neurology 2-Plex B Assay Kit, in 148 hospitalised patients with COV...

Beta Human Papillomavirus 8 E6 Induces Micronucleus Formation and Promotes Chromothripsis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555153
Journal of Virology; Dacus D, Stancic S et. al.

Sep 22nd, 2022 - Cutaneous beta genus human papillomaviruses (β-HPVs) are suspected to promote the development of nonmelanoma skin cancer (NMSC) by destabilizing the host genome. Multiple studies have established the genome destabilizing capacities of β-HPV proteins E6 and E7 as a cofactor with UV. However, the E6 protein from β-HPV8 (HPV8 E6) induces tumors in mice without UV exposure. Here, we examined a UV-i...

Common human genetic variants of APOE impact murine COVID-19 mortality.
https://doi.org/10.1038/s41586-022-05344-2
Nature Ostendorf BN, Patel MA et. al.

Sep 22nd, 2022 - Clinical outcomes of severe acute respiratory syndrome 2 (SARS-CoV-2) infection are highly heterogeneous, ranging from asymptomatic infection to lethal coronavirus disease 2019 (COVID-19). The factors underlying this heterogeneity remain insufficiently understood. Genetic association studies have suggested that genetic variants contribute to the heterogeneity of COVID-19 outcomes, but the under...

Intestinal Norovirus Binding Patterns in Nonsecretor Individuals.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555158
Journal of Virology; Tarris G, Estienney M et. al.

Sep 20th, 2022 - Human norovirus (HuNoV) infection is associated with an active FUT2 gene, which characterizes the secretor phenotype. However, nonsecretor individuals are also affected by HuNoV infection although in a lesser proportion. Here, we studied GII.3, GII.4, and GII.17 HuNoV interactions in nonsecretor individuals using virus-like particles (VLPs). Only GII.4 HuNoV specifically interacted with nonsecr...

The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Pr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555207
Journal of Virology; Gellenoncourt S, Saunders N et. al.

Sep 20th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remained genetically stable during the first 3 months of the pandemic, before acquiring a D614G spike mutation that rapidly spread worldwide and then generating successive waves of viral variants with increasingly high transmissibility. We set out to evaluate possible epistatic interactions between the early-occurring D614G mutation a...

Enterovirus 3C Protease Cleaves TRIM7 To Dampen Its Antiviral Activity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555159
Journal of Virology; Fan W, McDougal MB et. al.

Sep 16th, 2022 - Mammalian TRIM7 is an antiviral protein that inhibits multiple human enteroviruses by degrading the viral 2BC protein. Whether TRIM7 is reciprocally targeted by enteroviruses is not known. Here, we report that the 3C protease (3Cpro) from two enteroviruses, coxsackievirus B3 (CVB3) and poliovirus, targets TRIM7 for cleavage. CVB3 3Cpro cleaves TRIM7 at glutamine 24 (Q24), resulting in a truncat...