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About 43,235 results

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry ...
https://doi.org/10.1073/pnas.2108728118
Proceedings of the National Academy of Sciences of the Un... Mahoney M, Damalanka VC et. al.

Oct 13th, 2021 - The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug discovery. This protease activates the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and of other coronaviruses and is essential for viral spread in the lung. Utilizing rational structure-based drug design (SBDD) coupled to substrate specificity screening of TMPRSS2, we ha...

Real-time quantification of the transmission advantage associated with a single mutatio...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495436
BMC Infectious Diseases; Zhao S, Lou J et. al.

Oct 9th, 2021 - The COVID-19 pandemic poses serious threats to global health, and the emerging mutation in SARS-CoV-2 genomes, e.g., the D614G substitution, is one of the major challenges of disease control. Characterizing the role of the mutation activities is of importance to understand how the evolution of pathogen shapes the epidemiological outcomes at population scale. We developed a statistical framework...

Distribution of SARS-CoV-2 Variants in a Large Integrated Health Care System - Californ...
https://doi.org/10.15585/mmwr.mm7040a4
MMWR. Morbidity and Mortality Weekly Report; Malden DE, Bruxvoort KJ et. al.

Oct 8th, 2021 - Data from observational studies demonstrate that variants of SARS-CoV-2, the virus that causes COVID-19, have evolved rapidly across many countries (1,2). The SARS-CoV-2 B.1.617.2 (Delta) variant of concern is more transmissible than previously identified variants,* and as of September 2021, is the predominant variant in the United States.† Studies characterizing the distribution and severity o...

COVID-19 Outbreaks at Youth Summer Camps - Louisiana, June-July 2021.
https://doi.org/10.15585/mmwr.mm7040e2
MMWR. Morbidity and Mortality Weekly Report; Tonzel JL, Sokol T

Oct 8th, 2021 - According to sequencing data reported by CDC, the highly transmissible B.1.617.2 (Delta) variant of SARS-CoV-2, the virus that causes COVID-19, has been the predominant lineage circulating in Louisiana since the week of June 20, 2021 (1). In Louisiana, the increased spread of the Delta variant corresponded with the start of the state's fourth and largest increase in average daily COVID-19 incid...

Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490365
Nature Communications; Ferren M, Favède V et. al.

Oct 6th, 2021 - SARS-CoV-2 has caused a global pandemic of COVID-19 since its emergence in December 2019. The infection causes a severe acute respiratory syndrome and may also spread to central nervous system leading to neurological sequelae. We have developed and characterized two new organotypic cultures from hamster brainstem and lung tissues that offer a unique opportunity to study the early steps of viral...

Humoral response after SARS-CoV-2 mRNA vaccines in dialysis patients: Integrating anti-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491898
PloS One; Bachelet T, Bourdenx JP et. al.

Oct 6th, 2021 - Dialysis patients are both the most likely to benefit from vaccine protection against SARS-CoV-2 and at the highest risk of not developing an immune response. Data from the medical field are thus mandatory. We report our experience with a BNT162b2-mRNA vaccine in a retrospective analysis of 241 dialysis patients including 193 who underwent anti-Spike-Protein-Receptor-Binding-Domain (RBD) IgG an...

Assessment of knowledge, attitude and practice toward COVID-19 and associated factors a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491949
PloS One; Yesse M, Muze M et. al.

Oct 6th, 2021 - COVID-19 is a pandemic respiratory disease caused by the highly contagious novel coronavirus (SARS-CoV 2). The disease is now quickly spreading around the world, resulting in ongoing coronavirus pandemic. Healthcare workers are more susceptible to COVID-19 infection than the general population due to frequent contact with infected individuals. This study was aimed to assess knowledge, attitude ...

Association between chronic hepatitis B infection and COVID-19 outcomes: A Korean natio...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491877
PloS One; Kang SH, Cho DH et. al.

Oct 6th, 2021 - We measured the association between underlying chronic hepatitis B (CHB) and antiviral use with infection rates among patients who underwent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing. In total, 204,418 patients who were tested for SARS-CoV-2 between January and June 2020 were included. For each case patient (n = 7,723) with a positive SARS-CoV-2 test, random controls ...

COVID-19 in pregnancy: placental pathological patterns and effect on perinatal outcome ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487453
Diagnostic Pathology; Giordano G, Petrolini C et. al.

Oct 5th, 2021 - COVID-19, the disease caused by the novel coronavirus SARS-CoV-2, is a severe systemic thrombotic syndrome that emerged in 2019, with an ensuing pandemic. To evaluate the impact of this disease on placental tissue and perinatal outcome, histological, immunohistochemical and ultrastructural analyses of placental tissue were performed for five cases of pregnant women with COVID-19. All five pregn...

Metabolic dysfunction associated fatty liver disease and coronavirus disease 2019: clin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487451
Lipids in Health and Disease; Xu Y, Yang X et. al.

Oct 5th, 2021 - The coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). At present, the COVID-19 has been prevalent worldwide for more than a year and caused more than four million deaths. Liver injury was frequently observed in patients with COVID-19. Recently, a new definition of metabolic dysfunction associated fatty liver disease (MAFLD) w...

Standardized preservation, extraction and quantification techniques for detection of fe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486790
Nature Communications; Natarajan A, Han A et. al.

Oct 3rd, 2021 - Patients with COVID-19 shed SARS-CoV-2 RNA in stool, sometimes well after their respiratory infection has cleared. This may be significant for patient health, epidemiology, and diagnosis. However, methods to preserve stool, and to extract and quantify viral RNA are not standardized. We test the performance of three preservative approaches at yielding detectable SARS-CoV-2 RNA: the OMNIgene-GUT ...

Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutatio...
https://doi.org/10.1038/s41467-021-26055-8 10.1038/s41586-021-03677-y 10.1038/s41564-020-0770-5 10.1093/infdis/jiu047 10.1038/s41564-021-00933-9 10.1038/s41467-020-18877-9 10.1002/cpz1.98 10.1016/j.cell.2020.09.032 10.1016/j.cell.2020.08.012 10.1038/s41586-020-2180-5 10.1016/j.jmb.2015.09.014 10.1038/s41598-021-83761-5 10.1016/j.molcel.2020.04.022 10.1016/j.cell.2020.02.058 10.1016/j.cell.2019.07.018 10.1056/NEJMc2031364 10.1038/s41586-021-03291-y 10.1038/s41591-020-0997-y 10.1016/S1473-3099(20)30635-6 10.1093/bioinformatics/bty407 10.3390/v12080895 10.1002/pro.3235 10.1093/molbev/mst010 10.1093/ve/vew007 10.1016/S0022-2836(05)80360-2 10.1093/molbev/msaa015 10.1007/BF00160154 10.1093/sysbio/syv083 10.1093/molbev/mss265 10.1371/journal.pbio.0040088 10.12688/wellcomeopenres.15770.1 10.1093/ve/vey016 10.7326/M20-0504 10.1371/journal.pcbi.1000520 10.1002/cjs.5550360302 10.1093/sysbio/syy032 10.1093/sysbio/syq010 10.1007/BF02101694 10.1093/sysbio/sys029
Nature Communications; Dudas G, Hong SL et. al.

Oct 3rd, 2021 - Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2 lineage - designated B.1.620 - discovered in Lithuania and carrying many mutations and deletions in the spike protein shared with widespread variants of concern (VOCs), including ...

Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers...
https://doi.org/10.1038/s41467-021-25985-7 10.1002/gch2.1018 10.1038/s41467-020-18877-9 10.1016/j.meegid.2007.08.001 10.1016/j.cell.2021.02.037 10.1093/bioinformatics/bty407 10.1093/bioinformatics/bty191 10.1093/ve/vex042 10.1093/ve/vey016 10.7326/M20-0504 10.1007/s00285-007-0120-8 10.1093/molbev/msq067 10.1093/bioinformatics/btw384 10.1093/ve/vev023
Nature Communications; Butera Y, Mukantwari E et. al.

Oct 1st, 2021 - COVID-19 transmission rates are often linked to locally circulating strains of SARS-CoV-2. Here we describe 203 SARS-CoV-2 whole genome sequences analyzed from strains circulating in Rwanda from May 2020 to February 2021. In particular, we report a shift in variant distribution towards the emerging sub-lineage A.23.1 that is currently dominating. Furthermore, we report the detection of the firs...

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is not detected in the vagin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483336
PloS One; Takmaz O, Kaya E et. al.

Oct 1st, 2021 - To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is present in the vagina of women diagnosed with coronavirus disease-19 (COVID-19) pneumonia. The study was conducted prospectively in a university affiliated hospital. Forty-one women of reproductive age whose nasopharyngeal PCR test were positive for SARS-CoV-2 and clinically diagnosed with pneumonia were includ...

Aerosol SARS-CoV-2 in hospitals and long-term care homes during the COVID-19 pandemic.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483369
PloS One; Mallach G, Kasloff SB et. al.

Oct 1st, 2021 - Few studies have quantified aerosol concentrations of SARS-CoV-2 in hospitals and long-term care homes, and fewer still have examined samples for viability. This information is needed to clarify transmission risks beyond close contact. We deployed particulate air samplers in rooms with COVID-19 positive patients in hospital ward and ICU rooms, rooms in long-term care homes experiencing outbreak...

Local topology and bifurcation hot-spots in proteins with SARS-CoV-2 spike protein as a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483365
PloS One; Peng X, Niemi AJ

Oct 1st, 2021 - Novel topological methods are introduced to protein research. The aim is to identify hot-spot sites where a bifurcation can alter the local topology of the protein backbone. Since the shape of a protein is intimately related to its biological function, a substitution that causes a bifurcation should have an enhanced capacity to change the protein's function. The methodology applies to any prote...

In vivo structure and dynamics of the SARS-CoV-2 RNA genome.
https://doi.org/10.1038/s41467-021-25999-1 10.1080/22221751.2020.1719902 10.1146/annurev-virology-100114-055218 10.1016/j.cell.2020.04.011 10.1128/JVI.79.4.2506-2516.2005 10.1128/JVI.01782-12 10.1128/JVI.78.2.980-994.2004 10.1128/JVI.01690-07 10.1016/j.virusres.2015.02.025 10.1371/journal.pbio.0030172 10.1074/jbc.AC120.013449 10.1016/j.cell.2021.02.008 10.1016/j.molcel.2016.04.028 10.1016/j.molcel.2009.09.039 10.1016/j.molcel.2014.03.049 10.1016/bs.aivir.2016.08.007 10.1128/JVI.00549-07 10.1042/BST20200670 10.1038/s41592-018-0121-0 10.1261/rna.076141.120 10.1128/JVI.00803-06 10.1093/nar/gkab119 10.1093/nar/gkaa1013 10.1038/s41592-021-01075-w 10.1016/j.cell.2013.03.043 10.1038/nbt.3289 10.1016/j.cell.2016.04.028 10.1073/pnas.1017386108 10.1186/s13073-020-00802-w 10.1186/s13059-014-0550-8 10.1016/j.molcel.2021.02.036 10.1126/science.1181369 10.1038/s41586-020-2249-1 10.1038/nature14450 10.1016/j.chom.2018.10.011 10.1038/s41467-019-09391-8 10.1126/sciadv.abb9153 10.1016/j.molcel.2016.04.030 10.1016/j.cell.2020.09.018 10.1016/j.ymeth.2013.10.015 10.1093/bioinformatics/bth349 10.1093/bioinformatics/btu268 10.1128/JVI.73.1.152-160.1999
Nature Communications; Zhang Y, Huang K et. al.

Sep 30th, 2021 - The dynamics of SARS-CoV-2 RNA structure and their functional relevance are largely unknown. Here we develop a simplified SPLASH assay and comprehensively map the in vivo RNA-RNA interactome of SARS-CoV-2 genome across viral life cycle. We report canonical and alternative structures including 5'-UTR and 3'-UTR, frameshifting element (FSE) pseudoknot and genome cyclization in both cells and viri...

Dialogue between Neuroinflammation and Neurodegenerative Diseases in COVID-19.
https://doi.org/10.1615/JEnvironPatholToxicolOncol.2021038365
Journal of Environmental Pathology, Toxicology and Oncolo... Chowdhury B, Sharma A et. al.

Sep 30th, 2021 - It has now been almost a year since the emergence of the deadly SARS-CoV-2 with millions of people losing their lives due to resultant COVID-19. Apart from the well-known consequences of respiratory illnesses, it has even effortlessly mapped itself into the nervous system through routes like blood, CSF, neurons, and olfactory cells. Interestingly, the interaction of SARS-CoV-2 with the nervous ...

Targeting novel coronavirus SARS-CoV-2 spike protein with phytoconstituents of Momordic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474883
Journal of Ovarian Research; Singh SK, Singh S et. al.

Sep 29th, 2021 - Infections by the SARS-CoV-2 virus causing COVID-19 are presently a global emergency. The current vaccination effort may reduce the infection rate, but strain variants are emerging under selection pressure. Thus, there is an urgent need to find drugs that treat COVID-19 and save human lives. Hence, in this study, we identified phytoconstituents of an edible vegetable, Bitter melon (Momordica ch...

Predictive symptoms for COVID-19 in the community: REACT-1 study of over 1 million people.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478234
PLoS Medicine; Elliott J, Whitaker M et. al.

Sep 29th, 2021 - Rapid detection, isolation, and contact tracing of community COVID-19 cases are essential measures to limit the community spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to identify a parsimonious set of symptoms that jointly predict COVID-19 and investigated whether predictive symptoms differ between the B.1.1.7 (Alpha) lineage (predominating as of April 2021 i...