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About 49,680 results

Headache as a COVID-19 onset symptom or Post-COVID symptom according to the SARS-CoV-2 ...
https://doi.org/10.1080/14737175.2023.2185138
Expert Review of Neurotherapeutics; Fernández-de-Las-Peñas C, Cuadrado ML et. al.

Mar 2nd, 2023 - COVID19 associated headaches are highly common and there is currently an unmet need to better understand their association with SARSCoV2 variants. Headaches are a prevalent symptom in the acute phase of COVID19 and are associated with a better prognosis and better immune response. They are also a relevant post-COVID symptom. This article analyses the differences in the prevalence of headache as...

Oncolytic Effect of a Recombinant Vesicular Stomatitis Virus Encoding a Tumor-suppresso...
https://doi.org/10.21873/anticanres.16264
Anticancer Research; Sakuda T, Kubo T et. al.

Mar 1st, 2023 - Attempts have been made to enhance treatment with vesicular stomatitis virus (VSV) for osteosarcoma. We have previously shown that VSV incorporated with miRNA143 enhanced the antitumor effect at some doses; however, the range of the doses was narrow. This has not been evaluated in vivo, and the synergistic effect of this antitumor effect in animals is unknown. The purpose of the study was to ev...

Elucidating the role of missense SNP of protein kinase C epsilon in HCV-induced hepatoc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926771
BMC Cancer; Rehman A, Shabbir M et. al.

Feb 15th, 2023 - The protein kinase C (PKC) family of serine/threonine kinases contains more than ten isozymes that are involved in multiple signaling pathways, including cell cycle regulation and carcinogenesis. The PKCε isozyme is an oncogene known to be upregulated in various signaling pathways involved in hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC). However, there is no known association ...

SARS-CoV-2 multi-antigen protein microarray for detailed characterization of antibody r...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910743
PloS One; Celikgil A, Massimi AB et. al.

Feb 10th, 2023 - Antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) target multiple epitopes on different domains of the spike protein, and other SARS-CoV-2 proteins. We developed a SARS-CoV-2 multi-antigen protein microarray with the nucleocapsid, spike and its domains (S1, S2), and variants with single (D614G, E484K, N501Y) or double substitutions (N501Y/Deletion69/70), allowing a...

D-dimer levels in non-COVID-19 ARDS and COVID-19 ARDS patients: A systematic review wit...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901787
PloS One; Tóth K, Fresilli S et. al.

Feb 7th, 2023 - Hypercoagulability and thrombo-inflammation are the main reasons for death in COVID-19 patients. It is unclear whether there is a difference between D-dimer levels in patients without or with COVID-19 acute respiratory distress syndrome (ARDS). We searched PubMed, EMBASE, and ClinicalTrails.gov databases looking for studies reporting D-dimer levels in patients without or with COVID-19 ARDS. Sec...

DDX3X Is Hijacked by Snakehead Vesiculovirus Phosphoprotein To Facilitate Virus Replica...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972964
Journal of Virology; Bei C, Zhang C et. al.

Feb 7th, 2023 - Asp-Glu-Ala-Asp (DEAD) box helicase 3 X-linked (DDX3X) plays important regulatory roles in the replication of many viruses. However, the role of DDX3X in rhabdovirus replication has seldomly been investigated. In this study, snakehead vesiculovirus (SHVV), a kind of fish rhabdovirus, was used to study the role of DDX3X in rhabdovirus replication. DDX3X was identified as an interacting partner o...

Structural basis for substrate selection by the SARS-CoV-2 replicase.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891196
Nature Malone BF, Perry JK et. al.

Feb 2nd, 2023 - The SARS-CoV-2 RNA-dependent RNA polymerase coordinates viral RNA synthesis as part of an assembly known as the replication-transcription complex (RTC)1. Accordingly, the RTC is a target for clinically approved antiviral nucleoside analogues, including remdesivir2. Faithful synthesis of viral RNAs by the RTC requires recognition of the correct nucleotide triphosphate (NTP) for incorporation int...

SARS-CoV-2 Uses Nonstructural Protein 16 To Evade Restriction by IFIT1 and IFIT3.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973020
Journal of Virology; Schindewolf C, Lokugamage K et. al.

Feb 2nd, 2023 - Understanding the molecular basis of innate immune evasion by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important consideration for designing the next wave of therapeutics. Here, we investigate the role of the nonstructural protein 16 (NSP16) of SARS-CoV-2 in infection and pathogenesis. NSP16, a ribonucleoside 2'-O-methyltransferase (MTase), catalyzes the transfer of a ...

Retinoblastoma Protein Is Required for Epstein-Barr Virus Replication in Differentiated...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972952
Journal of Virology; Myers JE, Schaal DL et. al.

Feb 1st, 2023 - Coinfection of human papillomavirus (HPV) and Epstein-Barr virus (EBV) has been detected in oropharyngeal squamous cell carcinoma. Although HPV and EBV replicate in differentiated epithelial cells, we previously reported that HPV epithelial immortalization reduces EBV replication within organotypic raft culture and that the HPV16 oncoprotein E7 was sufficient to inhibit EBV replication. A well-...

Hyperimmune immunoglobulin for people with COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887673
The Cochrane Database of Systematic Reviews; Kimber C, Valk SJ et. al.

Jan 27th, 2023 - Hyperimmune immunoglobulin (hIVIG) contains polyclonal antibodies, which can be prepared from large amounts of pooled convalescent plasma or prepared from animal sources through immunisation. They are being investigated as a potential therapy for coronavirus disease 2019 (COVID-19). This review was previously part of a parent review addressing convalescent plasma and hIVIG for people with COVID...

Sustained Mpox Proctitis with Primary Syphilis and HIV Seroconversion, Australia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973693
Emerging Infectious Diseases; Burdon RM, Atefi D et. al.

Jan 27th, 2023 - A 26-year-old man in Australia who has sex with men had severe perianal ulceration, proctitis, and skin lesions develop. Testing revealed primary syphilis, mpox, and primary HIV infection. Recent publications have documented severe mpox associated with HIV infection. Disruption of mucosal integrity by mpox lesions could enable HIV transmission and vice versa.

Virology under the Microscope-a Call for Rational Discourse.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972907
Journal of Virology; Goodrum F, Lowen AC et. al.

Jan 27th, 2023 - Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines and antivirals. Despite this long history, the COVID-19 pandemic has brought unprecedented attention to the field of virology. Some of this attention is focus...

Recurring episodes of bundle branch reentry ventricular tachycardia due to aortitis pre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875172
BMC Cardiovascular Disorders; Melchior SE, Schoos MM et. al.

Jan 26th, 2023 - SARS-CoV-2 may trigger both vasculitis and arrhythmias as part of a multisystem inflammatory syndrome described in children as well as in adults following COVID-19 infection with only minor respiratory symptoms. The syndrome denotes a severe dysfunction of one or more extra-pulmonary organ systems, with symptom onset approximately 2-5 weeks after the COVID-19 infection. In the present case, a s...

The Epstein-Barr Virus Glycoprotein BDLF2 Is Essential for Efficient Viral Spread in St...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972961
Journal of Virology; Walston JJ, Hayman IR et. al.

Jan 24th, 2023 - Epstein-Barr virus (EBV) is a ubiquitous human pathogen that infects the majority of the adult population regardless of socioeconomic status or geographical location. EBV primarily infects B and epithelial cells and is associated with different cancers of these cell types, such as Burkitt lymphoma and nasopharyngeal carcinoma. While the life cycle of EBV in B cells is well understood, EBV infec...

A SARS-CoV-2-Related Virus from Malayan Pangolin Causes Lung Infection without Severe D...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972989
Journal of Virology; Liu MQ, Lin HF et. al.

Jan 24th, 2023 - Coronavirus disease 2019 (COVID-19), which is caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the most severe emerging infectious disease in the current century. The discovery of SARS-CoV-2-related coronaviruses (SARSr-CoV-2) in bats and pangolins in South Asian countries indicates that SARS-CoV-2 likely originated from wildlife. To date, two SAR...

Digestive system infection by SARS‑CoV‑2: Entry mechanism, clinical symptoms and expres...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911086
International Journal of Molecular Medicine; Zheng L, Zhang L et. al.

Jan 21st, 2023 - Besides causing severe acute respiratory syndrome (SARS), SARS‑coronavirus 2 (SARS‑CoV‑2) also harms the digestive system. Given the appearance of numerous cases of SARS‑CoV‑2, it has been demonstrated that SARS‑CoV‑2 is able to harm target organs such as the gastrointestinal tract, liver and pancreas, and either worsen the condition of patients with basic digestive illnesses or make their prog...

Pathogen reduction of monkeypox virus in plasma and whole blood using riboflavin and UV...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857991
PloS One; Ragan IK, Hartson LM et. al.

Jan 21st, 2023 - Monkeypox virus has recently emerged from endemic foci in Africa and, since October 20, 2022, more than 73,000 human infections have been reported by the CDC from over 100 countries that historically have not reported monkeypox cases. The detection of virus in skin lesions, blood, semen, and saliva of infected patients with monkeypox infections raises the potential for disease transmission via ...

SARS-CoV-2-free residual proteins mediated phenotypic and metabolic changes in peripher...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851515
PloS One; Mohammad MG, Ashmawy NS et. al.

Jan 20th, 2023 - The large-scale dissemination of coronavirus disease-2019 (COVID-19) and its serious complications have pledged the scientific research communities to uncover the pathogenesis mechanisms of its etiologic agent, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Methods of unveiling such mechanisms are rooted in understanding the viral agent's interactions with the immune system, incl...

Mucosal Gene Expression in Response to SARS-CoV-2 Is Associated with Viral Load.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973040
Journal of Virology; Rajagopala SV, Strickland BA et. al.

Jan 20th, 2023 - Little is known about the relationships between symptomatic early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load and upper airway mucosal gene expression and immune response. To examine the association of symptomatic SARS-CoV-2 early viral load with upper airway mucosal gene expression, we profiled the host mucosal transcriptome from nasopharyngeal swab samples from 68 ...

Evaluation of pregnancy outcomes in mothers with COVID-19 infection: a systematic revie...
https://doi.org/10.1080/01443615.2022.2162867
Journal of Obstetrics and Gynaecology : the Journal of Th... Simbar M, Nazarpour S et. al.

Jan 19th, 2023 - Pregnant women are one of the endangered groups who need special attention in the COVID-19 epidemic. We conducted a systematic review and summarised the studies that reported adverse pregnancy outcomes in pregnant women with COVID-19 infection. A literature search was performed in PubMed and Scopus up to 1 September 2022, for retrieving original articles published in the English language assess...