About 59,215 results

Delta reinfection risk low among unvaccinated children
Nature Ledford H.

Jun 29th, 2022 - Children and adolescents who had not been vaccinated against COVID-19 mounted a long-lasting immune response to infection with the Delta variant of the coronavirus SARS-CoV-2, according to a large study of Israeli health records1. The study, which has been published as a preprint on medRxiv, has not yet been peer reviewed.

COVID and smell loss: answers begin to emerge
Nature Marshall M.

Jun 9th, 2022 - Researchers are finally making headway in understanding how the SARS-CoV-2 coronavirus causes loss of smell. And a multitude of potential treatments to tackle the condition are undergoing clinical trials, including steroids and blood plasma.

Ambient air pollution and COVID-19 risk: Evidence from 35 observational studies
Environmental Research; Zang ST, .

Mar 30th, 2022 - Coronavirus disease 2019 (COVID-19) is induced by a previously undiscovered coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Lu et al., 2020). Since SARS-CoV-2 was first discovered in December 2019, as of April 25, 2021, more than four million fatalities have been attributed to COVID-19, accounting for approximately 2% of the infected cases (>214 million)...

Genomic surveillance of SARS-CoV-2 in patients presenting neurological manifestations.
PloS One; Vicco A, Caccuri F et. al.

Jul 1st, 2022 - During the first wave of infections, neurological symptoms in Coronavirus Disease 2019 (COVID-19) patients raised particular concern, suggesting that, in a subset of patients, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could invade and damage cells of the central nervous system (CNS). Indeed, up to date several in vitro and in vivo studies have shown the ability of SARS-Co...

Projecting the SARS-CoV-2 transition from pandemicity to endemicity: Epidemiological an...
PLoS Pathogens; Cohen LE, Spiro DJ et. al.

Jul 1st, 2022 - In this review, we discuss the epidemiological dynamics of different viral infections to project how the transition from a pandemic to endemic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) might take shape. Drawing from theories of disease invasion and transmission dynamics, waning immunity in the face of viral evolution and antigenic drift, and empirical data from influenza, den...

Identification of repurposing therapeutics toward SARS-CoV-2 main protease by virtual s...
PloS One; Sanachai K, Somboon T et. al.

Jul 1st, 2022 - SARS-CoV-2 causes the current global pandemic coronavirus disease 2019. Widely-available effective drugs could be a critical factor in halting the pandemic. The main protease (3CLpro) plays a vital role in viral replication; therefore, it is of great interest to find inhibitors for this enzyme. We applied the combination of virtual screening based on molecular docking derived from the crystal s...

Warm Cupping of the Posterior Thorax in Combination with Standard Conventional Therapy ...
Journal of Acupuncture and Meridian Studies; Karimi M, Kazemi AH et. al.

Jul 1st, 2022 - Acute respiratory distress syndrome (ARDS) is commonly found in critically ill patients with coronavirus disease 2019 (COVID-19). As a non-pharmacological treatment of complementary and alternative medicine (CAM), cupping has been clinically used for respiratory symptoms. We sequentially identified a series of patients with COVID-19 with ARDS who were admitted to the intensive care unit (ICU). ...

The nervous system during COVID-19: Caught in the crossfire.
Immunological Reviews; Natale NR, Lukens JR et. al.

Jul 1st, 2022 - SARS-CoV-2, the virus that causes coronavirus disease (COVID)-19, has become a persistent global health threat. Individuals who are symptomatic for COVID-19 frequently exhibit respiratory illness, which is often accompanied by neurological symptoms of anosmia and fatigue. Mounting clinical data also indicate that many COVID-19 patients display long-term neurological disorders postinfection such...

SARS-CoV-2 Antibody Longitudinal Profile of Immune Globulin Preparations.
Military Medicine; Park HJ, Alcover KC et. al.

Jul 1st, 2022 - Intravenous immunoglobulin (IVIG) preparations, used for the treatment of antibody deficiencies, provide a glimpse of the general population's antibody profile as each preparation is generated from a pool of thousands of donors. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the coronavirus disease 2019 (Covid-19) pandemic, and a vaccine for the pr...

Coronavirus (COVID-19) Update: FDA Recommends Inclusion of Omicron BA.4/5 Component for COVID-19 Vaccine Booster Doses | FDA

Jun 30th, 2022 - For Immediate Release: June 30, 2022 Statement From: Peter Marks, M.D., PhD. Director - Center for Biologics Evaluation and Research (CBER) On Tuesday, the U.S. Food and Drug Administration’s independent experts on the Vaccines and Related Biological Products Advisory Committee met to publicly discuss whether a change to the current vaccine strain composition of COVID-19 vaccines for booster do...

Vaccines for New COVID Variants Might Come Too Late

Jun 30th, 2022 - Not surprisingly for an RNA virus, SARS-CoV-2 is proving its propensity for mutation. In swabs from infected patients, the proportion of the Omicron subvariant BA.4 is 2.1% (calendar week 21) compared with 1.2% in the previous week. In the same period of time, the frequency of subvariant BA.5 jumped up to 10.0%compared with 5.0% in the previous week. This dynamic leads to a crucial question: Wh...

South Korea Approves First Domestically Developed COVID Vaccine

Jun 30th, 2022 - SEOUL (Reuters) - South Korea approved its first domestically developed COVID-19 vaccine, manufactured by SK bioscience Co Ltd, for general public use following positive clinical data, authorities said on Wednesday. The SKYCovione vaccine was authorised for a two-dose regimen on people aged 18 or older, with shots given four weeks apart, according to the Ministry of Food and Drug Safety. In a p...

Severe COVID-19 in Chronic Liver Disease Linked With Cholestasis and Secondary Sclerosing Cholangitis

Jun 30th, 2022 - NEW YORK (Reuters Health) - Severe COVID-19 increases the risk for cholestasis and secondary sclerosing cholangitis (SSC) in patients with chronic liver disease (CLD), researchers say. Among 65 patients with preexisting CLD who were hospitalized for COVID-19, 23% developed cholestatic liver failure (cholestasis plus bilirubin at least 6mg/dL) and 15.4% developed SSC on the basis of cross-sectio...

Pfizer Plans a Vaccine to Target All Coronaviruses

Jun 30th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Ask the sibling of any celebrity and they'll tell you they don't get anywhere near the same attention. The same is true for coronaviruses – the one that causes COVID-19 has been in the spotlight for more than 2 years now, while the others at the moment circulate in relative obscurity. With the k...

Dementia prevalence, a contextual factor associated with SARS-CoV-2 in veterans affairs...
Journal of the American Geriatrics Society; Bayer TA, DeVone F et. al.

Jun 30th, 2022 - Alzheimer's disease and related dementias (ADRD) impact the diagnosis and infection control of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in nursing homes (NH) by influencing the behavior of residents and their caregivers. Health system data show an association between ADRD and SARS-CoV-2. Whether this association is present in NH populations remains unknown. How increased SAR...

Early spontaneous breathing for acute respiratory distress syndrome in individuals with...
The Cochrane Database of Systematic Reviews; Hohmann F, Wedekind L et. al.

Jun 30th, 2022 - Acute respiratory distress syndrome (ARDS) represents the most severe course of COVID-19 (caused by the SARS-CoV-2 virus), usually resulting in a prolonged stay in an intensive care unit (ICU) and high mortality rates. Despite the fact that most affected individuals need invasive mechanical ventilation (IMV), evidence on specific ventilation strategies for ARDS caused by COVID-19 is scarce. Spo...

BNT162b2 Vaccine Effectiveness against Omicron in Children 5 to 11 Years of Age.
The New England Journal of Medicine; Cohen-Stavi CJ, Magen O et. al.

Jun 30th, 2022 - Limited evidence is available on the real-world effectiveness of the BNT162b2 vaccine against coronavirus disease 2019 (Covid-19) and specifically against infection with the omicron variant among children 5 to 11 years of age. Using data from the largest health care organization in Israel, we identified a cohort of children 5 to 11 years of age who were vaccinated on or after November 23, 2021,...

Data-Driven Commentary on SARS-CoV-2 Infection, Vaccination, and Fertility.
American Journal of Epidemiology; Klipstein S, Dionne JA et. al.

Jun 30th, 2022 - A recent study by Wesselink et al. (Am J Epidemiol. 2022;191(XX):XXXX-XXXX) adds to the growing body of research finding that vaccination for coronavirus disease 2019 (COVID-19) is safe for individuals either seeking pregnancy or who are pregnant. The study's authors found no effect of COVID-19 vaccination on fecundity in a population of individuals with no known infertility who were attempting...

SARS-CoV-2 and Guillain-Barré Syndrome: Lessons from Viral Infections.
Viral Immunology; Meidaninikjeh S, Sabouni N et. al.

Jun 30th, 2022 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. COVID-19 has a broad clinical spectrum from asymptomatic patients to multiorgan dysfunction and septic shock. Most of the common symptoms of COVID-19 are classified as respiratory disorders, but some reports show neurological involvements. During the COVID-19 pandemic, a case series of neurolo...

Trends in Telehealth Antibiotic Prescribing for Children Through the COVID-19 Pandemic.
Pediatrics Payvandi L, Correa ET et. al.

Jun 30th, 2022 - Telehealth visits increased significantly during the coronavirus disease 2019 (COVID-19) pandemic without consensus on the appropriate scope of telehealth antibiotic prescribing within pediatric primary care. We describe telehealth antibiotic prescribing patterns within our statewide pediatric primary care network during the COVID-19 pandemic. In a retrospective observational study of a large s...