×
About 2,360,348 results

VIDEO: Differentiating glaucoma from nonglaucomatous neuro-ophthalmic disease
https://www.healio.com/news/ophthalmology/20220218/video-differentiating-glaucoma-from-nonglaucomatous-neuroophthalmic-disease

Feb 20th, 2022 - WAIKOLOA, Hawaii — In this Healio Video Perspective from Hawaiian Eye 2022, Andrew G. Lee, MD, discusses ways to differentiate between glaucoma and nonglaucomatous neuro-ophthalmic disease.

VIDEO: Early keratoconus detection key for corneal cross-linking success
https://www.healio.com/news/ophthalmology/20220218/video-early-keratoconus-detection-key-for-corneal-crosslinking-success

Feb 19th, 2022 - WAIKOLOA, Hawaii — In this Healio Video Perspective from Hawaiian Eye 2022, Ronald R. Krueger, MD, discusses strategies for early detection of keratoconus and the benefits of performing cross-linking at an early stage.

VIDEO: Neuromodulators offer relief for patients with superior limbic keratoconjunctivitis
https://www.healio.com/news/ophthalmology/20220209/video-neuromodulators-offer-relief-for-patients-with-superior-limbic-keratoconjunctivitis

Feb 9th, 2022 - WAIKOLOA, Hawaii — In this Healio Video Perspective from Hawaiian Eye 2022, Laura M. Periman, MD, discusses superior limbic keratoconjunctivitis and the potential use of neuromodulators to ease patients’ symptoms.

Proficiency, flexibility help match patients with appropriate MIGS device
https://www.healio.com/news/ophthalmology/20220207/proficiency-flexibility-help-match-patients-with-appropriate-migs-device

Feb 7th, 2022 - WAIKOLOA, Hawaii — With several good MIGS options, the choice often comes down to matching the procedure with the patient, according to a presentation at Hawaiian Eye 2022. John Berdahl, MD, said devices such as the Hydrus microstent (Ivantis/Alcon) and the iStent (Glaukos) have shown efficacy in reducing IOP and medications in patients with glaucoma. “So, how do you choose?” Berdahl said. “I a...

Lower bevacizumab doses, agents with less systemic exposure may be safer options for ROP
https://www.healio.com/news/ophthalmology/20220203/lower-bevacizumab-doses-agents-with-less-systemic-exposure-may-be-safer-options-for-rop

Feb 3rd, 2022 - WAIKOLOA, Hawaii — Systemic effects of anti-VEGF in retinopathy of prematurity have not been ruled out, so it may be wise to use bevacizumab in lower doses or switch to agents with less systemic exposure, according to one presenter. “The BEAT-ROP study demonstrated a beneficial effect for bevacizumab vs. laser in the treatment of zone I, stage 3+ ROP. But one thing I didn’t like was the complet...

VIDEO: Striving for ‘one and done’ with collagen cross-linking
https://www.healio.com/news/ophthalmology/20220126/video-striving-for-one-and-done-with-collagen-crosslinking

Jan 26th, 2022 - WAIKOLOA, Hawaii — In this Healio Video Perspective from Hawaiian Eye 2022, Kathryn M. Hatch, MD, explains why cornea specialists strive for “one and done” when treating keratoconus and other epithelial defects with collagen cross-linking.

VIDEO: ECP viable as stand-alone procedure, in combination with MIGS
https://www.healio.com/news/ophthalmology/20220125/video-ecp-viable-as-standalone-procedure-in-combination-with-migs

Jan 25th, 2022 - WAIKOLOA, Hawaii — In this Healio Video Perspective from Hawaiian Eye 2022, Michael Greenwood, MD, discusses the benefits of adding endoscopic cyclophotocoagulation to any minimally invasive glaucoma surgery.

Be cautious if considering use of premium IOLs in patients with glaucoma
https://www.healio.com/news/ophthalmology/20220121/be-cautious-if-considering-use-of-premium-iols-in-patients-with-glaucoma

Jan 21st, 2022 - WAIKOLOA, Hawaii — Surgeons need to consider the risks and possible refractive outcomes before implanting a premium IOL in a patient with glaucoma, according to a presentation at Hawaiian Eye 2022. Nathan Radcliffe, MD, said that when a patient with glaucoma who already has a premium IOL experiences a problem, the IOL is rarely the issue. “I never remove the premium IOL because as bad as the gl...

Concomitant disease should be considered when treating progressive glaucoma
https://www.healio.com/news/ophthalmology/20220120/concomitant-disease-should-be-considered-when-treating-progressive-glaucoma

Jan 20th, 2022 - WAIKOLOA, Hawaii — Ophthalmologists should consider co-management of other diseases when treating progressive glaucoma, according to a speaker here. “I think that we need to remind ourselves, even as we rush through clinic, to think about the linkage to common disease that puts the optic nerve at risk,” Jeffrey L. Goldberg, MD, PhD, said at Hawaiian Eye 2022. To aid with co-management, he said,...

Glaucoma treatment should be tailored to individual patients
https://www.healio.com/news/ophthalmology/20220120/glaucoma-treatment-should-be-tailored-to-individual-patients

Jan 20th, 2022 - WAIKOLOA, Hawaii — Clinical research, personal experience, physician skill set, patient factors and goals all influence the decision to perform trabeculectomy or use a tube shunt, a speaker said here at Hawaiian Eye 2022. “Individualize the treatment choice to the patient in front of you,” Brian E. Flowers, MD, said. If the IOP target is low or if the patient is younger or has medication tolera...

Retinal fluorescence imaging helps identify early functional changes
https://www.healio.com/news/ophthalmology/20220119/retinal-fluorescence-imaging-helps-identify-early-functional-changes

Jan 19th, 2022 - WAIKOLOA, Hawaii — Fluorescence imaging can be an important tool for early detection of retinal diseases, according to a presentation at Retina 2022. Rishi P. Singh, MD, said that technologies such as fundus autofluorescence (FAF), fluorescence lifetime imaging ophthalmoscopy (FLIO) and oxidized flavoprotein fluorescence (FPF) provide opportunities to identify cell dysfunction before it occurs....

Advances may ease difficulties of visual field testing
https://www.healio.com/news/ophthalmology/20220119/advances-may-ease-difficulties-of-visual-field-testing

Jan 19th, 2022 - WAIKOLOA, Hawaii — Visual field testing is important for detecting progression in patients with glaucoma, but some may have difficulty with the test process, according to a speaker here. “This is very true for the full threshold patterns, which require 15 minutes per eye,” Monica Ertel, MD, PhD, said at Hawaiian Eye 2022. Ertel discussed developments in visual field strategies, including visual...

Take steps to manage pseudoexfoliation glaucoma in cataract surgery
https://www.healio.com/news/ophthalmology/20220119/take-steps-to-manage-pseudoexfoliation-glaucoma-in-cataract-surgery

Jan 19th, 2022 - WAIKOLOA, Hawaii — Keep the cornea in mind and protect the endothelium when managing pseudoexfoliation glaucoma during cataract surgery, a presenter said here. “Consider femto if at all possible to decrease the ultrasound and combine with angle surgery, but skip the implants to save the cornea,” Malik Y. Kahook, MD, said at Hawaiian Eye 2022. The second key is to target the angle first and earl...

Consensus group provides imaging criteria for assessment of geographic atrophy
https://www.healio.com/news/ophthalmology/20220119/consensus-group-provides-imaging-criteria-for-assessment-of-geographic-atrophy

Jan 19th, 2022 - WAIKOLOA, Hawaii — In a series of published reports, the Classification of Atrophy Meeting group provided consensus-based imaging parameters for multimodal assessment of geographic atrophy. The group also revised the definitions of specific features of geographic atrophy (GA) and identified features that may predict progression to atrophy. “In the first CAM report, we described the imaging moda...

VIDEO: Intracameral bimatoprost implant helps reduce glaucoma medication burden
https://www.healio.com/news/ophthalmology/20220119/video-intracameral-bimatoprost-implant-helps-reduce-glaucoma-medication-burden

Jan 19th, 2022 - WAIKOLOA, Hawaii — At Hawaiian Eye 2022, I. Paul Singh, MD, discusses some of the advantages of the use of Durysta intracameral bimatoprost injection to lower IOP in patients with glaucoma. “What’s interesting about Durysta now, having about a year and a half experience with it is that although it releases bimatoprost for 4 months, the duration of effect in some patients can be 6 months, 9 mont...

Several pathways under investigation for dry AMD treatment
https://www.healio.com/news/ophthalmology/20220118/several-pathways-under-investigation-for-dry-amd-treatment

Jan 18th, 2022 - WAIKOLOA, Hawaii — Several pathways are under investigation for the treatment of dry age-related macular degeneration, according to a presentation at Retina 2022. “The big issue for us researchers is we don’t have a good animal model to test anything,” Peter K. Kaiser, MD, said. “We don’t have preclinical models that inform us if a drug is going to work or not because the animal that we use are...

Chang highlights new trends in antibiotic prophylaxis for endophthalmitis
https://www.healio.com/news/ophthalmology/20220118/chang-highlights-new-trends-in-antibiotic-prophylaxis-for-endophthalmitis

Jan 18th, 2022 - WAIKOLOA, Hawaii — Just past the 15-year anniversary of the cefuroxime ESCRS trial, debate regarding antibiotic prophylaxis for endophthalmitis after cataract surgery continues. “When you have something controversial, it's nice to see what our colleagues are doing,” David F. Chang, MD, said at Hawaiian Eye 2022. To that end, surveys of ASCRS members conducted in 2007, 2014 and 2021 published in...

VIDEO: Special considerations needed for premium IOLs in patients with glaucoma
https://www.healio.com/news/ophthalmology/20220118/video-special-considerations-needed-for-premium-iols-in-patients-with-glaucoma

Jan 18th, 2022 - WAIKOLOA, Hawaii — In this Healio Video Perspective from Hawaiian Eye 2022, John Berdahl, MD, of Vance Thompson Vision in Sioux Falls, South Dakota, spoke about premium and toric IOLs in patients with glaucoma. “I was actually quite surprised in an informal poll of the audience at how many surgeons did premium IOLs,” Berdahl said. “The vast majority of hands went up, but they actually stayed up...

Address ocular surface disease before surgery to optimize patient satisfaction
https://www.healio.com/news/ophthalmology/20220117/address-ocular-surface-disease-before-surgery-to-optimize-patient-satisfaction

Jan 17th, 2022 - WAIKOLOA, Hawaii — Diagnosing and treating ocular surface disease preoperatively is one of the elements that contribute to elevated patient satisfaction postoperatively, Marjan Farid, MD, said at Hawaiian Eye 2022. “We know that 50% of patients, at least, who come in for cataract surgery are asymptomatic, but at least 80% of those patients have at least one sign of dry eye disease,” Farid said ...

Ocular oncology landscape ‘rapidly evolving’
https://www.healio.com/news/ophthalmology/20220117/ocular-oncology-landscape-rapidly-evolving

Jan 17th, 2022 - WAIKOLOA, Hawaii — The landscape of ocular oncology is “rapidly evolving” in a way similar to medical oncology, a speaker said during a presentation here. At Hawaiian Eye 2022, Basil K. Williams Jr., MD, discussed how anterior segment OCT can be a “valid help adjunct” to clinical exams, although it is not a replacement for them. OCT can also help physicians differentiate between different lesio...

Medicare cuts, ASC rates, new FDA-approved drugs: Latest for 2022
https://www.healio.com/news/ophthalmology/20220117/medicare-cuts-asc-rates-new-fdaapproved-drugs-latest-for-2022

Jan 17th, 2022 - WAIKOLOA, Hawaii — Medicare payment changes, ASC payment rates and new FDA approved drugs were a few of the topics discussed in a presentation on 2022 updates for ophthalmic practices at Hawaiian Eye 2022. Paul M. Larson, MBA, MMSC, COMT, CPC, COE, CPMA, a senior consultant from Corcoran Consulting Group, said that the Medicare Physician Fee Schedule was just updated a few weeks ago. “With the ...

How to avoid the perils of uveitis diagnostic management
https://www.healio.com/news/ophthalmology/20220116/how-to-avoid-the-perils-of-uveitis-diagnostic-management

Jan 16th, 2022 - WAIKOLOA, Hawaii — It is important for physicians to consider “the perils that dwell” in the diagnostic management of patients with uveitis, Steven Yeh, MD, said during a presentation at Hawaiian Eye 2022. “With these patients being very complex oftentimes, we really just don’t want to miss something,” Yeh said. To better identify “the pearls amongst the perils” in uveitis diagnosis, it is impo...

VIDEO: Dextenza helps reduce post-cataract surgery glaucoma drop burden
https://www.healio.com/news/ophthalmology/20210524/video-dextenza-helps-reduce-postcataract-surgery-glaucoma-drop-burden

May 24th, 2021 - WAILEA, Hawaii — In this Hawaiian Eye 2021 video, Savak “Sev” Teymoorian, MD, MBA, explains how Dextenza (dexamethasone, Ocular Therapeutix) intracanalicular inserts can reduce drop burden in patients with glaucoma after cataract surgery.

VIDEO: Lee explains how to identify NMOSD in patients with optic neuritis
https://www.healio.com/news/ophthalmology/20210521/video-lee-explains-how-to-identify-nmosd-in-patients-with-optic-neuritis

May 21st, 2021 - WAILEA, Hawaii — In this video from Hawaiian Eye 2021, Andrew G. Lee, MD, discusses the important questions ophthalmologists should ask patients with optic neuritis to identify neuromyelitis optica spectrum disorder.

VIDEO: Durysta helps patients overcome challenge of instilling glaucoma drops
https://www.healio.com/news/ophthalmology/20210521/video-durysta-helps-patients-overcome-challenge-of-instilling-glaucoma-drops

May 21st, 2021 - WAILEA, Hawaii — In this video at Hawaiian Eye 2021, Savak Teymoorian, MD, MBA, discusses how the Durysta bimatoprost implant 10 µg from Allergan obviates the need for patients with glaucoma to instill drops.

Home OCT with AI may be feasible for patients with wet AMD
https://www.healio.com/news/ophthalmology/20210518/holekamp-nm-home-oct-for-monitoring-namd-presented-at-retina-2021-may-814-2021-wailea-hawaii

May 18th, 2021 - WAILEA, Hawaii — The COVID-19 pandemic changed the way physicians monitor age-related macular degeneration, and Nancy M. Holekamp, MD, believes those changes are here to stay. “We all learned that remote monitoring of our patients is desirable, even if there isn’t a pandemic,” she said in her presentation at Retina 2021. “It currently exists with monitoring patients with intermediate AMD, and t...

Aqueous humor holds potential as surrogate biopsy of retinoblastoma
https://www.healio.com/news/ophthalmology/20210514/aqueous-humor-holds-potential-as-surrogate-biopsy-of-retinoblastoma

May 14th, 2021 - WAILEA, Hawaii — New research using liquid biopsy presents a new opportunity for treating retinoblastoma. Currently, retinoblastoma is diagnosed clinically, without biopsy, to avoid extraocular tumor seeding. In ongoing research, Jesse L. Berry, MD, of USC Roski Eye Institute, and colleagues are finding potential for using aqueous humor, obtained safely, as a means of diagnosing retinoblastoma,...

VIDEO: Innovative technology reframes ‘controlled’ glaucoma
https://www.healio.com/news/ophthalmology/20210514/video-innovative-technology-reframes-controlled-glaucoma

May 14th, 2021 - WAILEA, Hawaii — In this video from Hawaiian Eye, I. Paul Singh, MD, discusses how innovative technology has changed his definition of controlled glaucoma.

Weigh pros, cons of at-home IOP measurements
https://www.healio.com/news/ophthalmology/20210513/weigh-pros-cons-of-athome-iop-measurements

May 13th, 2021 - WAILEA, Hawaii — Glaucoma patients may ask for ways to monitor IOP between visits, but ophthalmologists should weigh benefits and drawbacks of at-home monitoring options, according to speakers at Hawaiian Eye 2021. “I have that question all the time, actually,” Sahar Bedrood, MD, PhD, said. “Some of my patients are significantly worried, so they come in.” Options for at-home eye care include re...

Shields receives Philip M. Corboy, MD, award
https://www.healio.com/news/ophthalmology/20210513/shields-receives-phillip-m-corboy-md-award

May 13th, 2021 - WAILEA, Hawaii — M. Bruce Shields, MD, was awarded the Philip M. Corboy, MD, Memorial Award for Distinguished Service to Ophthalmology at Hawaiian Eye 2021. Shields was unable to attend the meeting but accepted the award by way of a recorded video. “I sure wish we could be with you, but I’m grateful to the organizing committee of the Hawaiian Eye meeting that we can at least join you virtually,...

VIDEO: Bedrood discusses experience with iStent inject
https://www.healio.com/news/ophthalmology/20210512/video-bedrood-discusses-experience-with-istent-inject

May 12th, 2021 - WAILEA, Hawaii — In this video from Hawaiian Eye 2021, Sahar Bedrood, MD, PhD, discusses how she has incorporated the iStent inject (Glaukos) into her practice, patient selection and the benefits of using the device in those with glaucoma.

VIDEO: Samuelson discusses best practices in combined glaucoma, cataract cases
https://www.healio.com/news/ophthalmology/20210512/video-samuelson-discusses-best-practices-in-combined-glaucoma-cataract-cases

May 12th, 2021 - WAILEA, Hawaii — In this video from Hawaiian Eye, Thomas W. Samuelson, MD, discusses the nuanced decision-making that goes into deciding which surgical interventions to use in patients with glaucoma who are also in need of cataract surgery.

VIDEO: Reasons to crosslink patients with keratoconus before cataract surgery
https://www.healio.com/news/ophthalmology/20210511/video-reasons-to-crosslink-patients-with-keratoconus-before-cataract-surgery

May 11th, 2021 - WAILEA, Hawaii — In this video from Hawaiian Eye, Brandon D. Ayres, MD, discusses why patients with keratoconus and cataract should receive corneal collagen crosslinking prior to cataract surgery.

VIDEO: Steps to take to implement MIGS into an ophthalmology practice
https://www.healio.com/news/ophthalmology/20210510/video-steps-to-take-to-implement-migs-into-an-ophthalmology-practice

May 10th, 2021 - WAILEA, Hawaii — At Hawaiian Eye 2021, Deborah G. Ristvedt, DO, discusses how to implement minimally invasive glaucoma surgery techniques in a surgical practice using the newest technologies.

Natural History and Development of Spondyloarthritis
https://clinicaltrials.gov/ct2/show/NCT01422694

Jan 13th, 2023 - The purpose of this protocol is to study the natural history of spondyloarthritis (SpA) in children and adults. Spondyloarthritis encompasses a spectrum of immune-mediated inflammatory diseases that exhibit overlapping features, but differ from other types of inflammatory arthritis in genetic predisposition, pathogenesis, and outcome. Ankylosing spondylitis (AS), the most common form of SpA, fr...

RECOVER Researchers Express Hope and Frustration in Their Study of Long COVID
https://www.medpagetoday.com/special-reports/exclusives/99403
MedPage Today; DePeau-Wilson M.

Jul 23rd, 2022 - Slow enrollment has led to simmering frustrations over the progress and potential of the NIH's RECOVER Initiative, the research consortium focused on studying post-acute sequelae of SARS-CoV-2, or long COVID, according to researchers and leaders within the initiative. The RECOVER Initiative was designed to support research on long COVID across the U.S., including among every group of people ...

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
https://doi.org/10.1002/art.41752
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

2019 Update of the American College of Rheumatology/Spondylitis Association of America/...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764882
Arthritis & Rheumatology (Hoboken, N.J.); Ward MM, Deodhar A et. al.

Aug 23rd, 2019 - To update evidence-based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA). We conducted updated systematic literature reviews for 20 clinical questions on pharmacologic treatment addressed in the 2015 guidelines, and for 26 new questions on pharmacologic treatment, treat-to-target strategy, and use of imaging. New q...

Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters
https://www.biorxiv.org/content/10.1101/2022.10.24.513619v1
BioRxiv Collier AY, .

Oct 25th, 2022 - Waning immunity following mRNA vaccination and the emergence of SARS-CoV-2 variants has led to reduced mRNA vaccine efficacy against both symptomatic infection and severe disease. Bivalent mRNA boosters expressing the Omicron BA.5 and ancestral WA1/2020 Spike proteins have been developed and approved, because BA.5 is currently the dominant SARS-CoV-2 variant and substantially evades neutralizin...

Antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot
https://www.biorxiv.org/content/10.1101/2022.10.22.513349v1
BioRxiv Wang Q, .

Oct 24th, 2022 - The SARS-CoV-2 Omicron variant and its numerous sub-lineages have exhibited a striking ability to evade humoral immune responses induced by prior vaccination or infection. The Food and Drug Administration (FDA) has recently granted Emergency Use Authorizations (EUAs) to new bivalent formulations of the original Moderna and Pfizer mRNA SARS-CoV-2 vaccines that target both the ancestral strain as...

Evolution of immune genes is associated with the Black Death
https://www.nature.com/articles/s41586-022-05349-x
Nature Klunk, J. et. al.

Oct 19th, 2022 - Infectious diseases are among the strongest selective pressures driving human evolution1,2. This includes the single greatest mortality event in recorded history, the first outbreak of the second pandemic of plague, commonly called the Black Death, which was caused by the bacterium Yersinia pestis3. This pandemic devastated Afro-Eurasia, killing up to 30–50% of the population4. To identify loci...

Black Death shaped evolution of immunity genes, setting course for how we respond to disease today
https://brighterworld.mcmaster.ca/articles/black-death-immunity-genes/
McMaster University; Donovan M.

Oct 19th, 2022 - An international team of scientists who analyzed centuries-old DNA from victims and survivors of the Black Death pandemic has identified key genetic differences that determined who lived and who died, and how those aspects of our immune systems have continued to evolve since that time. Researchers from McMaster University, the University of Chicago, the Pasteur Institute and other organizati...

Prevalence and Factors Associated With Antigen Test Positivity Following SARS-CoV-2 Infection Among Health Care Workers in Los Angeles
https://academic.oup.com/ofid/article/9/10/ofac462/6762879
Open Forum Infectious Diseases; Adamson PC, .

Oct 19th, 2022 - Surges of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among health care workers (HCWs) have led to critical staffing shortages. From January 4 to February 4, 2022, we implemented a return-to-work antigen testing program for HCWs, and 870 HCWs participated. Antigen test positivity was 60.5% for those ≤5 days from symptom onset or positive polymerase chain reaction (PC...

Prevalence of Positive Rapid Antigen Tests After 7-Day Isolation Following SARS-CoV-2 Infection in College Athletes During Omicron Variant Predominance
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2797450
JAMA Network Open; Tsao J, Kussman A et. al.

Oct 18th, 2022 - One of the cornerstones of management during the COVID-19 pandemic has been to isolate individuals with infection to prevent viral spread. Guidelines for most of the pandemic have recommended 10 days of isolation.1 However, this prolonged period of isolation can lead to lost wages, workforce shortages, and other negative socioeconomic factors.

JAK Inhibitor Improves Symptoms, Anemia in Myelofibrosis
https://www.medpagetoday.com/hematologyoncology/othercancers/102883

Jan 30th, 2023 - Myelofibrosis treatment with the Janus kinase (JAK) inhibitor momelotinib resulted in clinically significant improvements in symptoms and spleen response compared with danazol for symptomatic, JAK inhibitor-exposed patients with anemia and intermediate- or high-risk disease, the phase III MOMENTUM trial showed. A significantly greater proportion of patients in the momelotinib group reported a ≥...

Commentary: Early Diagnosis of PsA, February 2023
https://www.mdedge.com/rheumatology/article/260916/psoriatic-arthritis/commentary-early-diagnosis-psa-february-2023
Vinod Chandran, MBBS, MD, DM, PhD

Jan 30th, 2023 - Vinod Chandran, MBBS, MD, DM, PhD Most patients develop psoriatic arthritis (PsA) after the onset of cutaneous psoriasis. The path toward long-term remission of PsA may be by early diagnosis and effective treatment prior to the onset of joint damage.

Acute hepatic porphyrias no longer as rare as previously thought
https://www.mdedge.com/internalmedicine/article/260911/gastroenterology/acute-hepatic-porphyrias-no-longer-rare-previously
Carolyn Crist

Jan 30th, 2023 - Although rare, acute hepatic porphyrias (AHPs) may be more common than previously thought, particularly among women between ages 15 and 50, according to a new clinical practice update from the American Gastroenterological Association. For acute attacks, treatment should include intravenous hemin, and for patients with recurrent attacks, a newly-approved therapy called givosiran should be consid.

Study: Diminished COVID Vaccine Response in Lupus
https://www.medpagetoday.com/rheumatology/lupus/102876

Jan 30th, 2023 - Patients with systemic lupus erythematosus (SLE) showed reduced antibody responses following COVID-19 vaccination, with drugs for the condition such as belimumab (Benlysta) and mycophenolate mofetil (MMF) likely to blame, researchers said. Immunoglobulin G (IgG) titers measured 2 weeks after the second dose of mRNA COVID vaccines were lower by about 20% among 342 lupus patients compared with th...

Reversible BTK Inhibitor Gets FDA Nod for Mantle Cell Lymphoma
https://www.medpagetoday.com/hematologyoncology/lymphoma/102874

Jan 30th, 2023 - The FDA has granted accelerated approval to pirtobrutinib (Jaypirca), a non-covalent or reversible Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of relapsed or refractory mantle cell lymphoma (MCL) after at least two prior lines of systemic therapy, including a BTK inhibitor. Pirtobrutinib is the first BTK inhibitor of any kind specifically approved for patients with MCL that has ...

Viruses Tied to Subsequent Dementia, Other Neurodegenerative Diseases
https://www.medpagetoday.com/neurology/generalneurology/102872

Jan 30th, 2023 - At least 22 viral illnesses were linked with an increased risk of subsequent neurodegenerative disease, NIH researchers found. Using data from the U.K. and Finland, Mike Nalls, PhD, of the NIH Center for Alzheimer's and Related Dementias, and co-authors identified 45 viral exposures that were tied to an increased risk of dementia or other neurodegenerative diseases and replicated 22 of these as...

Use of Straighteners and Other Hair Products and Incident Uterine Cancer
https://academic.oup.com/jnci/advance-article/doi/10.1093/jnci/djac165/6759686
JNCI: Journal of the National Cancer Institute; Chang C, .

Oct 17th, 2022 - Hair products may contain hazardous chemicals with endocrine-disrupting and carcinogenic properties. Previous studies have found hair product use to be associated with a higher risk of hormone-sensitive cancers including breast and ovarian cancer; however, to our knowledge, no previous study has investigated the relationship with uterine cancer.

Woman Seeks Answers After 3 Years of Painful Genital Ulcers
https://www.medpagetoday.com/dermatology/generaldermatology/102873

Jan 30th, 2023 - A woman in her late 40s presented with painful ulcers in her groin and armpits that hadn't healed in 3 years, an Indian group reported in JAMA Dermatology. The woman explained that when the sores first appeared, they were just itchy, oozing, reddish bumps; over time, they worsened to form painful, pus-filled oozing ulcers. She had been treated with numerous courses of antibiotics, antifungals, ...

Perineal leiomyoma after 4th degree laceration
https://www.mdedge.com/obgyn/article/260905/perineal-leiomyoma-after-4th-degree-laceration
Mary K. Collins, DO, G. William Stone, MD et. al.

Jan 29th, 2023 - Additional videos from SGS are available here, including these recent offerings: Tips and tricks for a successful rollerball endometrial ablation Resection of infected sacrohysteropexy mesh Surgical techniques for excision of juvenile cystic adenomyoma.

Synopsis - Infant Botulism, Israel, 2007-2021
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733534

cases indicate a stronger link to soil transmission, possible seasonal variation, and a milder course of disease.

Advanced Ann Arbor stage and age over 60 years as prognostic predictors in patients wit...
https://doi.org/10.1186/s12885-023-10548-4
BMC Cancer; Gao L, Chen X et. al.

Jan 29th, 2023 - To evaluate the overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) for primary cervical lymphoma (PCL), an extremely rare disease without treatment consensus. We conducted a retrospective study included 177 patients, including 169 cases identified from literature review. The Kaplan-Meier methods and Cox regression were used to determine the OS, DSS, RFS, ...

High resolution dermal ultrasound (US) combined with superficial radiation therapy (SRT...
https://doi.org/10.1186/s12885-023-10577-z
BMC Cancer; Yu L, Moloney M et. al.

Jan 29th, 2023 - To compare the effectiveness of high-resolution dermal ultrasound (US) guided superficial radiotherapy (SRT) to non-image-guided radiotherapy in the treatment of early-stage Non-Melanoma Skin Cancer (NMSC). A high-resolution dermal ultrasound (US) image guided form of superficial radiation therapy (designated here as US-SRT) was developed in 2013 where the tumor configuration and depth can be v...

Establishment and evaluation of nomogram for predicting intraventricular hemorrhage in ...
https://doi.org/10.1186/s12887-023-03853-1
BMC Pediatrics; Arkin N, Wang Y et. al.

Jan 29th, 2023 - Intraventricular hemorrhage (IVH) is the most common type of brain injury in newborns, especially in newborns with Neonatal acute respiratory distress syndrome (ARDS). IVH can cause brain parenchyma damage and long-term neurological sequelae in children. Early identification and prevention of sequelae are essential. This study aims to establish a predictive nomogram for the early prediction of ...

Baseline characteristics and treatment response predictive of nAMD outcomes with ranibi...
https://doi.org/10.1186/s12886-023-02780-0
BMC Ophthalmology; Tsai CY, Wu CL et. al.

Jan 29th, 2023 - The Ranibizumab AMD Clinical Efficacy Study (RACER) conducted in treatment-naive adult Taiwanese patients with neovascular age-related macular degeneration (nAMD) suggested the importance of early and intensive dosing of ranibizumab for optimal treatment outcomes. This subgroup analysis aims to provide clinical information on treatment response that can potentially guide on maintaining the trea...

Diagnosis and management of keratoconus by eye care practitioners in Kenya.
https://doi.org/10.1186/s12886-023-02792-w
BMC Ophthalmology; Rashid ZA, Moodley VR et. al.

Jan 29th, 2023 - To explore current eye care practice in keratoconus diagnosis and management in Kenya. An online questionnaire was distributed to ophthalmic clinical officers (OCO) and optometrists. A total of 203 responses were received from 52 OCOs and 151 optometrists with a response rate of 24.4% and 53.5% respectively. The majority reported having access to retinoscopes (88.5%; p = 0.48) and slit lamps (7...

Three nervous system-specific expressed genes are potential biomarkers for the diagnosi...
https://doi.org/10.1186/s12920-023-01441-x
BMC Medical Genomics; Liao Y, Cai H et. al.

Jan 29th, 2023 - Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease in adults. However, ALS, especially sporadic ALS (sALS), is difficult to diagnose due to the lack of biomarkers. We used the bioinformatics technology to find the potential biomarker and we found that two hundred seventy-four DEGs were identified and enrichment analysis showed DEGs were involved in nervous system a...

Vibrio vulnificus sepsis after shrimp shelling in a patient with preexisting primary bi...
https://doi.org/10.1186/s13256-023-03767-7
Journal of Medical Case Reports; Sakihara E, Noge I et. al.

Jan 29th, 2023 - Vibrio vulnificus is typically present in seawater, fish, and shellfish, and is known to cause severe sepsis, particularly in patients with liver diseases such as cirrhosis. V. vulnificus is one of the most dangerous waterborne pathogens, and infection mainly occurs in western Japan during the summer, with an increased fatality rate. Herein, we report the case of a patient with primary biliary ...

The prognostic value and immune correlation of IL18 expression and promoter methylation...
https://doi.org/10.1186/s13148-023-01426-8
Clinical Epigenetics; Wang X, Zhu W et. al.

Jan 29th, 2023 - Renal cell carcinoma (RCC) is not sensitive to immunotherapy and has poor prognosis. DNA methylation regulates gene expression, and its abnormal changes are related to many human diseases. Recently, DNA methylation has been found to participate in immune infiltration in various cancers. However, its pattern in RCC remains poorly understood. We found that IL18 was significantly over-expressed in...

Multi-country evaluation of the durability of pyrethroid plus piperonyl-butoxide insect...
https://doi.org/10.1186/s12936-023-04465-x
Malaria Journal; Mbuba E, Odufuwa OG et. al.

Jan 29th, 2023 - Mass distributions of long-lasting insecticidal nets (LLINs) have contributed to large reductions in the malaria burden. However, this success is in jeopardy due in part to the increasing pyrethroid-resistant mosquito population as well as low LLINs coverage in various areas because the lifespan of LLINs is often shorter than the interval between replenishment campaigns. New insecticide-treated...

Childhood-onset primary Sjögren's syndrome in a tertiary center in China: clinical feat...
https://doi.org/10.1186/s12969-022-00779-3
Pediatric Rheumatology Online Journal; Gong Y, Liu H et. al.

Jan 29th, 2023 - To characterize the clinical features and outcomes of childhood-onset primary Sjögren's syndrome (pSS). Patients less than 18 years old who were diagnosed with pSS by paediatric rheumatologists were included, and all patients were applied the 2002 American-European Consensus Group (ACEG) criteria, the 2016 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria ...

Exaggerated levels of some specific TLRs, cytokines and chemokines in Japanese encephal...
https://doi.org/10.1186/s12985-023-01966-8
Virology Journal; Shukla M, Garg A et. al.

Jan 29th, 2023 - Japanese encephalitis (JE) disease, a viral brain fever is caused by Japanese encephalitis virus (JEV). Despite the availability of effective vaccines against this deadly infection, JE is the leading cause of epidemic viral encephalitis in children in South-east Asia. There is no treatment available for the JE disease which might be due to incomplete understanding of the pathogenesis of JE viru...

Identification and validation of pyroptosis-related gene landscape in prognosis and imm...
https://doi.org/10.1186/s13048-022-01065-2
Journal of Ovarian Research; Gao L, Ying F et. al.

Jan 29th, 2023 - Emerging evidence has highlighted the biological significance of pyroptosis in tumor tumorigenesis and progression. Nonetheless, the potential roles of pyroptosis in tumor immune microenvironment and target therapy of ovarian cancer (OC) remain unknown. In this study, with a series of bioinformatic and machine learning approaches, we comprehensively evaluated genetic alterations and transcripto...

The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway i...
https://doi.org/10.1186/s12967-023-03895-0
Journal of Translational Medicine; Shen X, Zhi F et. al.

Jan 29th, 2023 - Arsenic trioxide (ATO) is the first-line therapeutic drug for acute promyelocytic leukemia. However, the cardiotoxicity of ATO limits its clinical application. This study aims to explore the long noncoding RNA (lncRNA) involved molecular mechanism in ATO-induced cardiotoxicity and to identify available prevention strategies. ATO was administered to mice or primary cultured mouse cardiomyocytes....

Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upr...
https://doi.org/10.1186/s13024-023-00597-5
Molecular Neurodegeneration; Kisler K, Sagare AP et. al.

Jan 29th, 2023 - PICALM is one of the most significant susceptibility factors for Alzheimer's disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium. PICALM endothelial levels are reduced in AD brains. PICALM controls several steps in Aβ transcytosis across the blood-brain barrier (BBB). Its loss from brain endothelium in mice diminishes Aβ clearance at the BBB, which worsens Aβ patho...

Integrated investigation of the clinical implications and targeted landscape for RNA me...
https://doi.org/10.1186/s40001-023-01016-7
European Journal of Medical Research; Zhang J, Gao J et. al.

Jan 29th, 2023 - RNA methylation (RM) is a crucial post-translational modification (PTM) that directs epigenetic regulation. It mostly consists of N1-methyladenosine (m1A), 5-methylcytosine (m5C), N3-methylcytidine (m3C), N6-methyladenosine (m6A), and 2'-O-methylation (Nm). The "writers" mainly act as intermediaries between these modifications and associated biological processes. However, little is known about ...

TRMT6 promotes hepatocellular carcinoma progression through the PI3K/AKT signaling path...
https://doi.org/10.1186/s40001-022-00951-1
European Journal of Medical Research; Ye Y, Liu M et. al.

Jan 29th, 2023 - Hepatocellular carcinoma is one of the most common and deadly cancers. The aim of this study was to elucidate the role of tRNA methyltransferase 6 (TRMT6) during HCC progression. The role of TRMT6 in the progression and prognosis of HCC was confirmed by analysis of online databases and clinical human samples. The effects of up-regulation or down-regulation of TRMT6 on HCC cell proliferation and...

Mitigation of therapeutic anti-CD38 antibody interference with fab fragments: How well ...
https://doi.org/10.1111/trf.17253
Transfusion Habicht CP, Ridders M et. al.

Jan 29th, 2023 - Administration of anti-CD38 antibodies is a state-of-the-art therapy for patients diagnosed with multiple myeloma (MM). However, this treatment frequently leads to pan-agglutination of red blood cells (RBCs) in patients' serological testing making accurate blood typing and timely transfusion of compatible blood a challenging effort. The antigen masking indirect antiglobulin test (AMIAT) is an a...

The pattern of MHC class I expression in muscle biopsies from patients with myositis an...
https://doi.org/10.1093/rheumatology/kead052
Rheumatology (Oxford, England); Milisenda JC, Pinal-Fernandez I et. al.

Jan 29th, 2023 - Diagnostic muscle biopsies are routinely immunostained for major histocompatibility complex class I (MHC-I) protein. In this study, we analyzed the prevalence and patterns of MHC-I immunostaining in biopsies from patients with different types of myopathies and neurogenic disorders. All 357 diagnostic muscle biopsies processed at the Johns Hopkins Neuromuscular Pathology Laboratory from August 2...

Seroprevalence of SARS-CoV2 Infections in Health Care Personnel in a Long-Term Care Ins...
https://doi.org/10.1177/21650799221135587
Workplace Health & Safety; Bautista Balbás LA, Sandino Gómez R et. al.

Jan 29th, 2023 - At the time of our study, occupational health evidence specific for long-term care employees was mostly lacking. The purpose of this study was to determine the proportion of positive cases in employees after the first COVID-19 wave in May 2020. We also determined the prevalence of asymptomatic cases. The study population included all health care workers (HCW) employed at one mid-size long-term ...

Failure to detect SARS-CoV-2 at RNA and protein level in the sweat of patients with COV...
https://doi.org/10.1093/bjd/ljac123
The British Journal of Dermatology; Gambichler T, Goesmann S et. al.

Jan 29th, 2023 - Failure to detect SARS-CoV-2 at RNA and protein level in the sweat of patients with COVID-19.|2023|Gambichler T,Goesmann S,Korte V,Skrygan M,Harnischfeger F,|

Extracellular vesicles: a comprehensive review of their roles as biomarkers and potenti...
https://doi.org/10.1093/ced/llac108
Clinical and Experimental Dermatology; Born LJ, Khachemoune A

Jan 29th, 2023 - Psoriasis is a chronic immune-mediated condition that affects the skin and joints, with current treatments still unable to offer a cure and long-term use of treatments posing health risks. Understanding the pathogenesis of the disease has helped identify new targets that have allowed for the expansion of the therapeutic arsenal. Extracellular vesicles (EVs) have recently emerged as pathophysiol...

Infections in travellers returning to the UK: a retrospective analysis (2015-2020).
https://doi.org/10.1093/jtm/taad003
Journal of Travel Medicine; Warner JC, Hatziioanou D et. al.

Jan 29th, 2023 - Every year, many thousands of travellers return to the United Kingdom (UK) from visits to other countries and some will become unwell due to infections acquired abroad. Many imported infections have similar clinical presentations, such as fever and myalgia, so diagnostic testing is an important tool to improve patient management and outcomes. The aim of this study was to examine the demographic...

L1CAM promotes vasculogenic mimicry formation by miR-143-3p-induced expression of hexok...
https://doi.org/10.1002/1878-0261.13384
Molecular Oncology; Huang Y, Zhu C et. al.

Jan 29th, 2023 - In recent decades, antiangiogenic therapy, which blocks the supply of oxygen and nutrition to tumor cells, has become a promising clinical strategy for the treatment of patients with tumors. However, recent studies revealed that vasculogenic mimicry (VM), which is the process by which vascular morphological structures are formed by highly invasive tumor cells, has been considered a potential fa...

Pediatric neurobrucellosis: a systematic review with case report.
https://doi.org/10.1093/tropej/fmad004
Journal of Tropical Pediatrics; Dhar D, Jaipuriar RS et. al.

Jan 29th, 2023 - Pediatric neurobrucellosis represents a common anthropozoonosis in endemic areas but only anecdotal reports are available till date. Using appropriate search terms in the database platforms of MEDLINE, SCOPUS and Web of Sciences, we performed a systematic review of all the cases of pediatric neurobrucellosis published in the medical literature till date, in the light of a case report. The proto...

The effects of altered DNA damage repair genes on mutational processes and immune cell ...
https://doi.org/10.1002/cam4.5663
Cancer Medicine; Yuan H, Qing T et. al.

Jan 29th, 2023 - Defects in DNA damage repair (DDR) pathways lead to genomic instability and oncogenesis. DDR deficiency is prevalent in esophageal squamous cell carcinoma (ESCC), but the effects of DDR alterations on mutational processes and tumor immune microenvironment in ECSS remain unclear. Whole-exome and transcriptome sequencing data of 45 ESCC samples from Taizhou, China, were used to identify genomic v...

Identification of EMP1 as a critical gene for cisplatin resistance in ovarian cancer by...
https://doi.org/10.1002/cam4.5637
Cancer Medicine; Zeng Q, Yi C et. al.

Jan 29th, 2023 - Cisplatin resistance is among the main reasons for the poor prognosis of ovarian cancer (OC) patients. Until now, effective biomarkers for predicting cisplatin resistance in OC and specific drugs for reversing this resistance are lacking. This study identified the critical gene associated with cisplatin resistance in OC and provided a potential target for overcoming this resistance. Differentia...

High expression of LOC541471, GDAP1, SOD1, and STK25 is associated with poor overall su...
https://doi.org/10.1002/cam4.5644
Cancer Medicine; Yu X, Chen C et. al.

Jan 29th, 2023 - Acute myeloid leukemia (AML) is an aggressive heterogeneous hematological malignancy with remarkably heterogeneous outcomes. This study aimed to identify potential biomarkers for AML risk stratification via analysis of gene expression profiles. RNA sequencing data from 167 adult AML patients in the Cancer Genome Atlas (TCGA) database were obtained for overall survival (OS) analysis, and 52 bone...

Quantitative systems pharmacology of the eye: Tools and data for ocular QSP.
https://doi.org/10.1002/psp4.12918
CPT: Pharmacometrics & Systems Pharmacology; Kuepfer L, Fuellen G et. al.

Jan 29th, 2023 - Good eyesight belongs to the most-valued attributes of health, and diseases of the eye are a significant healthcare burden. Case numbers are expected to further increase in the next decades due to an aging society. The development of drugs in ophthalmology, however, is difficult due to limited accessibility of the eye, in terms of drug administration and in terms of sampling of tissues for drug...

Assessment of the efficacy and tolerability of ruxolitinib for the treatment of myelofi...
https://doi.org/10.1002/cam4.5618
Cancer Medicine; Coltro G, Sant'Antonio E et. al.

Jan 29th, 2023 - Incorporating real-world data in the drug development process allows the improvement of health outcomes by providing better representation of actual patterns of drug safety and efficacy. Here, we present the results of a retroprospective, observational real-life study of 154 patients with myelofibrosis treated with ruxolitinib in a real-life setting in seven Italian centers of the MYNERVA proje...

Preclinical pharmacokinetics and tolerability of a novel meglumine-based parenteral sol...
https://doi.org/10.1111/epi.17520
Epilepsia Rundfeldt C, Klein P et. al.

Jan 29th, 2023 - For an anti-seizure medication (ASM) to be effective in status epilepticus (SE), the drug should be administered intravenously (i.v.) to provide quick access to the brain. However, poor aqueous solubility is a major problem in the development of parenteral drug solutions. Given its multiple mechanisms of action, topiramate (TPM) is a promising candidate for the treatment of established or refra...

Clinical characteristics and serum CA19-9 combined with HE4 are valuable in diagnosing ...
https://doi.org/10.1002/ijgo.14695
International Journal of Gynaecology and Obstetrics: the ... Xu T, Zhang L et. al.

Jan 29th, 2023 - Endometriosis associated ovarian cancer (EAOC) is difficult to diagnose as low incidence, uncertain risk factors, and absence of effective markers. This study aimed to investigate clinical characteristics of EAOC and identify useful serological markers. We retrospectively studied clinical characteristics of 220 patients, of which 44 with EAOC and 176 with ovarian endometriosis (OEM), obtained f...

Transmission of Mpox: A narrative review of environmental, viral, host and population f...
https://doi.org/10.1002/jmv.28534
Journal of Medical Virology; Pan D, Nazareth J et. al.

Jan 29th, 2023 - Monkeypox virus (mpox) has spread globally. Emerging studies have now provided evidence regarding mpox transmission, that can inform rational evidence-based polices and reduce misinformation on this topic. We aimed to review the evidence on transmission of the virus. Real-world studies have isolated viable virus from high touch surfaces for as long as 15 days. Strong evidence suggests that curr...

Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole-thy...
https://doi.org/10.1080/10717544.2023.2173337
Drug Delivery; Sindi AM, Rizg WY et. al.

Jan 29th, 2023 - The use of essential oil-based nanoemulsions (NEs) has been the subject of extensive research on a variety of conditions affecting the oral cavity. NEs are delivery methods that improve the solubility and distribution of lipid medicines to the intended areas. Because of their antibacterial and antifungal properties, itraconazole and thyme oil-based self-nanoemulsifying drug delivery systems (It...

Patient characteristics and factors contributing to recurrence of bacterial vaginosis p...
https://doi.org/10.1093/fampra/cmad005
Family Practice; Delfstra NS, Uijen AA et. al.

Jan 29th, 2023 - Bacterial vaginosis (BV) is a common problem in primary care. BV symptoms often have a negative impact on patients' quality of life and may predispose to gynaecological problems. Some patients experience recurring episodes of BV. This study's objective is to identify possible factors that may be associated with BV recurrence and describe the characteristics of these patients and interventions p...

PRKN/parkin-mediated mitophagy is induced by the probiotics Saccharomyces boulardii and...
https://doi.org/10.1080/15548627.2023.2172873
Autophagy Hawrysh PJ, Gao J et. al.

Jan 29th, 2023 - Mitochondrial impairment is a hallmark feature of neurodegenerative disorders, such as Parkinson disease, and PRKN/parkin-mediated mitophagy serves to remove unhealthy mitochondria from cells. Notably, probiotics are used to alleviate several symptoms of Parkinson disease including impaired locomotion and neurodegeneration in preclinical studies and constipation in clinical trials. There is som...

Narcolepsy secondary to anti-Ma2 encephalitis: two case reports.
https://doi.org/10.5664/jcsm.10448
Journal of Clinical Sleep Medicine : JCSM : Official Publ... Brunet de Courssou JB, Testard P et. al.

Jan 29th, 2023 - Recent studies suggest that sleep disorders are present in two-thirds of patient with autoimmune encephalitis. In anti-Ma2 encephalitis, hypersomnia appears to be frequent. However, only few cases of type 1 narcolepsy have been reported to date with anti-Ma2 encephalitis. We report two new cases of patients with narcolepsy secondary to anti-Ma2 encephalitis. Patient 1, a 68-year-old man, had na...

Central sleep apnea in patients with pontine tegmental cap dysplasia treated with suppl...
https://doi.org/10.5664/jcsm.10452
Journal of Clinical Sleep Medicine : JCSM : Official Publ... Ju Wang JD, Doherty D et. al.

Jan 29th, 2023 - This is the first case report of sleep-disordered breathing in patients with Pontine Tegmental Cap Dysplasia (PTCD), a very rare neurological disorder characterized by an anatomic malformation in the pons. Patients present with hypotonia, cognitive dysfunction and cranial nerve palsies (e.g., hearing loss, trigeminal anesthesia, and swallow dysfunction). Extensive studies have demonstrated the ...

A Multicenter Longitudinal MRI Study Assessing LeMan-PV Software Accuracy in the Detect...
https://doi.org/10.1002/jmri.28618
Journal of Magnetic Resonance Imaging : JMRI; Todea AR, Melie-Garcia L et. al.

Jan 29th, 2023 - Detecting new and enlarged lesions in multiple sclerosis (MS) patients is needed to determine their disease activity. LeMan-PV is a software embedded in the scanner reconstruction system of one vendor, which automatically assesses new and enlarged white matter lesions (NELs) in the follow-up of MS patients; however, multicenter validation studies are lacking. To assess the accuracy of LeMan-PV ...

Drug-drug interactions associated with FLT3 inhibitors for acute myeloblastic leukemia:...
https://doi.org/10.1080/17512433.2023.2174523
Expert Review of Clinical Pharmacology; Solana-Altabella A, Megías-Vericat JE et. al.

Jan 29th, 2023 - FLT3 inhibitors (FLT3i) are drugs in which there is limited experience and not yet enough information on the mechanisms of absorption, transport, and elimination; but especially on the potential drug-drug interactions (DDIs). There are therefore risks in the management of FLT3i DDIs (i.e., sorafenib, ponatinib, crenolanib, midostaurin, quizartinib, and gilteritinib) and ignoring them can compro...

Clinical remission in paired phase two and three studies in inflammatory bowel disease:...
https://doi.org/10.1097/MEG.0000000000002490
European Journal of Gastroenterology & Hepatology; Tandon P, Natt N et. al.

Jan 29th, 2023 - Discrepancies in phase two and three studies can result in significant patient and financial burden, as well as the nonapproval of potentially efficacious drugs. We aimed to determine whether this discrepancy exists for clinical trials in inflammatory bowel disease (IBD). Electronic databases (MEDLINE and Embase) and clinical trial repositories were searched from 1 January 1946 to 12 March 2021...

Impact of metformin on the incidence of human cholangiocarcinoma in diabetic patients: ...
https://doi.org/10.1097/MEG.0000000000002503
European Journal of Gastroenterology & Hepatology; Laffusa A, Ciaccio A et. al.

Jan 29th, 2023 - Cholangiocarcinoma (CCA) is the second most common liver cancer. Diabetes is a well-known risk factor; however, treatment with metformin has been reported to be protective for several cancers, but data on CCA are still sparse and heterogeneous. We performed this meta-analysis to investigate the role of metformin as a potential protective factor for CCA. In this systematic review and meta-analys...

Infectious mononucleosis is associated with an increased incidence of Crohn's disease: ...
https://doi.org/10.1097/MEG.0000000000002505
European Journal of Gastroenterology & Hepatology; Loosen SH, Kostev K et. al.

Jan 29th, 2023 - The pathogenesis of inflammatory bowel disease (IBD) has not been fully uncovered to date. Epstein-Barr-Virus (EBV) infection has recently been associated with the pathogenesis of multiple sclerosis, suggesting a general link between EBV and autoimmune diseases. However, data on an association between EBV and IBD have remained inconclusive. This study aims at evaluating an association between E...

Outcomes of immunomodulator and advanced therapies for primary sclerosing cholangitis-a...
https://doi.org/10.1097/MEG.0000000000002510
European Journal of Gastroenterology & Hepatology; Sayed A, Assis DN et. al.

Jan 29th, 2023 - Inflammatory bowel disease (IBD) coexists in up to 80% of patients with primary sclerosing cholangitis (PSC). The aim of this study is to investigate the outcomes of immunomodulator (IMM)/advanced therapies for the treatment of PSC-IBD. This was a single-center, retrospective study of patients with PSC from 1 January 2012 to 1 April 2021. Adult patients (age ≥ 18 years) with PSC-IBD were includ...

Iron chelation therapy.
https://doi.org/10.1111/ejh.13935
European Journal of Haematology; Bruzzese A, Martino EA et. al.

Jan 29th, 2023 - Iron overload is a pathological condition resulting from a congenital impairment of its regulation, increased intestinal iron absorption secondary to bone marrow erythroid hyperplasia, or a chronic transfusional regimen. In normal conditions, intracellular and systemic mechanisms contribute to maintaining iron balance. When this complex homeostatic mechanism fails, an iron overload could be pre...

Development and validation of a model for predicting the adult height of girls with idi...
https://doi.org/10.1007/s00431-023-04842-3
European Journal of Pediatrics; Wu W, Zhu X et. al.

Jan 29th, 2023 - The aim was to develop a model to predict the adult height (AH) of idiopathic central precocious puberty (ICPP) girls who underwent gonadotropin-releasing hormone analog (GnRHa) treatment. Data analysis included 258 girls with ICPP. Among them, 101 girls who reached final AH (FAH) with GnRHa treatment were analyzed to verify three previous prediction models and develop a unique model based on m...

Diagnostic and therapeutic cystoscopy in bladder pain syndrome/interstitial cystitis: s...
https://doi.org/10.1007/s00192-023-05449-w
International Urogynecology Journal; Taneja R, Pandey S et. al.

Jan 29th, 2023 - Cystoscopy has been routinely performed in patients suspected to be suffering from bladder pain syndrome/interstitial cystitis (BPS/IC) across the globe. The methodology reported by various guidelines appears to have differences in the techniques and hence there is a need for a review of all those techniques in order to arrive at a consensus. The aim was to review the literature describing the ...