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VIDEO: Neuromodulators offer relief for patients with superior limbic keratoconjunctivitis
https://www.healio.com/news/ophthalmology/20220209/video-neuromodulators-offer-relief-for-patients-with-superior-limbic-keratoconjunctivitis

Feb 9th, 2022 - WAIKOLOA, Hawaii — In this Healio Video Perspective from Hawaiian Eye 2022, Laura M. Periman, MD, discusses superior limbic keratoconjunctivitis and the potential use of neuromodulators to ease patients’ symptoms.

Lower bevacizumab doses, agents with less systemic exposure may be safer options for ROP
https://www.healio.com/news/ophthalmology/20220203/lower-bevacizumab-doses-agents-with-less-systemic-exposure-may-be-safer-options-for-rop

Feb 3rd, 2022 - WAIKOLOA, Hawaii — Systemic effects of anti-VEGF in retinopathy of prematurity have not been ruled out, so it may be wise to use bevacizumab in lower doses or switch to agents with less systemic exposure, according to one presenter. “The BEAT-ROP study demonstrated a beneficial effect for bevacizumab vs. laser in the treatment of zone I, stage 3+ ROP. But one thing I didn’t like was the complet...

VIDEO: Striving for ‘one and done’ with collagen cross-linking
https://www.healio.com/news/ophthalmology/20220126/video-striving-for-one-and-done-with-collagen-crosslinking

Jan 26th, 2022 - WAIKOLOA, Hawaii — In this Healio Video Perspective from Hawaiian Eye 2022, Kathryn M. Hatch, MD, explains why cornea specialists strive for “one and done” when treating keratoconus and other epithelial defects with collagen cross-linking.

VIDEO: ECP viable as stand-alone procedure, in combination with MIGS
https://www.healio.com/news/ophthalmology/20220125/video-ecp-viable-as-standalone-procedure-in-combination-with-migs

Jan 25th, 2022 - WAIKOLOA, Hawaii — In this Healio Video Perspective from Hawaiian Eye 2022, Michael Greenwood, MD, discusses the benefits of adding endoscopic cyclophotocoagulation to any minimally invasive glaucoma surgery.

Be cautious if considering use of premium IOLs in patients with glaucoma
https://www.healio.com/news/ophthalmology/20220121/be-cautious-if-considering-use-of-premium-iols-in-patients-with-glaucoma

Jan 21st, 2022 - WAIKOLOA, Hawaii — Surgeons need to consider the risks and possible refractive outcomes before implanting a premium IOL in a patient with glaucoma, according to a presentation at Hawaiian Eye 2022. Nathan Radcliffe, MD, said that when a patient with glaucoma who already has a premium IOL experiences a problem, the IOL is rarely the issue. “I never remove the premium IOL because as bad as the gl...

Take steps to manage pseudoexfoliation glaucoma in cataract surgery
https://www.healio.com/news/ophthalmology/20220119/take-steps-to-manage-pseudoexfoliation-glaucoma-in-cataract-surgery

Jan 19th, 2022 - WAIKOLOA, Hawaii — Keep the cornea in mind and protect the endothelium when managing pseudoexfoliation glaucoma during cataract surgery, a presenter said here. “Consider femto if at all possible to decrease the ultrasound and combine with angle surgery, but skip the implants to save the cornea,” Malik Y. Kahook, MD, said at Hawaiian Eye 2022. The second key is to target the angle first and earl...

Several pathways under investigation for dry AMD treatment
https://www.healio.com/news/ophthalmology/20220118/several-pathways-under-investigation-for-dry-amd-treatment

Jan 18th, 2022 - WAIKOLOA, Hawaii — Several pathways are under investigation for the treatment of dry age-related macular degeneration, according to a presentation at Retina 2022. “The big issue for us researchers is we don’t have a good animal model to test anything,” Peter K. Kaiser, MD, said. “We don’t have preclinical models that inform us if a drug is going to work or not because the animal that we use are...

VIDEO: Special considerations needed for premium IOLs in patients with glaucoma
https://www.healio.com/news/ophthalmology/20220118/video-special-considerations-needed-for-premium-iols-in-patients-with-glaucoma

Jan 18th, 2022 - WAIKOLOA, Hawaii — In this Healio Video Perspective from Hawaiian Eye 2022, John Berdahl, MD, of Vance Thompson Vision in Sioux Falls, South Dakota, spoke about premium and toric IOLs in patients with glaucoma. “I was actually quite surprised in an informal poll of the audience at how many surgeons did premium IOLs,” Berdahl said. “The vast majority of hands went up, but they actually stayed up...

Address ocular surface disease before surgery to optimize patient satisfaction
https://www.healio.com/news/ophthalmology/20220117/address-ocular-surface-disease-before-surgery-to-optimize-patient-satisfaction

Jan 17th, 2022 - WAIKOLOA, Hawaii — Diagnosing and treating ocular surface disease preoperatively is one of the elements that contribute to elevated patient satisfaction postoperatively, Marjan Farid, MD, said at Hawaiian Eye 2022. “We know that 50% of patients, at least, who come in for cataract surgery are asymptomatic, but at least 80% of those patients have at least one sign of dry eye disease,” Farid said ...

Medicare cuts, ASC rates, new FDA-approved drugs: Latest for 2022
https://www.healio.com/news/ophthalmology/20220117/medicare-cuts-asc-rates-new-fdaapproved-drugs-latest-for-2022

Jan 17th, 2022 - WAIKOLOA, Hawaii — Medicare payment changes, ASC payment rates and new FDA approved drugs were a few of the topics discussed in a presentation on 2022 updates for ophthalmic practices at Hawaiian Eye 2022. Paul M. Larson, MBA, MMSC, COMT, CPC, COE, CPMA, a senior consultant from Corcoran Consulting Group, said that the Medicare Physician Fee Schedule was just updated a few weeks ago. “With the ...

VIDEO: Dextenza helps reduce post-cataract surgery glaucoma drop burden
https://www.healio.com/news/ophthalmology/20210524/video-dextenza-helps-reduce-postcataract-surgery-glaucoma-drop-burden

May 24th, 2021 - WAILEA, Hawaii — In this Hawaiian Eye 2021 video, Savak “Sev” Teymoorian, MD, MBA, explains how Dextenza (dexamethasone, Ocular Therapeutix) intracanalicular inserts can reduce drop burden in patients with glaucoma after cataract surgery.

VIDEO: Lee explains how to identify NMOSD in patients with optic neuritis
https://www.healio.com/news/ophthalmology/20210521/video-lee-explains-how-to-identify-nmosd-in-patients-with-optic-neuritis

May 21st, 2021 - WAILEA, Hawaii — In this video from Hawaiian Eye 2021, Andrew G. Lee, MD, discusses the important questions ophthalmologists should ask patients with optic neuritis to identify neuromyelitis optica spectrum disorder.

VIDEO: Durysta helps patients overcome challenge of instilling glaucoma drops
https://www.healio.com/news/ophthalmology/20210521/video-durysta-helps-patients-overcome-challenge-of-instilling-glaucoma-drops

May 21st, 2021 - WAILEA, Hawaii — In this video at Hawaiian Eye 2021, Savak Teymoorian, MD, MBA, discusses how the Durysta bimatoprost implant 10 µg from Allergan obviates the need for patients with glaucoma to instill drops.

Home OCT with AI may be feasible for patients with wet AMD
https://www.healio.com/news/ophthalmology/20210518/holekamp-nm-home-oct-for-monitoring-namd-presented-at-retina-2021-may-814-2021-wailea-hawaii

May 18th, 2021 - WAILEA, Hawaii — The COVID-19 pandemic changed the way physicians monitor age-related macular degeneration, and Nancy M. Holekamp, MD, believes those changes are here to stay. “We all learned that remote monitoring of our patients is desirable, even if there isn’t a pandemic,” she said in her presentation at Retina 2021. “It currently exists with monitoring patients with intermediate AMD, and t...

VIDEO: Innovative technology reframes ‘controlled’ glaucoma
https://www.healio.com/news/ophthalmology/20210514/video-innovative-technology-reframes-controlled-glaucoma

May 14th, 2021 - WAILEA, Hawaii — In this video from Hawaiian Eye, I. Paul Singh, MD, discusses how innovative technology has changed his definition of controlled glaucoma.

Shields receives Philip M. Corboy, MD, award
https://www.healio.com/news/ophthalmology/20210513/shields-receives-phillip-m-corboy-md-award

May 13th, 2021 - WAILEA, Hawaii — M. Bruce Shields, MD, was awarded the Philip M. Corboy, MD, Memorial Award for Distinguished Service to Ophthalmology at Hawaiian Eye 2021. Shields was unable to attend the meeting but accepted the award by way of a recorded video. “I sure wish we could be with you, but I’m grateful to the organizing committee of the Hawaiian Eye meeting that we can at least join you virtually,...

VIDEO: Bedrood discusses experience with iStent inject
https://www.healio.com/news/ophthalmology/20210512/video-bedrood-discusses-experience-with-istent-inject

May 12th, 2021 - WAILEA, Hawaii — In this video from Hawaiian Eye 2021, Sahar Bedrood, MD, PhD, discusses how she has incorporated the iStent inject (Glaukos) into her practice, patient selection and the benefits of using the device in those with glaucoma.

VIDEO: Samuelson discusses best practices in combined glaucoma, cataract cases
https://www.healio.com/news/ophthalmology/20210512/video-samuelson-discusses-best-practices-in-combined-glaucoma-cataract-cases

May 12th, 2021 - WAILEA, Hawaii — In this video from Hawaiian Eye, Thomas W. Samuelson, MD, discusses the nuanced decision-making that goes into deciding which surgical interventions to use in patients with glaucoma who are also in need of cataract surgery.

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
https://doi.org/10.1002/art.41752
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

Fluconazole - fluconazole tablet-REMEDYREPACK INC.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d11e0926-cd15-49ba-b0ee-2b6d4e009dd8

Dec 30th, 2022 - Fluconazole tablets are indicated for the treatment of: Vaginal candidiasis (vaginal yeast infections due to Candida). Oropharyngeal and esophageal candidiasis. In open noncomparative studies of relatively small numbers of patients, fluconazole tablets were also effective for the treatment of Candida urinary tract infections, peritonitis, and systemic Candida infections including candidemia, di...

Ascor - ascorbic acid injection-McGuff Pharmaceuticals, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=388aad52-fc01-4784-9791-1dbc80c69306

Oct 1st, 2022 - ASCOR is vitamin C indicated for the short term (up to 1 week) treatment of scurvy in adult and pediatric patients age 5 months and older for whom oral administration is not possible, insufficient or contraindicated. Limitations of Use ASCOR is not indicated for treatment of vitamin C deficiency that is not associated with signs and symptoms of scurvy. ASCOR is vitamin C indicated for the short...

CDC: Up to Five Monkeypox Cases Now Presumed in the U.S.
https://www.medpagetoday.com/infectiousdisease/publichealth/98884
MedPage Today; Walker M.

May 24th, 2022 - With one confirmed case and four presumptive cases of monkeypox in the U.S., clinicians should continue to be on high alert if their patients report new onset of rash, especially in the genital or perianal area, CDC staff said Monday. The one confirmed case in Massachusetts had over 200 close contacts, the majority of whom were healthcare workers, said Capt. Jennifer McQuiston, DVM, deputy d...

Table - Duration of Infectious Virus Shedding by SARS-CoV-2 Omicron Variant–Infected Vaccinees
https://wwwnc-origin.cdc.gov/eid/article/28/5/22-0197-t1
Emerging Infectious Diseases;

May 11th, 2022 - Table: Overview of 18 cases of SARS-CoV-2 infection caused by the Omicron variant, Japan, November 29–December 18, 2021*

Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial
https://www.sciencedirect.com/science/article/pii/S0188440922000455?via=ihub
Archives of Medical Research; Villasis-Keever MA, .

Apr 18th, 2022 - Background . Associations between vitamin D (VD) deficiency and the risk of SARS-CoV-2 infection have been documented in cross-sectional population studies. Intervention studies in patients with moderate to severe COVID-19 have failed to consistently document a beneficial effect.

Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from th...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00327-0/fulltext
The Lancet; Menni C, .

Apr 7th, 2022 - On Nov 26, 2021, WHO designated the SARS-CoV-2 variant B.1.1.529 (omicron), first seen in South Africa, as a new variant of concern.1 Of the many mutations detected in omicron, more than 30 are in the spike protein and 15 are in the receptor-binding domain, which could affect transmission, disease presentation, and natural or vaccine-induced protective immunity.1 In the subsequent weeks, omicro...

Why the WHO took two years to say COVID is airborne
https://www.nature.com/articles/d41586-022-00925-7
Nature Lewis D.

Apr 6th, 2022 - Early in the pandemic, the World Health Organization stated that SARS-CoV-2 was not transmitted through the air. That mistake and the prolonged process of correcting it sowed confusion and raises questions about what will happen in the next pandemic.

Glasses and risk of COVID-19 transmission - analysis of the Virus Watch Community Cohort study
https://www.medrxiv.org/content/10.1101/2022.03.29.22272997v1
Medrxiv Navaratnam AM

Apr 4th, 2022 - Background Respiratory viruses, including SARS-CoV-2, can infect the eyes or pass into the nose via the nasolacrimal duct. The importance of transmission via the eyes is unknown but might plausibly be reduced in those who wear glasses. Previous studies have mainly focussed on protective eyewear in healthcare settings.

Dietary Supplements for Eye Conditions: What the Science Says
https://www.nccih.nih.gov/health/providers/digest/dietary-supplements-for-eye-conditions-science?nav=govdcd
NCCIH Clinical Digest for Health Professionals; National Center for Complementary and Integrative Health (NCCIH)

Mar 31st, 2022 - Findings from the Age-Related Eye Disease Studies (AREDS and AREDS2) suggest that dietary supplementation with antioxidant vitamins and zinc may slow the progression of age-related macular degeneration in people who have intermediate AMD and those who have late AMD in one eye.

Ambient air pollution and COVID-19 risk: Evidence from 35 observational studies
https://www.sciencedirect.com/science/article/pii/S0013935121013608?via=ihub
Environmental Research; Zang ST, .

Mar 30th, 2022 - Coronavirus disease 2019 (COVID-19) is induced by a previously undiscovered coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Lu et al., 2020). Since SARS-CoV-2 was first discovered in December 2019, as of April 25, 2021, more than four million fatalities have been attributed to COVID-19, accounting for approximately 2% of the infected cases (>214 million)...

Bimatoprost - bimatoprost solution/ drops-Lupin Pharmaceuticals, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ac853f64-50bd-4bff-9cbe-aac93ef5550f

Jul 1st, 2022 - Bimatoprost ophthalmic solution, 0.03% is a prostaglandin analog indicated for the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension. (1) Bimatoprost ophthalmic solution, 0.03% is indicated for the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension.

WHO consolidated guidelines on tuberculosis Module 5: Management of tuberculosis in children and adolescents
https://www.who.int/publications/i/item/9789240046764
World Health Organization (WHO)

Mar 21st, 2022 - The Updated guidelines on Management of tuberculosis in children and adolescents include new recommendations that cover diagnostic approaches for TB, shorter treatment for children with non-severe drug-susceptible TB, a new option for the treatment of TB meningitis, the use of bedaquiline and delamanid in young children with multidrug- and rifampicin-resistant TB and decentralized and family-ce...

Duration of Infectious Virus Shedding by SARS-CoV-2 Omicron Variant–Infected Vaccines
https://wwwnc.cdc.gov/eid/article/28/5/22-0197_article
Emerging Infectious Diseases; Takahash K, Ishikane M et. al.

Mar 15th, 2022 - To determine virus shedding duration, we examined clinical samples collected from the upper respiratory tracts of persons infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in Japan during November 29–December 18, 2021. Vaccinees with mild or asymptomatic infection shed infectious virus 6–9 days after onset or diagnosis, even after symptom resolution.

Vaccine Researcher Who Developed Tinnitus After COVID Shot Calls for Further Study
https://www.medpagetoday.com/special-reports/exclusives/97592
MedPage Today; Henderson J.

Mar 9th, 2022 - Gregory Poland, MD, director of the Mayo Clinic's Vaccine Research Group in Rochester, Minnesota, remains a steadfast vaccination advocate -- even though he developed tinnitus soon after receiving his second dose of COVID vaccine.

2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Kawasaki Disease
https://www.rheumatology.org/Portals/0/Files/Guideline-Management-Kawasaki-Disease.pdf
American College of Rheumatology; Gorelik M, .

Mar 8th, 2022 - Kawasaki disease (KD) is a medium vessel vasculitis as presented in the Chapel Hill Consensus Conference nomenclature system (1). It is 1 of 2 primary common vasculitis syndromes that predominantly affect children (the other being IgA vasculitis [Henoch-Schönlein]). KD is seen with relative frequency in young children, at an incidence rate of 25–50 cases per 100,000 persons per year in the U...

SARS-CoV-2 is associated with changes in brain structure in UK Biobank
https://www.nature.com/articles/s41586-022-04569-5
Nature Douaud G, .

Mar 7th, 2022 - There is strong evidence for brain-related abnormalities in COVID-191–13. It remains unknown however whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing to brain pathology. Here, we investigated brain changes in 785 UK Biobank participants (aged 51–81) imaged twice, including 401 cases who tested positive for i...

Molnupiravir’s authorisation was premature
https://www.bmj.com/content/376/bmj.o443
BMJ Brophy JM.

Mar 3rd, 2022 - On 1 October 2021 Merck issued a press release1 reporting an interim analysis of Move-Out, a phase 3 randomised placebo controlled trial in unvaccinated adults with confirmed SARS-Co-V infection and mild-to-moderate symptoms outside hospital. The press release stated that molnupiravir, a nucleoside analogue that inhibits viral replication by mutagenesis, reduced risk of hospital admission or de...

An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques
https://www.biorxiv.org/content/10.1101/2022.02.25.481974v1
BioRxiv Madden PJ, .

Feb 28th, 2022 - Because of the recognized systemic nature of SARS-CoV-2 infection, a non-invasive and unbiased method is needed to clarify its spatiotemporal dynamics in vivo after transmission. We recently developed a probe based on the anti-SARS-CoV-2 spike antibody CR3022 to study SARS-CoV-2 pathogenesis in vivo. Herein, we describe its use in immunoPET to investigate SARS-CoV-2 infection of rhesus macaques.

SARS-CoV-2 emergence very likely resulted from at least two zoonotic events
https://zenodo.org/record/6291628
Zenodo Pekar JE, .

Feb 26th, 2022 - Understanding the circumstances that lead to pandemics is critical to their prevention. Here, we analyze the pattern and origin of genomic diversity of SARS-CoV-2 early in the COVID-19 pandemic. We show that the SARS-CoV-2 genomic diversity prior to February 2020 comprised only two distinct viral lineages—denoted A and B—with no transitional haplotypes. Novel phylodynamic rooting methods, coupl...

Evolving Patterns of Metastasis in Renal Cell Carcinoma: Do We Need to Perform Routine Bone Imaging?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523177/
Journal of Kidney Cancer and VHL; Lin J

Oct 13th, 2021 - Advance diagnostic and treatment modalities have improved outcomes for renal cell carcinoma (RCC) patients, but the prognosis for those with metastatic disease (mRCC) remains poor. As given metastatic distribution is critical in guiding treatment decisions for mRCC patients, we evaluated evolving metastatic patterns to assess if our current practice standards effectively address patient needs.

Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line
https://www.mdpi.com/1467-3045/44/3/73/htm
Current Issues in Molecular Biology; Aldén M, .

Feb 25th, 2022 - Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro.

Germline Variants Identified in Patients with Early-onset Renal Cell Carcinoma Referred for Germline Genetic Testing
https://pubmed.ncbi.nlm.nih.gov/34654685/
European Urology Oncology; Truong H

Oct 12th, 2021 - Despite guidelines recommending genetic counseling for patients with early-onset renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations and clinical associations in patients with early-onset RCC are lacking.

Moxifloxacin - moxifloxacin solution/ drops-Lupin Pharmaceuticals, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ae77e219-8af9-4aa4-96d3-05c9726a1d3c

Jun 6th, 2022 - Moxifloxacin ophthalmic solution, 0.5% is a topical fluoroquinolone anti- infective indicated for the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: Corynebacterium species*, Micrococcus luteus*, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus warneri*, Streptococcus pneumonia...

Surveillance of SARS-CoV-2 in the environment and animal samples of the Huanan Seafood Market
https://www.researchsquare.com/article/rs-1370392/v1
Research Square; Gao G, .

Feb 22nd, 2022 - Emerging in December 2019, coronavirus disease 2019 (COVID-19) eventually became a pandemic and has posed a tremendous threat to global public health. However, the origins of SARS-CoV-2, the causative agent of COVID-19, remain to be determined. It has reported that a certain number of the early case clusters had a contact history with Huanan Seafood Market.

Covid-19: Antibodies after AstraZeneca and Pfizer vaccines decrease with age and are higher in women, data show
https://www.bmj.com/content/376/bmj.o428
BMJ Iacobucci G.

Feb 18th, 2022 - SARS-CoV-2 antibody levels after receiving the AstraZeneca or Pfizer-BioNTech vaccine decrease with age and are higher in females and people with prior infection, show data from the Real-time Assessment of Community Transmission (React-2) study.1

Procentra - dextroamphetamine sulfate solution-Independence Pharmaceuticals, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1548cce2-fb6b-4f17-8a3b-868933f6c9d6

Jun 1st, 2022 - ProCentra ® (dextroamphetamine sulfate) Oral Solution is indicated in: Narcolepsy Attention Deficit Disorder with Hyperactivity: As an integral part of a total treatment program that typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in pediatric patients (ages 3 years to 16 years) with a behavioral syndrome characterized by the following gr...

Quetiapine fumarate - quetiapine fumarate tablet, extended release-Lupin Pharmaceuticals, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7803a290-91c0-4e7f-90b5-d2ff33a46cee

Jun 1st, 2022 - Quetiapine extended-release tablet is an atypical antipsychotic indicated for the treatment of: Schizophrenia (1.1) Bipolar I disorder, manic or mixed episodes (1.2) Bipolar disorder, depressive episodes (1.2) Major depressive disorder, adjunctive therapy with antidepressants (1.3) Quetiapine extended-release tablet is indicated for the treatment of schizophrenia. The efficacy of quetiapine ext...

Imatinib mesylate - imatinib mesylate tablet, film coated-Apotex Corp
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0291eca5-7a1d-4a79-30be-252224d96509

May 30th, 2022 - Imatinib mesylate is a kinase inhibitor indicated for the treatment of: • Newly diagnosed adult and pediatric patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase (1.1) • Patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in blast crisis (BC), accelerated phase (AP), or in chronic phase (CP) after failure of interferon...

Optimization of therapy in patients with epilepsy and psychiatric comorbidities: key po...
https://doi.org/10.2174/1570159X20666220526144314
Current Neuropharmacology; Pisani F, Rosa Pisani L et. al.

May 28th, 2022 - Psychiatric disorder comorbidity in patients with epilepsy (PWE) is very frequent with a mean percentage prevalence of up to 50% and even higher. Such a high frequency suggests that epilepsy and psychiatric disorders might share common pathological pathways. Various aspects contribute to make the matter very complex from a therapeutic point of view. Some antiseizure medications (ASMs), namely v...

Ursodeoxycholic acid (UDCA) reduces hepatocyte apoptosis by inhibiting farnesoid X rece...
https://doi.org/10.2174/1566524022666220525152811
Current Molecular Medicine; Wang L, Rui X et. al.

May 28th, 2022 - Hemorrhagic shock (HS) is the most common cause of potentially preventable death after traumatic injury. Acute liver injury is an important manifestation of HS. Apoptosis plays an important role in liver injury. Farnesoid X receptor (FXR) can alleviate liver injury. We designed this experiment to study the effects of ursodeoxycholic acid (UDCA) on hepatocyte apoptosis in HS and its relationship...

RUNX2 Regulates Osteoblast Differentiation via the BMP4 Signaling Pathway.
https://doi.org/10.1177/00220345221093518
Journal of Dental Research; Liu D, Zhang C et. al.

May 28th, 2022 - RUNX2 is a master osteogenic transcription factor, and mutations in RUNX2 cause the inherited skeletal disorder cleidocranial dysplasia (CCD). Studies have revealed that RUNX2 is not only a downstream target of the bone morphogenetic protein (BMP) pathway but can also regulate the expression of BMPs. However, the underlying mechanism of the regulation of BMPs by RUNX2 remains unknown. In this p...

HERVs role in the pathogenesis, diagnosis or prognosis of aging diseases: A systematic ...
https://doi.org/10.2174/1566524022666220525144135
Current Molecular Medicine; Prieto-Oliveir P

May 28th, 2022 - HERVs are humans endogenous retroviruses, which represent about 8% of human genome, and have various physiological functions, specially in pregnancy, embryo development and placenta formation. However, their involvement in diseases is not well defined. Some studies observed changes in HERVs expression according to age. Therefore, the aim of this systematic review was to analyze their role in pa...

MicroRNAs and their implications in CD4+ T-cells, oligodendrocytes and dendritic cells ...
https://doi.org/10.2174/1566524022666220525150259
Current Molecular Medicine; Safari A, Madadi S et. al.

May 28th, 2022 - MicroRNAs (miRNAs) have been established as key players in various biological processes regulating differentiation, proliferation, inflammation, and autoimmune disorders. Emerging evidence suggests the critical role of miRNAs in the pathogenesis of multiple sclerosis (M.S.). Here, we provide a comprehensive overview on miRNAs which are differentially expressed in M.S. patients or experimental a...

Ferroptosis inhibitor regulates the disease progression of systematic lupus erythematos...
https://doi.org/10.2174/1566524022666220525144630
Current Molecular Medicine; Yang B, Hou S et. al.

May 28th, 2022 - Systematic lupus erythematosus (SLE) is an autoimmune-mediated disease. So far, there is no relevant report on ferroptosis in SLE research, and the role of T helper 1 (Th1) and T helper 2 (Th2) cells in SLE is still unclear. This study employed SLE mice models with and without ferroptosis inhibitors(Liproxstatin‑1) and normal control mice. Treated mice were zanalyzed with hematoxylin and eosin ...

Current Strategies for the Treatment of Hepatocellular Carcinoma by Modulating the Tumo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128750
International Journal of Nanomedicine; Huang Y, Wang T et. al.

May 28th, 2022 - Liver cancer remains a global health challenge with a projected incidence of over one million cases by 2025. Hepatocellular carcinoma (HCC) is a common primary liver cancer, accounting for about 90% of all liver cancer cases. The tumor microenvironment (TME) is the internal and external environment for tumor development, which plays an important role in tumorigenesis, immune escape and treatmen...

Intercellular Communication-Related Molecular Subtypes and a Gene Signature Identified ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127593
Disease Markers; Guan P, Cai W et. al.

May 28th, 2022 - The tumor microenvironment (TME) of lung adenocarcinoma (LUAD) comprise various cell types that communicate with each other through ligand-receptor interactions. This study focused on the identification of cell types in LUAD by single-cell RNA sequencing (scRNA-seq) data and screening of intercellular communication-related genes. The Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm....

A Mechanistic Insight into the Pathogenic Role of Interleukin 17A in Systemic Autoimmun...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129985
Mediators of Inflammation; Bisoendial R, Lubberts E

May 28th, 2022 - Interleukin 17A (IL-17A) has been put forward as a strong ally in our fight against invading pathogens across exposed epithelial surfaces by serving an antimicrobial immunosurveillance role in these tissues to protect the barrier integrity. Amongst other mechanisms that prevent tissue injury mediated by potential microbial threats and promote restoration of epithelial homeostasis, IL-17A attrac...

Application of the CT/MRI LI-RADS Treatment Response Algorithm to Contrast-Enhanced Ult...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128751
Journal of Hepatocellular Carcinoma; Ruan SM, Cheng MQ et. al.

May 28th, 2022 - The contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) treatment response algorithm (TRA) is still in development. The aim of this study was to explore whether the CT/MRI LI-RADS TRA features were applicable to CEUS in evaluating the liver locoregional therapy (LRT) response. This study was a retrospective review of a prospectively maintained database of patie...

Case Report: Recurrent Malignant Struma Ovarii With Hyperthyroidism and Metastases, A R...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127674
Pathology Oncology Research : POR; Zhang R, Tian X et. al.

May 28th, 2022 - Background: SO (Struma ovarii) is a rare form of ovarian teratoma which originates from ovarian dermoid cysts. Due to the rarity of this disease, relevant studies might not be sufficiently documented, especially cases with hyperthyroidism and multiple metastases. Case Presentation: A 40-year-old female patient was admitted to our hospital due to management of early pregnancy along with a recurr...

Pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects.
https://doi.org/10.1017/S1368980022001318
Public Health Nutrition; Suhl J, Conway KM et. al.

May 28th, 2022 - To explore associations between maternal pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects. Population-based, case-control study using maternal responses to a dietary assessment and published arsenic concentration estimates in food items to calculate average daily total and inorganic arsenic exposure during the year before pregnancy. Assigning tertiles of total and inorgan...

Breathing in Duchenne muscular dystrophy: Translation to therapy.
https://doi.org/10.1113/JP281671
The Journal of Physiology; Mhandire DZ, Burns DP et. al.

May 28th, 2022 - Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disease caused by a deficiency in dystrophin - a structural protein which stabilizes muscle during contraction. Dystrophin deficiency adversely affects the respiratory system leading to sleep-disordered breathing, hypoventilation, and weakness of the expiratory and inspiratory musculature, which culminate in severe respiratory dysfu...

Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for...
https://doi.org/10.1080/22221751.2022.2081619
Emerging Microbes & Infections; Li H, Han X et. al.

May 28th, 2022 - Cryptococcal meningoencephalitis (CM) is emerging as an infection in HIV/AIDS patients shifted from primarily ART- naive to ART-experienced individuals, as well as patients with COVID-19 and immunocompetent hosts. This fungal infection is mainly caused by the opportunistic human pathogen Cryptococcus neoformans. Brain or central nervous system (CNS) dissemination is the deadliest process for th...

Distinct morphology of cardiac- and brown adipose tissue-projecting neurons in the stel...
https://doi.org/10.14814/phy2.15334
Physiological Reports; Barrett MS, Hegarty DM et. al.

May 28th, 2022 - Sympathetic neurons that innervate the heart are located primarily in the stellate ganglia (SG), which also contains neurons that project to brown adipose tissue (BAT). These studies were designed to examine the morphology of these two populations (cardiac- and BAT-projecting) and their target connectivity. We examined SG neurons in C57BL/6J mice following injections of the retrograde tracer ch...

Severe hypocalcemia mimicking acute ST-segment elevation myocardial infarction: Paradig...
https://doi.org/10.5603/CJ.a2022.0048
Cardiology Journal; Peiro B, Cerdán L et. al.

May 28th, 2022 - Severe hypocalcemia mimicking acute ST-segment elevation myocardial infarction: Paradigmatic case and review of literature.|2022|Peiro B,Cerdán L,Diarte JA,Ortas MR,Cortés C,|

Pathogenesis of pneumonia and acute lung injury.
https://doi.org/10.1042/CS20210879
Clinical Science (London, England : 1979); Long ME, Mallampalli RK et. al.

May 28th, 2022 - Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary and critical care healthcare professionals, and these challenges have recently garnered global attention due to the ongoing Sars-CoV-2 pandemic. One limitation to translational investigation of acute lung injury, including its most severe manifestation (acute respiratory distress syndrome, ARDS) has been hete...

Supportive management of patients with pheochromocytoma/paraganglioma undergoing noninv...
https://doi.org/10.1097/MED.0000000000000724
Current Opinion in Endocrinology, Diabetes, and Obesity; Talvacchio S, Nazari MA et. al.

May 28th, 2022 - Many publications review perioperative management of pheochromocytomas/paragangliomas (PPGLs); however, a large population, including 10-20% of metastatic PPGL patients, have inoperable disease. This has necessitated the development of noninvasive treatments (e.g., radio/chemotherapy), which, in affording disease-modification, have led to an ever-growing population of surviving patients with in...

The uncommon forms of congenital adrenal hyperplasia.
https://doi.org/10.1097/MED.0000000000000727
Current Opinion in Endocrinology, Diabetes, and Obesity; Auchus RJ

May 28th, 2022 - Clinicians recognize 21-hydroxylase deficiency as the most common form of congenital adrenal hyperplasia (CAH), and many papers have been published on this condition. In contrast, much less awareness has been addressed to the other, rare forms of CAH. The second most common form of CAH varies with country and ethnic background. In Brazil, 17-hydroxylase/17,20-lyase deficiency is the second most...

Efficacy and safety of combined Fractional ablative CO2 laser and 5 fluorouracil (5-FU)...
https://doi.org/10.1111/jocd.15116
Journal of Cosmetic Dermatology; Weshahy R, Abdelhamid MF et. al.

May 28th, 2022 - Acral lesions of vitiligo are most likely recalcitrant to the known lines of treatment. Ablative fractional CO2 has shown efficacy in treatment of vitiligo in combination with other modalities. Thirty non-segmental vitiligo patients with acral lesion were included in the study. Each patient was subjected to fractional Carbon Dioxide Laser Treatment followed by application of 5 fluorouracil (5FU...

Efficacy and safety of metformin in pregnant women with polycystic ovary syndrome: a sy...
https://doi.org/10.1080/09513590.2022.2080194
Gynecological Endocrinology : the Official Journal of The... Zhao Q, He J

May 28th, 2022 - To evaluate the efficacy and safety of using metformin in pregnant women with polycystic ovarian syndrome (PCOS) and to explore the most effective and safe protocol by using a meta-analysis method. Medline, EMBASE, Cochrane Library, and other databases were searched for randomized controlled trials and prospective cohort studies enrolling pregnant women with PCOS on receiving metformin or place...

Pharmacologic Treatment and Management of Bipolar Disorder in Adolescents.
https://doi.org/10.1080/14656566.2022.2083954
Expert Opinion on Pharmacotherapy; Elsayed OH, Pahwa M et. al.

May 28th, 2022 - The importance of the appropriate therapeutic interventions in children and adolescents with bipolar disorder (BD) cannot be overstated since treatment choices and their consequences may have effects into adulthood. Randomized clinical trials (RCTs) investigating treatment of mania, bipolar depression, and maintenance in adolescents with BD are reviewed. When RCTs are not available or are inade...

Evaluating fostamatinib disodium as a treatment option for immune thrombocytopenia in a...
https://doi.org/10.1080/14656566.2022.2082283
Expert Opinion on Pharmacotherapy; Dierickx D, Neefs J

May 28th, 2022 - Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by increased platelet destruction and decreased platelet production, leading to thrombocytopenia with or without bleeding manifestations. The majority of patients experiencing treatment need will eventually need secondary treatment following first line therapy with steroids. In 2018, the oral spleen tyrosine kinase i...

Tazemetostat Shows Antitumor Activity in Malignant Pleural Mesothelioma.
https://doi.org/10.1158/2159-8290.CD-RW2022-096
Cancer Discovery;

May 28th, 2022 - The primary endpoint of disease control rate at 12 weeks was met with a partial response in two patients.

Non-Mutated Nucleophosmin 1 Is Recognized by the CD8+ T Lymphocytes of an AML Patient a...
https://doi.org/10.3390/curroncol29050239
Current Oncology (Toronto, Ont.); Nemeckova S, Alexova-Zurkova K et. al.

May 28th, 2022 - Nucleophosmin (NPM1, B23) is a multifunctional phosphoprotein expressed in all tissues. The protein is mainly localized in nucleoli. In hematological malignancies, NPM1 belongs to commonly altered genes. Its mutation, always heterozygous, leads to the re-localization of the NPM1 protein from the nucleolus to the cytoplasm (NPM1c+). NPM1c+ is found in 30% of acute myeloid leukemia (AML). Our stu...

Primary Extra-Pleura Leiomyoma: A Case Report and Literature Review.
https://doi.org/10.3390/curroncol29050240
Current Oncology (Toronto, Ont.); Ullah A, Patterson GT et. al.

May 28th, 2022 - Leiomyomas are a common type of benign soft tissue tumor arising from smooth muscle, most often occurring within females' genitourinary and gastrointestinal tract. However, primary leiomyomas of the chest wall residing in the extra-pleural space are an extremely rare subset of leiomyomatous lesion presentation. We present a case of a fifty-two-year-old male who initially presented complaining o...

Enrichment-Free Single-Cell Detection and Morphogenomic Profiling of Myeloma Patient Sa...
https://doi.org/10.3390/curroncol29050242
Current Oncology (Toronto, Ont.); Ndacayisaba LJ, Rappard KE et. al.

May 28th, 2022 - Multiple myeloma is an incurable malignancy that initiates from a bone marrow resident clonal plasma cell and acquires successive mutational changes and genomic alterations, eventually resulting in tumor burden accumulation and end-organ damage. It has been recently recognized that myeloma secondary genomic events result in extensive sub-clonal heterogeneity both in localized bone marrow areas ...

Intravascular Large B-Cell Lymphoma: A Review with a Focus on the Prognostic Value of S...
https://doi.org/10.3390/curroncol29050237
Current Oncology (Toronto, Ont.); Breakell T, Waibel H et. al.

May 28th, 2022 - Intravascular large B-cell lymphoma (IVLBCL) is an aggressive Non-Hodgkin lymphoma (NHL) characterised by the presence of neoplastic lymphoid cells within small- and medium-sized blood vessels. According to the clinical presentation, the current WHO classification distinguishes the 'classic' (formerly 'Western') from a hemophagocytic syndrome-associated (formerly 'Asian') variant. A third 'cuta...

Cutaneous Involvement in Diseases with Plasma Cell Differentiation: Diagnostic Approach.
https://doi.org/10.3390/curroncol29050246
Current Oncology (Toronto, Ont.); Zanelli M, Palicelli A et. al.

May 28th, 2022 - Neoplasms with plasma cell differentiation may occasionally involve the skin. Cutaneous lesions may represent the first sign of an underlying systemic plasma cell malignancy, such as multiple myeloma, or the skin itself may be the primary site of occurrence of a hematological tumor with plasma cell differentiation. Starting from examples encountered in our daily practice, we discussed the diagn...

Immune Checkpoint Inhibitors in Cancer Therapy.
https://doi.org/10.3390/curroncol29050247
Current Oncology (Toronto, Ont.); Shiravand Y, Khodadadi F et. al.

May 28th, 2022 - The discovery of immune checkpoint proteins such as PD-1/PDL-1 and CTLA-4 represents a significant breakthrough in the field of cancer immunotherapy. Therefore, humanized monoclonal antibodies, targeting these immune checkpoint proteins have been utilized successfully in patients with metastatic melanoma, renal cell carcinoma, head and neck cancers and non-small lung cancer. The US FDA has succ...

STR Profiling Reveals Tumor Genome Instability in Primary Mediastinal B-Cell Lymphoma.
https://doi.org/10.3390/curroncol29050278
Current Oncology (Toronto, Ont.); Risinskaya N, Mangasarova Y et. al.

May 28th, 2022 - Primary mediastinal B-cell lymphoma (PMBCL) is the only non-Hodgkin's lymphoma variant responding to immune checkpoint inhibitor (ICI) therapy, approximately in half of the cases; however, no molecular markers predicting a response to ICI therapy in PMBCL have been described so far. In this study, we assessed the incidence of the loss of heterozygosity (LOH), elevated microsatellite alteration ...

Successful Treatment with Selpercatinib for Ectopic Cushing's Syndrome Due to Medullary...
https://doi.org/10.3390/curroncol29050282
Current Oncology (Toronto, Ont.); Ragnarsson O, Piasecka M et. al.

May 28th, 2022 - Selpercatinib, a RET kinase inhibitor, is an effective treatment for patients with medullary thyroid cancer with RET mutations. In this paper, we present the case of a 62-year-old man with ectopic Cushing's syndrome due to medullary thyroid cancer who received treatment with selpercatinib. Six months later, all the cushingoid features had resolved, and s-calcitonin had decreased from 580 pmol/L...

Efficacy of Osimertinib in Lung Squamous Cell Carcinoma Patients with EGFR Gene Mutatio...
https://doi.org/10.3390/curroncol29050285
Current Oncology (Toronto, Ont.); Rekowska A, Rola P et. al.

May 28th, 2022 - Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and the leading cause of cancer-related mortality worldwide. It is responsible for 80-85% of lung cancer cases. NSCLC can be divided into several groups, led by adenocarcinoma (ADC)-40-50% and squamous cell carcinoma (SCC)-20-30%. The development of new molecular therapies targeting particular abnormalities such as mutati...

Hamartochondroma Pleural Lesion Mimicking Liposarcoma: A Case Report.
https://doi.org/10.3390/curroncol29050281
Current Oncology (Toronto, Ont.); Drevet G, Kovacs E et. al.

May 28th, 2022 - Heterogeneous masses developing in the pleural cavity are most often malignant and can pose diagnostic challenges. Fibrous tumors of the pleura, liposarcoma, thymoma or lipoma most frequently affect this anatomic area. Surgical exploration and resection are often mandatory to make the definitive diagnosis. We report the case of a 54-year-old women who presented with an epigastric and right sub ...

The Role of Microorganisms in Appendiceal Pseudomyxoma Peritonei: A Review.
https://doi.org/10.3390/curroncol29050289
Current Oncology (Toronto, Ont.); Khamzina Y, King MC et. al.

May 28th, 2022 - Pseudomyxoma peritonei (PMP) is a rare clinical syndrome. It originates from neoplasms of the appendix and leads to the formation of peritoneal implants and the accumulation of mucinous ascites. PMP represents a spectrum of low to high-grade disease. Despite aggressive management, many PMP patients recur, leading to debilitating symptoms and few treatment options. Therefore, scientists have con...

CAR T Cell Therapy for Chronic Lymphocytic Leukemia: Successes and Shortcomings.
https://doi.org/10.3390/curroncol29050293
Current Oncology (Toronto, Ont.); Todorovic Z, Todorovic D et. al.

May 28th, 2022 - Chimeric antigen receptor T (CAR T) cell therapy achieved remarkable success in B-cell leukemia and lymphoma which led to its incorporation in treatment protocols for these diseases. CAR T cell therapy for chronic lymphocytic leukemia (CLL) patients showed less success compared to other malignant tumors. In this review, we discuss the published results regarding CAR T cell therapy of CLL, possi...

De-Escalation Strategies for Human Papillomavirus-Associated Oropharyngeal Squamous Cel...
https://doi.org/10.3390/curroncol29050295
Current Oncology (Toronto, Ont.); Silver JA, Turkdogan S et. al.

May 28th, 2022 - The prevalence of oropharyngeal squamous cell carcinoma has been increasing in North America due to human papillomavirus-associated disease. It is molecularly distinct and differs from other head and neck cancers due to the young population and high survival rate. The treatment regimens currently in place cause significant long-term toxicities. Studies have transitioned from mortality-based out...

Gemcitabine and Cisplatin as Neo-Adjuvant for Cholangiocarcinoma Patients Prior to Live...
https://doi.org/10.3390/curroncol29050290
Current Oncology (Toronto, Ont.); Abdelrahim M, Al-Rawi H et. al.

May 28th, 2022 - The management of cholangiocarcinoma is continually reviewed on a current evidence basis to develop practice guidelines and consensus statements. However, the standardized treatment guidelines are still unclear for cholangiocarcinoma patients who are listed for liver transplantation. We aimed to validate and evaluate the potential efficacy of chemotherapy combination of Gemcitabine and Cisplati...

Treatment Outcomes for Primary Hepatic Angiosarcoma: National Cancer Database Analysis ...
https://doi.org/10.3390/curroncol29050292
Current Oncology (Toronto, Ont.); Mangla A, Cioffi G et. al.

May 28th, 2022 - To determine the risk of mortality and factors associated with survival amongst patients diagnosed with primary hepatic angiosarcoma (PHA). All patients diagnosed with hepatocellular carcinoma (HCC) or PHA from 2004 to 2014 were identified from the National Cancer Database (NCDB). Further analysis was performed within the cohort of patients with PHA to assess the impact of surgery, chemotherapy...

Patient Experience with a Gynecologic Oncology-Initiated Genetic Testing Model for Wome...
https://doi.org/10.3390/curroncol29050288
Current Oncology (Toronto, Ont.); Sadinsky MB, Power J et. al.

May 28th, 2022 - Up to 20% of women diagnosed with tubo-ovarian carcinoma carry a germline pathogenic variant in a cancer-predisposing gene (e.g., BRCA1/BRCA2). Identifying these variants can help to inform eligibility for therapies, guide surveillance and prevention of new primary cancers, and assess risk to family members. The Gynecologic Oncology-Initiated Genetic Testing Model (GOIGT) was initiated at the M...

The Effect of Surgeon Volume on the Outcome of Laser Vaporization: A Single-Center Retr...
https://doi.org/10.3390/curroncol29050302
Current Oncology (Toronto, Ont.); Maeda M, Hisa T et. al.

May 28th, 2022 - Although laser vaporization is a popular minimally invasive treatment for cervical intraepithelial neoplasia (CIN), factors influencing CIN recurrence are understudied. Moreover, the effect of surgeon volume on patients' prognosis after laser vaporization for CIN is unknown. This single-center retrospective study evaluated the predictive value of surgeon volume and patient characteristics for l...

Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion and ...
https://doi.org/10.1158/1078-0432.CCR-21-3039
Clinical Cancer Research : an Official Journal of the Ame... Wang W, Lozar T et. al.

May 28th, 2022 - We investigated whether in human head and neck squamous cell carcinoma (HNSCC) high levels of expression of stress keratin 17 (K17) are associated with poor survival and resistance to immunotherapy. We investigated the role of K17 in regulating both the tumor microenvironment and immune responsiveness of HNSCC using a syngeneic mouse HNSCC model, MOC2. MOC2 gives rise to immunologically cold tu...

Nucleophosmin 1: from its pathogenic role to a tantalizing therapeutic target in acute ...
https://doi.org/10.1080/16078454.2022.2067939
Hematology (Amsterdam, Netherlands); Shi Y, Xue Y et. al.

May 28th, 2022 - Nucleophosmin 1 (NPM1, also known as B23) is a multifunctional protein involved in a variety of cellular processes, including ribosomal maturation, centrosome replication, maintenance of genomic stability, cell cycle control, and apoptosis. NPM1 is the most commonly mutated gene in adult acute myeloid leukemia (AML) and is present in approximately 40% of all AML cases. The underlying mechanisms...

A Review of Disease Mechanisms and Current and Emerging Treatment Options for Generaliz...
https://doi.org/10.4088/PCC.AR21018WC2C
The Primary Care Companion for CNS Disorders; Bril V, Silvestri NJ et. al.

May 28th, 2022 - Generalized myasthenia gravis (gMG) is a disease resulting from impaired neuromuscular transmission due to presence of antibodies that block acetylcholine receptors. Autoantibodies to acetylcholine receptors directly impair the activity of ion channels that conduct nerve impulses, and cross-link acetylcholine receptors resulting in complement-mediated destruction, further worsening functional i...

Clinical risk factors for patients with myelodysplastic syndromes undergoing allogeneic...
https://doi.org/10.1080/16078454.2022.2052601
Hematology (Amsterdam, Netherlands); Teshigawara-Tanabe H, Hagihara M et. al.

May 28th, 2022 - Objectives: Allogeneic hematopoietic stem cell transplantation (allo-HCT) is the only curative treatment for myelodysplastic syndromes (MDS), although predicting post-transplant outcomes remains inconclusive. This study evaluated patients who underwent allo-HCT for MDS to identify prognostic factors and develop a clinical risk model.Methods: We evaluated 55 patients between June 2000 and March ...

Fueling the fire in the gut.
https://doi.org/10.1084/jem.20220723
The Journal of Experimental Medicine; Lin CH, Lu LF

May 28th, 2022 - Gut dysbiosis has long been associated with the development of Crohn's disease and other gastrointestinal disorders. Otake-Kasamoto et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20211291) report that dysbiotic microbiota-derived bioactive lipids, lysophosphatidylserines, can promote pathological Th1 cell responses through inducing metabolic reprogramming and epigenetic changes.

6 and 12-Month Outcomes After 90:10 Enteral Nutrition Induction Therapy in Pediatric Cr...
https://doi.org/10.1097/MPG.0000000000003475
Journal of Pediatric Gastroenterology and Nutrition; Davidson N, Rutsky J et. al.

May 28th, 2022 - Studies describing longer-term outcomes after EEN induction are limited. We describe clinical outcomes during 90:10 EN induction, and 6- and 12- month outcomes among patients that successfully completed EN induction and then continued either EN or immunomodulator (IM) maintenance therapy. All children with CD treated with 90:10 EN induction protocol (90% formula:10% regular diet) at our IBD Cen...

Identification of a Germline Pyrin Variant in a Metastatic Melanoma Patient With Multip...
https://doi.org/10.1097/CJI.0000000000000425
Journal of Immunotherapy (Hagerstown, Md. : 1997); Oswalt CJ, Al-Rohil RN et. al.

May 28th, 2022 - The mechanisms underlying tumor immunosurveillance and their association with the immune-related adverse events (irAEs) associated with checkpoint inhibitor immunotherapies remain poorly understood. We describe a metastatic melanoma patient exhibiting multiple episodes of spontaneous disease regression followed by the development of several irAEs during the course of anti-programmed cell death ...

AML with inv(16)/t(16;16) and high-risk cytogenetic abnormalities: atypical features an...
https://doi.org/10.1080/16078454.2022.2078027
Hematology (Amsterdam, Netherlands); Assaf N, Lefebvre C et. al.

May 28th, 2022 - Acute myeloid leukemia (AML) with inv(16)/t(16;16) is among the most frequent AML subtypes. It is recognized by the detection of the CBFB-MYH11 fusion which confers a favorable prognosis, irrespective of the presence of secondary cytogenetic abnormalities. However, the effect of additional genetic anomalies on the behavior of inv(16) AML is debatable. Recent case reports describe an unfavorable...

ASO Author Reflections: Importance of Preoperative Diagnosis of Lymph Node Metastasis i...
https://doi.org/10.1245/s10434-022-11933-2 10.1007/s00268-018-4654-2 10.1097/SLA.0000000000000584 10.1002/jhbp.1044 10.1016/j.hpb.2018.08.017 10.1007/s00276-018-2135-9 10.1245/s10434-020-08306-y 10.1245/s10434-020-08445-2 10.1245/s10434-022-11931-4
Annals of Surgical Oncology; Hosokawa I, Togasaki K et. al.

May 28th, 2022 - ASO Author Reflections: Importance of Preoperative Diagnosis of Lymph Node Metastasis in Perihilar Cholangiocarcinoma.|2022|Hosokawa I,Togasaki K,Ohtsuka M,|

Impact of Body Mass Index and Sarcopenia on Short- and Long-Term Outcomes After Esophag...
https://doi.org/10.1245/s10434-022-11944-z 10.1097/SLA.0b013e31821111b5 10.1093/annonc/mdx810 10.1007/s00432-014-1878-x 10.1038/bjc.2013.666 10.1097/MD.0000000000004204 10.1007/s11605-014-2686-y 10.1111/1759-7714.12340 10.1159/000453044 10.1245/s10434-013-3073-8 10.1097/SLA.0000000000002252 10.21873/anticanres.14060 10.1093/dote/doy104 10.1016/j.ejso.2016.11.015 10.1038/s41598-017-14147-9 10.1097/EDE.0b013e3181577654 10.1245/s10434-017-6077-y 10.1016/j.jtcvs.2018.06.098 10.1007/s10047-019-01108-4 10.1111/codi.12805 10.7570/jomes.2019.28.1.40 10.1097/EJA.0000000000000118 10.1016/j.surg.2013.12.001 10.1016/j.athoracsur.2016.04.005 10.1007/s10388-019-00670-3 10.1097/SLA.0000000000002555 10.1016/S1470-2045(08)70153-0 10.1016/j.clnu.2015.05.011 10.1016/j.cell.2011.02.013 10.1016/j.cell.2010.01.025 10.1093/ajcn/80.1.193 10.1128/mBio.01032-13 10.1093/eurheartj/ehq448 10.1016/j.ccell.2014.09.003 10.1016/j.clnu.2009.12.011 10.1016/j.ebiom.2019.10.034 10.1093/jnci/dju124 10.1016/j.amjmed.2007.05.011 10.1510/icvts.2010.256677 10.1212/WNL.0b013e318266fad1 10.1161/STROKEAHA.110.593434 10.1038/ijo.2011.187 10.1016/j.clnu.2009.12.004 10.1093/ageing/afy169 10.1002/jcsm.12221
Annals of Surgical Oncology; Kim GW, Nam JS et. al.

May 28th, 2022 - The effects of specific body mass index (BMI) category and sarcopenia within each BMI category on outcomes in patients undergoing esophageal surgery with esophageal squamous cell carcinoma have not been thoroughly examined. This study included 1141 patients. Sarcopenia was determined with a total psoas muscle cross-sectional area at the level of the third lumbar vertebra in computed tomography....

68Ga-DOTA-FAPI-04 PET/CT Imaging of Tracheal Mucoepidermoid Carcinoma.
https://doi.org/10.1097/RLU.0000000000004293
Clinical Nuclear Medicine; Peng D, Chen Q et. al.

May 28th, 2022 - A 23-year-old woman presented with a dry cough and dyspnea. Contrast-enhanced CT revealed an intratracheal space-occupying lesion with continuous homogeneous enhancement and airway stenosis. The patient then underwent 68Ga-DOTA-FAPI-04 PET/CT, which showed increased uptake of FAPI-04 by the lesion. Postoperative pathology confirmed the lesion as tracheal mucoepidermoid carcinoma. This case repo...

Diffuse Bone Marrow Involvement of Multiple Myeloma on 18FPSMA-1007 PET/CT: Is There a ...
https://doi.org/10.1097/RLU.0000000000004286
Clinical Nuclear Medicine; Michalski K, Jilg CA et. al.

May 28th, 2022 - A 71-year-old man presented with chronic anemia (hemoglobin 7.3 g/dL). Further serum analyses showed elevated prostate-specific antigen (13 ng/mL), suggestive of prostate cancer. However, ultrasound-guided transrectal sextant biopsy did not find any evidence of prostate cancer. In order to improve guidance of intended repeated biopsy, [18F]prostate-specific membrane antigen (PSMA) 1007 PET/CT w...