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About 1,680,508 results

Germline Variants Identified in Patients with Early-onset Renal Cell Carcinoma Referred for Germline Genetic Testing
https://pubmed.ncbi.nlm.nih.gov/34654685/
European Urology Oncology; Truong H

Oct 12th, 2021 - Despite guidelines recommending genetic counseling for patients with early-onset renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations and clinical associations in patients with early-onset RCC are lacking.

Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants
https://www.biorxiv.org/content/10.1101/2021.07.19.452771v1
BioRxiv Tada T, Zhou H et. al.

Jul 19th, 2021 - The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible decreases in vaccine efficacy. Here, neutralizing antibody titers elicited by mRNA-based and an adenoviral vector-based vaccine against variant pseudotyped viruses were compared.

DSHS Statement on Monkeypox Investigation
https://www.dshs.texas.gov/news/releases/2021/20210716.aspx
Texas Health and Human Services

Jul 16th, 2021 - The Texas Department of State Health Services is working with Dallas County Health and Human Services and the CDC to investigate a single case of monkeypox virus infection in a Dallas County resident who recently returned from Nigeria. The patient is isolated in the hospital, and the public health investigation has identified a few people who may have been exposed in Dallas and are monitoring t...

CDC and Texas Confirm Monkeypox In U.S. Traveler
https://www.cdc.gov/media/releases/2021/s0716-confirm-monkeypox.html
Centers for Disease Control and Prevention (CDC)

Jul 16th, 2021 - The Centers for Disease Control and Prevention (CDC) and the Texas Department of State Health Services confirmed on July 15 a case of human monkeypox in a U.S. resident who recently traveled from Nigeria to the United States. The person is currently hospitalized in Dallas. CDC is working with the airline and state and local health officials to contact airline passengers and others who may have ...

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report
https://www.medrxiv.org/content/10.1101/2021.10.10.21264827v1.full.pdf
Medrxiv Atmar RL, .

Oct 13th, 2021 - Background: While Coronavirus disease 2019 (Covid-19) vaccines are highly effective, breakthrough infections are occurring. Booster vaccinations have recently received emergency use authorization (EUA) for certain populations but are restricted to homologous mRNA vaccines. We evaluated homologous and heterologous booster vaccination in persons who had received an EUA Covid-19 vaccine regimen.

Continuous-Release Anti-VEGF Device for AMD Wins FDA Approval
https://www.medpagetoday.com/ophthalmology/generalophthalmology/95225

Oct 23rd, 2021 - The FDA has approved a first-of-its kind continuous delivery system for anti-VEGF therapy for neovascular (wet) age-related macular degeneration (AMD). The Susvimo ocular implant continuously releases 100 mg/mL of ranibizumab directly to the retina over 6 months. Initial implantation and refill can be performed during an office visit with an ophthalmologist. In contrast, conventional intravitre...

Implantable Cardioverter-Defibrillator Therapies and Pulmonary Valve Replacement for Te...
https://doi.org/10.1016/j.jacep.2021.03.014
JACC. Clinical Electrophysiology; Moore JP

Oct 23rd, 2021 - Implantable Cardioverter-Defibrillator Therapies and Pulmonary Valve Replacement for Tetralogy of Fallot.|2021|Moore JP,|

Parkinsonism and cerebrospinal fluid disorders.
https://doi.org/10.1016/j.jns.2021.120019
Journal of the Neurological Sciences; Youn J, Todisco M et. al.

Oct 23rd, 2021 - Although various motor manifestations can be seen in patients with cerebrospinal fluid (CSF) disorders, such as hydrocephalus or intracranial hypotension, the clinical presentation with parkinsonism is not clearly elucidated. We searched the literature for studies describing the occurrence of parkinsonism in subjects with normal pressure hydrocephalus (NPH), obstructive hydrocephalus, and intra...

Right Ventricular-Pulmonary Arterial Coupling in Patients With HF Secondary MR: Analysi...
https://doi.org/10.1016/j.jcin.2021.07.047
JACC. Cardiovascular Interventions; Brener MI, Grayburn P et. al.

Oct 23rd, 2021 - The aim of this study was to determine the prognostic impact of right ventricular (RV)-pulmonary arterial (PA) coupling in patients with heart failure (HF) with severe secondary mitral regurgitation (SMR) enrolled in the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation) trial. RV contractile function ...

Impact of Transcatheter Mitral Valve Repair on Preprocedural and Postprocedural Hospita...
https://doi.org/10.1016/j.jcin.2021.08.007
JACC. Cardiovascular Interventions; Czarnecki A, Han L et. al.

Oct 23rd, 2021 - The objective of this study was to determine the effect of transcatheter mitral valve repair (TMVr) on hospitalization rates by assessing pre- and postprocedural hospitalization patterns. TMVr has emerged as the treatment of choice for selected patients with mitral regurgitation, but the impact of these procedures on hospital utilization remains unclear. All patients who underwent TMVr in Ontar...

Vestibular functions in patients with idiopathic sudden sensorineural hearing loss and ...
https://doi.org/10.1016/j.anl.2021.09.009
Auris, Nasus, Larynx; Kizkapan DB, Karlidag T et. al.

Oct 23rd, 2021 - Because of the anatomically close relationship between the cochlea and the vestibular organs, cochlear function disorders may be accompanied by vestibular disorders. This study aimed to evaluate vestibular functions in patients with idiopathic sudden sensorineural hearing loss using VEMP, caloric test, and VNG test battery and its relation to prognosis. For this study, 42 patients aged 18-55 ye...

Functional outcomes after submandibular gland-sparing neck dissection in patients with ...
https://doi.org/10.1016/j.ijom.2021.09.009
International Journal of Oral and Maxillofacial Surgery; Gu H, Xuan G et. al.

Oct 23rd, 2021 - The feasibility of submandibular gland (SMG) preservation during neck dissection has been described. The aim of this study was to analyse the functional outcomes in patients undergoing SMG preservation during neck dissection for cT1-2N0 oral squamous cell carcinoma. Consecutive patients were divided into two groups based on the management of the SMG, and underwent a saliva flow test before surg...

Differential impact of physical distancing strategies on social contacts relevant for t...
https://doi.org/10.1136/bmjopen-2021-050651
BMJ Open; Del Fava E, Cimentada J et. al.

Oct 23rd, 2021 - We investigate changes in social contact patterns following the gradual introduction of non-pharmaceutical interventions and their implications for infection transmission in the early phase of the pandemic. We conducted an online survey based on targeted Facebook advertising campaigns across eight countries (Belgium, France, Germany, Italy, the Netherlands, Spain, UK and USA), achieving a sampl...

Leveraging immune memory against measles virus as an antitumor strategy in a preclinica...
https://doi.org/10.1136/jitc-2020-002170
Journal for Immunotherapy of Cancer; Leb-Reichl VM, Kienzl M et. al.

Oct 23rd, 2021 - Viral antigens are among the strongest elicitors of immune responses. A significant proportion of the human population already carries pre-existing immunity against several childhood viruses, which could potentially be leveraged to fight cancer. We sought to provide proof of concept in mouse models that a pre-existing measles virus (MeV) immunity can be redirected to inhibit tumor growth by dir...

Impact of the SARS-CoV-2 pandemic on access to contraception and pregnancy intentions: ...
https://doi.org/10.1136/bmjsrh-2021-201164
BMJ Sexual & Reproductive Health; Balachandren N, Barrett G et. al.

Oct 23rd, 2021 - Evaluate the impact of the COVID-19 pandemic on access to contraception and pregnancy intentions. Nationwide prospective cohort study. United Kingdom. Women in the UK who were pregnant between 24 May and 31 December 2020. Access to contraception and level of pregnancy intentions, using the London Measure of Unplanned Pregnancy (LMUP) in women whose last menstrual period was before or after 1 Ap...

Effect of Levetiracetam Use Duration on Overall Survival of Isocitrate Dehydrogenase Wi...
https://doi.org/10.1212/WNL.0000000000013005
Neurology Pallud J, Huberfeld G et. al.

Oct 23rd, 2021 - The association between Levetiracetam and survival of Isocitrate Dehydrogenase (IDH) wildtype glioblastomas is controversial. We investigated whether the duration of Levetiracetam use during the standard chemoradiation protocol impacts overall survival of IDH-wildtype glioblastoma patients. Observational single-institution cohort study (2010-2018). Inclusion criteria were: 1) patients ≥18 years...

Clinical Reasoning: Progressive Proximal Weakness in a 61-Year-Old Male.
https://doi.org/10.1212/WNL.0000000000013000
Neurology Yu M, Bitar M et. al.

Oct 23rd, 2021 - A 61-year-old man presents with painless progressive weakness and was found to have myopathy both clinically and on diagnostic workup.The etiology of his myopathy is the first reported case of anti-SRP myopathy and sarcoidosis overlap syndrome. The high titer anti-SRP antibody and phenotype support the diagnosis of an overlap syndrome, defined as multiple distinct autoimmune diseases occurring ...

GGC Repeat Expansion of NOTCH2NLC in Taiwanese Patients With Inherited Neuropathies.
https://doi.org/10.1212/WNL.0000000000013008
Neurology Liao YC, Chang FP et. al.

Oct 23rd, 2021 - The GGC repeat expansion in the 5' untranslated region of NOTCH2NLC was recently identified as the cause of neuronal intranuclear inclusion disease (NIID), which may manifest with peripheral neuropathy. The aim of this study is to investigate its contribution to inherited neuropathy. This cohort study screened patients with molecularly undiagnosed Charcot-Marie-Tooth disease (CMT) and healthy c...

NOTCH2NLC-related disorders: the widening spectrum and genotype-phenotype correlation.
https://doi.org/10.1136/jmedgenet-2021-107883
Journal of Medical Genetics; Fan Y, Xu Y et. al.

Oct 23rd, 2021 - GGC repeat expansion in the 5' untranslated region of NOTCH2NLC is the most common causative factor in neuronal intranuclear inclusion disease (NIID) in Asians. Such expanded GGC repeats have been identified in patients with leukoencephalopathy, essential tremor (ET), multiple system atrophy, Parkinson's disease (PD), amyotrophic lateral sclerosis and oculopharyngodistal myopathy (OPDM). Herein...

Acceptability of hygiene, face covering and social distancing interventions to prevent ...
https://doi.org/10.1136/thoraxjnl-2021-217981
Thorax Hurst JR, Cumella A et. al.

Oct 23rd, 2021 - Interventions to prevent the spread of SARS-CoV-2 have been associated with substantial reductions in exacerbations of airways diseases, likely through reduced transmission of other respiratory viruses. We surveyed 4442 people with airways disease (asthma=3627, bronchiectasis=258, chronic obstructive pulmonary disease=557) to gauge attitudes and intentions towards continuing such measures after...

Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study.
https://doi.org/10.1136/thoraxjnl-2021-217870
Thorax Nathan N, Montagne ME et. al.

Oct 23rd, 2021 - Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients' indirect exposure to inorganic particles, through coresidents' occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5-7) vs 0.5 (0-2), p=0.003 and...

Variation of Patent Ductus Arteriosus Treatment in Very Low Birth Weight Infants.
https://doi.org/10.1542/peds.2021-052874
Pediatrics Runte KE, Flyer JN et. al.

Oct 23rd, 2021 - Patent ductus arteriosus (PDA) treatment is common among very low birth weight (VLBW) infants. Given limitations in evidence, controversy exists regarding treatment risks and benefits. In this study, we describe PDA treatment trends and variation in a large, US, multicenter VLBW infant cohort. Data were collected through Vermont Oxford Network on 291 292 VLBW infants born 2012-2019 at 806 US NI...

New treatment algorithm for keratoconus and cataract: small-aperture IOL insertion with...
https://doi.org/10.1097/j.jcrs.0000000000000642
Journal of Cataract and Refractive Surgery; Northey LC, Holland SP et. al.

Oct 23rd, 2021 - To describe a new treatment algorithm aimed at optimizing refractive outcomes for patients with keratoconus and cataract. Private practice in Sydney, Australia. Retrospective case series. This procedural approach involves cataract extraction with small-aperture intraocular lens (IOL) insertion, IC-8 IOL (AcuFocus, Inc.), followed by topography-guided photorefractive keratectomy (T-PRK) with sim...

Accuracy of IOL power calculation formulas in Marfan lens subluxation patients with in-...
https://doi.org/10.1097/j.jcrs.0000000000000649
Journal of Cataract and Refractive Surgery; Zhang M, Chen T et. al.

Oct 23rd, 2021 - To investigate the accuracy of intraocular lens (IOL) formulas for the prediction of postoperative refraction in lens subluxation in Marfan syndrome. Eye and ENT Hospital of Fudan University, Shanghai, China. Consecutive retrospective clinical observational case series. 60 eligible eyes with lens subluxation from 39 young patients with Marfan syndrome (8.53 ± 4.38 years) underwent phacoemulsifi...

Nuclear cataract, moderate oblique corneal astigmatism, and glaucoma in a highly myopic...
https://doi.org/10.1097/j.jcrs.0000000000000835
Journal of Cataract and Refractive Surgery; Menapace R

Oct 23rd, 2021 - A 65-year-old woman had undergone bilateral foldable iris-fixated phakic intraocular lens (pIOL) implantation in 2008 to correct for high myopia of -10 diopters (D). 12 years later, she presented with nuclear and subcortical cataract in her right eye. The Artiflex pIOL (Figure 1JOURNAL/jcrs/04.03/02158034-202111000-00021/figure1/v/2021-10-20T185516Z/r/image-tiff) was well centered and fixed to ...

Intracellular delivery of protein drugs with an autonomously lysing bacterial system re...
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Nature Communications; Raman V, Van Dessel N et. al.

Oct 23rd, 2021 - Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell membranes. Here we report the development of a Salmonella-based intracellular delivery system to address this challenge. We engineer genetic circuits that (1) activate the regulator flhDC to drive invasion and (2) induce lysis to release proteins into tumor cells. Released protein drugs diffuse from Sa...

The Characteristics of Power Spectral Density in Bipolar Disorder at the Resting State.
https://doi.org/10.1177/15500594211050487
Clinical EEG and Neuroscience; Sunaga M, Takei Y et. al.

Oct 23rd, 2021 - Bipolar disorder (BD) is a common psychiatric disorder, but its pathophysiology is not fully elucidated. The current study focused on its electrophysiological characteristics, especially power spectral density (PSD). Resting state with eyes opened magnetoencephalography data were collected from 21 patients with BD and 22 healthy controls. The whole brain's PSD was calculated from source reconst...

Association between toxic organochlorine levels in human serum and systemic lupus eryth...
https://doi.org/10.1177/09612033211051947
Lupus Helmy MA, Saad-Hussein A et. al.

Oct 23rd, 2021 - Organochlorines (OCs) are groups of highly toxic pesticides with known immunotoxicity. The present work aimed to study the potential association between serum residues of OCs and the risk of developing systemic lupus erythematosus (SLE) as well as correlating to the clinical-laboratory manifestations in a sample of Egyptian SLE patients. A cross-sectional study was conducted on 132 patients env...

Esophageal cancer mutational signatures around the world.
https://doi.org/10.1038/s41588-021-00958-0 10.1016/j.cell.2013.03.002 10.1038/nature12477 10.1016/j.cell.2019.03.001 10.1038/s41588-021-00928-6 10.1038/s41586-020-1943-3 10.1136/gutjnl-2019-320462 10.1038/s41586-020-2080-8 10.1158/2159-8290.CD-20-1656 10.1053/j.gastro.2017.08.023 10.1053/j.gastro.2018.12.024 10.1038/ncomms6135 10.1038/s41588-020-0692-4 10.1093/aje/kwaa234 10.1038/s41586-019-1672-7 10.1126/science.aao3130
Nature Genetics; Giannakis M, Peters U

Oct 23rd, 2021 - Esophageal cancer mutational signatures around the world.|2021|Giannakis M,Peters U,|

Accurately Controlled Delivery of Temozolomide by Biocompatible UiO-66-NH2 Through Ultr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517532
International Journal of Nanomedicine; Wan Z, Li C et. al.

Oct 23rd, 2021 - Glioma is the most common and malignant primary brain tumour in adults and has a dismal prognosis. Temozolomide (TMZ) is the only clinical first-line chemotherapy drug for malignant glioma up to present. Due to poor aqueous solubility and toxic effects, TMZ is still inefficient and limited for clinical glioma treatment. UiO-66-NH2 nanoparticle is a zirconium-based framework, constructed by Zr a...

Sodium Butyrate Alleviates Intestinal Inflammation in Mice with Necrotizing Enterocolitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526205
Mediators of Inflammation; Sun Q, Ji YC et. al.

Oct 23rd, 2021 - To determine the role of sodium butyrate in intestinal inflammation via regulation of high-mobility group box-1 (HMGB1), we analyzed the potential mechanism in necrotizing enterocolitis (NEC) in a neonatal mouse model. A NEC model was created with hypoxia and cold exposure and artificial overfeeding. C57BL/6 neonatal mice were randomized into three groups: the control, untreated NEC, and sodium...

Intraarterial Lidocaine Administration for Pain Control by Water-in-Oil Technique in Tr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502067
Journal of Hepatocellular Carcinoma; Wang LZ, Hu XX et. al.

Oct 23rd, 2021 - To investigate the sustained release of lidocaine from a lidocaine-epirubicin-lipiodol emulsion created by water-in-oil (W/O) technique in vivo and evaluate the efficacy and safety of intraarterial lidocaine administration for intra- and postoperative pain control in transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). The in vivo concentrations of lidocaine were determine...

Lenvatinib Combined with Anti-PD-1 Antibodies Plus Transcatheter Arterial Chemoemboliza...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502053
Journal of Hepatocellular Carcinoma; Wu JY, Yin ZY et. al.

Oct 23rd, 2021 - Lenvatinib (LEN) combined with anti-PD-1 antibodies (PD-1) exerted promising effects on unresectable hepatocellular carcinoma (uHCC). We assessed the safety and clinical efficacy of triple therapy [LEN+PD-1+transcatheter arterial chemoembolization (TACE)] in uHCC. uHCC patients with an ECOG PS score of 0-1 and Child-Pugh class A who underwent triple therapy were included. The primary endpoint w...

Predictive factors associated with induction-related death in acute myeloid leukemia in...
https://doi.org/10.1007/s00277-021-04687-6 10.1182/blood.2019001239 10.1080/10428194.2020.1827252 10.1002/cncr.29319 10.1182/bloodadvances.2020001728 10.1080/10428190600627055 10.1016/j.leukres.2017.07.005 10.1016/S0140-6736(10)62105-8 10.1111/bjh.14631 10.1182/bloodadvances.2019001419 10.1016/j.jbi.2008.08.010 10.1002/cncr.31296 10.1182/blood-2016-08-733196 10.1016/0021-9681(87)90171-8 10.1038/sj.bmt.1705727 10.1016/S0167-7152(96)00128-9 10.1371/journal.pone.0176231 10.1182/bloodadvances.2020003806 10.3389/fmicb.2020.01422 10.1371/journal.pone.0210991 10.1016/j.leukres.2015.02.003 10.1097/MD.0000000000004182 10.1002/cncr.26273 10.1080/10428190701809172 10.1007/s11899-007-0014-2 10.1200/JCO.18.00374 10.1007/s11912-017-0574-9 10.1182/blood-2019-123435 10.1002/cncr.21723 10.3324/haematol.13309 10.1200/JCO.2011.35.7525 10.1016/j.clml.2019.12.015
Annals of Hematology; Mendes FR, da Silva WF et. al.

Oct 23rd, 2021 - Despite advances in supportive measures, acute myeloid leukemia (AML) remission induction still has a high mortality rate in real-world studies as compared to prospective reports. We analyzed data from 206 AML adult patients treated with conventional chemotherapy. The primary endpoint was the 60-day mortality rate, aiming to find risk factors and to examine the role of anti-infection prophylaxi...

Psychiatric, Substance Use, and Structural Disparities Between Gay and Bisexual Men wit...
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Archives of Sexual Behavior; Batchelder AW, Fitch C et. al.

Oct 23rd, 2021 - Sexual minority men disproportionately experience childhood sexual abuse (CSA) compared to heterosexual men, resulting in greater risk of psychiatric and substance use diagnoses, sexual risk taking, and HIV acquisition later in life. However, little is known about psychiatric and substance use disparities between gay and bisexual men who have experienced CSA. We recruited a purposive convenienc...

Thymoma-associated autoimmune enteropathy with colonic stricture: a diagnostic and hist...
https://doi.org/10.1007/s12328-021-01531-2 10.1038/cmi.2010.74 10.3109/08916930903555935 10.1080/08880010050211420 10.1007/s00428-017-2243-7 10.1016/j.cgh.2007.05.013 10.1056/NEJMcpc1406663 10.1093/ajcp/112.6.810 10.1007/s10620-005-2666-x 10.1007/s00428-018-2304-6 10.1007/s11894-012-0276-2 10.14309/crj.0000000000000520 10.1111/j.1572-0241.2004.40039.x 10.1136/gut.50.2.206
Clinical Journal of Gastroenterology; Pieplenbosch B, de Leijer JH et. al.

Oct 23rd, 2021 - Thymoma-associated autoimmune enteropathy is a rare paraneoplastic syndrome that is characterized by severe chronic diarrhea, malabsorption, and specific histological findings. Because of its rarity, it is difficult to diagnose. We describe an adult patient with protracted diarrhea and weight loss that developed recurrent sepsis and progressive colonic stenosis due to thymoma-associated autoimm...

The effect of immunosuppressive therapy in patients with fibrinoid necrosis lesions in ...
https://doi.org/10.1007/s40620-021-01176-x 10.1056/NEJMra1206793 10.2215/CJN.07420716 10.1093/ndt/gfy338 10.1053/j.ajkd.2019.04.031 10.1016/j.autrev.2015.02.003 10.1159/000445759 10.1053/j.ajkd.2012.06.011 10.1016/j.humpath.2018.01.026 10.1038/ki.2009.243 10.2215/CJN.11521210 10.1016/j.kint.2017.02.003 10.1046/j.1523-1755.2001.059002682.x 10.1111/j.1440-1827.1993.tb02558.x 10.2169/internalmedicine.40.862 10.1159/000065281 10.1590/s0100-879x2004000900012 10.1007/s40620-014-0165-x 10.1053/j.ajkd.2016.11.027 10.1053/ajkd.2002.31399 10.1093/ndt/gfg081 10.2215/CJN.02500317 10.1038/ki.1991.82 10.1038/ki.1990.148
Journal of Nephrology; Guo Y, Shi S et. al.

Oct 23rd, 2021 - Fibrinoid necrosis is considered one of the active pathological lesions in IgA nephropathy. Whether patients with IgA nephropathy with fibrinoid necrosis lesions benefit from immunosuppressive therapy in terms of long-term outcomes remains uncertain. This study aimed to evaluate the response to immunosuppressive therapy in patients with fibrinoid necrosis lesions in a large cohort of patients w...

Altered increase in STAT1 expression and phosphorylation in severe COVID-19.
https://doi.org/10.1002/eji.202149575
European Journal of Immunology; Rincon-Arevalo H, Aue A et. al.

Oct 23rd, 2021 - The interferon pathway, a key antiviral defense mechanism, is being considered as a therapeutic target in COVID-19. Both, substitution of interferon and JAK/STAT inhibition to limit cytokine storms have been proposed. However, little is known about possible abnormalities in STAT signaling in immune cells during SARS-CoV-2 infection. We investigated downstream targets of interferon signaling, in...

The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their...
https://doi.org/10.1113/JP281707
The Journal of Physiology; Wilson AD, Hu J et. al.

Oct 23rd, 2021 - RyR2 mutations can cause type-1 catecholaminergic polymorphic ventricular tachycardia (CPVT1), a lethal, autosomal-dominant arrhythmic disease. However, the changes in RyR2 ion-channel function that result from the many different patient mutations are rarely investigated in detail and often only recombinant RyR2, homozygous for the mutation, are studied. As CPVT1 is a heterozygous disease and t...

Unravelling protein turnover in duchenne muscular dystrophy: One protein at a time.
https://doi.org/10.1113/JP282386
The Journal of Physiology; McKendry J, Phillips SM

Oct 23rd, 2021 - Unravelling protein turnover in duchenne muscular dystrophy: One protein at a time.|2021|McKendry J,Phillips SM,|

OPEN SURGERY FOR IN UTERO REPAIR OF SPINA BIFIDA: MICRONEUROSURGERY VS STANDARD TECHNIQ...
https://doi.org/10.1002/pd.6063
Prenatal Diagnosis; Molina-Giraldo S, Salcedo RZ et. al.

Oct 23rd, 2021 - Prenatal myelomeningocele (MMC) repair has been shown to improve neurological outcomes. It has been suggested that decreases in the hysterotomy diameter during surgery can improve perinatal outcomes without altering neurologic outcomes. The objective of this study is to describe and compare the main maternal and fetal outcomes of fetuses undergoing open surgery for MMC repair, through the diffe...

THE EVALUATION POTENTIAL GLOBAL IMPACT OF THE N501Y MUTATION IN SARS-COV-2 POSITIVE PAT...
https://doi.org/10.1002/jmv.27413
Journal of Medical Virology; Komurcu SZM, Artik Y et. al.

Oct 23rd, 2021 - Rapid and reliable detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations are significant to control the contagion and spread rate of the virus. We aimed to evaluate the N501Y mutation rate in randomly chosen positive patients with polymerase chain reaction (PCR). The evaluation and analysis of the data in terms of public health will contribute to the literature on ...

Is the course of COVID-19 associated with tuberculin skin test diameter? A retrospectiv...
https://doi.org/10.1002/jmv.27414
Journal of Medical Virology; Gulen TA, Bayraktar M et. al.

Oct 23rd, 2021 - The pathogenesis of COVID-19 is still not fully understood. Since SARS-COV-2 has a similar pathogenetic pathway to Mycobacterium tuberculosis, it has been reported that there may be a relationship between BCG vaccination rate and COVID-19 severity. This study investigated the relationship between tuberculin skin test (TST) induration diameter and the clinical course of COVID-19. Of 1963 adult p...

LncRNA PTPRG-AS1 facilitates glycolysis and stemness properties of esophageal squamous ...
https://doi.org/10.1111/jgh.15719
Journal of Gastroenterology and Hepatology; Wu K, Wang Z et. al.

Oct 23rd, 2021 - Esophageal squamous cell carcinoma (ESCC) is the most significant subtype of esophageal cancer featured with high occurrence. Long noncoding RNAs (lncRNAs) have been proved to modulate the biological properties of cancer cells, including cell proliferation, invasion, migration and apoptosis. LncRNA protein tyrosine phosphatase receptor type G-antisense RNA 1 (PTPRG-AS1) has been reported to pla...

Performance evaluation of Elecsys SARS-CoV-2 Antigen immunoassay for diagnostic of COVI...
https://doi.org/10.1002/jmv.27412
Journal of Medical Virology; Montalvo Villalba MC, Sosa Glaria E et. al.

Oct 23rd, 2021 - One of challenge for control and prevention of SARS-CoV-2 infection is the early diagnostic at the point of care. Several tests based on qualitative antigen detection have been developed; one of these is Elecsys SARS-CoV-2 Antigen immunoassay (Roche Diagnostics). In total 523 nasopharyngeal swabs were randomly selected with the aims to evaluate sensitivity, specificity, cross-reactivity, positi...

Applying Deep Learning to Quantify Empty Lacunae in Histologic Sections of Osteonecrosi...
https://doi.org/10.1002/jor.25201
Journal of Orthopaedic Research : Official Publication Of... Lui E, Maruyama M et. al.

Oct 23rd, 2021 - Osteonecrosis of the femoral head (ONFH) is a disease in which inadequate blood supply to the subchondral bone causes death of cells in the bone marrow. Decalcified histology and assessment of the percentage of empty lacunae are used to quantify the severity of ONFH. However, the current clinical practice of manually counting cells is a tedious and inefficient process. We utilized the power of ...

Update of recent findings in genetic hair disorders.
https://doi.org/10.1111/1346-8138.16204
The Journal of Dermatology; Hayashi R, Shimomura Y

Oct 23rd, 2021 - Genetic hair disorders, although unusual, are not very rare, and dermatologists often have opportunities to see patients. Significant advances in molecular genetics have led to identifying many causative genes for genetic hair disorders, including the recently identified causative genes, such as LSS and C3ORF52. Many patients have been detected with autosomal recessive woolly hair/hypotrichosis...

Immunoglobulin A nephropathy in pediatrics: an up-to-date.
https://doi.org/10.1111/nep.13987
Nephrology (Carlton, Vic.); Paranhos RM, de Souza Figueiredo GA et. al.

Oct 23rd, 2021 - Immunoglobulin A nephropathy is the main cause of glomerulonephritis globally and an important etiology of end-stage renal disease in children. It has been considered an autoimmune disease that can lead to the production of autoantibodies against abnormal IgA1 and formation of immune complexes. These autoantibodies and immune complexes deposit in the glomeruli, resulting in renal injury. At the...

The lectin pathway does not contribute to glomerular injury in the nephrotoxic nephriti...
https://doi.org/10.1111/nep.13988
Nephrology (Carlton, Vic.); Freeley SJ, Tham E et. al.

Oct 23rd, 2021 - Rapidly progressive crescentic glomerulonephritis occurs in a number systemic and primary glomerular diseases, including anti-glomerular basement membrane disease, anti-neutrophil cytoplasmic antibody vasculitis, and lupus nephritis. Our understanding of pathogenic mechanisms comes from animal models of disease such as the nephrotoxic nephritis model. The lectin pathway of complement activation...

Pediatric Discoid Lupus Erythematosus: Short report.
https://doi.org/10.1111/dth.15170
Dermatologic Therapy; Hawat T, Ballouz S et. al.

Oct 23rd, 2021 - Pediatric discoid lupus erythematosus is a rare inflammatory skin disorder. This paper aims to review all the available clinical and therapeutic data on reported cases of pediatric discoid lupus erythematosus. A systematic review of the literature was conducted using Pubmed and Embase with no limitation on publication date, sex or nationality. 32 articles were included with 201 cases, a mean ag...

Cachexia index as a potential biomarker for cancer cachexia and a prognostic indicator ...
https://doi.org/10.1002/jcsm.12837
Journal of Cachexia, Sarcopenia and Muscle; Go SI, Park MJ et. al.

Oct 23rd, 2021 - Cancer cachexia is known to adversely affect the clinical course in patients with malignant lymphoma. The cachexia index (CXI) is a potential biomarker of cancer cachexia, and its implications for the prognosis and treatment outcome of lung cancer and aggressive lymphoma has been assessed in previous studies. A total of 267 patients diagnosed with diffuse large B-cell lymphoma who were treated ...

Exercise duration modulates upper and lower respiratory fluid cellularity, antiviral ac...
https://doi.org/10.14814/phy2.15075
Physiological Reports; Elkhatib SK, Alley J et. al.

Oct 23rd, 2021 - Exercise has substantial health benefits, but the effects of exercise on immune status and susceptibility to respiratory infections are less clear. Furthermore, there is limited research examining the effects of prolonged exercise on local respiratory immunity and antiviral activity. To assess the upper respiratory tract in response to exercise, we collected nasal lavage fluid (NALF) from human...

A modern approach to dyslipidemia.
https://doi.org/10.1210/endrev/bnab037
Endocrine Reviews; Berberich AJ, Hegele RA

Oct 23rd, 2021 - Lipid disorders involving derangements in serum cholesterol, triglycerides or both are commonly encountered in clinical practice and often have implications for cardiovascular risk and overall health. Recent advances in knowledge, recommendations and treatment options have necessitated an updated approach to these disorders. Older classification schemes have outlived their usefulness yielding t...

Dominant Clade-featured SARS-CoV-2 Co-occurring Mutations Reveals Plausible Epistasis: ...
https://doi.org/10.1002/jmv.27416
Journal of Medical Virology; Rubayet Ul Alam ASM, Islam OK et. al.

Oct 23rd, 2021 - SARS-CoV-2 is evolved into eight fundamental clades where four (G, GH, GR, and GV) are globally prevalent in 2020. To explain plausible epistatic effects of the signature co-occurring mutations of these circulating clades on viral replication and transmission fitness, we proposed a hypothetical model using in silico approach. Molecular docking and dynamics analyses showed the higher infectiousn...

circCORO1C promotes the proliferation and metastasis of hepatocellular carcinoma by enh...
https://doi.org/10.1002/jcla.24003
Journal of Clinical Laboratory Analysis; Wu F, Sun G et. al.

Oct 23rd, 2021 - Circular RNA (circRNA) affects the occurrence and development of human cancers, but the specific mechanism of hepatocellular carcinoma (HCC) has not yet been fully understood. CircRNAs were determined by human circRNA array analysis and quantitative reverse transcription polymerase chain reaction (qRT-PCR). Cell viability, migration, invasion, and other indicators were used for cell function an...

High expression of DHX9 promotes the growth and metastasis of hepatocellular carcinoma.
https://doi.org/10.1002/jcla.24052
Journal of Clinical Laboratory Analysis; Shi F, Cao S et. al.

Oct 23rd, 2021 - DHX9, an NTP-dependent RNA helicase, is closely associated with the proliferation and metastasis of some tumor cells and the prognosis of patients, but its role in hepatocellular carcinoma (HCC) is not well-known. This study was performed to explore the expression and role of DHX9 in HCC. The expression of DHX9 in HCC tissues and cell lines was detected by TCGA database, qPCR, western blotting,...

Double immune reconstitution therapy: cladribine after alemtuzumab in treatment of mult...
https://doi.org/10.1111/ene.15153
European Journal of Neurology; Adamec I, Jovanović I et. al.

Oct 23rd, 2021 - Alemtuzumab, a monoclonal anti-CD52 antibody, and cladribine, a purine nucleoside analogue, are used for treatment of highly active relapsing remitting multiple sclerosis (MS). Both are administered as two short yearly courses but possess the ability to induce long-term remission labeling them as immune reconstitution therapies. Although disease activity after alemtuzumab administration is rare...

Development and Validation of an Online Calculator to Predict Early Recurrence and Long...
https://doi.org/10.1002/jhbp.1058
Journal of Hepato-biliary-pancreatic Sciences; Xu S, Zhang XP et. al.

Oct 23rd, 2021 - Distal Cholangiocarcinoma (DCC) is a malignancy associated with a short survival time. In this study, we aimed to create an online nomogram calculator to predict early recurrence and long-term survival in patients with DCC after pancreaticoduodenectomy. A total of 486 patients with DCC were included. An online nomogram calculator was developed and validated in training, internal validation and ...

Is Technical Expertise Necessary to Assess Technical Expertise? Let's Ask the Kids.
https://doi.org/10.1089/lap.2021.0321
Journal of Laparoendoscopic & Advanced Surgical Technique... Nair D, Wells JM et. al.

Oct 23rd, 2021 - Background: Simulation has an increasing role in surgical training; however, using validated tools such as the Objective Structured Assessment of Technical Skills (OSATS) is time-consuming, which may be a potential barrier to simulation-based training. This study tests the hypothesis that assessors with technical expertise are necessary to objectively score a technical task. Methods: Three task...

Health Profile of Preterm Males With Duchenne Muscular Dystrophy.
https://doi.org/10.1177/08830738211047019
Journal of Child Neurology; Soim A, Wallace B et. al.

Oct 23rd, 2021 - In this retrospective cohort study, we characterize the health profile of preterm males with Duchenne muscular dystrophy. Major clinical milestones (ambulation cessation, assisted ventilation use, and onset of left ventricular dysfunction) and corticosteroids use in males with Duchenne muscular dystrophy identified through a population-based surveillance system were analyzed using Kaplan-Meier ...

Recent Advances in Photodynamic Imaging and Therapy in Hepatobiliary Malignancies: Clin...
https://doi.org/10.3390/curroncol28050345
Current Oncology (Toronto, Ont.); Nanashima A, Hiyoshi M et. al.

Oct 23rd, 2021 - The therapeutic and diagnostic modalities of light are well known, and derivative photodynamic reactions with photosensitizers (PSs), specific wavelengths of light exposure and the existence of tissue oxygen have been developed since the 20th century. Photodynamic therapy (PDT) is an effective local treatment for cancer-specific laser ablation in malignancies of some organs, including the bile ...

Pretreatment Neutrophil-to-Lymphocyte Ratio as a Predictive Marker of Response to Atezo...
https://doi.org/10.3390/curroncol28050352
Current Oncology (Toronto, Ont.); Eso Y, Takeda H et. al.

Oct 23rd, 2021 - Combination therapy with anti-programmed death-ligand 1 monoclonal antibody atezolizumab plus anti-vascular endothelial growth factor agent bevacizumab (Atezo/Bev) was approved in 2020 as a first-line treatment for unresectable hepatocellular carcinoma (HCC). Atezo/Bev therapy is relatively well tolerated; however, factors that can predict its response have not yet been reported. Thus, we aimed...

Total Colectomy as a Part of Ultra-Radical Surgery for Ovarian Cancer-Short- and Long-T...
https://doi.org/10.3390/curroncol28050358
Current Oncology (Toronto, Ont.); Szubert S, Skowyra A et. al.

Oct 23rd, 2021 - (1) Background: The aim of this study was to assess the outcomes for patients who underwent total colectomy (TC) as a part of surgery for ovarian cancer (OC). (2) Methods: We performed a retrospective analysis of 1636 OC patients. Residual disease (RD) was reported using Sugarbaker's completeness of cytoreduction score. (3) Results: Forty-two patients underwent TC during primary debulking surge...

Longitudinal Stability of Intellectual Functioning in Autism Spectrum Disorder: From Ag...
https://doi.org/10.1007/s10803-021-05227-x 10.1109/TAC.1974.1100705 10.1080/09297040500473714 10.1016/j.neuroimage.2006.08.032 10.1111/jcpp.12178 10.1093/brain/awr263 10.1037/neu0000418 10.1176/appi.ajp.2017.16101115 10.1007/s10803-014-2250-3 10.1352/1944-7558-116.5.331 10.1080/09297040600630288 10.1016/j.rasd.2016.11.013 10.1073/pnas.1718793115 10.1093/arclin/acw079 10.1037/pas0000358 10.1186/s13229-017-0145-9 10.1017/S0033291710000991 10.1146/annurev-psych-120710-100353 10.1023/a:1022903913547 10.1080/13803395.2013.827156 10.1002/aur.69 10.1097/00004583-199105000-00003 10.5962/bhl.title.61710 10.1080/09297049.2015.1056131 10.1093/cercor/bhy330 10.1016/j.neuron.2012.06.022 10.1177/0956797614567339 10.1093/arclin/acw064 10.1111/j.1469-7610.2004.00215.x 10.1016/j.jaac.2013.02.017 10.1111/jcpp.12115 10.1007/s10803-012-1719-1 10.1007/s10803-014-2080-3 10.2466/03.15.PR0.116k24w8 10.1111/1469-7610.00092 10.1177/0022219410392044 10.3390/jintelligence6040045 10.1001/jamanetworkopen.2018.4777 10.1007/s10803-017-3213-2 10.1002/ajmg.a.31465 10.2307/2529876 10.1080/87565641003696833 10.1080/01621459.1989.10478761 10.1002/aur.1427 10.1002/ajmg.c.31440 10.1177/1362361320919246 10.1007/BF02172145 10.1080/13803390802169059 10.1016/j.cpr.2013.11.002 10.1016/j.pscychresns.2018.06.013 10.33588/rn.66S01.2018011 10.1177/1362361303007001006 10.1007/s10882-011-9231-7 10.1002/aur.1366 10.1002/aur.1909 10.1002/aur.2084 10.1111/j.1600-0447.1998.tb09970.x 10.1002/aur.1910 10.1111/jcpp.13180 10.1002/aur.1265 10.3390/jintelligence5020018 10.1037/dev0000162 10.1177/1073191117721742 10.1037/pag000028 10.1016/j.jaac.2019.11.020 10.1002/aur.1884 10.1037/a0024935 10.1111/jir.12423 10.1002/aur.2081 10.1111/desc.12401 10.1016/j.neuropsychologia.2013.11.008 10.1186/s13229-015-0001-8 10.1016/j.ridd.2014.02.013 10.1017/s0954579498001667 10.1111/j.2041-210X.2011.00125.x 10.1371/journal.pone.0049172 10.1093/brain/awu083
Journal of Autism and Developmental Disorders; Prigge MBD, Bigler ED et. al.

Oct 23rd, 2021 - Intelligence (IQ) scores are used in educational and vocational planning for individuals with autism spectrum disorder (ASD) yet little is known about the stability of IQ throughout development. We examined longitudinal age-related IQ stability in 119 individuals with ASD (3-36 years of age at first visit) and 128 typically developing controls. Intelligence measures were collected over a 20-yea...

Emerging Epigenetic Therapies for Brain Tumors.
https://doi.org/10.1007/s12017-021-08691-x 10.1177/1533033820960748 10.1371/journal.pone.0080865 10.1038/nature02871 10.1186/s40478-020-00942-5 10.18632/oncotarget.1408 10.1016/j.neuint.2014.06.002 10.1038/s41392-019-0095-0 10.1371/journal.pone.0025114 10.1093/nar/gkv703 10.1002/pmic.201800479 10.3390/cancers8030031 10.1038/nrg3074 10.18632/oncotarget.15206 10.1093/jnen/nlaa059 10.1016/j.semcancer.2008.01.008 10.1186/s40364-019-0174-y 10.1038/s41416-020-0814-x 10.1182/blood-2013-10-533604 10.1016/j.mam.2013.01.005 10.1016/j.canlet.2012.04.008 10.1016/j.gendis.2016.04.007 10.3389/fphar.2017.00495 10.1186/s40478-015-0206-2 10.1038/nn.4190 10.1200/JCO.19.03327 10.1158/1078-0432.CCR-10-0395 10.18632/oncotarget.20741 10.1038/nm.4293 10.15430/JCP.2019.24.2.79 10.1007/s12035-012-8349-7 10.1016/j.semcancer.2009.02.005 10.1038/s41572-019-0063-6 10.3389/fendo.2018.00402 10.1093/neuonc/noz150 10.1186/s40478-014-0180-0 10.1186/s13046-019-1180-5 10.1093/carcin/bgt182 10.1126/science.1236062 10.3389/fonc.2018.00448 10.1128/MCB.00332-09 10.1038/nature13387 10.1007/s10555-009-9188-5 10.1093/neuonc/nos281 10.1371/journal.pone.0024248 10.1001/jama.2017.18718 10.1007/s00401-011-0922-z 10.1038/nature10866 10.18632/oncotarget.362 10.3389/fonc.2012.00205 10.1093/neuonc/nov292 10.22034/APJCP.2018.19.9.2613 10.1093/neuonc/now016 10.4103/2230-973X.167646 10.1093/neuros/nyx262
Neuromolecular Medicine; Kukreja L, Li CJ et. al.

Oct 23rd, 2021 - Malignant brain tumors are among the most intractable cancers, including malignancies such as glioblastoma, diffuse midline glioma, medulloblastoma, and ependymoma. Unfortunately, treatment options for these brain tumors have been inadequate and complex, leading to poor prognoses and creating a need for new treatment modalities. Aberrant epigenetics define these types of tumors, with underlying...

Immune Checkpoint Inhibitors for Advanced Cutaneous Squamous Cell Carcinoma: A Systemat...
https://doi.org/10.1007/s11523-021-00844-z 10.1016/j.jaad.2012.11.037 10.1111/j.1365-2133.2012.10830.x 10.1016/j.jaad.2017.08.059 10.1136/bmj.f6153 10.1016/0190-9622(92)70144-5 10.1016/S0360-3016(01)01656-X 10.1016/j.jaad.2017.07.048 10.1200/JCO.2010.34.1735 10.1002/cncr.31346 10.1097/DSS.0000000000000799 10.1097/COC.0000000000000088 10.1200/JCO.2019.37.15_suppl.e21033 10.1158/1535-7163.MCT-16-0665 10.1097/EDE.0b013e3181fe7825 10.1136/bmj.315.7109.629 10.1016/S0895-4356(01)00377-8 10.1056/NEJMoa1805131 10.1200/JCO.19.03054 10.1200/JCO.19.03357 10.1016/S1470-2045(19)30728-4 10.1136/jitc-2020-000775 10.1200/JCO.2019.37.15_suppl.e21015 10.1016/j.ejca.2020.01.008 10.1007/s11864-016-0408-2 10.1016/j.ejca.2020.07.029 10.3390/cancers13143547 10.1016/j.jgo.2021.02.026 10.1111/cup.13709 10.1186/s13073-017-0424-2 10.1007/s40265-020-01302-2 10.3747/co.27.6015 10.1200/JCO.2020.38.15_suppl.TPS10084 10.1200/JCO.2019.37.15_suppl.TPS9597 10.1093/annonc/mdz394.071 10.1016/j.ejca.2008.10.026 10.1002/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6 10.1136/jitc-2019-000146
Targeted Oncology; Mehta NK, Li AR et. al.

Oct 23rd, 2021 - Results of early trials led to FDA approval of immune checkpoint inhibitors (ICIs) for advanced and recurrent/metastatic (R/M) cutaneous squamous cell carcinoma (CSCC). Updated data from these trials are pending and extent of survival outcomes is undetermined. The aim of this study was to assess the efficacy of ICIs in advanced CSCC, comprising locally advanced (LA), locoregionally advanced (LR...

Real-life isoniazid and rifampicin plasma concentrations in children: a tool for therap...
https://doi.org/10.1186/s12879-021-06764-7 10.4103/ijmr.IJMR_1961_16 10.1128/AAC.00693-15 10.1093/jac/dkv148 10.1080/17425255.2018.1416093 10.1111/apm.12590 10.1517/17425255.2016.1162785 10.1128/AAC.00756-15 10.1016/j.ijid.2014.12.001 10.1086/598192 10.1136/adc.2004.052175 10.1002/bmc.2920 10.1016/j.jpba.2007.10.025 10.1046/j.1445-5994.2003.00390.x 10.1136/adc.2004.052175 10.1159/000321045 10.1016/S0378-4347(01)00434-0 10.1093/jac/dku210 10.1016/j.ijantimicag.2017.12.004 10.1016/j.ijantimicag.2014.04.019 10.1086/598192 10.1128/AAC.05429-11 10.1371/journal.pone.0102047 10.1371/journal.pmed.1002595 10.1186/s41043-017-0132-y 10.1111/jpc.13458 10.2196/mhealth.8130 10.1186/s13063-019-3483-4 10.2196/mhealth.6837 10.3346/jkms.2020.35.e92 10.1080/02770903.2019.1635153 10.2217/pgs-2018-0166 10.1128/AAC.01833-10 10.1080/17512433.2017.1246179
BMC Infectious Diseases; Tersigni C, Boiardi G et. al.

Oct 23rd, 2021 - Low plasma levels of first-line antitubercular drugs can be counted among the main causes of poor response to antitubercular therapy, and therapeutic drug monitoring has been proposed as a method to promote tailored treatments for both child and adult patients. The main aim of the study was to evaluate serum concentrations of isoniazid (INH) and rifampicin (RIF) and to investigate reasons for s...

The recruitment mechanisms and potential therapeutic targets of podocytes from parietal...
https://doi.org/10.1186/s12967-021-03101-z 10.12688/f1000research.7255.1 10.1007/s00424-017-2016-9 10.1007/s00424-017-2025-8 10.1159/000481634 10.1016/j.semnephrol.2012.06.007 10.1681/asn.2006010089 10.1159/000313943 10.1681/asn.2008070709 10.1155/2015/318935 10.1152/ajprenal.00438.2014 10.1152/ajprenal.00497.2015 10.1681/asn.2006030275 10.1152/ajprenal.00428.2009 10.1152/ajprenal.00516.2011 10.1152/ajprenal.00020.2013 10.1159/000342808 10.1681/asn.2009010122 10.1681/asn.2009020132 10.1681/asn.2010090970 10.1016/j.ajpath.2014.08.007 10.1097/MNH.0b013e32835fefd4 10.1038/ki.2015.152 10.4132/jptm.2016.09.21 10.1152/ajprenal.00266.2019 10.1681/asn.2008070795 10.1681/asn.2013050452 10.18632/aging.101176 10.1681/asn.2014020190 10.1681/asn.2019070696 10.1152/ajprenal.00196.2016 10.1007/s10157-015-1222-z 10.2215/cjn.10571011 10.1681/asn.2012050445 10.1038/ki.2015.273 10.3906/sag-1704-102 10.1016/j.ajpath.2013.04.017 10.1016/j.ajpath.2011.04.003 10.1016/j.ajpath.2011.03.004 10.1038/ki.2013.115 10.18632/aging.103788 10.1152/ajprenal.00144.2015 10.1152/physrev.00005.2017 10.1242/jcs.127308 10.3390/biom9110692 10.1038/ki.2013.48 10.1038/ki.2013.66 10.1007/s00467-007-0504-4 10.1002/dvdy.1164 10.1016/j.semnephrol.2012.06.006 10.1074/jbc.M111.223164 10.1152/ajprenal.00056.2013 10.1093/ajcp/88.3.278 10.1016/j.jpedsurg.2018.09.005 10.1007/978-1-4939-4023-3_2 10.1016/0092-8674(93)90515-r 10.3760/cma.j.issn.0578-1310.2018.10.010 10.1242/dev.153163 10.1016/j.semnephrol.2014.06.008 10.1371/journal.pone.0034907 10.1073/pnas.0901591106 10.1038/nm.3142 10.1016/j.ajpath.2018.07.025 10.1182/blood-2003-07-2459 10.1242/dev.119735 10.1007/s00418-017-1550-z 10.1074/jbc.M109.094334 10.1681/asn.2013101067 10.1016/j.kint.2017.11.014 10.1016/j.kint.2018.08.013 10.1016/j.ajpath.2017.07.004 10.1038/ki.2011.463 10.1002/stem.492 10.1152/ajprenal.00415.2009 10.1016/j.kint.2018.09.011 10.1093/ndt/gfs030 10.1038/nm.2491 10.1038/labinvest.2011.43
Journal of Translational Medicine; Ni L, Yuan C et. al.

Oct 23rd, 2021 - Podocytes are differentiated postmitotic cells which cannot be replaced after podocyte injury. The mechanism of podocyte repopulation after injury has aroused wide concern. Parietal epithelial cells (PECs) are heterogeneous and only a specific subpopulation of PECs has the capacity to replace podocytes. Major progress has been achieved in recent years regarding the role and function of a subset...

Impact of systemic lupus erythematosus on the 5-year survival of critically ill septic ...
https://doi.org/10.1186/s13075-021-02649-x 10.7326/M17-0102 10.1136/annrheumdis-2018-214802 10.1002/art.41577 10.1093/rheumatology/keaa188 10.1016/j.berh.2019.01.013 10.1177/0961203319877947 10.1016/j.chest.2020.03.050 10.1177/1073274820920733 10.1007/s00134-019-05718-7 10.1001/jama.2016.2691 10.1164/rccm.201510-2023OC 10.1111/imr.12499 10.1007/s00134-020-06294-x 10.1001/jama.2016.0287 10.1097/00003246-200107000-00002 10.1177/1759720X20929208 10.1016/j.healthpol.2011.08.007 10.1186/1751-0473-3-17 10.1093/rheumatology/kez103 10.1177/0961203314548884 10.1001/jama.2014.2637 10.1093/rheumatology/ken196 10.1371/journal.pone.0093846 10.1016/j.jmii.2019.10.008 10.1126/science.abd4585 10.1126/science.abd4570 10.1007/s00134-020-05941-7 10.3389/fimmu.2017.00493 10.1517/14728222.2014.863876 10.1038/nature13489 10.1371/journal.pone.0189453 10.1164/rccm.201706-1248LE 10.1016/j.jinf.2019.04.005 10.1136/ard.57.10.582 10.1186/s12879-020-4826-1 10.1056/NEJMoa1415236 10.1186/s13054-016-1497-9 10.1007/s00134-020-06151-x
Arthritis Research & Therapy; Chen HH, Chen HM et. al.

Oct 23rd, 2021 - Infectious disease is an increasing threat to patients with systemic lupus erythematosus (SLE); however, the long-term outcome in critically ill septic patients with SLE remains unclear, and we aimed to address the impact of SLE on 5-year survival in critically ill septic patients. We used the 2003-2017 nationwide data with 825,556 patients with sepsis in Taiwan. We identified lupus cases with ...

Computational determination of toxicity risks associated with a selection of approved d...
https://doi.org/10.1186/s40360-021-00519-5 10.1038/s41586-020-2951-z 10.1016/j.ijantimicag.2020.105924 10.1016/S2213-2600(20)30216-2 10.1177/1740774517727742 10.1039/C5MB00306G 10.1016/j.curtheres.2017.01.007 10.1371/journal.pone.0245962 10.1016/j.molmed.2016.09.006 10.1038/s41586-020-2577-1 10.1038/s41586-020-2286-9 10.1038/nrd1032 10.1016/S1093-3263(01)00123-1 10.1021/ci0203702 10.1371/journal.pone.0204532 10.1186/1758-2946-6-34 10.1038/srep46277 10.1002/ps.4935 10.1021/jm0205651 10.1038/nature04710 10.1021/ci300112j 10.1145/2939672.2939785 10.1016/j.comtox.2017.05.001 10.1007/BF00173538 10.1007/s002280050448 10.1038/newbio231232a0 10.1111/head.12769 10.1016/S0006-2952(98)00336-0 10.1042/CS20201511 10.1038/s41581-020-0279-4 10.1016/j.jemermed.2020.04.004 10.1016/j.urology.2020.04.057 10.1128/AAC.01411-05 10.1016/j.ccr.2011.10.015 10.1093/emboj/20.24.6969 10.1093/emboj/cdg315 10.1021/ml1001954 10.1016/0006-8993(82)90664-3 10.1016/j.cell.2020.02.052 10.1016/S0140-6736(20)30937-5 10.1038/nature02145 10.1161/01.HYP.0000146120.29648.36 10.1038/nm1267 10.1016/j.jaci.2020.05.008 10.1146/annurev.med.47.1.315 10.1111/j.1365-3083.2008.02029.x 10.3389/fchem.2020.00726 10.1002/wcms.1240
BMC Pharmacology & Toxicology; Aminpour M, Delgado WEM et. al.

Oct 23rd, 2021 - The emergence and rapid spread of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) in thelate 2019 has caused a devastating global pandemic of the severe pneumonia-like disease coronavirus disease 2019 (COVID-19). Although vaccines have been and are being developed, they are not accessible to everyone and not everyone can receive these vaccines. Also, it typically takes more than 10...

New Onset Severe Anemia and Fulminant Idiopathic Intracranial Hypertension.
https://doi.org/10.1017/cjn.2021.203
The Canadian Journal of Neurological Sciences. Le Journal... Waisberg E, Yu CW et. al.

Oct 23rd, 2021 - New Onset Severe Anemia and Fulminant Idiopathic Intracranial Hypertension.|2021|Waisberg E,Yu CW,Sverdlichenko I,Micieli JA,|

Reducing worry and rumination in young adults via a mobile phone app: study protocol of...
https://doi.org/10.1186/s12888-021-03536-0 10.1016/S0140-6736(11)60871-4 10.1001/archpsyc.62.6.593 10.1016/S0140-6736(14)61400-8 10.1016/j.jadohealth.2016.08.002 10.1007/s10964-014-0165-0 10.1017/S0033291715001725 10.1186/s12888-020-02857-w 10.1177/0963721413495872 10.1016/j.cbpra.2015.04.004 10.1001/jamapsychiatry.2017.0262 10.2196/mental.4984 10.2196/jmir.2791 10.1002/da.22654 10.1007/s11920-018-0910-2 10.1177/1754073915575406 10.1177/1754073915575404 10.1080/02699930902928969 10.1177/1754073915580601 10.1007/s10919-017-0269-9 10.1080/17439760.2015.1058968 10.1016/j.paid.2006.09.003 10.1146/annurev-clinpsy-032814-112739 10.1111/j.1758-0854.2011.01062.x 10.1521/ijct.2008.1.3.192 10.5127/jep.038813 10.1111/j.1745-6924.2008.00088.x 10.1016/j.brat.2020.103573 10.1037/0033-2909.134.2.163 10.1037/0021-843X.106.2.221 10.1023/A:1023914416469 10.1037/0022-3514.61.1.115 10.1023/A:1019873015594 10.1007/s10608-008-9191-0 10.1037/0021-843X.111.2.350 10.1037/1528-3542.1.1.25 10.1080/15374410802359627 10.1111/jcap.12102 10.1016/j.beth.2011.11.002 10.1016/j.paid.2015.06.034 10.1037/0022-3514.69.1.176 10.1016/j.beth.2006.03.003 10.1192/bjp.bp.110.090282 10.1017/S0033291711002480 10.1017/S0033291718003835 10.1016/j.brat.2016.12.015 10.2196/11349 10.1111/cpsp.12144 10.1016/j.brat.2016.09.011 10.7326/0003-4819-152-11-201006010-00232 10.1186/s13063-018-2735-z 10.2196/jmir.1923 10.1037/0022-3514.67.1.92 10.1016/0005-7967(90)90135-6 10.1046/j.1525-1497.2001.016009606.x 10.1136/jech.2011.143586.86 10.1186/1477-7525-5-63 10.1001/archinte.166.10.1092 10.1007/s10802-018-0401-2 10.1097/01.MLR.0000062554.74615.4C 10.1177/1740774512450098 10.1177/2167702615583840
BMC Psychiatry; Edge D, Newbold A et. al.

Oct 23rd, 2021 - Promoting well-being and preventing poor mental health in young people is a major global priority. Building emotional competence skills via a mobile app may be an effective, scalable and acceptable way to do this. A particular risk factor for anxiety and depression is elevated worry and rumination (repetitive negative thinking, RNT). An app designed to reduce RNT may prevent future incidence of...

Preemptive analgesic effectiveness of single dose intravenous ibuprofen in infants unde...
https://doi.org/10.1186/s12887-021-02907-6 10.1016/j.clp.2015.02.005 10.1016/B978-0-323-06612-9.00025-0 10.1111/j.0001-5172.2004.00407.x 10.1111/j.1365-2044.1995.tb04509.x 10.1597/1545-1569_2002_039_0145_aofpao_2.0.co_2 10.1213/00000539-199377020-00026 10.1016/j.joms.2018.09.010 10.1111/pan.12302 10.1097/00000539-200104000-00020 10.1111/pan.12393 10.1016/j.phrs.2011.08.010 10.1111/pan.12381 10.1016/0952-8180(94)00001-k 10.1542/peds.2007-0064 10.1046/j.1460-9592.2000.00530.x 10.1597/14-080 10.1111/j.1460-9592.2006.02018.x 10.1111/j.1460-9592.2010.03347.x 10.1093/bja/74.5.506 10.1111/j.1460-9592.2010.03262.x 10.1097/SCS.0000000000006633 10.1097/EJA.0000000000000900 10.1097/PEC.0000000000001505
BMC Pediatrics; Peng ZZ, Wang YT et. al.

Oct 23rd, 2021 - Correction surgery for cleft palate is recommended between 9 and 18 months of age. Patients suffer from acute pain after palatoplasty. Clinicians are hesitant to use opioids for analgesia concerning the potential high risk of respiratory adverse events. Intravenous ibuprofen perhaps be a suitable adjuvant to pain relief. We try to assess whether preoperative administration of intravenous ibupro...

Acceptability and feasibility of the school-engaged social and behavior change communic...
https://doi.org/10.1186/s12889-021-11995-z 10.1186/s12936-015-1047-y 10.1186/1475-2875-9-98 10.1186/1748-5908-5-67 10.1177/1098214012452715 10.1186/1748-5908-2-40 10.1007/s10488-010-0319-7 10.1186/s13012-017-0635-3 10.1007/s11121-015-0606-3 10.1186/s12889-021-11216-7 10.1371/journal.pone.0235189 10.1186/1478-4491-11-39 10.1111/napa.12064 10.1186/1748-5908-5-99 10.1002/jcop.20143 10.1093/heapro/dav059 10.1016/S0749-3797(98)00043-9 10.31899/rh4.1033 10.1007/s10464-008-9165-0 10.1093/heapro/dau016 10.1186/s13012-019-0941-z 10.2105/AJPH.2008.155234 10.1080/03637759209376276 10.1111/j.1460-2466.2001.tb02900.x 10.1177/001440291207800402 10.1007/s11121-008-0100-2 10.1186/s40814-019-0542-2 10.3200/PSFL.48.3.36-43 10.1016/j.jsp.2013.03.001 10.1080/02796015.2008.12087866
BMC Public Health; Abamecha F, Midaksa G et. al.

Oct 23rd, 2021 - Evidence on process outcomes such as acceptability, and feasibility of behavior change communication interventions are important in program evaluation to understand how, and why such a program works. However; documented evidence on the issue is not available as far as the social and behavior change communication (SBCC) on malaria is concerned. Enrolling the frontline providers this study measur...

Comparison of thyroid function in different emotional states of drug-naïve patients wit...
https://doi.org/10.1186/s12902-021-00869-5 10.1038/nrdp.2018.8 10.1001/archgenpsychiatry.2011.12 10.1053/comp.2001.23143 10.1080/03007995.2019.1636017 10.1111/j.1399-5618.2008.00581.x 10.1016/j.jad.2017.09.011 10.1111/j.1399-5618.2007.00327.x 10.1111/acps.12003 10.1038/mp.2010.101 10.3390/medicina55080403 10.1016/S0140-6736(11)61516-X 10.1097/WNF.0b013e31823429a7 10.4061/2011/306367 10.1097/01.jcp.0000169037.17884.79 10.1055/s-2000-7973 10.1016/j.psyneuen.2003.08.004 10.1176/appi.ajp.159.1.116 10.2147/NDT.S196661 10.1016/j.genhosppsych.2004.10.002 10.1097/YCO.0b013e3283387b50 10.5152/npa.2017.12457 10.1007/BF03346311 10.1017/S1121189X00004322 10.1016/j.jpsychires.2018.09.014 10.1016/0165-1781(94)90047-7 10.1016/S0893-133X(97)00181-4 10.1001/archpsyc.1982.04290030045008 10.1001/archpsyc.1990.01810170027005 10.1016/S0193-953X(05)70285-9 10.1016/S0006-3223(98)80003-6
BMC Endocrine Disorders; Zhao S, Zhang X et. al.

Oct 23rd, 2021 - Previous studies have shown that bipolar disorder is closely related to thyroid dysfunction. Psychiatric drugs have a large or small effect on thyroid function, and thyroid hormone levels can also affect the effect of drug treatment. Therefore, the purpose of this study is assessment the thyroid function of drug-naive bipolar disorder across different mood states, with the expectation of provid...

Nosocomial cluster of carbapenemase-producing Enterobacter cloacae in an intensive care...
https://doi.org/10.1186/s13756-021-01022-6 10.1016/S0140-6736(20)30154-9 10.1016/S1473-3099(18)30605-4 10.1186/s13756-020-0703-3 10.1128/AAC.50.4.1282-1286.2006 10.1093/jac/dkaa345 10.1371/journal.pone.0135044 10.1016/j.meegid.2017.07.019 10.1093/jac/dky257 10.1128/CMR.00115-18 10.1093/jacamr/dlab032 10.1186/s13756-020-00820-8
Antimicrobial Resistance and Infection Control; Miltgen G, Garrigos T et. al.

Oct 23rd, 2021 - Concomitant prevention of SARS-CoV-2 and extensively drug-resistant bacteria transmission is a difficult challenge in intensive care units dedicated to COVID-19 patients. We report a nosocomial cluster of four patients carrying NDM-1 plasmid-encoded carbapenemase-producing Enterobacter cloacae. Two main factors may have contributed to cross-transmission: misuse of gloves and absence of change o...

Pilot Testing of Simulation in the Evaluation of a Novel, Rapidly Deployable Electronic...
https://doi.org/10.1017/dmp.2021.302
Disaster Medicine and Public Health Preparedness; Applebury DE, Robinson EJ et. al.

Oct 23rd, 2021 - The SARS-CoV-2 pandemic has highlighted the need for rapid creation and management of ICU field hospitals with effective remote monitoring which is dependent on the rapid deployment and integration of an Electronic Health Record (EHR). We describe the use of simulation to evaluate a rapidly scalable hub-and-spoke model for EHR deployment and monitoring using asynchronous training. We adapted ex...

Association of Genetic Variants With Outcomes in Patients With Nonischemic Dilated Card...
https://doi.org/10.1016/j.jacc.2021.08.039
Journal of the American College of Cardiology; Escobar-Lopez L, Ochoa JP et. al.

Oct 23rd, 2021 - The clinical relevance of genetic variants in nonischemic dilated cardiomyopathy (DCM) is unsettled. The study sought to assess the prognostic impact of disease-causing genetic variants in DCM. Baseline and longitudinal clinical data from 1,005 genotyped DCM probands were retrospectively collected at 20 centers. A total of 372 (37%) patients had pathogenic or likely pathogenic variants (genotyp...

Menopause in women with schizophrenia, schizoaffective disorder and bipolar disorder.
https://doi.org/10.1016/j.maturitas.2021.07.003
Maturitas Szeliga A, Stefanowski B et. al.

Oct 23rd, 2021 - The transition to menopause, usually occurring between the ages of 40 and 55, is a time when women are particularly vulnerable. When preexisting mental illness is present, symptoms are often amplified during this period. Moreover, women with mental illnesses experience menopausal symptoms similarly to healthy women. In this narrative review we summarize the current data regarding menopause in w...

The Evolving Science of Dilated Cardiomyopathy.
https://doi.org/10.1016/j.jacc.2021.08.038
Journal of the American College of Cardiology; Hershberger RE

Oct 23rd, 2021 - The Evolving Science of Dilated Cardiomyopathy.|2021|Hershberger RE,|

miR-149-3p suppressed epithelial-mesenchymal transition and tumor development in acute ...
https://doi.org/10.1080/16078454.2021.1990502
Hematology (Amsterdam, Netherlands); Tian Y, Jiang Y et. al.

Oct 23rd, 2021 - Acute myeloid leukemia (AML) is a form of primary acute leukemia with high mortality. Our previous study demonstrated that miR-149-3p was down-regulated in chemoresistant acute leukemia cells. However, the biological function of miR-149-3p in AML needs to be further explored. Herein, the expression of miR-149-3p was overexpressed/silenced in U-937 human AML cells via transfection with miR-149-3...

Clinical values of gene alterations as marker of minimal residual disease in non-M3 acu...
https://doi.org/10.1080/16078454.2021.1990503
Hematology (Amsterdam, Netherlands); Yu T, Chi J et. al.

Oct 23rd, 2021 - Acute myeloid leukemia (AML) is a malignant disease of the hematopoietic system. Residual leukemic cells after treatment are associated with relapse. Thus, detecting minimal residual disease (MRD) is significant. Major techniques for MRD assessment include multiparameter flow cytometry (MFC), polymerase chain reaction (PCR), and next-generation sequencing (NGS). At a molecular level, AML is the...

Assessment and Management of Loose Bodies in the Knee Joint and Related Disease: A Narr...
https://doi.org/10.2174/1573397117666211021165807
Current Rheumatology Reviews; Zmerly H, Moscato M et. al.

Oct 23rd, 2021 - Loose bodies are frequently encountered during clinical activity and a common finding during knee arthroscopy. Usually, treatment consists of the removal of the loose bodies, which can be challenging even for experienced surgeons. The excision alone is not always the complete treatment, because loose bodies are generally secondary to other diseases that can cause persistent symptoms with the ri...

Word Fluency Test Performance in Primary Progressive Aphasia and Primary Progressive Ap...
https://doi.org/10.1044/2021_AJSLP-21-00058
American Journal of Speech-language Pathology; Scheffel L, Duffy JR et. al.

Oct 23rd, 2021 - Purpose This study compared performance on three-word fluency measures among individuals with primary progressive aphasia (PPA) and primary progressive apraxia of speech (PPAOS), and examined the relationship between word fluency and other measures of language and speech. Method This study included 106 adults with PPA and 30 adults with PPAOS. PPA participants were divided into three clinical s...

Multiple Immunofluorescence Imaging Analysis Reveals Differential Expression of Disialo...
https://doi.org/10.1177/10935266211048733
Pediatric and Developmental Pathology : the Official Jour... Nishimaki H, Nakanishi Y et. al.

Oct 23rd, 2021 - Peripheral neuroblastic tumors (pNTs) are the most common childhood extracranial solid tumors. There are several therapeutic strategies targeting disialoganglioside GD2. Disialoganglioside GD3 has become a potential target. However, the mechanism by which pNTs express GD3 and GD2 remains unclear. We investigated the combined expression status of GD3 and GD2 in pNTs and delineated their clinicop...

Effects of Tham Nasal Alkalinization on Airway Microbial Communities: A Pilot Study in ...
https://doi.org/10.1177/00034894211051814
The Annals of Otology, Rhinology, and Laryngology; Holliday ZM, Launspach JL et. al.

Oct 23rd, 2021 - In cystic fibrosis (CF), loss of CFTR-mediated bicarbonate secretion reduces the airway surface liquid (ASL) pH causing airway host defense defects. Aerosolized sodium bicarbonate can reverse these defects, but its effects are short-lived. Aerosolized tromethamine (THAM) also raises the ASL pH but its effects are much longer lasting. In this pilot study, we tested the hypothesis that nasally ad...

The T-type Calcium Channel Cav3.1 in Y79 Retinoblastoma Cells is Regulated by the Epide...
https://doi.org/10.1080/02713683.2021.1988982
Current Eye Research; Banderali U, Jain M et. al.

Oct 23rd, 2021 - Retinoblastoma is the most frequent intraocular cancer in children. It is also one of the most common causes for enucleation and carries a significant morbidity rate in affected individuals. Hence, studies on its pathophysiological and growth regulatory mechanisms are urgently needed to identify more effective novel therapeutics. Using the Y79 retinoblastoma cell line, we investigated the elect...

Monitoring basal autophagy in the retina utilizing CAG-mRFP-EGFP-MAP1LC3B reporter mous...
https://doi.org/10.1080/15548627.2021.1969634
Autophagy Ramachandra Rao S, Fliesler SJ

Oct 23rd, 2021 - We describe the utility of a tandem-tagged autophagy reporter mouse model (CAG-RFP-EGFP-MAP1LC3B) in investigating basal macroautophagic/autophagic flux in the neural retina. Western blot, in situ hybridization, immunohistochemistry, and confocal microscopy showed that CAG promoter-driven expression of RFP-EGFP-MAP1LC3B increased "cytosolic" RFP-EGFP-LC3B-I levels, whereas RFP-EGFP-LC3B-II deco...

Hepatocellular carcinoma in nonalcoholic fatty liver disease with or without cirrhosis:...
https://doi.org/10.1186/s12876-021-01978-0 10.1002/hep.29546 10.1016/j.cgh.2018.05.057 10.1038/s41575-019-0145-7 10.1111/apt.14937 10.1002/hep.28368 10.1002/ijc.25797 10.1016/j.cgh.2011.01.023 10.1007/s12072-015-9679-0 10.1016/j.cgh.2015.07.019 10.1053/j.gastro.2018.08.024 10.1111/liv.14087 10.1111/apt.14261 10.1038/ajg.2011.327 10.1002/hep.29367 10.1111/jgh.14608 10.1136/amiajnl-2011-000782 10.1002/cam4.1998 10.1002/ijc.30784 10.18632/oncotarget.20127 10.1074/jbc.M112.348763 10.3389/fgene.2016.00168 10.1186/s12916-019-1321-x 10.1002/ijc.26165 10.1038/s41416-018-0007-z 10.1111/jebm.12270 10.1111/liv.12226 10.1111/hepr.12656 10.1016/j.cgh.2017.09.041 10.1002/hep.24397 10.1016/j.cgh.2008.02.012 10.1053/j.gastro.2008.03.073
BMC Gastroenterology; Pinyopornpanish K, Khoudari G et. al.

Oct 23rd, 2021 - There are limited data regarding the factors associated with hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) patients without cirrhosis. We sought to determine the prevalence and factors associated with HCC in NAFLD patients with or without cirrhosis. Adults with NAFLD (June 2015 to May 2020) were identified using the electronic health record database (Explorys Inc, ...

Prognostic indicators and outcomes following surgical management of metastatic cutaneou...
https://doi.org/10.1016/j.bjoms.2021.01.003
The British Journal of Oral & Maxillofacial Surgery; O'Connell JE, Saeed A et. al.

Oct 23rd, 2021 - Metastatic cutaneous SCC carries a poor prognosis with five-year survival of 25%-57%. The aim of this study is to examine the outcomes following surgery with adjuvant therapy for management of metastatic cSCC in a UK-based population. This is a retrospective review of patients with metastatic cSCC of the head and neck who underwent primary surgery at a regional center during a six-year period. ...

Is treating severe He FH so easy? A combined treatment between lipoprotein apheresis an...
https://doi.org/10.1016/j.transci.2021.103258
Transfusion and Apheresis Science : Official Journal of T... Dal Pino B, Sbrana F et. al.

Oct 23rd, 2021 - Despite advance in pharmacotherapy of lipid disorders, many heterozygous Familial Hypercholesterolemia patients do not achieve a desirable lipid target to significantly reduce the risk of atherosclerotic cardiovascular disease. The aim of the present work is to evaluate the interaction between Lipoprotein apheresis (LA) and PCSK9i in a small FH cohort in which the guidelines therapeutic target ...

Improvements in Health-related Quality of Life and Symptoms in Patients With Previously...
https://doi.org/10.1016/j.clml.2021.09.008
Clinical Lymphoma, Myeloma & Leukemia; Danilov AV, Yimer HA et. al.

Oct 23rd, 2021 - We evaluated health-related quality of life (HRQoL) in patients with chronic lymphocytic leukemia (CLL) receiving first-line chemoimmunotherapy in the GIBB single-arm, Phase II study of obinutuzumab plus bendamustine (BG). Patients received six 28-day cycles of BG and were followed for up to 27 months. HRQoL was assessed using the European Organization for Research and Treatment of Cancer Quali...

Prognostic of Core Binding Factor (CBF) Acute Myeloid Leukemia With Complex Karyotype.
https://doi.org/10.1016/j.clml.2021.09.007
Clinical Lymphoma, Myeloma & Leukemia; Marcault C, Boissel N et. al.

Oct 23rd, 2021 - Core-binding factor acute myeloid leukemia (CBF AML) with recurrent genetic abnormalities inv(16)(p13.1q22) or t(16;16)(p13.1;q22)/ CBFB-MYH11 are usually prognostically favorable but heterogeneous group and additional abnormalities change their prognosis. To evaluate the impact of a complex karyotype on CBF AML prognosis, we included 24 patients with a median age of 56.4 years (23.2-83.3) and ...

Injectable Hypomethylating Agents for Management of Myelodysplastic Syndromes: Patients...
https://doi.org/10.1016/j.clml.2021.09.009
Clinical Lymphoma, Myeloma & Leukemia; Zeidan AM, Jayade S et. al.

Oct 23rd, 2021 - Until recently, patients with MDSs could receive HMAs via intravenous (IV) or subcutaneous (SC) administration. An oral HMA was recently approved as an alternative to IV/SC administration. This study assessed the impact of IV/SC HMA on MDS patients, and their experience of, challenges with, and views about oral MDS treatment. We conducted an online cross-sectional survey among adult MDS patient...

Bing-Neel Syndrome: Update on the Diagnosis and Treatment.
https://doi.org/10.1016/j.clml.2021.09.014
Clinical Lymphoma, Myeloma & Leukemia; Nanah A, Al Hadidi S

Oct 23rd, 2021 - Bing-Neel syndrome (BNS) is a rare syndrome that occurs in patients with Waldenstrom macroglobulinemia and is characterized by lymphoplasmacytic infiltration into the leptomeningeal tissue and/or the central nervous system. It represents an extramedullary manifestation which may translate into various neurological symptoms. Accurate diagnosis of BNS can be established via histologic sampling an...

Changes in Ventricular and Cortical Volumes following Shunt Placement in Patients with ...
https://doi.org/10.3174/ajnr.A7323
AJNR. American Journal of Neuroradiology; Cogswell PM, Murphy MC et. al.

Oct 23rd, 2021 - While changes in ventricular and extraventricular CSF spaces have been studied following shunt placement in patients with idiopathic normal pressure hydrocephalus, regional changes in cortical volumes have not. These changes are important to better inform disease pathophysiology and evaluation for copathology. The purpose of this work is to investigate changes in ventricular and cortical volume...

Anatomic Neuroimaging Characteristics of Posterior Fossa Type A Ependymoma Subgroups.
https://doi.org/10.3174/ajnr.A7322
AJNR. American Journal of Neuroradiology; Sabin ND, Hwang SN et. al.

Oct 23rd, 2021 - Posterior fossa type A (PFA) ependymomas have 2 molecular subgroups (PFA-1 and PFA-2) and 9 subtypes. Gene expression profiling suggests that PFA-1 and PFA-2 tumors have distinct developmental origins at different rostrocaudal levels of the brainstem. We, therefore, tested the hypothesis that PFA-1 and PFA-2 ependymomas have different anatomic MR imaging characteristics at presentation. Two neu...

European Glaucoma Society Terminology and Guidelines for Glaucoma, 5th Edition.
https://doi.org/10.1136/bjophthalmol-2021-egsguidelines
The British Journal of Ophthalmology;

Oct 23rd, 2021 - The only time is now. Every "now" is unique. Responsible persons ask themselves, "How can I act well now?" The answers will differ for every person, because just as every situation is unique, so is every person different from every other person. But surely there must be some algorithm that will assist us in coming to the right answer. Unfortunately, no, for there is no right answer. There is on...

Video game therapy on mobility and dual tasking in multiple sclerosis: study protocol f...
https://doi.org/10.1136/bmjopen-2021-052005
BMJ Open; Baroni A, Fregna G et. al.

Oct 23rd, 2021 - Multiple sclerosis (MS) is one of the major causes of disability in young adults and affects mobility, compromising daily living activities and participation in social life. Cognitive domain is also frequently impaired in people with MS (PwMS), particularly the capacity to perform dual-task activities. Impaired cognitive processing abilities need to be treated, and motor and cognitive aspects n...