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About 1,800,148 results

VIDEO: Innovative technology reframes ‘controlled’ glaucoma
https://www.healio.com/news/ophthalmology/20210514/video-innovative-technology-reframes-controlled-glaucoma

May 14th, 2021 - WAILEA, Hawaii — In this video from Hawaiian Eye, I. Paul Singh, MD, discusses how innovative technology has changed his definition of controlled glaucoma.

Weigh pros, cons of at-home IOP measurements
https://www.healio.com/news/ophthalmology/20210513/weigh-pros-cons-of-athome-iop-measurements

May 13th, 2021 - WAILEA, Hawaii — Glaucoma patients may ask for ways to monitor IOP between visits, but ophthalmologists should weigh benefits and drawbacks of at-home monitoring options, according to speakers at Hawaiian Eye 2021. “I have that question all the time, actually,” Sahar Bedrood, MD, PhD, said. “Some of my patients are significantly worried, so they come in.” Options for at-home eye care include re...

VIDEO: Bedrood discusses experience with iStent inject
https://www.healio.com/news/ophthalmology/20210512/video-bedrood-discusses-experience-with-istent-inject

May 12th, 2021 - WAILEA, Hawaii — In this video from Hawaiian Eye 2021, Sahar Bedrood, MD, PhD, discusses how she has incorporated the iStent inject (Glaukos) into her practice, patient selection and the benefits of using the device in those with glaucoma.

Fluconazole - fluconazole tablet-REMEDYREPACK INC.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d11e0926-cd15-49ba-b0ee-2b6d4e009dd8

Dec 30th, 2022 - Fluconazole tablets are indicated for the treatment of: Vaginal candidiasis (vaginal yeast infections due to Candida). Oropharyngeal and esophageal candidiasis. In open noncomparative studies of relatively small numbers of patients, fluconazole tablets were also effective for the treatment of Candida urinary tract infections, peritonitis, and systemic Candida infections including candidemia, di...

Evolving Patterns of Metastasis in Renal Cell Carcinoma: Do We Need to Perform Routine Bone Imaging?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523177/
Journal of Kidney Cancer and VHL; Lin J

Oct 13th, 2021 - Advance diagnostic and treatment modalities have improved outcomes for renal cell carcinoma (RCC) patients, but the prognosis for those with metastatic disease (mRCC) remains poor. As given metastatic distribution is critical in guiding treatment decisions for mRCC patients, we evaluated evolving metastatic patterns to assess if our current practice standards effectively address patient needs.

Germline Variants Identified in Patients with Early-onset Renal Cell Carcinoma Referred for Germline Genetic Testing
https://pubmed.ncbi.nlm.nih.gov/34654685/
European Urology Oncology; Truong H

Oct 12th, 2021 - Despite guidelines recommending genetic counseling for patients with early-onset renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations and clinical associations in patients with early-onset RCC are lacking.

Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain
https://www.biorxiv.org/content/10.1101/2022.01.07.475453v1
BioRxiv Fernandez-Castaneda A, .

Jan 10th, 2022 - Survivors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection frequently experience lingering neurological symptoms, including impairment in attention, concentration, speed of information processing and memory. This long-COVID cognitive syndrome shares many features with the syndrome of cancer therapy-related cognitive impairment (CRCI).

Biomarkers of Post-COVID Depression
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8470902/
Journal of Clinical Medicine; Lorkiewicz P

Sep 14th, 2021 - The COVID-19 pandemic is spreading around the world and 187 million people have already been affected. One of its after-effects is post-COVID depression, which, according to the latest data, affects up to 40% of people who have had SARS-CoV-2 infection. A very important issue for the mental health of the general population is to look for the causes of this complication and its biomarkers.

Intranasal inhibitor blocks omicron and other variants of SARS-CoV-2
https://www.researchsquare.com/article/rs-1196079/v1
Research Square; Mäkelä AR, .

Dec 28th, 2021 - The emergence of the SARS-CoV-2 Omicron variant capable of escaping neutralizing antibodies emphasizes the need for prophylactic strategies to complement vaccination in fighting the COVID-19 pandemic. Nasal epithelium is rich in the ACE2 receptor and important for SARS-CoV-2 transmission by supporting early viral replication before seeding to the lung1. Intranasal administration of SARS-CoV-2 n...

CDC Updates and Shortens Recommended Isolation and Quarantine Period for General Population
https://www.cdc.gov/media/releases/2021/s1227-isolation-quarantine-guidance.html
Centers for Disease Control and Prevention (CDC)

Dec 27th, 2021 - Given what we currently know about COVID-19 and the Omicron variant, CDC is shortening the recommended time for isolation from 10 days for people with COVID-19 to 5 days, if asymptomatic, followed by 5 days of wearing a mask when around others. The change is motivated by science demonstrating that the majority of SARS-CoV-2 transmission occurs early in the course of illness, generally in the 1-...

The Omicron variant is highly resistant against antibody-mediated neutralization – implications for control of the COVID-19 pandemic
https://www.cell.com/cell/fulltext/S0092-8674(21)01495-1
Cell Hoffmann M, .

Dec 23rd, 2021 - The rapid spread of the SARS-CoV-2 Omicron variant suggests that the virus might become globally dominant. Further, the high number of mutations in the viral spike-protein raised concerns that the virus might evade antibodies induced by infection or vaccination. Here, we report that the Omicron spike was resistant against most therapeutic antibodies but remained susceptible to inhibition by Sot...

Outbreak caused by the SARS-CoV-2 Omicron variant in Norway, November to December 2021
https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2021.26.50.2101147
Eurosurveillance Brandal LT, .

Dec 15th, 2021 - On 30 November 2021 the Norwegian Institute of Public Health (NIPH) was notified by a local laboratory in Oslo of a coronavirus disease (COVID-19) case with suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (VOC) (Phylogenetic Assignment of Named Global Outbreak Lineages (Pangolin) designation B.1.1.529 BA.1) infection [1]. The laboratory provided...

Latest on Omicron Variant and COVID-19 Vaccine Protection
https://directorsblog.nih.gov/2021/12/14/the-latest-on-the-omicron-variant-and-vaccine-protection/
NIH Director's Blog; Collins FS.

Dec 14th, 2021 - There’s been great concern about the new Omicron variant of SARS-CoV-2, the coronavirus that causes COVID-19. A major reason is Omicron has accumulated over 50 mutations, including about 30 in the spike protein, the part of the coronavirus that mRNA vaccines teach our immune systems to attack. All of these genetic changes raise the possibility that Omicron could cause breakthrough infections in...

The epidemiological relevance of the COVID-19-vaccinated population is increasing
https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(21)00258-1/fulltext
The Lancet; Kampf G.

Dec 1st, 2021 - High COVID-19 vaccination rates were expected to reduce transmission of SARS-CoV-2 in populations by reducing the number of possible sources for transmission and thereby to reduce the burden of COVID-19 disease. Recent data, however, indicate that the epidemiological relevance of COVID-19 vaccinated individuals is increasing. In the UK it was described that secondary attack rates among househol...

Call to apply a consistent scale in public COVID-19 reporting
https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(21)00250-7/fulltext
The Lancet; Kampf G.

Dec 1st, 2021 - The Robert Koch-Institute in Germany regularly reports about the national COVID-19 situation and population-based vaccination level. But a consistent scale is not used. A person is classified as “COVID-19 case” whenever tested positive for SARS-CoV-2 irrespective of any symptoms. But symptomatic fully vaccinated COVID-19 patients are described as “probable breakthrough infection”

Where did ‘weird’ Omicron come from?
https://www.science.org/content/article/where-did-weird-omicron-come
Science Kupferschmidt K.

Dec 1st, 2021 - Since South African scientists announced last week they had identified an unsettling new variant of SARS-CoV-2, the world has anxiously awaited clues about how it might change the trajectory of the pandemic. But as big a mystery—if less urgent—is where and how Omicron evolved, and what lessons its emergence holds for avoiding future dangerous variants.

Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants
https://www.biorxiv.org/content/10.1101/2021.07.19.452771v1
BioRxiv Tada T, Zhou H et. al.

Jul 19th, 2021 - The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible decreases in vaccine efficacy. Here, neutralizing antibody titers elicited by mRNA-based and an adenoviral vector-based vaccine against variant pseudotyped viruses were compared.

DSHS Statement on Monkeypox Investigation
https://www.dshs.texas.gov/news/releases/2021/20210716.aspx
Texas Health and Human Services

Jul 16th, 2021 - The Texas Department of State Health Services is working with Dallas County Health and Human Services and the CDC to investigate a single case of monkeypox virus infection in a Dallas County resident who recently returned from Nigeria. The patient is isolated in the hospital, and the public health investigation has identified a few people who may have been exposed in Dallas and are monitoring t...

CDC and Texas Confirm Monkeypox In U.S. Traveler
https://www.cdc.gov/media/releases/2021/s0716-confirm-monkeypox.html
Centers for Disease Control and Prevention (CDC)

Jul 16th, 2021 - The Centers for Disease Control and Prevention (CDC) and the Texas Department of State Health Services confirmed on July 15 a case of human monkeypox in a U.S. resident who recently traveled from Nigeria to the United States. The person is currently hospitalized in Dallas. CDC is working with the airline and state and local health officials to contact airline passengers and others who may have ...

First Alternative to Eye Injections for Age-related Macular Degeneration Shown Effective
https://www.aao.org/newsroom/news-releases/detail/first-alternative-to-amd-eye-injections-effective
American Academy of Ophthalmology

Nov 15th, 2021 - NEW ORLEANS, La. – An implant that delivers medication to the back of the eye was found to effectively treat age-related macular degeneration (AMD) for at least six months. This represents a vast improvement over the typical regimen of nearly monthly eye injections. The implant offers more than convenience for patients and physicians, it provides an opportunity for more consistent treatment so ...

EU lists rare spinal condition as side effect of J&J COVID-19 shot
https://www.mdedge.com/neurology/article/248627/covid-19-updates/eu-lists-rare-spinal-condition-side-effect-jj-covid-19
MDedge Reuters Staff

Nov 12th, 2021 - (Reuters) - Europe’s drug regulator has recommended adding a rare type of spinal inflammation called transverse myelitis as a side-effect of Johnson & Johnson’s single-dose COVID-19 vaccine. Reports of this serious neurological illness were also at the heart of trial halts in the early stages of development for both AstraZeneca and J&J’s shots, which are based on similar technology.

Global Progress Against Measles Threatened Amidst COVID-19 Pandemic
https://www.cdc.gov/media/releases/2021/s1110-measles-progress.html
Centers for Disease Control and Prevention (CDC)

Nov 10th, 2021 - The largest increase in unvaccinated children in 20 years and critical gaps in disease surveillance increase risk of measles outbreaks, putting lives at risk: WHO, CDC

SARS-CoV-2 vaccine protection and deaths among US veterans during 2021
https://www.science.org/doi/10.1126/science.abm0620
Science Cohn BA, .

Nov 4th, 2021 - The messenger RNA vaccines BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna) and the viral vector vaccine JNJ-78436735 (Janssen) have effectively prevented clinically significant disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since their rollout in the U.S. in late 2020 (1, 2).

In Covid-19 vaccinated people, those with prior infection likely to have more antibodies
https://www.eurekalert.org/news-releases/933401
EurekAlert!

Nov 1st, 2021 - In what is believed to be one of the largest studies of its kind, Johns Hopkins Medicine researchers have shown that antibody levels against SARS-CoV-2 (the COVID-19 virus) stay more durable — that is, remain higher over an extended period of time — in people who were infected by the virus and then received protection from two doses of messenger RNA (mRNA) vaccine compared with those who only g...

Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study
https://www.sciencedirect.com/science/article/pii/S1473309921006484
The Lancet Infectious Diseases; Singanayagam A, .

Oct 29th, 2021 - The SARS-CoV-2 delta (B.1.617.2) variant is highly transmissible and spreading globally, including in populations with high vaccination rates. We aimed to investigate transmission and viral load kinetics in vaccinated and unvaccinated individuals with mild delta variant infection in the community.

Is It Ethical to Turn Away New Patients Who Refuse COVID-19 Vaccinations?
https://www.medscape.com/viewarticle/960793
Medscape Wilner AN, Pies RW.

Oct 20th, 2021 - The ongoing pandemic has raised complex, often troubling ethical issues for medical professionals. In addition to the enormous emotional and logistical burdens imposed by caring for those with COVID-19, there is now the stress and ambivalence in dealing with patients who have refused vaccination against SARS-CoV-2 infection. In this dialogue, neurologist Dr Andrew N. Wilner and psychiatrist/...

Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report
https://www.medrxiv.org/content/10.1101/2021.10.10.21264827v1.full.pdf
Medrxiv Atmar RL, .

Oct 13th, 2021 - Background: While Coronavirus disease 2019 (Covid-19) vaccines are highly effective, breakthrough infections are occurring. Booster vaccinations have recently received emergency use authorization (EUA) for certain populations but are restricted to homologous mRNA vaccines. We evaluated homologous and heterologous booster vaccination in persons who had received an EUA Covid-19 vaccine regimen.

Novel biomarkers for acute respiratory distress syndrome: genetics, epigenetics and tra...
https://doi.org/10.2217/bmm-2021-0749
Biomarkers in Medicine; Zheng F, Pan Y et. al.

Jan 15th, 2022 - Acute respiratory distress syndrome (ARDS) can be induced by multiple clinical factors, including sepsis, acute pancreatitis, trauma, intestinal ischemia/reperfusion and burns. However, these factors alone may poorly explain the risk and outcomes of ARDS. Emerging evidence suggests that genomic-based or transcriptomic-based biomarkers may hold the promise to establish predictive or prognostic s...

Spatiotemporal variations in exposure: Chagas disease in Colombia as a case study.
https://doi.org/10.1186/s12874-021-01477-6 10.1016/S0140-6736(14)61682-2 10.1016/j.gheart.2015.06.001 10.1136/bmjgh-2017-000345 10.1016/j.socscimed.2017.01.002 10.1016/j.gheart.2015.06.003 10.1126/scitranslmed.aax4144 10.1371/journal.pmed.1001638 10.1371/journal.pntd.0008102 10.1016/j.vaccine.2016.10.059 10.1371/journal.pone.0194931 10.1016/j.pt.2007.08.023 10.1371/journal.pntd.0008033 10.1007/s00265-010-1037-6 10.1080/01621459.1993.10476408 10.4159/harvard.9780674428928 10.4269/ajtmh.15-0197 10.1155/2016/1439090 10.1038/sdata.2018.214 10.1198/jabes.2009.08038 10.1007/s11749-018-0599-x 10.1017/S0950268807009879 10.1016/S1471-4922(02)00013-2 10.1016/bs.apar.2014.12.004 10.2307/1925711 10.1007/s13280-012-0344-8 10.1016/j.actatropica.2009.07.019
BMC Medical Research Methodology; Ledien J, Cucunubá ZM et. al.

Jan 15th, 2022 - Age-stratified serosurvey data are often used to understand spatiotemporal trends in disease incidence and exposure through estimating the Force-of-Infection (FoI). Typically, median or mean FoI estimates are used as the response variable in predictive models, often overlooking the uncertainty in estimated FoI values when fitting models and evaluating their predictive ability. To assess how thi...

Large tumour volume reduction of IDH-mutated anaplastic glioma involving the insular re...
https://doi.org/10.1186/s12883-021-02548-3 10.1056/NEJMoa0808710 10.1200/JCO.2013.49.3726 10.1007/s00401-015-1398-z 10.1007/s00401-010-0777-8 10.1227/NEU.0000000000000779 10.1007/s10143-017-0918-9 10.1007/s00701-012-1541-8 10.1007/s11060-016-2110-4 10.1007/s11060-015-1867-1 10.1093/neuros/nyx265 10.1093/neuonc/noaa225 10.3171/2009.6.JNS0952 10.1186/s13014-017-0782-3 10.1186/s12885-016-2399-6 10.1016/j.radonc.2010.08.001 10.1016/j.jocn.2018.11.005 10.1007/s00401-007-0243-4 10.1007/s00401-016-1545-1 10.3171/2015.4.JNS1521 10.1200/JCO.2012.43.2674 10.1200/JCO.2012.43.2229 10.1200/JCO.2017.72.7511 10.1200/JCO.2016.67.1222 10.1093/neuonc/now121 10.2967/jnumed.111.097352 10.1007/s11940-017-0469-y 10.1227/01.neu.0000318159.21731.cf 10.1093/neuonc/nox176 10.1093/annonc/mdx230 10.1007/s11060-019-03261-5 10.1016/s0140-6736(02)11398-5 10.3171/2012.8.JNS12393 10.1016/j.radonc.2021.04.023 10.1111/1754-9485.12850 10.1093/neuonc/noz124
BMC Neurology; Metz G, Jayamanne D et. al.

Jan 15th, 2022 - The impact of near-total resection of IDH-mutated anaplastic glioma (IDHmutAG) is well-established but there remains uncertainty of benefit in tumours of the insular cortex where the extent of safe resection may be limited. This study aimed to assess tumour volume reduction in patients following IMRT and impact of residual post-surgical volume. Patients with IDHmutAG involving insular cortex ma...

A randomized crossover study of functional electrical stimulation during walking in spa...
https://doi.org/10.1186/s12887-021-03037-9
BMC Pediatrics; Moll I, Marcellis RGJ et. al.

Jan 15th, 2022 - Spastic cerebral palsy is the most common cause of motor disability in children. It often leads to foot drop or equinus, interfering with walking. Ankle-foot orthoses (AFOs) are commonly used in these cases. However, AFOs can be too restrictive for mildly impaired patients. Functional electrical stimulation (FES) of the ankle-dorsiflexors is an alternative treatment as it could function as a dy...

A randomised controlled trial on roles of prostaglandin E1 nebulization among patients ...
https://doi.org/10.1186/s12890-022-01831-4 10.3945/an.116.012211 10.3322/caac.21492 10.1053/j.jvca.2017.12.026 10.4103/0019-5049.165855 10.1097/ALN.0000000000003720 10.1186/s12974-017-1051-y 10.3390/jcm8070982 10.1177/1089253208319869 10.21037/atm.2017.10.15 10.1007/s12630-014-0246-2 10.1111/j.1365-2044.1996.tb07783.x 10.1186/1745-6215-15-486 10.4103/2045-8932.109931 10.1186/s12931-019-1261-1 10.1089/jamp.2010.0858 10.1164/rccm.201010-1584CI 10.1093/bja/81.3.327 10.1164/ajrccm/143.5_Pt_1.1121 10.1378/chest.09-2293 10.21037/atm-20-4895 10.1097/ALN.0000000000000569 10.1097/ALN.0b013e31819fb15d 10.1016/j.jtcvs.2007.05.003 10.1016/j.intimp.2016.04.021 10.1042/BSR20190597
BMC Pulmonary Medicine; Li P, Gu L et. al.

Jan 15th, 2022 - Prostaglandin E1 (PGE1) has been reported to maintain adequate oxygenation among patients under 60% FiO2 one-lung ventilation (OLV). This research aimed to explore whether PGE1 is safe in pulmonary shunt and oxygenation under 40% FiO2 OLV and provide a reference concentration of PGE1. Totally 90 esophageal cancer patients treated with thoracotomy were enrolled in this study, randomly divided in...

Quantitative comparison of SARS-CoV-2 nucleic acid amplification test and antigen testi...
https://doi.org/10.1186/s12889-021-12489-8 10.15585/mmwr.mm695152a3 10.15585/mmwr.mm7003e3 10.1093/cid/ciab110 10.1016/S2468-2667(21)00002-5 10.1038/s41598-021-94055-1 10.7326/M20-1495 10.2807/1560-7917.ES.2020.25.32.2001483
BMC Public Health; Salvatore PP, Shah MM et. al.

Jan 15th, 2022 - Antigen tests for SARS-CoV-2 offer advantages over nucleic acid amplification tests (NAATs, such as RT-PCR), including lower cost and rapid return of results, but show reduced sensitivity. Public health organizations recommend different strategies for utilizing NAATs and antigen tests. We sought to create a framework for the quantitative comparison of these recommended strategies based on their...

Clinical significance of metabolism-related genes and FAK activity in ovarian high-grad...
https://doi.org/10.1186/s12885-021-09148-x
BMC Cancer; Sato M, Sato S et. al.

Jan 15th, 2022 - Administration of poly (ADP-ribose) polymerase (PARP) inhibitors after achieving a response to platinum-containing drugs significantly prolonged relapse-free survival compared to placebo administration. PARP inhibitors have been used in clinical practice. However, patients with platinum-resistant relapsed ovarian cancer still have a poor prognosis and there is an unmet need. The purpose of this...

National strategy for palliative care of severely ill and dying people and their relati...
https://doi.org/10.1186/s12904-021-00898-w 10.1007/s00482-020-00483-9 10.1016/S0140-6736(20)30964-8 10.1055/a-1156-2759 10.1016/j.jpainsymman.2020.03.029 10.1016/j.jpainsymman.2020.04.015 10.1177/0269216320920780 10.1016/j.jpainsymman.2020.04.153 10.1016/j.jpainsymman.2020.06.008 10.1002/pon.842 10.1037/0022-3514.54.6.1063 10.1186/s12955-020-01473-2 10.1136/bmjspcare-2013-000596 10.1007/978-3-658-18755-2 10.1016/j.jpainsymman.2020.04.024 10.1177/0030222820966928 10.3389/fpsyt.2020.00489 10.1016/S0140-6736(17)30978-9 10.1016/S0140-6736(17)32513-8
BMC Palliative Care; Bausewein C, Hodiamont F et. al.

Jan 15th, 2022 - In the SARS-CoV-2 pandemic, general and specialist Palliative Care (PC) plays an essential role in health care, contributing to symptom control, psycho-social support, and providing support in complex decision making. Numbers of COVID-19 related deaths have recently increased demanding more palliative care input. Also, the pandemic impacts on palliative care for non-COVID-19 patients. Strategie...

Cell-free DNA methylation markers for differential diagnosis of hepatocellular carcinoma.
https://doi.org/10.1186/s12916-021-02201-3 10.1002/hep.26898 10.1002/hep.25670 10.1002/hep.24199 10.1053/j.gastro.2009.04.005 10.1002/hep.24199 10.1016/j.cgh.2010.09.017 10.3748/wjg.v21.i37.10573 10.1053/jhep.2002.32525 10.1371/journal.pone.0151501 10.1126/scitranslmed.3007094 10.1158/2159-8290.CD-17-0716 10.1126/science.aar3247 10.1038/nrc3130 10.1038/ng.298 10.1073/pnas.96.15.8681 10.1073/pnas.1313995110 10.1038/cr.2015.126 10.1038/s41551-021-00746-5 10.1111/cas.13314 10.1002/cncr.32876 10.1038/nature22364 10.1016/j.annonc.2020.02.011 10.1136/gutjnl-2019-318882 10.3322/caac.21551
BMC Medicine; Luo B, Ma F et. al.

Jan 15th, 2022 - Aberrant DNA methylation may offer opportunities in revolutionizing cancer screening and diagnosis. We sought to identify a non-invasive DNA methylation-based screening approach using cell-free DNA (cfDNA) for early detection of hepatocellular carcinoma (HCC). Differentially, DNA methylation blocks were determined by comparing methylation profiles of biopsy-proven HCC, liver cirrhosis, and norm...

MicroRNA-625-3p improved proliferation and involved chemotherapy resistance via targeti...
https://doi.org/10.1186/s13048-021-00939-1 10.1016/j.bbagen.2018.11.005 10.3390/ijerph16091510 10.1016/j.biopha.2018.03.043 10.1186/s13048-019-0484-6 10.1016/j.molmed.2014.06.005 10.1097/JTO.0b013e3182572e83 10.1038/srep41330 10.3892/ijmm_00000530 10.1186/s12943-016-0536-0 10.15252/embr.201948483 10.1016/j.molonc.2013.02.016 10.1038/bjc.2013.795 10.3389/fgene.2018.00555 10.1186/s13148-018-0587-8 10.1016/j.bbrc.2016.11.037 10.1097/PAP.0b013e3181b4fffa 10.1186/s13048-019-0482-8 10.1038/s41419-018-0390-7 10.1186/s13046-019-1171-6 10.7150/jca.41135 10.1016/j.omto.2018.12.002 10.1186/s13048-019-0576-3 10.1158/0008-5472.CAN-07-2488
Journal of Ovarian Research; Zhong L, Liu X et. al.

Jan 15th, 2022 - High-grade serous ovarian cancer (HGSOC) is an aggressive gynaecological malignancy and associated with poor prognosis. Here we examined the effects of miR-625-3p on proliferation, treatment, migration and invasion in HGSOC. The proliferation of HGSOC cells was evaluated by MTT assay. Transwell assay was performed to examine migration and matrigel assay were used to assess invasion. The effect ...

Larval habitats, species composition and distribution of malaria vectors in regions wit...
https://doi.org/10.1186/s12936-021-04033-1
Malaria Journal; de Almeida NCV, Louzada J et. al.

Jan 15th, 2022 - Malaria control requires local action. Assessing the vector diversity and abundance provides information on the local malariogenic potential or risk of transmission. This study aimed to determine the Anopheles species composition, habitats, seasonal occurrence, and distribution in areas with autochthonous and imported malaria cases in Roraima State. A longitudinal study was conducted from Janua...

Primary low-grade extrauterine endometrial stromal sarcoma: analysis of 10 cases with a...
https://doi.org/10.1186/s12957-021-02474-1 10.1136/jclinpath-2014-202829 10.1097/00004347-199310000-00002 10.3346/jkms.2009.24.3.529 10.1080/136518202753598735 10.1159/000336522 10.1097/PAS.0000000000000083 10.1016/j.anndiagpath.2004.07.007 10.1016/j.ijgo.2015.06.006 10.1016/S0090-8258(03)00207-5 10.1097/MD.0000000000006584 10.1136/jclinpath-2015-202915 10.1016/j.anndiagpath.2018.06.004 10.1097/PGP.0b013e318064511c 10.1007/s10147-011-0299-y 10.1097/AOG.0b013e31818aa89a 10.1038/sj.bjc.6604527 10.1097/PAS.0000000000000256 10.1097/01.AOG.0000185511.91694.1e 10.22074/ijfs.2020.44413 10.1097/PAS.0000000000000145 10.18632/oncotarget.18805 10.1016/j.ygyno.2007.01.031 10.1111/IGC.0b013e3181b33c9a
World Journal of Surgical Oncology; Wu Y, Li N et. al.

Jan 15th, 2022 - This study aimed to analyze the clinical and pathological features of extrauterine endometrial stromal sarcoma (EESS) and explore an effective therapeutic regimen to reduce the recurrence rate in low-grade EESS patients. Ten LG-EESS patients who were treated at the Chinese Academy of Medical Sciences Cancer Institute and Hospital from June 1999 to June 2019 were collected and analyzed. (1) Pati...

Masked diabetes insipidus in pituitary metastasis from breast cancer after thalamic bio...
https://doi.org/10.1186/s13256-021-03229-y 10.1530/EC-18-0338 10.1007/s11102-018-0899-x 10.12659/AJCR.928113 10.1136/bcr-2014-203683 10.12659/AJCR.901032 10.1007/s11102-014-0552-2 10.1007/s11060-020-03396-w 10.1530/eje.1.02326 10.1634/theoncologist.2019-0520 10.1007/s11102-006-8326-0 10.1007/s11102-021-01159-y 10.1007/s00234-018-2072-7 10.4997/JRCPE.2017.307 10.1007/s11102-013-0542-9 10.3171/2014.12.JNS14870 10.2176/nmc.44.112 10.1016/j.surneu.2008.06.003 10.1227/NEU.0b013e3182351ae7
Journal of Medical Case Reports; Hashimoto H, Maruo T et. al.

Jan 15th, 2022 - Symptomatic pituitary metastasis is rare; furthermore, it can result in diabetes insipidus and panhypopituitarism. Since diabetes insipidus is masked by concurrent panhypopituitarism, it can impede the diagnosis of pituitary dysfunction. A 68-year-old Japanese female suffering from pituitary and thalamic metastases caused by untreated breast cancer, underwent a biopsy targeting the thalamus, no...

Implementation of SARS-CoV-2 monoclonal antibody infusion sites at three medical center...
https://doi.org/10.1017/dmp.2022.15
Disaster Medicine and Public Health Preparedness; Lambrou AS, Redd JT et. al.

Jan 15th, 2022 - Monoclonal antibody therapeutics to treat COVID-19 have been authorized by the U.S. Food and Drug Administration under Emergency Use Authorization (EUA). Many barriers exist when deploying a novel therapeutic during an ongoing pandemic, and it is critical to assess the needs of incorporating monoclonal antibody infusions into pandemic response activities. We examined the monoclonal antibody inf...

Long-term outcomes in pediatric patients who underwent living donor liver transplantati...
https://doi.org/10.1016/j.surg.2021.11.027
Surgery Sanada Y, Sakuma Y et. al.

Jan 15th, 2022 - There is no consensus about long-term outcomes in patients with biliary atresia. We retrospectively reviewed the long-term outcomes in pediatric patients who underwent living donor liver transplantation for biliary atresia. Between May 2001 and December 2020, 221 (73%) of 302 pediatric patients who underwent living donor liver transplantation had biliary atresia. The median age at living donor ...

Combined Norwood and cavopulmonary shunt as the first palliation in late presenters wit...
https://doi.org/10.1016/j.jtcvs.2021.10.061
The Journal of Thoracic and Cardiovascular Surgery; Elmahrouk AF, Ismail MF et. al.

Jan 15th, 2022 - A primary cavopulmonary shunt as a component of the initial Norwood palliation could be an option in patients with hypoplastic left heart syndrome and single-ventricle lesions. We present our initial experience with this approach in carefully selected patients with unrestricted pulmonary blood flow and low pulmonary vascular resistance. The study included 16 patients; the mean age was 137.9 ± 8...

The effect of frailty on post-operative outcomes and health care expenditures in patien...
https://doi.org/10.1016/j.ejso.2022.01.001
European Journal of Surgical Oncology : the Journal of Th... Rosiello G, Re C et. al.

Jan 15th, 2022 - To examine the effect of frailty on short-term post-operative outcomes and total hospital charges (THCs) in patients with non-metastatic renal cell carcinoma, treated with partial nephrectomy (PN). Within the National Inpatient Sample (NIS) database we identified 25,545 patients treated with PN from 2000 to 2015. We used the Johns Hopkins Adjusted Clinical Groups (ACG) frailty-defining indicato...

Enthesitis in patients with psoriatic arthritis and axial spondyloarthritis - data from...
https://doi.org/10.1016/j.semarthrit.2021.12.012
Seminars in Arthritis and Rheumatism; Mathew AJ, Glintborg B et. al.

Jan 15th, 2022 - To explore the registration, pattern and burden of clinical enthesitis among routine-care patients with psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) in the Danish nationwide DANBIO registry. In patients with PsA and axSpA in DANBIO, prospectively registered data from 2010 to 2020 on clinical entheseal assessment using SPARCC score were compared with demographic, clinical and pa...

Impact of the number of comorbidities on the outcome measures and on the retention rate...
https://doi.org/10.1016/j.semarthrit.2021.12.007
Seminars in Arthritis and Rheumatism; Puche-Larrubia MÁ, Ladehesa-Pineda L et. al.

Jan 15th, 2022 - To evaluate the impact of the number of comorbidities on the outcome measures after two years of follow-up in patients with Ankylosing Spondylitis (AS) and to determine whether the number of comorbidities influences the retention rate of the first anti-TNF. This was an observational and prospective study conducted during 2 years of follow-up in the REGISPONSER-AS registry. The patients were div...

Abdominal aortic aneurysm and gas in the kidney in a diabetes patient.
https://doi.org/10.1016/j.ejim.2022.01.001
European Journal of Internal Medicine; Liu Y, Ren M et. al.

Jan 15th, 2022 - Abdominal aortic aneurysm and gas in the kidney in a diabetes patient.|2022|Liu Y,Ren M,Huang Y,|

Surgical outcomes for older patients with renal cell carcinoma and inferior vena cava t...
https://doi.org/10.1016/j.urolonc.2021.12.013
Urologic Oncology; Ishiyama Y, Kondo T et. al.

Jan 15th, 2022 - To compare the surgical and oncological outcomes of older patients undergoing surgery for renal cell carcinoma (RCC) with a tumor in the inferior vena cava (IVC) and those of younger patients. We retrospectively evaluated 123 patients who underwent surgery for RCC-IVC at two institutions between 2008 and 2019. We classified them into the ≥70 years and the <70 years group, based on their age dur...

DNA methylation episignature in Gabriele-de Vries syndrome.
https://doi.org/10.1016/j.gim.2021.12.003
Genetics in Medicine : Official Journal of the American C... Cherik F, Reilly J et. al.

Jan 15th, 2022 - Gabriele-de Vries syndrome (GADEVS) is a rare genetic disorder characterized by developmental delay and/or intellectual disability, hypotonia, feeding difficulties, and distinct facial features. To refine the phenotype and to better understand the molecular basis of the syndrome, we analyzed clinical data and performed genome-wide DNA methylation analysis of a series of individuals carrying a Y...

Fluorescent molecular imaging can improve intraoperative sentinel margin detection in o...
https://doi.org/10.2967/jnumed.121.262235
Journal of Nuclear Medicine : Official Publication, Socie... Krishnan G, van den Berg NS et. al.

Jan 15th, 2022 - Rationale: In head and neck cancer, a major limitation of current intraoperative margin analysis is the ability to detect areas most likely to be positive based on specimen palpation, especially for larger specimens where sampling error limits detection of positive margins. This study aims to prospectively examine the clinical value of fluorescent molecular imaging to accurately identify "the s...