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About 1,680,008 results

Germline Variants Identified in Patients with Early-onset Renal Cell Carcinoma Referred for Germline Genetic Testing
https://pubmed.ncbi.nlm.nih.gov/34654685/
European Urology Oncology; Truong H

Oct 12th, 2021 - Despite guidelines recommending genetic counseling for patients with early-onset renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations and clinical associations in patients with early-onset RCC are lacking.

Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants
https://www.biorxiv.org/content/10.1101/2021.07.19.452771v1
BioRxiv Tada T, Zhou H et. al.

Jul 19th, 2021 - The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible decreases in vaccine efficacy. Here, neutralizing antibody titers elicited by mRNA-based and an adenoviral vector-based vaccine against variant pseudotyped viruses were compared.

DSHS Statement on Monkeypox Investigation
https://www.dshs.texas.gov/news/releases/2021/20210716.aspx
Texas Health and Human Services

Jul 16th, 2021 - The Texas Department of State Health Services is working with Dallas County Health and Human Services and the CDC to investigate a single case of monkeypox virus infection in a Dallas County resident who recently returned from Nigeria. The patient is isolated in the hospital, and the public health investigation has identified a few people who may have been exposed in Dallas and are monitoring t...

CDC and Texas Confirm Monkeypox In U.S. Traveler
https://www.cdc.gov/media/releases/2021/s0716-confirm-monkeypox.html
Centers for Disease Control and Prevention (CDC)

Jul 16th, 2021 - The Centers for Disease Control and Prevention (CDC) and the Texas Department of State Health Services confirmed on July 15 a case of human monkeypox in a U.S. resident who recently traveled from Nigeria to the United States. The person is currently hospitalized in Dallas. CDC is working with the airline and state and local health officials to contact airline passengers and others who may have ...

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report
https://www.medrxiv.org/content/10.1101/2021.10.10.21264827v1.full.pdf
Medrxiv Atmar RL, .

Oct 13th, 2021 - Background: While Coronavirus disease 2019 (Covid-19) vaccines are highly effective, breakthrough infections are occurring. Booster vaccinations have recently received emergency use authorization (EUA) for certain populations but are restricted to homologous mRNA vaccines. We evaluated homologous and heterologous booster vaccination in persons who had received an EUA Covid-19 vaccine regimen.

Continuous-Release Anti-VEGF Device for AMD Wins FDA Approval
https://www.medpagetoday.com/ophthalmology/generalophthalmology/95225

Oct 23rd, 2021 - The FDA has approved a first-of-its kind continuous delivery system for anti-VEGF therapy for neovascular (wet) age-related macular degeneration (AMD). The Susvimo ocular implant continuously releases 100 mg/mL of ranibizumab directly to the retina over 6 months. Initial implantation and refill can be performed during an office visit with an ophthalmologist. In contrast, conventional intravitre...

Impact of Transcatheter Mitral Valve Repair on Preprocedural and Postprocedural Hospita...
https://doi.org/10.1016/j.jcin.2021.08.007
JACC. Cardiovascular Interventions; Czarnecki A, Han L et. al.

Oct 23rd, 2021 - The objective of this study was to determine the effect of transcatheter mitral valve repair (TMVr) on hospitalization rates by assessing pre- and postprocedural hospitalization patterns. TMVr has emerged as the treatment of choice for selected patients with mitral regurgitation, but the impact of these procedures on hospital utilization remains unclear. All patients who underwent TMVr in Ontar...

Prognostic indicators and outcomes following surgical management of metastatic cutaneou...
https://doi.org/10.1016/j.bjoms.2021.01.003
The British Journal of Oral & Maxillofacial Surgery; O'Connell JE, Saeed A et. al.

Oct 23rd, 2021 - Metastatic cutaneous SCC carries a poor prognosis with five-year survival of 25%-57%. The aim of this study is to examine the outcomes following surgery with adjuvant therapy for management of metastatic cSCC in a UK-based population. This is a retrospective review of patients with metastatic cSCC of the head and neck who underwent primary surgery at a regional center during a six-year period. ...

Functional outcomes after submandibular gland-sparing neck dissection in patients with ...
https://doi.org/10.1016/j.ijom.2021.09.009
International Journal of Oral and Maxillofacial Surgery; Gu H, Xuan G et. al.

Oct 23rd, 2021 - The feasibility of submandibular gland (SMG) preservation during neck dissection has been described. The aim of this study was to analyse the functional outcomes in patients undergoing SMG preservation during neck dissection for cT1-2N0 oral squamous cell carcinoma. Consecutive patients were divided into two groups based on the management of the SMG, and underwent a saliva flow test before surg...

Is treating severe He FH so easy? A combined treatment between lipoprotein apheresis an...
https://doi.org/10.1016/j.transci.2021.103258
Transfusion and Apheresis Science : Official Journal of T... Dal Pino B, Sbrana F et. al.

Oct 23rd, 2021 - Despite advance in pharmacotherapy of lipid disorders, many heterozygous Familial Hypercholesterolemia patients do not achieve a desirable lipid target to significantly reduce the risk of atherosclerotic cardiovascular disease. The aim of the present work is to evaluate the interaction between Lipoprotein apheresis (LA) and PCSK9i in a small FH cohort in which the guidelines therapeutic target ...

Improvements in Health-related Quality of Life and Symptoms in Patients With Previously...
https://doi.org/10.1016/j.clml.2021.09.008
Clinical Lymphoma, Myeloma & Leukemia; Danilov AV, Yimer HA et. al.

Oct 23rd, 2021 - We evaluated health-related quality of life (HRQoL) in patients with chronic lymphocytic leukemia (CLL) receiving first-line chemoimmunotherapy in the GIBB single-arm, Phase II study of obinutuzumab plus bendamustine (BG). Patients received six 28-day cycles of BG and were followed for up to 27 months. HRQoL was assessed using the European Organization for Research and Treatment of Cancer Quali...

Prognostic of Core Binding Factor (CBF) Acute Myeloid Leukemia With Complex Karyotype.
https://doi.org/10.1016/j.clml.2021.09.007
Clinical Lymphoma, Myeloma & Leukemia; Marcault C, Boissel N et. al.

Oct 23rd, 2021 - Core-binding factor acute myeloid leukemia (CBF AML) with recurrent genetic abnormalities inv(16)(p13.1q22) or t(16;16)(p13.1;q22)/ CBFB-MYH11 are usually prognostically favorable but heterogeneous group and additional abnormalities change their prognosis. To evaluate the impact of a complex karyotype on CBF AML prognosis, we included 24 patients with a median age of 56.4 years (23.2-83.3) and ...

Injectable Hypomethylating Agents for Management of Myelodysplastic Syndromes: Patients...
https://doi.org/10.1016/j.clml.2021.09.009
Clinical Lymphoma, Myeloma & Leukemia; Zeidan AM, Jayade S et. al.

Oct 23rd, 2021 - Until recently, patients with MDSs could receive HMAs via intravenous (IV) or subcutaneous (SC) administration. An oral HMA was recently approved as an alternative to IV/SC administration. This study assessed the impact of IV/SC HMA on MDS patients, and their experience of, challenges with, and views about oral MDS treatment. We conducted an online cross-sectional survey among adult MDS patient...

Bing-Neel Syndrome: Update on the Diagnosis and Treatment.
https://doi.org/10.1016/j.clml.2021.09.014
Clinical Lymphoma, Myeloma & Leukemia; Nanah A, Al Hadidi S

Oct 23rd, 2021 - Bing-Neel syndrome (BNS) is a rare syndrome that occurs in patients with Waldenstrom macroglobulinemia and is characterized by lymphoplasmacytic infiltration into the leptomeningeal tissue and/or the central nervous system. It represents an extramedullary manifestation which may translate into various neurological symptoms. Accurate diagnosis of BNS can be established via histologic sampling an...

Changes in Ventricular and Cortical Volumes following Shunt Placement in Patients with ...
https://doi.org/10.3174/ajnr.A7323
AJNR. American Journal of Neuroradiology; Cogswell PM, Murphy MC et. al.

Oct 23rd, 2021 - While changes in ventricular and extraventricular CSF spaces have been studied following shunt placement in patients with idiopathic normal pressure hydrocephalus, regional changes in cortical volumes have not. These changes are important to better inform disease pathophysiology and evaluation for copathology. The purpose of this work is to investigate changes in ventricular and cortical volume...

Anatomic Neuroimaging Characteristics of Posterior Fossa Type A Ependymoma Subgroups.
https://doi.org/10.3174/ajnr.A7322
AJNR. American Journal of Neuroradiology; Sabin ND, Hwang SN et. al.

Oct 23rd, 2021 - Posterior fossa type A (PFA) ependymomas have 2 molecular subgroups (PFA-1 and PFA-2) and 9 subtypes. Gene expression profiling suggests that PFA-1 and PFA-2 tumors have distinct developmental origins at different rostrocaudal levels of the brainstem. We, therefore, tested the hypothesis that PFA-1 and PFA-2 ependymomas have different anatomic MR imaging characteristics at presentation. Two neu...

European Glaucoma Society Terminology and Guidelines for Glaucoma, 5th Edition.
https://doi.org/10.1136/bjophthalmol-2021-egsguidelines
The British Journal of Ophthalmology;

Oct 23rd, 2021 - The only time is now. Every "now" is unique. Responsible persons ask themselves, "How can I act well now?" The answers will differ for every person, because just as every situation is unique, so is every person different from every other person. But surely there must be some algorithm that will assist us in coming to the right answer. Unfortunately, no, for there is no right answer. There is on...

Teaching Video NeuroImage: Carbamazepine Improves Gait Initiation in Autosomal Recessiv...
https://doi.org/10.1212/WNL.0000000000013010
Neurology Fuseya Y, Ishikawa N et. al.

Oct 23rd, 2021 - Teaching Video NeuroImage: Carbamazepine Improves Gait Initiation in Autosomal Recessive Myotonia Congenita.|2021|Fuseya Y,Ishikawa N,Sasaki R,Yamashita H,|

Arcuate nucleus overexpression of NHLH2 reduces body mass and attenuates obesity-associ...
https://doi.org/10.1523/JNEUROSCI.0222-21.2021
The Journal of Neuroscience : the Official Journal of The... Carraro RS, Nogueira GA et. al.

Oct 23rd, 2021 - Nescient helix-loop-helix 2 (NHLH2) is a hypothalamic transcription factor that controls the expression of prohormone convertase 1/3, therefore having an impact on the processing of proopiomelanocortin and thus on energy homeostasis. Studies have shown that knockout of Nhlh2 results in increased body mass, reduced physical activity and hypogonadism. In humans, a polymorphism of the NHLH2 gene i...