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About 1,680,508 results

Acceptability of hygiene, face covering and social distancing interventions to prevent ...
https://doi.org/10.1136/thoraxjnl-2021-217981
Thorax Hurst JR, Cumella A et. al.

Oct 23rd, 2021 - Interventions to prevent the spread of SARS-CoV-2 have been associated with substantial reductions in exacerbations of airways diseases, likely through reduced transmission of other respiratory viruses. We surveyed 4442 people with airways disease (asthma=3627, bronchiectasis=258, chronic obstructive pulmonary disease=557) to gauge attitudes and intentions towards continuing such measures after...

Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study.
https://doi.org/10.1136/thoraxjnl-2021-217870
Thorax Nathan N, Montagne ME et. al.

Oct 23rd, 2021 - Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients' indirect exposure to inorganic particles, through coresidents' occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5-7) vs 0.5 (0-2), p=0.003 and...

Variation of Patent Ductus Arteriosus Treatment in Very Low Birth Weight Infants.
https://doi.org/10.1542/peds.2021-052874
Pediatrics Runte KE, Flyer JN et. al.

Oct 23rd, 2021 - Patent ductus arteriosus (PDA) treatment is common among very low birth weight (VLBW) infants. Given limitations in evidence, controversy exists regarding treatment risks and benefits. In this study, we describe PDA treatment trends and variation in a large, US, multicenter VLBW infant cohort. Data were collected through Vermont Oxford Network on 291 292 VLBW infants born 2012-2019 at 806 US NI...

New treatment algorithm for keratoconus and cataract: small-aperture IOL insertion with...
https://doi.org/10.1097/j.jcrs.0000000000000642
Journal of Cataract and Refractive Surgery; Northey LC, Holland SP et. al.

Oct 23rd, 2021 - To describe a new treatment algorithm aimed at optimizing refractive outcomes for patients with keratoconus and cataract. Private practice in Sydney, Australia. Retrospective case series. This procedural approach involves cataract extraction with small-aperture intraocular lens (IOL) insertion, IC-8 IOL (AcuFocus, Inc.), followed by topography-guided photorefractive keratectomy (T-PRK) with sim...

Accuracy of IOL power calculation formulas in Marfan lens subluxation patients with in-...
https://doi.org/10.1097/j.jcrs.0000000000000649
Journal of Cataract and Refractive Surgery; Zhang M, Chen T et. al.

Oct 23rd, 2021 - To investigate the accuracy of intraocular lens (IOL) formulas for the prediction of postoperative refraction in lens subluxation in Marfan syndrome. Eye and ENT Hospital of Fudan University, Shanghai, China. Consecutive retrospective clinical observational case series. 60 eligible eyes with lens subluxation from 39 young patients with Marfan syndrome (8.53 ± 4.38 years) underwent phacoemulsifi...

Nuclear cataract, moderate oblique corneal astigmatism, and glaucoma in a highly myopic...
https://doi.org/10.1097/j.jcrs.0000000000000835
Journal of Cataract and Refractive Surgery; Menapace R

Oct 23rd, 2021 - A 65-year-old woman had undergone bilateral foldable iris-fixated phakic intraocular lens (pIOL) implantation in 2008 to correct for high myopia of -10 diopters (D). 12 years later, she presented with nuclear and subcortical cataract in her right eye. The Artiflex pIOL (Figure 1JOURNAL/jcrs/04.03/02158034-202111000-00021/figure1/v/2021-10-20T185516Z/r/image-tiff) was well centered and fixed to ...

Intracellular delivery of protein drugs with an autonomously lysing bacterial system re...
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Nature Communications; Raman V, Van Dessel N et. al.

Oct 23rd, 2021 - Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell membranes. Here we report the development of a Salmonella-based intracellular delivery system to address this challenge. We engineer genetic circuits that (1) activate the regulator flhDC to drive invasion and (2) induce lysis to release proteins into tumor cells. Released protein drugs diffuse from Sa...

The Characteristics of Power Spectral Density in Bipolar Disorder at the Resting State.
https://doi.org/10.1177/15500594211050487
Clinical EEG and Neuroscience; Sunaga M, Takei Y et. al.

Oct 23rd, 2021 - Bipolar disorder (BD) is a common psychiatric disorder, but its pathophysiology is not fully elucidated. The current study focused on its electrophysiological characteristics, especially power spectral density (PSD). Resting state with eyes opened magnetoencephalography data were collected from 21 patients with BD and 22 healthy controls. The whole brain's PSD was calculated from source reconst...

Association between toxic organochlorine levels in human serum and systemic lupus eryth...
https://doi.org/10.1177/09612033211051947
Lupus Helmy MA, Saad-Hussein A et. al.

Oct 23rd, 2021 - Organochlorines (OCs) are groups of highly toxic pesticides with known immunotoxicity. The present work aimed to study the potential association between serum residues of OCs and the risk of developing systemic lupus erythematosus (SLE) as well as correlating to the clinical-laboratory manifestations in a sample of Egyptian SLE patients. A cross-sectional study was conducted on 132 patients env...

Esophageal cancer mutational signatures around the world.
https://doi.org/10.1038/s41588-021-00958-0 10.1016/j.cell.2013.03.002 10.1038/nature12477 10.1016/j.cell.2019.03.001 10.1038/s41588-021-00928-6 10.1038/s41586-020-1943-3 10.1136/gutjnl-2019-320462 10.1038/s41586-020-2080-8 10.1158/2159-8290.CD-20-1656 10.1053/j.gastro.2017.08.023 10.1053/j.gastro.2018.12.024 10.1038/ncomms6135 10.1038/s41588-020-0692-4 10.1093/aje/kwaa234 10.1038/s41586-019-1672-7 10.1126/science.aao3130
Nature Genetics; Giannakis M, Peters U

Oct 23rd, 2021 - Esophageal cancer mutational signatures around the world.|2021|Giannakis M,Peters U,|

Accurately Controlled Delivery of Temozolomide by Biocompatible UiO-66-NH2 Through Ultr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517532
International Journal of Nanomedicine; Wan Z, Li C et. al.

Oct 23rd, 2021 - Glioma is the most common and malignant primary brain tumour in adults and has a dismal prognosis. Temozolomide (TMZ) is the only clinical first-line chemotherapy drug for malignant glioma up to present. Due to poor aqueous solubility and toxic effects, TMZ is still inefficient and limited for clinical glioma treatment. UiO-66-NH2 nanoparticle is a zirconium-based framework, constructed by Zr a...

Sodium Butyrate Alleviates Intestinal Inflammation in Mice with Necrotizing Enterocolitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526205
Mediators of Inflammation; Sun Q, Ji YC et. al.

Oct 23rd, 2021 - To determine the role of sodium butyrate in intestinal inflammation via regulation of high-mobility group box-1 (HMGB1), we analyzed the potential mechanism in necrotizing enterocolitis (NEC) in a neonatal mouse model. A NEC model was created with hypoxia and cold exposure and artificial overfeeding. C57BL/6 neonatal mice were randomized into three groups: the control, untreated NEC, and sodium...

Intraarterial Lidocaine Administration for Pain Control by Water-in-Oil Technique in Tr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502067
Journal of Hepatocellular Carcinoma; Wang LZ, Hu XX et. al.

Oct 23rd, 2021 - To investigate the sustained release of lidocaine from a lidocaine-epirubicin-lipiodol emulsion created by water-in-oil (W/O) technique in vivo and evaluate the efficacy and safety of intraarterial lidocaine administration for intra- and postoperative pain control in transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). The in vivo concentrations of lidocaine were determine...

Lenvatinib Combined with Anti-PD-1 Antibodies Plus Transcatheter Arterial Chemoemboliza...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502053
Journal of Hepatocellular Carcinoma; Wu JY, Yin ZY et. al.

Oct 23rd, 2021 - Lenvatinib (LEN) combined with anti-PD-1 antibodies (PD-1) exerted promising effects on unresectable hepatocellular carcinoma (uHCC). We assessed the safety and clinical efficacy of triple therapy [LEN+PD-1+transcatheter arterial chemoembolization (TACE)] in uHCC. uHCC patients with an ECOG PS score of 0-1 and Child-Pugh class A who underwent triple therapy were included. The primary endpoint w...

Predictive factors associated with induction-related death in acute myeloid leukemia in...
https://doi.org/10.1007/s00277-021-04687-6 10.1182/blood.2019001239 10.1080/10428194.2020.1827252 10.1002/cncr.29319 10.1182/bloodadvances.2020001728 10.1080/10428190600627055 10.1016/j.leukres.2017.07.005 10.1016/S0140-6736(10)62105-8 10.1111/bjh.14631 10.1182/bloodadvances.2019001419 10.1016/j.jbi.2008.08.010 10.1002/cncr.31296 10.1182/blood-2016-08-733196 10.1016/0021-9681(87)90171-8 10.1038/sj.bmt.1705727 10.1016/S0167-7152(96)00128-9 10.1371/journal.pone.0176231 10.1182/bloodadvances.2020003806 10.3389/fmicb.2020.01422 10.1371/journal.pone.0210991 10.1016/j.leukres.2015.02.003 10.1097/MD.0000000000004182 10.1002/cncr.26273 10.1080/10428190701809172 10.1007/s11899-007-0014-2 10.1200/JCO.18.00374 10.1007/s11912-017-0574-9 10.1182/blood-2019-123435 10.1002/cncr.21723 10.3324/haematol.13309 10.1200/JCO.2011.35.7525 10.1016/j.clml.2019.12.015
Annals of Hematology; Mendes FR, da Silva WF et. al.

Oct 23rd, 2021 - Despite advances in supportive measures, acute myeloid leukemia (AML) remission induction still has a high mortality rate in real-world studies as compared to prospective reports. We analyzed data from 206 AML adult patients treated with conventional chemotherapy. The primary endpoint was the 60-day mortality rate, aiming to find risk factors and to examine the role of anti-infection prophylaxi...

Psychiatric, Substance Use, and Structural Disparities Between Gay and Bisexual Men wit...
https://doi.org/10.1007/s10508-021-02037-1 10.1007/s10461-005-9000-7 10.1080/00224490802204431 10.1177/0886260510372946 10.1007/s00127-014-0849-5 10.1037/ccp0000251 10.1111/cpsp.12098 10.1007/s10508-015-0546-9 10.2105/AJPH.2008.152942 10.1080/08964289.2014.889069 10.1089/lgbt.2018.0207 10.1016/j.addbeh.2009.12.019 10.1016/j.brat.2006.08.018 10.1016/S0140-6736(98)07026-3 10.1016/j.socscimed.2015.01.018 10.1007/978-3-319-71535-3_6 10.1007/s11524-013-9811-1 10.1037/a0034223 10.1086/382250 10.1007/s11930-017-0096-3 10.1016/j.cbpra.2017.10.003 10.1016/s0749-3797(98)00017-8 10.1001/jamapediatrics.2013.42 10.1016/j.janxdis.2011.12.001 10.1002/da.20284 10.1007/s00127-016-1208-5 10.1007/s13524-015-0406-1 10.1037/a0025424 10.1007/s10461-008-9432-y 10.1016/j.beth.2019.09.001 10.2105/AJPH.2009.168815 10.2105/AJPH.2012.301069 10.1177/1524838010386812 10.1037/sgd0000314 10.1016/j.drugalcdep.2016.10.038 10.1001/archpsyc.62.6.617 10.1097/01.psy.0000188405.54425.20 10.1017/S0033291797006508 10.1097/00006842-199703000-00007 10.1016/j.jadohealth.2011.02.005 10.1111/j.1360-0443.2008.02149.x 10.2105/AJPH.2007.127811 10.1111/j.1360-0443.2009.02596.x 10.1007/s00439-012-1168-0 10.1093/aje/152.2.99 10.1037/0033-2909.129.5.674 10.1177/0013164487472028 10.1097/QAI.0b013e3181a24b38 10.1080/09540121.2019.1595518 10.2105/AJPH.2013.301744 10.2105/AJPH.2009.178319 10.1037/a0039077 10.1111/j.1399-5618.2008.00589.x 10.1002/jts.21767 10.1097/QAI.0b013e31824aed80 10.1007/s10461-019-02482-z 10.1111/cpsp.12078 10.1177/0886260514540802 10.1016/j.cpr.2009.02.007 10.3109/09540261.2015.1083949 10.2105/AJPH.2009.168971 10.2105/AJPH.2011.300530 10.1037/1099-9809.10.3.215 10.1080/00224499.2017.1387755 10.1017/S0033291707001699 10.1038/mp.2008.94 10.2105/ajph.93.9.1552 10.1007/s10508-018-1150-6 10.1177/1534765610395614 10.1126/science.280.5365.867 10.1007/s10508-018-1254-z 10.1016/j.comppsych.2013.11.016 10.1016/j.jocrd.2017.07.001 10.1037/ort0000285 10.1016/0747-5632(85)90017-2 10.1007/s11524-014-9871-x 10.1080/10538712.2015.1006746
Archives of Sexual Behavior; Batchelder AW, Fitch C et. al.

Oct 23rd, 2021 - Sexual minority men disproportionately experience childhood sexual abuse (CSA) compared to heterosexual men, resulting in greater risk of psychiatric and substance use diagnoses, sexual risk taking, and HIV acquisition later in life. However, little is known about psychiatric and substance use disparities between gay and bisexual men who have experienced CSA. We recruited a purposive convenienc...

Thymoma-associated autoimmune enteropathy with colonic stricture: a diagnostic and hist...
https://doi.org/10.1007/s12328-021-01531-2 10.1038/cmi.2010.74 10.3109/08916930903555935 10.1080/08880010050211420 10.1007/s00428-017-2243-7 10.1016/j.cgh.2007.05.013 10.1056/NEJMcpc1406663 10.1093/ajcp/112.6.810 10.1007/s10620-005-2666-x 10.1007/s00428-018-2304-6 10.1007/s11894-012-0276-2 10.14309/crj.0000000000000520 10.1111/j.1572-0241.2004.40039.x 10.1136/gut.50.2.206
Clinical Journal of Gastroenterology; Pieplenbosch B, de Leijer JH et. al.

Oct 23rd, 2021 - Thymoma-associated autoimmune enteropathy is a rare paraneoplastic syndrome that is characterized by severe chronic diarrhea, malabsorption, and specific histological findings. Because of its rarity, it is difficult to diagnose. We describe an adult patient with protracted diarrhea and weight loss that developed recurrent sepsis and progressive colonic stenosis due to thymoma-associated autoimm...

The effect of immunosuppressive therapy in patients with fibrinoid necrosis lesions in ...
https://doi.org/10.1007/s40620-021-01176-x 10.1056/NEJMra1206793 10.2215/CJN.07420716 10.1093/ndt/gfy338 10.1053/j.ajkd.2019.04.031 10.1016/j.autrev.2015.02.003 10.1159/000445759 10.1053/j.ajkd.2012.06.011 10.1016/j.humpath.2018.01.026 10.1038/ki.2009.243 10.2215/CJN.11521210 10.1016/j.kint.2017.02.003 10.1046/j.1523-1755.2001.059002682.x 10.1111/j.1440-1827.1993.tb02558.x 10.2169/internalmedicine.40.862 10.1159/000065281 10.1590/s0100-879x2004000900012 10.1007/s40620-014-0165-x 10.1053/j.ajkd.2016.11.027 10.1053/ajkd.2002.31399 10.1093/ndt/gfg081 10.2215/CJN.02500317 10.1038/ki.1991.82 10.1038/ki.1990.148
Journal of Nephrology; Guo Y, Shi S et. al.

Oct 23rd, 2021 - Fibrinoid necrosis is considered one of the active pathological lesions in IgA nephropathy. Whether patients with IgA nephropathy with fibrinoid necrosis lesions benefit from immunosuppressive therapy in terms of long-term outcomes remains uncertain. This study aimed to evaluate the response to immunosuppressive therapy in patients with fibrinoid necrosis lesions in a large cohort of patients w...

Altered increase in STAT1 expression and phosphorylation in severe COVID-19.
https://doi.org/10.1002/eji.202149575
European Journal of Immunology; Rincon-Arevalo H, Aue A et. al.

Oct 23rd, 2021 - The interferon pathway, a key antiviral defense mechanism, is being considered as a therapeutic target in COVID-19. Both, substitution of interferon and JAK/STAT inhibition to limit cytokine storms have been proposed. However, little is known about possible abnormalities in STAT signaling in immune cells during SARS-CoV-2 infection. We investigated downstream targets of interferon signaling, in...

The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their...
https://doi.org/10.1113/JP281707
The Journal of Physiology; Wilson AD, Hu J et. al.

Oct 23rd, 2021 - RyR2 mutations can cause type-1 catecholaminergic polymorphic ventricular tachycardia (CPVT1), a lethal, autosomal-dominant arrhythmic disease. However, the changes in RyR2 ion-channel function that result from the many different patient mutations are rarely investigated in detail and often only recombinant RyR2, homozygous for the mutation, are studied. As CPVT1 is a heterozygous disease and t...