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Duration of Infectious Virus Shedding by SARS-CoV-2 Omicron Variant–Infected Vaccines
https://wwwnc.cdc.gov/eid/article/28/5/22-0197_article
Emerging Infectious Diseases; Takahash K, Ishikane M et. al.

Mar 15th, 2022 - To determine virus shedding duration, we examined clinical samples collected from the upper respiratory tracts of persons infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in Japan during November 29–December 18, 2021. Vaccinees with mild or asymptomatic infection shed infectious virus 6–9 days after onset or diagnosis, even after symptom resolution.

Vaccine Researcher Who Developed Tinnitus After COVID Shot Calls for Further Study
https://www.medpagetoday.com/special-reports/exclusives/97592
MedPage Today; Henderson J.

Mar 9th, 2022 - Gregory Poland, MD, director of the Mayo Clinic's Vaccine Research Group in Rochester, Minnesota, remains a steadfast vaccination advocate -- even though he developed tinnitus soon after receiving his second dose of COVID vaccine.

2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Kawasaki Disease
https://www.rheumatology.org/Portals/0/Files/Guideline-Management-Kawasaki-Disease.pdf
American College of Rheumatology; Gorelik M, .

Mar 8th, 2022 - Kawasaki disease (KD) is a medium vessel vasculitis as presented in the Chapel Hill Consensus Conference nomenclature system (1). It is 1 of 2 primary common vasculitis syndromes that predominantly affect children (the other being IgA vasculitis [Henoch-Schönlein]). KD is seen with relative frequency in young children, at an incidence rate of 25–50 cases per 100,000 persons per year in the U...

SARS-CoV-2 is associated with changes in brain structure in UK Biobank
https://www.nature.com/articles/s41586-022-04569-5
Nature Douaud G, .

Mar 7th, 2022 - There is strong evidence for brain-related abnormalities in COVID-191–13. It remains unknown however whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing to brain pathology. Here, we investigated brain changes in 785 UK Biobank participants (aged 51–81) imaged twice, including 401 cases who tested positive for i...

Molnupiravir’s authorisation was premature
https://www.bmj.com/content/376/bmj.o443
BMJ Brophy JM.

Mar 3rd, 2022 - On 1 October 2021 Merck issued a press release1 reporting an interim analysis of Move-Out, a phase 3 randomised placebo controlled trial in unvaccinated adults with confirmed SARS-Co-V infection and mild-to-moderate symptoms outside hospital. The press release stated that molnupiravir, a nucleoside analogue that inhibits viral replication by mutagenesis, reduced risk of hospital admission or de...

An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques
https://www.biorxiv.org/content/10.1101/2022.02.25.481974v1
BioRxiv Madden PJ, .

Feb 28th, 2022 - Because of the recognized systemic nature of SARS-CoV-2 infection, a non-invasive and unbiased method is needed to clarify its spatiotemporal dynamics in vivo after transmission. We recently developed a probe based on the anti-SARS-CoV-2 spike antibody CR3022 to study SARS-CoV-2 pathogenesis in vivo. Herein, we describe its use in immunoPET to investigate SARS-CoV-2 infection of rhesus macaques.

SARS-CoV-2 emergence very likely resulted from at least two zoonotic events
https://zenodo.org/record/6291628
Zenodo Pekar JE, .

Feb 26th, 2022 - Understanding the circumstances that lead to pandemics is critical to their prevention. Here, we analyze the pattern and origin of genomic diversity of SARS-CoV-2 early in the COVID-19 pandemic. We show that the SARS-CoV-2 genomic diversity prior to February 2020 comprised only two distinct viral lineages—denoted A and B—with no transitional haplotypes. Novel phylodynamic rooting methods, coupl...

Moxifloxacin - moxifloxacin solution/ drops-Lupin Pharmaceuticals, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ae77e219-8af9-4aa4-96d3-05c9726a1d3c

Jun 6th, 2022 - Moxifloxacin ophthalmic solution, 0.5% is a topical fluoroquinolone anti- infective indicated for the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: Corynebacterium species*, Micrococcus luteus*, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus warneri*, Streptococcus pneumonia...

Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line
https://www.mdpi.com/1467-3045/44/3/73/htm
Current Issues in Molecular Biology; Aldén M, .

Feb 25th, 2022 - Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro.

Evolving Patterns of Metastasis in Renal Cell Carcinoma: Do We Need to Perform Routine Bone Imaging?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523177/
Journal of Kidney Cancer and VHL; Lin J

Oct 13th, 2021 - Advance diagnostic and treatment modalities have improved outcomes for renal cell carcinoma (RCC) patients, but the prognosis for those with metastatic disease (mRCC) remains poor. As given metastatic distribution is critical in guiding treatment decisions for mRCC patients, we evaluated evolving metastatic patterns to assess if our current practice standards effectively address patient needs.

Germline Variants Identified in Patients with Early-onset Renal Cell Carcinoma Referred for Germline Genetic Testing
https://pubmed.ncbi.nlm.nih.gov/34654685/
European Urology Oncology; Truong H

Oct 12th, 2021 - Despite guidelines recommending genetic counseling for patients with early-onset renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations and clinical associations in patients with early-onset RCC are lacking.

Surveillance of SARS-CoV-2 in the environment and animal samples of the Huanan Seafood Market
https://www.researchsquare.com/article/rs-1370392/v1
Research Square; Gao G, .

Feb 22nd, 2022 - Emerging in December 2019, coronavirus disease 2019 (COVID-19) eventually became a pandemic and has posed a tremendous threat to global public health. However, the origins of SARS-CoV-2, the causative agent of COVID-19, remain to be determined. It has reported that a certain number of the early case clusters had a contact history with Huanan Seafood Market.

Procentra - dextroamphetamine sulfate solution-Independence Pharmaceuticals, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1548cce2-fb6b-4f17-8a3b-868933f6c9d6

Jun 1st, 2022 - ProCentra ® (dextroamphetamine sulfate) Oral Solution is indicated in: Narcolepsy Attention Deficit Disorder with Hyperactivity: As an integral part of a total treatment program that typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in pediatric patients (ages 3 years to 16 years) with a behavioral syndrome characterized by the following gr...

Quetiapine fumarate - quetiapine fumarate tablet, extended release-Lupin Pharmaceuticals, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7803a290-91c0-4e7f-90b5-d2ff33a46cee

Jun 1st, 2022 - Quetiapine extended-release tablet is an atypical antipsychotic indicated for the treatment of: Schizophrenia (1.1) Bipolar I disorder, manic or mixed episodes (1.2) Bipolar disorder, depressive episodes (1.2) Major depressive disorder, adjunctive therapy with antidepressants (1.3) Quetiapine extended-release tablet is indicated for the treatment of schizophrenia. The efficacy of quetiapine ext...

Covid-19: Antibodies after AstraZeneca and Pfizer vaccines decrease with age and are higher in women, data show
https://www.bmj.com/content/376/bmj.o428
BMJ Iacobucci G.

Feb 18th, 2022 - SARS-CoV-2 antibody levels after receiving the AstraZeneca or Pfizer-BioNTech vaccine decrease with age and are higher in females and people with prior infection, show data from the Real-time Assessment of Community Transmission (React-2) study.1

Imatinib mesylate - imatinib mesylate tablet, film coated-Apotex Corp
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0291eca5-7a1d-4a79-30be-252224d96509

May 30th, 2022 - Imatinib mesylate is a kinase inhibitor indicated for the treatment of: • Newly diagnosed adult and pediatric patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase (1.1) • Patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in blast crisis (BC), accelerated phase (AP), or in chronic phase (CP) after failure of interferon...

Antihistamines for Postacute Sequelae of SARS-CoV-2 Infection
https://www.sciencedirect.com/science/article/pii/S155541552100547X
The Journal for Nurse Practitioners; Pinto MD, .

Feb 7th, 2022 - Postacute sequelae of SARS-CoV2 (PASC) infection is an emerging global health crisis, variably affecting millions worldwide. PASC has no established treatment. We describe 2 cases of PASC in response to opportune administration of over-the-counter antihistamines, with significant improvement in symptoms and ability to perform activities of daily living. Future studies are warranted to understan...

Interplay between PCOS and Microbiome: The road less travelled.
https://doi.org/10.1111/aji.13580
American Journal of Reproductive Immunology (New York, N.... Batra M, Bhatnager R et. al.

May 23rd, 2022 - : Polycystic ovarian syndrome (PCOS) is a complicated neuro-endocrinal, reproductive, and metabolic condition. It encompasses patterns such as hyperandrogenism, recurrent cysts triggered by steroidogenic functional aberrations in the ovaries, overweight, chronic inflammation, and more. The underlying cause of this heterogeneous illness is obscure, although it is suspected to be driven by a blen...

Long-term ligature-induced periodontitis exacerbates development of bisphosphonate-rela...
https://doi.org/10.1002/jbmr.4614
Journal of Bone and Mineral Research : the Official Journ... Williams DW, Ho K et. al.

May 23rd, 2022 - Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a detrimental intraoral lesion that occurs in patients with long-term or high-dose use of anti-resorptive agents such as bisphosphonates. Tooth extraction is a known risk factor for BRONJ, and such intervention is often performed to eliminate existing pathological inflammatory conditions. Previously, we determined that ligature-induced ...

Microvascular changes in the recurrent cystoid macular edema secondary to posterior non...
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International Ophthalmology; Albano V, Guerriero S et. al.

May 23rd, 2022 - Posterior uveitis represents the second most frequent type of uveitis (15-30% of all uveitis). Noninfectious posterior uveitis complicated with secondary cystoid macular edema (CME) affects the visual prognosis negatively. The objective of the current study is to detect possible microvascular changes causing relapsing uveitis-related CME using optical coherence tomography angiography (OCTA). Th...