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About 1,680,508 results

Unravelling protein turnover in duchenne muscular dystrophy: One protein at a time.
https://doi.org/10.1113/JP282386
The Journal of Physiology; McKendry J, Phillips SM

Oct 23rd, 2021 - Unravelling protein turnover in duchenne muscular dystrophy: One protein at a time.|2021|McKendry J,Phillips SM,|

OPEN SURGERY FOR IN UTERO REPAIR OF SPINA BIFIDA: MICRONEUROSURGERY VS STANDARD TECHNIQ...
https://doi.org/10.1002/pd.6063
Prenatal Diagnosis; Molina-Giraldo S, Salcedo RZ et. al.

Oct 23rd, 2021 - Prenatal myelomeningocele (MMC) repair has been shown to improve neurological outcomes. It has been suggested that decreases in the hysterotomy diameter during surgery can improve perinatal outcomes without altering neurologic outcomes. The objective of this study is to describe and compare the main maternal and fetal outcomes of fetuses undergoing open surgery for MMC repair, through the diffe...

THE EVALUATION POTENTIAL GLOBAL IMPACT OF THE N501Y MUTATION IN SARS-COV-2 POSITIVE PAT...
https://doi.org/10.1002/jmv.27413
Journal of Medical Virology; Komurcu SZM, Artik Y et. al.

Oct 23rd, 2021 - Rapid and reliable detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations are significant to control the contagion and spread rate of the virus. We aimed to evaluate the N501Y mutation rate in randomly chosen positive patients with polymerase chain reaction (PCR). The evaluation and analysis of the data in terms of public health will contribute to the literature on ...

Is the course of COVID-19 associated with tuberculin skin test diameter? A retrospectiv...
https://doi.org/10.1002/jmv.27414
Journal of Medical Virology; Gulen TA, Bayraktar M et. al.

Oct 23rd, 2021 - The pathogenesis of COVID-19 is still not fully understood. Since SARS-COV-2 has a similar pathogenetic pathway to Mycobacterium tuberculosis, it has been reported that there may be a relationship between BCG vaccination rate and COVID-19 severity. This study investigated the relationship between tuberculin skin test (TST) induration diameter and the clinical course of COVID-19. Of 1963 adult p...

LncRNA PTPRG-AS1 facilitates glycolysis and stemness properties of esophageal squamous ...
https://doi.org/10.1111/jgh.15719
Journal of Gastroenterology and Hepatology; Wu K, Wang Z et. al.

Oct 23rd, 2021 - Esophageal squamous cell carcinoma (ESCC) is the most significant subtype of esophageal cancer featured with high occurrence. Long noncoding RNAs (lncRNAs) have been proved to modulate the biological properties of cancer cells, including cell proliferation, invasion, migration and apoptosis. LncRNA protein tyrosine phosphatase receptor type G-antisense RNA 1 (PTPRG-AS1) has been reported to pla...

Performance evaluation of Elecsys SARS-CoV-2 Antigen immunoassay for diagnostic of COVI...
https://doi.org/10.1002/jmv.27412
Journal of Medical Virology; Montalvo Villalba MC, Sosa Glaria E et. al.

Oct 23rd, 2021 - One of challenge for control and prevention of SARS-CoV-2 infection is the early diagnostic at the point of care. Several tests based on qualitative antigen detection have been developed; one of these is Elecsys SARS-CoV-2 Antigen immunoassay (Roche Diagnostics). In total 523 nasopharyngeal swabs were randomly selected with the aims to evaluate sensitivity, specificity, cross-reactivity, positi...

Applying Deep Learning to Quantify Empty Lacunae in Histologic Sections of Osteonecrosi...
https://doi.org/10.1002/jor.25201
Journal of Orthopaedic Research : Official Publication Of... Lui E, Maruyama M et. al.

Oct 23rd, 2021 - Osteonecrosis of the femoral head (ONFH) is a disease in which inadequate blood supply to the subchondral bone causes death of cells in the bone marrow. Decalcified histology and assessment of the percentage of empty lacunae are used to quantify the severity of ONFH. However, the current clinical practice of manually counting cells is a tedious and inefficient process. We utilized the power of ...

Update of recent findings in genetic hair disorders.
https://doi.org/10.1111/1346-8138.16204
The Journal of Dermatology; Hayashi R, Shimomura Y

Oct 23rd, 2021 - Genetic hair disorders, although unusual, are not very rare, and dermatologists often have opportunities to see patients. Significant advances in molecular genetics have led to identifying many causative genes for genetic hair disorders, including the recently identified causative genes, such as LSS and C3ORF52. Many patients have been detected with autosomal recessive woolly hair/hypotrichosis...

Immunoglobulin A nephropathy in pediatrics: an up-to-date.
https://doi.org/10.1111/nep.13987
Nephrology (Carlton, Vic.); Paranhos RM, de Souza Figueiredo GA et. al.

Oct 23rd, 2021 - Immunoglobulin A nephropathy is the main cause of glomerulonephritis globally and an important etiology of end-stage renal disease in children. It has been considered an autoimmune disease that can lead to the production of autoantibodies against abnormal IgA1 and formation of immune complexes. These autoantibodies and immune complexes deposit in the glomeruli, resulting in renal injury. At the...

The lectin pathway does not contribute to glomerular injury in the nephrotoxic nephriti...
https://doi.org/10.1111/nep.13988
Nephrology (Carlton, Vic.); Freeley SJ, Tham E et. al.

Oct 23rd, 2021 - Rapidly progressive crescentic glomerulonephritis occurs in a number systemic and primary glomerular diseases, including anti-glomerular basement membrane disease, anti-neutrophil cytoplasmic antibody vasculitis, and lupus nephritis. Our understanding of pathogenic mechanisms comes from animal models of disease such as the nephrotoxic nephritis model. The lectin pathway of complement activation...

Pediatric Discoid Lupus Erythematosus: Short report.
https://doi.org/10.1111/dth.15170
Dermatologic Therapy; Hawat T, Ballouz S et. al.

Oct 23rd, 2021 - Pediatric discoid lupus erythematosus is a rare inflammatory skin disorder. This paper aims to review all the available clinical and therapeutic data on reported cases of pediatric discoid lupus erythematosus. A systematic review of the literature was conducted using Pubmed and Embase with no limitation on publication date, sex or nationality. 32 articles were included with 201 cases, a mean ag...

Cachexia index as a potential biomarker for cancer cachexia and a prognostic indicator ...
https://doi.org/10.1002/jcsm.12837
Journal of Cachexia, Sarcopenia and Muscle; Go SI, Park MJ et. al.

Oct 23rd, 2021 - Cancer cachexia is known to adversely affect the clinical course in patients with malignant lymphoma. The cachexia index (CXI) is a potential biomarker of cancer cachexia, and its implications for the prognosis and treatment outcome of lung cancer and aggressive lymphoma has been assessed in previous studies. A total of 267 patients diagnosed with diffuse large B-cell lymphoma who were treated ...

Exercise duration modulates upper and lower respiratory fluid cellularity, antiviral ac...
https://doi.org/10.14814/phy2.15075
Physiological Reports; Elkhatib SK, Alley J et. al.

Oct 23rd, 2021 - Exercise has substantial health benefits, but the effects of exercise on immune status and susceptibility to respiratory infections are less clear. Furthermore, there is limited research examining the effects of prolonged exercise on local respiratory immunity and antiviral activity. To assess the upper respiratory tract in response to exercise, we collected nasal lavage fluid (NALF) from human...

A modern approach to dyslipidemia.
https://doi.org/10.1210/endrev/bnab037
Endocrine Reviews; Berberich AJ, Hegele RA

Oct 23rd, 2021 - Lipid disorders involving derangements in serum cholesterol, triglycerides or both are commonly encountered in clinical practice and often have implications for cardiovascular risk and overall health. Recent advances in knowledge, recommendations and treatment options have necessitated an updated approach to these disorders. Older classification schemes have outlived their usefulness yielding t...

Dominant Clade-featured SARS-CoV-2 Co-occurring Mutations Reveals Plausible Epistasis: ...
https://doi.org/10.1002/jmv.27416
Journal of Medical Virology; Rubayet Ul Alam ASM, Islam OK et. al.

Oct 23rd, 2021 - SARS-CoV-2 is evolved into eight fundamental clades where four (G, GH, GR, and GV) are globally prevalent in 2020. To explain plausible epistatic effects of the signature co-occurring mutations of these circulating clades on viral replication and transmission fitness, we proposed a hypothetical model using in silico approach. Molecular docking and dynamics analyses showed the higher infectiousn...

circCORO1C promotes the proliferation and metastasis of hepatocellular carcinoma by enh...
https://doi.org/10.1002/jcla.24003
Journal of Clinical Laboratory Analysis; Wu F, Sun G et. al.

Oct 23rd, 2021 - Circular RNA (circRNA) affects the occurrence and development of human cancers, but the specific mechanism of hepatocellular carcinoma (HCC) has not yet been fully understood. CircRNAs were determined by human circRNA array analysis and quantitative reverse transcription polymerase chain reaction (qRT-PCR). Cell viability, migration, invasion, and other indicators were used for cell function an...

High expression of DHX9 promotes the growth and metastasis of hepatocellular carcinoma.
https://doi.org/10.1002/jcla.24052
Journal of Clinical Laboratory Analysis; Shi F, Cao S et. al.

Oct 23rd, 2021 - DHX9, an NTP-dependent RNA helicase, is closely associated with the proliferation and metastasis of some tumor cells and the prognosis of patients, but its role in hepatocellular carcinoma (HCC) is not well-known. This study was performed to explore the expression and role of DHX9 in HCC. The expression of DHX9 in HCC tissues and cell lines was detected by TCGA database, qPCR, western blotting,...

Double immune reconstitution therapy: cladribine after alemtuzumab in treatment of mult...
https://doi.org/10.1111/ene.15153
European Journal of Neurology; Adamec I, Jovanović I et. al.

Oct 23rd, 2021 - Alemtuzumab, a monoclonal anti-CD52 antibody, and cladribine, a purine nucleoside analogue, are used for treatment of highly active relapsing remitting multiple sclerosis (MS). Both are administered as two short yearly courses but possess the ability to induce long-term remission labeling them as immune reconstitution therapies. Although disease activity after alemtuzumab administration is rare...

Development and Validation of an Online Calculator to Predict Early Recurrence and Long...
https://doi.org/10.1002/jhbp.1058
Journal of Hepato-biliary-pancreatic Sciences; Xu S, Zhang XP et. al.

Oct 23rd, 2021 - Distal Cholangiocarcinoma (DCC) is a malignancy associated with a short survival time. In this study, we aimed to create an online nomogram calculator to predict early recurrence and long-term survival in patients with DCC after pancreaticoduodenectomy. A total of 486 patients with DCC were included. An online nomogram calculator was developed and validated in training, internal validation and ...

Is Technical Expertise Necessary to Assess Technical Expertise? Let's Ask the Kids.
https://doi.org/10.1089/lap.2021.0321
Journal of Laparoendoscopic & Advanced Surgical Technique... Nair D, Wells JM et. al.

Oct 23rd, 2021 - Background: Simulation has an increasing role in surgical training; however, using validated tools such as the Objective Structured Assessment of Technical Skills (OSATS) is time-consuming, which may be a potential barrier to simulation-based training. This study tests the hypothesis that assessors with technical expertise are necessary to objectively score a technical task. Methods: Three task...