Dermatologic Therapy; Hawat T, Ballouz S et. al.
Oct 23rd, 2021 - Pediatric discoid lupus erythematosus is a rare inflammatory skin disorder. This paper aims to review all the available clinical and therapeutic data on reported cases of pediatric discoid lupus erythematosus. A systematic review of the literature was conducted using Pubmed and Embase with no limitation on publication date, sex or nationality. 32 articles were included with 201 cases, a mean ag...
Proteomics. Clinical Applications; Sosa-Acosta P, Melani RD et. al.
Oct 23rd, 2021 - During pregnancy, the vertical transmission of the Zika virus (ZIKV) can cause some disorders in the fetus, called Congenital Zika Syndrome (CZS). Several efforts have been made to understand the molecular mechanism of the CZS. However, the study of CZS pathogenesis through infected human samples is scarce. Therefore, the main goal of this study is to identify and understand the biological proc...
BJOG : an International Journal of Obstetrics and Gynaeco... Sobel R, Nyirjesy P et. al.
Oct 23rd, 2021 - To evaluate the efficacy and safety of ibrexafungerp vs placebo for acute vulvovaginal candidiasis (VVC) treatment. Global phase 3, randomised, placebo-controlled superiority study. Study sites in the United States (n=19) and Bulgaria (n=18). Female patients aged ≥12 years with acute VVC and a vulvovaginal signs and symptoms (VSS) score ≥4 at baseline. Patients were randomly assigned 2:1 to ibr...
Journal of Cachexia, Sarcopenia and Muscle; Go SI, Park MJ et. al.
Oct 23rd, 2021 - Cancer cachexia is known to adversely affect the clinical course in patients with malignant lymphoma. The cachexia index (CXI) is a potential biomarker of cancer cachexia, and its implications for the prognosis and treatment outcome of lung cancer and aggressive lymphoma has been assessed in previous studies. A total of 267 patients diagnosed with diffuse large B-cell lymphoma who were treated ...
Physiological Reports; Elkhatib SK, Alley J et. al.
Oct 23rd, 2021 - Exercise has substantial health benefits, but the effects of exercise on immune status and susceptibility to respiratory infections are less clear. Furthermore, there is limited research examining the effects of prolonged exercise on local respiratory immunity and antiviral activity. To assess the upper respiratory tract in response to exercise, we collected nasal lavage fluid (NALF) from human...
Multiple Sclerosis (Houndmills, Basingstoke, England); Delgado-García G, Corona T
Oct 23rd, 2021 - Air pollution is a risk factor for multiple sclerosis - No.|2021|Delgado-García G,Corona T,|
Multiple Sclerosis (Houndmills, Basingstoke, England); Bergamaschi R, Montomoli C
Oct 23rd, 2021 - Air pollution is a risk factor for multiple sclerosis - Yes.|2021|Bergamaschi R,Montomoli C,|
Physiological Reports; Schena G, Carmosino M et. al.
Oct 23rd, 2021 - Autosomal dominant polycystic kidney disease (ADPKD) disrupts renal parenchyma through progressive expansion of fluid-filled cysts. The only approved pharmacotherapy for ADKPD involves the blockade of the vasopressin type 2 receptor (V2R). V2R is a GPCR expressed by a subset of renal tubular cells and whose activation stimulates cyclic AMP (cAMP) accumulation, which is a major driver of cyst gr...
COPD Mobeen F, Edgar RG et. al.
Oct 23rd, 2021 - Alpha-1 Antitrypsin deficiency (AATD) is a genetic condition that can lead to Chronic Obstructive Pulmonary Disease. The burden of psychological disease, its impact and contributing factors in patients with AATD are largely unknown. This study determined the prevalence of depression and anxiety in AATD and its clinical impact. All subjects with PiZZ/PiZnull (n = 635) and PiSZ (n = 111) genotype...
Journal of Cosmetic and Laser Therapy : Official Publicat... Choi YJ, Yim S et. al.
Oct 23rd, 2021 - Becker's nevus (BN) clinically presents as brown patches with hypertrichosis. The risk of pigmentary changes still remains a concern when using lasers to treat Asian patients with BN. We aimed to evaluate the outcomes on reduction of hairs and pigment of BN using the long-pulsed 1064-nm Nd:YAG (LPNY) and/or 755-nm alexandrite (LP-Alex), before treating pigment in earnest. A total of 13 subjects...
Leukemia & Lymphoma; Ramalingam TR, Mohanraj S et. al.
Oct 23rd, 2021 - Immunophenotyping plays a major role and is essential for establishing the diagnosis of chronic lymphocytic leukemia (CLL). Though CLL has a characteristic phenotype, diagnosis may be challenging due to immunophenotypic overlap with other B cell non-Hodgkin's lymphomas (B-NHL). Markers like CD200, CD43, CD20 and CD45 were found valuable in CLL and we investigated their diagnostic efficiency and...
Journal of Pediatric Gastroenterology and Nutrition; Story E, Bijelic V et. al.
Oct 23rd, 2021 - To evaluate for increased rectal bleeding following enoxaparin thromboprophylaxis in children hospitalized for ulcerative colitis (UC). Retrospective cohort study (2007--2016) of 218 inpatients with active UC. Patients receiving enoxaparin were compared with a nonenoxaparin-treated patient group. Severity of UC was determined using the Pediatric Ulcerative Colitis Activity Index (PUCAI). Hemogl...
Endocrine Reviews; Berberich AJ, Hegele RA
Oct 23rd, 2021 - Lipid disorders involving derangements in serum cholesterol, triglycerides or both are commonly encountered in clinical practice and often have implications for cardiovascular risk and overall health. Recent advances in knowledge, recommendations and treatment options have necessitated an updated approach to these disorders. Older classification schemes have outlived their usefulness yielding t...
Molecular Medicine Reports; Wang Y, Fan Y et. al.
Oct 23rd, 2021 - Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the western blotting data shown in Fig. 2B and flow cytometric data shown in Fig. 3B bore unexpected similarities to data appearing in different form in other articles by different authors. Furthermore, there were additional concerns regarding the possibly anomalous appearance o...
Oncology Reports; Cui CL, Li YN et. al.
Oct 23rd, 2021 - The authors wish to retract their research article entitled 'lncRNA XIST promotes the progression of laryngeal squamous cell carcinoma by sponging miR‑144 to regulate IRS1 expression', published in Oncology Reports 43: 525‑535, 2020. They have found that, having repeated several of the experiments, XIST expression does not appear to affect LSCC cell apoptosis. In addition, some of their origina...
Journal of Medical Virology; Rubayet Ul Alam ASM, Islam OK et. al.
Oct 23rd, 2021 - SARS-CoV-2 is evolved into eight fundamental clades where four (G, GH, GR, and GV) are globally prevalent in 2020. To explain plausible epistatic effects of the signature co-occurring mutations of these circulating clades on viral replication and transmission fitness, we proposed a hypothetical model using in silico approach. Molecular docking and dynamics analyses showed the higher infectiousn...
Journal of Clinical Laboratory Analysis; Wu F, Sun G et. al.
Oct 23rd, 2021 - Circular RNA (circRNA) affects the occurrence and development of human cancers, but the specific mechanism of hepatocellular carcinoma (HCC) has not yet been fully understood. CircRNAs were determined by human circRNA array analysis and quantitative reverse transcription polymerase chain reaction (qRT-PCR). Cell viability, migration, invasion, and other indicators were used for cell function an...
Journal of Clinical Laboratory Analysis; Shi F, Cao S et. al.
Oct 23rd, 2021 - DHX9, an NTP-dependent RNA helicase, is closely associated with the proliferation and metastasis of some tumor cells and the prognosis of patients, but its role in hepatocellular carcinoma (HCC) is not well-known. This study was performed to explore the expression and role of DHX9 in HCC. The expression of DHX9 in HCC tissues and cell lines was detected by TCGA database, qPCR, western blotting,...
European Journal of Neurology; Adamec I, Jovanović I et. al.
Oct 23rd, 2021 - Alemtuzumab, a monoclonal anti-CD52 antibody, and cladribine, a purine nucleoside analogue, are used for treatment of highly active relapsing remitting multiple sclerosis (MS). Both are administered as two short yearly courses but possess the ability to induce long-term remission labeling them as immune reconstitution therapies. Although disease activity after alemtuzumab administration is rare...
PM & R : the Journal of Injury, Function, and Rehabilitat... Matsuda PN, Hoffman JM
Oct 23rd, 2021 - Patient Perspectives on Falls in Persons with Multiple Sclerosis.|2021|Matsuda PN,Hoffman JM,|