About 2,217,398 results

Detection of Monkeypox Virus in Anorectal Swabs From Asymptomatic Men Who Have Sex With Men in a Sexually Transmitted Infection Screening Program in Paris, France
Annals of Internal Medicine; Ferré VM, .

Aug 16th, 2022 - Background: A monkeypox virus (MPXV) outbreak emerged in May 2022, affecting mostly men who have sex with men (MSM). Although most infections were characterized by cutaneous lesions, a recent report described 3 asymptomatic men with no cutaneous lesions but with positive results on anorectal MPXV polymerase chain reaction (PCR) testing (1).

Blood abnormalities found in people with Long Covid
Science Couzin-Frankel J.

Aug 16th, 2022 - An ambitious study of people with Long Covid, the mysterious, disabling symptoms that can trail a SARS-CoV-2 infection, has turned up a host of abnormalities in their blood. The clues add to a body of evidence hinting at drivers of the condition and potential treatments worth testing. They also suggest that, as many scientists and patients have suspected, Long Covid shares certain features with...

Risk of SARS-CoV-2 Acquisition in Health Care Workers According to Cumulative Patient Exposure and Preferred Mask Type
JAMA Network Open; Dörr T, Haller S et. al.

Aug 15th, 2022 - Health care workers (HCWs) are at increased risk for acquiring SARS-CoV-2 infection,1 raising the issue of adequate protective measures. Although scientific evidence regarding the benefit of respirator vs surgical masks is sparse,2,3 a previous study has suggested that respirator masks (ie, FFP2) may offer additional protection to HCW with frequent COVID-19-patient exposure.4 In this follow-up ...

Idiopathic Pulmonary Capillaritis Within the Spectrum of Pediatric Diffuse Alveolar Hemorrhage
Angela Chun, Tiphanie vogel, Andrea Ramirez et. al.

Nov 14th, 2022 - Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a life-threatening syndrome with bleeding from the pulmonary microvasculature. It is classified as pulmonary capillaritis if histology shows neutrophilic invasion with fibrinoid necrosis of capillary walls. This can occur secondary to systemic autoimmune disease or in isolation as idiopathic pulmonary capillaritis (IPC). There is a paucit...

Characterizing Phenotypic Changes by SARS-CoV-2 Variant in Multisystem Inflammatory Syndrome in Children (MIS-C): A Single Institution Case Series
Sandy D. Hong1 and Emma Leisinger, University of Iowa Stead Family Children's Hospital, Iowa City et. al.

Nov 14th, 2022 - Background/Purpose: Multisystem inflammatory syndrome in children (MIS-C) is a severe hyper-inflammatory condition associated with a recent SARS-CoV-2 infection. Case reports began in April of 2020 from Italy and the United Kingdom documenting cases of children with shock-like illness and features of Kawasaki Disease (KD). Epidemiologic data demonstrates a latent rise and peak of MIS-C cases ap...

Histopathological Patterns of Muscle Involvement and Clinical Correlations in a Retrospective Cohort of Scleroderma Patients
Noemie Le Gouellec, Louai Zaidan, Eric Hachulla et. al.

Nov 14th, 2022 - Background/Purpose: Muscle involvement in systemic sclerosis (SSc) has been shown to be heterogeneous. Histopathological pattern seems to be associated with prognosis, but studies evaluating the correlations between muscle involvement subtypes, clinical presentation and outcomes are scarce. The aim of this study was to evaluate the prognostic value of histopathological muscular type in SSc. Met...

Determining the Long-term Safety and Efficacy of JAK Inhibitors in the Treatment of Dermatomyositis: A Retrospective Cohort Study
Shivani Rangaswamy, Lisa Christopher-Stine, Jemima Albayda et. al.

Nov 14th, 2022 - Background/Purpose: JAK inhibitors have been reported to be a promising treatment for dermatomyositis, an idiopathic inflammatory myopathy. However, the FDA recently added a black box label warning for all JAK inhibitors due to reports indicating increased risk of cardiovascular events, strokes, and cancer. Given these new safety concerns, this study leverages a large North American myositis re...

Idiopathic Inflammatory Myopathies in Alaska Native/American Indian People in Alaska
Vivek Mehta and Elizabeth Ferucci, Alaska Native Tribal Health Consortium, Anchorage et. al.

Nov 14th, 2022 - Background/Purpose: Racial disparities have been in noted in various autoimmune disorders. Indigenous North American populations have higher prevalence and severity of a number of autoimmune disorders, but few studies have examined the clinical characteristics of Idiopathic Inflammatory Myopathies (IIM) in Indigenous North American populations. We sought to describe the clinical characteristics...

The Potential Diagnostic Value of C-X-C Motif Chemokine 13 (CXCL13) in Seronegative Arthritis
Silvia Piantoni, Fabrizio Angeli, Francesca Regola et. al.

Nov 14th, 2022 - Background/Purpose: The finding of circulating biomarkers in the field of chronic arthritis is still an unmet need, especially for the subgroup of seronegative arthritis [e.g., negative for anti-citrullinated peptides autoantibodies (ACPA) and/or rheumatoid factors (RF)]. In fact, in this clinical subset, there is a lack of soluble molecules which could help for a diagnostic or prognostic purpo...

Idiopathic Pulmonary Fibrosis Molecular Profile Correlates with Stage of Rheumatoid Arthritis-Associated Interstitial Lung Disease
Daniel Kass, Mehdi Nouraie, Yingze Zhang et. al.

Nov 14th, 2022 - Background/Purpose: Previous studies have demonstrated clinical, epidemiologic, histopathologic, and genetic overlap between advanced rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and Idiopathic Pulmonary Fibrosis (IPF). Corresponding work from our group has shown that a number of serum protein biomarkers of IPF are shared with RA-ILD. We therefore assessed the expression o...

COVID-19 mRNA Vaccine Induced Antibody Titers and IFN-g Responses Are Decreased in Persons with Rheumatoid Arthritis and Older Age
Holly Dudley, megan O'Mara, Ann Auma et. al.

Nov 14th, 2022 - Background/Purpose: People with autoimmune diseases have worse outcomes if infected by SARS-CoV2. In particular, persons with rheumatoid arthritis (RA), have lower antibody responses to COVID-19 vaccine, are more commonly diagnosed with COVID-19 and have worse outcomes once infected. Some of these observations may in part be attributable to immune suppressive medications including steroids, Rit...

Systematic Screening of Multimorbidities Results in an Increased Intake of Comorbidity Preventive Medications and a Decreased Hospitalization Rate
Claire DAIEN, Vera Georgescu, Guillaume Decarriere et. al.

Nov 14th, 2022 - Background/Purpose: A systematic screening of multimorbidities is performed since 2014 at the Montpellier University Hospital in patients with chronic inflammatory rheumatic diseases (IRD). The objective of this work was to assess the impact of this screening on management of patients and hospitalization rate during a 3-year follow-up. Methods: Patients with IRD who benefit from the screening p...

Focused Clinical Correlation of Autoantibody Testing in Juvenile Systemic Sclerosis and Localized Scleroderma Using the Euroimmun™ Scleroderma Disease Profile
Jonathan Li, Emily Mirizio, Katherine Buhler et. al.

Nov 14th, 2022 - Background/Purpose: Commercially available autoantibody (AAb) panels are developed for adult rheumatological diseases; application to pediatric disease has not been established. As a pediatric scleroderma referral center and clinic, one of our main interests is to examine the properties of the Euroimmun™ Scleroderma Disease Profile in juvenile-onset scleroderma. These panels may be useful for p...

Effectiveness of the BNT162b2 mRNA COVID-19 Vaccine Among Adolescents with Juvenile-onset Inflammatory Rheumatic Diseases
amit ziv, Merav Heshin-Bekenstein, Ruby Haviv et. al.

Nov 14th, 2022 - Background/Purpose: Effectiveness of the BNT162b2 mRNA COVID-19 vaccine for adolescents with juvenile-onset inflammatory rheumatic diseases (IRD) is unknown. Several studies suggested attenuated immunogenicity in patients with IRD. This study evaluated the effectiveness of the BNT162b2 mRNA COVID-19 vaccine in preventing COVID-19 infection in adolescents with juvenile-onset IRD compared to cont...

Clinical Characteristics and Outcomes of Pediatric ANCA-Associated Vasculitis Patients: Single-Center Inception Cohort
Hyun Ho Lee, Lauren Blazek2 and Eveline Wu, The University of North Carolina Chapel Hill et. al.

Nov 14th, 2022 - Background/Purpose: ANCA associated vasculitis (AAV) is a chronic autoimmune disorder characterized by ANCA production and small vessel inflammation and necrosis. ANCA autoantigen targets include myeloperoxidase (MPO-ANCA) and proteinase 3 (PR3-ANCA). There is growing evidence that ANCA specificity may be more predictive of prognosis and outcome than clinical phenotype. Due to the scarcity of d...

Racial Disparities Influence Healthcare Utilization in Pediatric Rheumatology Clinic
William Soulsby1 and Emily von Scheven, University of California, San Francisco et. al.

Nov 14th, 2022 - Background/Purpose: Racial disparities are prevalent in chronic illness, including pediatric rheumatic diseases. Prior work has investigated the impact of race on disease activity and damage in rheumatic diseases, such as lupus, but has not studied its impact on healthcare utilization patterns. As part of an institutional effort at the University of California, San Francisco (UCSF) to understan...

Efficacy of the COVID-19 Vaccine in Pediatric Systemic Lupus Erythematosus Patients
Yi Shi, Catherine Park, Sangeeta Sule2 and Sun-Young Ahn et. al.

Nov 14th, 2022 - Background/Purpose: The COVID-19 virus has caused significant morbidity and mortality, despite introduction of the COVID vaccine. Immunocompromised patients have been shown to have reduced response to the COVID vaccine compared to healthy individuals. There is currently limited data on the responsiveness of pediatric systemic lupus erythematosus (SLE) patients to the COVID vaccine. Methods: To ...

Mice Do Not Develop CIA: Knocking out of Kv1.3 Renders CD4+TEMCells Resistant to Activation
Siba Raychaudhuri, Smriti Raychaudhuri2 and Heike Wulff, UC Davis et. al.

Nov 14th, 2022 - Background/Purpose: Engagement of the TCR triggers Ca++ influx through Ca++ channels. Ca++ influx is only possible with a counterbalancing K+ efflux through Kv1.3 and/or KCa3.1. Given its regulatory role in effector memory T cells, Kv1.3 is likely to play a critical role in the pathogenesis of T cell mediated autoimmune arthritis such as in rheumatoid arthritis (RA) and psoriatic arthritis (PsA...

Anti-S1 Antibody Levels Two Weeks After the Second Dose of an mRNA anti-SARS-CoV2 Vaccine Predict Maintenance of a Potent Neutralizing Activity over 24 Weeks in RA Patients
Kristin Schmiedeberg, Irene Abela, Nicolas Vuilleumier et. al.

Nov 14th, 2022 - Background/Purpose: Patients with inflammatory rheumatic diseases (IRD) on immunomodulatory therapies have a higher likelihood of an impaired vaccine-induced immune response following an mRNA anti-SARS-CoV-2 vaccine. Determination of anti-S1 levels may serve as a surrogate for protection and may guide when to schedule a subsequent vaccine dose but data regarding the optimal timepoint for assess...

Efficacy of JAK Inhibitors in Idiopathic Inflammatory Myopathies (other Than Dermatomyositis)
Ana Campar, Ana Sá, Bárbara Oliveira2 and António Marinho et. al.

Nov 14th, 2022 - Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a rare and heterogeneous group of systemic autoimmune disorders, comprising dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM), polymyositis (PM), inclusion body myositis (IBM) and overlap myositis in which antisynthetase syndrome (ASS) is included. Treatment remains empiric as no on-label drug has been approved so ...