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About 2,360,348 results

Vibrio vulnificus sepsis after shrimp shelling in a patient with preexisting primary bi...
https://doi.org/10.1186/s13256-023-03767-7
Journal of Medical Case Reports; Sakihara E, Noge I et. al.

Jan 29th, 2023 - Vibrio vulnificus is typically present in seawater, fish, and shellfish, and is known to cause severe sepsis, particularly in patients with liver diseases such as cirrhosis. V. vulnificus is one of the most dangerous waterborne pathogens, and infection mainly occurs in western Japan during the summer, with an increased fatality rate. Herein, we report the case of a patient with primary biliary ...

The prognostic value and immune correlation of IL18 expression and promoter methylation...
https://doi.org/10.1186/s13148-023-01426-8
Clinical Epigenetics; Wang X, Zhu W et. al.

Jan 29th, 2023 - Renal cell carcinoma (RCC) is not sensitive to immunotherapy and has poor prognosis. DNA methylation regulates gene expression, and its abnormal changes are related to many human diseases. Recently, DNA methylation has been found to participate in immune infiltration in various cancers. However, its pattern in RCC remains poorly understood. We found that IL18 was significantly over-expressed in...

Multi-country evaluation of the durability of pyrethroid plus piperonyl-butoxide insect...
https://doi.org/10.1186/s12936-023-04465-x
Malaria Journal; Mbuba E, Odufuwa OG et. al.

Jan 29th, 2023 - Mass distributions of long-lasting insecticidal nets (LLINs) have contributed to large reductions in the malaria burden. However, this success is in jeopardy due in part to the increasing pyrethroid-resistant mosquito population as well as low LLINs coverage in various areas because the lifespan of LLINs is often shorter than the interval between replenishment campaigns. New insecticide-treated...

Childhood-onset primary Sjögren's syndrome in a tertiary center in China: clinical feat...
https://doi.org/10.1186/s12969-022-00779-3
Pediatric Rheumatology Online Journal; Gong Y, Liu H et. al.

Jan 29th, 2023 - To characterize the clinical features and outcomes of childhood-onset primary Sjögren's syndrome (pSS). Patients less than 18 years old who were diagnosed with pSS by paediatric rheumatologists were included, and all patients were applied the 2002 American-European Consensus Group (ACEG) criteria, the 2016 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria ...

Exaggerated levels of some specific TLRs, cytokines and chemokines in Japanese encephal...
https://doi.org/10.1186/s12985-023-01966-8
Virology Journal; Shukla M, Garg A et. al.

Jan 29th, 2023 - Japanese encephalitis (JE) disease, a viral brain fever is caused by Japanese encephalitis virus (JEV). Despite the availability of effective vaccines against this deadly infection, JE is the leading cause of epidemic viral encephalitis in children in South-east Asia. There is no treatment available for the JE disease which might be due to incomplete understanding of the pathogenesis of JE viru...

Identification and validation of pyroptosis-related gene landscape in prognosis and imm...
https://doi.org/10.1186/s13048-022-01065-2
Journal of Ovarian Research; Gao L, Ying F et. al.

Jan 29th, 2023 - Emerging evidence has highlighted the biological significance of pyroptosis in tumor tumorigenesis and progression. Nonetheless, the potential roles of pyroptosis in tumor immune microenvironment and target therapy of ovarian cancer (OC) remain unknown. In this study, with a series of bioinformatic and machine learning approaches, we comprehensively evaluated genetic alterations and transcripto...

The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway i...
https://doi.org/10.1186/s12967-023-03895-0
Journal of Translational Medicine; Shen X, Zhi F et. al.

Jan 29th, 2023 - Arsenic trioxide (ATO) is the first-line therapeutic drug for acute promyelocytic leukemia. However, the cardiotoxicity of ATO limits its clinical application. This study aims to explore the long noncoding RNA (lncRNA) involved molecular mechanism in ATO-induced cardiotoxicity and to identify available prevention strategies. ATO was administered to mice or primary cultured mouse cardiomyocytes....

Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upr...
https://doi.org/10.1186/s13024-023-00597-5
Molecular Neurodegeneration; Kisler K, Sagare AP et. al.

Jan 29th, 2023 - PICALM is one of the most significant susceptibility factors for Alzheimer's disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium. PICALM endothelial levels are reduced in AD brains. PICALM controls several steps in Aβ transcytosis across the blood-brain barrier (BBB). Its loss from brain endothelium in mice diminishes Aβ clearance at the BBB, which worsens Aβ patho...

Integrated investigation of the clinical implications and targeted landscape for RNA me...
https://doi.org/10.1186/s40001-023-01016-7
European Journal of Medical Research; Zhang J, Gao J et. al.

Jan 29th, 2023 - RNA methylation (RM) is a crucial post-translational modification (PTM) that directs epigenetic regulation. It mostly consists of N1-methyladenosine (m1A), 5-methylcytosine (m5C), N3-methylcytidine (m3C), N6-methyladenosine (m6A), and 2'-O-methylation (Nm). The "writers" mainly act as intermediaries between these modifications and associated biological processes. However, little is known about ...

TRMT6 promotes hepatocellular carcinoma progression through the PI3K/AKT signaling path...
https://doi.org/10.1186/s40001-022-00951-1
European Journal of Medical Research; Ye Y, Liu M et. al.

Jan 29th, 2023 - Hepatocellular carcinoma is one of the most common and deadly cancers. The aim of this study was to elucidate the role of tRNA methyltransferase 6 (TRMT6) during HCC progression. The role of TRMT6 in the progression and prognosis of HCC was confirmed by analysis of online databases and clinical human samples. The effects of up-regulation or down-regulation of TRMT6 on HCC cell proliferation and...

Mitigation of therapeutic anti-CD38 antibody interference with fab fragments: How well ...
https://doi.org/10.1111/trf.17253
Transfusion Habicht CP, Ridders M et. al.

Jan 29th, 2023 - Administration of anti-CD38 antibodies is a state-of-the-art therapy for patients diagnosed with multiple myeloma (MM). However, this treatment frequently leads to pan-agglutination of red blood cells (RBCs) in patients' serological testing making accurate blood typing and timely transfusion of compatible blood a challenging effort. The antigen masking indirect antiglobulin test (AMIAT) is an a...

The pattern of MHC class I expression in muscle biopsies from patients with myositis an...
https://doi.org/10.1093/rheumatology/kead052
Rheumatology (Oxford, England); Milisenda JC, Pinal-Fernandez I et. al.

Jan 29th, 2023 - Diagnostic muscle biopsies are routinely immunostained for major histocompatibility complex class I (MHC-I) protein. In this study, we analyzed the prevalence and patterns of MHC-I immunostaining in biopsies from patients with different types of myopathies and neurogenic disorders. All 357 diagnostic muscle biopsies processed at the Johns Hopkins Neuromuscular Pathology Laboratory from August 2...

Seroprevalence of SARS-CoV2 Infections in Health Care Personnel in a Long-Term Care Ins...
https://doi.org/10.1177/21650799221135587
Workplace Health & Safety; Bautista Balbás LA, Sandino Gómez R et. al.

Jan 29th, 2023 - At the time of our study, occupational health evidence specific for long-term care employees was mostly lacking. The purpose of this study was to determine the proportion of positive cases in employees after the first COVID-19 wave in May 2020. We also determined the prevalence of asymptomatic cases. The study population included all health care workers (HCW) employed at one mid-size long-term ...

Failure to detect SARS-CoV-2 at RNA and protein level in the sweat of patients with COV...
https://doi.org/10.1093/bjd/ljac123
The British Journal of Dermatology; Gambichler T, Goesmann S et. al.

Jan 29th, 2023 - Failure to detect SARS-CoV-2 at RNA and protein level in the sweat of patients with COVID-19.|2023|Gambichler T,Goesmann S,Korte V,Skrygan M,Harnischfeger F,|

Extracellular vesicles: a comprehensive review of their roles as biomarkers and potenti...
https://doi.org/10.1093/ced/llac108
Clinical and Experimental Dermatology; Born LJ, Khachemoune A

Jan 29th, 2023 - Psoriasis is a chronic immune-mediated condition that affects the skin and joints, with current treatments still unable to offer a cure and long-term use of treatments posing health risks. Understanding the pathogenesis of the disease has helped identify new targets that have allowed for the expansion of the therapeutic arsenal. Extracellular vesicles (EVs) have recently emerged as pathophysiol...

Infections in travellers returning to the UK: a retrospective analysis (2015-2020).
https://doi.org/10.1093/jtm/taad003
Journal of Travel Medicine; Warner JC, Hatziioanou D et. al.

Jan 29th, 2023 - Every year, many thousands of travellers return to the United Kingdom (UK) from visits to other countries and some will become unwell due to infections acquired abroad. Many imported infections have similar clinical presentations, such as fever and myalgia, so diagnostic testing is an important tool to improve patient management and outcomes. The aim of this study was to examine the demographic...

L1CAM promotes vasculogenic mimicry formation by miR-143-3p-induced expression of hexok...
https://doi.org/10.1002/1878-0261.13384
Molecular Oncology; Huang Y, Zhu C et. al.

Jan 29th, 2023 - In recent decades, antiangiogenic therapy, which blocks the supply of oxygen and nutrition to tumor cells, has become a promising clinical strategy for the treatment of patients with tumors. However, recent studies revealed that vasculogenic mimicry (VM), which is the process by which vascular morphological structures are formed by highly invasive tumor cells, has been considered a potential fa...

Pediatric neurobrucellosis: a systematic review with case report.
https://doi.org/10.1093/tropej/fmad004
Journal of Tropical Pediatrics; Dhar D, Jaipuriar RS et. al.

Jan 29th, 2023 - Pediatric neurobrucellosis represents a common anthropozoonosis in endemic areas but only anecdotal reports are available till date. Using appropriate search terms in the database platforms of MEDLINE, SCOPUS and Web of Sciences, we performed a systematic review of all the cases of pediatric neurobrucellosis published in the medical literature till date, in the light of a case report. The proto...

The effects of altered DNA damage repair genes on mutational processes and immune cell ...
https://doi.org/10.1002/cam4.5663
Cancer Medicine; Yuan H, Qing T et. al.

Jan 29th, 2023 - Defects in DNA damage repair (DDR) pathways lead to genomic instability and oncogenesis. DDR deficiency is prevalent in esophageal squamous cell carcinoma (ESCC), but the effects of DDR alterations on mutational processes and tumor immune microenvironment in ECSS remain unclear. Whole-exome and transcriptome sequencing data of 45 ESCC samples from Taizhou, China, were used to identify genomic v...

Identification of EMP1 as a critical gene for cisplatin resistance in ovarian cancer by...
https://doi.org/10.1002/cam4.5637
Cancer Medicine; Zeng Q, Yi C et. al.

Jan 29th, 2023 - Cisplatin resistance is among the main reasons for the poor prognosis of ovarian cancer (OC) patients. Until now, effective biomarkers for predicting cisplatin resistance in OC and specific drugs for reversing this resistance are lacking. This study identified the critical gene associated with cisplatin resistance in OC and provided a potential target for overcoming this resistance. Differentia...