×
About 1,898,538 results

The uncommon forms of congenital adrenal hyperplasia.
https://doi.org/10.1097/MED.0000000000000727
Current Opinion in Endocrinology, Diabetes, and Obesity; Auchus RJ

May 28th, 2022 - Clinicians recognize 21-hydroxylase deficiency as the most common form of congenital adrenal hyperplasia (CAH), and many papers have been published on this condition. In contrast, much less awareness has been addressed to the other, rare forms of CAH. The second most common form of CAH varies with country and ethnic background. In Brazil, 17-hydroxylase/17,20-lyase deficiency is the second most...

Depressive and anxious symptoms among young adults in the COVID-19 pandemic: Results fr...
https://doi.org/10.1002/da.23273
Depression and Anxiety; Kreski NT, Keyes KM et. al.

May 28th, 2022 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is associated with worsening mental health among young adults, but further research is necessary to quantify the associations with depression and anxiety. Using Monitoring the Future data (N = 1244 young adults, modal age: 19, Fall 2020 supplement), we examined internalizing symptoms (Patient Health Questionnaire-8 and Ge...

Social deficits in BTBR T+ Itpr3tf/J mice vary with ecological validity of the test.
https://doi.org/10.1111/gbb.12814
Genes, Brain, and Behavior; Winiarski M, Kondrakiewicz L et. al.

May 28th, 2022 - Translational value of mouse models of neuropsychiatric disorders depends heavily on the accuracy with which they replicate symptoms observed in the human population. In mouse models of autism spectrum disorder (ASD) these include, among others, social affiliation, and communication deficits as well as impairments in understanding and perception of others. Most studies addressing these issues i...

The 2021 EULAR/American College of Rheumatology Points to Consider for Diagnosis, Manag...
https://doi.org/10.1002/art.42139
Arthritis & Rheumatology (Hoboken, N.J.); Romano M, Arici ZS et. al.

May 28th, 2022 - The interleukin-1 (IL-1) mediated systemic autoinflammatory diseases, including the cryopyrin- associated periodic syndromes (CAPS), tumour necrosis factor receptor-associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD) and deficiency of the IL-1 receptor antagonist (DIRA), belong to a group of rare immunodysregulatory diseases that primarily present in early childhood with va...

Efficacy and safety of combined Fractional ablative CO2 laser and 5 fluorouracil (5-FU)...
https://doi.org/10.1111/jocd.15116
Journal of Cosmetic Dermatology; Weshahy R, Abdelhamid MF et. al.

May 28th, 2022 - Acral lesions of vitiligo are most likely recalcitrant to the known lines of treatment. Ablative fractional CO2 has shown efficacy in treatment of vitiligo in combination with other modalities. Thirty non-segmental vitiligo patients with acral lesion were included in the study. Each patient was subjected to fractional Carbon Dioxide Laser Treatment followed by application of 5 fluorouracil (5FU...

The characteristics and clinical relevance of tumor fusion burden in head and neck squa...
https://doi.org/10.1002/cam4.4890
Cancer Medicine; He L, Ren D et. al.

May 28th, 2022 - Recent studies suggest that tumor fusion burden (TFB) is a hallmark of immune infiltration in prostate cancer, the correlation of TFB with immune microenvironment, and genomic patterns in head and neck squamous cell carcinomas (HNSC) remain largely unclear. Gene fusion, genomic, transcriptomic, and clinical data of HNSC patients from the cancer genome atlas (TCGA) database were collected to ana...

Cardiovascular Magnetic Resonance for Rejection Surveillance After Cardiac Transplantat...
https://doi.org/10.1161/CIRCULATIONAHA.121.057006
Circulation Anthony C, Imran M et. al.

May 28th, 2022 - Endomyocardial biopsy (EMB) is the gold standard method for surveillance of acute cardiac allograft rejection (ACAR) despite its invasive nature. Cardiovascular magnetic resonance (CMR)-based myocardial tissue characterization allows detection of myocarditis. The feasibility of CMR-based surveillance for ACAR-induced myocarditis in the first year after heart transplantation is currently undescr...

A homozygous exonic variant leading to exon skipping in ABCC8 as the cause of severe co...
https://doi.org/10.1002/ajmg.a.62843
American Journal of Medical Genetics. Part A; Reyes Diaz JV, Jin Y et. al.

May 28th, 2022 - Congenital hyperinsulinism (CHI) is genetically heterogeneous, caused by pathogenic variants in multiple known genes regulating insulin secretion from the pancreatic β-cells. The ABCC8 gene encodes the sulfonylurea receptor 1 (SUR1), a key player in insulin secretion, and pathogenic variants in ABCC8 are the most common cause of CHI. With increased application of genetic testing in clinical pra...

Efficacy and safety of metformin in pregnant women with polycystic ovary syndrome: a sy...
https://doi.org/10.1080/09513590.2022.2080194
Gynecological Endocrinology : the Official Journal of The... Zhao Q, He J

May 28th, 2022 - To evaluate the efficacy and safety of using metformin in pregnant women with polycystic ovarian syndrome (PCOS) and to explore the most effective and safe protocol by using a meta-analysis method. Medline, EMBASE, Cochrane Library, and other databases were searched for randomized controlled trials and prospective cohort studies enrolling pregnant women with PCOS on receiving metformin or place...

Pharmacologic Treatment and Management of Bipolar Disorder in Adolescents.
https://doi.org/10.1080/14656566.2022.2083954
Expert Opinion on Pharmacotherapy; Elsayed OH, Pahwa M et. al.

May 28th, 2022 - The importance of the appropriate therapeutic interventions in children and adolescents with bipolar disorder (BD) cannot be overstated since treatment choices and their consequences may have effects into adulthood. Randomized clinical trials (RCTs) investigating treatment of mania, bipolar depression, and maintenance in adolescents with BD are reviewed. When RCTs are not available or are inade...

Evaluating fostamatinib disodium as a treatment option for immune thrombocytopenia in a...
https://doi.org/10.1080/14656566.2022.2082283
Expert Opinion on Pharmacotherapy; Dierickx D, Neefs J

May 28th, 2022 - Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by increased platelet destruction and decreased platelet production, leading to thrombocytopenia with or without bleeding manifestations. The majority of patients experiencing treatment need will eventually need secondary treatment following first line therapy with steroids. In 2018, the oral spleen tyrosine kinase i...

Immunoediting Removes High-Quality Neoantigens in Pancreatic Cancer.
https://doi.org/10.1158/2159-8290.CD-RW2022-098
Cancer Discovery;

May 28th, 2022 - Recurrent tumors in long-term survivors of pancreatic cancer have less high-quality neoantigens.

Innovations in the Management of Vaginal Cancer.
https://doi.org/10.3390/curroncol29050250
Current Oncology (Toronto, Ont.); Kulkarni A, Dogra N et. al.

May 28th, 2022 - Primary vaginal cancer is a rare gynecologic malignancy. Given the rarity of the disease, standardized approaches to management are limited, and a great variety of therapeutic conditions are endorsed. This paper reviews advances in surgical approaches, radiation, chemoradiation, and immunotherapy. Advances in surgical management including the increasing use of laparoscopic and endoscopic approa...

Current Role of Immunotherapy in Gastric, Esophageal and Gastro-Esophageal Junction Can...
https://doi.org/10.3390/curroncol29050257
Current Oncology (Toronto, Ont.); Mulder K, Lim H et. al.

May 28th, 2022 - Gastric, esophageal and gastro-esophageal junction cancers are associated with inferior outcomes. For early-stage disease, perioperative chemotherapy or chemoradiation followed by surgery is the standard treatment. For most patients with advanced upper gastrointestinal tract cancers, platinum-based chemotherapy remains a standard treatment. Recently, several randomized clinical trials have demo...

Histologic and Genotypic Characterization of Lung Cancer in the Inuit Population of the...
https://doi.org/10.3390/curroncol29050258
Current Oncology (Toronto, Ont.); Goss GD, Spaans JN et. al.

May 28th, 2022 - Inuit are the Indigenous Arctic peoples and residents of the Canadian territory of Nunavut who have the highest global rate of lung cancer. Given lung cancer's mortality, histological and genomic characterization was undertaken to better understand the disease biology. We retrospectively studied all Inuit cases from Nunavut's Qikiqtani (Baffin) region, referred to the Ottawa Hospital Cancer Cen...

Invasive Fungal Disease in Patients with Chronic Lymphocytic Leukemia in Japan: A Retro...
https://doi.org/10.3390/curroncol29050264
Current Oncology (Toronto, Ont.); Yasu T, Sakurai K et. al.

May 28th, 2022 - Invasive fungal disease (IFD) is an important cause of morbidity and mortality in patients with hematological malignancies. As chronic lymphocytic leukemia (CLL) is a rare hematological malignancy in Japan, IFD incidence in Japanese patients with CLL is unclear. This study aimed to investigate IFD incidence in Japanese patients with CLL. This retrospective cohort study used data of patients wit...

Primary Angiosarcoma of the Breast: A Single-Center Retrospective Study in Korea.
https://doi.org/10.3390/curroncol29050267
Current Oncology (Toronto, Ont.); Kim YJ, Ryu JM et. al.

May 28th, 2022 - Due to the rarity of primary angiosarcoma of the breast, optimal management is based on expert opinion. The aim of this study was to review all primary angiosarcomas of the breast obtained from a single center in terms of clinicopathologic characteristics, treatment, and survival outcomes. From 1997 to 2020, 15 patients with primary angiosarcoma of the breast underwent either mastectomy or wide...

Identification of CT Values That Could Be Predictive of Necrosis (N-CTav) in Hepatocell...
https://doi.org/10.3390/curroncol29050266
Current Oncology (Toronto, Ont.); Chuma M, Yokoo H et. al.

May 28th, 2022 - To assess the utility of measurement of the computed tomography (CT) attenuation value (CTav) in predicting tumor necrosis in hepatocellular carcinoma (HCC) patients who achieve a complete response (CR), defined using modified Response Evaluation Criteria in Solid Tumors (mRECIST), after lenvatinib treatment. We compared CTav in arterial phase CT images with postoperative histopathology in four...

Understanding the Experience of Canadian Women Living with Ovarian Cancer through the E...
https://doi.org/10.3390/curroncol29050271
Current Oncology (Toronto, Ont.); Tone A, Boghosian T et. al.

May 28th, 2022 - The Every Woman StudyTM: Canadian Edition is the most comprehensive study to date exploring patient-reported experiences of ovarian cancer (OC) on a national scale. An online survey conducted in Fall 2020 included individuals diagnosed with OC in Canada, reporting responses from 557 women from 11 Canadian provinces/territories. Median age at diagnosis was 54 (11-80), 61% were diagnosed between ...

AML with inv(16)/t(16;16) and high-risk cytogenetic abnormalities: atypical features an...
https://doi.org/10.1080/16078454.2022.2078027
Hematology (Amsterdam, Netherlands); Assaf N, Lefebvre C et. al.

May 28th, 2022 - Acute myeloid leukemia (AML) with inv(16)/t(16;16) is among the most frequent AML subtypes. It is recognized by the detection of the CBFB-MYH11 fusion which confers a favorable prognosis, irrespective of the presence of secondary cytogenetic abnormalities. However, the effect of additional genetic anomalies on the behavior of inv(16) AML is debatable. Recent case reports describe an unfavorable...