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About 1,898,360 results

Hamartochondroma Pleural Lesion Mimicking Liposarcoma: A Case Report.
https://doi.org/10.3390/curroncol29050281
Current Oncology (Toronto, Ont.); Drevet G, Kovacs E et. al.

May 28th, 2022 - Heterogeneous masses developing in the pleural cavity are most often malignant and can pose diagnostic challenges. Fibrous tumors of the pleura, liposarcoma, thymoma or lipoma most frequently affect this anatomic area. Surgical exploration and resection are often mandatory to make the definitive diagnosis. We report the case of a 54-year-old women who presented with an epigastric and right sub ...

The Role of Microorganisms in Appendiceal Pseudomyxoma Peritonei: A Review.
https://doi.org/10.3390/curroncol29050289
Current Oncology (Toronto, Ont.); Khamzina Y, King MC et. al.

May 28th, 2022 - Pseudomyxoma peritonei (PMP) is a rare clinical syndrome. It originates from neoplasms of the appendix and leads to the formation of peritoneal implants and the accumulation of mucinous ascites. PMP represents a spectrum of low to high-grade disease. Despite aggressive management, many PMP patients recur, leading to debilitating symptoms and few treatment options. Therefore, scientists have con...

CAR T Cell Therapy for Chronic Lymphocytic Leukemia: Successes and Shortcomings.
https://doi.org/10.3390/curroncol29050293
Current Oncology (Toronto, Ont.); Todorovic Z, Todorovic D et. al.

May 28th, 2022 - Chimeric antigen receptor T (CAR T) cell therapy achieved remarkable success in B-cell leukemia and lymphoma which led to its incorporation in treatment protocols for these diseases. CAR T cell therapy for chronic lymphocytic leukemia (CLL) patients showed less success compared to other malignant tumors. In this review, we discuss the published results regarding CAR T cell therapy of CLL, possi...

De-Escalation Strategies for Human Papillomavirus-Associated Oropharyngeal Squamous Cel...
https://doi.org/10.3390/curroncol29050295
Current Oncology (Toronto, Ont.); Silver JA, Turkdogan S et. al.

May 28th, 2022 - The prevalence of oropharyngeal squamous cell carcinoma has been increasing in North America due to human papillomavirus-associated disease. It is molecularly distinct and differs from other head and neck cancers due to the young population and high survival rate. The treatment regimens currently in place cause significant long-term toxicities. Studies have transitioned from mortality-based out...

Gemcitabine and Cisplatin as Neo-Adjuvant for Cholangiocarcinoma Patients Prior to Live...
https://doi.org/10.3390/curroncol29050290
Current Oncology (Toronto, Ont.); Abdelrahim M, Al-Rawi H et. al.

May 28th, 2022 - The management of cholangiocarcinoma is continually reviewed on a current evidence basis to develop practice guidelines and consensus statements. However, the standardized treatment guidelines are still unclear for cholangiocarcinoma patients who are listed for liver transplantation. We aimed to validate and evaluate the potential efficacy of chemotherapy combination of Gemcitabine and Cisplati...

Treatment Outcomes for Primary Hepatic Angiosarcoma: National Cancer Database Analysis ...
https://doi.org/10.3390/curroncol29050292
Current Oncology (Toronto, Ont.); Mangla A, Cioffi G et. al.

May 28th, 2022 - To determine the risk of mortality and factors associated with survival amongst patients diagnosed with primary hepatic angiosarcoma (PHA). All patients diagnosed with hepatocellular carcinoma (HCC) or PHA from 2004 to 2014 were identified from the National Cancer Database (NCDB). Further analysis was performed within the cohort of patients with PHA to assess the impact of surgery, chemotherapy...

Patient Experience with a Gynecologic Oncology-Initiated Genetic Testing Model for Wome...
https://doi.org/10.3390/curroncol29050288
Current Oncology (Toronto, Ont.); Sadinsky MB, Power J et. al.

May 28th, 2022 - Up to 20% of women diagnosed with tubo-ovarian carcinoma carry a germline pathogenic variant in a cancer-predisposing gene (e.g., BRCA1/BRCA2). Identifying these variants can help to inform eligibility for therapies, guide surveillance and prevention of new primary cancers, and assess risk to family members. The Gynecologic Oncology-Initiated Genetic Testing Model (GOIGT) was initiated at the M...

The Effect of Surgeon Volume on the Outcome of Laser Vaporization: A Single-Center Retr...
https://doi.org/10.3390/curroncol29050302
Current Oncology (Toronto, Ont.); Maeda M, Hisa T et. al.

May 28th, 2022 - Although laser vaporization is a popular minimally invasive treatment for cervical intraepithelial neoplasia (CIN), factors influencing CIN recurrence are understudied. Moreover, the effect of surgeon volume on patients' prognosis after laser vaporization for CIN is unknown. This single-center retrospective study evaluated the predictive value of surgeon volume and patient characteristics for l...

Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion and ...
https://doi.org/10.1158/1078-0432.CCR-21-3039
Clinical Cancer Research : an Official Journal of the Ame... Wang W, Lozar T et. al.

May 28th, 2022 - We investigated whether in human head and neck squamous cell carcinoma (HNSCC) high levels of expression of stress keratin 17 (K17) are associated with poor survival and resistance to immunotherapy. We investigated the role of K17 in regulating both the tumor microenvironment and immune responsiveness of HNSCC using a syngeneic mouse HNSCC model, MOC2. MOC2 gives rise to immunologically cold tu...

Nucleophosmin 1: from its pathogenic role to a tantalizing therapeutic target in acute ...
https://doi.org/10.1080/16078454.2022.2067939
Hematology (Amsterdam, Netherlands); Shi Y, Xue Y et. al.

May 28th, 2022 - Nucleophosmin 1 (NPM1, also known as B23) is a multifunctional protein involved in a variety of cellular processes, including ribosomal maturation, centrosome replication, maintenance of genomic stability, cell cycle control, and apoptosis. NPM1 is the most commonly mutated gene in adult acute myeloid leukemia (AML) and is present in approximately 40% of all AML cases. The underlying mechanisms...

A Review of Disease Mechanisms and Current and Emerging Treatment Options for Generaliz...
https://doi.org/10.4088/PCC.AR21018WC2C
The Primary Care Companion for CNS Disorders; Bril V, Silvestri NJ et. al.

May 28th, 2022 - Generalized myasthenia gravis (gMG) is a disease resulting from impaired neuromuscular transmission due to presence of antibodies that block acetylcholine receptors. Autoantibodies to acetylcholine receptors directly impair the activity of ion channels that conduct nerve impulses, and cross-link acetylcholine receptors resulting in complement-mediated destruction, further worsening functional i...

Clinical risk factors for patients with myelodysplastic syndromes undergoing allogeneic...
https://doi.org/10.1080/16078454.2022.2052601
Hematology (Amsterdam, Netherlands); Teshigawara-Tanabe H, Hagihara M et. al.

May 28th, 2022 - Objectives: Allogeneic hematopoietic stem cell transplantation (allo-HCT) is the only curative treatment for myelodysplastic syndromes (MDS), although predicting post-transplant outcomes remains inconclusive. This study evaluated patients who underwent allo-HCT for MDS to identify prognostic factors and develop a clinical risk model.Methods: We evaluated 55 patients between June 2000 and March ...

Fueling the fire in the gut.
https://doi.org/10.1084/jem.20220723
The Journal of Experimental Medicine; Lin CH, Lu LF

May 28th, 2022 - Gut dysbiosis has long been associated with the development of Crohn's disease and other gastrointestinal disorders. Otake-Kasamoto et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20211291) report that dysbiotic microbiota-derived bioactive lipids, lysophosphatidylserines, can promote pathological Th1 cell responses through inducing metabolic reprogramming and epigenetic changes.

6 and 12-Month Outcomes After 90:10 Enteral Nutrition Induction Therapy in Pediatric Cr...
https://doi.org/10.1097/MPG.0000000000003475
Journal of Pediatric Gastroenterology and Nutrition; Davidson N, Rutsky J et. al.

May 28th, 2022 - Studies describing longer-term outcomes after EEN induction are limited. We describe clinical outcomes during 90:10 EN induction, and 6- and 12- month outcomes among patients that successfully completed EN induction and then continued either EN or immunomodulator (IM) maintenance therapy. All children with CD treated with 90:10 EN induction protocol (90% formula:10% regular diet) at our IBD Cen...

Identification of a Germline Pyrin Variant in a Metastatic Melanoma Patient With Multip...
https://doi.org/10.1097/CJI.0000000000000425
Journal of Immunotherapy (Hagerstown, Md. : 1997); Oswalt CJ, Al-Rohil RN et. al.

May 28th, 2022 - The mechanisms underlying tumor immunosurveillance and their association with the immune-related adverse events (irAEs) associated with checkpoint inhibitor immunotherapies remain poorly understood. We describe a metastatic melanoma patient exhibiting multiple episodes of spontaneous disease regression followed by the development of several irAEs during the course of anti-programmed cell death ...

AML with inv(16)/t(16;16) and high-risk cytogenetic abnormalities: atypical features an...
https://doi.org/10.1080/16078454.2022.2078027
Hematology (Amsterdam, Netherlands); Assaf N, Lefebvre C et. al.

May 28th, 2022 - Acute myeloid leukemia (AML) with inv(16)/t(16;16) is among the most frequent AML subtypes. It is recognized by the detection of the CBFB-MYH11 fusion which confers a favorable prognosis, irrespective of the presence of secondary cytogenetic abnormalities. However, the effect of additional genetic anomalies on the behavior of inv(16) AML is debatable. Recent case reports describe an unfavorable...

ASO Author Reflections: Importance of Preoperative Diagnosis of Lymph Node Metastasis i...
https://doi.org/10.1245/s10434-022-11933-2 10.1007/s00268-018-4654-2 10.1097/SLA.0000000000000584 10.1002/jhbp.1044 10.1016/j.hpb.2018.08.017 10.1007/s00276-018-2135-9 10.1245/s10434-020-08306-y 10.1245/s10434-020-08445-2 10.1245/s10434-022-11931-4
Annals of Surgical Oncology; Hosokawa I, Togasaki K et. al.

May 28th, 2022 - ASO Author Reflections: Importance of Preoperative Diagnosis of Lymph Node Metastasis in Perihilar Cholangiocarcinoma.|2022|Hosokawa I,Togasaki K,Ohtsuka M,|

Impact of Body Mass Index and Sarcopenia on Short- and Long-Term Outcomes After Esophag...
https://doi.org/10.1245/s10434-022-11944-z 10.1097/SLA.0b013e31821111b5 10.1093/annonc/mdx810 10.1007/s00432-014-1878-x 10.1038/bjc.2013.666 10.1097/MD.0000000000004204 10.1007/s11605-014-2686-y 10.1111/1759-7714.12340 10.1159/000453044 10.1245/s10434-013-3073-8 10.1097/SLA.0000000000002252 10.21873/anticanres.14060 10.1093/dote/doy104 10.1016/j.ejso.2016.11.015 10.1038/s41598-017-14147-9 10.1097/EDE.0b013e3181577654 10.1245/s10434-017-6077-y 10.1016/j.jtcvs.2018.06.098 10.1007/s10047-019-01108-4 10.1111/codi.12805 10.7570/jomes.2019.28.1.40 10.1097/EJA.0000000000000118 10.1016/j.surg.2013.12.001 10.1016/j.athoracsur.2016.04.005 10.1007/s10388-019-00670-3 10.1097/SLA.0000000000002555 10.1016/S1470-2045(08)70153-0 10.1016/j.clnu.2015.05.011 10.1016/j.cell.2011.02.013 10.1016/j.cell.2010.01.025 10.1093/ajcn/80.1.193 10.1128/mBio.01032-13 10.1093/eurheartj/ehq448 10.1016/j.ccell.2014.09.003 10.1016/j.clnu.2009.12.011 10.1016/j.ebiom.2019.10.034 10.1093/jnci/dju124 10.1016/j.amjmed.2007.05.011 10.1510/icvts.2010.256677 10.1212/WNL.0b013e318266fad1 10.1161/STROKEAHA.110.593434 10.1038/ijo.2011.187 10.1016/j.clnu.2009.12.004 10.1093/ageing/afy169 10.1002/jcsm.12221
Annals of Surgical Oncology; Kim GW, Nam JS et. al.

May 28th, 2022 - The effects of specific body mass index (BMI) category and sarcopenia within each BMI category on outcomes in patients undergoing esophageal surgery with esophageal squamous cell carcinoma have not been thoroughly examined. This study included 1141 patients. Sarcopenia was determined with a total psoas muscle cross-sectional area at the level of the third lumbar vertebra in computed tomography....

68Ga-DOTA-FAPI-04 PET/CT Imaging of Tracheal Mucoepidermoid Carcinoma.
https://doi.org/10.1097/RLU.0000000000004293
Clinical Nuclear Medicine; Peng D, Chen Q et. al.

May 28th, 2022 - A 23-year-old woman presented with a dry cough and dyspnea. Contrast-enhanced CT revealed an intratracheal space-occupying lesion with continuous homogeneous enhancement and airway stenosis. The patient then underwent 68Ga-DOTA-FAPI-04 PET/CT, which showed increased uptake of FAPI-04 by the lesion. Postoperative pathology confirmed the lesion as tracheal mucoepidermoid carcinoma. This case repo...

Diffuse Bone Marrow Involvement of Multiple Myeloma on 18FPSMA-1007 PET/CT: Is There a ...
https://doi.org/10.1097/RLU.0000000000004286
Clinical Nuclear Medicine; Michalski K, Jilg CA et. al.

May 28th, 2022 - A 71-year-old man presented with chronic anemia (hemoglobin 7.3 g/dL). Further serum analyses showed elevated prostate-specific antigen (13 ng/mL), suggestive of prostate cancer. However, ultrasound-guided transrectal sextant biopsy did not find any evidence of prostate cancer. In order to improve guidance of intended repeated biopsy, [18F]prostate-specific membrane antigen (PSMA) 1007 PET/CT w...