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About 2,366,035 results

A large outbreak of COVID-19 linked to an end of term trip to Menorca (Spain) by second...
https://doi.org/10.1371/journal.pone.0280614
PloS One; Forcadell-Díez L, Rius C et. al.

Feb 4th, 2023 - An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred in young people from Catalonia (Spain) who travelled to Menorca (Spain) in summer 2021. This outbreak appeared when governments relaxed Covid-19 preventive measures: the mask usage and the opening of nightlife. It was related to a super-disseminating mass event: Sant Joan festivities in Ciutadella. The aim of t...

A risk scoring model to predict progression of retinopathy of prematurity for Indonesia.
https://doi.org/10.1371/journal.pone.0281284
PloS One; Siswanto JE, Adisasmita AC et. al.

Feb 4th, 2023 - Retinopathy of prematurity (ROP) is a serious eye disease in preterm infants. Generally, the progression of this disease can be detected by screening infants regularly. In case of progression, treatment can be instituted to stop the progression. In Indonesia, however, not all infants are screened because the number of pediatric ophthalmologists trained to screen for ROP and provide treatment is...

How cardiac magnetic resonance is changing the management of myocarditis.
https://doi.org/10.1093/eurheartj/ehad013
European Heart Journal; Gräni C

Feb 4th, 2023 - How cardiac magnetic resonance is changing the management of myocarditis.|2023|Gräni C,|

Younger Haploidentical Donor Versus Older Matched Unrelated Donor for Patients With AML...
https://doi.org/10.1002/ajh.26870
American Journal of Hematology; Marcoux C, Marin D et. al.

Feb 4th, 2023 - Optimal donor selection is fundamental to successful allogeneic hematopoietic cell transplantation (HCT), and donor age influences survival after both matched unrelated donor (MUD) and haploidentical donor HCT. Though recent studies have shown similar outcomes between MUD and haploidentical HCT, it is unknown if outcomes differ following HCT with younger haploidentical donors compared to HCT wi...

Randomised clinical trial: Psychological intervention improves work productivity and da...
https://doi.org/10.1111/apt.17399
Alimentary Pharmacology & Therapeutics; Regev S, Schwartz D et. al.

Feb 4th, 2023 - Chronic abdominal pain and fatigue are characteristics of Crohn's disease (CD) and contribute to functional impairments. To examine whether CD-tailored cognitive-behavioural and mindfulness intervention (COBMINDEX) is effective in reducing abdominal pain and fatigue in patients with CD and whether changes in abdominal pain and fatigue mediate any beneficial effects of COBMINDEX on impairments i...

EBV-Gastritis Preceded the Development of Nasopharyngeal EBV (+) Diffuse Large B Cell L...
https://doi.org/10.1177/10668969221137525
International Journal of Surgical Pathology; Puello Yocum B, Mesa H et. al.

Feb 4th, 2023 - Epstein-Barr virus (EBV) is acquired early in life as asymptomatic or symptomatic infectious mononucleosis (IM) and remains latent in a few B cells in most individuals. Pathologic EBV-reactivation affects immunosuppressed individuals and manifests as IM-like syndromes, polyclonal lymphoproliferative disorders, EBV-related lymphomas, and carcinomas. EBV-associated gastritis is an underrecognized...

Effectiveness of a neonatal intensive care unit-specific antimicrobial stewardship prog...
https://doi.org/10.1017/ice.2022.318
Infection Control and Hospital Epidemiology; Assen KH, Paquette V et. al.

Feb 4th, 2023 - To evaluate the change in consumption of specific antibiotics in a neonatal intensive care unit after the implementation of an antimicrobial stewardship program (ASP). Retrospective cohort study between January 1, 2010, and December 31,2019. The neonatal intensive care unit at British Columbia Women's Hospital (Vancouver Canada), a tertiary-care center. Admitted neonates prescribed antibiotics....

A SARS-CoV-2 outbreak associated with five air force bases and a nightclub following th...
https://doi.org/10.1017/S0950268823000134
Epidemiology and Infection; Taylor MJ, Kumbang J et. al.

Feb 4th, 2023 - A SARS-CoV-2 outbreak associated with five air force bases and a nightclub following the lifting of COVID-19-related social restrictions, United Kingdom, July-to-September 2021.|2023|Taylor MJ,Kumbang J,Bamford K,Ismail H,Huntley P,|

Features of T1 pancreatic cancer and validation of the eighth edition AJCC staging syst...
https://doi.org/10.1002/jhbp.1316
Journal of Hepato-biliary-pancreatic Sciences; Kwon W, Heo JS et. al.

Feb 4th, 2023 - Little is known about the features of T1 pancreatic ductal adenocarcinoma (PDAC) and its definition in the eighth edition of the American Joint Committee on Cancer (AJCC) staging system needs validation. The aims were to analyze the clinicopathologic features of T1 PDAC and investigate the validity of its definition. Data from 1,506 patients with confirmed T1 PDAC between 2000 and 2019 were col...

Mutation of FLNA attenuating the migration of abdominal muscles contributed to Melnick-...
https://doi.org/10.1002/mgg3.2145
Molecular Genetics & Genomic Medicine; Luo X, Yang Z et. al.

Feb 4th, 2023 - Filamin A, encoded by the X-linked gene FLNA, links the cell membrane with the cytoskeleton and acts as a regulator of the actin cytoskeleton. Mutations in FLNA cause a large spectrum of congenital malformations during embryonic development, including Melnick-Needles syndrome (MNS). However, reports of MNS, especially in males, are rare, and the pathogenesis molecular mechanisms are not well un...

Identifying the dominant variant of a cis-double-variant in COL1A1 from an osteogenesis...
https://doi.org/10.1002/jbmr.4783
Journal of Bone and Mineral Research : the Official Journ... Cao Y, Li L et. al.

Feb 4th, 2023 - Osteogenesis imperfecta (OI) is a hereditary skeletal disorder that is mainly caused by variants in COL1A1/2. So far, no specific treatment has been developed to correct its underlying etiology. We aimed to gain a better understanding of the pathological mechanisms of OI and develop gene editing techniques to correct OI-causing variants. A de novel cis-double-variant c.[175C>T;187T>A] in COL1A1...

Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy.
https://doi.org/10.1111/acel.13782
Aging Cell; Henpita C, Vyas R et. al.

Feb 4th, 2023 - Cardiomyopathy is a progressive disease of the myocardium leading to impaired contractility. Genotoxic cancer therapies are known to be potent drivers of cardiomyopathy, whereas causes of spontaneous disease remain unclear. To test the hypothesis that endogenous genotoxic stress contributes to cardiomyopathy, we deleted the DNA repair gene Ercc1 specifically in striated muscle using a floxed al...

Facilitating the Urgent Public Health Need to Improve Data Sharing With Tribal Epidemio...
https://doi.org/10.1177/00333549231152197
Public Health Reports (Washington, D.C. : 1974); O'Connell MC, Abourezk C

Feb 4th, 2023 - Tribal epidemiology centers (TECs) are an essential and unique part of the public health system and an important part of federal efforts to improve the health status of American Indian and Alaska Native people. Pursuant to federal statute, TECs serve the 574 federally recognized tribes (hereinafter, "tribes") and their members across the United States, as well as American Indian and Alaska Nati...

Investigation of SARS-CoV-2 Transmission in The Tabernacle Choir at Temple Square in th...
https://doi.org/10.1177/00333549231152198
Public Health Reports (Washington, D.C. : 1974); Lanier WA, Palmer DK et. al.

Feb 4th, 2023 - Group singing and playing of wind instruments increase COVID-19 transmission risk. After a pause during the initial period of the COVID-19 pandemic, The Tabernacle Choir at Temple Square organization (hereinafter, Choir) resumed musical events in September 2021 with prevention protocols, including required vaccination and pre-event rapid antigen testing. We investigated potential SARS-CoV-2 tra...

Adult intracranial ependymoma - relevance of DNA methylation profiling for diagnosis, p...
https://doi.org/10.1093/neuonc/noad030
Neuro-oncology Träger M, Schweizer L et. al.

Feb 4th, 2023 - A methylation-based classification of ependymoma has recently found broad application. However, the diagnostic advantage and implications for treatment decisions remain unclear. Here, we retrospectively evaluate the impact of surgery and radiotherapy on outcome after molecular reclassification of adult intracranial ependymomas. Tumors diagnosed as intracranial ependymomas from 170 adult patient...

Primary squamous cell carcinoma of the ovary accompanied by transition of a mucinous bo...
https://doi.org/10.1177/03000605221098177
The Journal of International Medical Research; Bak S, Hong JY et. al.

Feb 4th, 2023 - This report describes a woman with a rare primary squamous cell carcinoma of the ovary accompanied by transition of a mucinous borderline ovarian tumor. A woman in her late 40s was referred for abdominal discomfort, which worsened during defecation. Pelvic magnetic resonance imaging showed a multiloculated cystic lesion in the left adnexa measuring approximately 7.5 × 9.5 × 7.0 cm. An intraoper...

Multi-item Measures for Pediatric Inflammatory Bowel Diseases: The ABCs of All Those Ac...
https://doi.org/10.1093/ecco-jcc/jjad019
Journal of Crohn's & Colitis; Ledder O, Turner D

Feb 4th, 2023 - With the recent acceptance of multiple treatment goals for inflammatory bowel diseases (IBD), it becomes increasingly important to accurately quantify the measurable concepts. These include patient-reported symptoms, intestinal damage, mucosal activity, transmural inflammation, and histologic appearance, as well as quality of life, disability, and other patient-centered attributes. Standardized...

Shikonin improves pulmonary vascular remodeling in monocrotaline‑induced pulmonary arte...
https://doi.org/10.3892/mmr.2023.12947
Molecular Medicine Reports; Li W, Chen W et. al.

Feb 4th, 2023 - Pulmonary arterial hypertension (PAH), a fatal disease with an insidious onset and rapid progression, shows characteristics such as increases in pulmonary circulatory resistance and pulmonary arterial pressure, and progressive right heart failure. Shikonin can reduce right ventricular systolic pressure in chronically hypoxic mice. However, the mechanisms underlying the protective effect of shik...

AZD6738 promotes the tumor suppressive effects of trifluridine in colorectal cancer cells.
https://doi.org/10.3892/or.2023.8489
Oncology Reports; Harata S, Suzuki T et. al.

Feb 4th, 2023 - Ataxia telangiectasia and Rad3‑related (ATR) is a kinase that repairs DNA damage. Although inhibitors that selectively target ATR have been developed, their effectiveness in colorectal cancer has not been widely reported. The present study hypothesized that anticancer agents that effectively act in the S phase before the G2/M checkpoint may be ideal agents for concomitant use with ATR inhibitor...

Camptothecin improves sorafenib sensitivity by inhibiting Nrf2‑ARE pathway in hepatocel...
https://doi.org/10.3892/or.2023.8492
Oncology Reports; Sun L, Wang H et. al.

Feb 4th, 2023 - Sorafenib is a targeted drug for hepatocellular carcinoma (HCC), however, its efficacy is limited. Nuclear factor erythroid 2‑related factor 2 (Nrf2) contributes to sorafenib resistance. The present study investigated camptothecin (CPT) as a Nrf2 inhibitor to sensitize HCC to sorafenib. The effect of CPT on sorafenib sensitivity in HCC was assessed in vivo using H22 mice model (n=32) and VX2 ra...