The Oncologist; Saung MT, Pelosof L et. al.
May 11th, 2021 - On March 10, 2020, the FDA granted accelerated approval to nivolumab in combination with ipilimumab for the treatment of patients with hepatocellular carcinoma (HCC) previously treated with sorafenib. The recommended approved dosage was nivolumab 1 mg/kg intravenously (IV) plus ipilimumab 3 mg/kg IV every 3 weeks for four cycles, followed by nivolumab 240 mg IV every 2 weeks. The approval was b...
The Journal of Obstetrics and Gynaecology Research; Kaji T, Maeda K et. al.
May 11th, 2021 - Imperforate anus (IA) requires urgent treatment after birth, which is dependent on the type of IA, and is also frequently associated with other congenital abnormalities. Most patients with IA have an accompanying fistula, whose location is strongly associated with the type of IA. The fistula location can be a key factor in defining appropriate treatment, especially in neonates presenting with s...
Transplant Infectious Disease : an Official Journal of Th... Sharma R, Singh C et. al.
May 11th, 2021 - The role of pre-HCT chest high resolution computed tomography (HRCT) and serum galactomannan index (GMI) in predicting the post-allogeneic hematopoietic cell transplant (HCT) invasive pulmonary aspergillosis (IPA) is debatable. This was a single-center, prospective study from 2014-2019. The primary objective was to study if pre-HCT chest HRCT and serum GMI predicted IPA post-HCT. The secondary ...
American Journal of Medical Genetics. Part A; Martín-García D, Towler OW et. al.
May 11th, 2021 - Little is known about FOP in Africa and few cases of nonclassic fibrodysplasia ossificans progressiva (FOP) have been reported on the continent. Here we report a three-year-old girl from Angola with a nonclassic FOP clinical presentation that is characterized by complex malformations of the toes and fingers, reduction defects of the digits, absence of nails, progressive heterotopic ossification...
Arthritis Care & Research; Jin Y, Lee H et. al.
May 11th, 2021 - To compare the risk of serious infections requiring hospitalization in patients with psoriasis (PsO) or psoriatic arthritis (PsA) initiating ustekinumab versus other biologics or apremilast. In this multi-database cohort study, we identified patients with PsO/PsA who initiated adalimumab, apremilast, certolizumab, etanercept, golimumab, ixekizumab, secukinumab, or ustekinumab between 2009 and 2...
International Journal of Rheumatic Diseases; Santosa A, Xu C et. al.
May 11th, 2021 - People with rheumatic diseases (PRD) remain vulnerable in the era of the COVID-19 pandemic. We formulated recommendations to meet the urgent need for a consensus for vaccination against SARS-CoV-2 in PRD. Systematic literature reviews were performed to evaluate: (a) outcomes in PRD with COVID-19; (b) efficacy, immunogenicity and safety of COVID-19 vaccination; and (c) published guidelines/recom...
Arthritis Care & Research; Berenbaum F, Schnitzer TJ et. al.
May 11th, 2021 - This pooled analysis of 3 randomized, placebo-controlled trials (16─24 week treatment; 8─24 week follow-up) assessed safety of subcutaneous tanezumab (2.5─10 mg every 8 weeks) in 1840 patients with hip or knee osteoarthritis. Overall treatment-emergent adverse events (TEAEs) and TEAEs of abnormal peripheral sensation (APS) were prospectively assessed in 3 trials. Joint safety events (primary os...
Arthritis Care & Research; Paccou J, Bavière W et. al.
May 11th, 2021 - Little is known about body composition in patients with PsA. We compared body composition parameters in PsA patients and healthy controls, and then investigated the effects of ustekinumab (UST) on body composition in patients with PsA. At baseline, 30 PsA patients were compared cross-sectionnally with 60 non-PsA healthy controls matched for age, sex, menopausal status and body mass index. Thirt...
Arthritis Care & Research; Gaine S, Bongiorno DM et. al.
May 11th, 2021 - A Caucasian man with a history of autoimmune hepatitis on chronic prednisone therapy developed a rash over his chest, back, and upper extremities. He was evaluated by a dermatologist, who thought his scattered ill-defined, erythematous patches were consistent with an eczema flare. Topical steroids were prescribed.
Arthritis Care & Research; Furuya H, Nakajima M et. al.
May 11th, 2021 - The aim of this study was to determine the prognosis, clinical course, and current management of severe interstitial lung disease (ILD) associated with myositis in Japan. We conducted a retrospective descriptive study using a nation-wide database for inpatient care of acute illness in Japan. Among a total of approximately 66 million inpatient admissions, we identified patients with severe ILD a...
Arthritis Care & Research; Ben-Shabat N, Shabat A et. al.
May 11th, 2021 - In this large population-based study we aimed to assess:(1)mortality in ankylosing-spondylitis(AS) patients compared to the general population.Considering demographics,comorbidities and treatment.(2)factors associated with mortality within AS patients. This study was designed as a retrospective-cohort study utilizing the electronic-database of the largest health maintenance organization in Isra...
Arthritis Care & Research; Kaufman KP, Eudy AM et. al.
May 11th, 2021 - Systemic lupus erythematosus (SLE) patients have more pregnancy complications than healthy patients. Data regarding pregnancy outcomes in women with undifferentiated connective tissue disease (UCTD) are more limited, and existing studies are concentrated in Italy and predominantly in patients with a new diagnosis. We compared pregnancy outcomes for UCTD and SLE patients with established disease...
Arthritis Care & Research; Sneed RS, Mason M et. al.
May 11th, 2021 - Black patients with systemic lupus erythematous (SLE) experience greater disease incidence and severity than White patients yet are underrepresented in SLE clinical trials. We applied Critical Race Theory to qualitatively explore the influence of racism on the underrepresentation of Black patients in SLE clinical trials and to develop a framework for future intervention. We conducted groups in ...
The Cleft Palate-craniofacial Journal : Official Publicat... Badran S, Hassona Y
May 11th, 2021 - To identify research articles related to cleft lip and/or cleft palate (CL/P) that generated the highest online attention. Altmetric Explorer was used to identify the 100 articles with the highest Altmetric Attention Score (AAS). Descriptive and correlation statistics were performed to study the characteristics of these articles in relation to their publication data, research type and domain, n...
Ear, Nose, & Throat Journal; Kobayashi KR, Hajiyev Y et. al.
May 11th, 2021 - Rosai-Dorfman disease (RDD) is a rare benign systemic histiocytic proliferation characterized by massive lymph node enlargement and sometimes associated with extranodal involvement. Even though it is considered to be benign, death can occur depending on the extent and location. Our case highlights a primary extranodal site of the right pinna with extension through the Eustachian tube to the sub...
Disease Models & Mechanisms; Prins MMC, Giugliano FP et. al.
May 11th, 2021 - The ATG16L1 T300A single-nucleotide polymorphism (SNP) is associated with Crohn's disease and causes an autophagy impairment. We have previously shown that this SNP is involved in the migration and hyperactivation of Rac1 in dendritic cells. Mucosal healing, currently the main target for inflammatory bowel disease treatment, depends on restoration of the epithelial barrier and requires appropri...
Disease Models & Mechanisms; Oprişoreanu AM, Smith HL et. al.
May 11th, 2021 - Synapses are particularly vulnerable in many neurodegenerative diseases and often the first to degenerate, for example in the motor neuron disease spinal muscular atrophy (SMA). Compounds that can counteract synaptic destabilisation are rare. Here, we describe an automated screening paradigm in zebrafish for small-molecule compounds that stabilize the neuromuscular synapse in vivo. We make use ...
Magnetic Resonance in Medicine; Berks M, Little RA et. al.
May 11th, 2021 - We introduce a novel, generalized tracer kinetic model selection framework to quantify microvascular characteristics of liver and tumor tissue in gadoxetate-enhanced dynamic contrast-enhanced MRI (DCE-MRI). Our framework includes a hierarchy of nested models, from which physiological parameters are derived in 2 regimes, corresponding to the active transport and free diffusion of gadoxetate. We ...
Head & Neck; Yong M, Wu YQ et. al.
May 11th, 2021 - The incidence of cerebrospinal fluid leak after ventral skull base reconstruction is a primary outcome of interest to skull base surgeons. Exposure to pre-operative radiation may put patients at an increased risk of skull base reconstructive failure. A systematic search identified studies which included patients receiving ventral skull base reconstruction in the setting of pre-operative radiati...
American Journal of Medical Genetics. Part A; Semenza GL
May 11th, 2021 - Hypoxia-inducible factors (HIFs) activate gene transcription in response to reduced O2 availability and play critical roles in development, physiology, and disease pathogenesis. Mutations that dysregulate HIF activity are the genetic basis for tumor predisposition in the von Hippel-Lindau syndrome and excess red blood cell production in hereditary erythrocytosis.