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About 1,680,508 results

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Continuous-Release Anti-VEGF Device for AMD Wins FDA Approval
https://www.medpagetoday.com/ophthalmology/generalophthalmology/95225

Oct 23rd, 2021 - The FDA has approved a first-of-its kind continuous delivery system for anti-VEGF therapy for neovascular (wet) age-related macular degeneration (AMD). The Susvimo ocular implant continuously releases 100 mg/mL of ranibizumab directly to the retina over 6 months. Initial implantation and refill can be performed during an office visit with an ophthalmologist. In contrast, conventional intravitre...

Word Fluency Test Performance in Primary Progressive Aphasia and Primary Progressive Ap...
https://doi.org/10.1044/2021_AJSLP-21-00058
American Journal of Speech-language Pathology; Scheffel L, Duffy JR et. al.

Oct 23rd, 2021 - Purpose This study compared performance on three-word fluency measures among individuals with primary progressive aphasia (PPA) and primary progressive apraxia of speech (PPAOS), and examined the relationship between word fluency and other measures of language and speech. Method This study included 106 adults with PPA and 30 adults with PPAOS. PPA participants were divided into three clinical s...

Effects of Tham Nasal Alkalinization on Airway Microbial Communities: A Pilot Study in ...
https://doi.org/10.1177/00034894211051814
The Annals of Otology, Rhinology, and Laryngology; Holliday ZM, Launspach JL et. al.

Oct 23rd, 2021 - In cystic fibrosis (CF), loss of CFTR-mediated bicarbonate secretion reduces the airway surface liquid (ASL) pH causing airway host defense defects. Aerosolized sodium bicarbonate can reverse these defects, but its effects are short-lived. Aerosolized tromethamine (THAM) also raises the ASL pH but its effects are much longer lasting. In this pilot study, we tested the hypothesis that nasally ad...

Monitoring basal autophagy in the retina utilizing CAG-mRFP-EGFP-MAP1LC3B reporter mous...
https://doi.org/10.1080/15548627.2021.1969634
Autophagy Ramachandra Rao S, Fliesler SJ

Oct 23rd, 2021 - We describe the utility of a tandem-tagged autophagy reporter mouse model (CAG-RFP-EGFP-MAP1LC3B) in investigating basal macroautophagic/autophagic flux in the neural retina. Western blot, in situ hybridization, immunohistochemistry, and confocal microscopy showed that CAG promoter-driven expression of RFP-EGFP-MAP1LC3B increased "cytosolic" RFP-EGFP-LC3B-I levels, whereas RFP-EGFP-LC3B-II deco...

miR-149-3p suppressed epithelial-mesenchymal transition and tumor development in acute ...
https://doi.org/10.1080/16078454.2021.1990502
Hematology (Amsterdam, Netherlands); Tian Y, Jiang Y et. al.

Oct 23rd, 2021 - Acute myeloid leukemia (AML) is a form of primary acute leukemia with high mortality. Our previous study demonstrated that miR-149-3p was down-regulated in chemoresistant acute leukemia cells. However, the biological function of miR-149-3p in AML needs to be further explored. Herein, the expression of miR-149-3p was overexpressed/silenced in U-937 human AML cells via transfection with miR-149-3...

Clinical values of gene alterations as marker of minimal residual disease in non-M3 acu...
https://doi.org/10.1080/16078454.2021.1990503
Hematology (Amsterdam, Netherlands); Yu T, Chi J et. al.

Oct 23rd, 2021 - Acute myeloid leukemia (AML) is a malignant disease of the hematopoietic system. Residual leukemic cells after treatment are associated with relapse. Thus, detecting minimal residual disease (MRD) is significant. Major techniques for MRD assessment include multiparameter flow cytometry (MFC), polymerase chain reaction (PCR), and next-generation sequencing (NGS). At a molecular level, AML is the...

Assessment and Management of Loose Bodies in the Knee Joint and Related Disease: A Narr...
https://doi.org/10.2174/1573397117666211021165807
Current Rheumatology Reviews; Zmerly H, Moscato M et. al.

Oct 23rd, 2021 - Loose bodies are frequently encountered during clinical activity and a common finding during knee arthroscopy. Usually, treatment consists of the removal of the loose bodies, which can be challenging even for experienced surgeons. The excision alone is not always the complete treatment, because loose bodies are generally secondary to other diseases that can cause persistent symptoms with the ri...

Real-life isoniazid and rifampicin plasma concentrations in children: a tool for therap...
https://doi.org/10.1186/s12879-021-06764-7 10.4103/ijmr.IJMR_1961_16 10.1128/AAC.00693-15 10.1093/jac/dkv148 10.1080/17425255.2018.1416093 10.1111/apm.12590 10.1517/17425255.2016.1162785 10.1128/AAC.00756-15 10.1016/j.ijid.2014.12.001 10.1086/598192 10.1136/adc.2004.052175 10.1002/bmc.2920 10.1016/j.jpba.2007.10.025 10.1046/j.1445-5994.2003.00390.x 10.1136/adc.2004.052175 10.1159/000321045 10.1016/S0378-4347(01)00434-0 10.1093/jac/dku210 10.1016/j.ijantimicag.2017.12.004 10.1016/j.ijantimicag.2014.04.019 10.1086/598192 10.1128/AAC.05429-11 10.1371/journal.pone.0102047 10.1371/journal.pmed.1002595 10.1186/s41043-017-0132-y 10.1111/jpc.13458 10.2196/mhealth.8130 10.1186/s13063-019-3483-4 10.2196/mhealth.6837 10.3346/jkms.2020.35.e92 10.1080/02770903.2019.1635153 10.2217/pgs-2018-0166 10.1128/AAC.01833-10 10.1080/17512433.2017.1246179
BMC Infectious Diseases; Tersigni C, Boiardi G et. al.

Oct 23rd, 2021 - Low plasma levels of first-line antitubercular drugs can be counted among the main causes of poor response to antitubercular therapy, and therapeutic drug monitoring has been proposed as a method to promote tailored treatments for both child and adult patients. The main aim of the study was to evaluate serum concentrations of isoniazid (INH) and rifampicin (RIF) and to investigate reasons for s...

Multiple Immunofluorescence Imaging Analysis Reveals Differential Expression of Disialo...
https://doi.org/10.1177/10935266211048733
Pediatric and Developmental Pathology : the Official Jour... Nishimaki H, Nakanishi Y et. al.

Oct 23rd, 2021 - Peripheral neuroblastic tumors (pNTs) are the most common childhood extracranial solid tumors. There are several therapeutic strategies targeting disialoganglioside GD2. Disialoganglioside GD3 has become a potential target. However, the mechanism by which pNTs express GD3 and GD2 remains unclear. We investigated the combined expression status of GD3 and GD2 in pNTs and delineated their clinicop...

The T-type Calcium Channel Cav3.1 in Y79 Retinoblastoma Cells is Regulated by the Epide...
https://doi.org/10.1080/02713683.2021.1988982
Current Eye Research; Banderali U, Jain M et. al.

Oct 23rd, 2021 - Retinoblastoma is the most frequent intraocular cancer in children. It is also one of the most common causes for enucleation and carries a significant morbidity rate in affected individuals. Hence, studies on its pathophysiological and growth regulatory mechanisms are urgently needed to identify more effective novel therapeutics. Using the Y79 retinoblastoma cell line, we investigated the elect...

Hepatocellular carcinoma in nonalcoholic fatty liver disease with or without cirrhosis:...
https://doi.org/10.1186/s12876-021-01978-0 10.1002/hep.29546 10.1016/j.cgh.2018.05.057 10.1038/s41575-019-0145-7 10.1111/apt.14937 10.1002/hep.28368 10.1002/ijc.25797 10.1016/j.cgh.2011.01.023 10.1007/s12072-015-9679-0 10.1016/j.cgh.2015.07.019 10.1053/j.gastro.2018.08.024 10.1111/liv.14087 10.1111/apt.14261 10.1038/ajg.2011.327 10.1002/hep.29367 10.1111/jgh.14608 10.1136/amiajnl-2011-000782 10.1002/cam4.1998 10.1002/ijc.30784 10.18632/oncotarget.20127 10.1074/jbc.M112.348763 10.3389/fgene.2016.00168 10.1186/s12916-019-1321-x 10.1002/ijc.26165 10.1038/s41416-018-0007-z 10.1111/jebm.12270 10.1111/liv.12226 10.1111/hepr.12656 10.1016/j.cgh.2017.09.041 10.1002/hep.24397 10.1016/j.cgh.2008.02.012 10.1053/j.gastro.2008.03.073
BMC Gastroenterology; Pinyopornpanish K, Khoudari G et. al.

Oct 23rd, 2021 - There are limited data regarding the factors associated with hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) patients without cirrhosis. We sought to determine the prevalence and factors associated with HCC in NAFLD patients with or without cirrhosis. Adults with NAFLD (June 2015 to May 2020) were identified using the electronic health record database (Explorys Inc, ...

Reducing worry and rumination in young adults via a mobile phone app: study protocol of...
https://doi.org/10.1186/s12888-021-03536-0 10.1016/S0140-6736(11)60871-4 10.1001/archpsyc.62.6.593 10.1016/S0140-6736(14)61400-8 10.1016/j.jadohealth.2016.08.002 10.1007/s10964-014-0165-0 10.1017/S0033291715001725 10.1186/s12888-020-02857-w 10.1177/0963721413495872 10.1016/j.cbpra.2015.04.004 10.1001/jamapsychiatry.2017.0262 10.2196/mental.4984 10.2196/jmir.2791 10.1002/da.22654 10.1007/s11920-018-0910-2 10.1177/1754073915575406 10.1177/1754073915575404 10.1080/02699930902928969 10.1177/1754073915580601 10.1007/s10919-017-0269-9 10.1080/17439760.2015.1058968 10.1016/j.paid.2006.09.003 10.1146/annurev-clinpsy-032814-112739 10.1111/j.1758-0854.2011.01062.x 10.1521/ijct.2008.1.3.192 10.5127/jep.038813 10.1111/j.1745-6924.2008.00088.x 10.1016/j.brat.2020.103573 10.1037/0033-2909.134.2.163 10.1037/0021-843X.106.2.221 10.1023/A:1023914416469 10.1037/0022-3514.61.1.115 10.1023/A:1019873015594 10.1007/s10608-008-9191-0 10.1037/0021-843X.111.2.350 10.1037/1528-3542.1.1.25 10.1080/15374410802359627 10.1111/jcap.12102 10.1016/j.beth.2011.11.002 10.1016/j.paid.2015.06.034 10.1037/0022-3514.69.1.176 10.1016/j.beth.2006.03.003 10.1192/bjp.bp.110.090282 10.1017/S0033291711002480 10.1017/S0033291718003835 10.1016/j.brat.2016.12.015 10.2196/11349 10.1111/cpsp.12144 10.1016/j.brat.2016.09.011 10.7326/0003-4819-152-11-201006010-00232 10.1186/s13063-018-2735-z 10.2196/jmir.1923 10.1037/0022-3514.67.1.92 10.1016/0005-7967(90)90135-6 10.1046/j.1525-1497.2001.016009606.x 10.1136/jech.2011.143586.86 10.1186/1477-7525-5-63 10.1001/archinte.166.10.1092 10.1007/s10802-018-0401-2 10.1097/01.MLR.0000062554.74615.4C 10.1177/1740774512450098 10.1177/2167702615583840
BMC Psychiatry; Edge D, Newbold A et. al.

Oct 23rd, 2021 - Promoting well-being and preventing poor mental health in young people is a major global priority. Building emotional competence skills via a mobile app may be an effective, scalable and acceptable way to do this. A particular risk factor for anxiety and depression is elevated worry and rumination (repetitive negative thinking, RNT). An app designed to reduce RNT may prevent future incidence of...

Preemptive analgesic effectiveness of single dose intravenous ibuprofen in infants unde...
https://doi.org/10.1186/s12887-021-02907-6 10.1016/j.clp.2015.02.005 10.1016/B978-0-323-06612-9.00025-0 10.1111/j.0001-5172.2004.00407.x 10.1111/j.1365-2044.1995.tb04509.x 10.1597/1545-1569_2002_039_0145_aofpao_2.0.co_2 10.1213/00000539-199377020-00026 10.1016/j.joms.2018.09.010 10.1111/pan.12302 10.1097/00000539-200104000-00020 10.1111/pan.12393 10.1016/j.phrs.2011.08.010 10.1111/pan.12381 10.1016/0952-8180(94)00001-k 10.1542/peds.2007-0064 10.1046/j.1460-9592.2000.00530.x 10.1597/14-080 10.1111/j.1460-9592.2006.02018.x 10.1111/j.1460-9592.2010.03347.x 10.1093/bja/74.5.506 10.1111/j.1460-9592.2010.03262.x 10.1097/SCS.0000000000006633 10.1097/EJA.0000000000000900 10.1097/PEC.0000000000001505
BMC Pediatrics; Peng ZZ, Wang YT et. al.

Oct 23rd, 2021 - Correction surgery for cleft palate is recommended between 9 and 18 months of age. Patients suffer from acute pain after palatoplasty. Clinicians are hesitant to use opioids for analgesia concerning the potential high risk of respiratory adverse events. Intravenous ibuprofen perhaps be a suitable adjuvant to pain relief. We try to assess whether preoperative administration of intravenous ibupro...

Acceptability and feasibility of the school-engaged social and behavior change communic...
https://doi.org/10.1186/s12889-021-11995-z 10.1186/s12936-015-1047-y 10.1186/1475-2875-9-98 10.1186/1748-5908-5-67 10.1177/1098214012452715 10.1186/1748-5908-2-40 10.1007/s10488-010-0319-7 10.1186/s13012-017-0635-3 10.1007/s11121-015-0606-3 10.1186/s12889-021-11216-7 10.1371/journal.pone.0235189 10.1186/1478-4491-11-39 10.1111/napa.12064 10.1186/1748-5908-5-99 10.1002/jcop.20143 10.1093/heapro/dav059 10.1016/S0749-3797(98)00043-9 10.31899/rh4.1033 10.1007/s10464-008-9165-0 10.1093/heapro/dau016 10.1186/s13012-019-0941-z 10.2105/AJPH.2008.155234 10.1080/03637759209376276 10.1111/j.1460-2466.2001.tb02900.x 10.1177/001440291207800402 10.1007/s11121-008-0100-2 10.1186/s40814-019-0542-2 10.3200/PSFL.48.3.36-43 10.1016/j.jsp.2013.03.001 10.1080/02796015.2008.12087866
BMC Public Health; Abamecha F, Midaksa G et. al.

Oct 23rd, 2021 - Evidence on process outcomes such as acceptability, and feasibility of behavior change communication interventions are important in program evaluation to understand how, and why such a program works. However; documented evidence on the issue is not available as far as the social and behavior change communication (SBCC) on malaria is concerned. Enrolling the frontline providers this study measur...

Comparison of thyroid function in different emotional states of drug-naïve patients wit...
https://doi.org/10.1186/s12902-021-00869-5 10.1038/nrdp.2018.8 10.1001/archgenpsychiatry.2011.12 10.1053/comp.2001.23143 10.1080/03007995.2019.1636017 10.1111/j.1399-5618.2008.00581.x 10.1016/j.jad.2017.09.011 10.1111/j.1399-5618.2007.00327.x 10.1111/acps.12003 10.1038/mp.2010.101 10.3390/medicina55080403 10.1016/S0140-6736(11)61516-X 10.1097/WNF.0b013e31823429a7 10.4061/2011/306367 10.1097/01.jcp.0000169037.17884.79 10.1055/s-2000-7973 10.1016/j.psyneuen.2003.08.004 10.1176/appi.ajp.159.1.116 10.2147/NDT.S196661 10.1016/j.genhosppsych.2004.10.002 10.1097/YCO.0b013e3283387b50 10.5152/npa.2017.12457 10.1007/BF03346311 10.1017/S1121189X00004322 10.1016/j.jpsychires.2018.09.014 10.1016/0165-1781(94)90047-7 10.1016/S0893-133X(97)00181-4 10.1001/archpsyc.1982.04290030045008 10.1001/archpsyc.1990.01810170027005 10.1016/S0193-953X(05)70285-9 10.1016/S0006-3223(98)80003-6
BMC Endocrine Disorders; Zhao S, Zhang X et. al.

Oct 23rd, 2021 - Previous studies have shown that bipolar disorder is closely related to thyroid dysfunction. Psychiatric drugs have a large or small effect on thyroid function, and thyroid hormone levels can also affect the effect of drug treatment. Therefore, the purpose of this study is assessment the thyroid function of drug-naive bipolar disorder across different mood states, with the expectation of provid...

Atrial fibrillation following transcatheter atrial septal defect closure: a systematic ...
https://doi.org/10.1136/heartjnl-2021-319794
Heart (British Cardiac Society); Himelfarb JD, Shulman H et. al.

Oct 23rd, 2021 - The ostium secundum atrial septal defect (ASD) is among the most common congenital cardiac anomalies diagnosed in adulthood. A known complication of transcatheter ASD closure is the development of new-onset atrial fibrillation and flutter (AFi/AFl). These arrhythmias confer an increased risk of postoperative stroke, thrombus formation and systemic emboli. This systematic review examines the bur...

Mortality trends in pulmonary arterial hypertension in canada: a temporal analysis of s...
https://doi.org/10.1183/13993003.01552-2021
The European Respiratory Journal; Zelt JGE, Sugarman J et. al.

Oct 23rd, 2021 - The evolution in pulmonary arterial hypertension (PAH) management has been summarized in three iterations of the European Society of Cardiology/European Respiratory Society (ESC/ERS) guidelines. No study has assessed whether changes in management, as reflected in the changing guidelines, has translated to improved long-term survival in PAH. Mixed retrospective/prospective analysis of treatment ...

Long-term Outcomes of Adult Pulmonary Langerhans Cell Histiocytosis: A Prospective Cohort.
https://doi.org/10.1183/13993003.01017-2021
The European Respiratory Journal; Benattia A, Bugnet E et. al.

Oct 23rd, 2021 - The long-term outcomes of adult pulmonary Langerhans cell histiocytosis (PLCH), particularly survival, are largely unknown. Two earlier retrospective studies reported a high rate of mortality, which contrasts with our clinical experience. To address this issue, all newly diagnosed PLCH patients referred to the French national reference centre for histiocytoses between 2004 and 2018 were eligibl...

Temporal trends in pulmonary arterial hypertension: Results from the COMPERA registry.
https://doi.org/10.1183/13993003.02024-2021
The European Respiratory Journal; Hoeper MM, Pausch C et. al.

Oct 23rd, 2021 - Since 2015, the European pulmonary hypertension guidelines recommend the use of combination therapy in most patients with pulmonary arterial hypertension (PAH). However, it is unclear to what extend this treatment strategy is adopted in clinical practice and if it is associated with improved long-term survival. We analysed data from COMPERA, a large European pulmonary hypertension registry, to ...