×
About 163,924 results

Anti-PCSK9 monotherapy for hypercholesterolemia: the MENDEL-2 randomized, controlled ph...
https://doi.org/10.1016/j.jacc.2014.03.018
Journal of the American College of Cardiology; Koren MJ, Lundqvist P et. al.

Apr 2nd, 2014 - The aim of this study was to compare biweekly and monthly evolocumab with placebo and oral ezetimibe in patients with hypercholesterolemia in a phase III trial. Evolocumab, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9 (PCSK9), significantly reduced LDL-C in phase II trials. Patients 18 to 80 years of age with fasting low-density lipoprotein cholesterol...

Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance:...
https://doi.org/10.1016/j.jacc.2014.03.019
Journal of the American College of Cardiology; Stroes E, Colquhoun D et. al.

Apr 3rd, 2014 - This study sought to evaluate the efficacy and safety of subcutaneous evolocumab compared with oral ezetimibe in hypercholesterolemic patients who are unable to tolerate effective statin doses. Statin intolerance, which is predominantly due to muscle-related side effects, is reported in up to 10% to 20% of patients. Evolocumab, a fully human monoclonal antibody to proprotein convertase subtilis...

Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323184
Nature Deuse T, Hua X et. al.

Apr 21st, 2014 - Despite the introduction of antiproliferative drug-eluting stents, coronary heart disease remains the leading cause of death in the United States. In-stent restenosis and bypass graft failure are characterized by excessive smooth muscle cell (SMC) proliferation and concomitant myointima formation with luminal obliteration. Here we show that during the development of myointimal hyperplasia in hu...

EPHA2 is a mediator of vemurafenib resistance and a novel therapeutic target in melanoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355085
Cancer Discovery; Miao B, Ji Z et. al.

Dec 29th, 2014 - BRAF(V600E) is the most common oncogenic lesion in melanoma and results in constitutive activation of the MAPK pathway and uncontrolled cell growth. Selective BRAF inhibitors such as vemurafenib have been shown to neutralize oncogenic signaling, restrain cellular growth, and improve patient outcome. Although several mechanisms of vemurafenib resistance have been described, directed solutions to...

Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patient...
https://doi.org/10.1097/CCM.0000000000002380
Critical Care Medicine; Shankar-Hari M, Fear D et. al.

Mar 15th, 2017 - Sepsis is life-threatening organ dysfunction due to dysregulated host responses to infection. Current knowledge of human B-cell alterations in sepsis is sparse. We tested the hypothesis that B-cell loss in sepsis involves distinct subpopulations of B cells and investigated mechanisms of B-cell depletion. Prospective cohort study. Critical care units. Adult sepsis patients without any documented...

Combined treatment with L-carnitine and a pan-caspase inhibitor effectively reverses am...
https://doi.org/10.1007/s10495-008-0186-9
Apoptosis : an International Journal on Programmed Cell D... Yano T, Itoh Y et. al.

Feb 29th, 2008 - Amiodarone is an effective class III antiarrhythmic drug, however, the pulmonary toxicity is one of the most life-threatening complications of its use. The present study was designed to determine the mechanisms underlying pulmonary toxicity of amiodarone. In cultured human lung epithelial cells A549, amiodarone caused cell injury characterized by mitochondrial membrane depolarization, ATP deple...

Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573015
Journal of the American Society of Nephrology : JASN; Harvey SJ, Jarad G et. al.

Sep 8th, 2008 - MicroRNAs (miRNAs) regulate gene expression by binding the 3' untranslated region of mRNAs. To define their role in glomerular function, miRNA biogenesis was disrupted in mouse podocytes using a conditional Dicer allele. Mutant mice developed proteinuria by 3 wk after birth and progressed rapidly to end-stage kidney disease. Podocyte pathology included effacement, vacuolization, and hypertrophy...

Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lympho...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752081
The Journal of Clinical Investigation; Snow AL, Marsh RA et. al.

Sep 17th, 2009 - X-linked lymphoproliferative disease (XLP) is a rare congenital immunodeficiency that leads to an extreme, usually fatal increase in the number of lymphocytes upon infection with EBV. It is most commonly defined molecularly by loss of expression of SLAM-associated protein (SAP). Despite this, there is little understanding of how SAP deficiency causes lymphocytosis following EBV infection. Here ...

Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lym...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973325
Nature Compagno M, Lim WK et. al.

May 4th, 2009 - Diffuse large B-cell lymphoma (DLBCL), the most common form of lymphoma in adulthood, comprises multiple biologically and clinically distinct subtypes including germinal centre B-cell-like (GCB) and activated B-cell-like (ABC) DLBCL. Gene expression profile studies have shown that its most aggressive subtype, ABC-DLBCL, is associated with constitutive activation of the NF-kappaB transcription c...

Erythropoietin activates cell survival pathways in breast cancer stem-like cells to pro...
https://doi.org/10.1158/0008-5472.CAN-13-0248
Cancer Research; Todaro M, Turdo A et. al.

Sep 6th, 2013 - Recombinant erythropoietin (EPO) analogs [erythropoiesis-stimulating agents (ESA)] are clinically used to treat anemia in patients with cancer receiving chemotherapy. After clinical trials reporting increased adverse events and/or reduced survival in ESA-treated patients, concerns have been raised about the potential role of ESAs in promoting tumor progression, possibly through tumor cell stimu...

Reactivity to the p305 Epitope of the α1G T-Type Calcium Channel and Autoimmune-Associa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599413
Journal of the American Heart Association; Markham AJ, Rasmussen SE et. al.

May 22nd, 2015 - Only 2% of mothers positive for anti-SSA/Ro (Ro) antibodies have children with congenital heart block (CHB). This study aimed to determine whether reactivity with p305, an epitope within the α1G T-type calcium channel, confers added risk over anti-Ro antibodies. Using sera from anti-Ro-exposed pregnancies resulting in offspring with CHB, no disease but CHB-sibling, and no disease and no CHB-sib...

Antiinflammatory effects of apoptotic cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696541
The Journal of Clinical Investigation; Henson PM, Bratton DL

Jul 18th, 2013 - Apoptotic cells are rapidly phagocytosed by macrophages, a process that represents a critical step in tissue remodeling, immune responses, and the resolution of inflammation. In 1998, Peter Henson, Donna Bratton, and colleagues at National Jewish Health demonstrated that phagocytosis of apoptotic cells actively suppresses inflammation by inhibiting the production of inflammatory cytokines and i...

Clinical features of and effects of angiotensin system antagonists on amiodarone-induce...
https://doi.org/10.1016/j.ijcard.2008.11.106
International Journal of Cardiology; Nikaido A, Tada T et. al.

Dec 24th, 2008 - Amiodarone (AMD) is a strong antiarrhythmic drug but has severe side effects such as pulmonary toxicity. There are no indicators or drugs that can prevent the development of amiodarone-induced pulmonary toxicity (AIPT). We collected data for 96 consecutive patients treated with AMD and analyzed clinical factors related to AIPT. In addition, we examined the effect of AMD and angiotensin II (Ang ...

Regulatory polymorphisms in β-tubulin IIa are associated with paclitaxel-induced periph...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664665
Clinical Cancer Research : an Official Journal of the Ame... Leandro-García LJ, Leskelä S et. al.

Jun 21st, 2012 - Peripheral neuropathy is the dose-limiting toxicity of paclitaxel, a chemotherapeutic drug widely used to treat several solid tumors such as breast, lung, and ovary. The cytotoxic effect of paclitaxel is mediated through β-tubulin binding in the cellular microtubules. In this study, we investigated the association between paclitaxel neurotoxicity risk and regulatory genetic variants in β-tubuli...

Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in exp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436042
World Journal of Gastroenterology; Pacheco RG, Esposito CC et. al.

Sep 12th, 2012 - To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis. Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine, butyrate, or saline. Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure. Follow-up colo...

Nonalcoholic fatty liver disease: pathologic patterns and biopsy evaluation in clinical...
https://doi.org/10.1055/s-0032-1306421
Seminars in Liver Disease; Kleiner DE, Brunt EM

Mar 15th, 2012 - Nonalcoholic fatty liver disease (NAFLD) results in histologically complex specific and nonspecific injury patterns. In clinical research of NAFLD, the liver biopsy evaluation provides a wealth of information on the architectural arrangement and severity of a variety of histologic changes, including steatosis, inflammation, cellular injury, and fibrosis. This information is summarized as an ove...

Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917269
Circulation Wang G, Hamid T et. al.

Apr 20th, 2010 - Heme oxygenase-1 (HO-1) is an inducible stress-response protein that imparts antioxidant and antiapoptotic effects. However, its pathophysiological role in cardiac remodeling and chronic heart failure (HF) is unknown. We hypothesized that induction of HO-1 in HF alleviates pathological remodeling. Adult male nontransgenic and myocyte-restricted HO-1 transgenic mice underwent either sham operati...

Neutral antibodies to the TSH receptor are present in Graves' disease and regulate sele...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954721
Endocrinology Morshed SA, Ando T et. al.

Sep 16th, 2010 - TSH receptor (TSHR) antibodies (Abs) may be stimulating, blocking, or neutral in their functional influences and are found in patients with autoimmune thyroid disease, especially Graves' disease (GD). Stimulators are known to activate the thyroid epithelial cells via both Gs- and Gq-coupled signaling pathways, whereas blockers inhibit the action of TSH and may act as weak agonists. However, TSH...

Synergistic growth inhibition of squamous cell carcinoma of the head and neck by erloti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744235
Cancer Prevention Research (Philadelphia, Pa.); Amin AR, Khuri FR et. al.

May 27th, 2009 - We have previously reported that the green tea polyphenol epigallocatechin-3-gallate (EGCG) and the epidermal growth factor receptor-tyrosine kinase inhibitor erlotinib had synergistic growth-inhibitory effects in cell culture and a nude mouse xenograft model of squamous cell carcinoma of the head and neck. However, the mechanism of their antitumor synergism is not fully understood. In the curr...

Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293335
The Journal of Clinical Investigation; Ichimura T, Asseldonk EJ et. al.

Apr 16th, 2008 - Following injury, the clearance of apoptotic and necrotic cells is necessary for mitigation and resolution of inflammation and tissue repair. In addition to macrophages, which are traditionally assigned to this task, neighboring epithelial cells in the affected tissue are postulated to contribute to this process. Kidney injury molecule-1 (KIM-1 or TIM-1) is an immunoglobulin superfamily cell-su...