May 31st, 2020
May 31st, 2020
Health care professionals and essential workers are showing up on the frontlines during the coronavirus pandemic—risking their health every day to help other people. They need fast, free crisis counseling at their fingertips, 24/7. Crisis Text Line, Shout, and Kids Help Phone are here for the frontlines. Text FRONTLINE for support to dealing with anxiety, stress, fear, isolation, or other d...
Health care workers across the country are facing unprecedented challenges as they work to contain COVID-19. I'm Stephanie Zerwas, a psychologist in private practice at Flourish Chapel Hill as well as an Associate Professor at UNC Psychiatry. In cooperation with Eleos Health, we aim to provide pro-bono therapy for front line health care professionals.
1 (888) 409-0141 Helping our colleagues all over the U.S. on the front lines of COVID-19 Free & Confidential | No appointment necessary
We predict and analyze the drying time of respiratory droplets from a COVID-19 infected subject, which is a crucial time to infect another subject. Drying of the droplet is predicted by using a diffusion-limited evaporation model for a sessile droplet placed on a partially wetted surface with a pinned contact line. The variation in droplet volume, contact angle, ambient temperature, and humidit...
Jun 23rd, 2020 - For patients with stage IV metastatic breast cancer and an intact primary tumor (ITP), the early initiation of locoregional treatment (LRT) was not associated with longer survival or improvements in health-related quality of life (HRQoL) compared with systemic therapy alone, according to a phase III clinical trial (Abstract LBA2). These findings appear to add to a robust evidence base that sugg...
Jun 23rd, 2020 - The report on ADAURA during the ASCO20 Virtual Scientific Program Plenary Session surprised many, first because the initial data readout for the phase III trial was not planned until 2022 and second because of the strength of the disclosed data (Abstract LBA5). Early unblinding of the results revealed an 83% reduction in the risk of disease recurrence or death with use of adjuvant osimertinib c...
Jun 23rd, 2020 - Long-awaited results from the randomized, phase III KEYNOTE-177 trial provide strong support for using single-agent pembrolizumab instead of a chemotherapy-based regimen in patients newly diagnosed with metastatic colorectal cancer (mCRC) featuring high-level microsatellite instability (MSI-H) or deficient mismatch repair (dMMR; Abstract LBA4).
Jul 9th, 2020 - Tumor mutational burden is considered a hallmark indicator of a tumor’s potential for response to immunotherapy. PD-1 checkpoint inhibitors such as pembrolizumab (Keytruda, Merck) and nivolumab (Opdivo, Bristol-Myers Squibb) have been shown to be more effective in treating tumors with high mutational burden. However, despite having only a moderate number of mutations, advanced clear cell ren...
Jul 8th, 2020 - In updated results of the pilot study, presented during the ASCO2020 Virtual Scientific Program, researchers showed that lisocabtagene maraleucel induced durable response as a second-line treatment in large B-cell non-Hodgkin lymphoma.
Sir, dentists and their assistants as front-line healthcare workers (HCW) in close contact with the upper aerodigestive tract are at especial risk of transmission of the coronavirus from patients. In early infection, viral titres of greater than 107/mL in saliva and nasal mucous can be found and thus any work within the oral cavity carries an increased risk.1 Even a few microlitres of saliva co...
In 2019, regular surveillance of 110 English-language research journals identified 254 studies that met the criteria to become POEMs (patient-oriented evidence that matters). Physician members of the Canadian Medical Association rated these POEMs for their relevance to patients in their practices. This article summarizes the clinical questions and bottom-line answers from the top 20 POEMs of 20...
May 25th, 2020 - As Thomas Powles, MD, PhD, of Queen Mary University of London, prepares to deliver his late-breaking presentation at the ASCO20 Virtual Scientific Program (LBA-1), he talks with Christopher Sweeney, MBBS, of Dana-Farber Cancer Institute, about current therapy: PD1/PDL1 inhibition in second-line treatment and as monotherapy in the first-line setting, as well as the concept of maintenance switch.
May 29th, 2020 - David R. Wise, MD, PhD, of New York University Perlmutter Cancer Center, summarizes three important studies in prostate cancer: circulating tumor cell count as a prognostic marker of PSA response and progression in metastatic castration-sensitive disease; new phenotypic subtypes; and how circulating tumor DNA dynamics associate with treatment response and radiologic progression-free survival (A...
Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases;
Green herbs and seeds of fenugreek (Trigonella foenum-graecum Linn.), rhizomes of turmeric (Curcuma longa Linn.,) and ginger (Zingiber officinale Roscoe) used as foods and spices in many Asian countries are claimed to be useful in relieving pain, inflammation, and arthritis. This review describes the scientific data evaluating these claims. Fatty acids, flavonoids, saponins, alkaloids (trigonel...
May 29th, 2020 - As reported at the ASCO20 Virtual Scientific Program by Charles M. Rudin, MD, PhD, and colleagues (Abstract 9001), the phase III KEYNOTE-604 trial has shown that first-line pembrolizumab plus etoposide/platinum significantly prolonged progression-free survival and prolonged overall survival at a near significant level vs placebo plus etoposide/platinum in patients with extensive-stage small cel...
May 27th, 2020 - Adjuvant osimertinib significantly improved disease-free survival compared with placebo in patients with stage IB to IIIA EGFR-mutated non–small cell lung cancer (NSCLC) who underwent complete resection of primary tumor and received chemotherapy if indicated. These results from the first interim analysis of the phase III ADAURA trial were reported at the ASCO20 Virtual Scientific Program and f...