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About 345,642 results

Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease.
https://doi.org/10.1182/blood-2013-12-543736
Blood Spoerl S, Mathew NR et. al.

Apr 8th, 2014 - Graft-versus-host-disease (GVHD) is a severe complication of allogeneic hematopoietic cell transplantation (allo-HCT) characterized by the production of high levels of proinflammatory cytokines. Activated Janus kinases (JAKs) are required for T-effector cell responses in different inflammatory diseases, and their blockade could potently reduce acute GVHD. We observed that inhibition of JAK1/2 s...

Sildenafil use and increased risk of incident melanoma in US men: a prospective cohort ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178948
JAMA Internal Medicine; Li WQ, Qureshi AA et. al.

Apr 8th, 2014 - The RAS/RAF/mitogen-activated protein kinase and extracellular signal-regulated kinase (ERK) kinase/ERK cascade plays a crucial role in melanoma cell proliferation and survival. Sildenafil citrate (Viagra) is a phosphodiesterase (PDE) 5A inhibitor commonly used for erectile dysfunction. Recent studies have shown that BRAF activation down-regulates PDE5A levels, and low PDE5A expression by BRAF ...

Lanreotide in metastatic enteropancreatic neuroendocrine tumors.
https://doi.org/10.1056/NEJMoa1316158
The New England Journal of Medicine; Caplin ME, Pavel M et. al.

Jul 11th, 2014 - Somatostatin analogues are commonly used to treat symptoms associated with hormone hypersecretion in neuroendocrine tumors; however, data on their antitumor effects are limited. We conducted a randomized, double-blind, placebo-controlled, multinational study of the somatostatin analogue lanreotide in patients with advanced, well-differentiated or moderately differentiated, nonfunctioning, somat...

Inhibition of the mTORC pathway in the antiphospholipid syndrome.
https://doi.org/10.1056/NEJMoa1312890
The New England Journal of Medicine; Canaud G, Bienaimé F et. al.

Jul 23rd, 2014 - Although thrombosis is considered the cardinal feature of the antiphospholipid syndrome, chronic vascular lesions are common, particularly in patients with life-threatening complications. In patients who require transplantation, vascular lesions often recur. The molecular pathways involved in the vasculopathy of the antiphospholipid syndrome are unknown, and adequate therapies are lacking. We u...

Transplantation outcomes for severe combined immunodeficiency, 2000-2009.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183064
The New England Journal of Medicine; Pai SY, Logan BR et. al.

Jul 30th, 2014 - The Primary Immune Deficiency Treatment Consortium was formed to analyze the results of hematopoietic-cell transplantation in children with severe combined immunodeficiency (SCID) and other primary immunodeficiencies. Factors associated with a good transplantation outcome need to be identified in order to design safer and more effective curative therapy, particularly for children with SCID diag...

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900
The New England Journal of Medicine; Roberts KG, Li Y et. al.

Sep 10th, 2014 - Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and ad...

British Association of Dermatologists' guidelines for the management of cutaneous warts...
https://doi.org/10.1111/bjd.13310
The British Journal of Dermatology; Sterling JC, Gibbs S et. al.

Oct 2nd, 2014 - British Association of Dermatologists' guidelines for the management of cutaneous warts 2014.|2014|Sterling JC,Gibbs S,Haque Hussain SS,Mohd Mustapa MF,Handfield-Jones SE,|therapeutic use,therapeutic use,therapeutic use,therapeutic use,drug effects,methods,methods,therapeutic use,methods,methods,therapeutic use,methods,methods,methods,therapeutic use,diagnosis,therapy,

PD-1 blockade induces responses by inhibiting adaptive immune resistance.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246418
Nature Tumeh PC, Harview CL et. al.

Nov 27th, 2014 - Therapies that target the programmed death-1 (PD-1) receptor have shown unprecedented rates of durable clinical responses in patients with various cancer types. One mechanism by which cancer tissues limit the host immune response is via upregulation of PD-1 ligand (PD-L1) and its ligation to PD-1 on antigen-specific CD8(+) T cells (termed adaptive immune resistance). Here we show that pre-exist...

Human embryonic stem cell-derived retinal pigment epithelium in patients with age-relat...
https://doi.org/10.1016/S0140-6736(14)61376-3
Lancet (London, England); Schwartz SD, Regillo CD et. al.

Dec 2nd, 2014 - Since they were first derived more than three decades ago, embryonic stem cells have been proposed as a source of replacement cells in regenerative medicine, but their plasticity and unlimited capacity for self-renewal raises concerns about their safety, including tumour formation ability, potential immune rejection, and the risk of differentiating into unwanted cell types. We report the medium...

Infantile granular parakeratosis: cytologic examination of superficial scrapings as an ...
https://doi.org/10.1111/pde.12444
Pediatric Dermatology; Akkaya AD, Oram Y et. al.

Feb 10th, 2015 - Granular parakeratosis (GP) is a benign disorder of keratinization presenting with unilateral or bilateral red to brown hyperkeratotic plaques and papules at the intertriginous areas. The first pediatric case of GP was reported in 2002, and only a few cases have been reported since. Although the exact etiology of GP is unknown, it is thought that certain environmental factors compromise the epi...

Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia.
https://doi.org/10.1056/NEJMoa1503479
The New England Journal of Medicine; Baerlocher GM, Oppliger Leibundgut E et. al.

Sep 3rd, 2015 - Imetelstat, a 13-mer oligonucleotide that is covalently modified with lipid extensions, competitively inhibits telomerase enzymatic activity. It has been shown to inhibit megakaryocytic proliferation in vitro in cells obtained from patients with essential thrombocythemia. In this phase 2 study, we investigated whether imetelstat could elicit hematologic and molecular responses in patients with ...

Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists.
https://doi.org/10.1038/nature15248
Nature Prost S, Relouzat F et. al.

Sep 3rd, 2015 - Whether cancer is maintained by a small number of stem cells or is composed of proliferating cells with approximate phenotypic equivalency is a central question in cancer biology. In the stem cell hypothesis, relapse after treatment may occur by failure to eradicate cancer stem cells. Chronic myeloid leukaemia (CML) is quintessential to this hypothesis. CML is a myeloproliferative disorder that...

Diagnosis and Management of Infantile Hemangioma.
https://doi.org/10.1542/peds.2015-2485
Pediatrics Darrow DH, Greene AK et. al.

Sep 29th, 2015 - Infantile hemangiomas (IHs) are the most common tumors of childhood. Unlike other tumors, they have the unique ability to involute after proliferation, often leading primary care providers to assume they will resolve without intervention or consequence. Unfortunately, a subset of IHs rapidly develop complications, resulting in pain, functional impairment, or permanent disfigurement. As a result...

Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323184
Nature Deuse T, Hua X et. al.

Apr 21st, 2014 - Despite the introduction of antiproliferative drug-eluting stents, coronary heart disease remains the leading cause of death in the United States. In-stent restenosis and bypass graft failure are characterized by excessive smooth muscle cell (SMC) proliferation and concomitant myointima formation with luminal obliteration. Here we show that during the development of myointimal hyperplasia in hu...

Chronic variable stress activates hematopoietic stem cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087061
Nature Medicine; Heidt T, Sager HB et. al.

Jun 23rd, 2014 - Exposure to psychosocial stress is a risk factor for many diseases, including atherosclerosis. Although incompletely understood, interaction between the psyche and the immune system provides one potential mechanism linking stress and disease inception and progression. Known cross-talk between the brain and immune system includes the hypothalamic-pituitary-adrenal axis, which centrally drives gl...

Intralymphatic cutaneous anaplastic large cell lymphoma/lymphomatoid papulosis: expandi...
https://doi.org/10.1097/PAS.0000000000000217
The American Journal of Surgical Pathology; Samols MA, Su A et. al.

May 8th, 2014 - Intravascular large B-cell lymphomas and EBV NK/T-cell lymphomas commonly follow an aggressive clinical course. We recently reported an entirely intravascular anaplastic large cell lymphoma (ALCL) in the skin with a surprisingly indolent clinical course; interestingly, this lymphoma involved the lymphatic rather than the blood vasculature. We hypothesized that intravascular skin-limited ALCL is...

Microbiota organization is a distinct feature of proximal colorectal cancers.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280621
Proceedings of the National Academy of Sciences of the Un... Dejea CM, Wick EC et. al.

Dec 9th, 2014 - Environmental factors clearly affect colorectal cancer (CRC) incidence, but the mechanisms through which these factors function are unknown. One prime candidate is an altered colonic microbiota. Here we show that the mucosal microbiota organization is a critical factor associated with a subset of CRC. We identified invasive polymicrobial bacterial biofilms (bacterial aggregates), structures pre...

Randomized Phase II Study of Ramucirumab or Icrucumab in Combination with Capecitabine ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344637
The Oncologist; Vahdat LT, Layman R et. al.

Feb 21st, 2017 - Icrucumab (ICR) and ramucirumab (RAM) bind vascular endothelial growth factor (VEGF) receptors 1 and 2 (VEGFR-1 and -2), respectively. This open-label, randomized phase II study evaluated their efficacy and safety in combination with capecitabine (CAP) in patients with previously treated unresectable, locally advanced or metastatic breast cancer. Patients were randomly assigned (1:1:1) to recei...

Breastfeeding, PAM50 tumor subtype, and breast cancer prognosis and survival.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554253
Journal of the National Cancer Institute; Kwan ML, Bernard PS et. al.

Apr 29th, 2015 - Breastfeeding is associated with decreased breast cancer risk, yet associations with prognosis and survival by tumor subtype are largely unknown. We conducted a cohort study of 1636 women from two prospective breast cancer cohorts. Intrinsic tumor subtype (luminal A, luminal B, human epidermal growth factor receptor 2 [HER2]-enriched, basal-like) was determined by the PAM50 gene expression assa...

Statin Use at the Time of Initiation of Androgen Deprivation Therapy and Time to Progre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554437
JAMA Oncology; Harshman LC, Wang X et. al.

Jul 16th, 2015 - Statin use has been associated with improved prostate cancer outcomes. Dehydroepiandrosterone sulfate (DHEAS) is a precursor of testosterone and a substrate for SLCO2B1, an organic anionic transporter. We previously demonstrated that genetic variants of SLCO2B1 correlated with time to progression (TTP) during receipt of androgen deprivation therapy (ADT). Statins also use SLCO2B1 to enter cells...