×
About 337,298 results

A case of COVID-19 pneumonia with cerebral hemorrhage
https://www.thrombosisresearch.com/article/S0049-3848(20)30232-2/fulltext

We agree with Dr. Klok that thromboprophylactic dose low molecular weight heparin should be recommended for all the critically ill patients with 2019 novel coronavirus disease (COVID-19) pneumonia [1]. The very high cumulative incidence of thrombotic complications raises the question if therapeutic anticoagulation should be considered for severe COVID-19 pneumonia patients. As previously report...

COVID-19 Planning Considerations: Guidance for School Re-entry
https://services.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/clinical-guidance/covid-19-planning-considerations-return-to-in-person-education-in-schools/

The purpose of this guidance is to support education, public health, local leadership, and pediatricians collaborating with schools in creating policies for school re-entry that foster the overall health of children, adolescents, staff, and communities and are based on available evidence. Schools are fundamental to child and adolescent development and well-being and provide our children and ado...

Patients with mental health disorders in the COVID-19 epidemic
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(20)30090-0/fulltext?fbclid=IwAR1SZKyMFNC4ngsiAq7v_JMx09wwwqPPDuaU8sgK47ryBXedW120fpHk5w8

More than 60 000 infections have been confirmed worldwide in the coronavirus disease 2019 (COVID-19) epidemic, with most of these cases in China. Global attention has largely been focused on the infected patients and the frontline responders, with some marginalised populations in society having been overlooked. Here, we write to express our concerns with regards to the effect of the epidemic on...

Imaging in Parkinson’s disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280219/
Clinical Medicine;

The clinical presentation of Parkinson’s disease (PD) is heterogeneous and overlaps with other conditions, including the parkinsonian variant of multiple system atrophy (MSA-P), progressive supranuclear palsy (PSP) and essential tremor. Imaging of the brain in patients with parkinsonism has the ability to increase the accuracy of differential diagnosis. Magnetic resonance imaging (MRI), single ...

Cognitive Function Impairments Linked to Alcohol and Cannabis Use During Adolescence: A Study of Gender Differences
https://www.frontiersin.org/articles/10.3389/fnhum.2020.00095/full?report=reader

Major neurocognitive changes occur during adolescence, making this phase one of the most critical developmental periods of life. Furthermore, this phase in life is also the time in which youth substance use begins. Several studies have demonstrated the differential associations of alcohol and cannabis use concerning the neurocognitive functioning of both males and females. Past and contemporary...

Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation
https://pubmed.ncbi.nlm.nih.gov/16888140/

Immunoglobulin G (IgG) mediates pro- and anti-inflammatory activities through the engagement of its Fc fragment (Fc) with distinct Fcg receptors (FcgRs). One class of Fc-FcgR interactions generates pro-inflammatory effects of immune complexes and cytotoxic antibodies. In contrast, therapeutic intravenous gamma globulin and its Fc fragments are anti-inflammatory. We show here that these distinct...

Differential risk of incident cancer in patients with heart failure: A nationwide population-based cohort study
https://www.journal-of-cardiology.com/article/S0914-5087(20)30271-9/fulltext
Journal of Cardiology; Kwak S

Aug 25th, 2020 - Patients with heart failure (HF) are more at risk of developing cancer than the general population.

COVID-19: Differential Diagnosis and Co-infections
https://www.un.org/sites/un2.un.org/files/coronavirus_guidancecoinfections.pdf
DHMOSH - Public Health Unit

As COVID-19 has a variety of clinical manifestations, including fever, cough, headache, myalgia, fatigue. etc., it may be challenging to distinguish the infection from other diseases with similar presentations such as malaria, especially in endemic areas. Furthermore, there is always a potential of co-infections in the same patient.

Palpitations: Causes and Differential Diagnosis of Palpitations
https://www.timeofcare.com/palpitations-differential-diagnosis/
Time of Care;

Causes of palpitations can be divided into four main categories: 1) Psychiatric, 2) cardiac, 3) Medication, and 4) Systemic medical causes.

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus.
https://doi.org/10.1056/NEJMoa1803760
The New England Journal of Medicine; Fenske W, Refardt J et. al.

Aug 1st, 2018 - The indirect water-deprivation test is the current reference standard for the diagnosis of diabetes insipidus. However, it is technically cumbersome to administer, and the results are often inaccurate. The current study compared the indirect water-deprivation test with direct detection of plasma copeptin, a precursor-derived surrogate of arginine vasopressin. From 2013 to 2017, we recruited 156...

Identification of Extremely Premature Infants at Low Risk for Early-Onset Sepsis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654397
Pediatrics Puopolo KM, Mukhopadhyay S et. al.

Oct 6th, 2017 - Premature infants are at high risk of early-onset sepsis (EOS) relative to term infants, and most are administered empirical antibiotics after birth. We aimed to determine if factors evident at birth could be used to identify premature infants at lower risk of EOS. Study infants were born at 22 to 28 weeks' gestation in Neonatal Research Network centers from 2006 to 2014. EOS was defined by iso...

Drug reaction with eosinophilia and systemic symptoms, or virus reactivation with eosin...
https://doi.org/10.1111/bjd.13079
The British Journal of Dermatology; Almudimeegh A, Rioux C et. al.

Apr 29th, 2014 - We report a case of drug reaction with eosinophilia and systemic symptoms (DRESS) in a patient with HIV receiving antitoxoplasmic drugs (adiazine and pyrimethamine) and levetiracetam along with highly active antiretroviral therapy (tenofovir-emtricitabine, darunavir and ritonavir). Cytomegalovirus (CMV) infection was reactivated in the 7 weeks before the development of DRESS but was successfull...

Accuracy of point-of-care multiorgan ultrasonography for the diagnosis of pulmonary emb...
https://doi.org/10.1378/chest.13-1087
Chest Nazerian P, Vanni S et. al.

Oct 4th, 2013 - Presenting signs and symptoms of pulmonary embolism (PE) are nonspecific, favoring a large use of second-line diagnostic tests such as multidetector CT pulmonary angiography (MCTPA), thus exposing patients to high-dose radiation and to potential serious complications. We investigated the diagnostic performance of multiorgan ultrasonography (lung, heart, and leg vein ultrasonography) and whether...

Subclinical thyroid disease.
https://doi.org/10.1016/S0140-6736(11)60276-6
Lancet (London, England); Cooper DS, Biondi B

Jan 25th, 2012 - Subclinical thyroid diseases--subclinical hyperthyroidism and subclinical hypothyroidism--are common clinical entities that encompass mild degrees of thyroid dysfunction. The clinical significance of mild thyroid overactivity and underactivity is uncertain, which has led to controversy over the appropriateness of diagnostic testing and possible treatment. In this Seminar, we discuss the definit...

Breastfeeding in children of women taking antiepileptic drugs: cognitive outcomes at ag...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122685
JAMA Pediatrics; Meador KJ, Baker GA et. al.

Jun 17th, 2014 - Breastfeeding is known to have beneficial effects, but concern exists that breastfeeding during maternal antiepileptic drug (AED) therapy may be harmful. We previously noted no adverse effects of breastfeeding associated with AED use on IQ at age 3 years, but IQ at age 6 years is more predictive of school performance and adult abilities. To examine the effects of AED exposure via breastfeeding ...

Isolated free fluid on abdominal computed tomography in blunt trauma: watch and wait or...
https://doi.org/10.1016/j.jamcollsurg.2014.04.020
Journal of the American College of Surgeons; Gonser-Hafertepen LN, Davis JW et. al.

Aug 15th, 2014 - Isolated free fluid (FF) on abdominal CT in stable blunt trauma patients can indicate the presence of hollow viscus injury. No criteria exist to differentiate treatment by operative exploration vs observation. The goals of this study were to determine the incidence of isolated FF and to identify factors that discriminate between patients who should undergo operative exploration vs observation. ...

Psychiatric comorbidity and psychosocial impairment among patients with vertigo and diz...
https://doi.org/10.1136/jnnp-2014-307601
Journal of Neurology, Neurosurgery, and Psychiatry; Lahmann C, Henningsen P et. al.

Jun 25th, 2014 - Vertigo and dizziness are often not fully explained by an organic illness, but instead are related to psychiatric disorders. This study aimed to evaluate psychiatric comorbidity and assess psychosocial impairment in a large sample of patients with a wide range of unselected organic and non-organic (ie, medically unexplained) vertigo/dizziness syndromes. This cross-sectional study involved a sam...

An inflammatory biomarker as a differential predictor of outcome of depression treatmen...
https://doi.org/10.1176/appi.ajp.2014.14010094
The American Journal of Psychiatry; Uher R, Tansey KE et. al.

Jul 15th, 2014 - Major depressive disorder has been linked with inflammatory processes, but it is unclear whether individual differences in levels of inflammatory biomarkers could help match patients to treatments that are most likely to be beneficial. The authors tested the hypothesis that C-reactive protein (CRP), a commonly available marker of systemic inflammation, predicts differential response to escitalo...

Comparative analysis of rosacea and cutaneous lupus erythematosus: histopathologic feat...
https://doi.org/10.1016/j.jaad.2014.01.892
Journal of the American Academy of Dermatology; Brown TT, Choi EY et. al.

Mar 24th, 2014 - Distinction of rosacea and cutaneous lupus erythematosus (LE) can be challenging because of significant clinical and histologic overlap. A controlled study comparing these conditions is lacking. We compared the histologic features, T-cell subsets, and plasmacytoid dendritic cells in rosacea and LE. Biopsy specimens of rosacea (n = 27) and facial LE (n = 30) were retrospectively reviewed and rea...

Two clinical phenotypes in polycythemia vera.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211877
The New England Journal of Medicine; Spivak JL, Considine M et. al.

Aug 27th, 2014 - Polycythemia vera is the ultimate phenotypic consequence of the V617F mutation in Janus kinase 2 (encoded by JAK2), but the extent to which this mutation influences the behavior of the involved CD34+ hematopoietic stem cells is unknown. We analyzed gene expression in CD34+ peripheral-blood cells from 19 patients with polycythemia vera, using oligonucleotide microarray technology after correctin...