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About 199,008 results

Association of Preoperatively Diagnosed Patent Foramen Ovale With Perioperative Ischemi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839297
JAMA Ng PY, Ng AK et. al.

Feb 7th, 2018 - Perioperative stroke is a major complication for patients undergoing surgery. Patent foramen ovale (PFO) represents a possible anatomical link between venous thrombosis and stroke. To determine whether a preoperatively diagnosed PFO is associated with increased risk of perioperative ischemic stroke. Retrospective cohort study from Massachusetts General Hospital and 2 affiliated community hospit...

Risk of post-pregnancy hypertension in women with a history of hypertensive disorders o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506851
BMJ (Clinical Research Ed.); Behrens I, Basit S et. al.

Jul 13th, 2017 - Objectives To determine how soon after delivery the risk of post-pregnancy hypertension increases in women with hypertensive disorders of pregnancy and how the risk evolves over time.Design Nationwide register based cohort study.Setting Denmark.Populations 482 972 primiparous women with a first live birth or stillbirth between 1995 and 2012 (cumulative incidence analyses), and 1 025 118 women w...

Late Relapse of Classical Hodgkin Lymphoma: An Analysis of the German Hodgkin Study Gro...
https://doi.org/10.1200/JCO.2016.71.3289
Journal of Clinical Oncology : Official Journal of the Am... Bröckelmann PJ, Goergen H et. al.

Feb 27th, 2017 - Purpose Clinical characteristics, therapeutic approaches, and prognosis of late relapse (LR) in patients with classic Hodgkin lymphoma (cHL) are poorly understood. We performed a comprehensive analysis of LR of Hodgkin lymphoma (LR-HL). Methods To estimate the incidence of LR-HL, we retrospectively analyzed 6,840 patients with cHL included in the German Hodgkin Study Group trials HD7 to HD12. P...

History of breast feeding and risk of incident endometriosis: prospective cohort study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574033
BMJ (Clinical Research Ed.); Farland LV, Eliassen AH et. al.

Aug 30th, 2017 - Objective To investigate the association between lifetime breast feeding, exclusive breast feeding, postpartum amenorrhea, and incidence of endometriosis among parous women.Design Prospective cohort study.Setting Nurses' Health Study II, 1989-2011.Participants 72 394women who reported having one or more pregnancies that lasted at least six months, 3296 of whom had laparoscopically confirmed end...

Public health impact of colonoscopy use on colorectal cancer mortality in Germany and t...
https://doi.org/10.1016/j.gie.2017.04.005
Gastrointestinal Endoscopy; Chen C, Stock C et. al.

Apr 22nd, 2017 - Colonoscopy has been demonstrated to be effective in reducing colorectal cancer (CRC) incidence and mortality and has been widely used for primary CRC screening in Germany and the United States. We performed a population-based analysis to evaluate and compare the public health impact of recent colonoscopy use on CRC deaths among adults aged 55 to 79 years in Germany and the United States from 2...

Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation.
https://doi.org/10.1056/NEJMoa1708454
The New England Journal of Medicine; Cannon CP, Bhatt DL et. al.

Aug 28th, 2017 - Triple antithrombotic therapy with warfarin plus two antiplatelet agents is the standard of care after percutaneous coronary intervention (PCI) for patients with atrial fibrillation, but this therapy is associated with a high risk of bleeding. In this multicenter trial, we randomly assigned 2725 patients with atrial fibrillation who had undergone PCI to triple therapy with warfarin plus a P2Y12...

Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.
https://doi.org/10.1056/NEJMoa1612917
The New England Journal of Medicine; Holman RR, Bethel MA et. al.

Sep 14th, 2017 - The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first oc...

Increased age and race-specific incidence of cervical cancer after correction for hyste...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073302
Cancer Rositch AF, Nowak RG et. al.

May 13th, 2014 - Invasive cervical cancer is thought to decline in women over 65 years old, the age at which cessation of routine cervical cancer screening is recommended. However, national cervical cancer incidence rates do not account for the high prevalence of hysterectomy in the United States. Using estimates of hysterectomy prevalence from the Behavioral Risk Factor Surveillance System (BRFSS), hysterectom...

Risk of cerebral arteriovenous malformation rupture during pregnancy and puerperium.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035708
Neurology Liu XJ, Wang S et. al.

Apr 24th, 2014 - To determine whether the risk of arteriovenous malformation (AVM) rupture is increased during pregnancy and puerperium. Participants included 979 female patients with intracranial AVM admitted to Beijing Tiantan Hospital between 1960 and 2010. Two neurosurgery residents reviewed medical records for each case. Of them, 393 patients with ruptured AVM between 18 and 40 years of age were used for c...

Hygiene strategies to prevent methicillin-resistant Staphylococcus aureus skin and soft...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017895
Clinical Infectious Diseases : an Official Publication Of... Ellis MW, Schlett CD et. al.

Mar 18th, 2014 - Effective measures are needed to prevent methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections (SSTIs) in high-risk community settings. The study objective was to evaluate the effect of personal hygiene-based strategies on rates of overall SSTI and MRSA SSTI. We conducted a prospective, field-based, cluster-randomized trial in US Army Infantry trainees from May 2010...

Long-term outcomes of patients with nonsurgically managed uncomplicated appendicitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151128
Journal of the American College of Surgeons; McCutcheon BA, Chang DC et. al.

Mar 25th, 2014 - Emerging literature has supported the safety of nonoperative management of uncomplicated appendicitis. Patients with emergent, uncomplicated appendicitis were identified by appropriate ICD-9 diagnosis codes in the California Office of Statewide Health Planning and Development database from 1997 to 2008. Rates of treatment failure, recurrence, and perforation after nonsurgical management were ca...

New oral anticoagulants in elderly adults: evidence from a meta-analysis of randomized ...
https://doi.org/10.1111/jgs.12799
Journal of the American Geriatrics Society; Sardar P, Chatterjee S et. al.

May 2nd, 2014 - To evaluate the efficacy and safety of new oral anticoagulants (NOACs) in elderly adults. Meta-analyses of randomized clinical trials (RCTs). PubMed, Cochrane Library, EMBASE, Web of Science, and CINAHL databases were searched from January 1, 2001, through March 30, 2013. Elderly population (≥ 75) in RCTs comparing NOACs (rivaroxaban, apixaban, and dabigatran) with conventional therapy. Two aut...

Incidence of clinically important biphasic reactions in emergency department patients w...
https://doi.org/10.1016/j.annemergmed.2013.10.017
Annals of Emergency Medicine; Grunau BE, Li J et. al.

Nov 18th, 2013 - Allergic reactions are common presentations to the emergency department (ED). An unknown proportion of patients will develop biphasic reactions, and patients are often monitored for prolonged periods to manage potential reactions. We seek to determine the incidence of clinically important biphasic reactions. Consecutive adult patients presenting to 2 urban EDs with allergic reactions during a 5...

A genetic basis for infectious mononucleosis: evidence from a family study of hospitali...
https://doi.org/10.1093/cid/ciu204
Clinical Infectious Diseases : an Official Publication Of... Rostgaard K, Wohlfahrt J et. al.

Apr 3rd, 2014 - Circumstantial evidence from genome-wide association and family studies of various Epstein-Barr virus-associated diseases suggests a substantial genetic component in infectious mononucleosis (IM) etiology. However, familial aggregation of IM has scarcely been studied. We used data from the Danish Civil Registration System and the Danish National Hospital Discharge Register to study rate ratios ...

Syphilis predicts HIV incidence among men and transgender women who have sex with men i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166980
Clinical Infectious Diseases : an Official Publication Of... Solomon MM, Mayer KH et. al.

Jun 14th, 2014 - Syphilis infection may potentiate transmission of human immunodeficiency virus (HIV). We sought to determine the extent to which HIV acquisition was associated with syphilis infection within an HIV preexposure prophylaxis (PrEP) trial and whether emtricitabine/tenofovir (FTC/TDF) modified that association. The Preexposure Prophylaxis Initiative (iPrEx) study randomly assigned 2499 HIV-seronegat...

Drug treatment for attention-deficit/hyperactivity disorder and suicidal behaviour: reg...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062356
BMJ (Clinical Research Ed.); Chen Q, Sjölander A et. al.

Jun 19th, 2014 - To investigate the association between drug treatment for attention-deficit/hyperactivity disorder (ADHD) and risk of concomitant suicidal behaviour among patients with ADHD. Register based longitudinal study using within patient design. Linkage of multiple national registers in Sweden. 37,936 patients with ADHD born between 1960 and 1996 and followed from 2006 to 2009 for treatment status by A...

Daily oral tenofovir and emtricitabine-tenofovir preexposure prophylaxis reduces herpes...
https://doi.org/10.7326/M13-2471
Annals of Internal Medicine; Celum C, Morrow RA et. al.

Jun 30th, 2014 - Daily oral preexposure prophylaxis (PrEP) using the antiretroviral tenofovir disoproxil fumarate (TDF) alone or in combination with emtricitabine (FTC-TDF) reduces the risk for HIV-1 acquisition. Tenofovir has in vitro activity against herpes simplex virus type 2 (HSV-2). To assess the efficacy of daily oral PrEP with tenofovir and FTC-TDF in the prevention of HSV-2 acquisition. Subgroup analys...

Five-year outcomes in patients with left main disease treated with either percutaneous ...
https://doi.org/10.1161/CIRCULATIONAHA.113.006689
Circulation Morice MC, Serruys PW et. al.

Apr 4th, 2014 - Current guidelines recommend coronary artery bypass graft surgery (CABG) when treating significant de novo left main coronary artery (LM) stenosis; however, percutaneous coronary intervention (PCI) has a class IIa indication for unprotected LM disease in selected patients. This analysis compares 5-year clinical outcomes in PCI- and CABG-treated LM patients in the Synergy Between PCI With Taxus ...

Preoperative β-blocker use in coronary artery bypass grafting surgery: national databas...
https://doi.org/10.1001/jamainternmed.2014.2356
JAMA Internal Medicine; Brinkman W, Herbert MA et. al.

Jun 17th, 2014 - Use of preoperative β-blockers has been associated with a reduction in perioperative mortality for patients undergoing coronary artery bypass grafting (CABG) surgery in observational research studies, which led to the adoption of preoperative β-blocker therapy as a national quality standard. To determine whether preoperative β-blocker use within 24 hours of CABG surgery is associated with reduc...

Timely versus delayed early childhood vaccination and seizures.
https://doi.org/10.1542/peds.2013-3429
Pediatrics Hambidge SJ, Newcomer SR et. al.

May 20th, 2014 - Little is known regarding the timing of childhood vaccination and postvaccination seizures. In a cohort of 323 247 US children from the Vaccine Safety Datalink born from 2004 to 2008, we analyzed the association between the timing of childhood vaccination and the first occurrence of seizure with a self-controlled case series analysis of the first doses of individual vaccines received in the fir...