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About 181,040 results

Comorbidity in multiple sclerosis is associated with diagnostic delays and increased mo...
https://doi.org/10.1212/WNL.0000000000004508
Neurology Thormann A, Sørensen PS et. al.

Sep 21st, 2017 - To investigate the effect of chronic comorbidity on the time of diagnosis of multiple sclerosis (MS) and on mortality in MS. We conducted a population-based, nationwide cohort study including all incident MS cases in Denmark with first MS symptom between 1980 and 2005. To investigate the time of diagnosis, we compared individuals with and without chronic comorbidity using multinomial logistic r...

Vitamin, mineral, and multivitamin supplements for the primary prevention of cardiovasc...
https://doi.org/10.7326/M14-0198
Annals of Internal Medicine; Moyer VA,

Feb 25th, 2014 - Update of the 2003 U.S. Preventive Services Task Force (USPSTF) recommendation on vitamin supplementation to prevent cardiovascular disease and cancer. The USPSTF reviewed the evidence on the efficacy of multivitamin or mineral supplements in the general adult population for the prevention of cardiovascular disease and cancer. This recommendation applies to healthy adults without special nutrit...

Vitamin D and mortality: meta-analysis of individual participant data from a large cons...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061380
BMJ (Clinical Research Ed.); Schöttker B, Jorde R et. al.

Jun 18th, 2014 - To investigate the association between serum 25-hydroxyvitamin D concentrations (25(OH)D) and mortality in a large consortium of cohort studies paying particular attention to potential age, sex, season, and country differences. Meta-analysis of individual participant data of eight prospective cohort studies from Europe and the US. General population. 26,018 men and women aged 50-79 years. All-c...

The effect of low molecular weight heparin on survival in cancer patients: an updated s...
https://doi.org/10.1111/jth.12595
Journal of Thrombosis and Haemostasis : JTH; Sanford D, Naidu A et. al.

May 6th, 2014 - Tumors may exploit the coagulation system to enhance the survival and dissemination of cancer cells. Some studies have suggested that heparin and low molecular weight heparin (LMWH) have antitumor effects. We reported a previous meta-analysis that suggested a modest improvement in overall survival with the use of LMWH in patients with cancer. Herein, we present the results of an updated systema...

Cancer screening rates in individuals with different life expectancies.
https://doi.org/10.1001/jamainternmed.2014.3895
JAMA Internal Medicine; Royce TJ, Hendrix LH et. al.

Aug 18th, 2014 - Routine cancer screening has unproven net benefit for patients with limited life expectancy. To examine the patterns of prostate, breast, cervical, and colorectal cancer screening in the United States in individuals with different life expectancies. Data from the population-based National Health Interview Survey (NHIS) from 2000 through 2010 were used and included 27 404 participants aged 65 ye...

Vaccination against zoster remains effective in older adults who later undergo chemothe...
https://doi.org/10.1093/cid/ciu498
Clinical Infectious Diseases : an Official Publication Of... Tseng HF, Tartof S et. al.

Aug 6th, 2014 - Approximately 40% of adults develop invasive cancer during their lifetimes, many of whom require chemotherapy. Herpes zoster (HZ) is common and often severe in patients undergoing chemotherapy, yet there are no data regarding whether these patients retain specific protection against HZ if they had previously received zoster vaccine. We conducted a study to determine whether zoster vaccine was e...

Comparative effectiveness of pharmacologic treatments to prevent fractures: an updated ...
https://doi.org/10.7326/M14-0317
Annals of Internal Medicine; Crandall CJ, Newberry SJ et. al.

Sep 9th, 2014 - Osteoporosis is a major contributor to the propensity to fracture among older adults, and various pharmaceuticals are available to treat it. To update a review about the benefits and harms of pharmacologic treatments used to prevent fractures in adults at risk. Multiple computerized databases were searched between 2 January 2005 and 4 March 2014 for English-language studies. Trials, observation...

Effects of early versus delayed initiation of antiretroviral treatment on clinical outc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144040
The Lancet. Infectious Diseases; Grinsztejn B, Hosseinipour MC et. al.

Mar 7th, 2014 - Use of antiretroviral treatment for HIV-1 infection has decreased AIDS-related morbidity and mortality and prevents sexual transmission of HIV-1. However, the best time to initiate antiretroviral treatment to reduce progression of HIV-1 infection or non-AIDS clinical events is unknown. We reported previously that early antiretroviral treatment reduced HIV-1 transmission by 96%. We aimed to comp...

Direct oral anticoagulants in patients with VTE and cancer: a systematic review and met...
https://doi.org/10.1378/chest.14-0402
Chest Vedovati MC, Germini F et. al.

Sep 11th, 2014 - Direct oral anticoagulants (DOAs) have been shown to be as effective and at least as safe as conventional anticoagulation for the prevention of recurrences in patients with VTE. Whether this is the case in patients with cancer-associated VTE remains undefined. We performed a meta-analysis of randomized controlled trials with the aim of assessing the efficacy and safety of DOAs in patients with ...

Incidence of Pneumocystis jiroveci pneumonia among groups at risk in HIV-negative patie...
https://doi.org/10.1016/j.amjmed.2014.07.010
The American Journal of Medicine; Fillatre P, Decaux O et. al.

Jul 24th, 2014 - Pneumocystis jiroveci pneumonia in human immunodeficiency virus (HIV)-negative immunocompromised patients is associated with high mortality rates. Although trimethoprim-sulfamethoxazole provides a very effective prophylaxis, pneumocystosis still occurs and may even be emerging due to suboptimal characterization of patients most at risk, hence precluding targeted prophylaxis. We retrospectively ...

Association Between Malignancy and Topical Use of Pimecrolimus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465068
JAMA Dermatology; Margolis DJ, Abuabara K et. al.

Feb 18th, 2015 - A black box warning describes a potential risk of malignancy associated with topical use of pimecrolimus to treat atopic dermatitis due to its similarity to oral calcineurin inhibitors used in solid-organ transplantation and spontaneous reporting of malignancies, including lymphomas and cutaneous malignancies. To evaluate the risk of malignancy in a postmarketing study of children exposed to pi...

Association of Bullous Pemphigoid and Malignant Neoplasms.
https://doi.org/10.1001/jamadermatol.2014.5263
JAMA Dermatology; Cai SC, Allen JC et. al.

Feb 11th, 2015 - Association of Bullous Pemphigoid and Malignant Neoplasms.|2015|Cai SC,Allen JC,Lim YL,Tan SH,Tang MB,|epidemiology,pathology,epidemiology,pathology,

Warfarin-induced venous limb ischemia/gangrene complicating cancer: a novel and clinica...
https://doi.org/10.1182/blood-2015-01-622787
Blood Warkentin TE, Cook RJ et. al.

May 16th, 2015 - Venous limb gangrene (VLG) can occur in cancer patients, but the clinical picture and pathogenesis remain uncertain. We identified 10 patients with metastatic cancer (7 pathologically proven) who developed severe venous limb ischemia (phlegmasia/VLG) after initiating treatment of deep-vein thrombosis (DVT); in 8 patients, cancer was not known or suspected at presentation. The patients exhibited...

Noninvasive Prenatal Testing and Incidental Detection of Occult Maternal Malignancies.
https://doi.org/10.1001/jama.2015.7120
JAMA Bianchi DW, Chudova D et. al.

Jul 14th, 2015 - Understanding the relationship between aneuploidy detection on noninvasive prenatal testing (NIPT) and occult maternal malignancies may explain results that are discordant with the fetal karyotype and improve maternal clinical care. To evaluate massively parallel sequencing data for patterns of copy-number variations that might prospectively identify occult maternal malignancies. Case series id...

Tinzaparin vs Warfarin for Treatment of Acute Venous Thromboembolism in Patients With A...
https://doi.org/10.1001/jama.2015.9243
JAMA Lee AYY, Kamphuisen PW et. al.

Aug 18th, 2015 - Low-molecular-weight heparin is recommended over warfarin for the treatment of acute venous thromboembolism (VTE) in patients with active cancer largely based on results of a single, large trial. To study the efficacy and safety of tinzaparin vs warfarin for treatment of acute, symptomatic VTE in patients with active cancer. A randomized, open-label study with blinded central adjudication of st...

Light to moderate intake of alcohol, drinking patterns, and risk of cancer: results fro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540790
BMJ (Clinical Research Ed.); Cao Y, Willett WC et. al.

Aug 19th, 2015 - To quantify risk of overall cancer across all levels of alcohol consumption among women and men separately, with a focus on light to moderate drinking and never smokers; and assess the influence of drinking patterns on overall cancer risk. Two prospective cohort studies. Health professionals in the United States. 88,084 women and 47,881 men participating in the Nurses' Health Study (from 1980) ...

Prospective Cohort Study of Hospital Palliative Care Teams for Inpatients With Advanced...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550689
Journal of Clinical Oncology : Official Journal of the Am... May P, Garrido MM et. al.

Jun 9th, 2015 - Previous studies report that early palliative care is associated with clinical benefits, but there is limited evidence on economic impact. This article addresses the research question: Does timing of palliative care have an impact on its effect on cost? Using a prospective, observational design, clinical and cost data were collected for adult patients with an advanced cancer diagnosis admitted ...

Long-Term Health Outcomes in Women With Silicone Gel Breast Implants: A Systematic Review.
https://doi.org/10.7326/M15-1169
Annals of Internal Medicine; Balk EM, Earley A et. al.

Nov 9th, 2015 - Silicone gel breast implants were removed from the U.S. market for cosmetic use in 1992 owing to safety concerns. They were reintroduced in 2006, with a call for improved surveillance of clinical outcomes. To systematically review the literature regarding specific long-term health outcomes in women with silicone gel breast implants, including cancer; connective tissue, rheumatologic, and autoim...

Community-acquired bacterial meningitis in adults with cancer or a history of cancer.
https://doi.org/10.1212/WNL.0000000000002315
Neurology Costerus JM, Brouwer MC et. al.

Jan 23rd, 2016 - To study the incidence, clinical presentation, causative bacteria, and outcome of community-acquired bacterial meningitis in adults with cancer. We evaluated incidence and characteristics of patients with cancer included in a nationwide prospective cohort study of adults with community-acquired meningitis performed in the Netherlands from March 1, 2006, to September 31, 2014. All patients under...

Cardiac Outcomes in Adult Survivors of Childhood Cancer Exposed to Cardiotoxic Therapy:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809016
Annals of Internal Medicine; Mulrooney DA, Armstrong GT et. al.

Jan 9th, 2016 - Studies of cardiac disease among adult survivors of childhood cancer have generally relied on self-reported or registry-based data. To systematically assess cardiac outcomes among survivors of childhood cancer. Cross-sectional study. St. Jude Children's Research Hospital. 1853 adult survivors of childhood cancer, aged 18 years or older, who received cancer-related cardiotoxic therapy at least 1...