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About 345,090 results

Cystic Fibrosis Colorectal Cancer Screening Consensus Recommendations.
https://doi.org/10.1053/j.gastro.2017.12.012
Gastroenterology Hadjiliadis D, Khoruts A et. al.

Dec 31st, 2017 - Improved therapy has substantially increased survival of persons with cystic fibrosis (CF). But the risk of colorectal cancer (CRC) in adults with CF is 5-10 times greater compared to the general population, and 25-30 times greater in CF patients after an organ transplantation. To address this risk, the CF Foundation convened a multi-stakeholder task force to develop CRC screening recommendatio...

Consensus Recommendations for Evaluation, Interpretation, and Utilization of Computed T...
https://doi.org/10.1053/j.gastro.2017.11.274
Gastroenterology Bruining DH, Zimmermann EM et. al.

Jan 13th, 2018 - Computed tomography and magnetic resonance enterography have become routine small bowel imaging tests to evaluate patients with established or suspected Crohn's disease, but the interpretation and use of these imaging modalities can vary widely. A shared understanding of imaging findings, nomenclature, and utilization will improve the utility of these imaging techniques to guide treatment optio...

Melanoma patients with an unknown primary tumor site have a better outcome than those w...
https://doi.org/10.1245/s10434-014-3679-5
Annals of Surgical Oncology; van der Ploeg AP, Haydu LE et. al.

May 7th, 2014 - Several reports in the literature suggest a difference in outcome between melanoma patients with macroscopic (clinically palpable) nodal disease from an unknown primary (MUP) and a known primary (MKP). The purpose of this study was to compare the outcomes for MUP and MKP patients after therapeutic lymph node dissection (TLND) for macroscopic nodal disease. From a large, prospective, single-inst...

Effect of smoke-free legislation on perinatal and child health: a systematic review and...
https://doi.org/10.1016/S0140-6736(14)60082-9
Lancet (London, England); Been JV, Nurmatov UB et. al.

Mar 31st, 2014 - Smoke-free legislation has the potential to reduce the substantive disease burden associated with second-hand smoke exposure, particularly in children. We investigated the effect of smoke-free legislation on perinatal and child health. We searched 14 online databases from January, 1975 to May, 2013, with no language restrictions, for published studies, and the WHO International Clinical Trials ...

New oral anticoagulants in elderly adults: evidence from a meta-analysis of randomized ...
https://doi.org/10.1111/jgs.12799
Journal of the American Geriatrics Society; Sardar P, Chatterjee S et. al.

May 2nd, 2014 - To evaluate the efficacy and safety of new oral anticoagulants (NOACs) in elderly adults. Meta-analyses of randomized clinical trials (RCTs). PubMed, Cochrane Library, EMBASE, Web of Science, and CINAHL databases were searched from January 1, 2001, through March 30, 2013. Elderly population (≥ 75) in RCTs comparing NOACs (rivaroxaban, apixaban, and dabigatran) with conventional therapy. Two aut...

Accuracy of point-of-care multiorgan ultrasonography for the diagnosis of pulmonary emb...
https://doi.org/10.1378/chest.13-1087
Chest Nazerian P, Vanni S et. al.

Oct 4th, 2013 - Presenting signs and symptoms of pulmonary embolism (PE) are nonspecific, favoring a large use of second-line diagnostic tests such as multidetector CT pulmonary angiography (MCTPA), thus exposing patients to high-dose radiation and to potential serious complications. We investigated the diagnostic performance of multiorgan ultrasonography (lung, heart, and leg vein ultrasonography) and whether...

Maternal behaviors promoting language acquisition in slow-to-talk toddlers: prospective...
https://doi.org/10.1097/DBP.0000000000000056
Journal of Developmental and Behavioral Pediatrics : JDBP; Levickis P, Reilly S et. al.

Apr 21st, 2014 - To determine, in a community-based sample of slow-to-talk toddlers, the extent to which specific maternal responsive behaviors at 24 months predict child language at 24 and 36 months. Mother-child dyads were recruited for this prospective longitudinal study from 3 local government areas spanning low, middle, and high socioeconomic status in Melbourne, Australia. At child age 18 months, 1138 par...

Superiority of frailty over age in predicting outcomes among geriatric trauma patients:...
https://doi.org/10.1001/jamasurg.2014.296
JAMA Surgery; Joseph B, Pandit V et. al.

Jun 12th, 2014 - The Frailty Index (FI) is a known predictor of adverse outcomes in geriatric patients. The usefulness of the FI as an outcome measure in geriatric trauma patients is unknown. To assess the usefulness of the FI as an effective assessment tool in predicting adverse outcomes in geriatric trauma patients. A 2-year (June 2011 to February 2013) prospective cohort study at a level I trauma center at t...

Pediatric mycosis fungoides in Singapore: a series of 46 children.
https://doi.org/10.1111/pde.12352
Pediatric Dermatology; Heng YK, Koh MJ et. al.

Jun 3rd, 2014 - Few studies have evaluated Asian children with mycosis fungoides (MF). We report a series of patients from a tertiary dermatologic institution in Singapore. A retrospective review was performed of patients younger than 16 years old diagnosed with MF between 2000 and 2008 at the National Skin Centre, Singapore. Forty-six patients were identified. At initial presentation, a provisional diagnosis ...

Long-term mortality risk in individuals with atrial or ventricular premature complexes ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334655
The American Journal of Cardiology; Qureshi W, Shah AJ et. al.

May 13th, 2014 - Premature ectopic beats are frequently detected on routine 12-lead screening electrocardiograms (ECGs). However, their prognostic importance in subjects without known cardiovascular disease (CVD) is not well established. We evaluated prognostic value of atrial premature complexes (APCs) and ventricular premature complexes (VPCs) detected by a single 12-lead electrocardiography. A prospective co...

Incidence, presentation, and outcomes in patients with drug-induced liver injury in the...
https://doi.org/10.1053/j.gastro.2013.02.006
Gastroenterology Björnsson ES, Bergmann OM et. al.

Feb 19th, 2013 - Little is known about the incidence of drug-induced liver injury (DILI) in the general population. We investigated the incidence and the quantitative risk of DILI in a population-based cohort. We performed a prospective study and collected data from 96 individuals diagnosed with DILI in Iceland from 2010 through 2011 (54 women; median age, 55 y). Liver injury was defined based on levels of alan...

Early lung ultrasonography predicts the occurrence of acute respiratory distress syndro...
https://doi.org/10.1007/s00134-014-3382-9
Intensive Care Medicine; Leblanc D, Bouvet C et. al.

Jul 15th, 2014 - Extent of lung contusion on initial computed tomography (CT) scan predicts the occurrence of acute respiratory distress syndrome (ARDS) in blunt chest trauma patients. We hypothesized that lung ultrasonography (LUS) on admission could also predict subsequent ARDS. Forty-five blunt trauma patients were prospectively studied. Clinical examination, chest radiography, and LUS were performed on arri...

Vulvar cancers in women with vulvar lichen planus: a clinicopathological study.
https://doi.org/10.1016/j.jaad.2014.05.057
Journal of the American Academy of Dermatology; Regauer S, Reich O et. al.

Jul 7th, 2014 - Vulvar squamous cell carcinomas (SCCs) arising in association with vulvar lichen planus (LP) are poorly documented. We sought to present clinicopathological features of 38 patients (median age 61 years, range 39-90 years) with LP-associated vulvar SCCs. Evaluated were location of vulvar SCC and metastases at presentation, recurrences, survival, precursor lesions, presence of human papillomaviru...

Prognostic value of fasting versus nonfasting low-density lipoprotein cholesterol level...
https://doi.org/10.1161/CIRCULATIONAHA.114.010001
Circulation Doran B, Guo Y et. al.

Jul 12th, 2014 - National and international guidelines recommend fasting lipid panel measurement for risk stratification of patients for prevention of cardiovascular events. However, the prognostic value of fasting versus nonfasting low-density lipoprotein cholesterol (LDL-C) is uncertain. Patients enrolled in the National Health and Nutrition Examination Survey III (NHANES-III), a nationally representative cro...

Administration of secretin (RG1068) increases the sensitivity of detection of duct abno...
https://doi.org/10.1053/j.gastro.2014.05.035
Gastroenterology Sherman S, Freeman ML et. al.

Jun 6th, 2014 - Administration of secretin improves noninvasive imaging of the pancreatic duct with magnetic resonance cholangiopancreatography (MRCP). We performed a large prospective study to investigate whether synthetic human secretin (RG1068)-stimulated MRCP detects pancreatic duct abnormalities with higher levels of sensitivity than MRCP. We performed a phase 3, multicenter, baseline-controlled study of ...

FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for pati...
https://doi.org/10.1016/S1470-2045(14)70330-4
The Lancet. Oncology; Heinemann V, von Weikersthal LF et. al.

Aug 4th, 2014 - Cetuximab and bevacizumab have both been shown to improve outcomes in patients with metastatic colorectal cancer when added to chemotherapy regimens; however, their comparative effectiveness when partnered with first-line fluorouracil, folinic acid, and irinotecan (FOLFIRI) is unknown. We aimed to compare these agents in patients with KRAS (exon 2) codon 12/13 wild-type metastatic colorectal ca...

Cardiac catheterization is associated with superior outcomes for survivors of out of ho...
https://doi.org/10.1016/j.resuscitation.2014.08.025
Resuscitation Camuglia AC, Randhawa VK et. al.

Sep 9th, 2014 - Survivors of out-of-hospital cardiac arrest (OHCA) have a high rate of morbidity and mortality. Invasive cardiac assessment with coronary angiography offers the potential for improving outcomes by facilitating early revascularization. The aim of the present study was to review the published data on early coronary angiography for survivors of OHCA, and its impact on survival and neurological out...

Increased mortality associated with digoxin in contemporary patients with atrial fibril...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405246
Journal of the American College of Cardiology; Turakhia MP, Santangeli P et. al.

Aug 15th, 2014 - Despite endorsement of digoxin in clinical practice guidelines, there exist limited data on its safety in atrial fibrillation/flutter (AF). The goal of this study was to evaluate the association of digoxin with mortality in AF. Using complete data of the TREAT-AF (The Retrospective Evaluation and Assessment of Therapies in AF) study from the U.S. Department of Veterans Affairs (VA) healthcare s...

Regular Aspirin Use and the Risk of Lethal Prostate Cancer in the Physicians' Health St...
https://doi.org/10.1016/j.eururo.2017.01.044
European Urology; Downer MK, Allard CB et. al.

Feb 12th, 2017 - Regular aspirin use probably protects against some malignancies including prostate cancer (PC), but its impact on lethal PC is particularly unclear. To investigate the association between regular aspirin and (1) the risk of lethal PC in a large prospective cohort and (2) survival after PC diagnosis. In 1981/82, the Physicians' Health Study randomized 22 071 healthy male physicians to aspirin, β...

Combination of dabrafenib plus trametinib for BRAF and MEK inhibitor pretreated patient...
https://doi.org/10.1016/S1470-2045(17)30171-7
The Lancet. Oncology; Schreuer M, Jansen Y et. al.

Mar 7th, 2017 - Patients with BRAFV600-mutant melanoma benefit from treatment with the combination of BRAF and MEK inhibitors, but resistance and disease progression develops in most patients. Preclinical studies and case studies have indicated that acquired resistance to BRAF inhibition can be reversible. We aimed to assess the anti-tumour activity of rechallenge with BRAF plus MEK inhibition in a prospective...