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COVID-19 Myths vs. Realities

The swiftly moving novel coronavirus continues its relentless spread around the world, upending life as we know it and creating a breeding ground for misinformation. Some rumors are harmless, while others can be dangerous, stoking fear and threatening health. Here, we separate true from false, based on the best science and expertise available.

The impact of levodopa therapy-induced complications on quality of life in Parkinson’s disease patients in Singapore

The objective of this study was to investigate the impact of levodopa therapy-induced complications on the quality of life (QoL) of Parkinson’s disease (PD) patients in Singapore over a 1-year follow-up period. 274 PD patients were prospectively recruited, of which 78 patients completed the follow-up. Patients were evaluated on: (1) motor symptoms, (2) non-motor symptoms, (3) levodopa therapy-i...

Errands and Going Out

Venturing Out? What to consider before you go.

Physical Activity During the Coronavirus (COVID-19) Pandemic: Prevention of a Decline in Metabolic and Immunological Functions

As of 30th January 2020, the outbreak of the novel coronavirus disease, later called COVID-19, was declared a Public Health Emergency (World Health Organization, 2020b) and on the 11th of March 2020, COVID-19 was characterized as a pandemic (World Health Organization, 2020d). On April 20th 2020, WHO reported 2,314,621 confirmed cases of COVID-19 and a total of 157,847 deaths from all regions of...

ECOG-ACRIN Trial Reassures Clinicians, Patients That Locoregional Therapy Is Not Beneficial for Stage IV Metastatic Breast Cancer

Jun 23rd, 2020 - For patients with stage IV metastatic breast cancer and an intact primary tumor (ITP), the early initiation of locoregional treatment (LRT) was not associated with longer survival or improvements in health-related quality of life (HRQoL) compared with systemic therapy alone, according to a phase III clinical trial (Abstract LBA2). These findings appear to add to a robust evidence base that sugg...

Coronavirus misinformation, and how scientists can help to fight it

Eating sea lettuce or injecting disinfectant won’t prevent you from getting COVID-19. Holding your breath for ten seconds is not a test for SARS-CoV-2. And Russian President Vladimir Putin did not release 500 lions in Moscow to persuade the city’s residents to stay indoors as part of the efforts to fight the pandemic. The rapid global spread of COVID-19 has been accompanied by what the World He...

Two immunocompromised patients with diffuse alveolar hemorrhage as a complication of severe COVID-19

Diffuse alveolar hemorrhage (DAH) is a severe and potentially life-threatening disease manifestation. Besides autoimmune diseases such as anti-neutrophil cytoplasmatic antibody (ANCA) associated vasculitis and anti-glomerular basement membrane (anti-GBM) syndrome pulmonary viral infections are also known to be culprits of DAH. The coronavirus disease 2019 (COVID-19) pandemic confronts healthcar...

Recommendations to Optimize the Safety of Elective Surgical Care While Limiting the Spread of COVID-19: Primum Non Nocere

COVID-19 has drastically altered our lives in an unprecedented manner, shuttering industries and leaving most of the country in isolation as we adapt to the evolving crisis. Orthopedic surgery has not been spared from these effects, with the postponement of elective procedures in an attempt to mitigate disease transmission and preserve hospital resources as the pandemic continues to expand. Dur...

Olaparib shows 1-year survival benefit in recurrent ovarian cancer, BRCA mutations

Jul 6th, 2020 - Overall survival results from SOLO-2 showed patients with recurrent ovarian cancer and germline BRCA mutations added a year of life when treated with olaparib only, Ursula A. Matulonis, MD, of Dana Farber Cancer Institute, told Healio.

Impact of COVID-19 Attributable Deaths on Longevity, Premature Mortality and DALY: Estimates of USA, Italy, Sweden and Germany

In a short span of four months, the COVID-19 pandemic has added over 0.4 million deaths worldwide, which are untimely, premature and unwarranted. The USA, Italy, Germany and Sweden are four worst affected countries, accounting to over 40% of COVID-19 deaths globally. The main objective of this study is to examine the impact of COVID-19 attributable deaths on longevity, years of potential li...

Complications of Shingles

PHN occurs in the areas where the shingles rash was, even after the rash clears up. It can last for months or years after the rash goes away. The pain from PHN can be so severe and debilitating that it interferes with daily life. About 10 to 18% of people who get shingles will experience PHN. Your risk of PHN increases with age. An older adult with shingles is more likely to develop PHN and ...

Association of herpes zoster with dementia and effect of antiviral therapy on dementia: a population-based cohort study

We investigated the association between herpes zoster (HZ) and dementia, and the effects of antiviral therapy on the risk of dementia. We used the National Health Insurance Service-National Sample Cohort in South Korea to identify individuals that were followed from January 1, 2002, to December 31, 2013. Occurrences of HZ and dementia were identified using the relevant diagnostic codes. Shing...

Shingles: Hope Through Research

hingles is the reactivation of a viral infection in the nerves to the skin that causes pain, burning, or a tingling sensation, along with an itch and blisters in the skin supplied by the affected nerve. It is caused by the varicella zoster virus[1], or VZV—the same virus that causes chickenpox. When the itchy red spots of childhood chickenpox disappear, the virus remains in a dormant state in...

Preventing Varicella-Zoster Virus (VZV) Transmission from Herpes Zoster in Healthcare Settings

Infection-control measures depend on whether the patient with herpes zoster is immunocompetent or immunocompromised and whether the rash is localized or disseminated (defined as appearance of lesions outside the primary or adjacent dermatomes). In all cases, follow standard infection-control precautions. Use the chart below to determine if any additional infection-protocol precautions are re...

Herpes Zoster and Postherpetic Neuralgia: An Examination of Psychological Antecedents

Herpes zoster and an associated complication, postherpetic neuralgia, are both attributable to the varicella zoster virus. This virus, which lies dormant within the affected sensory ganglia after an initial infection, appears to be triggered in part by a decrease in immunity. According to available research, stress, stressful life events, and depressive symptoms are identified antecedents to ou...

Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19

Traveller screening is being used to limit further spread of COVID-19 following its recent emergence, and symptom screening has become a ubiquitous tool in the global response. Previously, we developed a mathematical model to understand factors governing the effectiveness of traveller screening to prevent spread of emerging pathogens (Gostic et al., 2015). Here, we estimate the impact of differ...

COVID-19, obsessive-compulsive disorder and invisible life forms that threaten the self

Covid-19 pandemic and the skin - What should dermatologists know?
Clinics in Dermatology;

The World has changed dramatically since the COVID-19 pandemic began. Together with our social, occupational, and personal life, the new corona virus poses novel challenges for all physicians, including dermatologists. Despite the virus not being dermatotropic, several skin conditions have emerged, mainly as a result of prolonged contact to personal protective equipment and excessive personal h...

Cancer Pain (PDQ®)–Health Professional Version

Pain is one of the most common symptoms in cancer patients and often has a negative impact on patients’ functional status and quality of life. The goal of the following summary is to provide evidence-based, up-to-date, and practical information on the management of cancer pain.

Levodopa‐induced dyskinesia in Parkinson's disease: clinical features, pathogenesis, prevention and treatment
Postgraduate Medical Journal;

Jun 4th, 2007 - Levodopa is the most effective drug for treating Parkinson's disease. However, long‐term use of levodopa is often complicated by significantly disabling fluctuations and dyskinesias negating its beneficial effects. Younger age of Parkinson's disease onset, disease severity, and high levodopa dose increase the risk of development of levodopa‐induced dyskinesias (LID). The underlying mechanisms f...