×
About 157,020 results

Benefits, harms, and cost-effectiveness of supplemental ultrasonography screening for w...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314343
Annals of Internal Medicine; Sprague BL, Stout NK et. al.

Dec 8th, 2014 - Many states have laws requiring mammography facilities to tell women with dense breasts and negative results on screening mammography to discuss supplemental screening tests with their providers. The most readily available supplemental screening method is ultrasonography, but little is known about its effectiveness. To evaluate the benefits, harms, and cost-effectiveness of supplemental ultraso...

Breast Tumor Prognostic Characteristics and Biennial vs Annual Mammography, Age, and Me...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644100
JAMA Oncology; Miglioretti DL, Zhu W et. al.

Oct 26th, 2015 - Screening mammography intervals remain under debate in the United States. To compare the proportion of breast cancers with less vs more favorable prognostic characteristics in women screening annually vs biennially by age, menopausal status, and postmenopausal hormone therapy (HT) use. This was a study of a prospective cohort from 1996 to 2012 at Breast Cancer Surveillance Consortium facilities...

Brown adipose tissue transplantation ameliorates polycystic ovary syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790997
Proceedings of the National Academy of Sciences of the Un... Yuan X, Hu T et. al.

Feb 23rd, 2016 - Polycystic ovary syndrome (PCOS), which is characterized by anovulation, hyperandrogenism, and polycystic ovaries, is a complex endocrinopathy. Because the cause of PCOS at the molecular level is largely unknown, there is no cure or specific treatment for PCOS. Here, we show that transplantation of brown adipose tissue (BAT) reversed anovulation, hyperandrogenism, and polycystic ovaries in a de...

Variation in Mammographic Breast Density Assessments Among Radiologists in Clinical Pra...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050130
Annals of Internal Medicine; Sprague BL, Conant EF et. al.

Jul 18th, 2016 - About half of the United States has legislation requiring radiology facilities to disclose mammographic breast density information to women, often with language recommending discussion of supplemental screening options for women with dense breasts. To examine variation in breast density assessment across radiologists in clinical practice. Cross-sectional and longitudinal analyses of prospective...

Synaptic glutamate spillover due to impaired glutamate uptake mediates heroin relapse.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988415
The Journal of Neuroscience : the Official Journal of The... Shen HW, Scofield MD et. al.

Apr 17th, 2014 - Reducing the enduring vulnerability to relapse is a therapeutic goal in treating drug addiction. Studies with animal models of drug addiction show a marked increase in extrasynaptic glutamate in the core subcompartment of the nucleus accumbens (NAcore) during reinstated drug seeking. However, the synaptic mechanisms linking drug-induced changes in extrasynaptic glutamate to relapse are poorly u...

Accounting for the delay in the transition from acute to chronic pain: axonal and nucle...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293406
The Journal of Neuroscience : the Official Journal of The... Ferrari LF, Bogen O et. al.

Jan 15th, 2015 - Acute insults produce hyperalgesic priming, a neuroplastic change in nociceptors that markedly prolongs inflammatory mediator-induced hyperalgesia. After an acute initiating insult, there is a 72 h delay to the onset of priming, for which the underlying mechanism is unknown. We hypothesized that the delay is due to the time required for a signal to travel from the peripheral terminal to the cel...

Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293402
The Journal of Neuroscience : the Official Journal of The... McKelvey R, Berta T et. al.

Jan 15th, 2015 - Peripheral nerve injury can trigger neuropathic pain in adults but not in infants; indeed, for unknown reasons, neuropathic pain is rare before adolescence. We show here that the absence of neuropathic pain response in infant male rats and mice following nerve injury is due to an active, constitutive immune suppression of dorsal horn pain activity. In contrast to adult nerve injury, which trigg...

Change in Breast Cancer Screening Intervals Since the 2009 USPSTF Guideline.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576213
Journal of Women's Health (2002); Wernli KJ, Arao RF et. al.

Feb 8th, 2017 - In 2009, the U.S. Preventive Services Task Force (USPSTF) recommended biennial mammography for women aged 50-74 years and shared decision-making for women aged 40-49 years for breast cancer screening. We evaluated changes in mammography screening interval after the 2009 recommendations. We conducted a prospective cohort study of women aged 40-74 years who received 821,052 screening mammograms b...

Identifying women with dense breasts at high risk for interval cancer: a cohort study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443857
Annals of Internal Medicine; Kerlikowske K, Zhu W et. al.

May 19th, 2015 - Twenty-one states have laws requiring that women be notified if they have dense breasts and that they be advised to discuss supplemental imaging with their provider. To better direct discussions of supplemental imaging by determining which combinations of breast cancer risk and Breast Imaging Reporting and Data System (BI-RADS) breast density categories are associated with high interval cancer ...

Trends in Clinical Breast Density Assessment From the Breast Cancer Surveillance Consortium
https://academic.oup.com/jnci/advance-article-abstract/doi/10.1093/jnci/djy210/5280767?redirectedFrom=fulltext
Sprague,B.,et al

Jan 7th, 2019 - Changes to mammography practice, including revised Breast Imaging Reporting and Data System (BI-RADS) density classification guidelines and implementation of digital breast tomosynthesis (DBT), may impact clinical breast density assessment. We investigated temporal trends in clinical breast density assessment among 2 990 291 digital mammography (DM) screens and 221 063 DBT screens interpreted b...

Physical exercise increases adult hippocampal neurogenesis in male rats provided it is ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818598
The Journal of Physiology; Nokia MS, Lensu S et. al.

Feb 4th, 2016 - Aerobic exercise, such as running, enhances adult hippocampal neurogenesis (AHN) in rodents. Little is known about the effects of high-intensity interval training (HIT) or of purely anaerobic resistance training on AHN. Here, compared with a sedentary lifestyle, we report a very modest effect of HIT and no effect of resistance training on AHN in adult male rats. We found the most AHN in rats th...

Pre-trauma Methylphenidate in rats reduces PTSD-like reactions one month later.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545737
Translational Psychiatry; Ritov G, Richter-Levin G

Jan 10th, 2017 - In basic research, the etiology of fear-related pathologies, such as post-traumatic stress disorder (PTSD), is conceptualized using fear-conditioning protocols that pair environmental stimuli (that is, a conditioned stimulus-CS) with an aversive, unconditioned stimulus (US) to elicit an assessable conditioned fear response. Although pathophysiological models agree that regulatory dysfunctions i...

Knowledge, Attitudes, and Beliefs Regarding Cardiovascular Disease in Women: The Women'...
https://doi.org/10.1016/j.jacc.2017.05.024
Journal of the American College of Cardiology; Bairey Merz CN, Andersen H et. al.

Jun 26th, 2017 - Cardiovascular disease (CVD) is the number 1 killer of women in the United States, yet few younger women are aware of this fact. CVD campaigns focus little attention on physicians and their roles in assessing risk. In 2014, the Women's Heart Alliance (WHA) conducted a nationwide survey to determine barriers and opportunities for women and physicians with regard to CVD. From September 18 to 26, ...

Performance of Screening Ultrasonography as an Adjunct to Screening Mammography in Wome...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503561
JAMA Internal Medicine; Lee JM, Arao RF et. al.

Mar 18th, 2019 - Whole-breast ultrasonography has been advocated to supplement screening mammography to improve outcomes in women with dense breasts. To determine the performance of screening mammography plus screening ultrasonography compared with screening mammography alone in community practice. Observational cohort study. Two Breast Cancer Surveillance Consortium registries provided prospectively collected ...

Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938858
The Journal of Neuroscience : the Official Journal of The... Titus DJ, Wilson NM et. al.

Jul 7th, 2016 - Learning and memory impairments are common in traumatic brain injury (TBI) survivors. However, there are no effective treatments to improve TBI-induced learning and memory impairments. TBI results in decreased cAMP signaling and reduced cAMP-response-element binding protein (CREB) activation, a critical pathway involved in learning and memory. TBI also acutely upregulates phosphodiesterase 4B2 ...

24-Hour Pharmacokinetic Relationships for Vancomycin and Novel Urinary Biomarkers of Ac...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655072
Antimicrobial Agents and Chemotherapy; O'Donnell JN, Rhodes NJ et. al.

Aug 15th, 2017 - Vancomycin has been associated with acute kidney injury in preclinical and clinical settings; however, the precise exposure profiles associated with vancomycin-induced acute kidney injury have not been defined. We sought to determine pharmacokinetic/pharmacodynamics indices associated with the development of acute kidney injury using sensitive urinary biomarkers. Male Sprague-Dawley rats receiv...

Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsych...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315552
Translational Psychiatry; Seeman P

Oct 18th, 2016 - Although all current antipsychotics act by interfering with the action of dopamine at dopamine D2 receptors, two recent reports showed that 800 to 1000 mg of cannabidiol per day alleviated the signs and symptoms of schizophrenia, although cannabidiol is not known to act on dopamine receptors. Because these recent clinical findings may indicate an important exception to the general rule that all...

Strategies to Identify Women at High Risk of Advanced Breast Cancer During Routine Scre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604099
JAMA Internal Medicine; Kerlikowske K, Sprague BL et. al.

Jul 1st, 2019 - Federal legislation proposes requiring that screening mammography reports to practitioners and women incorporate breast density information and that women with dense breasts discuss supplemental imaging with their practitioner given their increased risk of interval breast cancer. Instead of discussing supplemental imaging with all women with dense breasts, it may be more efficient to identify w...

Vaporized Cannabis Extracts Have Reinforcing Properties and Support Conditioned Drug-Se...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046447
The Journal of Neuroscience : the Official Journal of The... Freels TG, Baxter-Potter LN et. al.

Jan 18th, 2020 - Recent trends in cannabis legalization have increased the necessity to better understand the effects of cannabis use. Animal models involving traditional cannabinoid self-administration approaches have been notoriously difficult to establish and differences in the drug used and its route of administration have limited the translational value of preclinical studies. To address this challenge in ...

Nitrated meat products are associated with mania in humans and altered behavior and bra...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077736
Molecular Psychiatry; Khambadkone SG, Cordner ZA et. al.

Jul 19th, 2018 - Mania is a serious neuropsychiatric condition associated with significant morbidity and mortality. Previous studies have suggested that environmental exposures can contribute to mania pathogenesis. We measured dietary exposures in a cohort of individuals with mania and other psychiatric disorders as well as in control individuals without a psychiatric disorder. We found that a history of eating...