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An Open Letter from Daniel O’Day, Chairman & CEO, Gilead Sciences

After receiving the green light from the FDA to move forward, Gilead is about to start trials of an inhaled version of remdesivir. We will screen healthy volunteers for Phase 1 trials this week and hope to begin studies in patients with COVID-19 in August. If the trials are successful, this could represent important progress. Remdesivir, our investigational antiviral medicine, is currently give...

Disappearance of Antibodies to SARS-Associated Coronavirus after Recovery
The New England Journal of Medicine;

Previous studies have demonstrated that IgG and neutralizing antibodies against coronavirus associated with the severe acute respiratory syndrome (SARS) may persist, in spite of a decline in titer, for 2 years in patients who have recovered from SARS.

COVID-19 in Racial and Ethnic Minority Groups

The effects of COVID-19 on the health of racial and ethnic minority groups is still emerging; however, current data suggest a disproportionate burden of illness and death among racial and ethnic minority groups. A recent CDC MMWR report included race and ethnicity data from 580 patients hospitalized with lab-confirmed COVID-19 found that 45% of individuals for whom race or ethnicity data was av...

Update Alert: Epidemiology of and Risk Factors for Coronavirus Infection in Health Care Workers

This is the first monthly update alert for a living review on the epidemiology of and risk factors for coronavirus infections in health care workers (HCWs) (1). Searches were updated from 24 April 2020 to 24 May 2020, using the same search strategies as the original review, and we identified 1125 citations. Applying the same inclusion criteria, we identified 37 additional studies for this updat...

Seasonality of Respiratory Viral Infections

The seasonal cycle of respiratory viral diseases has been widely recognized for thousands of years, as annual epidemics of the common cold and influenza disease hit the human population like clockwork in the winter season in temperate regions. Moreover, epidemics caused by viruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and the newly emerging SARS-CoV-2 occur during ...

SARS-CoV-2 and Nervous System - Neurological Manifestations in Patients With COVID-19: A Systematic Review

Coronavirus (CoV) is a virus infectious disease with a considerable spectrum of clinical presentations. Symptoms ranged from asymptomatic infection to severe pneumonia that may lead to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and several clinical complications. Neurologic symptoms related to CoV have been described recently in the literature. The relationship between SARS-Co...

Low Carbohydrate Diet

Since 1860, and more recently, in 1972, low carbohydrate (low-carb) diets have been a strategy for weight loss. Today, there continues to be an interest in low-carb approaches. While all low carbohydrate approaches reduce the overall intake of carbohydrates, there is no clear consensus on what defines a low-carb diet. There are three macronutrients—carbohydrates (4 kcal/gm), fat (9 kcal/gm),...

Molecular Interaction Studies of Garlic Active Compound for Lowering Down the Blood Pressure Using Bioinformatics Approach

High Blood pressure is regarded as “silent killer” because person may not feel that something is happening wrong in the body, but it can quietly cause damage that can threaten health. Non-pharmacological approaches, such as alternative / complementary medicine have potential to reduce cardiovascular risk factor such as high blood pressure. Garlic supplements i.e. phytochemicals plays an imp...

Breast Cancer Research at ASCO20 Virtual Scientific Program Highlights New Avenues and Better Outcomes

Jun 24th, 2020 - The ASCO20 Virtual Scientific Program featured a variety of important and innovative breast cancer research. The following are some of the studies with potential to significantly impact clinical practice and patient outcomes, as selected by ASCO Daily News Expert Panel member Arielle Heeke, MD, of the Levine Cancer Institute.

Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen

Review Article Published: 12 June 2020 Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen Fatemeh Heidary & Reza Gharebaghi The Journal of Antibiotics (2020)Cite this article 57k Accesses 375 Altmetric Metricsdetails Abstract Ivermectin proposes many potentials effects to treat a range of diseases, with its antimicrobial, antiviral, and an...

COVID-19 in Immunocompromised Hosts: What We Know So Far
Clinical Infectious Diseases; Monica Fung MD, MPH et. al.

Jun 26th, 2020 - The coronavirus disease 2019 (COVID-19) pandemic caused by SARS coronavirus 2 (SARS-CoV-2) has caused significant morbidity and mortality for patients and stressed healthcare systems worldwide. The clinical features and outcomes of COVID-19 among immunosuppressed patients, who are at presumed risk for more severe disease but who may also have decreased detrimental inflammatory responses, are no...

Expression of the COVID‐19 receptor ACE2 in the human conjunctiva

SARS‐CoV‐2 is assumed to use angiotensin‐converting enzyme 2 (ACE2 ) and other auxiliary proteins for cell entry. Recent studies have described conjunctival congestion in 0.8% of patients with laboratory‐confirmed severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), and there has been speculation that SARS‐CoV‐2 can be transmitted through the conjunctiva. However, it is currently uncle...

Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID position paper

The coronavirus disease 2019 (COVID-19) pandemic poses an enormous challenge to healthcare systems in affected communities. Older patients and those with pre-existing medical conditions have been identified as populations at risk of a severe disease course. It remains unclear at this point to what extent chronic liver diseases should be considered as risk factors, due to a shortage of appropria...

Implications for the use of telehealth in surgical patients during the COVID-19 pandemic

The COVID-19 pandemic has placed an unprecedented burden on healthcare systems across the globe. In efforts to mitigate transmission and spread of the virus, social distancing, closure of public spaces, and quarantines have been implemented across the country. Despite the unfolding pandemic, other diseases require treatment, and will through what could be months of social distancing in the fore...

Liver injury in COVID-19: The current evidence

Patients with novel coronavirus disease 2019 (COVID-19) experience various degrees of liver function abnormalities. Liver injury requires extensive work-up and continuous surveillance and can be multifactorial and heterogeneous in nature. In the context of COVID-19, clinicians will have to determine whether liver injury is related to an underlying liver disease, drugs used for the treatment of ...

Is cannabidiol the ideal drug to treat non-motor Parkinson’s disease symptoms?
European Archives of Psychiatry and Clinical Neuroscience;

Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rest tremor, postural disturbances, and rigidity. PD is also characterized by non-motor symptoms such as sleep disturbances, cognitive deficits, and psychiatric disorders such as psychosis, depression, and anxiety. The pharmacological treatment for these symptoms is limited in ...

Safety and tolerability of IRL790 in Parkinson’s disease with levodopa-induced dyskinesia—a phase 1b trial
NPJ Parkinson's Disease;

IRL790 is a novel compound with psychomotor stabilizing properties primarily targeting the dopamine D3 receptor. IRL790 is developed as an experimental treatment for levodopa-induced dyskinesia (LID), impulse control disorder, and psychosis in Parkinson’s disease (PD). The primary objective was to investigate the safety and tolerability of IRL790 in PD patients with LID in a randomized controll...

Patient survival greatly impacted by selection for ovarian cancer relapse surgery

Jul 6th, 2020 - Studies presented during the ASCO2020 Virtual Scientific Program showed the benefit of validated selection tools in pursuing surgical measures for ovarian cancer relapse, Ursula A. Matulonis, MD, of Dana Farber Cancer Institute, told Healio.

Herpes Zoster and Postherpetic Neuralgia: An Examination of Psychological Antecedents

Herpes zoster and an associated complication, postherpetic neuralgia, are both attributable to the varicella zoster virus. This virus, which lies dormant within the affected sensory ganglia after an initial infection, appears to be triggered in part by a decrease in immunity. According to available research, stress, stressful life events, and depressive symptoms are identified antecedents to ou...

The serotonergic system in Parkinson’s patients with dyskinesia: evidence from imaging studies

The purpose of review is to review the current status of positron emission tomography (PET) molecular imaging of serotonergic system in Parkinson’s patients who experience levodopa-induced (LIDs) and graft-induced dyskinesias (GIDs). PET imaging studies have shown that Parkinson’s disease is characterized by progressive loss of dopaminergic and serotonergic neurons. Parkinson’s patients who exp...