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About 963,215 results

Levodopa‐induced dyskinesia in Parkinson's disease: clinical features, pathogenesis, prevention and treatment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600052/
Postgraduate Medical Journal;

Jun 5th, 2007 - Levodopa is the most effective drug for treating Parkinson's disease. However, long‐term use of levodopa is often complicated by significantly disabling fluctuations and dyskinesias negating its beneficial effects. Younger age of Parkinson's disease onset, disease severity, and high levodopa dose increase the risk of development of levodopa‐induced dyskinesias (LID). The underlying mechanisms f...

Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310186/
Vaccines Xia X.

Jul 3rd, 2021 - The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each injection leading to more efficient immunization programs. The mRNA components of the vaccine need to have a 5′-UTR to load ribosomes efficiently onto the mRNA for translation initiation, optimized codon usage for efficie...

Efficacy and safety of current medications for treating severe and non-severe COVID-19 ...
https://doi.org/10.18632/aging.203522
Aging Cheng Q, Chen J et. al.

Sep 18th, 2021 - Many recent studies have investigated the role of drug interventions for coronavirus disease 2019 (COVID-19) infection. However, an important question has been raised about how to select the effective and secure medications for COVID-19 patients. The aim of this analysis was to assess the efficacy and safety of the various medications available for severe and non-severe COVID-19 patients based ...

Treatment of GM2 Gangliosidosis in Adult Sandhoff Mice using an Intravenous Self-Comple...
https://doi.org/10.2174/1566523221666210916153051
Current Gene Therapy; Osmon KJ, Thompson P et. al.

Sep 18th, 2021 - GM2 gangliosidosis is a neurodegenerative, lysosomal storage disease caused by the deficiency of β-hexosaminidase A enzyme (HexA), an α/β-subunit heterodimer. A novel variant of the human hexosaminidase α-subunit, coded by HEXM, has previously been shown to form a stable homodimer, HexM, that hydrolyzes GM2 gangliosides (GM2) in vivo. The current study assessed the efficacy of intravenous (IV) ...

Optimization assisted Kalman filter for cancer chemotherapy dosage estimation.
https://doi.org/10.1016/j.artmed.2021.102152
Artificial Intelligence in Medicine; Mohite UL, Patel HG

Sep 18th, 2021 - Cancer is regarded to be the earth's most deadly disease, with one of the highest mortality rates among people. "Surgery, radiotherapy, chemotherapy, hormone therapy, and immunotherapy" were all options for treat cancer. Chemotherapy is a medication that is most often deployed for treating cancer, as cancer cells develop and proliferate faster than other cells in the body. Even though chemother...

Differential Expression of Long Noncoding RNAs Reveals a Potential Biomarker for Intrac...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440090
Disease Markers; Qu P, Huang Z et. al.

Sep 18th, 2021 - Long noncoding RNAs (lncRNAs) are involved in autoimmune diseases. However, the role of lncRNAs in pemphigus remains elusive. The study is aimed at investigating the expression profile in pemphigus patients to identify a circulating lncRNA as a novel biomarker for pemphigus. A global lncRNA expression profile in peripheral blood mononuclear cells (PBMCs) was measured by lncRNA microarray. Diffe...

Effect of intermittent pneumatic compression with different inflation pressures on the ...
https://doi.org/10.1111/iwj.13693
International Wound Journal; Ren W, Duan Y et. al.

Sep 17th, 2021 - Intermittent pneumatic compression (IPC) is commonly used to improve peripheral circulation of the lower extremity. However, its therapeutic dosage for people with type 2 diabetes mellitus (DM) at risk for ulcers is not well established. This study explored the effect of IPC with different inflation pressures on the distal microvascular responses of the foot in people with type 2 DM. Twenty-fou...

3D Printing: an appealing technology for the manufacturing of solid oral dosage forms.
https://doi.org/10.1093/jpp/rgab136
The Journal of Pharmacy and Pharmacology; Pitzanti G, Mathew E et. al.

Sep 17th, 2021 - The traditional manufacturing methods of solid oral dosage forms (SODFs) are reported to be time-consuming, highly expensive and not tailored to the patient's needs. Three-dimensional printing (3DP) is an innovative emerging technology that can help to overcome these issues. The aim of this review is to describe the most employed 3DP technologies, materials and the state of the art on 3DP SODFs...

Effects of single and multiple transplantations of human umbilical cord mesenchymal ste...
https://doi.org/10.1186/s13048-021-00871-4 10.3171/2018.12.FOCUS18602 10.1097/MNH.0000000000000461 10.1097/MOT.0000000000000379 10.3390/cells9102253 10.1159/000447857 10.1155/2018/7318513 10.1002/jemt.23120 10.1155/2014/720753 10.1038/s41374-019-0321-y 10.4252/wjsc.v6.i2.195 10.2174/1574888X14666191119122159 10.1016/j.tem.2018.03.010 10.1016/j.bioactmat.2020.12.008 10.4103/jhrs.JHRS_57_18 10.1186/s13287-019-1136-x 10.1186/s13048-020-00671-2 10.1371/journal.pone.0069129 10.1016/j.cellimm.2016.01.002 10.1186/1471-213X-13-34 10.1634/stemcells.2005-0342 10.1267/ahc.20-00032 10.1186/s13048-020-00671-2 10.1002/jcp.29376 10.1002/rmb2.12268 10.1186/s12967-019-02149-2 10.1016/j.fertnstert.2020.07.001 10.1186/s13578-019-0360-5 10.1097/GCO.0000000000000268 10.3390/ijms18091852 10.1177/1933719117699705 10.1186/s13256-017-1489-7 10.1186/s13287-015-0152-8 10.1186/s12964-015-0124-8 10.1007/s12291-017-0641-x 10.1111/j.1365-2184.2007.00414.x 10.1007/s11626-010-9316-0 10.1095/biolreprod.105.046029 10.1002/term.2914 10.1038/nature00870 10.3727/096368910X564076 10.1038/nri2156 10.14348/molcells.2014.0145 10.1002/jemt.22725 10.1371/journal.pone.0106538 10.29252/ibj.23.3.200 10.1016/j.ecl.2015.05.004 10.1371/journal.pone.0106538 10.1016/S0015-0282(01)03201-0 10.1002/(SICI)1096-9896(200004)190:5<537::AID-PATH577>3.0.CO;2-W
Journal of Ovarian Research; Lv X, Guan C et. al.

Sep 17th, 2021 - Currently, there is no effective treatment for premature ovarian failure (POF), and stem cell therapy is considered the most promising treatment. Human umbilical cord blood mesenchymal stem cells (hUC-MSCs) have shown good regenerative ability in various diseases, including POF; however, their underlying mechanism and dosage for POF treatment remain unclear. This study aimed to compare the effe...

Level of adherence to vitamin D supplementation guidelines in an antenatal centre in Bi...
https://doi.org/10.1136/bmjopen-2021-048705
BMJ Open; Yamanouchi L, Srinivasan M et. al.

Sep 17th, 2021 - A third of pregnant women in the UK are vitamin D deficient, which may confer deleterious consequences, including an increased risk of pre-eclampsia, gestational diabetes mellitus and intrauterine growth restriction. This study aims to determine the proportion of women that met National Institute for Health and Care Excellence (NICE) standards for vitamin D supplementation in pregnancy and comp...

The efficacy of corticosteroids therapy in patients with moderate to severe SARS-CoV-2 ...
https://doi.org/10.1186/s12931-021-01833-6 10.1001/jama.2020.4031 10.1016/j.carpath.2020.107233 10.1038/s41392-019-0089-y 10.1016/j.autrev.2020.102567 10.1016/S0140-6736(20)30628-0 10.1016/j.jcrc.2020.07.002 10.1016/S2213-2600(20)30076-X 10.1007/s00134-020-06057-8 10.1016/S2213-2600(20)30079-5 10.1056/NEJMoa2002032 10.1016/S0140-6736(20)30183-5 10.1016/S0140-6736(20)30317-2 10.1016/S0140-6736(20)30361-5 10.1016/j.resp.2020.103492 10.1093/cid/ciaa601 10.1186/s13098-019-0485-z 10.1016/S2213-8587(20)30238-2 10.1093/cid/ciaa1177 10.1016/j.cmi.2020.09.014 10.1183/13993003.00607-2020 10.1111/joim.13063 10.1016/j.ijid.2020.09.1454 10.1016/j.jinf.2020.03.037
Respiratory Research; Ghanei M, Solaymani-Dodaran M et. al.

Sep 17th, 2021 - We performed a multicenter, randomized open-label trial in patients with moderate to severe Covid-19 treated with a range of possible treatment regimens. Patients were randomly assigned to one of three regimen groups at a ratio of 1:1:1. The primary outcome of this study was admission to the intensive care unit. Secondary outcomes were intubation, in-hospital mortality, time to clinical recover...

Assessment of malaria infection among pregnant women and children below five years of a...
https://doi.org/10.1371/journal.pone.0257276
PloS One; Okoyo C, Githinji E et. al.

Sep 17th, 2021 - In Kenya, health service delivery and access to health care remains a challenge for vulnerable populations, particularly pregnant women and children below five years. The aim of this study, therefore, was to determine the positivity rate of Plasmodium falciparum parasites in pregnant women and children below five years of age seeking healthcare services at the rural health facilities of Kwale a...

The Genetic Basis of Moyamoya Disease.
https://doi.org/10.1007/s12975-021-00940-2 10.1001/archneur.1969.00480090076012 10.3171/2015.4.JNS142936 10.1056/NEJMra0804622 10.1111/j.1468-1331.2006.01417.x 10.1007/s11910-019-0932-0 10.1177/1747493017694393 10.1136/jnnp.2007.130666 10.1016/j.clineuro.2009.11.009 10.1161/STROKEAHA.113.004273 10.1136/jnnp-2011-301387 10.3171/foc.1998.5.5.4 10.1016/s0303-8467(97)00037-1 10.1212/01.wnl.0000176066.33797.82 10.1007/978-3-319-73739-3_13 10.3109/02688697.2015.1096902 10.1111/ene.12702 10.1007/s007010070024 10.1161/01.STR.0000221787.70503.ca 10.1177/0883073817718730 10.3171/ped.2005.103.5.0439 10.1016/j.clineuro.2016.11.017 10.1097/00029679-200005150-00001 10.1159/000326077 10.1007/s00701-016-2941-y 10.1161/STROKEAHA.117.018563 10.1016/j.wneu.2015.08.037 10.1093/neuros/nyx122 10.1016/j.nec.2010.03.008 10.1016/S1474-4422(08)70240-0 10.1046/j.1440-1789.2000.00300.x 10.2176/nmc.47.1 10.1159/000442298 10.2174/092986732304160204181543 10.1161/STROKEAHA.107.501759 10.1007/s00701-019-03811-w 10.1177/0271678X16658301 10.2174/156720206778018730 10.3171/jns.1983.58.1.0120 10.1093/neuros/nyy236 10.1161/01.str.21.7.1044 10.1212/01.wnl.0000257095.33125.48 10.1016/s0303-8467(97)00048-6 10.1016/s0387-7604(02)00005-0 10.1016/s0303-8467(97)00049-8 10.1136/jnnp.2006.096040 10.1161/STROKEAHA.120.029251 10.1111/j.1468-1331.2011.03536.x 10.1161/STROKEAHA.118.023972 10.1001/archneur.56.6.667 10.1038/nrg3908 10.1086/302243 10.1177/088307380001500307 10.1007/s10038-004-0143-6 10.1161/01.str.31.4.930 10.1007/s00381-004-1005-4 10.1212/01.wnl.0000291012.49986.f9 10.1007/s12199-009-0116-7 10.1038/jhg.2010.132 10.1371/journal.pone.0022542 10.1086/324069 10.1126/science.273.5281.1516 10.1056/NEJMra0905980 10.1007/s00428-018-2501-3 10.1136/jnnp.45.11.1048 10.1161/01.str.26.3.415 10.1016/s0303-8467(97)00051-6 10.3346/jkms.2003.18.6.876 10.3340/jkns.2009.46.6.558 10.1007/s00701-011-1261-5 10.1371/journal.pone.0220858 10.1056/NEJM199312303292706 10.1016/j.ceca.2004.02.011 10.1007/s00381-011-1504-z 10.1177/0271678X16655551 10.1038/nrn1106 10.1177/0271678X18768443 10.1227/01.NEU.0000215854.66011.4F 10.1007/s00381-010-1241-8 10.1159/000319893 10.1016/j.gene.2013.05.083 10.1186/s12883-014-0180-5 10.1016/j.jocn.2014.08.034 10.1161/STROKEAHA.120.029527 10.1161/STROKEAHA.108.529420 10.1136/jnnp.2009.191817 10.1016/j.cell.2019.01.021 10.1371/journal.pone.0047158 10.3892/etm.2014.1713 10.1161/ATVBAHA.107.161521 10.1161/ATVBAHA.120.314948 10.1152/physrev.1999.79.4.1283 10.1002/jcp.1041470202 10.1002/jcp.1041540210 10.1007/s00701-010-0711-9 10.3171/jns.1998.89.4.0623 10.1016/j.ejmg.2012.05.002 10.1016/j.neulet.2012.05.062 10.11477/mf.1436203169 10.1080/02688697.2018.1559275 10.7717/peerj.8841 10.1534/g3.115.020321 10.1038/s41436-019-0639-2 10.1371/journal.pone.0221811 10.1136/jmedgenet-2019-106525 10.1001/jamaneurol.2021.1681 10.1038/srep04442 10.3171/2015.4.JNS142900 10.1212/WNL.0b013e318249f71f 10.3171/2016.2.JNS152173 10.1161/STROKEAHA.117.017430 10.1212/WNL.0000000000008901 10.1186/s12881-015-0252-4 10.1159/000499699 10.1371/journal.pone.0179689 10.1371/journal.pone.0048179 10.1186/s12199-017-0680-1 10.1161/STROKEAHA.114.006244 10.1007/s12041-013-0304-5 10.23736/S0390-5616.16.03900-X 10.1038/s41439-019-0066-6 10.1212/WNL.0000000000011653 10.1371/journal.pone.0164759 10.1038/ejhg.2017.92 10.1161/STROKEAHA.112.663864 10.4103/0028-3886.107927 10.1016/j.jocn.2015.11.035 10.1016/j.jns.2015.04.019 10.2176/nmc.52.299 10.1007/s12199-015-0498-7 10.1038/nature13127 10.1038/jhg.2012.105 10.1007/s00381-018-3985-5 10.3389/fneur.2019.00662 10.1186/s12883-020-01884-0 10.1159/000503250 10.1155/2018/6359174 10.1161/JAHA.120.017660 10.1016/j.healun.2019.08.022 10.1016/j.brainres.2014.01.011 10.1016/j.brainres.2014.11.014 10.1016/j.brainres.2015.07.039 10.1038/s41598-018-22064-8 10.1016/j.bbrc.2013.07.004 10.1371/journal.pone.0163561 10.1016/j.scr.2016.11.006 10.1016/j.scr.2016.11.007 10.1186/s12920-018-0385-3 10.1016/j.jstrokecerebrovasdis.2020.105305 10.1016/j.bbrc.2013.08.067 10.1038/srep13191 10.1016/j.brainres.2016.03.009 10.1097/WNR.0000000000000289
Translational Stroke Research; Mertens R, Graupera M et. al.

Sep 17th, 2021 - Moyamoya disease (MMD) is a rare cerebrovascular disease characterized by progressive spontaneous bilateral occlusion of the intracranial internal cerebral arteries (ICA) and their major branches with compensatory capillary collaterals resembling a "puff of smoke" (Japanese: Moyamoya) on cerebral angiography. These pathological alterations of the vessels are called Moyamoya arteriopathy or vasc...

Dose Adjustment Associated Complications of Bone Morphogenetic Protein: A Longitudinal ...
https://doi.org/10.1016/j.wneu.2021.08.142
World Neurosurgery; De Stefano FA, Elarjani T et. al.

Sep 17th, 2021 - Bone morphogenetic protein (BMP) is a growth factor that aids in osteoinduction and promotes bone fusion. There is a lack of literature regarding rhBMP-2 dosage in different spine surgeries. This study aims to investigate the trends in rhBMP-2 dosage and the associated complications in spinal arthrodesis. A retrospective study was conducted investigating spinal arthrodesis using rhBMP-2. Variab...

Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanin...
https://doi.org/10.1097/FTD.0000000000000869
Therapeutic Drug Monitoring; Bayoumy AB, Mulder CJJ et. al.

Sep 16th, 2021 - In inflammatory bowel disease (IBD), conventional thiopurine users cease treatment in 60% of cases within 5 years, mostly because of adverse events or nonresponse. In this study, the authors aimed to investigate the role of 6-thioguanine nucleotide (TGN) measurements, geno/phenotyping of thiopurine S-methyltransferase (TPMT), and their mutual relationship with TG therapy in IBD. An internationa...

Description of a clinical decision support tool with integrated dose calculator for pae...
https://doi.org/10.1007/s00431-021-04261-2 10.1016/S0140-6736(17)31047-4 10.1007/s40264-019-00850-1 10.1001/jama.285.16.2114 10.1007/s00431-015-2542-4 10.1093/jamia/ocw145 10.1007/s00431-019-03556-9 10.1097/PTS.0000000000000646 10.1016/j.clinthera.2006.09.008 10.1007/s40262-015-0298-7 10.1111/bcp.13883 10.1136/archdischild-2013-305212 10.1016/j.zefq.2020.10.004 10.1377/hlthaff.2018.0738 10.1542/peds.2008-2737 10.1016/j.jpeds.2017.08.013 10.1177/1060028014543795 10.1007/s40264-018-0715-6 10.1136/bmj.j5515 10.1016/j.bjps.2013.12.016 10.1542/peds.2021-052047 10.1136/bmj.318.7183.593 10.1542/peds.2005-1287 10.1007/s40267-020-00724-y 10.1007/s40272-020-00386-3 10.1371/journal.pone.0167683 10.1038/s41746-020-0221-y
European Journal of Pediatrics; Higi L, Käser K et. al.

Sep 16th, 2021 - Medication errors, especially dosing errors are a leading cause of preventable harm in paediatric patients. The paediatric patient population is particularly vulnerable to dosing errors due to immaturity of metabolising organs and developmental changes. Moreover, the lack of clinical trial data or suitable drug forms, and the need for weight-based dosing, does not simplify drug dosing in paedia...

Dexamethasone is associated with early deaths in light chain amyloidosis patients with ...
https://doi.org/10.1371/journal.pone.0257189
PloS One; Bézard M, Oghina S et. al.

Sep 16th, 2021 - Cardiac light chain amyloidosis (AL-CA) patients often die within three months of starting chemotherapy. Chemotherapy for non-immunoglobulin M gammopathy with AL-CA frequently includes bortezomib (Bor), cyclophosphamide (Cy), and dexamethasone (D). We previously reported that NT-ProBNP levels can double within 24h of dexamethasone administration, suggesting a deleterious impact on cardiac funct...

Formulation and Cost-Effectiveness of Fluid Gels as an Age-Appropriate Dosage Form for ...
https://doi.org/10.1007/s00455-021-10365-6 10.1177/000348940711601112 10.1016/j.jand.2013.07.037 10.1111/1460-6984.12324 10.1007/s00455-011-9331-7 10.7162/S1809-97772012000400012 10.1164/rccm.200807-1139OC 10.1007/s00455-014-9543-8 10.1093/dote/dox131 10.1136/bmj.310.6988.1179 10.1212/WNL.38.9.1359 10.1007/s40265-014-0297-2 10.1016/0016-5085(90)91149-Z 10.1044/1058-0360(2005/003) 10.1044/sasd11.2.16 10.1007/s00455-014-9578-x 10.1097/01.NAJ.0000390519.83887.02 10.1016/j.pmr.2008.06.002 10.1007/s00455-016-9696-8 10.1186/1475-2891-12-54 10.1044/2020_PERSP-19-00111 10.1007/s11483-018-9523-x 10.1016/j.foodhyd.2014.03.014 10.1016/j.ijpharm.2014.08.044 10.1016/j.foodhyd.2009.03.018 10.1054/clnu.2001.0467 10.2147/CIA.S121905 10.5588/ijtld.18.0775 10.3109/03639045.2016.1151033 10.1503/cmaj.050176 10.1017/S1041610207006047 10.4103/0973-8398.143937 10.1016/j.jsps.2021.07.020 10.1016/S1130-6343(07)75395-3 10.4103/0975-1483.100016 10.1136/bmjgh-2017-000571 10.1136/bmjopen-2015-009586 10.1093/jac/dkw522 10.1080/10837450601168870 10.4103/jpgm.JPGM_420_18 10.4172/2376-0419.1000199kul 10.1201/9781315102856 10.1017/S1041610209991669 10.1002/j.2055-2335.2009.tb00436.x 10.1111/jtxs.12201 10.1002/jps.20477 10.1208/pt050344 10.1016/j.foodhyd.2018.04.024 10.1080/02652040500273704 10.1155/2016/5967907 10.1016/S0268-005X(98)00016-2 10.1177/0148607112471560 10.1038/s41598-019-52269-4 10.2147/PPA.S151603 10.1097/YCO.0b013e3283477b68 10.4102/phcfm.v6i1.604 10.1111/j.1430-9134.1997.00075.x 10.1007/s40258-019-00480-9 10.1007/s00228-017-2225-3 10.1159/000339986
Dysphagia Abd Aziz ZH, Katas H et. al.

Sep 15th, 2021 - Dysphagia is associated with increased dependency and treatment costs, whereby patients resort to extemporaneous compounding that may further increase the number of adverse events and medical errors. In the management of dysphagia, increasing the bolus viscosity of medication such as fluid gels can be practiced. This study aimed to prepare and characterize the fluid gels as well as to estimate ...

DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, ep...
https://doi.org/10.1038/s41467-021-25661-w 10.1101/gr.125567.111 10.1038/301089a0 10.1038/nature10983 10.1038/ncomms11479 10.1038/s41586-019-1007-8 10.1016/j.ajpath.2017.04.022 10.1038/nature11412 10.1038/ng.2442 10.1101/gr.125872.111 10.1038/nature13986 10.1016/j.ccr.2012.11.006 10.1038/nature13458 10.1038/s41588-018-0073-4 10.1038/s41588-020-0645-y 10.1038/s43018-020-0026-6 10.1101/gr.185926.114 10.1186/gb-2012-13-10-r97 10.1186/gb-2012-13-10-r92 10.1093/bioinformatics/btr167 10.1016/j.oraloncology.2012.09.007
Nature Communications; Batra RN, Lifshitz A et. al.

Sep 15th, 2021 - DNA methylation is aberrant in cancer, but the dynamics, regulatory role and clinical implications of such epigenetic changes are still poorly understood. Here, reduced representation bisulfite sequencing (RRBS) profiles of 1538 breast tumors and 244 normal breast tissues from the METABRIC cohort are reported, facilitating detailed analysis of DNA methylation within a rich context of genomic, t...

Health Care Costs in Patients with and without Secondary Hyperparathyroidism in Spain.
https://doi.org/10.1007/s12325-021-01895-4 10.1016/S0140-6736(20)30045-3 10.2471/BLT.17.206441 10.1159/000321382 10.1016/S0140-6736(13)60687-X 10.1038/ki.2011.368 10.1038/sj.ki.5002287 10.1038/ki.2008.64 10.1111/febs.15300 10.1001/jama.2011.308 10.1186/s12882-020-02088-x 10.1681/ASN.2013060632 10.1186/1472-6963-13-248 10.1186/s12882-015-0054-0 10.1517/14728214.2015.1018177 10.1002/pds.2183 10.1159/000228076 10.1186/s12913-016-1671-4 10.1159/000099006 10.1007/s40258-014-0097-6 10.1681/ASN.2014070714 10.1038/kisup.2015.2 10.18203/2320-6012.ijrms20193144 10.1159/000223800 10.1007/s00774-009-0048-8 10.1016/j.kint.2017.04.006
Advances in Therapy; Alonso-Perez E, Forné C et. al.

Sep 15th, 2021 - To analyze the economic burden of secondary hyperparathyroidism (sHPT) in Spain by quantifying differences in costs of pharmacological treatments and associated cardiovascular events (CVE) between renal patients with and without sHPT. We used data collected in the NEFRONA cohort study and obtained treatment and CVE costs from the BOT PLUS database and Hospital Discharge Records in the Spanish H...