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About 1,009,683 results

Levodopa‐induced dyskinesia in Parkinson's disease: clinical features, pathogenesis, prevention and treatment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600052/
Postgraduate Medical Journal;

Jun 5th, 2007 - Levodopa is the most effective drug for treating Parkinson's disease. However, long‐term use of levodopa is often complicated by significantly disabling fluctuations and dyskinesias negating its beneficial effects. Younger age of Parkinson's disease onset, disease severity, and high levodopa dose increase the risk of development of levodopa‐induced dyskinesias (LID). The underlying mechanisms f...

Influence of Vitamin D supplementation on reproductive outcomes of infertile patients: ...
https://doi.org/10.1186/s12958-023-01068-8
Reproductive Biology and Endocrinology : RB&E; Meng X, Zhang J et. al.

Feb 5th, 2023 - Low vitamin D status has been associated with an increased risk for infertility. Recent evidence regarding the efficacy of vitamin D supplementation in improving reproductive outcomes is inconsistent. Therefore, this systematic review was conducted to investigate whether vitamin D supplementation could improve the reproductive outcomes of infertile patients and evaluate how the parameters of vi...

Evaluation of the practice of surgical antibiotic prophylaxis in a Zonal Referral Hospi...
https://doi.org/10.1186/s12893-023-01926-7
BMC Surgery; Mbuyamba HT, Muamba CM et. al.

Feb 5th, 2023 - Surgical Antibiotic Prophylaxis (SAP) is helpful in preventing patients from developing Surgical Site Infections (SSI). In Mbujimayi, the documentation on the practice of SAP is outdated and inadequate. The last study was conducted more than 5 years ago. This study aims at assessing the compliance of the practice of antibiotic prophylaxis in the surgical and obstetrics-gynecology departments of...

The average gonadotrophin dosage per follicle is predictive of ovarian response and cum...
https://doi.org/10.1186/s12905-023-02195-5
BMC Women's Health; Liu S, Ma S et. al.

Feb 5th, 2023 - With the development of assisted reproduction technology (ART), many indicators have been proposed to evaluate ovarian response, and then predict pregnancy outcomes. In general, the predictive values remain limited. To further explore the indicators to evaluate ovarian sensitivity to gonadotrophin (Gn) stimulation more accurately. This retrospective cohort study included 330 women who underwent...

Aluminum-based metal-organic framework nanoparticles as pulmonary vaccine adjuvants.
https://doi.org/10.1186/s12951-023-01782-w
Journal of Nanobiotechnology; Stillman ZS, Decker GE et. al.

Feb 5th, 2023 - The adoption of pulmonary vaccines to advantageously provide superior local mucosal protection against aerosolized pathogens has been faced with numerous logistical and practical challenges. One of these persistent challenges is the lack of effective vaccine adjuvants that could be well tolerated through the inhaled route of administration. Despite its widespread use as a vaccine adjuvant, alum...

Effects of atomoxetine plus a hypnotic on obstructive sleep apnea severity in patients ...
https://doi.org/10.5664/jcsm.10464
Journal of Clinical Sleep Medicine : JCSM : Official Publ... Corser B, Eves E et. al.

Feb 4th, 2023 - Pharmacotherapy for obstructive sleep apnea (OSA) regained consideration after the discovery that atomoxetine and oxybutynin (Ato-Oxy) greatly reduced OSA severity. However, Ato-Oxy reduced the arousal threshold and may therefore be poorly tolerated in patients with OSA and disturbed sleep. As a result, we tested the combination of atomoxetine plus two hypnotics in patients with OSA. The effect...

Statin treatment intensity, discontinuation and long-term outcome in patients with acut...
https://doi.org/10.1097/FJC.0000000000001402
Journal of Cardiovascular Pharmacology; Khedri M, Szummer K et. al.

Feb 4th, 2023 - Statin dosage in patients with acute myocardial infarction (AMI) and concomitant kidney dysfunction is a clinical dilemma. We studied discontinuation during the first year after an AMI and long-term outcome in patients receiving high versus low-moderate intensity statin treatment, in relation to kidney function. For the intention-to-treat analysis (ITT-A) we included all patients admitted to Sw...

Perampanel as Precision Therapy in Rare Genetic Epilepsies.
https://doi.org/10.1111/epi.17530
Epilepsia Nissenkorn A, Kluger G et. al.

Feb 4th, 2023 - Perampanel, an antiseizure drug with AMPA-receptor antagonist properties, may have a targeted effect in genetic epilepsies with overwhelming glutamate receptor activation. Special interest holds epilepsies with loss of GABA inhibition (e.g. SCN1A), overactive excitatory neurons (e.g. SCN2A, SCN8A ), and variants in glutamate receptors (e.g. GRIN2A). We aimed to collect data from a large rare ge...

Retrospective study of ovarian reaction and fertility in women with discordant antimull...
https://doi.org/10.1111/jog.15534
The Journal of Obstetrics and Gynaecology Research; Wang J, Lv Y et. al.

Feb 4th, 2023 - The objective of this study was to examine the predictive ability of follicle-stimulating hormone (FSH)/luteinizing hormone (LH) ratio and antimullerian hormone (AMH) levels in the same cohort when both are inconsistent and to identify which has an excellent ability to predict live birth and ovarian response to in vitro fertilization (IVF). A retrospective cohort study was performed within 6096...

Deposition and dissipation of difenoconazole in pepper and soil and its reduced applica...
https://doi.org/10.1016/j.ecoenv.2023.114591
Ecotoxicology and Environmental Safety; Song J, Zheng Z et. al.

Feb 4th, 2023 - The initial deposition amount, dissipation dynamics, retention rate, and field control efficacy of difenoconazole in pepper-soil system were studied with different application dosages, planting regions and patterns. The initial deposition amount of difenoconazole under the same application dosage showed the following order: fruits < cultivated soils < lower stems < upper stems < lower leaves < ...

Ubrogepant and Rimegepant: Systematic Review, Meta-Analysis, and Meta-Regression of Cli...
https://doi.org/10.1080/14740338.2023.2177270
Expert Opinion on Drug Safety; Dong G, Kjærgaard NA et. al.

Feb 4th, 2023 - This study aimed at providing pooled estimates of the incidence of adverse drug reactions (ADRs) of ubrogepant and rimegepant and to use meta-regression to identify correlations between the occurrence of selected ADRs, socio-demographic, and clinical characteristics from data published in clinical studies. Ovid MEDLINE (up to 03/02/2022) was searched along with the references listed in the revi...

N-Nitrosamine Formation in Pharmaceutical Solid Drug Products: Experimental Observations.
https://doi.org/10.1016/j.xphs.2023.01.027
Journal of Pharmaceutical Sciences; Moser J, Ashworth IW et. al.

Feb 4th, 2023 - The potential presence of N-nitrosamines in medicinal products has become a matter of concern for health authorities and pharmaceutical companies. However, very little information is available in published literature on N-nitrosamine formation within pharmaceutical drug products. In response, experiments were undertaken to test if secondary and tertiary amines present in solid drug products cou...

Safety and Distribution of Opioid Prescribing by U.S. Surgeons.
https://doi.org/10.1097/SLA.0000000000005802
Annals of Surgery; Waljee JF, Gunaseelan V et. al.

Feb 3rd, 2023 - To estimate high-risk prescribing patterns among opioid prescriptions from U.S. surgeons; to characterize the distribution of high-risk prescribing among surgeons. National data on the prevalence of opioid prescribing and high risk opioid prescribing by U.S. surgeons are lacking. Using the IQVIA Prescription Database, which reports dispensing from 92% of U.S. pharmacies, we identified opioid pr...

A Narrative Review Illustrating the Clinical Utility of Electroencephalogram-Guided Ane...
https://doi.org/10.1213/ANE.0000000000006267
Anesthesia and Analgesia; Bong CL, Balanza GA et. al.

Feb 3rd, 2023 - The major therapeutic end points of general anesthesia include hypnosis, amnesia, and immobility. There is a complex relationship between general anesthesia, responsiveness, hemodynamic stability, and reaction to noxious stimuli. This complexity is compounded in pediatric anesthesia, where clinicians manage children from a wide range of ages, developmental stages, and body sizes, with their con...

Effectiveness of cefixime for the treatment of Neisseria gonorrhoeae infection at three...
https://doi.org/10.1097/OLQ.0000000000001742
Sexually Transmitted Diseases; Yang KJ, Kojima N et. al.

Feb 3rd, 2023 - To treat Neisseria (N.) gonorrhoeae infection, the Centers for Disease Control and Prevention recommends a single oral dose of cefixime as an alternative to injectable ceftriaxone. We conducted a systematic review and meta-analysis to describe the effectiveness of cefixime in treating N. gonorrhoeae infection at three different anatomic sites.We searched PubMed and Embase databased to abstract ...

Prehabilitation for Spine Surgery: A Scoping Review.
https://doi.org/10.1002/pmrj.12956
PM & R : the Journal of Injury, Function, and Rehabilitat... Eubanks JE, Carlesso C et. al.

Feb 3rd, 2023 - We aimed to identify and describe the current interventions used in preoperative programs ("prehabilitation") for spine surgery. Knowledge gaps in approaches, feasibility, timing, patient experience, clinical outcomes, and health care costs were explored while describing their potential benefits on physical and psychological outcomes. An electronic search was conducted from January 2004 to Febr...

Evaluation of Policies Limiting Opioid Exposure on Opioid Prescribing and Patient Pain ...
https://doi.org/10.1097/PTS.0000000000001088
Journal of Patient Safety; Rennert L, Howard KA et. al.

Feb 3rd, 2023 - Overprescribing to opioid-naive surgical patients substantially contributes to opioid use disorders, which have become increasingly prevalent. Opioid stewardship programs (OSPs) within healthcare settings provide an avenue for introducing interventions to regulate prescribing. This study examined the association of OSP policies limiting exposure on changes in surgery-related opioid prescription...

Approaches for Optimizing Venous Thromboembolism (VTE) Prevention in Injured Patients: ...
https://doi.org/10.1097/TA.0000000000003854
The Journal of Trauma and Acute Care Surgery; Teichman AL, Cotton BA et. al.

Feb 3rd, 2023 - Venous thromboembolism (VTE) is a major issue in trauma patients. Without prophylaxis, the rate of deep venous thrombosis approaches 60%, and even with chemoprophylaxis may be nearly 30%. Advances in VTE reduction are imperative to reduce the burden of this issue in the trauma population. Novel approaches in VTE prevention may include new medications, dosing regimens, and extending prophylaxis ...

Ten-Day Vonoprazan-Amoxicillin Dual Therapy as a First-Line Treatment of Helicobacter p...
https://doi.org/10.14309/ajg.0000000000002086
The American Journal of Gastroenterology; Qian HS, Li WJ et. al.

Feb 3rd, 2023 - No study has investigated the efficacy and safety of vonoprazan-amoxicillin dual therapy compared with bismuth quadruple therapy (B-quadruple). This study aimed to evaluate the efficacy and safety of 10-day vonoprazan-amoxicillin dual therapy as a first-line treatment of Helicobacter pylori infection compared with B-quadruple and to explore the optimal dosage of amoxicillin in the dual therapy....

Efficacy and safety evaluation of albumin-bound paclitaxel chemotherapy in East Asian p...
https://doi.org/10.1097/CAD.0000000000001459
Anti-cancer Drugs; Liu J, Zhang S et. al.

Feb 3rd, 2023 - Nab-PTX is a special dosage form of antitumor drug that is different from other injections. In order to explore the efficacy and safety of albumin-bound paclitaxel, we developed an analytical method with UPLC-MS/MS to quantify the total and free paclitaxel in plasma, and prospectively evaluate the impact of unbound fraction fu (%) on the prognosis and adverse reactions of patients with gynecolo...