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About 797,764 results

Levodopa‐induced dyskinesia in Parkinson's disease: clinical features, pathogenesis, prevention and treatment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600052/
Postgraduate Medical Journal;

Jun 4th, 2007 - Levodopa is the most effective drug for treating Parkinson's disease. However, long‐term use of levodopa is often complicated by significantly disabling fluctuations and dyskinesias negating its beneficial effects. Younger age of Parkinson's disease onset, disease severity, and high levodopa dose increase the risk of development of levodopa‐induced dyskinesias (LID). The underlying mechanisms f...

Top 20 Research Studies of 2019 for Primary Care Physicians
https://www.aafp.org/afp/2020/0515/p608.html

In 2019, regular surveillance of 110 English-language research journals identified 254 studies that met the criteria to become POEMs (patient-oriented evidence that matters). Physician members of the Canadian Medical Association rated these POEMs for their relevance to patients in their practices. This article summarizes the clinical questions and bottom-line answers from the top 20 POEMs of 20...

Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma.
https://doi.org/10.1056/NEJMoa1805762
The New England Journal of Medicine; Dimopoulos MA, Dytfeld D et. al.

Nov 7th, 2018 - The immunostimulatory monoclonal antibody elotuzumab plus lenalidomide and dexamethasone has been shown to be effective in patients with relapsed or refractory multiple myeloma. The immunomodulatory agent pomalidomide plus dexamethasone has been shown to be effective in patients with multiple myeloma that is refractory to lenalidomide and a proteasome inhibitor. Patients with multiple myeloma t...

Influenza and Tdap Vaccination Coverage Among Pregnant Women - United States, April 2018.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188122
MMWR. Morbidity and Mortality Weekly Report; Kahn KE, Black CL et. al.

Sep 27th, 2018 - Vaccinating pregnant women with influenza and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines can reduce the risk for influenza and pertussis for themselves and their infants. The Advisory Committee on Immunization Practices (ACIP) recommends that all women who are or might be pregnant during the influenza season receive influenza vaccine, which can be adminis...

Effectiveness of a Third Dose of MMR Vaccine for Mumps Outbreak Control.
https://doi.org/10.1056/NEJMoa1703309
The New England Journal of Medicine; Cardemil CV, Dahl RM et. al.

Sep 6th, 2017 - The effect of a third dose of the measles-mumps-rubella (MMR) vaccine in stemming a mumps outbreak is unknown. During an outbreak among vaccinated students at the University of Iowa, health officials implemented a widespread MMR vaccine campaign. We evaluated the effectiveness of a third dose for outbreak control and assessed for waning immunity. Of 20,496 university students who were enrolled ...

Effect of Meropenem-Vaborbactam vs Piperacillin-Tazobactam on Clinical Cure or Improvem...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838656
JAMA Kaye KS, Bhowmick T et. al.

Feb 27th, 2018 - Meropenem-vaborbactam is a combination carbapenem/beta-lactamase inhibitor and a potential treatment for severe drug-resistant gram-negative infections. To evaluate efficacy and adverse events of meropenem-vaborbactam in complicated urinary tract infection (UTI), including acute pyelonephritis. Phase 3, multicenter, multinational, randomized clinical trial (TANGO I) conducted November 2014 to A...

Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a dou...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099122
Lancet (London, England); Francis NA, Cannings-John R et. al.

Aug 28th, 2018 - Children with persistent hearing loss due to otitis media with effusion are commonly managed by surgical intervention. A safe, cheap, and effective medical treatment would enhance treatment options. Underpowered, poor-quality trials have found short-term benefit from oral steroids. We aimed to investigate whether a short course of oral steroids would achieve acceptable hearing in children with ...

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus.
https://doi.org/10.1056/NEJMoa1803760
The New England Journal of Medicine; Fenske W, Refardt J et. al.

Aug 1st, 2018 - The indirect water-deprivation test is the current reference standard for the diagnosis of diabetes insipidus. However, it is technically cumbersome to administer, and the results are often inaccurate. The current study compared the indirect water-deprivation test with direct detection of plasma copeptin, a precursor-derived surrogate of arginine vasopressin. From 2013 to 2017, we recruited 156...

Safety and Side Effects of Rifampin versus Isoniazid in Children.
https://doi.org/10.1056/NEJMoa1714284
The New England Journal of Medicine; Diallo T, Adjobimey M et. al.

Aug 1st, 2018 - The treatment of latent infection with Mycobacterium tuberculosis is important in children because of their vulnerability to life-threatening forms of tuberculosis disease. The current standard treatment - 9 months of isoniazid - has been associated with poor adherence and toxic effects, which have hampered the effectiveness of the drug. In adults, treatment with 4 months of rifampin has been s...

Acquisition of wild-type HIV-1 infection in a patient on pre-exposure prophylaxis with ...
https://doi.org/10.1016/S2352-3018(17)30132-7
The Lancet. HIV; Hoornenborg E, Prins M et. al.

Sep 18th, 2017 - Pre-exposure prophylaxis (PrEP) with emtricitabine and tenofovir disoproxil fumarate is highly effective against acquisition of HIV infection, and only two cases of infection with a multidrug-resistant virus have been reported under adequate long-term adherence, as evidenced by tenofovir diphosphate concentrations in dried blood spots. We report a case of wild-type HIV-1 infection despite consi...

Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervent...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876881
JAMA Berwanger O, Santucci EV et. al.

Mar 11th, 2018 - The effects of loading doses of statins on clinical outcomes in patients with acute coronary syndrome (ACS) and planned invasive management remain uncertain. To determine if periprocedural loading doses of atorvastatin decrease 30-day major adverse cardiovascular events (MACE) in patients with ACS and planned invasive management. Multicenter, double-blind, placebo-controlled, randomized clinica...

Three Rotavirus Outbreaks in the Postvaccine Era - California, 2017.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919604
MMWR. Morbidity and Mortality Weekly Report; Burke RM, Tate JE et. al.

Apr 26th, 2018 - Before the introduction of rotavirus vaccine in 2006, rotavirus was the most common cause of severe diarrhea among U.S. children (1). Currently, two rotavirus vaccines are licensed for use in the United States, both of which have demonstrated good field effectiveness (78%-89%) against moderate to severe rotavirus illness (2), and the use of these vaccines has substantially reduced the prevalenc...

Assessing Optimal Blood Pressure in Patients With Asymptomatic Aortic Valve Stenosis: T...
https://doi.org/10.1161/CIRCULATIONAHA.115.021213
Circulation Nielsen OW, Sajadieh A et. al.

Aug 3rd, 2016 - Evidence for treating hypertension in patients with asymptomatic aortic valve stenosis is scarce. We used data from the SEAS trial (Simvastatin Ezetimibe in Aortic Stenosis) to assess what blood pressure (BP) would be optimal. A total of 1767 patients with asymptomatic aortic stenosis and no manifest atherosclerotic disease were analyzed. Outcomes were all-cause mortality, cardiovascular death,...

Empirical Antibiotic Treatment Does Not Improve Outcomes in Catheter-Associated Urinary...
https://doi.org/10.1093/cid/cix680
Clinical Infectious Diseases : an Official Publication Of... Babich T, Zusman O et. al.

Oct 11th, 2017 - Catheter associated urinary tract infection (CAUTI) is the most common healthcare-associated acquired infection. We aimed to describe the short- and long-term survival of patients with CAUTI and the impact of the empirical antibiotic treatment on survival rates. In this prospective observational study we included consecutive adult patients with a chronic indwelling catheter-associated UTI and s...

Opioid Knowledge and Prescribing Practices Among Obstetrician-Gynecologists.
https://doi.org/10.1097/AOG.0000000000002407
Obstetrics and Gynecology; Madsen AM, Stark LM et. al.

Dec 7th, 2017 - To describe obstetrician-gynecologists' (ob-gyns) knowledge and prescribing practices regarding opioid analgesics. We conducted a cross-sectional survey of a national sample of American College of Obstetricians and Gynecologists Fellows and Junior Fellows who are part of the Collaborative Ambulatory Research Network. We used a sequential mixed-method approach. We collected data on opioid knowle...

Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy: A Sy...
https://doi.org/10.7326/M17-0598
Annals of Internal Medicine; Frank JW, Lovejoy TI et. al.

Jul 17th, 2017 - Expert guidelines recommend reducing or discontinuing long-term opioid therapy (LTOT) when risks outweigh benefits, but evidence on the effect of dose reduction on patient outcomes has not been systematically reviewed. To synthesize studies of the effectiveness of strategies to reduce or discontinue LTOT and patient outcomes after dose reduction among adults prescribed LTOT for chronic pain. ME...

Rheumatoid Arthritis Treatment After Methotrexate: The Durability of Triple Therapy Ver...
https://doi.org/10.1002/acr.23255
Arthritis Care & Research; Peper SM, Lew R et. al.

Apr 7th, 2017 - Although it is common for rheumatologists to initiate biologic agents after failure of methotrexate monotherapy in rheumatoid arthritis (RA), ample data support the initial use of combinations of conventional therapies in this clinical scenario. Our study explores the durability of triple therapy (methotrexate, sulfasalazine, and hydroxychloroquine) versus methotrexate-etanercept in RA. RA pati...

Time to Epinephrine Administration and Survival From Nonshockable Out-of-Hospital Cardi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940513
Circulation Hansen M, Schmicker RH et. al.

Mar 7th, 2018 - Previous studies have demonstrated that earlier epinephrine administration is associated with improved survival from out-of-hospital cardiac arrest (OHCA) with shockable initial rhythms. However, the effect of epinephrine timing on patients with nonshockable initial rhythms is unclear. The objective of this study was to measure the association between time to epinephrine administration and surv...

Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC.
https://doi.org/10.1056/NEJMoa1716948
The New England Journal of Medicine; Socinski MA, Jotte RM et. al.

Jun 4th, 2018 - The cancer-cell-killing property of atezolizumab may be enhanced by the blockade of vascular endothelial growth factor-mediated immunosuppression with bevacizumab. This open-label, phase 3 study evaluated atezolizumab plus bevacizumab plus chemotherapy in patients with metastatic nonsquamous non-small-cell lung cancer (NSCLC) who had not previously received chemotherapy. We randomly assigned pa...

Venetoclax-Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia.
https://doi.org/10.1056/NEJMoa1713976
The New England Journal of Medicine; Seymour JF, Kipps TJ et. al.

Mar 21st, 2018 - Venetoclax inhibits BCL2, an antiapoptotic protein that is pathologically overexpressed and that is central to the survival of chronic lymphocytic leukemia cells. We evaluated the efficacy of venetoclax in combination with rituximab in patients with relapsed or refractory chronic lymphocytic leukemia. In this randomized, open-label, phase 3 trial, we randomly assigned 389 patients to receive ve...