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About 1,005,953 results

Levodopa‐induced dyskinesia in Parkinson's disease: clinical features, pathogenesis, prevention and treatment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600052/
Postgraduate Medical Journal;

Jun 5th, 2007 - Levodopa is the most effective drug for treating Parkinson's disease. However, long‐term use of levodopa is often complicated by significantly disabling fluctuations and dyskinesias negating its beneficial effects. Younger age of Parkinson's disease onset, disease severity, and high levodopa dose increase the risk of development of levodopa‐induced dyskinesias (LID). The underlying mechanisms f...

Variation of the Oxidative Profile in Pregnant Women With and Without Gestational Compl...
https://doi.org/10.1007/s10995-022-03475-6
Maternal and Child Health Journal; de Lucca L, Jantsch LB et. al.

Aug 16th, 2022 - Oxidative stress is closely related to the pathophysiology of gestation, where the placenta is susceptible to oxidative damage, contributing to the onset of gestational complications. Currently, few studies evaluate the use of oxidative markers for prediction of risk of gestational complications. However, there are some reports that suggest these biomarkers as potential prognostic biomarkers. T...

Systemic minoxidil for hair disorders in pediatric patients: a safety and tolerability ...
https://doi.org/10.1111/ijd.16373
International Journal of Dermatology; John JM, Sinclair RD

Aug 15th, 2022 - Topical minoxidil has been used for many years to treat adult alopecia, and there is growing evidence supporting the off-label use of low-dose oral minoxidil (LDOM). However, there is little data on its use in pediatrics, and there are no recommended treatment guidelines. Adverse events are of particular concern in this population. We retrospectively reviewed the medical records of 63 patients ...

PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression.
https://doi.org/10.1038/s41467-022-32543-2
Nature Communications; Lakhia R, Ramalingam H et. al.

Aug 15th, 2022 - Autosomal dominant polycystic kidney disease (ADPKD), among the most common human genetic conditions and a frequent etiology of kidney failure, is primarily caused by heterozygous PKD1 mutations. Kidney cyst formation occurs when PKD1 dosage falls below a critical threshold. However, no framework exists to harness the remaining allele or reverse PKD1 decline. Here, we show that mRNAs produced b...

Dysphagia Risk in Patients Prescribed Rivastigmine: A Systematic Analysis of FDA Advers...
https://doi.org/10.3233/JAD-220583
Journal of Alzheimer's Disease : JAD; Bu K, Patel D et. al.

Aug 15th, 2022 - Dysphagia has been reported as an adverse event for patients receiving rivastigmine for Alzheimer's disease (AD) treatment. The purpose of this study was to determine the association between dysphagia and the usage of rivastigmine by using the pharmacovigilance data from the FDA Adverse Event Reporting System (FAERS). The risk of dysphagia in patients who took rivastigmine was compared with tho...

An expanding horizon of complex injectable products: development and regulatory conside...
https://doi.org/10.1007/s13346-022-01223-5
Drug Delivery and Translational Research; Panchal K, Katke S et. al.

Aug 14th, 2022 - There has been a constant evolution in the pharmaceutical market concerning the new technologies imbibed in delivering drug substances for various indications. This is either market-driven or technology-driven to improve the overall therapeutic efficacy and patients' quality of life. The pharmaceutical industry has experienced rapid growth in the area of complex injectable products because of t...

Prevalence of inappropriate use behaviors of antibiotics and related factors among chin...
https://doi.org/10.1186/s12879-022-07671-1
BMC Infectious Diseases; Yin X, Gong Y et. al.

Aug 14th, 2022 - Inappropriate use of antibiotics could have a profound negative impact on individual and community. This study aimed to assess the prevalence of inappropriate use behaviors of antibiotics in Chinese antibiotic users and explored their related factors. A cross-sectional survey was conducted from July 1, 2018 to September 30, 2018. A structured questionnaire was widely distributed on the online s...

Development of artesunate intelligent prodrug liposomes based on mitochondrial targetin...
https://doi.org/10.1186/s12951-022-01569-5
Journal of Nanobiotechnology; Gu L, Zhang J et. al.

Aug 14th, 2022 - Breast cancer is the leading cause of cancer-related deaths in women and remains a formidable therapeutic challenge. Mitochondria participate in a myriad of essential cellular processes, such as metabolism, and are becoming an ideal target for cancer therapy. Artemisinin and its derivatives have demonstrated multiple activities in the context of various cancers. Mitochondrial autophagy(mitophag...

Juvenile Exposure and Adult Risk Assessment with Single versus Repeated Exposure of Mel...
https://doi.org/10.1016/j.reprotox.2022.08.006
Reproductive Toxicology (Elmsford, N.Y.); Panghal A, Sahu C et. al.

Aug 13th, 2022 - Melphalan significantly contributes to the increase in childhood cancer survival rate. It acts as a gonadotoxic agent and leads to testes damage, dysbalance in gonadal hormones, and impairment in the germ cell proliferation. Therefore, it might be a potent threat to male fertility in individuals who have undergone melphalan treatment during childhood cancer. However, the molecular mechanisms of...

Impact of simulating real microplastics on toluene removal from contaminated soil using...
https://doi.org/10.1016/j.envpol.2022.119895
Environmental Pollution (Barking, Essex : 1987); Li Y, Wei M et. al.

Aug 13th, 2022 - This paper investigated the impacts of various real microplastics (MPs), i.e., polyethylene (PE) and polyethylene terephthalate (PET) with different sizes (1000-2000 and 100-200 μm) and different dosages (0.5 and 5% on a dry weight basis), on the toluene removal during the thermally enhanced air injection treatment. First, microscopic tests were carried out to determine the MPs' microstructure ...

Outcomes of dexmedetomidine versus propofol sedation in critically ill adults requiring...
https://doi.org/10.1016/j.bja.2022.06.020
British Journal of Anaesthesia; Heybati K, Zhou F et. al.

Aug 13th, 2022 - Guidelines have recommended the use of dexmedetomidine or propofol for sedation after cardiac surgery, and propofol monotherapy for other patients. Further outcome data are required for these drugs. This systematic review and meta-analysis was prospectively registered on PROSPERO. The primary outcome was ICU length of stay. Secondary outcomes included duration of mechanical ventilation, ICU del...

Pharmacogenetic testing for NAT2 genotypes in a Tanzanian population across the lifespa...
https://doi.org/10.1016/j.tube.2022.102246
Tuberculosis (Edinburgh, Scotland); Masiphephethu MV, Sariko M et. al.

Aug 13th, 2022 - Despite updated recommendations for weight-based isoniazid dosing in children with drug-susceptible tuberculosis (TB) and higher dose isoniazid in regimens for adults with drug-resistant TB, individual pharmacokinetic variability can lead to sub-target isoniazid exposure. Host pharmacogenetics and isoniazid exposure remain understudied, especially in the East African population. We therefore em...

Kaempferol attenuates viability of ex-vivo cultured post-NACT breast tumor explants thr...
https://doi.org/10.1016/j.prp.2022.154029
Pathology, Research and Practice; Nandi SK, Pradhan A et. al.

Aug 13th, 2022 - Early onset of chemotherapy evasion is a therapeutic challenge. Chemotherapy-induced upregulation of stem cell markers imparts invasiveness and metastatic property to the resident tumor. The efficacy of Kaempferol in attenuating epithelial to mesenchymal transition has earlier been established in the breast cancer cell. In our study population, progression-free survival was observed to be stati...

3D printing of bioactive materials for drug delivery applications.
https://doi.org/10.1080/17425247.2022.2112944
Expert Opinion on Drug Delivery; Nasiri G, Ahmadi S et. al.

Aug 13th, 2022 - Three-dimensional (3D) printing, also known as additive manufacturing (AM), is a modern technique/technology, which makes it possible to construct 3D objects from computer-aided design (CAD) digital models. This technology can be used in the progress of drug delivery systems, where porosity has played important role in attaining an acceptable level of biocompatibility and biodegradability with ...

Activation of Bisulfite with Pyrophosphate-Complexed Mn(III) for Fast Oxidation of Orga...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368537
International Journal of Environmental Research and Publi... Guo Q, Qi X et. al.

Aug 13th, 2022 - Aqueous complexes of Mn(III) ion with ligands exist in various aquatic systems and many stages of water treatment works, while HSO3- is a common reductant in water treatment. This study discloses that their encounter results in a process that oxidizes organic contaminants rapidly. Pyrophosphate (PP, a nonredox active ligand) was used to prepare the Mn(III) solution. An approximate 71% removal o...

Pretreatment with Low-Dose Esketamine for Reduction of Propofol Injection Pain: A Rando...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363235
Pain Research & Management; Fu D, Wang D et. al.

Aug 13th, 2022 - Propofol-induced injection pain is a common adverse effect during the induction of general anesthesia. The purpose of this study is to investigate the effect of low-dose esketamine in preventing propofol injection pain. In this double-blind, randomized, controlled trial, patients scheduled for elective ear surgery under general anesthesia received either normal saline (NS), or 40 mg lidocaine, ...

Effect of low-dose lidocaine on MEPs in patients undergoing intracranial tumor resectio...
https://doi.org/10.1097/MD.0000000000029965
Medicine Liu M, Wang N et. al.

Aug 13th, 2022 - To investigate the effect of low-dose lidocaine on motor evoked potentials (MEPs) in patients undergoing intracranial tumor resection with propofol anesthesia. Forty patients who underwent intracranial tumor resection and required MEP monitoring were selected. They were randomly divided into the lidocaine group (group L, n = 20) and the control group (group C, n = 20) by computer-generated rand...

Concomitant presentation of eosinophilic or oncocytic mucoepidermoid carcinoma, immunog...
https://doi.org/10.1097/MD.0000000000030067
Medicine Chhabra N, Cebak JE et. al.

Aug 13th, 2022 - Immunoglobulin (Ig) G4-related disease (IgG4-RD) reportedly has a strong relationship with adult-onset asthma and periocular xanthogranuloma (AAPOX) and may be linked to sclerosing mucoepidermoid carcinoma (MEC). We present a rare case of IgG4-RD and AAPOX occurring in a patient with resected eosinophilic or oncocytic MEC. A 52-year-old woman was referred to our rheumatology clinic in 2020 to b...

Comparative Effectiveness of Opioid Tapering or Abrupt Discontinuation vs No Dosage Cha...
https://doi.org/10.1001/jamanetworkopen.2022.26523
JAMA Network Open; Larochelle MR, Lodi S et. al.

Aug 13th, 2022 - Opioid dosage tapering has emerged as a strategy to reduce harms associated with long-term opioid therapy; however, evidence supporting this approach is limited. To identify the association of opioid tapering or abrupt discontinuation with opioid overdose and suicide events among patients receiving stable long-term opioid therapy without evidence of opioid misuse. This comparative effectiveness...

Effect of Lipid Vehicles on Solubility, Stability, and Topical Permeation of Delta-9-Te...
https://doi.org/10.1208/s12249-022-02385-8
AAPS PharmSciTech; Shankar VK, Shettar A et. al.

Aug 13th, 2022 - Delta-9-tetrahydrocannabinol (THC) is one of the most effective antinociceptive agents used in the treatment of peripheral neuropathy. THC is highly lipophilic and susceptible to thermal and oxidative degradation. Identifying appropriate solvents in which THC is stable as well as adequately solubilized is crucial in developing topical dosage forms. Lipid solvent systems are of utmost utility an...