×
About 345,418 results

Zebrafish (Danio rerio) larva as an in vivo vertebrate model to study renal function.
https://doi.org/10.1152/ajprenal.00375.2021
American Journal of Physiology. Renal Physiology; Bolten JS, Pratsinis A et. al.

Jan 18th, 2022 - There is an increasing interest in using the zebrafish (Danio rerio) larva as a vertebrate screening model to study drug disposition. Since the pronephric kidney of zebrafish larvae shares high similarity with the anatomy of nephrons in higher vertebrates including humans, we explored in the present study whether 3 to 4 days old zebrafish larvae have a fully functional pronephron. Intravenous i...

Analysis of the Performance of Daily Surgery Score (CASUS) in Patients with Mixed Racia...
https://doi.org/10.1053/j.jvca.2021.11.041
Journal of Cardiothoracic and Vascular Anesthesia; Sudarsanan S, Pattath AR et. al.

Jan 17th, 2022 - The aim was to look at the Cardiac Surgery Score (CASUS) assessment after cardiac surgery, and compare it with the intensive care unit (ICU) mortality and morbidity, in a racially diverse group of patients, in a single center. Clinical retrospective study analyzing data from 319 patients over a 1-year duration. Cardiothoracic intensive care unit (CTICU) of a tertiary care center. All patients w...

Daldinans D‒G, new isoindolinone antioxidants isolated from the ascomycete Daldinia con...
https://doi.org/10.1007/s11418-021-01592-0 10.2174/157339911794940729 10.1016/j.freeradbiomed.2005.05.003 10.1248/cpb.42.2397 10.4489/MYCO.2006.34.1.038 10.1002/hlca.200690004 10.1016/S0031-9422(02)00264-9 10.1021/np049793j 10.1021/np020301h 10.1021/acs.jnatprod.7b00976 10.1038/ja.2011.109 10.1016/j.bmc.2009.04.064 10.1038/ja.2015.117 10.1038/ja.2015.83 10.1016/j.bmcl.2010.07.093 10.4489/MYCO.2008.36.1.055 10.1016/j.bmcl.2007.10.072 10.1016/S0891-5849(98)00315-3
Journal of Natural Medicines; Ki DW, Kim SE et. al.

Jan 17th, 2022 - Four new isoindolinone derivatives, daldinans D‒G (3‒6), together with two known compounds, daldinans A and B (1 and 2), were isolated from the stroma of the ascomycete Daldinia concentrica. Chemical structures of the isolated compounds were determined by spectroscopic methods. All of these compounds exhibited antioxidant activities with IC50 values of 3.21 to 39.67 µM in the 2,2'-azinobis(3-et...

The implication of parabens in cosmetics and cosmeceuticals: advantages and limitations.
https://doi.org/10.1111/jocd.14775
Journal of Cosmetic Dermatology; Al-Halaseh LK, Al-Adaileh S et. al.

Jan 16th, 2022 - Cosmetics, cosmeceuticals, and variable healthcare products used parabens, among other excipients, for their preservative and antimicrobial activities. Paraben derivatives exhibit distinguished physiochemical properties that enable them to be compatible with the formulation of cosmetic agents in different dosage forms. In addition to their potency and efficacy, parabens are economically efficie...

Overexpression of OsMYBR22/OsRVE1 transcription factor simultaneously enhances chloropl...
https://doi.org/10.1016/j.ymben.2021.12.014
Metabolic Engineering; Jeong YS, Choi H et. al.

Jan 16th, 2022 - The OsMYBR22 (same to OsRVE1), an R1type-MYB transcription factor belonging to the rice CCA1-like family, was upregulated under blue light condition, which enhanced the chlorophyll and carotenoid accumulation. The overexpression of OsMYBR22 in rice (Oryza sativa, L) led to everlasting green seeds and leaves of a darker green. Transgene expression patterns showed more concordance with chlorophyl...

Synthesis of (Thio)Furan-Fused Phospholes via Phosphonation Cyclization and a Base-Prom...
https://doi.org/10.1021/acs.joc.1c02577
The Journal of Organic Chemistry; Li C, Huang H et. al.

Jan 15th, 2022 - Herein, we developed a novel strategy for synthesizing ladder (thio)furan-fused phospholes via intermolecular phosphonation cyclization and a base-promoted phospha-Friedel-Crafts reaction under mild conditions. The starting substrates are readily available phosphinic acids and easy-to-handle alkynes. The details of the reaction mechanism were further rationalized using theoretical calculations....

Chemical Space Expansion of Flavonoids: Induction of Mitotic Inhibition by Replacing Ri...
https://doi.org/10.1021/acs.jnatprod.1c00867
Journal of Natural Products; Hirazawa S, Saito Y et. al.

Jan 15th, 2022 - Natural products, which are enzymatically biosynthesized, have a broad range of biological activities. In particular, many flavonoids are known to contribute to human health with low toxicity. We previously reported that novel benzo[b]thiophenyl (BT) flavones with a 10π-electron BT ring B replacing the usual 6π-electron phenyl ring showed potent antiproliferative activity against human tumor ce...

Specific Noncovalent Association of Truncated exo-Functionalized Triangular Homochiral ...
https://doi.org/10.1021/acs.joc.1c02238
The Journal of Organic Chemistry; Janiak A, Gajewy J et. al.

Jan 15th, 2022 - Chiral isotrianglimines were synthesized by the [3 + 3] cyclocondensation of (R,R)-1,2-diaminocyclohexane with C5-substituted isophthalaldehyde derivatives. The substituent's steric and electronic demands and the guest molecules' nature have affected the conformation of individual macrocycles and their propensity to form supramolecular architectures. In the crystal, the formation of a honeycomb...

Synthesis of (±)-Emtricitabine and (±)-Lamivudine by Chlorotrimethylsilane-Sodium Iodid...
https://doi.org/10.1021/acs.joc.1c02772
The Journal of Organic Chemistry; Mear SJ, Nguyen LV et. al.

Jan 15th, 2022 - By simple combination of water and sodium iodide (NaI) with chlorotrimethylsilane (TMSCl), promotion of a Vorbrüggen glycosylation en route to essential HIV drugs emtricitabine (FTC) and lamivudine (3TC) is achieved. TMSCl-NaI in wet solvent (0.1 M water) activates a 1,3-oxathiolanyl acetate donor for N-glycosylation of silylated cytosine derivatives, leading to cis-oxathiolane products with up...

Severity of anabolic steroid dependence, executive function, and personality traits in ...
https://doi.org/10.1016/j.drugalcdep.2022.109275
Drug and Alcohol Dependence; Scarth M, Havnes IA et. al.

Jan 15th, 2022 - Anabolic androgenic steroids (AAS), including testosterone and synthetic derivatives, are typically used to increase muscle mass. Many users develop a dependence on these substances, contributing to worsened physical and mental health outcomes. Aspects of personality and executive dysfunction may represent underlying vulnerabilities for developing dependence. To identify levels of AAS dependenc...

Design, Synthesis, Molecular Docking and Biological Studies of New Heterocyclic Compoun...
https://doi.org/10.2174/1871520622666220112104320
Anti-cancer Agents in Medicinal Chemistry; Mohareb RM, Bagato NMA et. al.

Jan 14th, 2022 - Cancer is a disease illustrated by a shift in the controlled mechanisms that control both cell proliferation and differentiation. It is regarded as a prime health problem worldwide, leading cause of human death-rate exceeded only by cardiovascular diseases. Many reported work was concerned with the discovery of new antitumor compounds this encourage us to synthesis new anticancer agents. In thi...

The Change of Oxidative Stress in Maternal Blood During Pregnancy.
https://doi.org/10.1007/s43032-022-00848-8 10.1007/s00404-002-0302-y 10.11613/BM.2009.017 10.1038/bmt.2012.244 10.1016/j.placenta.2009.01.003 10.1016/j.bpobgyn.2010.10.016 10.1111/j.1447-0756.2010.01303.x 10.3390/ijms19051496 10.1038/hr.2011.200 10.1038/jhh.2012.58 10.1016/j.ajog.2016.12.174 10.1038/hr.2013.131 10.1111/j.1447-0756.2009.01063.x 10.3389/fimmu.2014.00567 10.1038/hr.2012.208
Reproductive Sciences (Thousand Oaks, Calif.); Mika F, Norikazu W et. al.

Jan 14th, 2022 - Oxidative stress (OS) is a state in which the oxidative capacity exceeds the antioxidant capacity in vivo. OS is associated with various perinatal diseases. There have been few reports about OS during pregnancy, such as OS changes that occur during gestation, normal maternal OS dynamics, and OS levels in umbilical cord blood. We here examined the oxidative and antioxidant capacity in maternal b...

Itaconate and derivatives reduce interferon responses and inflammation in influenza A v...
https://doi.org/10.1371/journal.ppat.1010219
PLoS Pathogens; Sohail A, Iqbal AA et. al.

Jan 14th, 2022 - Excessive inflammation is a major cause of morbidity and mortality in many viral infections including influenza. Therefore, there is a need for therapeutic interventions that dampen and redirect inflammatory responses and, ideally, exert antiviral effects. Itaconate is an immunomodulatory metabolite which also reprograms cell metabolism and inflammatory responses when applied exogenously. We ev...

Synthesis and Biological Evaluation of Substituted Thiophene Derivatives.
https://doi.org/10.1007/978-3-030-78787-5_23 10.1007/s00044-011-9862-3 10.1016/S0223-5234(96)80005-5 10.1016/j.bmc.2010.05.034 10.1016/j.bmcl.2011.10.056 10.1016/j.ejmech.2011.11.004 10.2298/JSC0607713C
Advances in Experimental Medicine and Biology; Palupanuri N, Konda S et. al.

Jan 14th, 2022 - A novel series of pyrazolines were synthesized by cycloaddition of various chalcones (prepared by a Claisen-Schmidt condensation of 3-acetyl-2,5-dimethyl thiophene and various aromatic aldehydes) with the phenyl hydrazines in the presence of pyridine and subjected to molecular property prediction by Molinspiration, MolSoft, and Osiris software. The structures of new compounds were established b...

Designing and Screening of New Schiff Bases of Isatins for Antibacterial Activity by In...
https://doi.org/10.1007/978-3-030-78787-5_30 10.1002/prac.18410220148 10.1002/prac.18420250155 10.1074/jbc.275.1.135 10.4314/tjpr.v17i11.18 10.3389/fchem.2017.00107 10.5937/savteh1502049T
Advances in Experimental Medicine and Biology; Swathi K, Meghana B et. al.

Jan 14th, 2022 - Isatin or tribulin is an indole derivative; the compound was first obtained by Erdmann [1] and Laurent [2] and Erdmann in 1841 as a product from the oxidation of indigo dye by nitric acid and chromic acids. The compound is found in many plants, such as Isatis tinctoria, Calanthe discolor, and Couroupita guianensis. Schiff bases of isatin are investigated for their pharmaceutical properties. Isa...

Design, Characterization, and Docking Studies of Some Novel Isatin Derivatives for Anti...
https://doi.org/10.1007/978-3-030-78787-5_44 10.1002/prac.18410220148 10.1002/prac.18420250155 10.1002/anie.198801131 10.3390/M437 10.1248/cpb.46.886 10.1016/S0040-4020(01)89832-X 10.1016/S0304-4165(89)80048-0 10.1016/0378-4347(91)80585-Z 10.1016/S0040-4020(01)96609-8 10.1039/c39770000535 10.1016/0040-4020(80)80221-3 10.1055/s-2006-959766 10.3329/bjp.v13i1.33625
Advances in Experimental Medicine and Biology; Swathi K, Sowjanya K et. al.

Jan 14th, 2022 - Isatin (indoline-2,3-dione) derivatives are derived from plant origin indole derivatives by the Sandmeyer method and characterized by IR, NMR, and mass spectrometric method. Molinspiration is used to calculate the molecular properties of all the synthesized compounds and to generate bioactivity scores (GPCR ligand, ion channel inhibitor, kinase inhibitor, nuclear receptor ligand, protease inhib...

Synthesis, Anti-inflammatory Activity, and In Silico Studies of Some New 3-({P-Dimethyl...
https://doi.org/10.1007/978-3-030-78787-5_43 10.1002/prac.18410240101 10.1002/prac.18420250155 10.1002/anie.198811133 10.1192/bjp.109.462.687 10.1016/S0014-827X(99)00075-0 10.1016/S0968-0896(02)00439-X 10.1016/j.antiviral.2006.02.010 10.1002/ardp.201100055 10.1016/j.ejmech.2009.12.035 10.1080/14756366.2017.1279155 10.5530/ijper.52.1.13 10.1016/j.bmcl.2004.05.025 10.5897/AJPP2014.4261 10.1016/j.ejmech.2008.02.034 10.17344/acsi.2017.3575 10.1021/jm051256o 10.1155/2015/826489 10.1016/j.molstruc.2017.09.092
Advances in Experimental Medicine and Biology; Swathi K, Chaitanya M et. al.

Jan 14th, 2022 - Ten novel isatin Schiff base analogs have been designed using a combination of isatin, hydrazine hydrate, and para-dimethylaminobenzaldehyde. Molecular docking studies have been performed to study the binding interactions of the designed compounds with COX-2 protein as a target (PDB code: 3LN1). The ten novel 3-({p-dimethylamino}benzylidenehydrazinylidene)-1,3-dihydro-2H-indole-2-one derivative...

Synthesis, In Silico Studies, and Biological Evaluation of 1,3,4-Oxadiazino Indole Deri...
https://doi.org/10.1007/978-3-030-78787-5_29 10.4103/0975-9476.172384 10.1007/s00228-013-1636-z 10.4103/0975-7406.80765 10.4103/1687-4315.161287 10.1016/S0378-8741(96)01455-9
Advances in Experimental Medicine and Biology; Pavani K, Swathi K

Jan 14th, 2022 - New series of substituted 2-[4-pyridyl](1,3,4)oxadiazino(5,6-b)indole derivatives were synthesized and evaluated for in silico studies. Based on in silico studies, the selected compounds were synthesized and evaluated for their antidepressant activity by forced swim test. Among these compounds, compound IVD was found to be most potent antidepressant-like activity and significantly reduced the d...

Synthesis of new pyrazole hybrids as potential anticancer agents with xanthine oxidase ...
https://doi.org/10.2174/1871520622666220110162651
Anti-cancer Agents in Medicinal Chemistry; Alsayari A, Asiri YI et. al.

Jan 13th, 2022 - Synthesis of hybrid molecules containing pyrazole and aryldiazenyl/arylhydrazono fragments with promising anticancer activity. The clinical effectiveness of anticancer drugs is limited by their adverse side effects and patient resistance. Therefore, the development of safer classes of drugs through rational drug design is an imperative. Considering the anticancer potential of the pyrazole moiet...

In silico predictions of absorption of MDI substances after dermal or inhalation exposu...
https://doi.org/10.1016/j.yrtph.2022.105117
Regulatory Toxicology and Pharmacology : RTP; Bartels M, van Osdol W et. al.

Jan 13th, 2022 - Methylenediphenyl diisocyanate (MDI) substances used polyurethane production can range from their simplest monomeric forms (e.g., 4,4'-MDI) to mixtures of the monomers with various homologues, homopolymer, and prepolymer derivatives. The relative dermal or inhalation absorption of 39 constituents of these substances in human were predicted using the GastroPlus® program. Predicted dermal uptake ...