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About 268,958 results

Niacin: Fact Sheet for Health Professionals
https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/
National Institutes of Health (NIH)

Niacin (also known as vitamin B3) is one of the water-soluble B vitamins. Niacin is the generic name for nicotinic acid (pyridine-3-carboxylic acid), nicotinamide (niacinamide or pyridine-3-carboxamide), and related derivatives, such as nicotinamide riboside [1-3]. Niacin is naturally present in many foods, added to some food products, and available as a dietary supplement.

Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma.
https://doi.org/10.1056/NEJMoa1805762
The New England Journal of Medicine; Dimopoulos MA, Dytfeld D et. al.

Nov 7th, 2018 - The immunostimulatory monoclonal antibody elotuzumab plus lenalidomide and dexamethasone has been shown to be effective in patients with relapsed or refractory multiple myeloma. The immunomodulatory agent pomalidomide plus dexamethasone has been shown to be effective in patients with multiple myeloma that is refractory to lenalidomide and a proteasome inhibitor. Patients with multiple myeloma t...

Effect of Meropenem-Vaborbactam vs Piperacillin-Tazobactam on Clinical Cure or Improvem...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838656
JAMA Kaye KS, Bhowmick T et. al.

Feb 27th, 2018 - Meropenem-vaborbactam is a combination carbapenem/beta-lactamase inhibitor and a potential treatment for severe drug-resistant gram-negative infections. To evaluate efficacy and adverse events of meropenem-vaborbactam in complicated urinary tract infection (UTI), including acute pyelonephritis. Phase 3, multicenter, multinational, randomized clinical trial (TANGO I) conducted November 2014 to A...

Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally ad...
https://doi.org/10.1016/S1470-2045(17)30111-0
The Lancet. Oncology; Thuss-Patience PC, Shah MA et. al.

Mar 27th, 2017 - Although trastuzumab plus chemotherapy is the standard of care for first-line treatment of HER2-positive advanced gastric cancer, there is no established therapy in the second-line setting. In GATSBY, we examined the efficacy and tolerability of trastuzumab emtansine in patients previously treated for HER2-positive advanced gastric cancer (unresectable, locally advanced, or metastatic gastric c...

Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or ...
https://doi.org/10.1016/S0140-6736(17)33297-X
Lancet (London, England); Powles T, Durán I et. al.

Dec 22nd, 2017 - Few options exist for patients with locally advanced or metastatic urothelial carcinoma after progression with platinum-based chemotherapy. We aimed to assess the safety and efficacy of atezolizumab (anti-programmed death-ligand 1 [PD-L1]) versus chemotherapy in this patient population. We conducted this multicentre, open-label, phase 3 randomised controlled trial (IMvigor211) at 217 academic m...

Acquisition of wild-type HIV-1 infection in a patient on pre-exposure prophylaxis with ...
https://doi.org/10.1016/S2352-3018(17)30132-7
The Lancet. HIV; Hoornenborg E, Prins M et. al.

Sep 18th, 2017 - Pre-exposure prophylaxis (PrEP) with emtricitabine and tenofovir disoproxil fumarate is highly effective against acquisition of HIV infection, and only two cases of infection with a multidrug-resistant virus have been reported under adequate long-term adherence, as evidenced by tenofovir diphosphate concentrations in dried blood spots. We report a case of wild-type HIV-1 infection despite consi...

Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation.
https://doi.org/10.1056/NEJMoa1708454
The New England Journal of Medicine; Cannon CP, Bhatt DL et. al.

Aug 28th, 2017 - Triple antithrombotic therapy with warfarin plus two antiplatelet agents is the standard of care after percutaneous coronary intervention (PCI) for patients with atrial fibrillation, but this therapy is associated with a high risk of bleeding. In this multicenter trial, we randomly assigned 2725 patients with atrial fibrillation who had undergone PCI to triple therapy with warfarin plus a P2Y12...

Management of gastrointestinal angiodysplastic lesions (GIADs): a systematic review and...
https://doi.org/10.1038/ajg.2014.19
The American Journal of Gastroenterology; Jackson CS, Gerson LB

Mar 19th, 2014 - Gastrointestinal angiodysplastic lesions (GIADs) are defined as pathologically dilated communications between veins and capillaries. The objective of this systematic review and meta-analysis was to determine the efficacy of available treatment modalities for GIADs. We identified eligible studies by searching through PubMed, SCOPUS, and Cochrane central register of controlled trials. We searched...

Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systema...
https://doi.org/10.1001/jama.2014.3628
JAMA Jonas DE, Amick HR et. al.

May 15th, 2014 - Alcohol use disorders cause substantial morbidity and early mortality yet remain greatly undertreated. Medications are considerably underused. To conduct a systematic review and meta-analysis of the benefits and harms of medications (US FDA-approved and others) for adults with alcohol use disorders. PubMed, Cochrane Library, PsycINFO, CINAHL, EMBASE, FDA website, and clinical trials registries ...

Sofosbuvir and ribavirin in HCV genotypes 2 and 3.
https://doi.org/10.1056/NEJMoa1316145
The New England Journal of Medicine; Zeuzem S, Dusheiko GM et. al.

May 5th, 2014 - In clinical trials, treatment with a combination of the nucleotide polymerase inhibitor sofosbuvir and the antiviral drug ribavirin was associated with high response rates among patients with hepatitis C virus (HCV) genotype 2 infection, with lower response rates among patients with HCV genotype 3 infection. We conducted a study involving patients with HCV genotype 2 or 3 infection, some of who...

Syphilis predicts HIV incidence among men and transgender women who have sex with men i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166980
Clinical Infectious Diseases : an Official Publication Of... Solomon MM, Mayer KH et. al.

Jun 14th, 2014 - Syphilis infection may potentiate transmission of human immunodeficiency virus (HIV). We sought to determine the extent to which HIV acquisition was associated with syphilis infection within an HIV preexposure prophylaxis (PrEP) trial and whether emtricitabine/tenofovir (FTC/TDF) modified that association. The Preexposure Prophylaxis Initiative (iPrEx) study randomly assigned 2499 HIV-seronegat...

Daily oral tenofovir and emtricitabine-tenofovir preexposure prophylaxis reduces herpes...
https://doi.org/10.7326/M13-2471
Annals of Internal Medicine; Celum C, Morrow RA et. al.

Jun 30th, 2014 - Daily oral preexposure prophylaxis (PrEP) using the antiretroviral tenofovir disoproxil fumarate (TDF) alone or in combination with emtricitabine (FTC-TDF) reduces the risk for HIV-1 acquisition. Tenofovir has in vitro activity against herpes simplex virus type 2 (HSV-2). To assess the efficacy of daily oral PrEP with tenofovir and FTC-TDF in the prevention of HSV-2 acquisition. Subgroup analys...

Guidelines of care for the management of atopic dermatitis: section 3. Management and t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410179
Journal of the American Academy of Dermatology; Sidbury R, Davis DM et. al.

May 12th, 2014 - Atopic dermatitis is a chronic, pruritic inflammatory dermatosis that affects up to 25% of children and 2% to 3% of adults. This guideline addresses important clinical questions that arise in atopic dermatitis management and care, providing recommendations based on the available evidence. In this third of 4 sections, treatment of atopic dermatitis with phototherapy and systemic immunomodulators...

Once-weekly dalbavancin versus daily conventional therapy for skin infection.
https://doi.org/10.1056/NEJMoa1310480
The New England Journal of Medicine; Boucher HW, Wilcox M et. al.

Jun 4th, 2014 - Dalbavancin, a lipoglycopeptide antibiotic agent that is active against gram-positive pathogens, has a long plasma half-life, allowing for once-weekly dosing. DISCOVER 1 and DISCOVER 2 were identically designed noninferiority trials of dalbavancin for the treatment of acute bacterial skin and skin-structure infection. We randomly assigned patients to receive dalbavancin intravenously on days 1 ...

Enzalutamide in metastatic prostate cancer before chemotherapy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418931
The New England Journal of Medicine; Beer TM, Armstrong AJ et. al.

Jun 2nd, 2014 - Enzalutamide is an oral androgen-receptor inhibitor that prolongs survival in men with metastatic castration-resistant prostate cancer in whom the disease has progressed after chemotherapy. New treatment options are needed for patients with metastatic prostate cancer who have not received chemotherapy, in whom the disease has progressed despite androgen-deprivation therapy. In this double-blind...

Testosterone dose-response relationships in hysterectomized women with or without oopho...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701202
Menopause (New York, N.Y.); Huang G, Basaria S et. al.

Nov 27th, 2013 - This study aims to determine the dose-dependent effects of testosterone on sexual function, body composition, muscle performance, and physical function in hysterectomized women with or without oophorectomy. Seventy-one postmenopausal women who previously underwent hysterectomy with or without oophorectomy and had total testosterone levels less than 31 ng/dL or free testosterone levels less than...

Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients wit...
https://doi.org/10.1016/S0140-6736(14)60976-4
Lancet (London, England); Dungan KM, Povedano ST et. al.

Jul 15th, 2014 - Dulaglutide and liraglutide, both glucagon-like peptide-1 (GLP-1) receptor agonists, improve glycaemic control and reduce weight in patients with type 2 diabetes. In a head-to-head trial, we compared the safety and efficacy of once-weekly dulaglutide with that of once-daily liraglutide in metformin-treated patients with uncontrolled type 2 diabetes. We did a phase 3, randomised, open-label, par...

Lanreotide in metastatic enteropancreatic neuroendocrine tumors.
https://doi.org/10.1056/NEJMoa1316158
The New England Journal of Medicine; Caplin ME, Pavel M et. al.

Jul 11th, 2014 - Somatostatin analogues are commonly used to treat symptoms associated with hormone hypersecretion in neuroendocrine tumors; however, data on their antitumor effects are limited. We conducted a randomized, double-blind, placebo-controlled, multinational study of the somatostatin analogue lanreotide in patients with advanced, well-differentiated or moderately differentiated, nonfunctioning, somat...

Two decades of using the combination of tetracycline derivatives and niacinamide as ste...
https://doi.org/10.1016/j.jaad.2014.04.040
Journal of the American Academy of Dermatology; McCarty M, Fivenson D

Jun 7th, 2014 - The twin goals of long-term disease control and minimizing toxicities related to immunosuppression necessitate efforts to find effective steroid-sparing agents in the management of patients with autoimmune bullous diseases. Pemphigus especially requires a long view, because the disease can persist throughout a patient's lifetime, yet few clinical trial reports exist to guide the practitioner. W...

Vitamin D and mortality: meta-analysis of individual participant data from a large cons...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061380
BMJ (Clinical Research Ed.); Schöttker B, Jorde R et. al.

Jun 18th, 2014 - To investigate the association between serum 25-hydroxyvitamin D concentrations (25(OH)D) and mortality in a large consortium of cohort studies paying particular attention to potential age, sex, season, and country differences. Meta-analysis of individual participant data of eight prospective cohort studies from Europe and the US. General population. 26,018 men and women aged 50-79 years. All-c...