Mar 29th, 2023 - Practice Essentials In 1981, Kaposi sarcoma seen in AIDS (KS-AIDS) in America was identified in 3 reports of Kaposi sarcoma as an original defining element of what later became known as AIDS (plus an important editorial and a Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report bulletin). These original descriptions were by Borkovic and Schwartz in San Francisco, Fri...

Mar 29th, 2023 - Practice Essentials In 1981, Kaposi sarcoma seen in AIDS (KS-AIDS) in America was identified in 3 reports of Kaposi sarcoma as an original defining element of what later became known as AIDS (plus an important editorial and a Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report bulletin). These original descriptions were by Borkovic and Schwartz in San Francisco, Fri...

Mar 29th, 2023 - Practice Essentials In 1981, Kaposi sarcoma seen in AIDS (KS-AIDS) in America was identified in 3 reports of Kaposi sarcoma as an original defining element of what later became known as AIDS (plus an important editorial and a Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report bulletin). These original descriptions were by Borkovic and Schwartz in San Francisco, Fri...

Mar 27th, 2023 - A prospective novel technique has been developed for green synthesis of iridium nanoparticles of rod shapes for the first time with simultaneous formation of keto-derivative oxidation product with a yield of 98.3 %. This takes place by reduction of hexacholoroiridate (IV) by using sustainable pectin as a powerful reducing agent biomacromolecule in acidic media. The formation of nanoparticles (I...

Mar 27th, 2023 - It has been reported that death related to cardiovascular disease has increased up to 12.5% just in the past decade alone with various factors playing a role. In 2015 alone it has been estimated that there were 422.7 million cases of CVD with 17.9 million deaths. Various therapies have been discovered to control and treat CVDs and their complications including reperfusion therapies and pharmaco...

Mar 27th, 2023 - Anthracyclines have contributed significantly to remarkable improvements in overall survival and are regarded as the most effective cytostatic drug for cancer treatment in various malignancies. However, anthracyclines are a significant cause of acute and chronic cardiotoxicity in cancer patients, and long-term cardiotoxicity can lead to death in about one-third of patients. Several molecular pa...

Mar 26th, 2023 - We developed a microplate enzyme immunoassay (EIA) to measure dehydroepiandrosterone sulfate (DHEAS) in the blood, urine, and feces of Japanese macaques and evaluated the relationship between serum DHEAS and excreta DHEAS. Our DHEAS EIA using heterological DHEA derivatives conjugated with enzyme was highly sensitive, and linearities and recoveries for all matrices of Japanese macaques were reli...

Mar 26th, 2023 - A stable, reusable and cost-effective covalent organic framework (COF) with medium polarity was successfully decorated on Fe3O4. The Fe3O4@COF contained tailor-made polarity and pore size that fitted well with bisphenols and their derivatives (BPs). When coupling magnetic solid-phase extraction (MSPE) with high-performance liquid chromatography (HPLC) detection, the Fe3O4@COF features efficient...

Mar 26th, 2023 - Functionalized drug delivery systems have been investigated to improve the targetability and intracellular translocation of therapeutic drugs. We developed high functionality and quality lipids that met unique requirements, focusing on the quality of functional lipids for the preparation of targeted nanoparticles using microfluidic devices. While searching for a lipid with high solubility and d...

Mar 25th, 2023 - In this work, chitin, as a biobased polymer, is used as a precursor to obtain a phosphorylated derivatives. The influence of the different degree of phosphorylation in chitin on pyrolysis pattern was investigated. In order to understand the pyrolysis mechanism and the potential application of phosphorylated chitins, the samples were pyrolyzed at different temperatures and analyzed by FTIR, SEM,...

Mar 25th, 2023 - G protein-coupled receptors (GPCRs) regulate cellular signaling pathways by coupling to two classes of transducers: heterotrimeric G proteins and β-arrestins. [Sarcosine1Ile4Ile8]-angiotensin II (SII), an analog of the endogenous ligand angiotensin II (AngII) for the angiotensin II type 1 receptor (AT1R), fails to activate G protein in physiologically relevant models. Despite this, SII and seve...

Mar 25th, 2023 - Aminoacyl-tRNA synthetases are crucial enzymes for cellular protein metabolism and have been considered as an attractive target for development of new antimicrobials. In the current study, seryl tRNA synthetase of Leishmania donovani (LdSerRS) and its mutants were purified and characterized through biochemical and structural methods. Purified LdSerRS was found to be enzymatically active and exh...

Mar 25th, 2023 - Poor solubility and dissolution rate of drugs are largely responsible for erratic drug absorption and limited oral bioavailability. Etodolac (ETO) is a non-steroidal anti-inflammatory drug (NSAID) that is classified as BCS class II (dissolution rate-dependent absorption). ETO has high safety and efficacy in pain relief and control of inflammation. ETO is commercially available as (400-600 mg) t...

Mar 25th, 2023 - The spine is the most common site of bone metastases. Many cancer patients will ultimately develop spinal metastatic disease with symptomatic epidural spinal cord compression. At present, the main treatment for cervical spine tumors is surgical resection combined with postoperative radiotherapy. Implant materials for cervical spine anterior column reconstruction need to meet amounts of differen...

Mar 24th, 2023 - A one-pot catalytic asymmetric route to novel chiral quaternary-carbon-containing cyclobutanone-fused 4-aminoquinoline derivatives in good to high yields and enantioselectivities is described. This process consists of a chiral phosphoric acid-catalyzed desymmetric carbonyl-amine condensation of prochiral cyclobutane-1,3-diones with 2-halogenated anilines and a Pd-catalyzed coupling reaction of ...

Mar 24th, 2023 - A series of new derivatives based on sulfamethoxazole were designed and synthesized in this study. The structures of the new compounds were confirmed based on a comprehensive characterization of spectral data by applied IR and 1H as well as 13C NMR spectroscopy. The prepared compounds were tested for their anticancer and antimicrobial properties. Hydrazone 16b demonstrated convincing anticancer...

Mar 24th, 2023 - Multiple sclerosis (MS) is an autoimmune neurodegenerative disease affecting numerous people worldwide. While the relapsing subtypes of MS are to some extent treatable, the disease remains incurable leading to progressive disability. Limited efficacy of current small molecule drugs necessitates development of efficient and safe MS medications. Accordingly, drug repurposing is an invaluable stra...

Mar 24th, 2023 - Efficient encapsulation and tumor targeting ability are the key issues for hydrophobic drugs delivery vectors in cancer therapy. In the current study, Rhodiola rosea polysaccharides (RHPs) serve as an immunoactive vector for drug delivery with tumor-associated macrophages (TAMs) modulating ability and typical structural characteristics. Firstly, Folic acid (FA) and stearic acid (SA) were chemic...

Mar 23rd, 2023 - Copper-catalyzed carboazidation of alkenes with trimethylsilyl azide and cyclic ethers has been achieved. The employment of naturally abundant copper catalysts allowed cyclic ethers to be used as alkylating reagents under oxidative conditions. The use of styrene derivatives and 1,1-diaryl alkenes afforded carboazidation products. In addition, application of five- and six-membered cyclic ethers ...

Mar 23rd, 2023 - Thiophene derivatives have been widely studied as promising options for the treatment of solid tumors. Previous studies have shown that thiophene derivatives have antileishmanial activity and cytotoxic activity against breast, colon, and ovarian cancer cells. In our study, we evaluated the anticancer activities of three aminothiophene derivatives: SB-44, SB-83, and SB-200, in prostate and cervi...