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About 353,883 results

CYP11A1‑derived vitamin D hydroxyderivatives as candidates for therapy of basal and squ...
https://doi.org/10.3892/ijo.2022.5386
International Journal of Oncology; Slominski AT, Brożyna AA et. al.

Jul 2nd, 2022 - Hydroxyderivatives of vitamin D3, including classical 1,25(OH)2D3 and novel CYP11A1‑derived hydroxyderivatives, exert their biological activity by acting as agonists on the vitamin D receptor (VDR) and inverse agonists on retinoid‑related orphan receptors (ROR)α and γ. The anticancer activities of CYP11A1‑derived hydroxyderivatives were tested using cell biology, tumor biology and molecular bio...

Early biochemical observations point to nutritional strategies to manage non-alcoholic ...
https://doi.org/10.1042/CS20220380
Clinical Science (London, England : 1979); Calder PC

Jul 2nd, 2022 - Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease globally. The first stage of NAFLD is steatosis, the accumulation of triacylglycerols within hepatocytes. Inflammation and oxidative stress both contribute to progression to more severe disease. In 2004 Clinical Science published two papers reporting on fatty acids and oxidative stress markers in the livers of patient...

New 2-alkylthio-1-benzylimidazole-5-carboxylic acid derivatives targeting gp41: design,...
https://doi.org/10.2174/1570162X20666220628154901
Current HIV Research; Mostashari-Rad T, Claes S et. al.

Jul 1st, 2022 - Background Although current available medications have increased the quality of life in HIV-infected patients, there are still some shortcomings in HIV treatment arising from viral resistance, drug side effects and high cost of medication. Therefore, there is an urgent need for some suitable HIV inhibitors with different mechanisms of action. Gp41, located on the HIV cell surface, plays an impo...

Association between mitochondrial DNA methylation and internal exposure to polycyclic a...
https://doi.org/10.1016/j.ecoenv.2022.113799
Ecotoxicology and Environmental Safety; Guo L, Liu Z et. al.

Jul 1st, 2022 - Polycyclic aromatic hydrocarbons (PAHs), nitrated-PAHs (NPAHs) and oxygenated-PAHs (OPAHs) are environmental pollutants with adverse effects on human health. The correlation between the concentrations of PAHs, NPAHs and OPAHs in human plasma and the methylation level of mitochondrial DNA (mtDNA) was investigated using data from 110 plasma samples collected in Tianjin, China. The median concentr...

Natural Products and their Derivatives as Immune Check Point Inhibitors: Targeting Cyto...
https://doi.org/10.1016/j.semcancer.2022.06.009
Seminars in Cancer Biology; Gupta M, Chandan K et. al.

Jul 1st, 2022 - Cancer immunotherapy is the new generation and widely accepted form of tumour treatment. It is, however, associated with exclusive challenges which include organ-specific inflammation, and single-target strategies. Therefore, approaches that can enhance the efficiency of existing immunotherapies and expand their indications are required for the further development of immunotherapy. Natural prod...

A MUC5B Gene Polymorphism, rs35705950-T Confers Protective Effects Against COVID-19 Hos...
https://doi.org/10.1164/rccm.202109-2166OC
American Journal of Respiratory and Critical Care Medicine; Verma A, Minnier J et. al.

Jul 1st, 2022 - A common MUC5B gene polymorphism, rs35705950-T, is associated with idiopathic pulmonary fibrosis (IPF), but its role in SARS-CoV-2 infection and disease severity is unclear. To assess whether rs35705950-T confers differential risk for clinical outcomes associated with COVID-19 infection among participants in the Million Veteran Program (MVP). The MUC5B rs35705950-T allele was directly genotyped...

Nanoengineered metal-organic framework architectures for adsorptive and photocatalytic ...
https://doi.org/10.1016/j.envpol.2022.119690
Environmental Pollution (Barking, Essex : 1987); Mumtaz N, Javaid A et. al.

Jul 1st, 2022 - Rapidly expanding water pollution has transformed into significant dangers around the world. In recent years, the pharmaceutical and agriculture field attained enormous progress to meet the necessities of health and life; however, discharge of trace amounts of pharmaceuticals and pesticides into water significantly have a negative influence on human health and the environment. Contamination wit...

Facile and general electrochemical deuteration of unactivated alkyl halides.
https://doi.org/10.1038/s41467-022-31435-9 10.1021/cr50004a004 10.1021/cr100436k 10.1021/acs.jmedchem.8b01808 10.1002/anie.202005765 10.1038/s41557-021-00846-4 10.1039/D2CC00344A 10.1021/jacs.1c12071 10.1021/acs.chemrev.1c00795 10.1149/1.2404353 10.1139/v74-060 10.1039/P29750000215 10.1021/jo00396a003 10.1039/C6OB00193A 10.1021/acs.joc.6b01609 10.1039/D1SC04259A 10.1021/jacs.8b07597 10.1038/s41467-017-02551-8 10.1039/C9QO00240E 10.1007/s11426-019-9672-8 10.1021/jacs.7b12105 10.1021/acs.orglett.0c00001 10.1021/acs.joc.9b02026 10.1038/s41467-021-23255-0 10.1021/cr0680843 10.1039/c3cs60464k 10.1021/acs.chemrev.7b00397 10.1021/acscatal.8b01682 10.1021/acs.accounts.9b00512 10.1021/acs.accounts.9b00511 10.1021/acs.accounts.9b00603 10.1039/D1CS00223F 10.1038/nature17431 10.1002/anie.201802748 10.1016/j.chempr.2017.10.001 10.1021/acs.orglett.7b03559 10.1038/s41586-019-1539-y 10.1126/science.abf2798 10.1038/s41929-020-00559-w 10.1016/j.scib.2021.07.011 10.1016/j.tet.2003.12.038 10.1016/j.electacta.2012.03.130 10.1021/jacs.0c08532 10.1126/science.abf2974 10.1016/j.tetlet.2013.04.127 10.1002/anie.201912753 10.1021/jacs.9b13117 10.1021/jacs.0c13093 10.1002/anie.201915418 10.1021/jacs.0c01475 10.1038/s41586-022-04540-4 10.1021/jacs.9b10678 10.1021/cs400587s 10.1021/jacs.1c03007 10.1002/anie.201900956 10.1021/jacs.9b01886 10.1021/jacs.1c03007 10.1002/anie.202016310 10.1016/S0022-0728(01)00397-7 10.1002/anie.202003218 10.1038/s41467-021-27437-8 10.1016/S0040-4039(01)01544-1 10.1002/anie.201004852 10.5796/electrochemistry.81.362 10.1002/anie.202009155 10.31635/ccschem.020.202000512 10.1038/s41929-020-00515-8 10.1021/jacs.1c06473
Nature Communications; Li P, Guo C et. al.

Jul 1st, 2022 - Herein, a facile and general electroreductive deuteration of unactivated alkyl halides (X = Cl, Br, I) or pseudo-halides (X = OMs) using D2O as the economical deuterium source was reported. In addition to primary and secondary alkyl halides, sterically hindered tertiary chlorides also work very well, affording the target deuterodehalogenated products with excellent efficiency and deuterium inco...

Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluatio...
https://doi.org/10.1002/ddr.21958
Drug Development Research; Keleş Atıcı R, Doğan ŞD et. al.

Jul 1st, 2022 - The recent emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) has complicated and significantly slowed efforts to eradicate and/or reduce the worldwide incidence of life-threatening acute and chronic cases of tuberculosis. To overcome this setback, researchers have increased the intensity of their work to identify new small-molecule compounds that are expected to remain eff...

Synthesis of Thiazole-2(3H)-ones via 3,3-Sigmatropic Rearrangement/5-exo-dig Cyclizatio...
https://doi.org/10.1021/acs.joc.2c00991
The Journal of Organic Chemistry; Behera BK, Shit S et. al.

Jul 1st, 2022 - An efficient methodology has been developed for the synthesis of both di- and trisubstituted thiazol-2(3H)-ones from N-propargylamines and silver(I) trifluoromethanethiolate (AgSCF3) in good yields. The reaction proceeds via [3,3]-sigmatropic rearrangement/5-exo-dig cyclization of N-propargylamines. The starting material can be easily prepared from the A3-coupling reaction of amines, aldehydes,...

Structure Revision of Trichomide D by Total Synthesis.
https://doi.org/10.1021/acs.jnatprod.2c00440
Journal of Natural Products; Yoshida M, Matsushita T et. al.

Jun 30th, 2022 - A structure revision of trichomide D has been achieved by its total synthesis. The sterically hindered peptide sequence was successfully prepared using not only a conventional amidation with EDCI but also coupling with an Fmoc-protected amino acid chloride derivative. The cyclization precursor was synthesized by coupling of a tetrapeptide with an acylproline derivative and subsequent removal of...

Risk of Hepatocellular Carcinoma With Tenofovir vs Entecavir Treatment for Chronic Hepa...
https://doi.org/10.1001/jamanetworkopen.2022.19407
JAMA Network Open; Tan DJH, Ng CH et. al.

Jun 30th, 2022 - Conventional meta-analyses with aggregated study-level data have yielded conflicting results for the comparative effectiveness of tenofovir disoproxil fumarate vs entecavir in reducing hepatocellular carcinoma (HCC) risk among patients with chronic hepatitis B virus. Within-study heterogeneity, between-study heterogeneity, and the inability of conventional meta-analyses to capture time-to-event...

Impact of different processing methods on the phenolics and neuroprotective activity of...
https://doi.org/10.1039/d2fo00645f
Food & Function; Ezzat MI, Issa MY et. al.

Jun 30th, 2022 - Age-related diseases, including dementia, are a major health concern affecting daily human life. Strawberry (Fragaria ananassa Duch.) is the most eaten fruit worldwide due to its exceptional aroma and flavor. However, it's rapid softening and decay limit its shelf-life. Freezing and boiling represent the well-known conservation methods to extend its shelf-life. Therefore, we aimed to discover t...

Development of a Translational Model to Assess the Impact of Opioid Overdose and Naloxo...
https://doi.org/10.1002/cpt.2696
Clinical Pharmacology and Therapeutics; Mann J, Samieegohar M et. al.

Jun 30th, 2022 - In response to a surge of deaths from synthetic opioid overdoses, there have been increased efforts to distribute naloxone products in community settings. Prior research has assessed the effectiveness of naloxone in the hospital setting; however, it is challenging to assess naloxone dosing regimens in the community/first-responder setting, including reversal of respiratory depression effects of...

Reconsidering the mechanisms of action of PARP inhibitors based on clinical outcomes.
https://doi.org/10.1111/cas.15477
Cancer Science; Onji H, Murai J

Jun 30th, 2022 - PARP inhibitors (PARPis) were initially developed as DNA repair inhibitors that inhibit the catalytic activity of PARP1 and PARP2 and are expected to induce synthetic lethality in BRCA- or homologous recombination (HR)-deficient tumors. However, the clinical indications for PARPis are not necessarily limited to BRCA mutations or HR deficiency; BRCA wild-type and HR-deficient cancers can also de...

Targeting gut microbial bile salt hydrolase (BSH) by diet supplements: new insights int...
https://doi.org/10.1039/d2fo01252a
Food & Function; Yang Y, Wu C

Jun 30th, 2022 - The gut microbiome is increasingly recognized as a vital organ that participates in nutrient acquisition, energy regulation and maintenance of human health. Targeted manipulation of the gut microbiota by dietary supplements has been validated as an effective approach to improve human health. Among various gut microbiome-host interactions, bile acids (BAs) are intensively metabolized by the gut ...

Archaeobotanical and chemical investigations on wine amphorae from San Felice Circeo (I...
https://doi.org/10.1371/journal.pone.0267129
PloS One; Chassouant L, Celant A et. al.

Jun 30th, 2022 - We hereby investigate the pitch used for coating three Roman amphorae from San Felice Circeo (Italy) through a multidisciplinary study. The identification of molecular biomarkers by gas chromatography-mass spectrometry is combined with archaeobotanical evidence of pollen and plant tissues of Vitis flowers. Diterpenic chemical markers together with Pinus pollen and wood revealed Pinaceae tar coa...

Isolation and characterization of auronlignan derivatives with hepatoprotective and hyp...
https://doi.org/10.1039/d2fo01079h
Food & Function; Ma Q, Guan Y et. al.

Jun 29th, 2022 - The fruit of Hippophae rhamnoides L. is not only used as delicious food with nutritional values, but also served as traditional Chinese medicine with multiple bioactivities. In order to find structurally interesting and bioactive isolates from the fruits of H. rhamnoides L., a bioassay-guided investigation was applied to seek the hepatoprotective and hypolipidemic ingredients in this study. As ...

Suncheonosides E-M and Benzothioate Derivatives from the Marine-Derived Streptomyces sp...
https://doi.org/10.1021/acs.jnatprod.2c00320
Journal of Natural Products; Jiang M, Zhang Y et. al.

Jun 29th, 2022 - Thirteen new compounds, including suncheonosides E-M (1-9), four benzothioate derivatives (10-13), and one known compound (14), were identified from the marine-derived Streptomyces sp. ZSN77. Suncheonosides E-M incorporate β-d-glucose, while the reported suncheonosides (A-D) incorporate only l-rhamnose. All of the structures were determined by extensive analysis of NMR spectroscopic and HRESIMS...

Novel transformation products from glucosinolate-derived thioglucose and isothiocyanate...
https://doi.org/10.1016/j.foodres.2022.111237
Food Research International (Ottawa, Ont.); Hoffmann H, Andernach L et. al.

Jun 29th, 2022 - Glucosinolates are plant secondary metabolites occurring in Brassicaceae plants. Upon tissue disruption, these compounds can be enzymatically hydrolyzed into isothiocyanates, which are very reactive and can react with nucleophiles during thermal processes such as boiling. Here, a novel type of glucosinolate degradation product was identified resulting from the reaction of thioglucose with the i...