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About 239,080 results

A rare case of coexistence of Wegener's granulomatosis and pulmonary tuberculosis with ...
https://doi.org/10.1186/s12879-021-06583-w 10.1177/0394632015617063 10.1080/08998280.2006.11928198 10.1002/art.1780390112 10.12688/f1000research.14626.1 10.1007/s00281-014-0436-6 10.2215/CJN.02500317 10.1155/2016/1075659 10.4046/trd.2014.77.4.161 10.1128/microbiolspec.TNMI7-0009-2016 10.1016/j.jaut.2014.01.028 10.1007/s10067-019-04693-0 10.1136/thx.41.10.737 10.1183/16000617.0077-2017 10.7326/0003-4819-123-12-199512150-00005 10.1038/modpathol.3880516 10.1007/s00296-012-2487-0 10.1093/rheumatology/keg066 10.1016/S0272-6386(88)80079-9 10.1046/j.1523-1755.1999.07005.x 10.1136/bcr-2017-221948 10.1016/j.kjms.2012.10.008 10.1590/S0004-282X2005000500025 10.5402/2011/608942 10.1136/ard.2008.099051 10.1136/practneurol-2019-002415 10.1159/000091188 10.1136/bjo.2007.114777 10.1159/000186268 10.1097/01.cpm.0000181642.91898.6e
BMC Infectious Diseases; Rostami Z, Cegolon L et. al.

Sep 16th, 2021 - Granulomatosis with polyangiitis (GPA), also known as Wegener's granulomatosis, is an idiopathic systemic disease typically affecting the lungs, although other organs may also be involved. A 28-year-old male was admitted to Baqiyatallah university hospital in Teheran (Iran) after a 3-week history of fever and productive cough. The patient gradually developed fatigue, arthralgia, hematuria, naus...

Oncogene-specific inhibition in the treatment of advanced pediatric thyroid cancer.
https://doi.org/10.1172/JCI152696
The Journal of Clinical Investigation; Franco AT, Ricarte-Filho JC et. al.

Sep 16th, 2021 - Papillary thyroid cancer (PTC) is the most common form of differentiated thyroid cancer in the pediatric population and represents the second most common malignancy in adolescent females. Historically, PTC has been classified on the basis of histology, however, accumulating data indicate that molecular subtyping based on somatic oncogenic alterations along with gene expression profiling can bet...

Exercise intervention decreases acute and late doxorubicin-induced cardiotoxicity.
https://doi.org/10.1002/cam4.4283
Cancer Medicine; Wang F, Chandra J et. al.

Sep 16th, 2021 - Doxorubicin (Dox) is one of the most effective chemotherapy agents used to treat adolescent and young adult sarcoma patients. Unfortunately, Dox causes cardiotoxicities that compromise long-term survival. We investigated whether exercise prevented cardiotoxicity and increased survival following myocardial infarction. Juvenile mice received Dox, Dox + exercise (Exer), Dox then exercise or were e...

Mediastinal lymph node dissection in older patients with non-small cell lung cancer.
https://doi.org/10.1007/s00595-021-02373-8 10.3322/caac.21262 10.1007/s11748-016-0695-3 10.1016/j.jtcvs.2010.11.008 10.1016/S1470-2045(06)70804-X 10.1200/JCO.2008.16.2727 10.1093/jjco/hyaa061 10.1097/JTO.0b013e3181ae285d 10.1510/icvts.2008.193383 10.1016/j.jss.2014.08.018 10.1093/ejcts/ezx415 10.1016/j.jtho.2016.06.028 10.1016/j.jtho.2015.09.009 10.1001/jama.1986.03370100110027 10.1038/sj.bjc.6602836 10.1093/icvts/ivv223 10.1097/01.sla.0000133083.54934.ae 10.1016/j.ejcts.2010.01.017 10.1097/ACO.0b013e32801158bb 10.1016/j.athoracsur.2012.03.057 10.1007/s00595-016-1380-y
Surgery Today; Maniwa T, Kimura T et. al.

Sep 16th, 2021 - We evaluated the impact of omitting mediastinal lymph node dissection (MLND) from the surgical treatment of non-small cell lung cancer (NSCLC) in older patients. We collected data retrospectively on 2475 patients who underwent pulmonary resection for NSCLC at our hospital between June, 2006 and December 2018. The subjects of this analysis were 209 patients aged ≥ 75 years who underwent lobectom...

Immunotherapy in Gastroesophageal Cancers: Current Evidence and Ongoing Trials.
https://doi.org/10.1007/s11864-021-00893-6 10.1158/1055-9965.EPI-15-0578 10.1200/JCO.2014.60.1799 10.1038/70932 10.1084/jem.192.7.1027 10.1146/annurev.immunol.23.021704.115611 10.1016/S1074-7613(00)80089-8 10.1038/nm730 10.1073/pnas.192461099 10.1084/jem.20082492 10.1038/nrc3239 10.1038/srep37933 10.2147/OTT.S138044 10.1371/journal.pone.0182692 10.1371/journal.pone.0131403 10.1097/MD.0000000000001911 10.2147/OTT.S118982 10.1016/S1470-2045(16)30406-5 10.1056/NEJMoa1910549 10.1016/j.annonc.2020.08.2299 10.2217/fon-2018-0581 10.1200/JCO.2019.37.4_suppl.5 10.1016/j.annonc.2020.08.2298 10.1001/jamaoncol.2020.3370 10.1016/j.annonc.2020.08.2296 10.1016/j.annonc.2020.08.2297 10.2217/fon-2018-0609 10.1200/JCO.2018.36.4_suppl.TPS192 10.1016/j.jtho.2018.08.568 10.1016/S0140-6736(09)61497-5 10.1200/JCO.2012.47.1102 10.1186/s40425-019-0508-1 10.1200/JCO.20.00892 10.1016/S0140-6736(18)31257-1 10.1200/JCO.2020.38.15_suppl.4503 10.1158/1078-0432.CCR-20-2980 10.1200/JCO.2019.37.4_suppl.2 10.1016/S1470-2045(19)30626-6 10.1016/S0140-6736(17)31827-5 10.1093/annonc/mdn169 10.1111/j.1365-2559.2008.03028.x 10.1093/annonc/mdi064 10.1200/JCO.2019.37.4_suppl.62 10.1200/JCO.2020.38.4_suppl.TPS463 10.1200/JCO.2021.39.3_suppl.218 10.1016/S1470-2045(20)30326-0 10.1038/nm.3850 10.18632/oncotarget.9076 10.1097/PAS.0000000000000698 10.1038/s41591-018-0101-z 10.1186/s40425-019-0514-3 10.1016/j.jcmgh.2017.02.003 10.3390/jcm9051427 10.1186/s12957-016-0969-3 10.1097/PAI.0000000000000264 10.1097/SLA.0000000000002803 10.1001/jamaoncol.2016.6762 10.1200/JCO.2019.37.15_suppl.4027 10.1200/JCO.2018.36.4_suppl.172 10.1200/JCO.2020.38.4_suppl.404 10.1093/annonc/mdy264 10.1001/jamaoncol.2018.0013 10.1001/jamaoncol.2018.5441
Current Treatment Options in Oncology; Huynh J, Patel K et. al.

Sep 16th, 2021 - Data supporting the use of immunotherapy in the treatment of gastroesophageal cancer continues to evolve. The promising results from adjuvant immunotherapy and trials combining immunotherapy plus chemotherapy in the 1L setting have led to broad US FDA approvals. Among the PD-L1 negative subgroups, the magnitude of benefit is diminished; effective therapy for this population remains an unmet nee...

Lower melanoma pulmonary metastatic burden in obese mice: role of FGF-21.
https://doi.org/10.1097/CMR.0000000000000781
Melanoma Research; Fonseca M, Soares R et. al.

Sep 16th, 2021 - Obesity is a risk factor for malignant melanoma. The lungs are main target organs for metastization and their immune response is a key modulator of this mechanism. The concept that the metastatic potential of some types of cancer is reduced or inhibited by obesity, known as the obesity paradox, drives major concerns on the prognosis of metastasized patients. The aim of this study was to investi...

High-grade endometrial carcinoma limited to the endometrium or a polyp: is adjuvant tre...
https://doi.org/10.1136/ijgc-2021-002771
International Journal of Gynecological Cancer : Official ... Dallaire Nantel L, Renaud MC et. al.

Sep 15th, 2021 - High-grade endometrial carcinoma limited to the endometrium or a polyp is a rare clinical entity. Currently there is no consensus on standard treatment. Thus, the goal of this study was to evaluate the clinical outcomes of patients with type II endometrial carcinoma without myometrial infiltration or limited to a polyp. We retrospectively identified type II endometrial carcinoma (FIGO endometri...

Blood cysts of the cardiac valves in adults: Review and analysis of published cases.
https://doi.org/10.1111/jocs.15992
Journal of Cardiac Surgery; Bortolotti U, Vendramin I et. al.

Sep 15th, 2021 - Blood cysts of cardiac valves are generally seen in newborns and infants and very rarely in adults. Although in most cases they are incidental findings they may be associated to severe cardiac or systemic complications. This study analyzes incidence, presentation, and treatment of valvular blood cysts in adults. A review of the pertinent literature through a search mainly on PubMed and Medline ...

The RNA binding protein HuR is a gatekeeper of liver homeostasis.
https://doi.org/10.1002/hep.32153
Hepatology (Baltimore, Md.); Subramanian P, Gargani S et. al.

Sep 15th, 2021 - Non-alcoholic fatty liver disease (NAFLD) is initiated by steatosis and can progress via fibrosis and cirrhosis to hepatocellular carcinoma (HCC). The RNA binding protein HuR controls RNAs at the posttranscriptional level; hepatocyte HuR has been implicated in the regulation of diet-induced hepatic steatosis. The present study aimed to understand the role of hepatocyte-HuR in NAFLD development ...

Childhood head trauma and the risk of childhood brain tumours: a case-control study in ...
https://doi.org/10.1002/ijc.33805
International Journal of Cancer; Cheng S, McLaughlin JR et. al.

Sep 15th, 2021 - Head trauma in early childhood has been hypothesized as a potential risk factor for childhood brain tumours (CBTs). However, head trauma has not been extensively studied in the context of CBTs and existing studies have yielded conflicting results. A population- and hospital-based case-control study of children 0-15 years with newly diagnosed CBTs from 1997-2003 recruited across Ontario through ...

Potential role of functional imaging in predicting outcome for patients treated with ca...
https://doi.org/10.1259/bjr.20210524
The British Journal of Radiology; Riva G, Imparato S et. al.

Sep 15th, 2021 - Carbon ion radiation therapy (CIRT) is an emerging radiation technique with advantageous physical and radiobiologic properties compared to conventional radiotherapy (RT) providing better response in case of radioresistant and hypoxic tumors. Our aim is to critically review if functional imaging techniques could play a role in predicting outcome of CIRT-treated tumors, as already proven for conv...

Clinical outcomes in patients with metastatic renal cell carcinoma and brain metastasis...
https://doi.org/10.1136/jitc-2021-003281
Journal for Immunotherapy of Cancer; Brown LC, Desai K et. al.

Sep 15th, 2021 - The combination of ipilimumab plus nivolumab (I+N) has greatly improved outcomes in patients with intermediate or poor-risk untreated metastatic renal cell carcinoma (mRCC). However, little is known about the outcomes of patients with brain metastasis (BrM) treated with I+N. A search was performed to retrospectively identify all patients with mRCC treated with I+N in the Duke Cancer Institute a...

Late relapsing germ cell tumors with elevated tumor markers.
https://doi.org/10.1007/s00345-021-03833-z 10.1200/JCO.2006.08.1836 10.1097/00000478-200002000-00012 10.1007/s00345-004-0397-9 10.1200/JCO.1995.13.5.1170 10.1200/JCO.1997.15.2.594 10.1016/j.urolonc.2010.04.007 10.1038/sj.bjc.6603014 10.1200/JCO.2007.15.7453 10.1002/1097-0142(19800715)46:2<380::AID-CNCR2820460228>3.0.CO;2-U 10.1101/gad.10.13.1670 10.1097/PAS.0000000000000322 10.1111/his.13102 10.1002/cncr.29996
World Journal of Urology; Che Y, Lusch A et. al.

Sep 15th, 2021 - Late relapsing germ cell tumors (LR-GCT) are considered a rare distinct biologic entity as their clinical presentation and response to treatment is different to early recurrences. While serum tumor markers (AFP and ß-HCG) play an important role at the time of first diagnosis to correctly classify prognosis and treatment of germ cell tumors, they may not have the same significance in a late rela...

Efficacy and safety of cap-assisted endoscopic mucosal resection for treatment of nonli...
https://doi.org/10.1055/a-1559-2391
Endoscopy Van der Voort VRH, Moons LMG et. al.

Sep 15th, 2021 - BACKGROUND : Suboptimal lifting increases complexity of endoscopic mucosal resection (EMR) for benign colorectal polyps. Cap-assisted EMR (EMR-C) may allow fibrotic polyp tissue to be captured in the snare. This study evaluated the efficacy and safety of EMR-C for benign nonlifting colorectal polyps. METHODS : This was a multicenter study, which prospectively registered all EMR-C procedures (20...

Altered cardiac structure and function is related to seizure frequency in a rat model o...
https://doi.org/10.1016/j.nbd.2021.105505
Neurobiology of Disease; Powell KL, Liu Z et. al.

Sep 15th, 2021 - This study aimed to prospectively examine cardiac structure and function in the kainic acid-induced post-status epilepticus (post-KA SE) model of chronic acquired temporal lobe epilepsy (TLE), specifically to examine for changes between the pre-epileptic, early epileptogenesis and the chronic epilepsy stages. We also aimed to examine whether any changes related to the seizure frequency in indiv...

Adenomyosis: an update regarding its diagnosis and clinical features.
https://doi.org/10.1016/j.jogoh.2021.102228
Journal of Gynecology Obstetrics and Human Reproduction; Bourdon M, Santulli P et. al.

Sep 15th, 2021 - Adenomyosis is a common gynecologic disease characterized by invasion of endometrial glands and stroma within the myometrium. Clinically, it can result in abnormal uterine bleeding, pelvic pain, and infertility. Adenomyosis has historically been diagnosed by histology of hysterectomy specimens. As a result of the development of imaging techniques, the diagnosis is nowadays possible by means of ...

Local ablative treatment with surgery and/or radiotherapy in single-site and oligometas...
https://doi.org/10.1016/j.ejca.2021.08.019
European Journal of Cancer (Oxford, England : 1990); Pouyiourou M, Wohlfromm T et. al.

Sep 15th, 2021 - Single-site carcinoma of unknown primary (CUP) is recognised as a distinct favourable subtype in the European Society of Medical Oncology (ESMO) classification. There is broad consensus that these patients are candidates for local ablative treatment strategies with surgery and/or radiotherapy, but data on their outcomes are scarce. In this study, we have addressed the prospects of cure and prog...

Prevalence of Regional Lymph Node Metastasis of Mucosal Gastric Signet Ring Cell Carcin...
https://doi.org/10.1159/000518898
Digestive Surgery; Jeong SH, Kim JW et. al.

Sep 15th, 2021 - Patients with very early-stage gastric signet ring cell carcinoma (SRC) are eligible for minimally invasive treatment, like endoscopic submucosal dissection. However, population-based data on regional lymph node metastasis (LNM) and distant metastasis of gastric SRC are lacking. This study aimed to identify the prevalence of LNM and distant metastasis in mucosal cancer (T1a) of gastric SRC. The...

Anaplastic Sarcoma of the Kidney With Heterologous Ganglioneuroblastic Differentiation:...
https://doi.org/10.1177/10935266211043861
Pediatric and Developmental Pathology : the Official Jour... Kroll-Wheeler L, Heider A

Sep 14th, 2021 - Anaplastic sarcoma of the kidney (ASK) is a rare renal tumor for which less than thirty cases have been described in the literature to date. Diagnosis of ASK is primarily based on histology, which features solid spindle cell neoplastic islands arranged in a fascicular pattern, prominent anaplastic nuclear morphology, brisk mitoses, and multiple multiloculated cysts lined by hobnail epithelium r...

Prognostic and predictive value of mismatch repair deficiency in gastric and gastroesop...
https://doi.org/10.1002/jso.26669
Journal of Surgical Oncology; Li Z, Wang Y et. al.

Sep 14th, 2021 - Evidence is inconclusive regarding the prognostic significance of deficient DNA mismatch repair (dMMR) in gastric and gastroesophageal junction (GEJ) adenocarcinoma patients receiving chemotherapy. We aim to explore such associations with a large cohort. We retrospectively identified a consecutive cohort of patients who had histology proven gastric or GEJ adenocarcinoma and received neoadjuvant...