×
About 251,658 results

Novel endoscopic ultrasonography classification for assured vertical resection margin (...
https://doi.org/10.1111/jgh.16008
Journal of Gastroenterology and Hepatology; Kamigaichi Y, Oka S et. al.

Oct 2nd, 2022 - The risk of local recurrence might be low in pT1 colorectal carcinoma with a tumor vertical margin (VM) ≥500 μm. We investigated the relationship between endoscopic ultrasonography (EUS) findings and VM in cases with colorectal endoscopic submucosal dissection (ESD) categorized as Type 2B according to the Japan NBI Expert Team (JNET) classification. We analyzed 179 JNET Type 2B colorectal tumor...

Body mass index and additional risk factors for cancer in adults with cystic fibrosis.
https://doi.org/10.1007/s10552-022-01635-1
Cancer Causes & Control : CCC; Knotts RM, Jin Z et. al.

Oct 1st, 2022 - Adults with cystic fibrosis (CF) have an increased risk of a variety of cancers, notably gastrointestinal cancers. In CF higher body mass index (BMI) is associated with improved long-term outcomes, yet in the general population high BMI is associated with increased cancer risk. We aimed to delineate associations between BMI and other factors with cancer risk in adults with CF. This was a retros...

Epidemiology of overall and early-onset serrated polyps versus conventional adenomas in...
https://doi.org/10.1002/ijc.34306
International Journal of Cancer; Vithayathil M, Smith S et. al.

Oct 1st, 2022 - Serrated polyps (SPs) are precursors to one-third of colorectal cancers (CRCs), with histological subtypes: hyperplastic polyps (HPs), sessile serrated lesions (SSLs), and traditional serrated adenomas (TSAs). The incidence of early-onset CRC before the age of 50 is increasing, with limited understanding of SPs in younger cohorts. Using a large colonoscopy-based cohort, we characterized epidemi...

Benign descriptors and ADNEX in two-step strategy to estimate risk of malignancy in ova...
https://doi.org/10.1002/uog.26080
Ultrasound in Obstetrics & Gynecology : the Official Jour... Landolfo C, Bourne T et. al.

Oct 1st, 2022 - Previous work suggested that the ultrasound-based benign Simple Descriptors can reliably exclude malignancy in a large proportion of women presenting with an adnexal mass. We aim to validate a modified version of the Benign Simple Descriptors (BD), and we introduce a two-step strategy to estimate the risk of malignancy: if the BDs do not apply, the ADNEX model is used to estimate the risk of ma...

Intraoperative frozen section analysis of margin status as a quality indicator in gastr...
https://doi.org/10.1002/jso.27107
Journal of Surgical Oncology; Watanabe A, Adamson H et. al.

Oct 1st, 2022 - Positive pathologic margins following gastric cancer (GC) resection carries a poor prognosis. We evaluated intraoperative frozen section (IFS) analysis of resection margins (RMs) as a quality indicator in GC surgery. Patients referred to a provincial cancer agency with surgically resected non-metastatic GC between 2004 and 2012 were included. Associations between IFS analysis, other baseline ch...

Does the character of the hospital of primary management influence outcomes in patients...
https://doi.org/10.1080/01443615.2022.2126753
Journal of Obstetrics and Gynaecology : the Journal of Th... McGowan M, Addley S et. al.

Oct 1st, 2022 - A retrospective study from 2015 to 2020 comparing overall survival (OS) outcomes of a cancer unit and centre for presumed early stage endometrial cancers is presented. Cancer centres manage these presumed early endometrial cancer (EC) in situations of complex co-morbidities, surgical challenges as well as their own local unit patients. Our analysis compares 138 patients at KMH (unit) and 282 pa...

Clinicopathologic and molecular spectrum of testicular sex cord-stromal tumors not amen...
https://doi.org/10.1038/s41379-022-01155-y
Modern Pathology : an Official Journal of the United Stat... Siegmund SE, Sholl LM et. al.

Oct 1st, 2022 - A subset of testicular sex cord-stromal tumors (SCST), which includes neoplasms with mixed histology, cannot be classified into a specific histologic subtype. This study evaluated the clinicopathologic, immunophenotypic and molecular features of 26 SCST not amenable to specific classification by expert uropathologists. Median age at diagnosis was 43 years and median tumor size was 2.4 cm. Follo...

Bone Metabolism in Charcot.
https://doi.org/10.1016/j.cpm.2022.05.002
Clinics in Podiatric Medicine and Surgery; Grant-McDonald L, Grant W

Oct 1st, 2022 - Bone metabolism in the healthy, young adult is identified as a relatively stable process. Normal bone turnover is a dynamic state, which is conferred through intracellular signaling and complex cellular pathways. It has been well described in the literature that Charcot neuro-osteoarthropathy is a disease state, which is marked by intense bone turnover leading to structural collapse and dissolu...

Bone characteristics in condylar hyperplasia of the temporomandibular joint: a microcom...
https://doi.org/10.1016/j.ijom.2022.09.030
International Journal of Oral and Maxillofacial Surgery; Kün-Darbois JD, Bertin H et. al.

Oct 1st, 2022 - Unilateral condylar hyperplasia (UCH) of the temporomandibular joint is a progressive deformation of the mandibular condyle of unknown origin. UCH is characterized by excessive growth of the condylar head and neck, leading to an increase in size and volume. The aim of this study was to investigate the characteristics of the bone in patients with UCH using microcomputed tomography (micro-CT), hi...

Ramucirumab plus atezolizumab in patients with stage IV non-small cell lung cancer prev...
https://doi.org/10.1016/j.lungcan.2022.09.011
Lung Cancer (Amsterdam, Netherlands); Herzog BH, Waqar SN et. al.

Oct 1st, 2022 - The treatment options for patients with stage IV non-small cell lung cancer (NSCLC) who develop tumor progression after platinum-based chemotherapy and immune checkpoint inhibitors (ICIs) are limited. The combination of ICI with inhibitors of vascular endothelial growth receptor (VEGFR) signaling has shown promising results in previously untreated patients. In this single institution phase II s...

Duodenal diverticulum metastasis from pulmonary squamous cell carcinoma diagnosed by EU...
https://doi.org/10.1007/s12328-022-01693-7
Clinical Journal of Gastroenterology; Sunaga K, Yoshioka T et. al.

Sep 30th, 2022 - A 76-year-old male with pulmonary squamous cell carcinoma achieved complete response by chemoradiotherapy and subsequent systemic chemotherapy. During follow-up, fluorodeoxyglucose positron emission tomography/computed tomography showed strong fluorodeoxyglucose accumulation near the duodenal papilla. Elevated lesions were observed in the duodenal diverticulum upon lateral-viewing endoscopy, an...

Malignant struma ovarii with thyroid-type papillary and poorly differentiated carcinoma...
https://doi.org/10.1186/s13256-022-03590-6
Journal of Medical Case Reports; Terayama N, Fujiwara S et. al.

Sep 30th, 2022 - Malignant struma ovarii is a very rare type of gynecologic cancer. Although its most common histological subtype is a pure type of papillary thyroid carcinoma containing two components, papillary carcinoma and poorly differentiated carcinoma, malignant struma ovarii is still extremely rare. As a result, the optimal treatment for this type of tumor remains uncertain due to its rarity. A 62-year-...

Aortic Cellular Diversity and Quantitative Genome-Wide Association Study Trait Prioriti...
https://doi.org/10.1161/ATVBAHA.122.317953
Arteriosclerosis, Thrombosis, and Vascular Biology; Chou EL, Chaffin M et. al.

Sep 30th, 2022 - Mural cells in ascending aortic aneurysms undergo phenotypic changes that promote extracellular matrix destruction and structural weakening. To explore this biology, we analyzed the transcriptional features of thoracic aortic tissue. Single-nuclear RNA sequencing was performed on 13 samples from human donors, 6 with thoracic aortic aneurysm, and 7 without aneurysm. Individual transcriptomes wer...

RANKL inhibition for giant cell lesions of the jaw: A retrospective cohort analysis.
https://doi.org/10.1016/j.ejca.2022.08.011
European Journal of Cancer (Oxford, England : 1990); Schreuder WH, Lipplaa A et. al.

Sep 30th, 2022 - In all giant-cell-rich lesions (GCRL) occurring in bone, a common underlying excessive RANKL expression is held responsible for the osteolytic activity. Apart from giant cell tumour of bone (GCTB), systematic outcome analysis of RANKL inhibition in other GCRL is unavailable. The aim of this study is to assess the efficacy and safety of a 1-year denosumab protocol in giant cell lesions of the ja...

Endometrial carcinoma with diffuse melanocytic differentiation: Clinicopathological and...
https://doi.org/10.1016/j.prp.2022.154122
Pathology, Research and Practice; Arciuolo D, Travaglino A et. al.

Sep 30th, 2022 - Herein, we present a clinicopathological and molecular analysis of a case of endometrial carcinoma with diffuse melanocytic differentiation with literature review. A 72-year-old woman underwent hysterectomy due to a 14 cm endometrial mass. On histology, the tumor showed a serous carcinoma component and a solid component with giant eosinophilic and dyshesive multinucleated cells. Differential di...

Acute Myocarditis Associated With Desmosomal Gene Variants.
https://doi.org/10.1016/j.jchf.2022.06.013
JACC. Heart Failure; Ammirati E, Raimondi F et. al.

Sep 30th, 2022 - The risk of adverse cardiovascular events in patients with acute myocarditis (AM) and desmosomal gene variants (DGV) remains unknown. The purpose of this study was to ascertain the risk of death, ventricular arrhythmias, recurrent myocarditis, and heart failure (main endpoint) in patients with AM and pathogenic or likely pathogenetic DGV. In a retrospective international study from 23 hospitals...

Plaque histology and myocardial disease in sudden coronary death: the Fingesture study.
https://doi.org/10.1093/eurheartj/ehac533
European Heart Journal; Holmström L, Juntunen S et. al.

Sep 30th, 2022 - At least 50% of deaths due to coronary artery disease (CAD) are sudden cardiac deaths (SCDs), but the role of acute plaque complications on the incidence of sudden death in CAD is somewhat unclear. The present study aimed to investigate plaque histology and concomitant myocardial disease in sudden coronary death. The study population is derived from the Fingesture study, which has collected dat...

Polystyrene nanoparticles enhance the adverse effects of di-(2-ethylhexyl) phthalate on...
https://doi.org/10.1016/j.ecoenv.2022.114104
Ecotoxicology and Environmental Safety; Li D, Sun W et. al.

Sep 30th, 2022 - Coexposure of nanoplastics (NPs) with other pollutants adsorbed from the surroundings has received extensive attention. Currently, the combined effects of NPs and plasticizers remain unclear. Di-(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer that has raised much concern owing to its ubiquitous pollution and endocrine-disrupting potential. This study aimed to investigate the toxi...

Patterns of recurrences in sinonasal cancers undergoing an endoscopic surgery-based tre...
https://doi.org/10.1016/j.oraloncology.2022.106123
Oral Oncology; Arosio AD, Bernasconi DP et. al.

Sep 30th, 2022 - The improvements in survival with expansion of the survivors' population, along with evolution of endoscopically-based treatment modalities, have contributed to emphasize the clinical relevance of recurrences in sinonasal cancers. However, at present, literature is scant regarding the pattern of recurrences and the therapeutic strategies available to manage long survivors who experienced single...

The effect of chemotherapy on survival in oldest old patients with nonmetastatic triple...
https://doi.org/10.1111/jcpt.13776
Journal of Clinical Pharmacy and Therapeutics; Wu B, Sun C et. al.

Sep 30th, 2022 - Chemotherapy is the primary pharmacotherapy of triple-negative breast cancer (TNBC). But the benefit of adjuvant chemotherapy in the oldest old TNBC patients remains controversial. Hence, we designed this population based observational study in order to assess the survival benefit of adjuvant chemotherapy in oldest old TNBC patients with early-stage disease. TNBC patients aged 80 years and olde...