×
About 248,508 results

Hepatic ultrastructural features distinguish pediatric Wilson disease from NAFLD and au...
https://doi.org/10.1111/liv.15319
Liver International : Official Journal of the Internation... Alqahtani SA, Chami R et. al.

May 24th, 2022 - Wilson disease (WD) has diverse presentations that frequently mimic other liver diseases. Distinguishing WD from non-alcoholic fatty liver disease (NAFLD) and autoimmune hepatitis (AIH), can be difficult and has critical implications for medical management. This study aimed to examine the utility of histological features of WD in children compared to those with NAFLD and AIH. A review of liver ...

Supramolecular Hydrogel Based Post-Surgical Implant System for Hydrophobic Drug Deliver...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122075
International Journal of Nanomedicine; Wanjale MV, Sunil Jaikumar V et. al.

May 24th, 2022 - The brain, protected by the cranium externally and the blood-brain barrier (BBB) internally, poses challenges in chemotherapy of aggressive brain tumors. Maximal tumor resection followed by radiation and chemotherapy is the standard treatment protocol; however, a substantial number of patients suffer from recurrence. Systemic circulation of drugs causes myelodysplasia and other side effects. To...

Retinal Pathophysiological Evaluation in a Rat Model.
https://doi.org/10.3791/63111
Journal of Visualized Experiments : JoVE; Malani M, Nirmal J

May 24th, 2022 - A posterior segment eye disease like diabetic retinopathy alters the physiology of the retina. Diabetic retinopathy is characterized by a retinal detachment, breakdown of the blood-retinal barrier (BRB), and retinal angiogenesis. An in vivo rat model is a valuable experimental tool to examine the changes in the structure and function of the retina. We propose three different experimental techni...

Feasibility, efficacy, and cautionary note of endoscopic resection for gastric tube can...
https://doi.org/10.1007/s00464-022-09240-8 10.1002/bjs.1800790319 10.1055/s-2007-1005628 10.1007/s00464-003-8820-7 10.1200/JCO.2003.12.095 10.1016/S0140-6736(02)08651-8 10.1200/JCO.2009.22.2083 10.1245/s10434-011-2049-9 10.1016/S1072-7515(02)01135-3 10.1007/s10120-006-0408-1 10.1200/JCO.2005.19.935 10.1055/s-2001-16224 10.1136/gut.48.2.225 10.1007/s00535-006-1954-3 10.1007/s10120-006-0389-0 10.1016/j.gie.2013.07.059 10.1007/s00464-009-0766-y 10.1111/j.1443-1661.2009.00912.x 10.1055/s-0031-1291712 10.1055/s-0029-1215024 10.1093/jjco/hyf083 10.1016/j.athoracsur.2003.09.071 10.3748/wjg.v21.i3.919 10.1007/s10388-018-00653-w 10.3748/wjg.v27.i11.1043 10.1007/s10120-011-0042-4 10.1038/bmt.2012.244 10.1007/BF02913915 10.1245/s10434-008-9871-8 10.1007/PL00011720 10.1002/bjs.7033 10.1136/gut.2008.165381 10.1111/j.1443-1661.2005.00459.x 10.1186/s12957-015-0705-4 10.1046/j.1365-2168.2001.01696.x 10.1046/j.1442-2050.2000.00116.x 10.1200/JCO.2003.12.074 10.1016/S0003-4975(03)00957-3 10.1007/s00268-004-7525-y 10.1007/s10120-006-0372-9 10.1007/s10388-018-0641-9
Surgical Endoscopy; Inokuchi Y, Watanabe M et. al.

May 24th, 2022 - Gastric tube cancer (GTC), whose usual histology is adenocarcinoma, occurs frequently as a result of improved survival after esophagectomy. Whether endoscopic resection (ER) for GTC is safe and suitable and guidelines for treatment and follow-up remains unclear. Patients with GTC who underwent ER at Kanagawa Cancer Center Hospital between 1997 and 2020 were studied retrospectively to evaluate c...

Stereotactic Magnetic Resonance Guided Adaptive Radiation Therapy (SMART) for Abdominop...
https://doi.org/10.1016/j.ijrobp.2022.05.016
International Journal of Radiation Oncology, Biology, Phy... Yang DD, Brennan VS et. al.

May 23rd, 2022 - Stereotactic body radiation therapy can be an effective treatment for oligometastases. However, safe delivery of ablative radiation is frequently limited by the proximity of mobile organs sensitive to high radiation doses. The goal of this study is to determine the feasibility, safety, and disease control outcomes of stereotactic magnetic resonance guided adaptive radiation therapy (SMART) in p...

Stereotactic body radiotherapy for spinal metastases: a review.
https://doi.org/10.1007/s12032-021-01613-8 10.1001/jamaoncol.2019.5351
Medical Oncology (Northwood, London, England); Guo L, Ke L et. al.

May 23rd, 2022 - To evaluate the efficacy and safety of stereotactic body radiotherapy (SBRT) in treating spinal metastases. Two reviewers performed independent literature searches of the PubMed database, searching literatures of the efficacy and safety of SBRT in metastatic spinal diseases. A total of 67 studies were included in the review. Regarding SBRT for de novo spinal metastases, the 1- and 2-year local ...

Histology-tailored multidisciplinary management of primary retroperitoneal sarcomas.
https://doi.org/10.1016/j.ejso.2022.05.010
European Journal of Surgical Oncology : the Journal of Th... Bonvalot S, Roland C et. al.

May 23rd, 2022 - Until recently, the recommendation for primary retroperitoneal sarcomas (RPS) was to perform a complete en-bloc gross excision, (neo) adjuvant treatments being options which were not validated by randomized studies, with a large discrepancy of use between centers. The heterogeneity of RPS, with their different biological behaviour, renders a homogenous therapeutic and surgical approach probably...

Anti-HBc levels are associated with liver inflammation and response to peginterferon in...
https://doi.org/10.1093/infdis/jiac210
The Journal of Infectious Diseases; Brakenhoff SM, de Knegt RJ et. al.

May 23rd, 2022 - Emerging evidence suggests a pivotal role for B-cell responses in the natural history of chronic hepatitis B (CHB). Serum levels of antibodies to HBcAg (anti-HBc) vary across infection stages, but their role in predicting response to antiviral therapy is uncertain. Anti-HBc levels were assessed before peginterferon (PEG-IFN) therapy in CHB patients who either initiated de novo PEG-IFN (n = 299;...

Utilization of pre-procurement biopsy in donation-after-circulatory death (DCD) liver t...
https://doi.org/10.1002/lt.26510
Liver Transplantation : Official Publication of the Ameri... Bolognese AC, Foley DP et. al.

May 22nd, 2022 - We perform routine pre-procurement image-guided percutaneous liver biopsies on potential DCD liver donors. The purpose of this study was to examine the impact of pre-procurement liver biopsy on utilization of livers from DCD donors. We retrospectively reviewed demographics, liver histology, and disposition of DCD liver donors within a single organ procurement organization (OPO) who underwent pr...

The 2015 American Thyroid Association guidelines and trends in hemithyroidectomy utiliz...
https://doi.org/10.1002/hed.27098
Head & Neck; Stein E, Raval MV et. al.

May 22nd, 2022 - In 2015, the American Thyroid Association (ATA) released its inaugural recommendations for the management of thyroid cancer in children. We aim to evaluate whether there has been a change in hemithyroidectomy utilization for pediatric differentiated thyroid cancer, and the association between those changes and the release of the ATA guidelines. The National Cancer Database was queried and ident...

High-temperature stress will put the thermo-sensitive teleost yellow catfish (Tachysuru...
https://doi.org/10.1016/j.ecoenv.2022.113638
Ecotoxicology and Environmental Safety; Yu Y, Chen M et. al.

May 22nd, 2022 - Recently, concerns for species that sex differentiation is influenced by temperature in the context of global warming have increased because disrupted operational sex ratios could threaten population maintenance. In contrast, little attention has been given to the reproductive ability of populations that experienced elevated temperatures. In this study, we demonstrated that high temperature (HT...

Long-range functional connections mirror and link microarchitectural and cognitive hier...
https://doi.org/10.1093/cercor/bhac172
Cerebral Cortex (New York, N.Y. : 1991); Wang Y, Royer J et. al.

May 22nd, 2022 - Higher-order cognition is hypothesized to be implemented via distributed cortical networks that are linked via long-range connections. However, it is unknown how computational advantages of long-range connections reflect cortical microstructure and microcircuitry. We investigated this question by (i) profiling long-range cortical connectivity using resting-state functional magnetic resonance im...

Surgical anatomy of the vaginal introitus.
https://doi.org/10.1002/nau.24961
Neurourology and Urodynamics; Haylen BT, Vu D et. al.

May 21st, 2022 - The vaginal introitus is the entrance to the vagina, encompassing the anterior and posterior vestibules and the perineum. The surgical anatomy of the vaginal introitus, the lowest level of the vagina, has not been subject to a recent comprehensive examination and description. Vaginal introital surgery (perineorrhaphy) should be a key part of surgery for a majority of pelvic organ prolapse. Cada...

Birth asphyxia is under-rated as a cause of preterm neonatal mortality in low- and midd...
https://doi.org/10.1111/1471-0528.17220
BJOG : an International Journal of Obstetrics and Gynaeco... Goldenberg RL, Dhaded S et. al.

May 21st, 2022 - Among preterm neonatal deaths, to assess respiratory distress syndrome (RDS) compared to birth asphyxia as the cause of death assigned by the neonatal intensive care unit (NICU) physician at the time of death to the cause of death assigned by a panel with complete obstetric history, placental evaluation, tissue histology and microbiology. Prospective, observational study SETTINGS: Study NICUs i...

Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver...
https://doi.org/10.1016/j.jep.2022.115394
Journal of Ethnopharmacology; Li H, Gao YH et. al.

May 21st, 2022 - Panax ginseng C. A. Meyer (ginseng) is a widely used traditional Chinese medicine that has played a beneficial role in the treatment of various diseases, including liver diseases. Ginsenoside Rg1 is a saponin isolated and purified from ginseng that exerts protective effects on the liver in some liver injury models. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitous dioxin found mostly i...

Induced antibodies directed to the angiotensin receptor type 1 provoke skin and lung in...
https://doi.org/10.1136/annrheumdis-2021-222088
Annals of the Rheumatic Diseases; Yue X, Yin J et. al.

May 21st, 2022 - To determine contributions and functions of autoantibodies (Abs) directed to the angiotensin receptor type 1 (AT1R), which are suggested to be involved in the pathogenesis of AT1R Abs-related diseases such as systemic sclerosis (SSc). C57BL/6J mice were immunised with membrane-embedded human AT1R or empty membrane as control. Mice deficient for CD4+ or CD8+ T cells and B cells were immunised wi...

Outcome of breast cancer patients treated with chemotherapy during pregnancy compared w...
https://doi.org/10.1016/j.ejca.2022.04.014
European Journal of Cancer (Oxford, England : 1990); Amant F, Nekljudova V et. al.

May 21st, 2022 - A diagnosis of breast cancer during pregnancy (PrBC) does not impact prognosis if standard treatment is offered. However, caution is warranted as gestational changes in pharmacokinetics may lead to reduced chemotherapy concentration. Survival of PrBC patients treated with chemotherapy during pregnancy was compared to non-pregnant breast cancer patients treated with chemotherapy, diagnosed after...

Percutaneous Radiofrequency Ablation to Occlude the Thoracic Duct: Preclinical Studies ...
https://doi.org/10.1016/j.jvir.2022.05.007
Journal of Vascular and Interventional Radiology : JVIR; McGregor H, Weise L et. al.

May 21st, 2022 - To investigate the feasibility of percutaneous radiofrequency ablation (RFA) to occlude the thoracic duct (TD) in a swine model with imaging and histologic correlation. Six swine underwent TD RFA. Two terminal (4 hours; 1 open, 1 percutaneous) and four survival (30 days; all percutaneous) studies were performed. Two 20-gauge needles were placed adjacent to the TD under direct visualization afte...

Factors influencing outcomes of older children with medulloblastoma over 15 years in Pe...
https://doi.org/10.1002/pbc.29770
Pediatric Blood & Cancer; Diaz-Coronado RY, Reinecke JB et. al.

May 21st, 2022 - Medulloblastoma is the most common malignant brain tumor in children. While survival has improved in high-income countries (HIC), the outcomes for patients in low-to-middle-income countries (LMIC) are unclear. Therefore, we sought to determine the survival of children with medulloblastoma at the Instituto Nacional de Enfermedades Neoplasicas (INEN) between 1997 and 2013 in Peru. Between 1997 an...

Focal segmental glomerulosclerosis: Risk for recurrence and interventions to optimize o...
https://doi.org/10.1111/petr.14307
Pediatric Transplantation; Harshman LA, Bartosh S et. al.

May 20th, 2022 - FSGS is a common indication for kidney transplant with a high-risk of posttransplant recurrence. In this review, we summarize current knowledge about FSGS recurrence after kidney transplantation, including epidemiology, pretransplant planning, posttransplant management, and investigational treatments. FSGS recurs in 14%-60% of first transplants, likely associated with a circulating permeability...