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About 198,544 results

A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing d...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104022
The Lancet. Neurology; Sabater L, Gaig C et. al.

Apr 7th, 2014 - Autoimmunity might be associated with or implicated in sleep and neurodegenerative disorders. We aimed to describe the features of a novel neurological syndrome associated with prominent sleep dysfunction and antibodies to a neuronal antigen. In this observational study, we used clinical and video polysomnography to identify a novel sleep disorder in three patients referred to the Sleep Unit of...

Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungun...
https://doi.org/10.1016/S1473-3099(15)70043-5
The Lancet. Infectious Diseases; Ramsauer K, Schwameis M et. al.

Mar 5th, 2015 - Chikungunya is an emerging arthropod-borne disease that has spread from tropical endemic areas to more temperate climates of the USA and Europe. However, no specific treatment or preventive measure is yet available. We aimed to investigate the immunogenicity and safety of a live recombinant measles-virus-based chikungunya vaccine. We did a randomised, double-blind, placebo-controlled, active-co...

Antimicrobials increase travelers' risk of colonization by extended-spectrum betalactam...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345818
Clinical Infectious Diseases : an Official Publication Of... Kantele A, Lääveri T et. al.

Jan 23rd, 2015 - More than 300 million travelers visit regions with poor hygiene annually. A significant percentage of them become colonized by resistant intestinal bacteria such as extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) and may transmit the strains to others and to medical care settings when they return home. Despite the threats to global healthcare caused by an upsurge in anti...

Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia.
https://doi.org/10.1056/NEJMoa1400283
The New England Journal of Medicine; Gaudet D, Alexander VJ et. al.

Jul 29th, 2015 - Apolipoprotein C-III (APOC3) is a key regulator of plasma triglyceride levels. Elevated triglyceride levels are associated with a risk of adverse cardiovascular events and pancreatitis. ISIS 304801 is a second-generation antisense inhibitor of APOC3 synthesis. We conducted a randomized, double-blind, placebo-controlled, dose-ranging, phase 2 study to evaluate ISIS 304801 in untreated patients w...

Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy.
https://doi.org/10.1056/NEJMoa1616569
The New England Journal of Medicine; Pasi KJ, Rangarajan S et. al.

Jul 11th, 2017 - Current hemophilia treatment involves frequent intravenous infusions of clotting factors, which is associated with variable hemostatic protection, a high treatment burden, and a risk of the development of inhibitory alloantibodies. Fitusiran, an investigational RNA interference (RNAi) therapy that targets antithrombin (encoded by SERPINC1), is in development to address these and other limitatio...

Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127885
Nature Riol-Blanco L, Ordovas-Montanes J et. al.

Apr 24th, 2014 - The skin has a dual function as a barrier and a sensory interface between the body and the environment. To protect against invading pathogens, the skin harbours specialized immune cells, including dermal dendritic cells (DDCs) and interleukin (IL)-17-producing γδ T (γδT17) cells, the aberrant activation of which by IL-23 can provoke psoriasis-like inflammation. The skin is also innervated by a ...

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138053
Nature Zahreddine HA, Culjkovic-Kraljacic B et. al.

May 29th, 2014 - Drug resistance is a major hurdle in oncology. Responses of acute myeloid leukaemia (AML) patients to cytarabine (Ara-C)-based therapies are often short lived with a median overall survival of months. Therapies are under development to improve outcomes and include targeting the eukaryotic translation initiation factor (eIF4E) with its inhibitor ribavirin. In a Phase II clinical trial in poor pr...

Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126858
Nature Whitney JB, Hill AL et. al.

Jul 21st, 2014 - The viral reservoir represents a critical challenge for human immunodeficiency virus type 1 (HIV-1) eradication strategies. However, it remains unclear when and where the viral reservoir is seeded during acute infection and the extent to which it is susceptible to early antiretroviral therapy (ART). Here we show that the viral reservoir is seeded rapidly after mucosal simian immunodeficiency vi...

Survival outcome of weak estrogen/progesterone receptor expression in HER2 negative bre...
https://doi.org/10.1016/j.ejso.2017.07.001
European Journal of Surgical Oncology : the Journal of Th... Liao GS, Dai MS et. al.

Aug 1st, 2017 - Recent publications have suggested that human epidermal growth factor receptor 2 (HER2)-negative breast cancers with "weak" estrogen receptor (ER)/progesterone receptor (PR) expression levels by immunohistochemical (IHC) analysis were considered as the triple-negative (TN) subtype. This study aimed to evaluate the overall survival (OS), disease-free survival rates (DFS), and disease-specific su...

High levels of serum CA15-3 and residual invasive tumor size are associated with poor p...
https://doi.org/10.1002/jso.25125
Journal of Surgical Oncology; Fujimoto Y, Higuchi T et. al.

Jun 24th, 2018 - To identify surrogate markers for prognosis of breast cancer patients with non-pathological complete response (non-pCR) to neoadjuvant chemotherapy (NAC), our investigation focused on the serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA15-3) as well as clinicopathological factors both before and after NAC. A total of 185 breast cancer patients treated with NAC were re...

Impact of 70-Gene Signature Use on Adjuvant Chemotherapy Decisions in Patients With Est...
https://doi.org/10.1200/JCO.2016.70.3959
Journal of Clinical Oncology : Official Journal of the Am... Kuijer A, Straver M et. al.

Aug 16th, 2017 - Purpose Gene-expression profiles increasingly are used in addition to conventional prognostic factors to guide adjuvant chemotherapy (CT) decisions. The Dutch guideline suggests use of validated gene-expression profiles in patients with estrogen receptor (ER) -positive, early-stage breast cancer without overt lymph node metastases. We aimed to assess the impact of a 70-gene signature (70-GS) te...

Tumor programmed cell death ligand 1 expression correlates with nodal metastasis in pat...
https://doi.org/10.1016/j.jaad.2017.05.047
Journal of the American Academy of Dermatology; García-Pedrero JM, Martínez-Camblor P et. al.

Jul 18th, 2017 - Binding of tumor-expressed programmed cell death ligand 1 (PD-L1) to the programmed cell death 1 (PD-1) surface receptor blocks T-cell activation thereby leading to immune evasion. Tumor PD-L1 expression has been associated with poor outcome in a wide variety of cancers; however, data in cutaneous squamous cell carcinoma (cSCC) are scarce and conflicting. To investigate the relationship of tumo...

The prognostic impact of cancer stem-like cell biomarker aldehyde dehydrogenase-1 (ALDH...
https://doi.org/10.1016/j.ygyno.2018.05.006
Gynecologic Oncology; Ruscito I, Darb-Esfahani S et. al.

May 13th, 2018 - To investigate the association of cancer stem cell biomarker aldehyde dehydrogenase-1 (ALDH1) with ovarian cancer patients' prognosis and clinico-pathological characteristics. The electronic searches were performed in January 2018 through the databases PubMed, MEDLINE and Scopus by searching the terms: "ovarian cancer" AND "immunohistochemistry" AND ["aldehyde dehydrogenase-1" OR "ALDH1" OR "ca...

Expression pattern of heat shock protein 90 in patients with oral squamous cell carcino...
https://doi.org/10.1016/j.bjoms.2017.01.008
The British Journal of Oral & Maxillofacial Surgery; Chang WC, Tsai PT et. al.

Feb 17th, 2017 - Heat shock protein 90 (HSP90), which is expressed in cancer cells, profoundly affects progression, invasion, and metastasis. However, to our knowledge, in East Asia, the correlation between the expression of HSP90 and clinicopathological variables has seldom been discussed. We therefore investigated this and its prognostic value in 36 patients newly diagnosed with oral squamous cell carcinoma (...

Serum low-density lipoprotein and low-density lipoprotein expression level at diagnosis...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391547
BMC Cancer; Zhou T, Zhan J et. al.

Apr 15th, 2017 - Patients with small-cell lung cancer (SCLC) patients demonstrate varied survival outcomes. Previous studies have reported that lipoproteins are associated with prognosis in various cancers; however, the role of low-density lipoprotein (LDL) and low-density lipoprotein- cholesterol (LDLR) in patients with SCLC has not been studied. In this study, the impact of LDL and LDLR on the prognosis of SC...

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150021
Nature Huber KV, Salah E et. al.

Apr 3rd, 2014 - Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used to identify experimental small molecules, such as SCH51344, but their molecular mechanism of action remains generally unknown. Here, using a chemical proteomic approach, we identify the target of SCH51344 as the human mutT homologue MTH1...

Development of a prognostic genetic signature to predict the metastatic risk associated...
https://doi.org/10.1158/1078-0432.CCR-13-3316
Clinical Cancer Research : an Official Journal of the Ame... Gerami P, Cook RW et. al.

Jan 7th, 2015 - The development of a genetic signature for the identification of high-risk cutaneous melanoma tumors would provide a valuable prognostic tool with value for stage I and II patients who represent a remarkably heterogeneous group with a 3% to 55% chance of disease progression and death 5 years from diagnosis. A prognostic 28-gene signature was identified by analysis of microarray expression data....

Phase 2 trial of everolimus and letrozole in relapsed estrogen receptor-positive high-g...
https://doi.org/10.1016/j.ygyno.2017.04.020
Gynecologic Oncology; Colon-Otero G, Weroha SJ et. al.

May 3rd, 2017 - We report the results of a phase 2 clinical trial of the combination of everolimus and letrozole in patients with relapsed estrogen receptor-positive high-grade ovarian cancer. The trial's primary endpoint was the proportion of patients alive and progression-free after 12weeks of therapy with the combination of everolimus and letrozole. A 12-week PFS of 45% or greater was considered a positive ...

Prediction of autism by translation and immune/inflammation coexpressed genes in toddle...
https://doi.org/10.1001/jamapsychiatry.2014.3008
JAMA Psychiatry; Pramparo T, Pierce K et. al.

Mar 4th, 2015 - The identification of genomic signatures that aid early identification of individuals at risk for autism spectrum disorder (ASD) in the toddler period remains a major challenge because of the genetic and phenotypic heterogeneity of the disorder. Generally, ASD is not diagnosed before the fourth to fifth birthday. To apply a functional genomic approach to identify a biologically relevant signatu...

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769922
Nature Cell Biology; Costa-Silva B, Aiello NM et. al.

May 19th, 2015 - Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular communication is critical for metastatic progression. Here, we show that PDAC-derived exosomes induce liver pre-metastatic niche formation in naive mice and consequently increase liver metastatic burden. Uptake of PDAC-derived exosomes by Kupff...