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About 255,823 results

Clinicopathological Significance of AKT1 and PLK1 Expression in Oral Squamous Cell Carc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232379
Disease Markers; Sun EC, Dong SS et. al.

Jun 28th, 2022 - Oral squamous cell carcinoma (OSCC) is the sixth leading cause of cancer-related death worldwide and is characterized by metastasis and recurrence. We aimed to evaluate the expression of AKT1 and PLK1 in OSCC and identify their correlation with the clinical and histological features and prognosis of patients with OSCC. Tissue samples were collected from 70 patients with OSCC and 50 patients wit...

Highly Expressing SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Ce...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232322
Journal of Immunology Research; Jumai K, Zhang T et. al.

Jun 28th, 2022 - Thrombospondin type 1 domain-containing 7A (THSD7A) was reported to play a procancer role in esophageal squamous cell carcinoma (ESCC). The aim of the study was to screen the downstream functional genes of THSD7A and explore their functions in ESCC, based on the reported research into THSD7A function and on gene microarrays. We adopted quantitative reverse-transcription polymerase chain reactio...

L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible express...
https://doi.org/10.1136/jitc-2021-003957
Journal for Immunotherapy of Cancer; Huang J, Wang X et. al.

Jun 22nd, 2022 - The repression or downregulation of programmed death-ligand 1 (PD-L1) can release its inhibition of T cells and activate antitumor immune responses. Although PD-1 and PD-L1 antibodies are promising treatments for diverse tumor types, their inherent disadvantages and immune-related adverse events remain significant issues. The development of small molecule inhibitors targeting the interaction su...

E2F2 enhances the chemoresistance of pancreatic cancer to gemcitabine by regulating the...
https://doi.org/10.1007/s12032-022-01715-x 10.3322/caac.21551 10.1002/jso.23213 10.1016/S0140-6736(10)62307-0 10.1056/NEJMra0901557 10.1016/j.gtc.2011.12.004 10.1097/00001622-199807000-00014 10.1016/j.ejphar.2014.07.041 10.1634/theoncologist.2007-0215 10.1016/S1368-7646(02)00002-X 10.1200/JCO.1997.15.6.2403 10.1016/j.drup.2006.02.002 10.1101/gad.864201 10.1016/j.febslet.2012.08.023 10.18632/aging.101441 10.4103/1319-3767.166206 10.1371/journal.pone.0010147 10.1007/s10529-014-1715-y 10.1158/0008-5472.CAN-14-2173 10.1038/s41568-018-0008-5 10.1038/sj.onc.1207272 10.1371/journal.pone.0053436 10.1038/bjc.2013.817 10.1111/cpr.12456 10.1002/jcb.24652 10.18632/oncotarget.5128 10.1038/nrgastro.2010.188 10.1097/MPA.0b013e31826c6aee 10.1200/JCO.2012.43.3680 10.1016/j.canlet.2012.03.007 10.1200/JCO.2006.07.9525 10.1200/JCO.2010.28.1386 10.1016/S1470-2045(11)70004-3 10.1200/JCO.2009.25.7550 10.1093/annonc/mds135 10.3390/cells9071643 10.1038/nature09515
Medical Oncology (Northwood, London, England); Liu Q, Song C et. al.

Jun 19th, 2022 - Both pro-oncogenic and anti-oncogenic effects of E2F2 have been revealed in different malignancies. However, the precise role of E2F2 in pancreatic cancer, in particular in relation to therapeutic intervention with gemcitabine, remains unclear. In this study, the effect of E2F2 on the proliferation and cell cycle modulation of pancreatic cancer cells, and whether E2F2 plays a role in the treatm...

Investigation of BRCAness associated miRNA-gene axes in breast cancer: cell-free miR-18...
https://doi.org/10.1186/s12885-022-09761-4 10.1155/2014/469251 10.1158/1078-0432.CCR-06-3045 10.2217/imt-2020-0283 10.1155/2013/747318 10.1186/s13073-018-0612-8 10.1038/bjc.2013.144 10.1007/s11523-021-00796-4 10.1371/journal.pone.0167016 10.1056/NEJMoa2105215 10.1016/j.bulcan.2020.11.007 10.1111/cas.14313 10.1038/nm.4292 10.7554/eLife.02445 10.1186/s12935-021-02015-6 10.2174/1389202921666191217095017 10.3390/molecules23112789 10.4161/cc.23051 10.1016/j.breast.2019.02.007 10.1155/2014/820248 10.1007/s12094-013-1058-5 10.1038/nrc1457 10.3390/jcm8040435 10.1016/j.ccell.2019.10.012 10.18632/oncotarget.10345 10.1007/s10689-015-9864-2 10.1371/journal.pone.0030679 10.1186/s12885-017-3737-z 10.1096/fj.201800120R 10.3389/fonc.2020.526850 10.1261/rna.034926.112 10.3349/ymj.2019.60.2.148 10.1016/j.molcel.2010.12.005 10.1002/emmm.201100136 10.3233/CBM-150545 10.18632/oncotarget.7705 10.5603/GP.a2017.0097 10.1093/jb/mvz079 10.1371/journal.pone.0242190 10.1371/journal.pone.0111877 10.1007/s11033-014-3140-7 10.1245/s10434-015-4754-2 10.1001/jamaoncol.2015.2690 10.1158/0008-5472.CAN-19-1991 10.1038/ng.569 10.1001/jamaoncol.2017.0424 10.1093/jnci/djy106 10.1038/s41467-017-00921-w 10.1016/j.cell.2013.03.043
BMC Cancer; Darbeheshti F, Kadkhoda S et. al.

Jun 18th, 2022 - The concept of the 'BRCAness' phenotype implies the properties that some sporadic breast cancers (BC) share with BRCA1/2-mutation carriers with hereditary BC. Breast tumors with BRCAness have deficiencies in homologous recombination repair (HRR), like BRCA1/2-mutation carriers, and consequently could benefit from poly-(ADP)-ribose polymerase (PARP) inhibitors and DNA-damaging chemotherapy. Trip...

Hypermethylation of TMEM240 predicts poor hormone therapy response and disease progress...
https://doi.org/10.1186/s10020-022-00474-9 10.4048/jbc.2016.19.3.223 10.3389/fonc.2019.00622 10.1002/ijc.28768 10.1155/2014/513158 10.1038/s41467-021-25661-w 10.3322/caac.21492 10.1186/s13148-020-00855-z 10.3390/ijms20174269 10.1038/72785 10.1056/NEJMoa1213261 10.1093/brain/awu202 10.3322/caac.21583 10.1016/j.cca.2010.08.039 10.3390/ijms19103096 10.1016/j.molonc.2010.04.002 10.1172/JCI45014 10.1007/s13277-016-5190-z 10.1007/978-3-319-22909-6_5 10.1186/gb-2011-12-4-r41 10.1016/j.annonc.2019.11.014 10.4161/epi.25577 10.1007/s00438-018-1488-4 10.1016/j.nbd.2018.08.022 10.1093/carcin/bgp220 10.1016/j.parkreldis.2018.11.027 10.1055/a-0897-6457 10.1038/nrc.2017.7 10.3390/cancers13061375 10.1158/0008-5472.CAN-03-3852 10.1007/s12311-018-0941-6 10.1016/S1470-2045(09)70262-1 10.1038/srep19897 10.1007/s11684-020-0795-4
Molecular Medicine (Cambridge, Mass.); Lin RK, Su CM et. al.

Jun 18th, 2022 - Approximately 25% of patients with early-stage breast cancer experience cancer progression throughout the disease course. Alterations in TMEM240 in breast cancer were identified and investigated to monitor treatment response and disease progression. Circulating methylated TMEM240 in the plasma of breast cancer patients was used to monitor treatment response and disease progression. The Cancer G...

SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesis.
https://doi.org/10.1073/pnas.2122897119
Proceedings of the National Academy of Sciences of the Un... Qin C, Rao Y et. al.

Jun 15th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolves rapidly under the pressure of host immunity, as evidenced by waves of emerging variants despite effective vaccinations, highlighting the need for complementing antivirals. We report that targeting a pyrimidine synthesis enzyme restores inflammatory response and depletes the nucleotide pool to impede SARS-CoV-2 infection. SARS-...

Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits.
https://doi.org/10.1084/jem.20212391
The Journal of Experimental Medicine; Whyte CE, Singh K et. al.

Jun 15th, 2022 - Interleukin 2 (IL-2) is a key homeostatic cytokine, with therapeutic applications in both immunogenic and tolerogenic immune modulation. Clinical use has been hampered by pleiotropic functionality and widespread receptor expression, with unexpected adverse events. Here, we developed a novel mouse strain to divert IL-2 production, allowing identification of contextual outcomes. Network analysis ...

Synonymous mutations in representative yeast genes are mostly strongly non-neutral.
https://doi.org/10.1038/s41586-022-04823-w 10.1017/S0016672300011459 10.1126/science.164.3881.788 10.1146/annurev.genet.42.110807.091442 10.1038/nrg1770 10.1038/nrg2899 10.1126/science.1243490 10.1073/pnas.1215033110 10.1016/j.cell.2015.02.029 10.1093/molbev/msx229 10.1126/science.1170160 10.1371/journal.pgen.1002603 10.1073/pnas.1719375115 10.1093/genetics/136.3.927 10.1016/j.molcel.2016.01.008 10.1073/pnas.1907126117 10.1038/ejhg.2011.258 10.1093/molbev/mss273 10.1371/journal.pgen.1007615 10.7554/eLife.45952 10.1126/science.1194617 10.1016/j.cell.2018.08.057 10.1016/j.cell.2017.12.015 10.1016/j.celrep.2012.09.017 10.1126/science.aae0568 10.1093/molbev/msab073 10.1016/j.cell.2016.07.024 10.1146/annurev.biochem.76.050106.093909 10.1093/nar/gkz859 10.1093/nar/15.3.1281 10.1016/j.cell.2016.08.053 10.1371/journal.pbio.1001910 10.1093/nar/gkw671 10.1371/journal.pone.0020739 10.1073/pnas.62.4.1056 10.1093/genetics/81.2.403 10.1093/genetics/61.3.763 10.7554/eLife.53810 10.1371/journal.pgen.1007419 10.1038/s41559-020-1107-8 10.7554/eLife.69549 10.1146/annurev-genet-120116-024656 10.1038/nrg3950 10.1038/s41559-021-01578-x 10.1038/nrg3051 10.1016/j.cell.2013.02.014 10.1016/j.molcel.2017.11.002 10.1002/yea.3098 10.1073/pnas.2435976100 10.1002/j.1460-2075.1996.tb00566.x 10.1371/journal.pone.0169774 10.1093/nar/gki458 10.1093/molbev/msy159 10.1007/BF00818163 10.1093/molbev/msi101
Nature Shen X, Song S et. al.

Jun 9th, 2022 - Synonymous mutations in protein-coding genes do not alter protein sequences and are thus generally presumed to be neutral or nearly neutral1-5. Here, to experimentally verify this presumption, we constructed 8,341 yeast mutants each carrying a synonymous, nonsynonymous or nonsense mutation in one of 21 endogenous genes with diverse functions and expression levels and measured their fitness rela...

Fibroblast growth factor-9 expression in airway epithelial cells amplifies the type I i...
https://doi.org/10.1371/journal.ppat.1010228
PLoS Pathogens; Hiller BE, Yin Y et. al.

Jun 9th, 2022 - Influenza A virus (IAV) preferentially infects conducting airway and alveolar epithelial cells in the lung. The outcome of these infections is impacted by the host response, including the production of various cytokines, chemokines, and growth factors. Fibroblast growth factor-9 (FGF9) is required for lung development, can display antiviral activity in vitro, and is upregulated in asymptomatic ...

Pregnancy enables antibody protection against intracellular infection.
https://doi.org/10.1038/s41586-022-04816-9 10.3109/10408417909101177 10.1093/infdis/123.4.439 10.3389/fimmu.2020.00555 10.1016/j.mib.2011.11.006 10.1038/nature09115 10.3389/fimmu.2018.02235 10.1111/imr.12344 10.1126/science.aaz9447 10.1111/cmi.13175 10.1038/nrmicro.2017.126 10.1016/S1473-3099(17)30229-3 10.4049/immunohorizons.1700057 10.1084/jem.164.1.363 10.1128/iai.56.8.1920-1925.1988 10.1111/imr.12350 10.1111/j.1749-6632.2011.06305.x 10.4049/jimmunol.1502136 10.1007/s000180050258 10.1016/j.celrep.2015.05.044 10.1016/S0021-9258(17)39429-2 10.1038/nri2056 10.1038/s41589-018-0034-3 10.1016/j.placenta.2010.11.014 10.1021/ac504725r 10.1083/jcb.126.2.549 10.1074/jbc.M304331200 10.1074/jbc.275.12.8633 10.4049/jimmunol.1401329 10.1016/j.immuni.2008.03.017 10.4049/jimmunol.1201427 10.4049/jimmunol.1201247 10.1016/j.immuni.2019.05.011 10.1128/IAI.72.4.2131-2139.2004 10.1182/blood-2009-12-261461 10.1002/eji.201141899 10.1073/pnas.1304888110 10.1159/000322375 10.1016/j.coi.2018.04.011 10.1007/s002510050494 10.1021/acschembio.7b00952 10.1016/0092-8674(91)90408-Q 10.1038/s41586-022-04471-0 10.1056/NEJM199203053261003 10.1056/NEJM200105033441804 10.1001/jama.289.2.203 10.1038/s41467-021-27069-y 10.1073/pnas.95.8.4504 10.1186/s13059-016-1012-2 10.4049/jimmunol.171.2.533 10.1038/nature12675 10.1016/j.chom.2019.02.004 10.1371/journal.ppat.1006684 10.1128/mSphere.00379-16
Nature Erickson JJ, Archer-Hartmann S et. al.

Jun 9th, 2022 - Adaptive immune components are thought to exert non-overlapping roles in antimicrobial host defence, with antibodies targeting pathogens in the extracellular environment and T cells eliminating infection inside cells1,2. Reliance on antibodies for vertically transferred immunity from mothers to babies may explain neonatal susceptibility to intracellular infections3,4. Here we show that pregnanc...

Biotropic liquid crystal phase transformations in cellulose-producing bacterial communi...
https://doi.org/10.1073/pnas.2200930119
Proceedings of the National Academy of Sciences of the Un... Repula A, Abraham E et. al.

Jun 8th, 2022 - Biological functionality is often enabled by a fascinating variety of physical phenomena that emerge from orientational order of building blocks, a defining property of nematic liquid crystals that is also pervasive in nature. Out-of-equilibrium, "living" analogs of these technological materials are found in biological embodiments ranging from myelin sheath of neurons to extracellular matrices ...

TNF-α/IFN-γ synergy amplifies senescence-associated inflammation and SARS-CoV-2 recepto...
https://doi.org/10.1111/acel.13646
Aging Cell; Kandhaya-Pillai R, Yang X et. al.

Jun 2nd, 2022 - Older age and underlying conditions such as diabetes/obesity or immunosuppression are leading host risk factors for developing severe complications from COVID-19 infection. The pathogenesis of COVID-19-related cytokine storm, tissue damage, and fibrosis may be interconnected with fundamental aging processes, including dysregulated immune responses and cellular senescence. Here, we examined effe...

Elevated prohibitin 1 expression mitigates glucose metabolism defects in granulosa cell...
https://doi.org/10.1093/molehr/gaac018
Molecular Human Reproduction; Mao J, Zhang J et. al.

Jun 1st, 2022 - Endometriosis is a common disease in women of childbearing age and is closely associated with female infertility. However, the pathogenesis of endometriosis-related infertility is still not fully understood. Prohibitin 1 (PHB1), a highly conserved protein related to mitochondrial function, is differentially expressed in the endometrium of patients with endometriosis. However, the role of PHB1 i...

Molecular mechanisms involved in pre-eclampsia through expressional regulation of endot...
https://doi.org/10.1016/j.placenta.2022.05.012
Placenta Simsek F, Turunc E et. al.

Jun 1st, 2022 - Preeclampsia (PE) is a condition affecting 2-8% of all pregnancies and is a leading cause of perinatal morbidity and mortality. In our study; we aim to investigate the differences in endothelin-1 (ET-1) at both tissue and blood level in the placenta, umbilical cord, and maternal blood obtained from different experimental groups and the changes in the contraction response of umbilical arteries i...

Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy.
https://doi.org/10.1056/NEJMoa2119771
The New England Journal of Medicine; Liu YC, Kwon J et. al.

May 26th, 2022 - Although hypomethylating agents are currently used to treat patients with cancer, whether they can also reactivate and up-regulate oncogenes is not well elucidated. We examined the effect of hypomethylating agents on SALL4, a known oncogene that plays an important role in myelodysplastic syndrome and other cancers. Paired bone marrow samples that were obtained from two cohorts of patients with ...

HMGB1 mediates invasion and PD-L1 expression through RAGE-PI3K/AKT signaling pathway in...
https://doi.org/10.1186/s12885-022-09675-1 10.1007/s10549-020-05561-1 10.1016/j.bbamcr.2012.10.021 10.1016/j.clbc.2017.04.007 10.1016/j.mam.2014.05.001 10.3892/ol.2015.3843 10.1007/s11010-014-1978-6 10.1038/onc.2016.324 10.1007/s10549-019-05130-1 10.1158/0008-5472.CAN-19-2862 10.1359/jbmr.2001.16.8.1486 10.7150/jca.48327 10.1016/j.ymthe.2006.05.022 10.1007/s10565-008-9054-1 10.1186/s13045-020-00950-x 10.1016/j.canlet.2016.02.005 10.12659/MSM.915690 10.1097/CAD.0000000000000705 10.3390/ijms22158153 10.1186/1741-7007-10-29 10.1023/A:1014594825502 10.1186/1471-2407-14-955 10.4161/auto.6.8.13367 10.18632/oncotarget.1908 10.1016/j.bbadis.2014.12.009 10.1007/s10456-008-9093-5 10.1007/s13277-015-4049-z 10.1093/carcin/bgr101 10.1158/1078-0432.CCR-11-3313 10.1038/s41598-017-14216-z 10.1371/journal.pone.0065821 10.1158/0008-5472.CAN-18-3134
BMC Cancer; Amornsupak K, Thongchot S et. al.

May 25th, 2022 - High-mobility group box 1 (HMGB1) is increased in breast cancer cells as the result of exposure to the secreted substances from cancer-associated fibroblasts and plays a crucial role in cancer progression and drug resistance. Its effect, however, on the expression of programmed death ligand 1 (PD-L1) in breast cancer cells has not been investigated. This study aimed to investigate the mechanism...

Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetop...
https://doi.org/10.1186/s12916-022-02391-4 10.1016/j.molcel.2019.03.011 10.1128/MCB.21.13.4330-4336.2001 10.1074/jbc.M116.765800 10.1007/s00018-018-2918-5 10.1111/j.1469-7580.2008.01035.x 10.1038/nrc3215 10.1210/er.2008-0028 10.1002/clc.4960020506 10.1016/j.beem.2015.06.003 10.1074/jbc.M002172200 10.1006/bbrc.2000.3835 10.1210/endo.141.2.7292 10.1210/jcem-71-4-806 10.1002/pd.1480 10.1159/000275669 10.1080/14767050701483389 10.1016/S1043-2760(03)00049-3 10.1210/jcem-71-4-797 10.1016/j.aanat.2010.12.002 10.1210/mend.11.4.9904 10.1074/jbc.M111884200 10.1101/gad.11.2.179 10.3389/fimmu.2020.01038 10.1126/scisignal.aac6160 10.1126/scisignal.aac6151 10.1007/s12079-015-0259-9 10.1210/jcem.87.5.8448 10.1210/jc.2018-00820 10.1016/0167-0115(95)00155-7 10.1038/s41467-018-04992-1 10.1073/pnas.1008831108 10.3892/or.2015.4317 10.1016/0002-9378(73)90591-7 10.1016/0002-9378(83)90249-1 10.1210/jcem-58-2-344 10.1016/0002-9378(87)90086-X 10.1016/S0021-9258(18)89651-X 10.1111/j.1748-1716.1990.tb08842.x 10.1210/endo.140.9.6993 10.1071/RD9951465 10.1371/journal.pone.0178269
BMC Medicine; Zhu YN, Gan XW et. al.

May 25th, 2022 - Enhancer of zeste homolog 2 (EZH2)-mediated histone 3 lysine 27 trimethylation (H3K27me3) is a transcription silencing mark, which is indispensable for cell lineage specification at the early blastocyst stage. This epigenetic repression is maintained in placental cytotrophoblasts but is lifted when cytotrophoblasts differentiate into syncytiotrophoblasts. However, the physiological impact of th...

Glyceryl butyrate attenuates enterotoxigenic Escherichia coli-induced intestinal inflam...
https://doi.org/10.1039/d2fo01056a
Food & Function; Tian M, Li L et. al.

May 25th, 2022 - The aims of this study were to evaluate whether a diet supplemented with glyceryl butyrate could attenuate the immune-inflammatory response in piglets challenged with enterotoxigenic Escherichia coli (ETEC), and to explore the mechanisms of its regulation. Eighteen weaning piglets were assigned to three diets: basal diet (CON), antibiotics diet (ATB), and 0.5% glyceryl butyrate diet (GB group)....

MRTF-A-mediated protection against amyloid-β-induced neuronal injury correlates with re...
https://doi.org/10.18632/aging.203883
Aging Zhang W, Yang Y et. al.

May 24th, 2022 - Myocardia-Related Transcription Factors-A (MRTF-A), which is enriched in the hippocampus and cerebral cortex, has been shown to have a protective function against ischemia hypoxia-induced neuronal apoptosis. However, the function of MRTF-A on β-amyloid peptide (Aβ)-induced neurotoxicity and autophagy dysfunction in Alzheimer's disease is still unclear. This study shows that the expression of MR...