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About 250,383 results

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vacc...
https://doi.org/10.1073/pnas.2106433118
Proceedings of the National Academy of Sciences of the Un... King HAD, Joyce MG et. al.

Sep 3rd, 2021 - Emergence of novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need for next-generation vaccines able to elicit broad and durable immunity. Here we report the evaluation of a ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein (RFN) adjuvanted with Army Liposomal Formulation QS-21 (ALFQ). RFN vacci...

AACC Practical Recommendations for Implementing and Interpreting SARS-CoV-2 Emergency U...
https://doi.org/10.1093/clinchem/hvab051
Clinical Chemistry; Zhang YV, Wiencek J et. al.

Sep 2nd, 2021 - The clinical laboratory continues to play a critical role in managing the coronavirus pandemic. Numerous US Food and Drug Administration emergency use authorization (EUA) and laboratory-developed test (LDT) serologic assays have become available. The performance characteristics of these assays and their clinical utility continue to be defined in real time during this pandemic. The AACC convened...

Expression of mammalian sterile 20-like kinase 1 and 2 and Yes-associated protein 1 pro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389968
Medicine Feng Y, Ci H et. al.

Aug 28th, 2021 - Mammalian sterile 20-like kinase 1 and 2 (MST1/2) and Yes-associated protein 1 (YAP1) are the core molecules of the Hippo signaling pathway, which have been found to be unbalanced in the occurrence of tumors and promote the development of the lesions. The present study aimed to investigate the expression of MST1/2 and YAP1 proteins in triple-negative breast cancer (TNBC) and their clinicopathol...

The predictive and prognostic effects of PD-L1 expression on TKI treatment and survival...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389972
Medicine Lan B, Wang Y et. al.

Aug 28th, 2021 - Whether programmed death-ligand 1 (PD-L1) expression could predict the outcome of tyrosine kinase inhibitor (TKI) treatment and prognosis of epidermal growth factor receptor (EGFR)-mutant nonsmall cell lung cancer (NSCLC) is remaining controversial.Potential studies were search from PubMed, Embase, and Web of Science databases. Pooled odds ratio of objective response rate was used to describe t...

Prognostic values and clinical relationship of TYK2 in laryngeal squamous cell cancer.
https://doi.org/10.1097/MD.0000000000027062
Medicine Fang L, Wang W et. al.

Aug 28th, 2021 - Laryngeal squamous cell cancer (LSCC) is the second most common head and neck cancer with the increasing mortality. The tyrosine kinase 2 (TYK2) has previously been reported to play an important role in various cancers excepting LSCC. We used available data from the cancer genome atlas program (TCGA), gene expression omnibus, and gene expression profiling interactive analysis (GEPIA) to evaluat...

The co-expression of CBX8 and PD-L1 and prognostic value in cervical cancer.
https://doi.org/10.1097/MD.0000000000027056
Medicine Zhou H, Li A et. al.

Aug 28th, 2021 - Chromobox homolog 8 (CBX8) plays an important role in the occurrence and development of various tumors, and is closely related to the prognosis of patients with cancer. However, the occurrence, development, and prognostic value of CBX8 in cervical cancer have not been reported yet.In this study, immunohistochemistry was used to detect the expression of CBX8 in cervical cancer tissues and the co...

Biology and applications of co-produced, synergistic antimicrobials from environmental ...
https://doi.org/10.1038/s41564-021-00952-6 10.1039/C7NP00019G 10.1021/cb200337h 10.1093/femsre/fux005 10.1007/s10295-015-1686-6 10.1073/pnas.1934677100 10.1128/AEM.02863-07 10.1016/j.chembiol.2015.03.010 10.1016/j.cell.2014.06.034 10.1007/s10295-016-1815-x 10.1128/mBio.00416-20 10.1016/j.tig.2010.07.001 10.1073/pnas.0709132105 10.1046/j.1365-2958.2000.02098.x 10.1016/j.ijmm.2013.08.008 10.1128/mr.43.2.145-192.1979 10.1080/14787210.2021.1834851 10.1186/1741-7007-2-4 10.1111/j.1751-7915.2010.00213.x 10.1016/j.gene.2006.12.035 10.1046/j.1365-2958.2000.01819.x 10.1046/j.1365-2958.2003.03523.x 10.1073/pnas.0914100107 10.1073/pnas.1019406108 10.1128/JB.01383-07 10.1074/jbc.RA118.005314 10.1146/annurev-micro-022618-042458 10.7164/antibiotics.35.1400 10.1016/S0021-9258(19)88662-3 10.1021/acsinfecdis.8b00105 10.1021/acschembio.7b00687 10.1016/j.chembiol.2017.08.024 10.1038/s41467-018-03447-x 10.1021/jacs.8b02283 10.1073/pnas.0806261105 10.1007/978-1-4939-2398-4_4 10.1111/j.1365-2958.2006.05223.x 10.1039/C2NP20085F 10.1021/bi0362065 10.1046/j.1365-2958.1996.831449.x 10.1021/ja206281k 10.1073/pnas.0913554107 10.3389/fmicb.2017.00696 10.1007/s12602-009-9021-z 10.1016/S1367-5931(99)00025-3 10.1016/S0300-9084(02)01414-1 10.1016/j.bmc.2018.03.022 10.7164/antibiotics.45.1451 10.3389/fmicb.2020.578878 10.1146/annurev-micro-090816-093420 10.1128/AAC.11.5.852 10.1023/A:1001755724055 10.1186/1471-2164-15-970 10.1007/s10295-012-1191-0 10.7164/antibiotics.30.770 10.7164/antibiotics.32.295 10.1002/cbic.201300319 10.1016/j.chembiol.2016.12.012 10.1016/j.chembiol.2017.09.001 10.1016/j.jmb.2019.06.033 10.1038/nchembio.2376 10.1073/pnas.1721790115 10.1073/pnas.1510432112 10.1038/s41467-018-02875-z 10.1016/S0014-827X(01)01002-3 10.1038/s41598-020-64756-0 10.1073/pnas.0911237107 10.1038/srep40294 10.1074/jbc.H118.006669 10.1093/nar/gkz310 10.1038/nchembio0707-353 10.1073/pnas.0914343107 10.1038/srep14720 10.1186/s12864-020-06785-7 10.1016/j.chembiol.2015.11.014 10.1021/jacs.8b09328 10.3390/md13116910 10.1038/s41579-018-0141-x 10.1128/CMR.00037-09 10.1039/C9NP00011A 10.1038/nbt.3597 10.1039/C9NP00025A 10.1038/s41579-018-0075-3
Nature Microbiology; Meyer KJ, Nodwell JR

Aug 28th, 2021 - Environmental bacteria, such as Streptomyces spp., produce specialized metabolites that are potent antibiotics and therapeutics. Selected specialized antimicrobials are co-produced and function together synergistically. Co-produced antimicrobials comprise multiple chemical classes and are produced by a wide variety of bacteria in different environmental niches, suggesting that their combined fu...

MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition ident...
https://doi.org/10.1038/s41467-021-25325-9 10.1186/1755-8794-3-8 10.1038/35094009 10.1158/0008-5472.CAN-08-0249 10.1158/0008-5472.CAN-07-5997 10.1158/0008-5472.CAN-11-0532 10.1002/pros.21072 10.1016/j.mce.2008.08.013 10.1158/1078-0432.CCR-17-0989 10.1016/j.cell.2013.11.012 10.1056/NEJMoa1014618 10.1056/NEJMoa1207506 10.1038/nrc4016 10.1016/j.plipres.2020.101033 10.1158/0008-5472.CAN-16-0903 10.1093/carcin/bgx058 10.3390/ijms141121414 10.1158/0008-5472.CAN-08-2894 10.1038/cddis.2010.85 10.1371/journal.pone.0076994 10.1038/bjc.2013.131 10.1002/cncr.25488 10.1038/onc.2012.300 10.1073/pnas.1110977109 10.1158/0008-5472.CAN-13-1606 10.1158/0008-5472.CAN-08-0144 10.1016/j.devcel.2019.03.012 10.1038/ncb1722 10.1128/AAC.27.2.252 10.1158/0008-5472.CAN-18-2529 10.1146/annurev.cellbio.22.010305.104656 10.1038/s41467-018-07959-4 10.1038/s41467-018-07928-x 10.1002/(SICI)1097-0215(19980911)77:6<887::AID-IJC15>3.0.CO;2-Z 10.1126/scitranslmed.aap9840 10.1038/s41586-019-0945-5 10.1371/journal.pone.0177861 10.1111/j.1444-0903.2004.00541.x 10.1172/JCI128212 10.1038/s41467-018-06067-7 10.1016/j.ccell.2017.09.003 10.1038/s41416-018-0172-0 10.1038/76287 10.1074/jbc.M203313200 10.1016/j.cmet.2011.01.015 10.1038/srep19435 10.1016/S0092-8674(00)80213-5 10.1210/en.2015-1367 10.1038/srep32611 10.1002/pros.23508 10.1038/srep33510 10.1002/pros.10290 10.1002/ijc.31901 10.3390/cancers12092639 10.1056/NEJMe1103829 10.1038/s41598-017-17204-5 10.1038/s41598-017-14759-1
Nature Communications; Kalogirou C, Linxweiler J et. al.

Aug 22nd, 2021 - Prostate cancer (PCa) shows strong dependence on the androgen receptor (AR) pathway. Here, we show that squalene epoxidase (SQLE), an enzyme of the cholesterol biosynthesis pathway, is overexpressed in advanced PCa and its expression correlates with poor survival. SQLE expression is controlled by micro-RNA 205 (miR-205), which is significantly downregulated in advanced PCa. Restoration of miR-2...

Correcting for sparsity and interdependence in glycomics by accounting for glycan biosy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371009
Nature Communications; Bao B, Kellman BP et. al.

Aug 19th, 2021 - Glycans are fundamental cellular building blocks, involved in many organismal functions. Advances in glycomics are elucidating the essential roles of glycans. Still, it remains challenging to properly analyze large glycomics datasets, since the abundance of each glycan is dependent on many other glycans that share many intermediate biosynthetic steps. Furthermore, the overlap of measured glycan...

Genome-scale target identification in Escherichia coli for high-titer production of fre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371096
Nature Communications; Fang L, Fan J et. al.

Aug 19th, 2021 - To construct a superior microbial cell factory for chemical synthesis, a major challenge is to fully exploit cellular potential by identifying and engineering beneficial gene targets in sophisticated metabolic networks. Here, we take advantage of CRISPR interference (CRISPRi) and omics analyses to systematically identify beneficial genes that can be engineered to promote free fatty acids (FFAs)...

Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis an...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360427
Medicine Wang X, Meng Q et. al.

Aug 17th, 2021 - Plenty of studies have showed matrix metalloproteinase 14 (MMP14) expression might be associated with the prognosis of gastric cancer (GC). However, no definite conclusion has been obtained for the contradictory results. We searched PubMed, Web of science, Embase, and Cochrane library for eligible studies. The association between MMP14 expression and prognostic outcomes of GC was evaluated. Haz...

Integrated bioinformatics analysis reveals CDK1 and PLK1 as potential therapeutic targe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360490
Medicine Li S, Li H et. al.

Aug 17th, 2021 - This study is to identify potential biomarkers and therapeutic targets for lung adenocarcinoma (LUAD).GSE6044 and GSE118370 raw data from the Gene Expression Omnibus database were normalized with Robust Multichip Average. After merging these two datasets, the combat function of sva packages was used to eliminate batch effects. Then, limma packages were used to filtrate differentially expressed ...

The potential value of microRNA-145 for predicting prognosis in patients with ovarian c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360411
Medicine Chen Z, Xiao Z et. al.

Aug 17th, 2021 - As an anticancer gene, microRNA-145 (miRNA-145) inhibits the growth, migration, and invasion of cancer cells, and inhibits tumorigenesis by targeting various genes that are abnormally expressed in tumors. However, whether miRNA-145 can be applied as a biomarker for potential prognosis of ovarian cancer still remains controversial. Therefore, this study further explored the prognostic value and ...

The value of Angipoietin-2 as a biomarker for the prognosis of osteosarcoma: A protocol...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360409
Medicine Liu L, Zhang X et. al.

Aug 17th, 2021 - The function of Angipoietin-2 (Agn2) in osteosarcoma has not been fully explored and exists controversial. Therefore, we conducted a meta-analysis to investigate the role of Agn2 in the prognosis of osteosarcoma. In addition, bioinformatics analysis was carried out to reveal the mechanism and related pathways of Agn2 in osteosarcoma. Literature search was operated on databases up to July 2021, ...

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357841
Nature Communications; Kremer DM, Nelson BS et. al.

Aug 13th, 2021 - Cancer metabolism is rewired to support cell survival in response to intrinsic and environmental stressors. Identification of strategies to target these adaptions is an area of active research. We previously described a cytosolic aspartate aminotransaminase (GOT1)-driven pathway in pancreatic cancer used to maintain redox balance. Here, we sought to identify metabolic dependencies following GOT...

Longitudinal analysis to characterize classes and subclasses of antibody responses to r...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354433
PloS One; Tandhavanant S, Koosakunirand S et. al.

Aug 11th, 2021 - Serological assays to detect antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might contribute to confirming the suspected coronavirus disease 2019 (COVID-19) in patients not detected with molecular assays. Human antibodies that target the host angiotensin-converting enzyme 2-binding domain of the viral spike protein are a target for serodiagnosis and therapeutics...

Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381960
Emerging Microbes & Infections; Zhang Z, Liu Q et. al.

Aug 10th, 2021 - Coronaviruses (CoVs) can infect a variety of hosts, including humans, livestock and companion animals, and pose a serious threat to human health and the economy. The current COVID-19 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has killed millions of people. Unfortunately, effective treatments for CoVs infection are still lacking, suggesting the imp...

Comparative transcriptome analysis reveals potential testosterone function-related regu...
https://doi.org/10.1016/j.gene.2021.145870
Gene Huang L, Xiao K et. al.

Aug 8th, 2021 - Leydig cells (LCs) are testosterone-generating endocrine cells that are located outside the seminiferous tubules in the testis, and testosterone is fundamental for retaining spermatogenesis and male fertility. In buffalo, adult Leydig cells (ALCs) are developed by immature Leydig cells (ILCs) in the postnatal testes. However, the genes/pathways associated to the regulation of testosterone secre...

Hemodialysis Patients Make Long-Lived Antibodies against SARS-CoV-2 that May Be Associa...
https://doi.org/10.1681/ASN.2021020188
Journal of the American Society of Nephrology : JASN; Banham GD, Godlee A et. al.

Aug 4th, 2021 - Hemodialysis Patients Make Long-Lived Antibodies against SARS-CoV-2 that May Be Associated with Reduced Reinfection.|2021|Banham GD,Godlee A,Faustini SE,Cunningham AF,Richter A,|biosynthesis,blood,epidemiology,immunology,epidemiology,epidemiology,immunology,prevention & control,immunology,immunology,

Environmentally-induced mdig contributes to the severity of COVID-19 through fostering ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315075
Theranostics Zhang Q, Wadgaonkar P et. al.

Aug 3rd, 2021 - The novel β-coronavirus, SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), has infected more than 177 million people and resulted in 3.84 million death worldwide. Recent epidemiological studies suggested that some environmental factors, such as air pollution, might be the important contributors to the mortality of COVID-19. However, how environmental exposure enhances the ...