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About 941,963 results

Prognostic Value of Serum Interleukin-6, NF-κB plus MCP-1 Assay in Patients with Diabet...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232375
Disease Markers; An Z, Qin J et. al.

Jun 28th, 2022 - To assess the prognostic value of serum interleukin-6 (IL-6), nuclear factor-κB (NF-κB), and monocyte chemoattractant protein 1(MCP-1) assay in patients with diabetic nephropathy. From May 2019 to March 2020, 104 patients with diabetic nephropathy treated in our institution assessed for eligibility were recruited and assigned at a ratio of 1 : 1 to either the observation group ([urinary albumin...

Serum IL-5, POSTN and IL-33 levels in chronic rhinosinusitis with nasal polyposis corre...
https://doi.org/10.1186/s12865-022-00507-2 10.1016/j.jaci.2018.12.986 10.2500/ajra.2013.27.3981 10.2500/108854196778662246 10.2500/ajr.2008.22.3162 10.1016/j.anai.2016.06.006 10.2500/105065800781329573 10.1159/000484527 10.1016/S1081-1206(10)62807-4 10.1086/313661 10.1016/j.jaci.2015.10.009 10.1007/s11882-015-0540-2 10.1007/s11908-011-0166-z 10.1016/j.jaci.2011.07.049 10.3390/medicina55040095 10.1128/CMR.9.4.532 10.1007/s11882-018-0776-8 10.1007/s11882-007-0073-4 10.2183/pjab.87.463 10.3389/fmed.2018.00049 10.3389/fphys.2019.01514 10.5603/FHC.a2015.0014 10.1007/s00405-020-06369-x 10.1136/thoraxjnl-2016-208772 10.2500/ajra.2010.24.3446 10.3389/fimmu.2019.00692 10.1002/eji.200737547 10.1016/S0301-0546(09)71728-8 10.4193/Rhino12.000 10.1016/S0194-5998(97)70005-6 10.3390/diagnostics11010135 10.1038/nprot.2008.73 10.1016/j.jaci.2009.05.017 10.1186/s40463-017-0214-2 10.1111/j.1398-9995.2008.01885.x 10.1016/S0091-6749(97)80019-X 10.1016/j.jaci.2006.05.031 10.2147/TCRM.S2379 10.1016/j.jaci.2011.07.056 10.1016/j.jaci.2017.05.044 10.1177/2058738420950851 10.1038/s41598-018-29612-2 10.2332/allergolint.11-OA-0370 10.1002/alr.21056 10.1177/0194599817737967 10.1002/lary.24462 10.3390/biom10111568 10.2174/1566524019666190405120137 10.11604/pamj.2014.18.40.2839 10.1002/alr.21370 10.3349/ymj.2019.60.6.578 10.1002/alr.21499 10.1186/s13601-018-0219-6 10.1177/1945892420923934
BMC Immunology; Zielińska-Bliźniewska H, Paprocka-Zjawiona M et. al.

Jun 26th, 2022 - Chronic rhinosinusitis (CRS) is a group of heterogeneous diseases characterized by epithelial inflammation and tissue eosinophilic infiltration. IL-5, POSTN, and IL-33 are important factors that act as chemoattractants for eosinophils, and a tissue-remodeling protein positively correlated with eosinophils in blood and mediators of eosinophilic infiltration. The aim of the study was to determine...

Square-Stepping Exercise Program Effects on Fall-Related Fitness and BDNF Levels in Old...
https://doi.org/10.3390/ijerph19127033
International Journal of Environmental Research and Publi... Cha HJ, Kim KB et. al.

Jun 25th, 2022 - The risk of dementia increases with age. To mitigate this risk, we examined the effect of a square-stepping exercise (SSE) program on fall-related fitness and brain-derived neurotrophic factor (BDNF) levels. Twenty older adults in Korea were randomly assigned to either the experimental or control group (each group n = 10). Participants performed SSE for 70 min per session, twice a week, for 12 ...

Circulating MMP-12 as Potential Biomarker in Evaluating Disease Severity and Efficacy o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207019
Mediators of Inflammation; Zhou Y, Xu M et. al.

Jun 24th, 2022 - Allergic rhinitis (AR) is a highly heterogeneous disease, and allergen-specific immunotherapy (AIT) is an effective treatment. This study aims to evaluate the circulating mas-related G protein-coupled receptor-X2 (MRGPRX2) and matrix metalloproteinase-12 (MMP-12) levels in evaluating disease severity and predicting efficacy of SLIT in AR patients. We enrolled 110 moderate-severe persist AR pati...

Passage of exogeneous fine particles from the lung into the brain in humans and animals.
https://doi.org/10.1073/pnas.2117083119
Proceedings of the National Academy of Sciences of the Un... Qi Y, Wei S et. al.

Jun 24th, 2022 - There are still significant knowledge gaps in understanding the intrusion and retention of exogeneous particles into the central nervous system (CNS). Here, we uncovered various exogeneous fine particles in human cerebrospinal fluids (CSFs) and identified the ambient environmental or occupational exposure sources of these particles, including commonly found particles (e.g., Fe- and Ca-containin...

Antibody and T cell responses to COVID-19 vaccination in patients receiving anticancer ...
https://doi.org/10.1136/jitc-2022-004766
Journal for Immunotherapy of Cancer; Rouhani SJ, Yu J et. al.

Jun 23rd, 2022 - Patients with cancer were excluded from phase 3 COVID-19 vaccine trials, and the immunogenicity and side effect profiles of these vaccines in this population is not well understood. Patients with cancer can be immunocompromised from chemotherapy, corticosteroids, or the cancer itself, which may affect cellular and/or humoral responses to vaccination. PD-1 is expressed on T effector cells, T fol...

The role of serum ADAMTS-1 levels in Hyperemesis Gravidarum.
https://doi.org/10.1186/s12884-022-04832-7 10.1080/14767058.2017.1342805 10.1016/j.ejogrb.2015.03.028 10.1159/000477853 10.1186/s13584-016-0099-y 10.1186/1477-7827-8-102 10.1210/endrev/bnaa007 10.1080/10641955.2017.1397690 10.5858/arpa.2012-0227-OA 10.1074/jbc.272.1.556 10.1016/j.kjms.2016.10.010 10.3389/fmed.2021.809270 10.1038/s41467-018-03258-0 10.1002/jcsm.12077 10.1093/humrep/del108 10.1016/j.domaniend.2013.04.002 10.1111/1471-0528.12132 10.1177/2284026520987915 10.1096/fj.11-191916 10.3389/fnins.2015.00390 10.1016/j.matbio.2015.01.014 10.1007/s00018-013-1279-3 10.3390/ijms21228767 10.2147/DMSO.S280851 10.1016/j.ejogrb.2020.08.014 10.1111/jog.14857
BMC Pregnancy and Childbirth; Timur B, Guney G

Jun 21st, 2022 - We aimed to investigate the levels of ADAMTS-1, which is secreted from the extracellular matrix during trophoblastic invasion in hyperemesis gravidarum (HEG). In this cross-sectional study, we compared 45 HEG patients aged between 21 and 34 in terms of ADAMTS-1 levels with a control group consisting of 44 healthy pregnant women. The demographic characteristics and several laboratory parameters ...

Hypermethylation of TMEM240 predicts poor hormone therapy response and disease progress...
https://doi.org/10.1186/s10020-022-00474-9 10.4048/jbc.2016.19.3.223 10.3389/fonc.2019.00622 10.1002/ijc.28768 10.1155/2014/513158 10.1038/s41467-021-25661-w 10.3322/caac.21492 10.1186/s13148-020-00855-z 10.3390/ijms20174269 10.1038/72785 10.1056/NEJMoa1213261 10.1093/brain/awu202 10.3322/caac.21583 10.1016/j.cca.2010.08.039 10.3390/ijms19103096 10.1016/j.molonc.2010.04.002 10.1172/JCI45014 10.1007/s13277-016-5190-z 10.1007/978-3-319-22909-6_5 10.1186/gb-2011-12-4-r41 10.1016/j.annonc.2019.11.014 10.4161/epi.25577 10.1007/s00438-018-1488-4 10.1016/j.nbd.2018.08.022 10.1093/carcin/bgp220 10.1016/j.parkreldis.2018.11.027 10.1055/a-0897-6457 10.1038/nrc.2017.7 10.3390/cancers13061375 10.1158/0008-5472.CAN-03-3852 10.1007/s12311-018-0941-6 10.1016/S1470-2045(09)70262-1 10.1038/srep19897 10.1007/s11684-020-0795-4
Molecular Medicine (Cambridge, Mass.); Lin RK, Su CM et. al.

Jun 18th, 2022 - Approximately 25% of patients with early-stage breast cancer experience cancer progression throughout the disease course. Alterations in TMEM240 in breast cancer were identified and investigated to monitor treatment response and disease progression. Circulating methylated TMEM240 in the plasma of breast cancer patients was used to monitor treatment response and disease progression. The Cancer G...

Alcohol Drinks Induce Acute Lowering in Circulating l-Arginine in Obese and Type 2 Diab...
https://doi.org/10.1089/jmf.2021.0045
Journal of Medicinal Food; Buch A, Ganz T et. al.

Jun 17th, 2022 - Since low serum l-arginine (Arg) and high asymmetric dimethylarginine (ADMA) can predict microvascular complications in type 2 diabetes mellitus (T2DM), we tested whether Arg and ADMA are affected by diet and physical activity in overweight/obese and T2DM subjects. We tested the effects on serum Arg and ADMA of single loads of dextrose, protein, fat, or alcohol (∼300 calories each); one episode...

Blood-based untargeted metabolomics in relapsing-remitting multiple sclerosis revealed ...
https://doi.org/10.1073/pnas.2123265119
Proceedings of the National Academy of Sciences of the Un... Zahoor I, Suhail H et. al.

Jun 15th, 2022 - Metabolic aberrations impact the pathogenesis of multiple sclerosis (MS) and possibly can provide clues for new treatment strategies. Using untargeted metabolomics, we measured serum metabolites from 35 patients with relapsing-remitting multiple sclerosis (RRMS) and 14 healthy age-matched controls. Of 632 known metabolites detected, 60 were significantly altered in RRMS. Bioinformatics analysis...

Plasma Complement C1q/tumor necrosis factor-related protein 15 concentration is associa...
https://doi.org/10.1371/journal.pone.0263658
PloS One; Vatannejad A, Fadaei R et. al.

Jun 15th, 2022 - Polycystic ovarian syndrome (PCOS) is a common poignant endocrine disorder affecting women, posing a close association with metabolic syndrome and obesity. Existing literature characterizes PCOS with deranged levels of several adipokines and myokines. CTRP15 is a paralogue of adiponectin, mainly expressed by skeletal muscles, and plays a key role in insulin, glucose, and lipid metabolism. In th...

Predictive Value of Monocyte Chemoattractant Protein-1 in the Development of Diastolic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187441
Disease Markers; Bursać IU, Kehler T et. al.

Jun 14th, 2022 - We aimed to evaluate the diagnostic accuracy of the proinflammatory monocyte chemotactic protein-1 (MCP-1) in the diagnosis of asymptomatic diastolic dysfunction (DD) in patients with psoriatic arthritis (PsA). The disease activity in psoriatic arthritis (DAPSA) was determined using clinical and laboratory parameters, and echocardiography was performed to estimate DD. Serum MCP-1 concentrations...

Relationship between Exercise Intensity and IL-6 Increase during an 80 km Long-Distance...
https://doi.org/10.3390/ijerph19116368
International Journal of Environmental Research and Publi... Jouffroy R, Anglicheau D et. al.

Jun 11th, 2022 - Background: IL-6 plasma concentration (IL-6PC) reflects the systemic inflammation related to exercise intensity level. This study aims to describe the IL-6PC kinetics during a long-distance running race. IL-6PC was measured in 20 male runners before (0 km), at each refreshment point (at 21 and 53 km, i.e., k21 and k53, respectively) and at the end of an 80 km long-distance run (k80). Methods: I...

Low total osteocalcin levels are associated with all-cause and cardiovascular mortality...
https://doi.org/10.1186/s12933-022-01539-z 10.1007/s11154-019-09517-9 10.1016/j.abb.2014.05.022 10.1530/EJE-09-0585 10.1210/jc.2012-2906 10.1111/cen.12793 10.1186/s12933-018-0786-9 10.2337/dc21-2113 10.1007/s12020-016-0926-5 10.1038/aps.2015.81 10.1097/gme.0b013e318271b1da 10.1111/j.1365-2265.2011.04065.x 10.1111/1440-1681.12853 10.1038/s41401-018-0080-0 10.1186/1475-2840-13-74 10.7326/0003-4819-150-9-200905050-00006 10.2337/dc20-1862 10.1136/bmjopen-2017-020683 10.1016/j.bcp.2017.02.001 10.1515/cclm-2015-0953 10.1371/journal.pone.0173799 10.1007/s00198-011-1586-1 10.1038/s41419-018-1257-7 10.1016/j.molmet.2015.01.005 10.1016/j.cell.2007.05.047 10.1016/j.jhep.2016.02.023 10.1016/j.metabol.2013.03.005 10.1038/s41467-021-25673-6 10.1002/jbmr.4041 10.1371/journal.pone.0116479 10.1152/ajpendo.00445.2015 10.1007/s40620-019-00595-1 10.1093/gerona/gly163 10.1210/jc.2008-0270 10.1210/jc.2008-1455
Cardiovascular Diabetology; Shen Y, Chen L et. al.

Jun 11th, 2022 - The association between osteocalcin and mortality has been scantly studied. We aimed to investigate the association between osteocalcin along with its trajectories and mortality based on long-term longitudinal data. We performed a retrospective cohort study of 9413 type 2 diabetic patients with at least three measurements of total serum osteocalcin within 3 years since their first inpatient dia...

Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory...
https://doi.org/10.1073/pnas.2202069119
Proceedings of the National Academy of Sciences of the Un... Americo JL, Cotter CA et. al.

Jun 10th, 2022 - Current vaccines have greatly diminished the severity of the COVID-19 pandemic, even though they do not entirely prevent infection and transmission, likely due to insufficient immunity in the upper respiratory tract. Here, we compare intramuscular and intranasal administration of a live, replication-deficient modified vaccinia virus Ankara (MVA)-based Severe Acute Respiratory Syndrome Coronavir...

Elevated Lp(a) and course of COVID-19: Is there a relationship?
https://doi.org/10.1371/journal.pone.0266814
PloS One; Pawlos A, Gorzelak-Pabiś P et. al.

Jun 9th, 2022 - Lipoprotein (a)-Lp(a) has proinflammatory, prothrombotic and proatherogenic properties and may theoretically influence the course of COVID-19. The aim of the study was to explore whether patients hospitalized due to COVID-19 with Lp(a) ≥30mg/dl may develop a worse course of the disease, increased incidence of thromboembolic complications, intubation and ICU hospitalization or death. A retrospec...

Weight changes in patients with sustained viral suppression switching tenofovir disopro...
https://doi.org/10.1002/oby.23443
Obesity (Silver Spring, Md.); Schafer JJ, Zimmerman M et. al.

Jun 9th, 2022 - Switching from tenofovir disoproxil fumarate (TDF)- to tenofovir alafenamide (TAF)-containing antiretroviral therapy may negatively influence weight, cholesterol, and atherosclerotic cardiovascular disease risk. The extent of these changes and their association with TAF remain unclear. This retrospective cohort evaluated metabolic changes in virologically suppressed patients with HIV infection ...

Grief Symptoms Promote Inflammation During Acute Stress Among Bereaved Spouses.
https://doi.org/10.1177/09567976211059502
Psychological Science; Brown RL, LeRoy AS et. al.

Jun 9th, 2022 - The death of a spouse is associated with maladaptive immune alterations; grief severity may exacerbate this link. We investigated whether high grief symptoms were associated with an amplified inflammatory response to subsequent stress among 111 recently bereaved older adults. Participants completed a standardized psychological stressor and underwent a blood draw before, 45 min after, and 2 hr a...

Interleukin-36α is elevated in diffuse systemic sclerosis and may potentiate fibrosis.
https://doi.org/10.1016/j.cyto.2022.155921
Cytokine O'Reilly S

Jun 7th, 2022 - Systemic sclerosis (SSc) is an autoimmune prototypical connective tissues disease that results in alterations in vasculature, inflammation and fibrosis of the skin. Interleukin-1 family cytokines has been implicated in the disease including IL-1. IL-36α is an IL-1 family member that is clearly implicated in psoriatic skin disease but its role in systemic sclerosis disease is not clear. The aim ...

Association of Estimated GFR Calculated Using Race-Free Equations With Kidney Failure a...
https://doi.org/10.1001/jama.2022.8801
JAMA Gutiérrez OM, Sang Y et. al.

Jun 7th, 2022 - At a given estimated glomerular filtration rate (eGFR), individuals who are Black have higher rates of mortality and kidney failure with replacement therapy (KFRT) compared with those who are non-Black. Whether the recently adopted eGFR equations without race preserve racial differences in risk of mortality and KFRT at a given eGFR is unknown. To assess whether eGFR equations with and without r...