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About 904,880 results

Immunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccines.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428655
PloS One; Wisnewski AV, Redlich CA et. al.

Sep 10th, 2021 - Reverse vaccinology is an evolving approach for improving vaccine effectiveness and minimizing adverse responses by limiting immunizations to critical epitopes. Towards this goal, we sought to identify immunogenic amino acid motifs and linear epitopes of the SARS-CoV-2 spike protein that elicit IgG in COVID-19 mRNA vaccine recipients. Paired pre/post vaccination samples from N = 20 healthy adul...

Association of coagulation disturbances with severity of COVID-19: a longitudinal study.
https://doi.org/10.1080/16078454.2021.1968648
Hematology (Amsterdam, Netherlands); Lu H, Chen M et. al.

Sep 9th, 2021 - Coagulation dysfunction is an evident factor in the clinical diagnosis and treatment of patients with coronavirus disease 2019 (COVID-19), appearing even in COVID-19 patients with normal inflammation indices. Therefore, this study aimed to analyze the characteristics of coagulation function indices in COVID-19 patients to investigate possible mechanisms through the comparison of non-severe and ...

Association between lipid biomarkers and osteoporosis: a cross-sectional study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419899
BMC Musculoskeletal Disorders; Kan B, Zhao Q et. al.

Sep 8th, 2021 - Osteoporosis and cardiovascular diseases (CVDs) are 2 major public health problems. Osteoporosis and CVDs may be linked but the association between lipid profile and osteoporosis is still controversial. The purpose of this study was to examine the associations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (T...

Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like recepto...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418785
Virology Journal; Pessoa NL, Bentes AA et. al.

Sep 7th, 2021 - Covid-19 has the respiratory tract as the main target of infection, and patients present mainly dyspnea, pneumonia, dry cough, and fever. Nevertheless, organs outside the respiratory tract had been reported in recent studies, including the gastrointestinal tract and liver. The host innate immune system recognizes pathogen-associated molecular patterns (PAMPs) through their pattern recognition r...

Neutrophil-to-lymphocyte Ratio as a Prognostic Factor for Colon Cancer in Elderly Patie...
https://doi.org/10.21873/anticanres.15256
Anticancer Research; Mazaki J, Katsumata K et. al.

Sep 4th, 2021 - This study aimed to evaluate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in elderly patients with Stage I-III colon cancer for long-term oncologic outcomes. We retrospectively reviewed 175 patients aged >75 years who underwent radical surgery for Stage I-III colon cancer between 2000 and 2015 at our institute. Overall survival (OS), cancer-specific survival (CSS), and relapse-f...

Renal Function Improves After the Discontinuation of Androgen Deprivation Therapy in Ja...
https://doi.org/10.21873/anticanres.15252
Anticancer Research; Masuda H, Fujimoto A et. al.

Sep 4th, 2021 - Androgen deprivation therapy (ADT) is one of the most effective treatments for advanced prostate cancer (PCa). However, it has been reported that the use of ADT is significantly associated with an increased risk of acute kidney injury (AKI) among patients with newly diagnosed non-metastatic PCa. We investigated changes in renal function that occurred in Japanese patients with PCa after ADT was ...

Associations Between ADC Texture Analysis and Tumor Infiltrating Lymphocytes in Brain M...
https://doi.org/10.21873/anticanres.15267
Anticancer Research; Meyer HJ, Hohn AK et. al.

Sep 4th, 2021 - Tumor infiltrating lymphocytes (TILs) are an important prognostic factor in brain metastasis (BM). This study elucidated associations between apparent diffusion coefficient (ADC) texture analysis and TIL in BM. Eleven patients with BM were retrospectively included into the study. TIL levels were analyzed with Leucocyte-common antigen staining. Clinical routine magnetic resonance imaging was use...

Clinically Applicable Serum Biomarkers Among 14 Candidates Associated With Recurrence o...
https://doi.org/10.21873/anticanres.15279
Anticancer Research; Kim CW, Ha YJ et. al.

Sep 4th, 2021 - We evaluated the predictive value of candidate serum biomarkers for recurrence in stage II and III colorectal cancer (CRC) after curative surgery. A total of 33 and 120 patients with CRC with or without recurrence at 5 years after curative surgery were included in the training set and the validation set, respectively. Possible serum biomarkers were examined for associations with CRC recurrence ...

Management of chronic myeloid leukemia presenting with isolated thrombocytosis and comp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416011
Medicine Gao L, Ren MQ et. al.

Sep 4th, 2021 - Chronic myelogenous leukemia (CML) with thrombocytosis and complex chromosomal translocation is extremely rare in clinical setting. Here, we reported the clinical and pathological characteristics of CML patients, which were characterized by thrombocytosis and complex Philadelphia chromosome translocation. Moreover, we also introduced our therapeutic schedule for this patient as well as review r...

Integration of quantitative diffusion kurtosis imaging and prostate specific antigen in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415936
Medicine Yao W, Zheng J et. al.

Sep 4th, 2021 - This study aimed to evaluate the diagnostic performance of diffusion kurtosis imaging (DKI) and prostate-specific antigen (PSA) biomarkers in differentiating prostate cancer (PCa) and benign prostatic hyperplasia (BPH).A total of 43 cases of prostate diseases verified by pathology were enrolled in the present study. These cases were assigned to the BPH group (n = 20, 68.85±10.81 years old) and ...

Analysis of Mesencephalic Astrocyte-derived Neurotrophic Factor in Multiple Myeloma.
https://doi.org/10.21873/anticanres.15235
Anticancer Research; Dernoncourt A, Sauzay C et. al.

Sep 4th, 2021 - Multiple myeloma (MM) is characterized by high production of immunoglobulins resulting in a constant source of endoplasmic reticulum (ER)-stress. Mesencephalic astrocyte-derived neurotrophic factor (MANF) was identified as a possible circulating biomarker that could help in monitoring ER-stress mediated diseases. To assess the relevance of MANF in MM, we performed in silico and in vitro analysi...

Prognostic significance of volume-based 18F-FDG PET/CT parameters and correlation with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415941
Medicine Wang D, Li Y et. al.

Sep 4th, 2021 - The aim of this study was to retrospectively analyze 18F-FDG positron emission tomography/computed tomography (18F-FDG PET/CT) metabolic variables, programmed death-ligand 1 (PD-L1) and phosphorylated signal transducer and activator of transcription 3 (p-STAT3) tumor expression, and other factors as predictors of disease-free survival (DFS) in patients with lung adenocarcinoma (LUAD) (stage IA-...

3-weekly daratumumab-lenalidomide/pomalidomide-dexamethasone is highly effective in rel...
https://doi.org/10.1080/16078454.2021.1965737
Hematology (Amsterdam, Netherlands); Chim CS, Kumar S et. al.

Sep 4th, 2021 - Myeloma relapse remains challenging. Daratumumab (dara) with immunomodulatory agents (IMiD) and dexamethasone (dex) was proven highly effective in relapsed or refractory multiple myeloma (RRMM) in randomized controlled trials. The recommended schedule of dara is weekly for eight doses, followed by 2-weekly for eight doses, and then every 4-weekly thereafter. However, the cost of daratumumab is ...

Negative effects of iodine-based contrast agent on renal function in patients with mode...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407403
BMC Nephrology; Kistner A, Tamm C et. al.

Sep 2nd, 2021 - Kidney disease and renal failure are associated with hospital deaths in patients with COVID - 19. We aimed to test if contrast enhancement affects short-term renal function in hospitalized COVID - 19 patients. Plasma creatinine (P-creatinine) was measured on the day of computed tomography (CT) and 24 h, 48 h, and 4-10 days after CT. Contrast-enhanced (n = 142) and unenhanced (n = 24) groups wer...

Performance verification of the Abbott SARS-CoV-2 test for qualitative detection of IgG...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409620
PloS One; Castro MDM, Caicedo I et. al.

Sep 2nd, 2021 - Adequate testing is critically important for control of the SARS-CoV-2 pandemic. Antibody testing is an option for case management and epidemiologic studies, with high specificity and variable sensitivity. However, characteristics of local populations may affect performance of these tests. For this reason, the National Institute of Health (INS) and regulatory agencies in Colombia require verifi...

Type I, II, and III Interferon Signatures Correspond to Coronavirus Disease 2019 Severity.
https://doi.org/10.1093/infdis/jiab288
The Journal of Infectious Diseases; Kim MH, Salloum S et. al.

Sep 2nd, 2021 - We analyzed plasma levels of interferons (IFNs) and cytokines, and expression of IFN-stimulated genes in peripheral blood mononuclear cells in patients with coronavirus disease 2019 of varying disease severity. Patients hospitalized with mild disease exhibited transient type I IFN responses, while intensive care unit patients had prolonged type I IFN responses. Type II IFN responses were compro...

A comprehensive risk score for effective risk stratification and screening of nasophary...
https://doi.org/10.1038/s41467-021-25402-z 10.5732/cjc.010.10377 10.1038/s41588-019-0436-5 10.1016/j.oraloncology.2014.02.006 10.1002/cncr.30643 10.1038/ng.601 10.1093/hmg/ddw200 10.1158/1055-9965.EPI-15-0144 10.1158/1055-9965.EPI-06-0353 10.1056/NEJMoa1701717 10.1056/NEJMoa011610 10.1093/aje/kws404 10.1093/annonc/mdz231 10.1002/ijc.26380 10.1093/jnci/djs320 10.1093/infdis/jiy542 10.1016/S0140-6736(19)30956-0 10.1002/ijc.2910290204 10.1002/1097-0142(19920101)69:1<3::AID-CNCR2820690104>3.0.CO;2-7 10.1073/pnas.1804184115 10.1016/S0009-8981(01)00665-9 10.1093/clinchem/hvaa027 10.1128/JVI.01132-18 10.18632/oncotarget.19692 10.1371/journal.ppat.1000496 10.1158/1055-9965.EPI-16-0149 10.1038/nm0602-594 10.1086/426823 10.1007/s10654-011-9567-4 10.1002/(SICI)1097-0258(19970515)16:9<965::AID-SIM509>3.0.CO;2-O
Nature Communications; Zhou X, Cao SM et. al.

Sep 2nd, 2021 - Using Epstein-Barr virus (EBV)-based markers to screen populations at high risk for nasopharyngeal carcinoma (NPC) is an attractive preventive approach. Here, we develop a comprehensive risk score (CRS) that combines risk effects of EBV and human genetics for NPC risk stratification and validate this CRS within an independent, population-based dataset. Comparing the top decile with the bottom q...

Tracheostomy for COVID-19: evolving best practice.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405347
Critical Care (London, England); Williams T, McGrath BA

Sep 1st, 2021 - This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2021. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2021 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from https://link.springer.com/bookseries/8901 .

Paediatric post-COVID-19 hyperinflammatory syndrome mimicking appendicitis: a case series.
https://doi.org/10.1308/rcsann.2021.0132
Annals of the Royal College of Surgeons of England; Coles V, Yardley I et. al.

Sep 1st, 2021 - A novel hyperinflammatory syndrome has emerged in the paediatric population: paediatric inflammatory multisystem syndrome - temporally associated with SARS-CoV-2 (PIMS-TS). Up to 50% of patients develop shock with cardiac dysfunction but presentation with acute abdominal pain is common and difficult to distinguish from appendicitis. Prospective case series of PIMS-TS patients presenting to a si...

Associations of SARS-CoV-2 serum IgG with occupation and demographics of military perso...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405017
PloS One; Zell J, Wisnewski AV et. al.

Aug 31st, 2021 - Countries across the globe have mobilized their armed forces in response to COVID-19, placing them at increased risk for viral exposure. Humoral responses to SARS-CoV-2 among military personnel serve as biomarkers of infection and provide a basis for disease surveillance and recognition of work-related risk factors. Enzyme-linked immunosorbent assays (ELISA) were used to measure SARS-CoV-2 spik...