BMC Infectious Diseases; Lyimo E, Fougeroux C et. al.
Nov 13th, 2022 - African countries stand out globally as the region seemingly least affected by the COVID-19 pandemic, caused by the virus SARS-CoV-2. Besides a younger population and potential pre-existing immunity to a SARS-CoV-2-like virus, it has been hypothesized that co-infection or recent history of Plasmodium falciparum malaria may be protective of COVID-19 severity and mortality. The number of COVID-19...
JAMA Larkin HD
Nov 2nd, 2022 - Cybersecurity Risk for Medtronic Insulin Pump.|2022|Larkin HD,|analysis,blood,drug therapy,administration & dosage,therapeutic use,administration & dosage,therapeutic use,adverse effects,
Medicine Dai C, Zhu W
Nov 2nd, 2022 - Asprosin is a newly identified adipokine with glucose-raising and appetite-enhancing effects which acts differently from the known hepatic glucose utilization pathway. This study investigated changes in serum asprosin levels in normal weight or overweight/obese liraglutide-treated patients with type 2 diabetes (T2DM). This study is a non-randomized, prospective observational study. The metaboli...
Journal of the American Heart Association; Durda P, Raffield LM et. al.
Nov 1st, 2022 - Background Monocytes/macrophages participate in cardiovascular disease. CD163 (cluster of differentiation 163) is a monocyte/macrophage receptor, and the shed sCD163 (soluble CD163) reflects monocyte/macrophage activation. We examined the association of sCD163 with incident cardiovascular disease events and performed a genome-wide association study to identify sCD163-associated variants. Method...
Hospital Pediatrics; Butala N, Berkwitt A et. al.
Oct 29th, 2022 - Contamination Frustration: Considering Value-Based Approaches to Manage Contaminated Cultures.|2022|Butala N,Berkwitt A,Osborn R,|etiology,etiology,etiology,blood,
PloS One; Ojo OA, Grant S et. al.
Oct 28th, 2022 - Annona muricata L. peel has been recognized for many ethnobotanical uses, including diabetes management. However, limited detailed scientific information about its mechanism of antidiabetic activity exists. The objective of this study was to evaluate the anti-diabetic properties of an aqueous extract of A. muricata peel (AEAMP) and its mechanism of action on alloxan-induced diabetic rats. In vi...
JAMA Walker MD, Shane E
Oct 26th, 2022 - Hypercalcemia affects approximately 1% of the worldwide population. Mild hypercalcemia, defined as total calcium of less than 12 mg/dL (<3 mmol/L) or ionized calcium of 5.6 to 8.0 mg/dL (1.4-2 mmol/L), is usually asymptomatic but may be associated with constitutional symptoms such as fatigue and constipation in approximately 20% of people. Hypercalcemia that is severe, defined as total calcium ...
JAMA Slomski A
Oct 26th, 2022 - Large Treatment Effects With Automated Insulin Delivery System.|2022|Slomski A,|analysis,blood,drug therapy,administration & dosage,therapeutic use,administration & dosage,therapeutic use,administration & dosage,therapeutic use,
JAMA Slomski A
Oct 26th, 2022 - Trial Compares Glucose-Lowering Drugs for Type 2 Diabetes.|2022|Slomski A,|analysis,blood,drug therapy,therapeutic use,therapeutic use,
BMC Endocrine Disorders; Gao F, Li C et. al.
Oct 24th, 2022 - Growth differentiation factor 15 (GDF15) was newly discovered to be a promising target of metformin. The study was aimed to investigate the relationship between GDF15 and glycemic control after metformin treatment in patients with type 2 diabetes mellitus. The study was a post-hoc analysis of AIM (the effect of Acarbose on glycemic variability in patients with type 2 diabetes mellitus using pre...
Vaccine Sapuan S, Andrews N et. al.
Oct 23rd, 2022 - An antenatal pertussis vaccination programme was introduced in 2012 in the UK in the context of a national outbreak of pertussis. It has been shown that a lower antibody response to primary immunisation can be seen for certain pertussis antigens in infants born to women who received pertussis-containing antenatal vaccines, a phenomenon known as blunting. The longer-term impact of this has not b...
Annals of Cardiac Anaesthesia; Singh KK, Kapoor A et. al.
Oct 19th, 2022 - There is a need to identify novel markers for CAD, independent of traditional CV risk factors. One of these is gamma-glutamyl transferase (GGT), a marker of increased oxidative stress. Given the high prevalence of CAD in Asian Indians, the link of GGT and CAD in them needs to be studied. To assess GGT in patients with angiographically documented CAD. Two hundred patients aged 58.1 ± 9.95 years,...
Annals of Cardiac Anaesthesia; Murugesan KB, Balakrishnan S et. al.
Oct 19th, 2022 - SGLT2i is a new class of drugs used for type 2 diabetes. SGLT2i are known to cause EuKA in the perioperative period. Euglycemic ketoacidosis (EuKA) can cause life-threatening metabolic acidosis in the perioperative setting. Though the event rate of SGLT2i associated diabetic ketoacidosis in nonoperative setting is low, incidence among peri-operative patients can be very high and remains unknown...
Behavioural Pharmacology; Li S, Zheng Y et. al.
Oct 19th, 2022 - The insufficiency of human aldehyde dehydrogenase 2 (ALDH2) has been consistently associated with high blood acetaldehyde levels and impaired locomotor function during acute alcohol intoxication. The ALDH2-associated change in peripheral glutamic acid (Glu) and gamma-aminobutyric acid (GABA) levels and its correlation with pharmacokinetics and psychomotor function remain unclear. In this study,...
International Journal of Environmental Research and Publi... Xin C, Ye M et. al.
Oct 15th, 2022 - This study aimed to compare and rank the effectiveness of aerobic exercise (AE), resistance training (RT), combined training (CT), and water exercise (WE) on vascular function and blood lipids in postmenopausal women using a network meta-analysis (NMA). We searched the PubMed, Cochrane, Embase, Web of Science, and EBSCO (SPORTDiscus) databases to identify randomized controlled trials investigat...
Annals of Palliative Medicine; Dong L, Wu G et. al.
Oct 12th, 2022 - Obstructive sleep apnea-hypopnea syndrome (OSAHS) is an independent risk factor for atherosclerosis (AS), but the mechanism is different from classical AS risk factors. Nicotinamide phosphoribosyltransferase (NAMPT) is involved in the pathophysiology of AS via multiple pathways, and its expression is closely related to hypoxia. The association of NAMPT with hypoxia and the risk of cardiovascula...
JAMA Larkin HD
Oct 12th, 2022 - Open-source Closed-Loop System Is Effective for Type 1 Diabetes.|2022|Larkin HD,|analysis,blood,drug therapy,chemically induced,administration & dosage,therapeutic use,administration & dosage,therapeutic use,
Molecular Medicine (Cambridge, Mass.); Patel MA, Knauer MJ et. al.
Oct 11th, 2022 - Long-COVID is characterized by prolonged, diffuse symptoms months after acute COVID-19. Accurate diagnosis and targeted therapies for Long-COVID are lacking. We investigated vascular transformation biomarkers in Long-COVID patients. A case-control study utilizing Long-COVID patients, one to six months (median 98.5 days) post-infection, with multiplex immunoassay measurement of sixteen blood bio...
Drug and Alcohol Dependence; Mesdom P, Colle R et. al.
Oct 10th, 2022 - Understanding mechanisms associated with depressed smokers is a relevant question given that tobacco use disorder with comorbid major depressive disorder (MDD) has worse outcomes. The beta-arrestin 1 (ARRB1) pathway is a suggested biomarker for major depressive disorder and is involved in both antidepressant mechanism of action and tobacco addiction. We aimed to assess the association between s...
Journal of Affective Disorders; Ali-Sisto T, Tolmunen T et. al.
Oct 9th, 2022 - Major depressive disorder (MDD) is a recurrent disorder that incurs a high societal burden. However, the etiology of MDD remains unclear. The functioning of several systems associated with the etiopathogenesis of MDD, such as inflammatory and stress systems, is partially modulated by the dipeptide carnosine. The study comprised 99 MDD patients and 253 non-depressed controls aged 20-71 years. Fa...