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About 925,445 results

Relationship of circulating total bilirubin, UDP-glucuronosyltransferases 1A1 and the d...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728984
BMC Gastroenterology; Ma X, Zheng X et. al.

Jan 7th, 2022 - This study aimed to investigate the correlation of circulating total bilirubin (TB) and UGT1A1 with NAFLD in Chinese Han population. 172 adults were enrolled from the Qingdao Municipal Hospital from May 2019 to October 2020. All individuals were examined with MRI-PDFF and divided into no steatosis, mild steatosis, moderate steatosis, and severe steatosis groups according to the MRI-PDFF values....

Soluble PD-L1 Concentration Is Proportional to the Expression of PD-L1 in Tissue and Is...
https://doi.org/10.1159/000518740
Oncology Shiraishi T, Toyozumi T et. al.

Jan 7th, 2022 - We determined the soluble programmed cell death-1 ligand-1 (sPD-L1) concentration in patients with esophageal squamous cell carcinoma (ESCC), and confirmed the PD-L1 expression in resected specimens. Blood samples were collected from 73 patients with histologically proven ESCC. The serum levels of sPD-L1 were measured using an enzyme-linked immunosorbent assay. The correlations between the sPD-...

Diagnostic and prognostic value of presepsin and procalcitonin in non-infectious organ ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725484
BMC Infectious Diseases; Lee S, Song J et. al.

Jan 6th, 2022 - We investigated the diagnostic and prognostic value of presepsin among patients with organ failure, including sepsis, in accordance with the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). This prospective observational study included 420 patients divided into three groups: non-infectious organ failure (n = 142), sepsis (n = 141), and septic shock (n = 137). Op...

Visual classification of three computed tomography lung patterns to predict prognosis o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721943
BMC Pulmonary Medicine; Yamada D, Ohde S et. al.

Jan 5th, 2022 - Quantitative evaluation of radiographic images has been developed and suggested for the diagnosis of coronavirus disease 2019 (COVID-19). However, there are limited opportunities to use these image-based diagnostic indices in clinical practice. Our aim in this study was to evaluate the utility of a novel visually-based classification of pulmonary findings from computed tomography (CT) images of...

IgG3 and IgM Identified as Key to SARS-CoV-2 Neutralization in Convalescent Plasma Pools.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726489
PloS One; Kober C, Manni S et. al.

Jan 5th, 2022 - Analysis of convalescent plasma derived from individuals has shown that IgG3 has the most important role in binding to SARS-CoV-2 antigens; however, this has not yet been confirmed in large studies, and the link between binding and neutralization has not been confirmed. By analyzing plasma pools consisting of 247-567 individual convalescent donors, we demonstrated the binding of IgG3 and IgM to...

Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody r...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719683
PloS One; Berendam SJ, Morgan-Asiedu PK et. al.

Jan 1st, 2022 - Different HIV vaccine regimens elicit distinct plasma antibody responses in both human and nonhuman primate models. Previous studies in human and non-human primate infants showed that adjuvants influenced the quality of plasma antibody responses induced by pediatric HIV envelope vaccine regimens. We recently reported that use of the 3M052-SE adjuvant and longer intervals between vaccinations ar...

Relationship Between Myocardial Injury During Index Hospitalization for SARS-CoV-2 Infe...
https://doi.org/10.1161/JAHA.121.022010
Journal of the American Heart Association; Weber B, Siddiqi H et. al.

Jan 1st, 2022 - Background Myocardial injury in patients with COVID-19 is associated with increased mortality during index hospitalization; however, the relationship to long-term sequelae of SARS-CoV-2 is unknown. This study assessed the relationship between myocardial injury (high-sensitivity cardiac troponin T level) during index hospitalization for COVID-19 and longer-term outcomes. Methods and Results This...

Magnolol additive improves growth performance of Linwu ducklings by modulating antioxid...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719751
PloS One; Lin Q, Liu Y et. al.

Jan 1st, 2022 - Magnolol is a bioactive polyphenolic compound commonly found in Magnolia officinalis. The aim of this study is to clarify the contribution of the magnolol additive on the growth performance of Linwu ducklings aging from 7 to 28 d, comparing to the effects of antibiotic additive (colistin sulphate). A total of 325, 7-d-old ducklings were assigned to 5 groups. Each group had 5 cages with 13 duckl...

Perioperative FOLFOX in Patients With Locally Advanced Oesogastric Adenocarcinoma.
https://doi.org/10.21873/anticanres.15472
Anticancer Research; Quesada S, Samalin E et. al.

Jan 1st, 2022 - We hypothesized that perioperative FOLFOX (5-fluorouracil, leucovorin, oxaliplatin) might be used as an alternative to standard FLOT (docetaxel, 5-fluorouracil, leucovorin, and oxaliplatin) in patients with locally advanced oesogastric adenocarcinomas (OGA), particularly those with frailties. We reviewed the charts of 61 consecutives patients treated with FOLFOX for resectable OGA to estimate o...

Thyroid Hormones and Morphological Features of Primary Breast Cancer.
https://doi.org/10.21873/anticanres.15480
Anticancer Research; Meirovitz A, Nisman B et. al.

Jan 1st, 2022 - Many experimental studies have suggested the importance of thyroid hormones in breast cancer (BC) morphogenesis. The aim of this study was to evaluate the association of thyroid hormone levels in serum of patients with primary BC with morphological presentations of the disease in pathological specimens and prognosis. We measured the serum levels of thyroid-stimulating hormone (TSH), free triiod...

High-purity Isolation for Genotyping Rare Cancer Cells from Blood Using a Microfluidic ...
https://doi.org/10.21873/anticanres.15499
Anticancer Research; Ikeda M, Koh Y et. al.

Jan 1st, 2022 - A multistep sorting method for enrichment of rare cells, such as circulating tumor cells, in the blood without cumbersome pretreatments required by most flow cytometry-based methods, which lead to high cost and decreased detection efficiency, was developed. After only hemolysis and cell staining, cancer cells are enriched by repetitive sorting (3×) based on nuclear-positive, cytokeratin-positiv...

Correlation Between Clinical Outcomes and Serum CA-125 Levels After Standard Treatment ...
https://doi.org/10.21873/anticanres.15492
Anticancer Research; Lee J, Kim JM et. al.

Jan 1st, 2022 - To analyze the relationship between clinical outcomes for epithelial ovarian cancer and serum CA-125 levels after chemotherapy in Korean women. This study included 183 patients who underwent the standard treatment regimen for epithelial ovarian cancer. They were divided into early- (I, II) and advanced-stage (III, IV) groups. Serum CA-125 level after adjuvant chemotherapy completion (post-chemo...

MUC1 and CD147 Are Promising Markers for the Detection of Circulating Tumor Cells in Sm...
https://doi.org/10.21873/anticanres.15501
Anticancer Research; Savarese-Brenner B, Heugl M et. al.

Jan 1st, 2022 - Lung cancer is the most prevalent type of cancer globally and small cell lung cancer (SCLC) accounts for only 15% of all cases but exhibits a dismal prognosis. The standard of care of SCLC has not changed for decades and novel biomarkers and novel strategies for patient's care are urgently needed. The expression of the two potential markers MUC1 and CD147 was evaluated in circulating tumor cell...

A Rare Presentation of a Non-Asian Female With Metastatic Non-small-cell Lung Cancer Ha...
https://doi.org/10.21873/anticanres.15502
Anticancer Research; Messeha SS, Nezami MA et. al.

Jan 1st, 2022 - Activating mutations of the epidermal growth factor receptor (EGFR) gene have been utilized to predict the effectiveness of EGFR tyrosine kinase inhibitor (TKI) therapy. The most common EGFR mutations are exon 19 deletion and exon 21-point mutation, which are sensitive to EGFR TKI. However, rare/complex EGFR mutations still exist, data of which are scarce and controversial. Hence, their role in...

Development of Non-alcoholic Steatohepatitis and Nodular Regenerative Hyperplasia in C5...
https://doi.org/10.21873/anticanres.15518
Anticancer Research; Inoue KI, Yamagishi H et. al.

Jan 1st, 2022 - We generated a novel disease mouse model in which a fructose-containing western diet (FD) induces development of non-alcoholic steatohepatitis (NASH). C57BL/6J mice were fed FD for 60 weeks and body weight and blood pressure were monitored. Plasma cholesterol level was measured at the end of the experiments. Histopathology of NASH was examined by hematoxylin and eosin staining, Masson-Trichrome...

From Telemedicine to the ICU-Fever and Rash in a 9-Year-Old Girl.
https://doi.org/10.1542/peds.2021-051501
Pediatrics Maffei S, De Guzman M et. al.

Jan 1st, 2022 - A 9-year-old girl presented to her primary care pediatrician via telemedicine during the initial months of the coronavirus disease 2019 pandemic because of 4 days of warmth perceived by her mother, decreased energy, and a new rash on her upper extremities. After 10 additional days of documented fever >38°C, worsening fatigue, and 1 day of nausea, vomiting, and diarrhea, she was allowed to sched...

Susceptibility of ABO blood group to COVID-19 infections: clinico-hematological, radiol...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718246
Medicine Kabrah SM, Abuzerr SS et. al.

Dec 31st, 2021 - In the wake of the COVID-19 pandemic, research indicates that the COVID-19 disease susceptibility varies among individuals depending on their ABO blood groups. Researchers globally commenced investigating potential methods to stratify cases according to prognosis depending on several clinical parameters. Since there is evidence of a link between ABO blood groups and disease susceptibility, it c...

The involvement of TGF-β1 /FAK/α-SMA pathway in the antifibrotic impact of rice bran oi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716044
PloS One; Abdel-Rahman RF, Fayed HM et. al.

Dec 30th, 2021 - The objective of the current study is to investigate the effect of rice bran oil (RBO) on hepatic fibrosis as a characteristic response to persistent liver injuries. Rats were randomly allocated into five groups: the negative control group, thioacetamide (TAA) group (thioacetamide 100 mg/kg thrice weekly for two successive weeks, ip), RBO 0.2 and 0.4 groups (RBO 0.2mL and 0.4 mL/rat/day, po) an...

Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children.
https://doi.org/10.1056/NEJMoa2108793
The New England Journal of Medicine; Turkova A, White E et. al.

Dec 30th, 2021 - Children with human immunodeficiency virus type 1 (HIV-1) infection have limited options for effective antiretroviral treatment (ART). We conducted an open-label, randomized, noninferiority trial comparing three-drug ART based on the HIV integrase inhibitor dolutegravir with standard care (non-dolutegravir-based ART) in children and adolescents starting first- or second-line ART. The primary en...

Determinants of severity among hospitalised COVID-19 patients: Hospital-based case-cont...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716035
PloS One; Zodpey SP, Negandhi H et. al.

Dec 30th, 2021 - Risk factors for the development of severe COVID-19 disease and death have been widely reported across several studies. Knowledge about the determinants of severe disease and mortality in the Indian context can guide early clinical management. We conducted a hospital-based case control study across nine sites in India to identify the determinants of severe and critical COVID-19 disease. We iden...