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New Drug Shows Promise for Levodopa-Induced Dyskinesia
https://www.parkinson.org/blog/science-news/New-Drug-Shows-Promise-for-Levodopa-Induced-Dyskinesia

People with Parkinson’s disease (PD) commonly suffer from tremors and other movement symptoms, such as slowness and stiffness, caused by the loss of dopamine-producing nerve cells in an area of the brain called the substantia nigra. The cornerstone therapy for reducing these symptoms is the drug, levodopa. Often referred to as simply L-dopa, this drug works by helping to replenish the brain’s s...

Healthcare Ready
https://healthcareready.org/

Healthcare Ready (formerly Rx Response) helps to strengthen healthcare supply chains through collaboration with public health and private sectors by addressing pressing issues before, during, and after disasters. As the convener of industry and government, we safeguard patient health by providing solutions to critical problems. And, we provide best practices for healthcare preparedness and resp...

Optimizing Supply of PPE and Other Equipment during Shortages
https://www.cdc.gov/coronavirus/2019-ncov/hcp/ppe-strategy/index.html
CDC

Personal protective equipment (PPE) is used every day by healthcare personnel (HCP) to protect themselves, patients, and others when providing care. PPE helps protect HCP from many hazards encountered in healthcare facilities. The greatly increased need for PPE caused by the COVID-19 pandemic has caused PPE shortages, posing a tremendous challenge to the U.S. healthcare system. Healthcare fa...

N95 Mask Decontamination using Standard Hospital Sterilization Technologies
https://www.medrxiv.org/content/10.1101/2020.04.05.20049346v2.full.pdf

The response to the COVID-19 epidemic is generating severe shortages of personal protective equipment around the world. In particular, the supply of N95 respirator masks has become severely depleted, with supplies having to be rationed and health care workers having to use masks for prolonged periods in many countries. We sought to test the ability of 5 different decontamination methods: au...

Face mask use in the general population and optimal resource allocation during the COVID-19 pandemic
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426871/

The ongoing novel coronavirus disease (COVID-19) pandemic has already infected millions worldwide and, with no vaccine available, interventions to mitigate transmission are urgently needed. While there is broad agreement that travel restrictions and social distancing are beneficial in limiting spread, recommendations around face mask use are inconsistent. Here, we use mathematical modeling to e...

Will COVID-19 Threaten Availability and Affordability of our Food?
https://www.usda.gov/media/blog/2020/04/16/will-covid-19-threaten-availability-and-affordability-our-food

As the COVID-19 virus continues to spread in the U.S., its impacts have reached every aspect of our lives and shook all sectors of the economy. Amid this crisis, there have been widespread worries that the disease could threaten the nation’s food production and supply systems and stoke inflation. Many began to wonder whether the food they need will continue to be available and affordable as we ...

Proper N95 Respirator Use for Respiratory Protection Preparedness
https://blogs.cdc.gov/niosh-science-blog/2020/03/16/n95-preparedness/

To aid healthcare facilities experiencing shortages of N95 respirators due to high demand across the nation, CDC developed the Strategies for Optimizing the Supply of N95 Respirators in Healthcare Settings which provides options on how to optimize supplies of disposable N95 filtering facepiece respirators (commonly called “N95 respirators”) in healthcare settings when there is limited supply.

Food Supply Chain USDA
https://www.usda.gov/coronavirus/food-supply-chain

Access to Food

Barriers against and strategies for malaria control during the COVID-19 pandemic in low...
https://doi.org/10.1186/s12936-023-04452-2
Malaria Journal; Park J, Kang S et. al.

Feb 5th, 2023 - The COVID-19 pandemic has disrupted malaria control activities globally. Notably, high levels of excess malaria morbidity and mortality in low- and middle-income countries (LMICs) were reported. Although it is crucial to systematically understand the main causes of the disruption to malaria control and synthesize strategies to prepare for future pandemics, such studies are scarce. Therefore, th...

Linalool controls the viability of Escherichia coli by regulating the synthesis and mod...
https://doi.org/10.1016/j.foodres.2022.112337
Food Research International (Ottawa, Ont.); Gao Z, Jiang S et. al.

Feb 5th, 2023 - Escherichia coli (E. coli) is a Gram-negative bacterium and some pathogenic types may cause serious diseases, foods or food environments were the primary routes for its infection. Citrus aurantium L. var. amara Engl., a variety of sour orange, were used as a kind of non-conventional edible plant in China, but its antimicrobial activity and mechanisms were not well studied. Thus, in this study, ...

Monitoring of the presence of plasticizers and effect of temperature and storage time i...
https://doi.org/10.1016/j.foodres.2022.112424
Food Research International (Ottawa, Ont.); Santana-Mayor Á, Rodríguez-Ramos R et. al.

Feb 5th, 2023 - In this work, a natural deep eutectic solvent was used for the liquid-liquid microextraction of fourteen phthalates and one adipate from bottled waters. The methodology was validated in terms of matrix effect, linearity, recovery, and limits of quantification (LOQs). Optimum extraction conditions (10 mL of water at pH 8.0 with 100 μL of thymol: menthol 2:1 (n/n) as solvent) provided satisfactor...

Design insights for upscaling spontaneous microfluidic emulsification devices based on ...
https://doi.org/10.1016/j.foodres.2022.112365
Food Research International (Ottawa, Ont.); Ten Klooster S, Berton-Carabin C et. al.

Feb 5th, 2023 - Microfluidic emulsification has the potential to produce emulsions with very controlled droplet sizes in a subtle manner. To support in unleashing this potential, we provide guidelines regarding upscaling based on the performance of Upscale Partitioned EDGE (UPE) devices, using rapeseed oil as the to-be-dispersed phase and whey proteins as the emulsifier. The UPE5x1 device (11,000 droplet forma...

Basilar artery formed by persistent primitive trigeminal artery: a case report.
https://doi.org/10.1007/s00276-023-03096-w
Surgical and Radiologic Anatomy : SRA; Tasdemir R, Yasin S et. al.

Feb 5th, 2023 - The aim of this study was to present a case of basilar artery (BA) formed by persistent primitive trigeminal artery (PPTA), which was diagnosed using digital subtraction angiography (DSA). PPTA is a common branching variation of embryological origin. The prevalence of PPTA ranges between 0.1 and 0.6%. It has been reported that PPTA typically joins the BA proximally and supplies the superior cer...

Multi-level influences on increased overdose risk behaviors during the COVID-19 pandemi...
https://doi.org/10.1186/s12954-023-00741-w
Harm Reduction Journal; Frueh L, Collins AB et. al.

Feb 5th, 2023 - The ongoing COVID-19 pandemic has disproportionately affected structurally vulnerable populations including people who use drugs (PWUD). Increased overdose risk behaviors among PWUD during the pandemic have been documented, with research underscoring the role of influencing factors such as isolation and job loss in these behaviors. Here, we use qualitative methods to examine the impact of the C...

Experiences from the Philippine grassroots: impact of strengthening primary care system...
https://doi.org/10.1186/s12913-022-08799-1
BMC Health Services Research; De Mesa RYH, Marfori JRA et. al.

Feb 5th, 2023 - Inequities in health access and outcomes persist in low- and middle-income countries. While strengthening primary care is integral in improving patient outcomes, primary care networks remain undervalued, underfunded, and underdeveloped in many LMICs such as the Philippines. This paper underscores the value of strengthening primary care system interventions in LMICs by examining their impact on ...

The life cycle study revealed distinct impact of foliar-applied nano-Cu on antioxidant ...
https://doi.org/10.1016/j.foodres.2022.112303
Food Research International (Ottawa, Ont.); Jośko I, Kusiak M et. al.

Feb 5th, 2023 - Despite that the applicability of Cu-based engineered nanoparticles (ENPs) as an antibacterial and antifungal agent for plant protection has been studied widely, little is known about their role in the improvement of crop yield and quality. Here, a full life study was performed to investigate the nutritional quality and bioactivity of barley grains under foliar application of nano-/microparticu...

Breastfeeding difficulties in the first 6 weeks postpartum among mothers with chronic c...
https://doi.org/10.1186/s12884-023-05407-w
BMC Pregnancy and Childbirth; Scime NV, Metcalfe A et. al.

Feb 4th, 2023 - Breastfeeding difficulties frequently exacerbate one another and are common reasons for curtailed breastfeeding. Women with chronic conditions are at high risk of early breastfeeding cessation, yet limited evidence exists on the breastfeeding difficulties that co-occur in these mothers. The objective of this study was to explore clusters of breastfeeding difficulties experienced up to 6 weeks p...

Determinants of depression and anxiety in homeless people: A population survey of homel...
https://doi.org/10.1177/00207640231152208
The International Journal of Social Psychiatry; Chan SM, Wong H et. al.

Feb 4th, 2023 - There are growing concerns about the homeless and mental health issues globally. This study aims to examine the mental health situation of homelessness and the determinants of anxiety and depression of them in Hong Kong. The data from the largest territory-wide study of the homeless population in 2021 was analyzed. Descriptive statistics and logistic regressions were used to investigate the ass...

From fox to fork? Toxocara contamination of spinach grown in the south of England, UK.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896772
Parasites & Vectors; Healy SR, Morgan ER et. al.

Feb 4th, 2023 - Toxocara canis and Toxocara cati are intestinal parasites of dogs, cats and foxes, with infected animals shedding eggs of the parasite in their faeces. If humans accidentally ingest embryonated Toxocara spp. eggs from the environment, severe clinical consequences, including blindness and brain damage, can occur. Previous work has demonstrated the presence of Toxocara spp. eggs on vegetable prod...

How does neurovascular unit dysfunction contribute to multiple sclerosis?
https://doi.org/10.1016/j.nbd.2023.106028
Neurobiology of Disease; Cashion JM, Young KM et. al.

Feb 4th, 2023 - Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system (CNS) and the most common non-traumatic cause of neurological disability in young adults. Multiple sclerosis clinical care has improved considerably due to the development of disease-modifying therapies that effectively modulate the peripheral immune response and reduce relapse frequency. However, current ...