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About 1,127,598 results

New Drug Shows Promise for Levodopa-Induced Dyskinesia
https://www.parkinson.org/blog/science-news/New-Drug-Shows-Promise-for-Levodopa-Induced-Dyskinesia

People with Parkinson’s disease (PD) commonly suffer from tremors and other movement symptoms, such as slowness and stiffness, caused by the loss of dopamine-producing nerve cells in an area of the brain called the substantia nigra. The cornerstone therapy for reducing these symptoms is the drug, levodopa. Often referred to as simply L-dopa, this drug works by helping to replenish the brain’s s...

Healthcare Ready
https://healthcareready.org/

Healthcare Ready (formerly Rx Response) helps to strengthen healthcare supply chains through collaboration with public health and private sectors by addressing pressing issues before, during, and after disasters. As the convener of industry and government, we safeguard patient health by providing solutions to critical problems. And, we provide best practices for healthcare preparedness and resp...

Optimizing Supply of PPE and Other Equipment during Shortages
https://www.cdc.gov/coronavirus/2019-ncov/hcp/ppe-strategy/index.html
CDC

Personal protective equipment (PPE) is used every day by healthcare personnel (HCP) to protect themselves, patients, and others when providing care. PPE helps protect HCP from many hazards encountered in healthcare facilities. The greatly increased need for PPE caused by the COVID-19 pandemic has caused PPE shortages, posing a tremendous challenge to the U.S. healthcare system. Healthcare fa...

N95 Mask Decontamination using Standard Hospital Sterilization Technologies
https://www.medrxiv.org/content/10.1101/2020.04.05.20049346v2.full.pdf

The response to the COVID-19 epidemic is generating severe shortages of personal protective equipment around the world. In particular, the supply of N95 respirator masks has become severely depleted, with supplies having to be rationed and health care workers having to use masks for prolonged periods in many countries. We sought to test the ability of 5 different decontamination methods: au...

Face mask use in the general population and optimal resource allocation during the COVID-19 pandemic
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426871/

The ongoing novel coronavirus disease (COVID-19) pandemic has already infected millions worldwide and, with no vaccine available, interventions to mitigate transmission are urgently needed. While there is broad agreement that travel restrictions and social distancing are beneficial in limiting spread, recommendations around face mask use are inconsistent. Here, we use mathematical modeling to e...

Heterologous prime-boost COVID-19 vaccination: initial reactogenicity data
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01115-6/fulltext
The Lancet; Shaw RH, .

May 12th, 2021 - There is significant international interest in heterologous prime-boost COVID-19 vaccination to mitigate against supply shocks or shortages that might otherwise reduce the speed of vaccine roll-out. Additionally, in light of changing recommendations regarding use of the ChAdOx1 nCoV-19 (ChAd) COVID-19 vaccine (Vaxzevria, AstraZeneca), several countries are now advising that individuals previous...

COVID Vaccine Distribution and Doses
https://www.washingtonpost.com/graphics/2020/health/covid-vaccine-states-distribution-doses/
The Washington Post;

Mar 21st, 2021 - As coronavirus vaccinations continue to pick up speed in the country, states are expanding the share of the population eligible to receive the growing supply of vaccines. According to new data published by the Centers for Disease Control and Prevention, a majority of U.S. adults age 65 and older have received at least one shot of a coronavirus vaccine.

Will COVID-19 Threaten Availability and Affordability of our Food?
https://www.usda.gov/media/blog/2020/04/16/will-covid-19-threaten-availability-and-affordability-our-food

As the COVID-19 virus continues to spread in the U.S., its impacts have reached every aspect of our lives and shook all sectors of the economy. Amid this crisis, there have been widespread worries that the disease could threaten the nation’s food production and supply systems and stoke inflation. Many began to wonder whether the food they need will continue to be available and affordable as we ...

Proper N95 Respirator Use for Respiratory Protection Preparedness
https://blogs.cdc.gov/niosh-science-blog/2020/03/16/n95-preparedness/

To aid healthcare facilities experiencing shortages of N95 respirators due to high demand across the nation, CDC developed the Strategies for Optimizing the Supply of N95 Respirators in Healthcare Settings which provides options on how to optimize supplies of disposable N95 filtering facepiece respirators (commonly called “N95 respirators”) in healthcare settings when there is limited supply.

Food Supply Chain USDA
https://www.usda.gov/coronavirus/food-supply-chain

Access to Food

Bioengineered Models to Study Microenvironmental Regulation of Glioblastoma Metabolism.
https://doi.org/10.1093/jnen/nlab092
Journal of Neuropathology and Experimental Neurology; Chen J, Lee H et. al.

Sep 16th, 2021 - Despite extensive research and aggressive therapies, glioblastoma (GBM) remains a central nervous system malignancy with poor prognosis. The varied histopathology of GBM suggests a landscape of differing microenvironments and clonal expansions, which may influence metabolism, driving tumor progression. Indeed, GBM metabolic plasticity in response to differing nutrient supply within these microe...

Coronavirus Disease 2019 Planning and Response: A Tale of 2 Health Workforce Estimator ...
https://doi.org/10.1097/MLR.0000000000001606
Medical Care; Chen C, Luo Q et. al.

Sep 16th, 2021 - As coronavirus disease 2019 (COVID-19) rapidly progressed throughout the United States, increased demand for health workers required health workforce data and tools to aid planning and response at local, state, and national levels. We describe the development of 2 estimator tools designed to inform health workforce planning for COVID-19. We estimated supply and demand for intensivists, critical...

Control of hippocampal pKr-2 expression reduces neurotoxic symptoms in 5XFAD mice.
https://doi.org/10.1111/bph.15681
British Journal of Pharmacology; Kim S, Moon GJ et. al.

Sep 16th, 2021 - There is a scarcity of information regarding the role of prothrombin kringle-2 (pKr-2), which can be generated by active thrombin, associated with hippocampal neurodegeneration and its mechanisms in Alzheimer's disease (AD). To assess the role of pKr-2 in association with the neurotoxic symptoms of AD, we determined pKr-2 protein levels in the postmortem hippocampal tissues of patients with AD ...

The burden of drug resistant tuberculosis in a predominantly nomadic population in Ugan...
https://doi.org/10.1186/s12879-021-06675-7 10.1371/journal.pone.0007186 10.1183/09031936.00186310 10.1055/s-0028-1085702 10.1007/s40273-015-0279-6 10.5588/ijtld.14.0679 10.2147/IDR.S126274 10.4314/ahs.v15i2.9 10.5588/ijtld.12.0823 10.1186/s12879-019-4014-3
BMC Infectious Diseases; Simbwa BN, Katamba A et. al.

Sep 16th, 2021 - Emergence of drug resistant tuberculosis (DR-TB) has aggravated the tuberculosis (TB) public health burden worldwide and especially in low income settings. We present findings from a predominantly nomadic population in Karamoja, Uganda with a high-TB burden (3500 new cases annually) and sought to determine the prevalence, patterns, factors associated with DR-TB. We used mixed methods of data co...

Projecting health labor market dynamics for a health system in transition: planning for...
https://doi.org/10.1186/s12992-021-00747-8 10.2471/BLT.07.046474
Globalization and Health; Lin TK, Bruckner TA et. al.

Sep 16th, 2021 - Health workforce planning is critical for health systems to safeguard the ability to afford, train, recruit, and retain the appropriate number and mix of health workers. This balance is especially important when macroeconomic structures are also reforming. The Kingdom of Saudi Arabia is moving toward greater diversification, privatization, and resiliency; health sectorreform is a key pillar of ...

Effects of free maternal policies on quality and cost of care and outcomes: an integrat...
https://doi.org/10.1017/S1463423621000529
Primary Health Care Research & Development; Oyugi B, Kendall S et. al.

Sep 16th, 2021 - We conducted an integrative review of the global-free maternity (FM) policies and evaluated the quality of care (QoC) and cost and cost implications to provide lessons for universal health coverage (UHC). Using integrative review methods proposed by Whittemore and Knafl (2005), we searched through EBSCO Host, ArticleFirst, Cochrane Central Registry of Controlled Trials, Emerald Insight, JSTOR, ...

Vaccine complacency and dose distribution inequities limit the benefits of seasonal inf...
https://doi.org/10.1016/j.vaccine.2021.08.097
Vaccine Palache A, Rockman S et. al.

Sep 16th, 2021 - Sustainable demand for seasonal influenza vaccines is a component of national security strategies for pandemic preparedness. However, the ongoing COVID-19 pandemic has revealed many weaknesses in the capacity of countries to design and execute sustainable vaccination programs. An influenza pandemic remains a global threat and yet there is no global monitoring system for assessing progress towar...

Radical treatment of ruptured dissecting aneurysm on the P1 segment with monotherapy us...
https://doi.org/10.1136/bcr-2021-244950
BMJ Case Reports; Sasaki N, Imamura H et. al.

Sep 16th, 2021 - The standard endovascular treatment for ruptured dissecting aneurysm is a parent artery occlusion. However, this treatment is unsuitable when the artery of the lesion gives off perforating vessels that supply blood to critical regions or when the collateral flow cannot be expected due to the sacrifice of the parent artery. Here, we present an infrequent case of ruptured dissecting aneurysm on P...

Cannabinoid and planar cell polarity signaling converges to direct placentation.
https://doi.org/10.1073/pnas.2108201118
Proceedings of the National Academy of Sciences of the Un... Kim YS, Li Y et. al.

Sep 16th, 2021 - Directed trophoblast migration toward the maternal mesometrial pole is critical for placentation and pregnancy success. Trophoblasts replace maternal arterial endothelial cells to increase blood supply to the placenta. Inferior trophoblast invasion results in pregnancy complications including preeclampsia, intrauterine growth restriction, miscarriage, and preterm delivery. The maternal chemotac...

Integrated farming with intercropping increases food production while reducing environm...
https://doi.org/10.1073/pnas.2106382118
Proceedings of the National Academy of Sciences of the Un... Chai Q, Nemecek T et. al.

Sep 15th, 2021 - Food security has been a significant issue for the livelihood of smallholder family farms in highly populated regions and countries. Industrialized farming in more developed countries has increased global food supply to meet the demand, but the excessive use of synthetic fertilizers and pesticides has negative environmental impacts. Finding sustainable ways to grow more food with a smaller envi...