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About 10,518 results

New EGFR Inhibitor Overcomes Resistance in NSCLC
https://emedicine.medscape.com/viewarticle/825157

A new EGFR inhibitor appears to overcome resistance in patients with non-small cell lung cancer (NSCLC) who have tested positive for EGFR but have stopped responding to first-line targeted therapy. At present, there is no standard treatment available for such patients, but early clinical results with the investigational drug AZD9291 (under development by AstraZeneca) suggest that it may fill th...

CT Lung Cancer Screening Would Cost Medicare $9 Billion
https://emedicine.medscape.com/viewarticle/825235

While the decision on whether Medicare should cover lung cancer screening is still up in the air, a new study warns that such screening would increase costs. Adding low-dose CT (LDCT) to the Medicare program, which covers people older than 65 year, could result in the detection of approximately 54,900 more lung cancer cases during a 5-year period, with most at an early and more treatable stage....

Treatment Ineffective in Older, Sicker Men With Early-Stage Prostate Cancer
https://emedicine.medscape.com/viewarticle/825245

Older men with early-stage prostate cancer in addition to other illnesses derive no survival benefit from aggressive surgery or radiation therapy. In fact, such treatment can be harmful and have a negative effect on quality of life, according to a retrospective study published online May 13 in Cancer. "The argument in favor of nonaggressive management in older men has been based on a common-sen...

Obesity Ups Mortality Risk in Young Breast Cancer Patients
https://emedicine.medscape.com/viewarticle/825267

Obesity increases the risk of dying from breast cancer by a third, a huge new study shows. However, the effect of obesity was only observed in premenopausal women with estrogen-receptor (ER)-positive disease. Surprisingly, obesity seemed to have little effect on outcome in postmenopausal women with ER-positive disease. In addition, in women with ER-negative disease, obesity had little effect on...

Concern for Overtreatment Using the AUA/ASTRO Guideline on Adjuvant Radiotherapy After Radical Prostatectomy
https://emedicine.medscape.com/viewarticle/825313

Abstract and Introduction Abstract Background Recently, three prospective randomized trials have shown that adjuvant radiotherapy (ART) after radical prostatectomy for the patients with pT3 and/or positive margins improves biochemical progression-free survival and local recurrence free survival. But, the optimal management of these patients after radical prostatectomy is an issue which has been...

GI Cancer's 'Paparazzi Moment'
https://emedicine.medscape.com/viewarticle/825498

Hey, everyone, this is John Marshall for Medscape. It is the end of May and that means only one thing: ASCO® is just around the corner. The ASCO (American Society of Clinical Oncology) meeting is our annual migration to Chicago where we run around from 6:00 AM until 11:00 PM, say hello to everyone, and frankly do not really learn all that much, but that is another matter altogether. This year, ...

Prostate Cancer Screening: It Ain't Dead Yet
https://emedicine.medscape.com/viewarticle/825514

Prostate Cancer Prostate cancer is the second leading cancer killer in the United States, yet 2 large randomized trials of screening for prostate cancer provided mixed, and generally unfavorable, results.[1,2] New research continues to underscore the dichotomy between the results of screening programs in Europe and the United States. However, new and highly interesting data also suggest that in...

The Effect of Testosterone Replacement Therapy on Prostate Cancer
https://emedicine.medscape.com/viewarticle/825520

Abstract and Introduction Abstract Background: Testosterone replacement therapy (TRT) is a widely accepted form of treatment worldwide for aging men with late-onset hypogonadism syndrome. Urologists have been concerned about the possibility of TRT causing prostate cancer. The aim of this study was to assess the relationship between TRT and prostate cancer. Methods: A literature review was perfo...

Counterfeit Medications and Their Negative Impacts on Health Care
https://emedicine.medscape.com/viewarticle/825608

Introduction The problem and complexity of counterfeit medications on the health of patients globally is not a new issue. In 2008, Berman[1] referenced efforts to identify and reduce the incidence and influence of counterfeit medications. Berman also pointed out that costs to society are impactful and include losses in employment, lost income and sales tax revenues, and expenses associated with...

PFOS Detected in Pease Tradeport Water System: An Alert for New Hampshire Clinicians
https://emedicine.medscape.com/viewarticle/825646

A positive test result for perfluorooctane sulfonic acid (PFOS) was found from a well that serves the Pease Tradeport and the New Hampshire (NH) Air National Guard base at Pease, according to an announcement on May 22 by the NH Department of Health and Human Services (DHHS), Division of Public Health Services (DPHS), and the NH Department of Environmental Services (DES). Because the level of PF...

Not so Fast With That TKI
https://emedicine.medscape.com/viewarticle/825716

Epidermal Growth Factor Receptor Mutations: Effect on Volume Doubling Time of Non-Small-Cell Lung Cancer Patients Nakamura R, Inage Y, Tobita R, et al J Thorac Oncol. 2014 Jan 29. [Epub ahead of print] Study Summary Nakamura and colleagues report an interesting association of EGFR mutation status with the volume doubling time (VDT), an index of the growth rate and aggressiveness of a cancer, in...

Practice-Changing Results for Metastatic Prostate Cancer
https://emedicine.medscape.com/viewarticle/826018

CHICAGO — For patients with metastatic hormone-sensitive prostate cancer, upfront chemotherapy with docetaxel, given at the same time as hormone therapy instead of later, prolongs survival. This finding, from the ECOG E3805 CHAARTED trial, is being described as "practice-changing" and "transformative". Dr. Christopher Sweeney "This is one of the biggest improvements in survival we have seen in ...

HIFU for Prostate Cancer an 'Experimental Therapy'
https://emedicine.medscape.com/viewarticle/826329

Hello. I am Dr. Gerald Chodak for Medscape. Over the past several years I have commented on the concept of focal therapy for prostate cancer treatment. I want to revisit this concept because of an article by Dr. Giannarini and colleagues[1] in the Journal of Clinical Oncology. These authors describe several problems associated with the current status of this therapy, starting with the idea of i...

Screening At-Risk Patients for Liver Cancer: Uncertain
https://emedicine.medscape.com/viewarticle/827059

Chronic hepatic disease has been recognized as a risk factor for hepatocellular carcinoma (HCC), but does that mean that all patients should be screened? It remains uncertain whether systematic screening leads to a survival advantage over clinical diagnosis, conclude the authors of a new meta-analysis, published online June 17 in the Annals of Internal Medicine. "Many guidelines recommend scree...

Caution Advised for Lung Cancer Screening in Older Adults
https://emedicine.medscape.com/viewarticle/827525

Currently, Medicare does not cover lung cancer screening with low-dose CT (LDCT) for high-risk individuals. In fact, in April, the Medicare Evidence Development & Coverage Advisory Committee (MEDCAC) voted against recommending such coverage because members were not confident that the benefits outweigh the harms in this population. It remains to be seen what the final outcome will be for Medicar...

EU Okays Bevacizumab in Ovarian Cancer, Regorafenib in GIST
https://emedicine.medscape.com/viewarticle/827527

New cancer indications have been recommended for approval by the European Union Committee for Medicinal Products for Human Use for bevacizumab (Avastin, Roche) and for regorafenib (Stivarga, Bayer). The new indication recommended for bevacizumab is use in combination with chemotherapy for the treatment of platinum-resistant recurrent ovarian cancer (based on the results of the phase 3 AURELIA t...

Advances in Mammography Are Costing Medicare a Bundle
https://emedicine.medscape.com/viewarticle/827793

The amount of money Medicare spends on screening mammography has skyrocketed because of the increased uptake of newer screening methods, but this hasn't translated into earlier cancer detection, a new study shows. In fact, the cost per person associated with breast cancer screening increased 47% from 2001 to 2009. The study was published online July 1 in the Journal of the National Cancer Insti...

'Insufficient' Progress on Noncommunicable Diseases: WHO
https://emedicine.medscape.com/viewarticle/828076

Progress on controlling noncommunicable diseases (NCDs) worldwide has been "insufficient and highly uneven" since 2011, according to a new report from the World Health Organization (WHO). Although many countries have made progress in tackling the "epidemic" of NCDs, current global mortality from NCDs remains "unacceptably high and is increasing," the report says. "Bolder measures are urgent to ...

Let the Sun Shine: Vitamin D Appears Protective in CRC
https://emedicine.medscape.com/viewarticle/828115

Plasma Vitamin D Concentration Influences Survival Outcome After a Diagnosis of Colorectal Cancer Zgaga L, Theodoratou E, Farrington SM, et al. J Clin Oncol. 2014 July 7. [Epub ahead of print] Study Summary The investigators prospectively studied 1598 patients with stage I-III colon or rectal cancers after resection. After plasma samples were obtained postoperatively, they were tested for an as...

Vasectomy Linked to Higher Risk for Lethal Prostate Cancer
https://emedicine.medscape.com/viewarticle/828130

A large cohort study has found that vasectomy is associated with a modest increase in the incidence of high-grade and lethal prostate cancer. However, vasectomy does not appear to be associated with a risk for low-grade or localized disease, according to a study published online July 7 in the Journal of Clinical Oncology. "The cumulative incidence of lethal prostate cancer during a 24-year foll...