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About 276,258 results

Can a toilet promote virus transmission? From a fluid dynamics perspective
https://aip.scitation.org/doi/10.1063/5.0013318

Currently, a novel coronavirus named “SARS-CoV-2” is spreading rapidly across the world, causing a public health crisis, economic losses, and panic. Fecal–oral transmission is a common transmission route for many viruses, including SARS-CoV-2. Blocking the path of fecal–oral transmission, which occurs commonly in toilet usage, is of fundamental importance in suppressing the spread of viruses. H...

Acute Respiratory Distress Syndrome: Diagnosis and Management
https://www.aafp.org/afp/2020/0615/p730.html
AAFP

Acute respiratory distress syndrome (ARDS) is noncardiogenic pulmonary edema that manifests as rapidly progressive dyspnea, tachypnea, and hypoxemia. Diagnostic criteria include onset within one week of a known insult or new or worsening respiratory symptoms, profound hypoxemia, bilateral pulmonary opacities on radiography, and inability to explain respiratory failure by cardiac failure or flui...

What aerosol physics tells us about airborne pathogen transmission
https://www.tandfonline.com/doi/full/10.1080/02786826.2020.1751055

While a global pandemic by SARS-CoV in 2002–2003 was averted by fast identification, effective surveillance, and quarantine, such measures cannot be easily transferred to new situations, as the case of SARS-CoV-2 demonstrates. Knowledge of the fundamental biological and physical parameters affecting transmission pathways of respiratory pathogens is thus critical for the design of effective non-...

Lilly SARS-CoV-2 Assay - Letter of Authorization
https://www.fda.gov/media/140540/download
FDA

Qualitative detection of nucleic acid from SARS-CoV-2 in nasopharyngeal swabs, oropharyngeal (throat) swabs, anterior nasal swabs, mid-turbinate nasal swabs, nasal aspirates, nasal washes and bronchoalveolar lavage (BAL) fluid from individuals suspected of COVID-19 by their healthcare provider.

Risk factors of levodopa-induced dyskinesia in Parkinson’s disease: results from the PPMI cohort
https://www.nature.com/articles/s41531-018-0069-x
NPJ Parkinson's Disease;

Levodopa-induced dyskinesias (LID) negatively impact on the quality of life of patients with Parkinson’s disease (PD). We assessed the risk factors for LID in a cohort of de-novo PD patients enrolled in the Parkinson’s Progression Markers Initiative (PPMI). This retrospective cohort study included all PD patients enrolled in the PPMI cohort. Main outcome was the incidence rate of dyskinesia, de...

Negative Nasopharyngeal and Oropharyngeal Swabs Do Not Rule Out COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180262/
Journal of Clinical Microbiology;

Coronavirus disease 19 (COVID-19) has become the Public Health Emergency of International Concern. A diagnosis is made by the detection of a novel virus or genetically similar coronavirus by molecular assay in clinical specimens (1). Nasopharyngeal and oropharyngeal (NP/OP) samples are commonly used as a screening tool. Here, we reported a case of COVID-19 pneumonia diagnosed from bronchoalveol...

Clinical and radiological features of severe acute respiratory syndrome coronavirus 2 m...
https://doi.org/10.1111/ene.14687
European Journal of Neurology; de Freitas GR, Figueiredo MR et. al.

Sep 16th, 2021 - This case illustrates for the first time the clinical and radiological evolution of SARS-CoV-2 meningo-encephalitis. A case of a SARS-CoV-2 meningo-encephalitis is reported. A 65-year-old man with COVID-19 presenting with meningo-encephalitis without respiratory involvement is described. He had fever, diarrhea and vomiting, followed by diplopia, urinary retention and sleepiness. Examination dis...

High diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspirati...
https://doi.org/10.1186/s12879-021-06413-z 10.17886/rkipubl-2015-005 10.1056/NEJMra1008049 10.1016/S2352-4642(19)30337-2 10.1371/journal.pmed.1003076 10.1016/S1473-3099(16)30216-X 10.1016/j.athoracsur.2013.07.005 10.1164/ajrccm.183.1.136 10.1136/thoraxjnl-2011-200063 10.4103/JOC.JOC_150_18 10.1002/ppul.23415 10.1007/s12098-014-1665-3 10.1002/ppul.22887 10.1002/ppul.24596 10.1016/S2213-2600(15)00095-8 10.1007/s00112-015-0003-9 10.1378/chest.1435S1 10.1002/ppul.20979 10.1002/ppul.24313 10.1002/ppul.21303 10.1097/LBR.0000000000000169 10.7863/ultra.15.14.06017 10.1542/peds.2019-0262 10.1002/ppul.22970 10.1378/chest.12-0350 10.1002/ppul.24472
BMC Infectious Diseases; Geweniger A, Janda A et. al.

Sep 16th, 2021 - The microbiological diagnosis of pulmonary tuberculosis (Tb) in a pediatric population is hampered by both low pathogen burden and noncompliance with sputum sampling. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been found useful for the evaluation of mediastinal pathologies in adults, for children, sparse data are available. Here, we have evaluated ...

UHPLC-MS-MS analysis of oxylipins metabolomics components of follicular fluid in infert...
https://doi.org/10.1186/s12958-021-00825-x 10.1007/s10815-014-0186-3 10.5152/jtgga.2012.28 10.1093/humrep/dew027 10.1016/j.fertnstert.2017.09.011 10.1155/2016/3164734 10.1016/j.yjmcc.2014.03.007 10.18388/abp.2003_3689 10.1016/B978-0-12-800095-3.00004-3 10.1007/s10815-013-9974-4 10.1186/1477-7827-10-49 10.1016/j.chemosphere.2019.02.092 10.1530/REP-13-0111 10.1016/j.theriogenology.2019.03.009 10.1038/nature07762 10.1210/jc.2013-3839 10.1016/j.fertnstert.2012.06.025 10.1016/j.ajog.2017.02.027 10.3389/fendo.2020.00487 10.1097/MD.0000000000021979 10.3945/an.114.007732 10.1007/s10555-020-09904-8 10.1038/aps.2018.24 10.1016/j.plefa.2020.102157 10.2174/138920111795909087 10.3945/an.116.012187 10.1371/journal.pone.0087726 10.1095/biolreprod.107.060558 10.1016/j.jare.2018.03.005 10.1371/journal.pone.0119087 10.1530/REP-06-0220 10.1016/j.vph.2016.09.005 10.1111/j.1439-0531.2011.01762.x 10.1111/j.1439-0531.2008.01264.x 10.3390/nu8010010 10.3390/ani9060374 10.1002/mrd.23343 10.1146/annurev.pharmtox.45.120403.100045 10.1016/j.prostaglandins.2016.04.004 10.1016/j.freeradbiomed.2008.10.028 10.1016/j.prostaglandins.2012.12.002 10.1152/ajpregu.00125.2018 10.1016/S0303-7207(97)00128-7 10.1093/humrep/dep424 10.1016/S0092-8674(00)80402-X 10.1074/jbc.M608202200 10.1016/j.rbmo.2013.11.005 10.1186/s12958-020-00598-9 10.1210/er.2018-00075 10.3389/fendo.2019.00467 10.1016/j.theriogenology.2021.05.008 10.1210/en.2016-1252 10.1016/0092-8674(95)90193-0 10.1095/biolreprod.102.012831 10.1158/1541-7786.MCR-10-0002 10.4161/chan.4.5.13226 10.1016/j.cbi.2006.08.005
Reproductive Biology and Endocrinology : RB&E; Liang C, Zhang X et. al.

Sep 16th, 2021 - Diminished ovarian reserve (DOR) refers to a decrease in the number and quality of oocytes in the ovary, which results in a lack of sex hormones and a decline of fertility in women. DOR can potentially progress to premature ovarian failure (POF), which has a negative impact on women's quality of life and is a major cause of female infertility. Oxidative stress is a major contributor to fertilit...

Physiologic, metabolic, and toxicologic profile of 1,3-butanediol.
https://doi.org/10.1124/jpet.121.000796
The Journal of Pharmacology and Experimental Therapeutics; McCarthy CG, Waigi EW et. al.

Sep 16th, 2021 - Ketone bodies are essential energy substrates in the absence of exogenous nutrients, and more recently, they have been suggested to prevent disease and improve longevity. β-hydroxybutyrate (βHB) is the most abundant ketone body. The secondary alcohol, 1,3-butanediol (1,3-BD), is commonly administered to raise βHB bioavailability in vivo and in the absence of nutrient deprivation. However, the c...

Ocular Surface Microbiota in Diabetic Patients With Dry Eye Disease.
https://doi.org/10.1167/iovs.62.12.13
Investigative Ophthalmology & Visual Science; Zhang Z, Zou X et. al.

Sep 16th, 2021 - To investigate the ocular surface (OS) commensal bacteria profiles of patients with diabetes mellitus (DM) and dry eye disease (DED). In the present study, subjects were assigned to four groups: 37 to the diabetic mellitus with dry eye disease (DM with DED) group, 22 to the diabetes mellitus (DM)-only group, 34 to the dry eye disease (DED)-only group, and 22 to the control group. Tear fluid was...

Uterine kisspeptin receptor critically regulates epithelial estrogen receptor Α transcr...
https://doi.org/10.1093/molehr/gaab060
Molecular Human Reproduction; Schaefer J, Vilos AG et. al.

Sep 16th, 2021 - Embryo implantation failure is a major cause of infertility in women of reproductive age and a better understanding of uterine factors that regulate implantation is required for developing effective treatments for female infertility. This study investigated the role of the uterine kisspeptin receptor (KISS1R) in the molecular regulation of implantation in a mouse model. To conduct this study, a...

Conductive hearing loss in the Hyp mouse model of X-linked hypophosphatemia is accompan...
https://doi.org/10.1002/jbmr.4443
Journal of Bone and Mineral Research : the Official Journ... Delsmann MM, Seist R et. al.

Sep 16th, 2021 - X-linked hypophosphatemia (XLH) is a hereditary musculoskeletal disorder caused by loss-of-function mutations in the PHEX gene. In XLH, increased circulating fibroblast growth factor 23 (FGF23) levels cause renal phosphate wasting and low concentrations of 1,25-dihydroxyvitamin D, leading to an early clinical manifestation of rickets. Importantly, hearing loss is commonly observed in XLH patien...

Neglected Parasitic Infections: What Family Physicians Need to Know-A CDC Update.
https://www.ncbi.nlm.nih.gov/pubmed/34523888
American Family Physician; Cantey PT, Montgomery SP et. al.

Sep 16th, 2021 - Chagas disease, cysticercosis, and toxoplasmosis affect millions of people in the United States and are considered neglected parasitic diseases. Few resources are devoted to their surveillance, prevention, and treatment. Chagas disease, transmitted by kissing bugs, primarily affects people who have lived in Mexico, Central America, and South America, and it can cause heart disease and death if ...

Changes in histaminergic system in neuropsychiatric disorders and the potential treatme...
https://doi.org/10.2174/1570159X19666210909144930
Current Neuropharmacology; Shan L, Swaab DF

Sep 16th, 2021 - In contrast to that of other monoamine neurotransmitters, the association of the histaminergic system with neuropsychiatric disorders is not well documented. In the last two decades, several clinical studies involved in the development of drugs targeting the histaminergic system have been reported. These include the H3R-antagonist/inverse agonist, pitolisant, used for the treatment of excessive...

Respiratory Mechanics and Association With Inflammation in COVID-19-Related ARDS.
https://doi.org/10.4187/respcare.09156
Respiratory Care; Bhatt A, Deshwal H et. al.

Sep 16th, 2021 - The novel coronavirus-associated ARDS (COVID-19 ARDS) often requires invasive mechanical ventilation. A spectrum of atypical ARDS with different phenotypes (high vs low static compliance) has been hypothesized in COVID-19. We conducted a retrospective analysis to identify respiratory mechanics in COVID-19 ARDS. Berlin definition was used to categorize severity of ARDS. Correlational analysis us...

Liquid biopsy of cerebrospinal fluid for MYD88 L265P mutation is useful for diagnosis o...
https://doi.org/10.1111/cas.15133
Cancer Science; Yamagishi Y, Sasaki N et. al.

Sep 16th, 2021 - The current standard of diagnosing CNS lymphoma is stereotactic biopsy, however the procedure has a risk of surgical complication. Liquid biopsy of the CSF is a less invasive, non-surgical method that can be used for diagnosing CNS lymphoma. In this study, we established a clinically applicable protocol for determining mutations in MYD88 in the CSF of patients with CNS lymphoma. CSF was collect...

ADAM10 Partially Protects Mice against Influenza Pneumonia by Suppressing Specific Myel...
https://doi.org/10.1152/ajplung.00619.2020
American Journal of Physiology. Lung Cellular and Molecul... Okamori S, Ishii M et. al.

Sep 16th, 2021 - The influenza virus infection poses a serious health threat worldwide. Myeloid cells play pivotal roles in regulating innate and adaptive immune defense. A disintegrin and metalloproteinase (ADAM) family of proteins contribute to various immune responses; however, the role of ADAM10 in influenza virus infection remains largely unknown. Herein, we investigated its role, focusing on myeloid cells...

Correlation of fetal ventricular size and need for postnatal cerebrospinal fluid divers...
https://doi.org/10.1002/uog.24767
Ultrasound in Obstetrics & Gynecology : the Official Jour... Agrawal S, Al-Refai A et. al.

Sep 16th, 2021 - Open spina bifida is a common cause of hydrocephalus in the postnatal period. However, in-utero closure of the fetal spinal defect has decreased the need for cerebrospinal fluid (CSF) diversion surgery postnatally. Good prenatal predictors of the need for postnatal CSF diversion surgery are currently lacking. In this study, we aim to assess the correlation of fetal ventriculomegaly, the evoluti...

Mid- and Long-Term Follow-Up Efficacy Analysis of 3D-Printed Interbody Fusion Cages for...
https://doi.org/10.1111/os.13005
Orthopaedic Surgery; Jin YZ, Zhao B et. al.

Sep 16th, 2021 - To evaluate the safety and stability of 3D-printed interbody fusion cages (3D-printed cages) in anterior cervical discectomy and fusion (ACDF) by investigating the mid- and long-term follow-up outcomes. In this prospective study, the clinical data of 30 patients with CSM admitted to the Second Hospital of Shanxi Medical University from May 2012 to May 2014 were analyzed. The cohort comprised 18...