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About 297,265 results

What aerosol physics tells us about airborne pathogen transmission
https://www.tandfonline.com/doi/full/10.1080/02786826.2020.1751055

While a global pandemic by SARS-CoV in 2002–2003 was averted by fast identification, effective surveillance, and quarantine, such measures cannot be easily transferred to new situations, as the case of SARS-CoV-2 demonstrates. Knowledge of the fundamental biological and physical parameters affecting transmission pathways of respiratory pathogens is thus critical for the design of effective non-...

Lilly SARS-CoV-2 Assay - Letter of Authorization
https://www.fda.gov/media/140540/download
FDA

Qualitative detection of nucleic acid from SARS-CoV-2 in nasopharyngeal swabs, oropharyngeal (throat) swabs, anterior nasal swabs, mid-turbinate nasal swabs, nasal aspirates, nasal washes and bronchoalveolar lavage (BAL) fluid from individuals suspected of COVID-19 by their healthcare provider.

Risk factors of levodopa-induced dyskinesia in Parkinson’s disease: results from the PPMI cohort
https://www.nature.com/articles/s41531-018-0069-x
NPJ Parkinson's Disease;

Levodopa-induced dyskinesias (LID) negatively impact on the quality of life of patients with Parkinson’s disease (PD). We assessed the risk factors for LID in a cohort of de-novo PD patients enrolled in the Parkinson’s Progression Markers Initiative (PPMI). This retrospective cohort study included all PD patients enrolled in the PPMI cohort. Main outcome was the incidence rate of dyskinesia, de...

Can a toilet promote virus transmission? From a fluid dynamics perspective
https://aip.scitation.org/doi/10.1063/5.0013318

Currently, a novel coronavirus named “SARS-CoV-2” is spreading rapidly across the world, causing a public health crisis, economic losses, and panic. Fecal–oral transmission is a common transmission route for many viruses, including SARS-CoV-2. Blocking the path of fecal–oral transmission, which occurs commonly in toilet usage, is of fundamental importance in suppressing the spread of viruses. H...

Acute Respiratory Distress Syndrome: Diagnosis and Management
https://www.aafp.org/afp/2020/0615/p730.html
AAFP

Acute respiratory distress syndrome (ARDS) is noncardiogenic pulmonary edema that manifests as rapidly progressive dyspnea, tachypnea, and hypoxemia. Diagnostic criteria include onset within one week of a known insult or new or worsening respiratory symptoms, profound hypoxemia, bilateral pulmonary opacities on radiography, and inability to explain respiratory failure by cardiac failure or flui...

Negative Nasopharyngeal and Oropharyngeal Swabs Do Not Rule Out COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180262/
Journal of Clinical Microbiology;

Coronavirus disease 19 (COVID-19) has become the Public Health Emergency of International Concern. A diagnosis is made by the detection of a novel virus or genetically similar coronavirus by molecular assay in clinical specimens (1). Nasopharyngeal and oropharyngeal (NP/OP) samples are commonly used as a screening tool. Here, we reported a case of COVID-19 pneumonia diagnosed from bronchoalveol...

Molecular diagnosis of adult patients with clinically unexplained hypokalemia without h...
https://doi.org/10.1111/cge.14168
Clinical Genetics; Zhang X, Pan X et. al.

May 24th, 2022 - Hypokalemia is a common disorder in clinical settings; however, nonmolecular diagnostic testing cannot explain some causes of hypokalemia. To determine the etiology of clinically unexplained hypokalemia without hypertension (CUHypoNH) and to obtain a diagnostic yield of monogenic hypokalemia without hypertension in adults (MHNHA), we enrolled 82 patients with CUHypoNH for whole-exome sequencing...

The Correlations of Plasma Liver-Type Fatty Acid-Binding Protein with Amyloid-β and Tau...
https://doi.org/10.3233/JAD-220126
Journal of Alzheimer's Disease : JAD; Cheng Y, Jian JM et. al.

May 24th, 2022 - The dysregulation of lipid metabolism plays an important role in the pathogenesis of Alzheimer's disease (AD). Liver-type fatty acid-binding protein (L-FABP, also known as FABP1) is critical for fatty acid transport and may be involved in AD. To investigate whether the FABP1 level is altered in patients with AD, and its associations with levels of amyloid-β (Aβ) and tau in the plasma and cerebr...

Fluctuations in food and fluid intake during a 24-h World Championship: analysis of the...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116402
Journal of the International Society of Sports Nutrition; Charlot K, Lavoué C et. al.

May 24th, 2022 - A food and fluid intake program is essential for ultraendurance athletes to maximize performance and avoid possible gastrointestinal symptoms (GIS). However, the ability to follow such a program during a race has been under-assessed. We thus investigated the fluctuations of food and fluid intake during the 24-h run World Championship of 12 elite athletes (6 men and 6 women; age: 46 ± 7 years, h...

Hypomagnesemia and Hypokalemia: Considerations for Cancer Care.
https://doi.org/10.1188/22.CJON.313-317
Clinical Journal of Oncology Nursing; Kuruppath J, Patel P

May 24th, 2022 - Electrolyte imbalances can frequently occur among patients with cancer. Hypomagnesemia and hypokalemia are side effects of certain chemotherapies, including cisplatin, cetuximab, eribulin, and ifosfamide. When patients concurrently receive chemotherapy and take medications that cause hypomagnesemia or hypokalemia, electrolyte imbalances are amplified. Provider and patient education are vital to...

Applications of the Guarded-Needle External Drainage Technique in Vitreoretinal Surgery.
https://doi.org/10.1097/IAE.0000000000003483
Retina (Philadelphia, Pa.); Felfeli T, Grewal PS et. al.

May 24th, 2022 - To describe the surgical technique utilizing the guarded-needle external drainage for a wide variety of applications in vitreoretinal surgery. A step-by-step procedure and a surgical video using the guarded-needle external drainage technique are presented. Additionally, a series of representative cases with wide-ranging diagnoses who underwent the technique are reviewed. The guarded-needle usin...

The E/e' Ratio: As "Critical" As the Left Ventricular Ejection Fraction?
https://doi.org/10.1097/HPC.0000000000000288
Critical Pathways in Cardiology; Krantz MJ, Rudo T et. al.

May 24th, 2022 - Ascertainment of the left ventricular ejection fraction is the primary reason for ordering echocardiography in the acute care setting; however, this parameter does not provide information regarding a patient's volume status. As such, it cannot be reliably used to inform decisions regarding intravenous fluid resuscitation or diuresis, particularly in undifferentiated dyspnea and hypotension. Thi...

Transfer of Invitro CD4 + T Cells with Hypomethylation of Perforin Promoter into Rats' ...
https://doi.org/10.1080/15412555.2022.2072720
COPD Liu JJ, Liu L et. al.

May 24th, 2022 - Our previous study suggested that hypomethylation of perforin promoter of CD4 + T cells might be involved in the pathogenesis of autoimmune emphysema of rats. Whether transfer of this kind of cells hypomethylated in vitro into naive immunocompetent rats also results in emphysema is unknown yet. To test the hypothesis above, thirty Sprague Dawley (SD) rats were randomly divided into three groups...

Case 302: Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhance...
https://doi.org/10.1148/radiol.204423
Radiology Vattoth S, Aker L et. al.

May 24th, 2022 - Part one of this case appeared 4 months previously and may contain larger images. A 21-year-old immunocompetent man who was a long-term resident of Qatar presented to the emergency department with recurrent episodes of unprovoked generalized tonic-clonic seizures lasting 2-3 minutes that spontaneously resolved and were associated with postictal confusion. The patient also had progressive mild d...

The impact of clinical association between gout and dementia: a nationwide population-b...
https://doi.org/10.1002/acr.24959
Arthritis Care & Research; Kim JH, Yim DH et. al.

May 24th, 2022 - Hyperuricemia might have neuroprotective or neurodegenerative effects on dementia via oxidative stress or inflammatory response regulation. Few studies have explored the association of hyperuricemia or gout with dementia. This retrospective cohort study aimed to investigate the association between gout and dementia in Korea. Altogether, 5,052 gout patients and 25,260 age- and sex-matched contro...

Liquid biopsy in Retinoblastoma: A review.
https://doi.org/10.1080/08820538.2022.2078165
Seminars in Ophthalmology; Ghose N, Kaliki S

May 24th, 2022 - Retinoblastoma (RB) is the most common intraocular malignancy in children. The diagnosis of RB is mainly based on clinical features and imaging characteristics. Prognosis is based on stage of disease and response to treatment. In salvaged globes, direct tumor biopsy for genetic analysis and prognostication is an absolute contraindication at this point of time for the fear of extraocular tumor s...

Fluid and electrolyte management in preterm infants with patent ductus arteriosus.
https://doi.org/10.3233/NPM-210943
Journal of Neonatal-perinatal Medicine; Lalitha R, Bitar E et. al.

May 24th, 2022 - Optimal fluid management of preterm babies with suspected or confirmed diagnosis of patent ductus arteriosus (PDA) is frequently challenging for neonatal care physician because of paucity of clinical trials. There is wide variation in practice across neonatal units, resulting in significant impact on outcomes in Extremely Low Birth Weight (ELBW) babies with hemodynamically significant PDA. A de...

Silibinin Schiff Base Derivatives Counteract CCl4-Induced Acute Liver Injury by Enhanci...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122151
Drug Design, Development and Therapy; Xu R, Qiu S et. al.

May 24th, 2022 - Silibinin (Sil), a flavonoid lignan-like natural compound derived from milk thistle seeds, has been used to treat hepatic diseases, including early-phase hepatocirrhosis and fatty liver, for many years. However, its poor water solubility limits its gastrointestinal absorption and bioavailability. It clinical use has been limited due to its slow onset of action. Faced with this problem, research...

Nasoseptal flap and rigid reconstruction in endoscopic endonasal skull base surgeries: ...
https://doi.org/10.1177/01455613221099483
Ear, Nose, & Throat Journal; Alshareef M, Alroqi A et. al.

May 24th, 2022 - Recently, endoscopic endonasal approaches (EEA) have been used for skull base defect reconstruction surgeries. The nasoseptal flap (NSF), a vascular pedicled flap, was introduced to decrease postoperative cerebrospinal fluid (CSF) leakage. This study aimed to outline the authors' institutional experience using NSF and rigid implants in anterior skull base defect reconstruction surgeries followi...

High-Dosage Fosfomycin Results in Adequate Plasma and Target-Site Exposure in Morbidly ...
https://doi.org/10.1128/aac.02302-21
Antimicrobial Agents and Chemotherapy; Busse D, Simon P et. al.

May 24th, 2022 - The objectives of this study were the identification in (morbidly) obese and nonobese patients of (i) the most appropriate body size descriptor for fosfomycin dose adjustments and (ii) adequacy of the currently employed dosing regimens. Plasma and target site (interstitial fluid of subcutaneous adipose tissue) concentrations after fosfomycin administration (8 g) to 30 surgery patients (15 obese...