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About 307,265 results

What aerosol physics tells us about airborne pathogen transmission
https://www.tandfonline.com/doi/full/10.1080/02786826.2020.1751055

While a global pandemic by SARS-CoV in 2002–2003 was averted by fast identification, effective surveillance, and quarantine, such measures cannot be easily transferred to new situations, as the case of SARS-CoV-2 demonstrates. Knowledge of the fundamental biological and physical parameters affecting transmission pathways of respiratory pathogens is thus critical for the design of effective non-...

Lilly SARS-CoV-2 Assay - Letter of Authorization
https://www.fda.gov/media/140540/download
FDA

Qualitative detection of nucleic acid from SARS-CoV-2 in nasopharyngeal swabs, oropharyngeal (throat) swabs, anterior nasal swabs, mid-turbinate nasal swabs, nasal aspirates, nasal washes and bronchoalveolar lavage (BAL) fluid from individuals suspected of COVID-19 by their healthcare provider.

Risk factors of levodopa-induced dyskinesia in Parkinson’s disease: results from the PPMI cohort
https://www.nature.com/articles/s41531-018-0069-x
NPJ Parkinson's Disease;

Levodopa-induced dyskinesias (LID) negatively impact on the quality of life of patients with Parkinson’s disease (PD). We assessed the risk factors for LID in a cohort of de-novo PD patients enrolled in the Parkinson’s Progression Markers Initiative (PPMI). This retrospective cohort study included all PD patients enrolled in the PPMI cohort. Main outcome was the incidence rate of dyskinesia, de...

Can a toilet promote virus transmission? From a fluid dynamics perspective
https://aip.scitation.org/doi/10.1063/5.0013318

Currently, a novel coronavirus named “SARS-CoV-2” is spreading rapidly across the world, causing a public health crisis, economic losses, and panic. Fecal–oral transmission is a common transmission route for many viruses, including SARS-CoV-2. Blocking the path of fecal–oral transmission, which occurs commonly in toilet usage, is of fundamental importance in suppressing the spread of viruses. H...

Acute Respiratory Distress Syndrome: Diagnosis and Management
https://www.aafp.org/afp/2020/0615/p730.html
AAFP

Acute respiratory distress syndrome (ARDS) is noncardiogenic pulmonary edema that manifests as rapidly progressive dyspnea, tachypnea, and hypoxemia. Diagnostic criteria include onset within one week of a known insult or new or worsening respiratory symptoms, profound hypoxemia, bilateral pulmonary opacities on radiography, and inability to explain respiratory failure by cardiac failure or flui...

Emergency medical services facing critical dextrose shortage
https://www.cidrap.umn.edu/news-perspective/2022/08/emergency-medical-services-facing-critical-dextrose-shortage
CIDRAP - Center for Infectious Disease Research and Policy; Van Beusekom M.

Aug 4th, 2022 - Amid shortages going back months to over a year of dextrose syringes and intravenous fluid bags to treat a wide variety of emergency conditions, US emergency medical services (EMS) are scrambling to adapt treatment protocols and conduct trainings on how to use them.

Negative Nasopharyngeal and Oropharyngeal Swabs Do Not Rule Out COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180262/
Journal of Clinical Microbiology;

Coronavirus disease 19 (COVID-19) has become the Public Health Emergency of International Concern. A diagnosis is made by the detection of a novel virus or genetically similar coronavirus by molecular assay in clinical specimens (1). Nasopharyngeal and oropharyngeal (NP/OP) samples are commonly used as a screening tool. Here, we reported a case of COVID-19 pneumonia diagnosed from bronchoalveol...

Cryptococcus neoformans Presenting as a Lung Mass in an Immunocompromised Patient.
https://doi.org/10.12659/AJCR.936968
The American Journal of Case Reports; Qurashi S, Saleem T et. al.

Oct 3rd, 2022 - BACKGROUND Pulmonary cryptococcosis is an uncommon infection mainly affecting immunocompromised individuals. Presentation of cryptococcal disease ranges from asymptomatic pulmonary colonization to severe pneumonia. It can progress to acute respiratory failure and life-threatening meningoencephalitis. CASE REPORT A 55-year-old woman with a history of a kidney transplant, on immunosuppressive the...

INSULIN RESISTANCE RELATES TO DKA SEVERITY AND AFFECTS INSULIN REQUIREMENT IN CHILDREN ...
https://doi.org/10.1111/pedi.13424
Pediatric Diabetes; Mastromauro C, Polidori N et. al.

Oct 3rd, 2022 - Fluid and insulin treatments are the cornerstones of DKA management and indications on dosages are available. However, according to possible confounding factors, relevant data are still required to explain the different insulin dosages adopted at diabetes onset, particularly based upon insulin sensitivity. We aimed to explore whether DKA severity is related to different insulin sensitivity stat...

Stereoelectroencephalography before 2 years of age.
https://doi.org/10.3171/2022.7.FOCUS22336
Neurosurgical Focus; Rahman RK, Tomlinson SB et. al.

Oct 3rd, 2022 - Stereoelectroencephalography (SEEG) is a widely used technique for localizing seizure onset zones prior to resection. However, its use has traditionally been avoided in children under 2 years of age because of concerns regarding pin fixation in the immature skull, intraoperative and postoperative electrode bolt security, and stereotactic registration accuracy. In this retrospective study, the a...

Clinical analysis of the serum muscle enzyme spectrum of patients with newly diagnosed ...
https://doi.org/10.1097/MD.0000000000030834
Medicine Gao H, Xiang Q et. al.

Oct 2nd, 2022 - We investigated the factors associated with serum muscle enzyme elevation in patients with Sheehan's syndrome. A total of 48 patients who were newly diagnosed with Sheehan's syndrome were included and divided into 3 groups: Group 1, creatine kinase (CK) ≥ 1000 U/L; Group 2, 140 < CK < 1000 U/L; and Group 3, CK ≤ 140 U/L. Differences in serum muscle enzymes, serum electrolytes, blood glucose and...

Study on the mechanism of warming yang and reducing turbidity decoction in the treatmen...
https://doi.org/10.1097/MD.0000000000030728
Medicine Cui QQ, Li XM et. al.

Oct 2nd, 2022 - This study aimed to investigate the mechanism of warming yang and reducing turbidity decoction in the treatment of diabetic kidney disease (DKD) by network pharmacology. The active components and corresponding targets of warming yang and reducing turbidity decoction were screened through the Traditional Chinese Medicine Systems Pharmacology database, DKD-related targets were obtained from Genec...

Genomic analysis, immunomodulation and deep phenotyping of patients with nodding syndrome.
https://doi.org/10.1093/brain/awac357
Brain : a Journal of Neurology; Soldatos A, Nutman TB et. al.

Oct 2nd, 2022 - The etiology of Nodding Syndrome remains unclear, and comprehensive genotyping and phenotyping data from patients remain sparse. Our objectives were to characterize the phenotype of patients with Nodding Syndrome, investigate potential contributors to disease etiology, and evaluate response to immunotherapy. This cohort study investigated members of a single-family unit from Lamwo District, Uga...

Hippocampal synaptic dysfunction and spatial memory impairment in omeprazole-treated rats.
https://doi.org/10.1007/s11011-022-01088-0
Metabolic Brain Disease; Thongon N, Chamniansawat S

Oct 2nd, 2022 - Although the association of prolonged use of proton pump inhibitors, such as omeprazole, with memory impairment has been reported more than two decades ago, its underlying molecular mechanism is yet to be determined. Thus, in this study, we aimed to determine the mechanisms underlying the effect of prolonged omeprazole treatment on hippocampal synaptic function and spatial memory in male rats. ...

U-Shaped Relationship of Sodium-to-chloride Ratio on admission and Mortality in Elderly...
https://doi.org/10.1016/j.cpcardiol.2022.101419
Current Problems in Cardiology; Fu Z, Zhang X et. al.

Oct 2nd, 2022 - Serum sodium and chloride have clinical significance in the prognosis of heart failure. Little is known regarding the prognostic value of sodium-to-chloride (Na/Cl) ratio in patients with heart failure. This study sought to investigate the association between Na/Cl ratio on admission and mortality risk of elderly patients with acute heart failure in a retrospective cohort. We included 1819 pati...

Study of damage control strategy for non-traumatic diseases: a single-center observatio...
https://doi.org/10.1186/s40001-022-00823-8
European Journal of Medical Research; Nakamura F, Yui R et. al.

Oct 2nd, 2022 - Damage control strategy (DCS) has been introduced not only for trauma but also for acute abdomen, but its indications and usefulness have not been clarified. We examined clinical characteristics of patients who underwent DCS and compared clinical characteristics and results with and without DCS in patients with septic shock. We targeted a series of endogenous abdominal diseases in Kansai Medica...

A prediction model for 30-day mortality of sepsis patients based on intravenous fluids ...
https://doi.org/10.1097/MD.0000000000030578
Medicine Wang Y, Feng S

Oct 2nd, 2022 - To establish a prediction model for the 30-day mortality in sepsis patients. The data of 1185 sepsis patients were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) and all participants were randomly divided into the training set (n = 829) and the testing set (n = 356). The model was established in the training set and verified in the testing set. After standardizat...

A case report of possible concurrent vasculitis in vertebral bodies and partial transve...
https://doi.org/10.1097/MD.0000000000030814
Medicine Chen Y, Li Y et. al.

Oct 2nd, 2022 - Cases with organ-specific and systemic vasculitis associated with corona virus disease 2019 (COVID-19) vaccination have been reported. However, acute partial transverse myelitis (APTM) is rare adverse events following received COVID-19 vaccines. To the best of our knowledge, there is no report on vaccine-associated APTM accompanied by possible concurrent vasculitis. Herein we present a case wit...

A Phase II Trial on Osimertinib as a First-Line Treatment for EGFR Mutation-Positive Ad...
https://doi.org/10.1093/oncolo/oyac193
The Oncologist; Chihara Y, Takeda T et. al.

Oct 2nd, 2022 - Osimertinib is one of the standard first-line treatments for advanced non-small cell lung cancer in patients with epidermal growth factor receptor (EGFR) mutations, because it achieves significantly longer progression-free survival (PFS) than conventional first-line treatments (hazard ratio: 0.46). However, the efficacy and safety of osimertinib as a first-line treatment for patients aged ≥75 y...

Assessing rupture risk by hemodynamics, morphology and plasma concentrations of the sol...
https://doi.org/10.1016/j.clineuro.2022.107451
Clinical Neurology and Neurosurgery; Wei J, Xu Y et. al.

Oct 2nd, 2022 - This study investigated the relationship between morphology, hemodynamic parameters, and plasma concentrations of the soluble form of tyrosine kinase receptor Axl (sAxl) and their potential role in assessing the intracranial aneurysm rupture risk. Thirty-nine patients were retrospectively recruited and these patients were divided into low and high rupture risk groups based on the PHASES score. ...