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Supporting Adults Bereaved Through COVID-19: A Rapid Review of the Impact of Previous Pandemics on Grief and Bereavement
https://www.sciencedirect.com/science/article/pii/S0885392420303882

The global COVID-19 pandemic is likely to have a major impact on the experience of death, dying, and bereavement. This study aimed to review and synthesize learning from previous literature focused on the impact on grief and bereavement during other infectious disease outbreaks. We conducted a rapid scoping review according to the principles of the Joanna Briggs Institute and analyzed qualitati...

AASA COVID-19 RECOVERY TASK FORCE GUIDELINES FOR REOPENING SCHOOLS: An Opportunity to Transform Public Education
http://aasacentral.org/wp-content/uploads/2020/06/AASA-COVID-19-Recovery-Task-Force-Guiding-Principals-and-Action-Steps-for-Reopening-Schools.pdf

AASA, The School Superintendents Association, is committed to supporting superintendents and other school district leaders throughout the country during this challenging and unprecedented time. The following report presents a synthesis of the Guidelines for Reopening Schools recommended by superintendents throughout the United States as part of an ongoing AASA task force. During meetings of...

Protein Distribution and Muscle-Related Outcomes: Does the Evidence Support the Concept?
https://www.mdpi.com/2072-6643/12/5/1441/htm

There is a shift in thinking about dietary protein requirements from daily requirements to individual meal requirements. Per meal, stimulation of muscle protein synthesis has a saturable dose relationship with the quantity of dietary protein consumed. Protein intake above the saturable dose does not further contribute to the synthetic response; the “excess” amino acids are predominantly oxidize...

AGA Clinical Practice Guidelines on the Role of Probiotics in the Management of Gastrointestinal Disorders
https://www.gastrojournal.org/article/S0016-5085(20)34729-6/pdf

This document presents the official recommendations of the American Gastroenterological Association (AGA) on the role of probiotics in the management of gastrointestinal disorders. The guideline was developed by the AGA Institute’s Clinical Guidelines Committee and approved by the AGA Governing Board. It is accompanied by a technical review that provides a detailed synthesis of the evidence ...

Copper: Fact Sheet for Health Professionals
https://ods.od.nih.gov/factsheets/Copper-HealthProfessional/
NIH

Copper, an essential mineral, is naturally present in some foods and is available as a dietary supplement. It is a cofactor for several enzymes (known as “cuproenzymes”) involved in energy production, iron metabolism, neuropeptide activation, connective tissue synthesis, and neurotransmitter synthesis [1-3]. One abundant cuproenzyme is ceruloplasmin (CP), which plays a role in iron metabolism a...

The species-specific 282 residue in the PB2 subunit of the polymerase regulates RNA syn...
https://doi.org/10.1128/jvi.02190-21
Journal of Virology; Banerjee S, De A et. al.

Jan 20th, 2022 - Bat influenza viruses are genetically distant from classical influenza A viruses (IAV) and show distinct functional differences in their surface antigens. Nevertheless, any comparative analysis between bat and classical IAV RNA polymerases or their specific subunits are yet to be performed. In this work, we have identified signature residues present in the bat influenza virus polymerase, which ...

Congenital hypothyroidism and hyperthyroidism alters adrenal gene-expression, developme...
https://doi.org/10.1089/thy.2021.0535
Thyroid : Official Journal of the American Thyroid Associ... Patyra K, Löf C et. al.

Jan 20th, 2022 - The human adrenal cortex undergoes several rapid remodeling steps during its lifetime. In rodents, similar remodeling occurs postnatally in the 'X-zone' layer via unknown mechanisms. Furthermore, little is known regarding the impact of thyroid hormone (TH) on adrenal glands in humans. To investigate the impact of TH on adrenal pathophysiology, we created two genetic murine models mimicking huma...

Cognitive Orientation to Daily Occupational Performance (CO-OP) in Children with Cerebr...
https://doi.org/10.1177/00084174211066651
Canadian Journal of Occupational Therapy. Revue Canadienn... Roostaei M, Dalvand H et. al.

Jan 20th, 2022 - Cognitive orientation to daily occupational performance (CO-OP) is a client-centered treatment approach that was developed in the 1990s by occupational therapists. Purpose: Exploring current evidence about the effectiveness of CO-OP on children with cerebral palsy (CP). Method: Major electronic databases were searched. A narrative synthesis of current literature and meta-analyses on randomized ...

LiBr-Catalyzed C3-Disulfuration between Indole and N-Dithiophthalimide.
https://doi.org/10.1021/acs.joc.1c02556
The Journal of Organic Chemistry; Wang D, Li W et. al.

Jan 20th, 2022 - A simple, green halide-catalyzed protocol for disulfuration of indole derivatives with N-dithiophthalimides has been developed. This C-H disulfide reaction proceeded smoothly at room temperature with economical LiBr as catalyst, providing an effective method for the synthesis of novel unsymmetrical disulfides. A series of 3-dithioindole derivatives were obtained in high yields with good functio...

Perivascular Adipose Tissue Is a Major Source of Nitric Oxide in Saphenous Vein Grafts ...
https://doi.org/10.1161/JAHA.120.020637
Journal of the American Heart Association; Saito T, Kurazumi H et. al.

Jan 20th, 2022 - Background Saphenous vein grafts (SVGs) are broadly used in coronary artery bypass grafting despite their inferior patency compared with arterial grafts. Recently, the no-touch technique (NT), in which an SVG is harvested with a pedicle of perivascular adipose tissue (PVAT) without conduit distension, was shown to improve long-term patency compared with conventional preparation (CV), wherein ou...

Impact of Brain MRI on the Diagnosis of Infective Endocarditis and Treatment Decisions:...
https://doi.org/10.2214/AJR.21.26896
AJR. American Journal of Roentgenology; Ahn Y, Joo L et. al.

Jan 20th, 2022 - Background: Despite increasing use of brain MRI in patients with suspected infective endocarditis, the clinical impact of brain MRI in this setting has not yet been systematically reviewed to our knowledge. Objective: To evaluate the frequency of findings on brain MRI in patients with suspected or confirmed infective endocarditis and to determine the impact of such findings on clinical decision...

Socioeconomic factors associated with suicidal behaviors in South Korea: systematic rev...
https://doi.org/10.1186/s12889-022-12498-1 10.1521/psyc.2014.77.4.360 10.1177/1010539520940893 10.1590/s0102-311x2006000800007 10.1192/bjo.2018.88 10.1097/JOM.0b013e31820d161c 10.1023/A:1009653522950 10.1177/002076408703300307 10.1016/S0140-6736(12)61244-6 10.1016/j.jad.2016.01.011 10.1177/0020764015597015 10.4306/pi.2017.14.6.713 10.1016/j.shaw.2019.07.007 10.1136/bmjopen-2015-009451 10.1007/s00038-011-0245-9 10.1093/ije/dyl239 10.1002/gps.5166 10.1007/s11136-020-02538-x 10.1093/pubmed/fds097 10.1002/j.2051-5545.2011.tb00012.x 10.4178/epih.e2019022 10.1177/1010539514524816 10.5620/eht.e2016018 10.1017/S1041610216001149 10.1177/0004867414540752 10.1017/S1041610213001634 10.1371/journal.pone.0188019 10.1097/MD.0000000000009331 10.1027/0227-5910/a000605 10.1111/sltb.12242 10.1177/0020764018792592 10.1177/0020764006061254 10.3346/jkms.2016.31.12.2010 10.1007/s00420-017-1229-8 10.1016/j.socscimed.2010.01.004 10.1017/S1041610213002366 10.3390/ijerph16162929 10.30773/pi.2017.05.31.1 10.3390/ijerph16162811 10.3390/ijerph16234866 10.3346/jkms.2014.29.9.1287 10.4306/pi.2008.5.2.86 10.1038/s41598-019-38886-z 10.1016/j.je.2016.06.008 10.1186/s12889-015-1665-x 10.1002/ajim.23050 10.1016/j.ypmed.2014.12.017 10.1177/0020764011433626 10.1007/s10597-015-9863-7 10.1080/00332747.2016.1175837 10.3390/ijerph13121184 10.5765/jkacap.190035 10.3961/jpmph.14.030 10.1136/bmjopen-2014-007421 10.3346/jkms.2009.24.2.215 10.3961/jpmph.14.038 10.5993/AJHB.44.2.8 10.1539/joh.14-0237-OA 10.4306/pi.2015.12.1.16 10.3346/jkms.2016.31.7.1042 10.5271/sjweh.3646 10.1111/sltb.12116 10.1186/1471-2458-13-110 10.1377/hlthaff.21.2.31 10.1177/2150132720913720 10.4306/pi.2016.13.2.184 10.1136/jech-2013-202759 10.1007/s11199-005-3734-6 10.1080/14034940500489339 10.4054/DemRes.2011.24.3 10.1177/0004867418763530 10.30773/pi.2020.0166
BMC Public Health; Raschke N, Mohsenpour A et. al.

Jan 20th, 2022 - The economic and human costs of suicide to individuals, families, communities, and society make suicide a major public health problem around the world. Suicide rates in South Korea are among the highest in the world. This paper is the first systematic review investigating socioeconomic risk factors for suicidal behaviors (suicidal ideation, attempted suicides, and completed suicides) in South K...

Impact of sleep patterns upon female neuroendocrinology and reproductive outcomes: a co...
https://doi.org/10.1186/s12958-022-00889-3
Reproductive Biology and Endocrinology : RB&E; Beroukhim G, Esencan E et. al.

Jan 20th, 2022 - Sleep is vital to human bodily function. Growing evidence indicates that sleep deprivation, disruption, dysrhythmia, and disorders are associated with impaired reproductive function and poor clinical outcomes in women. These associations are largely mediated by molecular-genetic and hormonal pathways, which are crucial for the complex and time sensitive processes of hormone synthesis/secretion,...

Use of the kidney failure risk equation to inform clinical care of patients with chroni...
https://doi.org/10.1136/bmjopen-2021-055572
BMJ Open; Bhachu HK, Fenton A et. al.

Jan 20th, 2022 - The Kidney Failure Risk Equation (KFRE) predicts the risk of end-stage kidney disease in patients with chronic kidney disease (CKD). This study aimed to evaluate the impact of the utility of KFRE in clinical practice. Systematic review. Adult patients with CKD but not receiving renal replacement therapy enrolled in studies where KFRE was used in clinical care pathways. All studies published fro...

Yeast has evolved to minimize protein resource cost for synthesizing amino acids.
https://doi.org/10.1073/pnas.2114622119
Proceedings of the National Academy of Sciences of the Un... Chen Y, Nielsen J

Jan 20th, 2022 - Proteins, as essential biomolecules, account for a large fraction of cell mass, and thus the synthesis of the complete set of proteins (i.e., the proteome) represents a substantial part of the cellular resource budget. Therefore, cells might be under selective pressures to optimize the resource costs for protein synthesis, particularly the biosynthesis of the 20 proteinogenic amino acids. Previ...

Sex differences in vitamin D metabolism, serum levels and action.
https://doi.org/10.1017/S0007114522000149
The British Journal of Nutrition; Wierzbicka A, Oczkowicz M

Jan 20th, 2022 - The ubiquity of vitamin D metabolizing enzymes and vitamin D receptors in mammalian organisms suggests that vitamin D has pleiotropic effects. There are quite a few studies indicating the anticancer, cardioprotective and anti-diabetic effects of vitamin D, however, the best-documented actions of vitamin D are the regulation of calcium-phosphate balance and its effect on immune function.Vitamin ...

Green plant genomes: What we know in an era of rapidly expanding opportunities.
https://doi.org/10.1073/pnas.2115640118
Proceedings of the National Academy of Sciences of the Un... Kress WJ, Soltis DE et. al.

Jan 20th, 2022 - Green plants play a fundamental role in ecosystems, human health, and agriculture. As de novo genomes are being generated for all known eukaryotic species as advocated by the Earth BioGenome Project, increasing genomic information on green land plants is essential. However, setting standards for the generation and storage of the complex set of genomes that characterize the green lineage of life...

Asymmetric synthesis of N-bridged 3.3.1 ring systems by phosphonium salt/Lewis acid rel...
https://doi.org/10.1038/s41467-022-28001-8
Nature Communications; Tan JP, Li K et. al.

Jan 20th, 2022 - Optically pure pseudo-natural products (PNPs), particularly exemplified by azabicyclo[3.3.1]nonane molecules and their analogs provide an attractive platform for structure-activity relationship studies, and also lead new compound discovery in drug development. However, there are currently no examples of guiding catalytic asymmetric strategies available to construct such important PN-scaffolds, ...

Brønsted acid-enhanced copper-catalyzed atroposelective cycloisomerization to axially c...
https://doi.org/10.1038/s41467-022-27989-3
Nature Communications; Min XL, Zhang XL et. al.

Jan 20th, 2022 - The construction of axially chiral N-heterobiaryls is of great interest as a result of their occurrence in organocatalysts, chiral ligands, natural products, and biologically active molecules. Despite remarkable achievements in this area, strategies for the preparation of new classes of axially chiral N-heterobiaryls remain to be further explored. Herein, we report the enantioselective synthesi...

Photocatalytic defluoroalkylation and hydrodefluorination of trifluoromethyls using o-p...
https://doi.org/10.1038/s41467-022-28007-2
Nature Communications; Liu C, Shen N et. al.

Jan 19th, 2022 - Under visible light irradiation, o-phosphinophenolate functions as an easily accessible photoredox catalyst to activate trifluoromethyl groups in trifluoroacetamides, trifluoroacetates, and trifluoromethyl (hetero)arenes to deliver corresponding difluoromethyl radicals. It works in relay with a thiol hydrogen atom transfer (HAT) catalyst to enable selective defluoroalkylation and hydrodefluorin...