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Supporting Adults Bereaved Through COVID-19: A Rapid Review of the Impact of Previous Pandemics on Grief and Bereavement
https://www.sciencedirect.com/science/article/pii/S0885392420303882

The global COVID-19 pandemic is likely to have a major impact on the experience of death, dying, and bereavement. This study aimed to review and synthesize learning from previous literature focused on the impact on grief and bereavement during other infectious disease outbreaks. We conducted a rapid scoping review according to the principles of the Joanna Briggs Institute and analyzed qualitati...

AASA COVID-19 RECOVERY TASK FORCE GUIDELINES FOR REOPENING SCHOOLS: An Opportunity to Transform Public Education
http://aasacentral.org/wp-content/uploads/2020/06/AASA-COVID-19-Recovery-Task-Force-Guiding-Principals-and-Action-Steps-for-Reopening-Schools.pdf

AASA, The School Superintendents Association, is committed to supporting superintendents and other school district leaders throughout the country during this challenging and unprecedented time. The following report presents a synthesis of the Guidelines for Reopening Schools recommended by superintendents throughout the United States as part of an ongoing AASA task force. During meetings of...

Protein Distribution and Muscle-Related Outcomes: Does the Evidence Support the Concept?
https://www.mdpi.com/2072-6643/12/5/1441/htm

There is a shift in thinking about dietary protein requirements from daily requirements to individual meal requirements. Per meal, stimulation of muscle protein synthesis has a saturable dose relationship with the quantity of dietary protein consumed. Protein intake above the saturable dose does not further contribute to the synthetic response; the “excess” amino acids are predominantly oxidize...

AGA Clinical Practice Guidelines on the Role of Probiotics in the Management of Gastrointestinal Disorders
https://www.gastrojournal.org/article/S0016-5085(20)34729-6/pdf

This document presents the official recommendations of the American Gastroenterological Association (AGA) on the role of probiotics in the management of gastrointestinal disorders. The guideline was developed by the AGA Institute’s Clinical Guidelines Committee and approved by the AGA Governing Board. It is accompanied by a technical review that provides a detailed synthesis of the evidence ...

Copper: Fact Sheet for Health Professionals
https://ods.od.nih.gov/factsheets/Copper-HealthProfessional/
NIH

Copper, an essential mineral, is naturally present in some foods and is available as a dietary supplement. It is a cofactor for several enzymes (known as “cuproenzymes”) involved in energy production, iron metabolism, neuropeptide activation, connective tissue synthesis, and neurotransmitter synthesis [1-3]. One abundant cuproenzyme is ceruloplasmin (CP), which plays a role in iron metabolism a...

Augmentation of 3β-hydroxysteroid-Δ24 Reductase (DHCR24) Expression Induced by Bovine V...
https://doi.org/10.1128/jvi.01492-22
Journal of Virology; Ma Y, Han Y et. al.

Dec 6th, 2022 - Bovine viral diarrhea virus (BVDV) is the etiologic agent of bovine viral diarrhea-mucosal disease, one of the most important viral diseases of cattle, leading to numerous losses to the cattle rearing industry worldwide. The pathogenicity of BVDV is extremely complex, and many underlying mechanisms involved in BVDV-host interactions are poorly understood, especially how BVDV utilizes host metab...

Vascular dysfunction in juvenile idiopathic arthritis: a systematic review and meta-ana...
https://doi.org/10.1007/s00296-022-05255-5
Rheumatology International; Patra PK, Banday AZ et. al.

Dec 6th, 2022 - We performed a systematic review and meta-analysis of studies evaluating vascular function in patients with JIA. Relevant literature published from 1st January 1965 to 1st March 2022 was searched systematically utilizing PubMed, Web of Science, and Embase databases. Observational studies were included-patients with JIA (classified according to the International League of Associations for Rheuma...

Synthesis of β-Lactams through Carbonylation of Diazo Compounds Followed by the 2 + 2 C...
https://doi.org/10.1021/acs.joc.2c01484
The Journal of Organic Chemistry; Koothradan FF, Jayarani A et. al.

Dec 6th, 2022 - Reporting an efficient method for the synthesis of β-lactams by the carbonylation of diazo compounds, using [Co2(CO)8] to corresponding ketenes, followed by [2 + 2] cycloaddition with imines. The newly developed strategy was successfully applied to electronically and structurally diverse substrates to produce the corresponding β-lactams under mild reaction conditions. Fourier transform infrared...

Utility of angiotensin-converting enzyme and serum calcium levels in cutaneous sarcoido...
https://doi.org/10.1111/ijd.16547
International Journal of Dermatology; Evenson CJ, Rosenbach M et. al.

Dec 6th, 2022 - Sarcoidosis is a granulomatous disease of unknown etiology but is theorized to result from immune overactivity in the setting of an environmental or genetic trigger. It most commonly affects the lungs and lymph nodes but can affect other organ systems, with cutaneous involvement in 30% of patients. The granulomas associated with sarcoidosis lead to increased activity of angiotensin-converting e...

Cochrane "evidence relevant to" rehabilitation of people with post COVID-19 condition. ...
https://doi.org/10.23736/S1973-9087.22.07793-0
European Journal of Physical and Rehabilitation Medicine; Negrini S, Kiekens C et. al.

Dec 6th, 2022 - Cochrane Rehabilitation developed a series of actions to provide the global rehabilitation community with the best available evidence to respond to the COVID-19 pandemic. These initiatives constituted the REH-COVER (Rehabilitation COVID-19 evidence-based response) action. In March 2020, the first initiative started in agreement with the European Journal of Physical and Rehabilitation Medicine (...

Asymmetric Synthesis of Spiro-3,3'-cyclopropyl Oxindoles via Vinylogous Michael Initiat...
https://doi.org/10.1021/acs.joc.2c02402
The Journal of Organic Chemistry; Manna A, Joshi H et. al.

Dec 6th, 2022 - A novel organocatalytic cascade approach for the synthesis of spiro-cyclopropyl oxindole derivatives has been developed. The methodology is based on asymmetric vinylogous Michael addition of 4-nitroisoxazole derivatives to N-Boc isatylidene malonates followed by intramolecular alkylation. Its remarkable stereocontrol, wide substrate scope, and scalability highlight this new developed strategy. ...

An obesogenic diet uncovers disparate changes in UCP1 content and lipid synthesis and s...
https://doi.org/10.1113/JP284107
The Journal of Physiology; Wright DC

Dec 5th, 2022 - An obesogenic diet uncovers disparate changes in UCP1 content and lipid synthesis and storage in rat brown adipose tissue.|2022|Wright DC,|

Interleukin-10 -1082 G/A polymorphism and its association with early or severe presenta...
https://doi.org/10.1016/j.cyto.2022.156103
Cytokine Rai H, Joner M et. al.

Dec 5th, 2022 - Interleukin-10 (IL-10) is an anti-inflammatory cytokine with potent deactivating properties on macrophages and T cells; and plays an important role in atherosclerotic plaque maturation and rupture. A guanine (G) to adenine (A) substitution in the IL-10 gene at -1082 bp (rs1800896) has been associated with reduced in IL-10 production in vitro. Against this background, we tested the association o...

Immunoendocrine abnormalities in the female reproductive system, and lung steroidogenes...
https://doi.org/10.1016/j.tube.2022.102274
Tuberculosis (Edinburgh, Scotland); Ramos Robles B, Valdez RA et. al.

Dec 5th, 2022 - Tuberculosis (TB) caused by Mycobacterium tuberculosis mainly affects the lungs, but can spread to other organs. TB chronically activates the immune and endocrine systems producing remarkable functional changes.So far, it is unknown whether pulmonary non-disseminated TB cause changes in the female reproductive system and lung endocrinology. To investigate whether pulmonary TB produces immunoend...

Experiences of Women With Breast Cancer Using Telehealth: A Qualitative Systematic Review.
https://doi.org/10.1016/j.clbc.2022.11.001
Clinical Breast Cancer; Meneses AFP, Pimentel FF et. al.

Dec 5th, 2022 - Breast cancer is the most prevalent malignant neoplasm among women. Its treatment comprises different strategies. Telehealth can ensure continuity of care in distant locations. This study aimed to synthesize qualitative evidence of women's experiences with telehealth during the treatment and follow-up of breast cancer. We performed a qualitative systematic review and meta-synthesis. The databas...

Thirty years of research on negative symptoms of schizophrenia: A scientometric analysi...
https://doi.org/10.1016/j.neubiorev.2022.104979
Neuroscience and Biobehavioral Reviews; Sabe M, Chen C et. al.

Dec 5th, 2022 - Research on negative symptoms of schizophrenia has received renewed interest since the 1980s. A scientometric analysis that objectively maps scientific knowledge, with changes in recent trends, is currently lacking. We searched the Web of Science Core Collection (WOSCC) on December 17, 2021 using relevant keywords. R-bibliometrix and CiteSpace were used to perform the analysis. We retrieved 27,...

PGRMC1: An enigmatic heme-binding protein.
https://doi.org/10.1016/j.pharmthera.2022.108326
Pharmacology & Therapeutics; McGuire MR, Espenshade PJ

Dec 5th, 2022 - Progesterone Receptor Membrane Component 1 (PGRMC1) is a heme-binding protein that has been implicated in a wide range of cell and tissue functions, including cytochromes P450 activity, heme homeostasis, cancer, female reproduction, and protein quality control. Despite an extensive body of literature, a relative lack of mechanistic insight means that how PGRMC1 functions in these different aspe...

RBM24 inhibits the translation of SARS-CoV-2 polyproteins by targeting the 5'-untransla...
https://doi.org/10.1016/j.antiviral.2022.105478
Antiviral Research; Yao Y, Sun H et. al.

Dec 5th, 2022 - SARS-CoV-2 is a betacoronavirus with single-stranded positive-sense RNA, which is a serious global threat to human health. Understanding the molecular mechanism of viral replication is crucial for the development of antiviral drugs. The synthesis of viral polyproteins is a crucial step in viral progression. The synthesis of viral polyproteins in coronaviruses is regulated by the 5'-untranslated...

High thyrotropin levels and risk of mortality in the elderly with subclinical hypothyro...
https://doi.org/10.1016/j.eprac.2022.11.011
Endocrine Practice : Official Journal of the American Col... Zhong J, Mu D et. al.

Dec 5th, 2022 - This study aims to determine whether elevated endogenous thyrotropin levels contribute to an increased risk of adverse outcomes, such as all-cause mortality in older adults with subclinical hypothyroidism. Eight electronic databases were searched for relevant articles from inception until March 23, 2022. Cohort studies assessing the association between thyrotropin levels and the risk of mortali...

Compartmentalized regulation of lipid signaling in oxidative stress and inflammation: P...
https://doi.org/10.1016/j.plipres.2022.101207
Progress in Lipid Research; Astudillo AM, Balboa MA et. al.

Dec 5th, 2022 - Perturbations in lipid homeostasis combined with conditions favoring oxidative stress constitute a hallmark of the inflammatory response. In this review we focus on the most recent results concerning lipid signaling in various oxidative stress-mediated responses and inflammation. These include phagocytosis and ferroptosis. The best characterized event, common to these responses, is the synthesi...