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About 256,960 results

Copper: Fact Sheet for Health Professionals
https://ods.od.nih.gov/factsheets/Copper-HealthProfessional/
NIH

Copper, an essential mineral, is naturally present in some foods and is available as a dietary supplement. It is a cofactor for several enzymes (known as “cuproenzymes”) involved in energy production, iron metabolism, neuropeptide activation, connective tissue synthesis, and neurotransmitter synthesis [1-3]. One abundant cuproenzyme is ceruloplasmin (CP), which plays a role in iron metabolism a...

AASA COVID-19 RECOVERY TASK FORCE GUIDELINES FOR REOPENING SCHOOLS: An Opportunity to Transform Public Education
http://aasacentral.org/wp-content/uploads/2020/06/AASA-COVID-19-Recovery-Task-Force-Guiding-Principals-and-Action-Steps-for-Reopening-Schools.pdf

AASA, The School Superintendents Association, is committed to supporting superintendents and other school district leaders throughout the country during this challenging and unprecedented time. The following report presents a synthesis of the Guidelines for Reopening Schools recommended by superintendents throughout the United States as part of an ongoing AASA task force. During meetings of...

AGA Clinical Practice Guidelines on the Role of Probiotics in the Management of Gastrointestinal Disorders
https://www.gastrojournal.org/article/S0016-5085(20)34729-6/pdf

This document presents the official recommendations of the American Gastroenterological Association (AGA) on the role of probiotics in the management of gastrointestinal disorders. The guideline was developed by the AGA Institute’s Clinical Guidelines Committee and approved by the AGA Governing Board. It is accompanied by a technical review that provides a detailed synthesis of the evidence ...

Protein Distribution and Muscle-Related Outcomes: Does the Evidence Support the Concept?
https://www.mdpi.com/2072-6643/12/5/1441/htm

There is a shift in thinking about dietary protein requirements from daily requirements to individual meal requirements. Per meal, stimulation of muscle protein synthesis has a saturable dose relationship with the quantity of dietary protein consumed. Protein intake above the saturable dose does not further contribute to the synthetic response; the “excess” amino acids are predominantly oxidize...

Supporting Adults Bereaved Through COVID-19: A Rapid Review of the Impact of Previous Pandemics on Grief and Bereavement
https://www.sciencedirect.com/science/article/pii/S0885392420303882

The global COVID-19 pandemic is likely to have a major impact on the experience of death, dying, and bereavement. This study aimed to review and synthesize learning from previous literature focused on the impact on grief and bereavement during other infectious disease outbreaks. We conducted a rapid scoping review according to the principles of the Joanna Briggs Institute and analyzed qualitati...

The Assessment of Functional Movement in Children and Adolescents: A Systematic Review ...
https://doi.org/10.1007/s40279-021-01529-3 10.1007/978-3-319-21416-0 10.1186/2052-1847-5-11 10.1515/hukin-2017-0128 10.1123/jmld.2020-0013 10.1080/02640414.2015.1096017 10.3390/ijerph17072468 10.1519/JSC.0b013e3182576fa6 10.1177/0363546516641937 10.1111/j.1600-0838.2009.01038.x 10.1016/j.jsams.2017.08.001 10.1136/bmjsem-2018-000501 10.1136/bjsports-2016-096938 10.1016/j.gaitpost.2013.11.007 10.26603/ijspt20190436 10.3389/fnhum.2017.00343 10.1055/a-0781-2473 10.3390/sports5030067 10.1080/02640414.2014.918642 10.26603/ijspt20190911 10.7717/peerj.7270 10.1007/s40279-018-0892-6 10.1080/10833196.2016.1227568 10.3928/19425864-20110715-01 10.1080/03014460.2020.1737731 10.3109/17477166.2011.607458 10.1016/j.jclinepi.2009.06.006 10.1016/j.jclinepi.2007.11.008 10.1002/9780470743386 10.1186/1471-2288-14-25 10.1249/MSS.0b013e31818cb278 10.1136/bmj.327.7414.557 10.1152/japplphysiol.00098.2015 10.1080/02640414.2018.1532152 10.1016/j.jpeds.2015.06.015 10.1123/pes.2016-0278 10.1080/02701367.2018.1484066 10.3390/sports5040077 10.1123/jmld.2016-0067 10.3390/ijerph17176361 10.1519/JSC.0000000000000602 10.1155/2012/697563 10.1519/JSC.0000000000000722 10.47197/retos.v0i34.65097 10.3390/ijerph17249230 10.5040/9781492596837 10.1136/bjsports-2011-090218 10.1136/bjsports-2017-098253 10.1080/02640414.2013.828850 10.1080/02640414.2014.889846 10.1136/bjsm.2010.079616 10.1519/JSC.0000000000000733 10.1186/1479-5868-9-150 10.1080/02640414.2018.1508399 10.1177/1757975915573878 10.5812/semj.65287 10.5339/avi.2013.8 10.3961/jpmph.2013.46.S.S43 10.1080/13573322.2011.540427 10.1016/j.avdiab.2012.04.001 10.1111/j.1467-789X.2010.00750.x 10.3390/ijerph16224428 10.1123/pes.25.4.591 10.1016/j.ptsp.2017.07.001 10.1177/0363546515614585 10.3390/jfmk4020031 10.1038/ijo.2008.11 10.1371/journal.pmed.1002641 10.1097/MED.0b013e328320d54c 10.1016/j.orcp.2021.01.005 10.1016/j.gaitpost.2016.06.012 10.1111/obr.12848 10.1371/journal.pone.0140224 10.1080/02640414.2013.803587 10.1155/2011/650230 10.1007/s40279-019-01063-3 10.1080/00336297.2008.10483582 10.1007/s40279-015-0351-6
Sports Medicine (Auckland, N.Z.); O'Brien W, Khodaverdi Z et. al.

Sep 16th, 2021 - The Functional Movement Screen™ (FMS™) is an assessment of human movement that may signal potential deficits that could predispose an otherwise healthy person to injury risk. FMS™ scores are well reported in both athletic and adult samples. However, to date, there has been no comprehensive systematic review and meta-analysis of FMS™ data among school-aged children and adolescents. We aimed to s...

Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review.
https://doi.org/10.1186/s12958-021-00824-y 10.1016/j.jri.2011.04.006 10.1007/s10815-012-9861-4 10.1016/S1472-6483(10)61773-7 10.1016/j.fertnstert.2003.08.031 10.1023/B:JARG.0000006708.26464.23 10.1016/j.rbmo.2012.10.004 10.1046/j.1445-5781.2003.00031.x 10.1016/S1472-6483(10)61442-3 10.1016/j.fertnstert.2004.07.974 10.1017/S096719941100058X 10.1016/S0015-0282(00)01549-1 10.1093/humupd/dml004 10.1016/j.fertnstert.2013.05.004 10.5653/cerm.2017.44.2.105 10.1016/S0015-0282(03)01178-6 10.1002/jum.14319 10.1016/j.fertnstert.2007.05.064 10.18203/2320-1770.ijrcog20151262 10.1016/j.jogoh.2017.02.015 10.1016/j.fertnstert.2011.03.028
Reproductive Biology and Endocrinology : RB&E; Zhang J, Wang C et. al.

Sep 16th, 2021 - Sequential embryo transfer has been proposed as a way to improve embryo implantation in women for in vitro fertilization (IVF), but the effect on pregnancy outcomes remains ambiguous. This systematic review was conducted to investigate the efficacy of sequential embryo transfer on IVF outcomes. A literature search was performed in the PubMed, Web of Science, Cochrane Library, ScienceDirect and ...

Public health education by emergency nurses: A scoping review and narrative synthesis.
https://doi.org/10.1016/j.pec.2021.08.036
Patient Education and Counseling; Coombs NM, Porter JE et. al.

Sep 16th, 2021 - To identify the extent, range, and nature of the evidence on public health education provided by emergency nurses. A scoping review, using the methodological guidance of Joanna Briggs Institute, was conducted to scope and map the literature and research activity. Using predetermined criteria, databases, grey literature, and reference lists were searched for eligible sources. At least two author...

A Novel Etomidate Analogue EL-0052 Retains Potent Hypnotic Effect and Stable Hemodynami...
https://doi.org/10.1124/jpet.121.000691
The Journal of Pharmacology and Experimental Therapeutics; Xu X, Wei Y et. al.

Sep 16th, 2021 - Etomidate is a potent and rapidly acting anesthetic with high therapeutic index (TI) and superior hemodynamic stability. However, side-effect of suppressing adrenocortical function limits its clinical use. To overcome this side-effect, we designed a novel etomidate analogue EL-0052, aiming to retain beneficial properties of etomidate and avoid its disadvantage of suppressing adrenocortical ster...

Severe Acute Respiratory Syndrome Coronavirus 2: The Role of the Main Components of the...
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Inflammation Anaeigoudari A, Mollaei HR et. al.

Sep 16th, 2021 - At the end of December 2019, the COVID-19 pandemic began in Wuhan of China. COVID-19 affects different people with a wide spectrum of clinical manifestations, ranging from asymptomatic with recovery without hospitalization up to a severe acute respiratory syndrome (SARS). The innate and adaptive immunity appears responsible for the defense against the virus and recovery from the disease. The in...

Electrochemical Oxidative Difunctionalization of Alkenes to Access α-Oxygenated Ketones.
https://doi.org/10.1021/acs.joc.1c01831
The Journal of Organic Chemistry; Dai C, Shen Y et. al.

Sep 16th, 2021 - Dioxygenation of alkenes was developed by the combination of electrochemical synthesis and aerobic oxidation, leading to easy accessibility of α-oxygenated ketones in an eco-friendly fashion. Using air as the oxygen source and the absence of transition metals were the critical features of this protocol. A wide range of alkenes and N-hydroxyimides were found to be compatible and provided α-oxyge...

Electrochemical Oxidative C(sp3)-H/N-H Coupling of Diarylmethanes with Sulfoximines or ...
https://doi.org/10.1021/acs.joc.1c01647
The Journal of Organic Chemistry; Kong X, Tian Y et. al.

Sep 16th, 2021 - Herein, we report an efficient electrochemical method for the synthesis of N-alkylated sulfoximines by electrochemical oxidative C(sp3)-H/N-H coupling of sulfoximines and diarylmethanes. In addition, we used the same conditions for electrochemical dehydrogenative amination of diarylmethanes with benzophenone imine as an aminating agent. The reactions showed good functional group tolerance and a...

Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex...
https://doi.org/10.1073/pnas.2100749118
Proceedings of the National Academy of Sciences of the Un... Zhang C, Chinnappan M et. al.

Sep 16th, 2021 - Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin dryness, inflammation, and itch. A major hallmark of AD is an elevation of the immune cytokines IL-4 and IL-13. These cytokines lead to skin barrier disruption and lipid abnormalities in AD, yet the underlying mechanisms are unclear. Sebaceous glands are specialized sebum-producing epithelial cells that promote ...

Reverse circadian glucocorticoid treatment in prepubertal children with congenital adre...
https://doi.org/10.1515/jpem-2021-0540
Journal of Pediatric Endocrinology & Metabolism : JPEM; Dubinski I, Bechtold Dalla-Pozza S et. al.

Sep 16th, 2021 - Children with salt-wasting congenital adrenal hyperplasia (CAH) have an impaired function of steroid synthesis pathways. They require therapy with glucocorticoid (GC) and mineralocorticoid hormones to avoid salt-wasting crisis and other complications. Most commonly, children receive hydrocortisone thrice daily with the highest dose in the morning, mimicking the regular physiology. However, reve...

Visible-Light-Induced Transition-Metal-Free Nitrogen-Centered Radical Strategy for the ...
https://doi.org/10.1021/acs.joc.1c01834
The Journal of Organic Chemistry; Yu WQ, Xie J et. al.

Sep 16th, 2021 - A convenient and efficient visible-light-induced tandem acylation/cyclization of N-propargylindoles with aryl- or alkyl-substituted acyl oxime esters for the synthesis of 2-acyl-substituted 9H-pyrrolo[1,2-a]indoles under transition-metal-free conditions, which proceeds via nitrogen-centered radical-mediated cleavage of the C-C σ-bond in acyl oxime esters, is established. The aryl or alkyl acyl ...

RNA-binding proteins of COSMIC importance in cancer.
https://doi.org/10.1172/JCI151627
The Journal of Clinical Investigation; Choi PS, Thomas-Tikhonenko A

Sep 16th, 2021 - Herculean efforts by the Wellcome Sanger Institute, the National Cancer Institute, and the National Human Genome Research Institute to sequence thousands of tumors representing all major cancer types have yielded more than 700 genes that contribute to neoplastic growth when mutated, amplified, or deleted. While some of these genes (now included in the COSMIC Cancer Gene Census) encode proteins ...

Sustainable food systems and nutrition in the 21st century: A report from the 22nd annu...
https://doi.org/10.1093/ajcn/nqab315
The American Journal of Clinical Nutrition; Fanzo J, Rudie C et. al.

Sep 16th, 2021 - Food systems are at the center of a brewing storm consisting of a rapidly changing climate, rising hunger and malnutrition and significant social inequities. At the same time, there are vast opportunities to ensure that food systems produce healthy and safe food in equitable ways that promote environmental sustainability, especially if the world can come together at the UN Food Systems Summit i...

Design, synthesis, biological evaluation, and molecular docking of new benzofuran and i...
https://doi.org/10.1002/ddr.21880
Drug Development Research; El-Sayed NF, El-Hussieny M et. al.

Sep 16th, 2021 - Microtubules and the mitotic spindle have become an important target for cancer treatment due to their critical role in cell division. In this work, a novel series of benzofuran and indole derivatives were designed and synthesized, to be evaluated as tubulin polymerization inhibitors. 2-Acetylbenzofuran derivatives 1a,b and 3-acetylindole 1c were condensed with Wittig reagents 2a-d and Wittig-H...

Non-pharmacological measures implemented in the setting of long-term care facilities to...
https://doi.org/10.1002/14651858.CD015085.pub2
The Cochrane Database of Systematic Reviews; Stratil JM, Biallas RL et. al.

Sep 16th, 2021 - Starting in late 2019, COVID-19, caused by the novel coronavirus SARS-CoV-2, spread around the world. Long-term care facilities are at particularly high risk of outbreaks, and the burden of morbidity and mortality is very high among residents living in these facilities. To assess the effects of non-pharmacological measures implemented in long-term care facilities to prevent or reduce the transm...

Synthesis of precision antibody conjugates using proximity-induced chemistry.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419051
Theranostics Cao YJ, Yu C et. al.

Sep 16th, 2021 - Rationale: Therapeutic antibody conjugates allow for the specific delivery of cytotoxic agents or immune cells to tumors, thus enhancing the antitumor activity of these agents and minimizing adverse systemic effects. Most current antibody conjugates are prepared by nonspecific modification of antibody cysteine or lysine residues, inevitably resulting in the generation of heterogeneous conjugate...