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About 809,393 results

Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426591
Molecular Medicine (Cambridge, Mass.); Duarte RRR, Copertino DC et. al.

Sep 11th, 2021 - Vaccination programs have been launched worldwide to halt the spread of COVID-19. However, the identification of existing, safe compounds with combined treatment and prophylactic properties would be beneficial to individuals who are waiting to be vaccinated, particularly in less economically developed countries, where vaccine availability may be initially limited. We used a data-driven approach...

Prediction of the severity of colorectal lesion by fecal hemoglobin concentration obser...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384754
World Journal of Gastroenterology; Balamou C, Koïvogui A et. al.

Sep 10th, 2021 - The rate of positive tests using fecal immunochemical test (FIT) does not decrease with subsequent campaigns, but the positive predictive value of advanced neoplasia significantly decreases in subsequent campaign after a first negative test. A relationship between the fecal hemoglobin concentration (Fhb) and the opportunity to detect a colorectal cancer in subsequent campaign has been shown. To...

In vitro efficacy of Artemisia extracts against SARS-CoV-2.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424155
Virology Journal; Nie C, Trimpert J et. al.

Sep 10th, 2021 - Traditional medicines based on herbal extracts have been proposed as affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Teas and drinks containing extracts of Artemisia annua and Artemisia afra have been widely used in Africa in efforts to prevent SARS-CoV-2 infection and fight COVID-19. T...

Immunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccines.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428655
PloS One; Wisnewski AV, Redlich CA et. al.

Sep 10th, 2021 - Reverse vaccinology is an evolving approach for improving vaccine effectiveness and minimizing adverse responses by limiting immunizations to critical epitopes. Towards this goal, we sought to identify immunogenic amino acid motifs and linear epitopes of the SARS-CoV-2 spike protein that elicit IgG in COVID-19 mRNA vaccine recipients. Paired pre/post vaccination samples from N = 20 healthy adul...

Investigation of the molecular motor of muscle: from generating life in a test tube to ...
https://doi.org/10.1152/advan.00077.2021
Advances in Physiology Education; Rall JA

Sep 10th, 2021 - This article traces 60 years of investigation of the molecular motor of skeletal muscle from the 1940s through the 1990s. It started with the discovery that myosin interaction with actin in the presence of ATP caused shortening of threads of actin and myosin. In 1957, structures protruding from myosin filaments were seen for the first time and called "cross bridges." A combination of techniques...

Machine Learning augmented docking studies of aminothioureas at the SARS-CoV-2-ACE2 int...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428716
PloS One; Rola M, Krassowski J et. al.

Sep 10th, 2021 - The current pandemic outbreak clearly indicated the urgent need for tools allowing fast predictions of bioactivity of a large number of compounds, either available or at least synthesizable. In the computational chemistry toolbox, several such tools are available, with the main ones being docking and structure-activity relationship modeling either by classical linear QSAR or Machine Learning te...

Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Sy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428573
PloS One; Kulkarni R, Chen WC et. al.

Sep 10th, 2021 - COVID-19 in humans is caused by Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that belongs to the beta family of coronaviruses. SARS-CoV-2 causes severe respiratory illness in 10-15% of infected individuals and mortality in 2-3%. Vaccines are urgently needed to prevent infection and to contain viral spread. Although several mRNA- and adenovirus-based vaccines are highly effective...

Increased risk of periodontitis occurrence in patients with rheumatoid arthritis and it...
https://doi.org/10.21037/apm-21-1782
Annals of Palliative Medicine; Xiao F, Li C et. al.

Sep 8th, 2021 - Periodontitis (PD) is a chronic inflammatory disease caused by infection of the periodontal supporting tissues. Clinical studies have reported that rheumatoid arthritis (RA) patients have a higher prevalence of PD. This study aimed to explore the correlation between RA and PD. A total of 307 RA patients (RA group) and 324 healthy individuals (control group) who received physical examinations du...

Does Panoramic X-ray Induce Cytogenetic Damage to Oral Cells? A Systematic Review With ...
https://doi.org/10.21873/anticanres.15224
Anticancer Research; DE Souza DV, Suarez Alpire ME et. al.

Sep 4th, 2021 - The aim of this review was to evaluate the scientific literature regarding the cytogenetic damage in oral exfoliated cells of adult patients submitted to panoramic X-ray. An extensive search of the literature was conducted on PubMed, Scopus and Web of Science databases for all studies published until April 2021 using combinations of the following keywords: "panoramic X-ray," "DNA damage," "gene...

Gelatin Sponge as an Anchorage for Three-dimensional Culture of Colorectal Cancer Cells.
https://doi.org/10.21873/anticanres.15230
Anticancer Research; Koyama M, Osada E et. al.

Sep 4th, 2021 - Compared to two-dimensional cultures, three-dimensional (3D) cultures have many advantages in cancer studies. Nevertheless, their implementation is unsatisfactory. This study aimed to develop an anchorage-dependent 3D culture model for colorectal cancer research. Human HCT116, DLD-1 and SW620 colorectal cell lines were cultured in a gelatin sponge, and its applicability for morphological examin...

Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy.
https://doi.org/10.1038/s41467-021-25561-z 10.1038/nrc2067 10.1038/nrd4333 10.1038/natrevmats.2016.75 10.1016/j.addr.2009.02.005 10.1089/ars.2013.5302 10.1021/acsnano.7b05215 10.1038/s41467-017-01050-0 10.1002/adfm.201800145 10.1021/acsnano.7b06852 10.1002/anie.201701181 10.1021/acsnano.5b06175 10.1002/advs.201801733 10.1038/s41467-018-08234-2 10.1016/j.isci.2019.03.008 10.1002/anie.201915118 10.1038/nature21375 10.1016/j.cmet.2014.01.002 10.1038/nature24057 10.1038/s41587-019-0377-7 10.1126/science.aad4017 10.1002/adfm.200901493 10.1002/adma.201103521 10.1016/j.biomaterials.2019.05.009 10.1021/acsnano.9b07789 10.1021/acs.nanolett.9b03340 10.1016/j.biomaterials.2019.119498 10.1016/j.biomaterials.2020.119911 10.1107/S0909049513003671 10.1021/acs.langmuir.6b01483 10.1038/s41598-017-08988-7 10.1126/science.aaf1559 10.1016/j.biomaterials.2018.02.041 10.1002/anie.200461119 10.1021/ja0380852 10.1002/adma.201704490 10.1002/adma.201504782
Nature Communications; Qin X, Wu C et. al.

Sep 4th, 2021 - Peroxisome, a special cytoplasmic organelle, possesses one or more kinds of oxidases for hydrogen peroxide (H2O2) production and catalase for H2O2 degradation, which serves as an intracellular H2O2 regulator to degrade toxic peroxides to water. Inspired by this biochemical pathway, we demonstrate the reactive oxygen species (ROS) induced tumor therapy by integrating lactate oxidase (LOx) and ca...

The need for robust characterization of nanomaterials for nanomedicine applications.
https://doi.org/10.1038/s41467-021-25584-6 10.1038/s41565-019-0496-9 10.1038/s41467-018-06730-z 10.1073/pnas.0805135105 10.1016/j.tibtech.2018.02.014 10.1038/s41565-021-00860-0 10.1021/nn300223w 10.1038/nnano.2016.168 10.1021/ja107583h 10.1152/jappl.1987.63.3.1003 10.1021/acs.analchem.9b05101 10.1107/S090744490000679X 10.1021/acsnano.6b00053 10.1038/s41467-020-20884-9 10.1016/j.impact.2017.12.004 10.1038/s41565-018-0246-4 10.1126/science.aab2374 10.1038/s41565-019-0498-7 10.1038/nnano.2013.204 10.1038/nrd3439-c1 10.1001/jama.2017.0549 10.1038/s41551-018-0314-y 10.1021/cr100440g
Nature Communications; Mahmoudi M

Sep 4th, 2021 - The need for robust characterization of nanomaterials for nanomedicine applications.|2021|Mahmoudi M,|standards,chemistry,standards,therapeutic use,chemistry,standards,therapeutic use,standards,

The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structura...
https://doi.org/10.1038/s41467-021-25537-z 10.1126/sciadv.1500106 10.1126/science.1106753 10.1073/pnas.1706139114 10.1128/mBio.01275-14 10.1038/srep10333 10.1128/mBio.00272-17 10.1016/j.pbiomolbio.2019.11.002 10.1021/acsinfecdis.8b00225 10.15252/emmm.202013207 10.1126/science.aay0967 10.1038/s41467-019-13122-4 10.1126/science.aaf2477 10.1021/bi060192w 10.1016/j.bbagen.2014.10.005 10.1016/j.febslet.2014.03.036 10.3389/fcimb.2012.00047 10.1016/j.bbabio.2011.06.016 10.1021/bi700862u 10.1074/jbc.270.27.16213 10.1016/j.bbabio.2012.06.009 10.1007/s00239-005-0005-7 10.1073/pnas.1708628114 10.1002/1873-3468.13749 10.1016/j.bbabio.2020.148175 10.1021/acsinfecdis.9b00449 10.1371/journal.pone.0015803 10.1016/0022-2836(80)90283-1 10.1016/S0076-6879(09)64011-8 10.1038/nmeth.4193 10.1016/j.jsb.2015.08.008 10.1016/j.jsb.2012.09.006 10.1107/S0907444910007493 10.1107/S0907444909052925 10.1107/S0907444909042073 10.1002/pro.3235 10.1186/1758-2946-5-39 10.1093/nar/gkq366 10.1002/jcc.23702 10.1021/ct100578z 10.1021/ct300400x 10.1016/j.bpj.2014.09.007 10.1063/1.445869 10.1021/jp101759q 10.1002/jcc.23422 10.1016/0263-7855(96)00018-5 10.1002/jcc.21787 10.1016/j.softx.2015.06.001 10.1063/1.464397 10.1002/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H 10.1063/1.448118 10.1103/PhysRevA.31.1695 10.1063/1.328693
Nature Communications; Safarian S, Opel-Reading HK et. al.

Sep 4th, 2021 - New drugs are urgently needed to combat the global TB epidemic. Targeting simultaneously multiple respiratory enzyme complexes of Mycobacterium tuberculosis is regarded as one of the most effective treatment options to shorten drug administration regimes, and reduce the opportunity for the emergence of drug resistance. During infection and proliferation, the cytochrome bd oxidase plays a crucia...

Electrode pooling can boost the yield of extracellular recordings with switchable silic...
https://doi.org/10.1038/s41467-021-25443-4 10.1038/nature24636 10.1021/acs.nanolett.6b02673 10.1016/j.neuron.2019.08.011 10.1109/JRPROC.1949.232969 10.1109/TBCAS.2010.2041350 10.1109/JSSC.2003.819174 10.3390/s17102388 10.1039/C5TB00108K 10.1039/C5LC00133A 10.1109/TBCAS.2016.2646901 10.1097/00004647-200110000-00001 10.1109/JMEMS.2012.2206564 10.1109/PROC.1968.6458 10.1152/jn.2000.84.1.401 10.1523/JNEUROSCI.0656-12.2012 10.1088/0954-898X_9_4_001 10.7554/eLife.55167 10.1109/MSP.2008.4408439 10.1109/JSSC.2005.858479 10.1109/TBCAS.2014.2359180 10.1109/JMEMS.2011.2167661 10.1109/JSSC.2017.2686580 10.3390/jlpea9030026 10.1016/j.jneumeth.2016.02.022
Nature Communications; Lee KH, Ni YL et. al.

Sep 4th, 2021 - State-of-the-art silicon probes for electrical recording from neurons have thousands of recording sites. However, due to volume limitations there are typically many fewer wires carrying signals off the probe, which restricts the number of channels that can be recorded simultaneously. To overcome this fundamental constraint, we propose a method called electrode pooling that uses a single wire to...

Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protecti...
https://doi.org/10.1038/s41467-021-25382-0 10.1056/NEJMoa2024671 10.1038/s41586-020-2607-z 10.15585/mmwr.mm6950e2 10.1056/NEJMoa2028436 10.1016/S0140-6736(21)00234-8 10.1093/infdis/jiu648 10.1016/j.immuni.2020.11.015 10.1016/j.ebiom.2016.01.029 10.1371/journal.ppat.1009025 10.1172/JCI99005 10.3389/fimmu.2019.01134 10.1073/pnas.2003138117 10.1097/QAD.0b013e3283624305 10.4049/jimmunol.1102390 10.1586/14760584.2015.965690 10.1038/s41564-020-00813-8 10.1126/science.abc4776
Nature Communications; Marlin R, Godot V et. al.

Sep 3rd, 2021 - Achieving sufficient worldwide vaccination coverage against SARS-CoV-2 will require additional approaches to currently approved viral vector and mRNA vaccines. Subunit vaccines may have distinct advantages when immunizing vulnerable individuals, children and pregnant women. Here, we present a new generation of subunit vaccines targeting viral antigens to CD40-expressing antigen-presenting cells...

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vacc...
https://doi.org/10.1073/pnas.2106433118
Proceedings of the National Academy of Sciences of the Un... King HAD, Joyce MG et. al.

Sep 3rd, 2021 - Emergence of novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need for next-generation vaccines able to elicit broad and durable immunity. Here we report the evaluation of a ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein (RFN) adjuvanted with Army Liposomal Formulation QS-21 (ALFQ). RFN vacci...

Using an asymmetric crosslinked polyethylene liner in primary total hip arthroplasty is...
https://doi.org/10.1302/0301-620X.103B9.BJJ-2021-0365.R1
The Bone & Joint Journal; Davis ET, Pagkalos J et. al.

Sep 2nd, 2021 - The aim of our study was to investigate the effect of asymmetric crosslinked polyethylene liner use on the risk of revision of cementless and hybrid total hip arthroplasties (THAs). We undertook a registry study combining the National Joint Registry dataset with polyethylene manufacturing characteristics as supplied by the manufacturers. The primary endpoint was revision for any reason. We perf...

Neural signatures of hyperdirect pathway activity in Parkinson's disease.
https://doi.org/10.1038/s41467-021-25366-0 10.1016/j.neuroimage.2010.11.063 10.1093/brain/awq332 10.1093/brain/awf156 10.1093/brain/aww048 10.1016/0166-2236(89)90074-X 10.1001/archneur.64.1.20 10.1016/0166-2236(90)90110-V 10.1016/S0168-0102(02)00027-5 10.1523/JNEUROSCI.0519-07.2007 10.1523/JNEUROSCI.4674-12.2013 10.1016/S1388-2457(00)00532-0 10.1523/JNEUROSCI.1327-18.2018 10.1016/j.neuroimage.2011.11.082 10.1016/j.neuroimage.2017.07.012 10.1038/s41587-019-0244-6 10.1371/journal.pcbi.1004609 10.1371/journal.pcbi.1002124 10.1126/science.1167093 10.1523/JNEUROSCI.21-03-01033.2001 10.1136/jnnp.2010.217489 10.3389/fnhum.2012.00155 10.1111/j.1460-9568.2006.04717.x 10.1016/j.expneurol.2008.11.008 10.1152/jn.00697.2006 10.1016/j.expneurol.2008.05.008 10.1038/srep34930 10.1523/JNEUROSCI.5459-09.2010 10.1016/j.neuroimage.2013.05.084 10.1016/j.neuron.2009.09.009 10.1523/JNEUROSCI.0817-10.2010 10.1093/brain/awr332 10.1038/nn.3997 10.1523/JNEUROSCI.0431-18.2018 10.1038/nrn2478 10.1016/j.tins.2007.05.004 10.1016/j.neuroimage.2011.01.017 10.1016/j.neuroimage.2011.07.048 10.1523/JNEUROSCI.2348-16.2016 10.1016/j.neuroimage.2011.12.044 10.1038/nrn2961 10.1093/cercor/bhn059 10.1016/S0079-6123(06)60008-3 10.1016/j.neuron.2020.02.012 10.3389/fnsys.2011.00030 10.1016/S0165-0270(03)00129-8 10.1016/j.neuron.2020.04.017 10.1093/cercor/bhi084 10.1016/j.neuron.2012.09.032 10.1088/1741-2552/aad0fb 10.1093/brain/awv018 10.1016/j.neuron.2017.08.038 10.1093/brain/awg267 10.1523/JNEUROSCI.5295-07.2008 10.1002/mds.27524 10.1016/j.expneurol.2005.11.019 10.1002/mds.20957 10.1002/mds.22054 10.1002/mds.26500 10.1227/NEU.0b013e3182676b91 10.1016/j.clinph.2017.08.028 10.1111/ner.12348 10.1212/WNL.38.9.1402 10.1001/jamaneurol.2017.3762 10.1016/j.neuroimage.2013.09.069 10.1016/S0006-3495(99)77236-X 10.1038/s41593-020-00744-x 10.1073/pnas.98.2.694 10.1016/j.neuroimage.2018.08.068
Nature Communications; Oswal A, Cao C et. al.

Sep 2nd, 2021 - Parkinson's disease (PD) is characterised by the emergence of beta frequency oscillatory synchronisation across the cortico-basal-ganglia circuit. The relationship between the anatomy of this circuit and oscillatory synchronisation within it remains unclear. We address this by combining recordings from human subthalamic nucleus (STN) and internal globus pallidus (GPi) with magnetoencephalograph...

A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hy...
https://doi.org/10.1038/s41467-021-25253-8 10.1016/j.cell.2012.05.003 10.1038/nature11112 10.1038/nrg3724 10.1016/j.cell.2017.05.045 10.1038/s41580-019-0168-5 10.1038/2181066a0 10.1126/sciadv.aay3335 10.1038/s41586-020-2500-9 10.1038/nature17640 10.1038/nature14234 10.15252/embr.201743967 10.1021/ja513080v 10.1038/nsmb.3148 10.1016/j.cell.2017.03.031 10.1016/j.celrep.2018.05.077 10.1016/j.dnarep.2019.03.015 10.1002/anie.201710209 10.1016/j.pnmrs.2019.05.002 10.1021/cr0404287 10.1016/j.jmr.2014.01.008 10.1021/jacs.9b10939 10.1038/nsmb.2294 10.1038/ncomms14902 10.1093/nar/gkh572 10.1021/bi00717a013 10.1016/S0021-9258(17)38193-0 10.1073/pnas.0907195106 10.1021/ja409835y 10.1021/ja3001419 10.1007/s10858-012-9640-7 10.1063/1.1744152 10.1038/nsb1101-932 10.1038/nature14227 10.1073/pnas.2004317117 10.1038/s41467-018-05243-z 10.1016/j.jmr.2016.10.015 10.1021/ja00062a082 10.1093/nar/9.2.267 10.1093/nar/13.13.4811 10.2174/1570162052772924 10.1038/nature11498 10.1093/nar/gkz498 10.1073/pnas.1703507114 10.1038/nchem.2877 10.1038/s41588-019-0549-x 10.1038/s41467-019-11826-1 10.1074/jbc.R200023200 10.1002/j.1460-2075.1988.tb03101.x 10.1038/s41580-018-0078-y 10.1093/nar/gkg633 10.1038/nchembio.1654 10.1073/pnas.92.8.3091 10.1007/BF00197809 10.1021/ja2117816 10.1038/nature09775 10.1021/ja8091399 10.1016/j.jmr.2014.04.010 10.1002/anie.202000493 10.1007/s10858-017-0099-4 10.1007/s10858-017-0104-y 10.1038/328089a0 10.1002/0471142700.nc0720s59 10.1038/nnano.2010.275 10.1073/pnas.101523498 10.1093/nar/gkg680 10.1021/ct600329w 10.1007/s10858-015-9970-3 10.1038/s41467-020-19371-y 10.1002/(SICI)1097-461X(1997)61:2<207::AID-QUA3>3.0.CO;2-# 10.1021/jacs.9b10535 10.1021/j100099a022 10.1021/bi00050a016 10.1093/nar/28.1.235 10.1093/nar/gkv541 10.1017/S1355838201002515
Nature Communications; Liu B, Shi H et. al.

Sep 2nd, 2021 - N6-methyladenosine (m6A) is a post-transcriptional modification that controls gene expression by recruiting proteins to RNA sites. The modification also slows biochemical processes through mechanisms that are not understood. Using temperature-dependent (20°C-65°C) NMR relaxation dispersion, we show that m6A pairs with uridine with the methylamino group in the anti conformation to form a Watson-...

Tempering of cocoa butter and chocolate using minor lipidic components.
https://doi.org/10.1038/s41467-021-25206-1 10.1007/BF02577842 10.1039/C1SM06234D 10.1016/S0009-2509(00)00458-9 10.1111/j.1365-2621.2004.tb09933.x 10.1007/BF02663754 10.5539/jfr.v7n5p86 10.1007/s11746-011-1819-7 10.1007/s11746-007-1130-9 10.1007/BF02641273 10.1002/ejlt.201100088 10.1021/acs.cgd.8b01268 10.1007/BF02637399 10.1021/cg025580l 10.1007/BF02638052 10.1007/s11746-000-0122-5 10.1111/j.1365-2621.2005.tb11491.x 10.1107/S1600577516010195 10.1046/j.1365-2818.2002.01010.x
Nature Communications; Chen J, Ghazani SM et. al.

Sep 2nd, 2021 - Chocolate manufacture includes a complex tempering procedure to direct the crystallization of cocoa butter towards the formation of fat crystal networks with specific polymorphism, nano- and microstructure, melting behavior, surface gloss and mechanical properties. Here we investigate the effects of adding various minor non-triglyceride lipidic components to refined cocoa butter and chocolate o...