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About 638,382 results

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus.
https://doi.org/10.1056/NEJMoa1803760
The New England Journal of Medicine; Fenske W, Refardt J et. al.

Aug 1st, 2018 - The indirect water-deprivation test is the current reference standard for the diagnosis of diabetes insipidus. However, it is technically cumbersome to administer, and the results are often inaccurate. The current study compared the indirect water-deprivation test with direct detection of plasma copeptin, a precursor-derived surrogate of arginine vasopressin. From 2013 to 2017, we recruited 156...

Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally ad...
https://doi.org/10.1016/S1470-2045(17)30111-0
The Lancet. Oncology; Thuss-Patience PC, Shah MA et. al.

Mar 27th, 2017 - Although trastuzumab plus chemotherapy is the standard of care for first-line treatment of HER2-positive advanced gastric cancer, there is no established therapy in the second-line setting. In GATSBY, we examined the efficacy and tolerability of trastuzumab emtansine in patients previously treated for HER2-positive advanced gastric cancer (unresectable, locally advanced, or metastatic gastric c...

Systematic review with meta-analysis: enteral nutrition therapy for the induction of re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798240
Alimentary Pharmacology & Therapeutics; Swaminath A, Feathers A et. al.

Aug 17th, 2017 - Despite potential adverse-events in a paediatric population, corticosteroids are used to induce remission in paediatric Crohn's disease. Exclusive enteral nutrition also induces remission, but is infrequently used in the USA because corticosteroids are considered the superior therapy. New data have become available since the publication of the most recent meta-analysis in 2007. To see if curren...

Neoadjuvant carboplatin in patients with triple-negative and HER2-positive early breast...
https://doi.org/10.1016/S1470-2045(14)70160-3
The Lancet. Oncology; von Minckwitz G, Schneeweiss A et. al.

May 5th, 2014 - Preclinical data suggest that triple-negative breast cancers are sensitive to interstrand crosslinking agents, and that synergy may exist for the combination of a taxane, trastuzumab, and a platinum salt for HER2-positive breast cancer. We therefore aimed to assess the efficacy of the addition of carboplatin to neoadjuvant therapy for triple-negative and HER2-positive breast cancer. Patients wi...

Accelerated methotrexate, vinblastine, doxorubicin, and cisplatin is safe, effective, a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050203
Journal of Clinical Oncology : Official Journal of the Am... Plimack ER, Hoffman-Censits JH et. al.

May 13th, 2014 - Neoadjuvant cisplatin-based chemotherapy is standard of care for muscle-invasive bladder cancer (MIBC); however, it is infrequently adopted in practice because of concerns regarding toxicity and delay to cystectomy. We hypothesized that three cycles of neoadjuvant accelerated methotrexate, vinblastine, doxorubicin, and cisplatin (AMVAC) would be safe, shorten the time to surgery, and yield simi...

Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy.
https://doi.org/10.1056/NEJMoa1307362
The New England Journal of Medicine; Navon Elkan P, Pierce SB et. al.

Feb 20th, 2014 - Polyarteritis nodosa is a systemic necrotizing vasculitis with a pathogenesis that is poorly understood. We identified six families with multiple cases of systemic and cutaneous polyarteritis nodosa, consistent with autosomal recessive inheritance. In most cases, onset of the disease occurred during childhood. We carried out exome sequencing in persons from multiply affected families of Georgia...

A test for Creutzfeldt-Jakob disease using nasal brushings.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186748
The New England Journal of Medicine; Orrú CD, Bongianni M et. al.

Aug 7th, 2014 - Definite diagnosis of sporadic Creutzfeldt-Jakob disease in living patients remains a challenge. A test that detects the specific marker for Creutzfeldt-Jakob disease, the prion protein (PrP(CJD)), by means of real-time quaking-induced conversion (RT-QuIC) testing of cerebrospinal fluid has a sensitivity of 80 to 90% for the diagnosis of sporadic Creutzfeldt-Jakob disease. We have assessed the ...

Granulocyte colony-stimulating factor in severe alcoholic hepatitis: a randomized pilot...
https://doi.org/10.1038/ajg.2014.154
The American Journal of Gastroenterology; Singh V, Sharma AK et. al.

Jun 17th, 2014 - Severe alcoholic hepatitis has high short-term mortality. The aim of this study was to test the hypothesis that treatment of patients with alcoholic hepatitis with granulocyte colony-stimulating factor (G-CSF) might mobilize bone marrow-derived stem cells and promote hepatic regeneration and thus improve survival. Forty-six patients with severe alcoholic hepatitis were prospectively randomized ...

Parity, lactation, and breast cancer subtypes in African American women: results from t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271113
Journal of the National Cancer Institute; Palmer JR, Viscidi E et. al.

Sep 16th, 2014 - African American (AA) women have a disproportionately high incidence of estrogen receptor-negative (ER-) breast cancer, a subtype with a largely unexplained etiology. Because childbearing patterns also differ by race/ethnicity, with higher parity and a lower prevalence of lactation in AA women, we investigated the relation of parity and lactation to risk of specific breast cancer subtypes. Ques...

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214273
Nature Qiu X, Wong G et. al.

Aug 29th, 2014 - Without an approved vaccine or treatments, Ebola outbreak management has been limited to palliative care and barrier methods to prevent transmission. These approaches, however, have yet to end the 2014 outbreak of Ebola after its prolonged presence in West Africa. Here we show that a combination of monoclonal antibodies (ZMapp), optimized from two previous antibody cocktails, is able to rescue ...

The efficacy of lapatinib and capecitabine in HER-2 positive breast cancer with brain m...
https://doi.org/10.1016/j.ejca.2017.07.024
European Journal of Cancer (Oxford, England : 1990); Petrelli F, Ghidini M et. al.

Aug 15th, 2017 - Breast cancer (BC) with HER-2/neu overexpression or amplification (HER-2+) is associated with a higher prevalence of brain metastases (BMs) when compared to other subtypes. Among approved drugs for HER-2+ BC, lapatinib (L) is associated with single agent activity toward BMs. We conducted a systematic review to determine the efficacy of L, singly or in combination with capecitabine (C), as a tre...

Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056593
Nature Genetics; Shi J, Yang XR et. al.

Apr 1st, 2014 - Although CDKN2A is the most frequent high-risk melanoma susceptibility gene, the underlying genetic factors for most melanoma-prone families remain unknown. Using whole-exome sequencing, we identified a rare variant that arose as a founder mutation in the telomere shelterin gene POT1 (chromosome 7, g.124493086C>T; p.Ser270Asn) in five unrelated melanoma-prone families from Romagna, Italy. Carri...

POT1 loss-of-function variants predispose to familial melanoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266105
Nature Genetics; Robles-Espinoza CD, Harland M et. al.

Apr 1st, 2014 - Deleterious germline variants in CDKN2A account for around 40% of familial melanoma cases, and rare variants in CDK4, BRCA2, BAP1 and the promoter of TERT have also been linked to the disease. Here we set out to identify new high-penetrance susceptibility genes by sequencing 184 melanoma cases from 105 pedigrees recruited in the UK, The Netherlands and Australia that were negative for variants ...

Tamoxifen for prevention of breast cancer: extended long-term follow-up of the IBIS-I b...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772450
The Lancet. Oncology; Cuzick J, Sestak I et. al.

Dec 16th, 2014 - Four previously published randomised clinical trials have shown that tamoxifen can reduce the risk of breast cancer in healthy women at increased risk of breast cancer in the first 10 years of follow-up. We report the long-term follow-up of the IBIS-I trial, in which the participants and investigators remain largely masked to treatment allocation. In the IBIS-I randomised controlled trial, prem...

Equivalency of fecal immunochemical tests and colonoscopy in familial colorectal cancer...
https://doi.org/10.1053/j.gastro.2014.08.004
Gastroenterology Quintero E, Carrillo M et. al.

Aug 16th, 2014 - Colonoscopy is the recommended screening procedure for first-degree relatives of patients with colorectal cancer (CRC), but few studies have compared its efficacy for CRC detection with that of other screening strategies. We conducted a controlled randomized trial to compare the efficacy of repeated fecal immunochemical tests (FITs) and colonoscopy in detecting advanced neoplasia (advanced aden...

Adverse reactions to sunscreen agents: epidemiology, responsible irritants and allergen...
https://doi.org/10.1097/DER.0000000000000079
Dermatitis : Contact, Atopic, Occupational, Drug; Heurung AR, Raju SI et. al.

Nov 10th, 2014 - Sunscreen is a key component in the preventive measures recommended by dermatologists and public health campaigns aimed at reducing sunburn, early skin aging, and skin cancer. To maximize compliance, adverse reactions to sunscreens should be minimized. Although inactive ingredients cause many of these reactions, it is important for dermatologists to be aware of reactions to active ultraviolet f...

Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional sur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374103
The Lancet. Infectious Diseases; Tun KM, Imwong M et. al.

Feb 23rd, 2015 - Emergence of artemisinin resistance in southeast Asia poses a serious threat to the global control of Plasmodium falciparum malaria. Discovery of the K13 marker has transformed approaches to the monitoring of artemisinin resistance, allowing introduction of molecular surveillance in remote areas through analysis of DNA. We aimed to assess the spread of artemisinin-resistant P falciparum in Myan...

Clinical safety and activity of pembrolizumab in patients with malignant pleural mesoth...
https://doi.org/10.1016/S1470-2045(17)30169-9
The Lancet. Oncology; Alley EW, Lopez J et. al.

Mar 15th, 2017 - Malignant pleural mesothelioma is a highly aggressive cancer with poor prognosis and few treatment options following progression on platinum-containing chemotherapy. We assessed the safety and efficacy of pembrolizumab (an anti-programmed cell death receptor 1 [PD-1] antibody) in advanced solid tumours expressing programmed cell death ligand 1 (PD-L1) and report here on the interim analysis of ...

Cow's Milk Contamination of Human Milk Purchased via the Internet.
https://doi.org/10.1542/peds.2014-3554
Pediatrics Keim SA, Kulkarni MM et. al.

Apr 7th, 2015 - The US Food and Drug Administration recommends against feeding infants human milk from unscreened donors, but sharing milk via the Internet is growing in popularity. Recipient infants risk the possibility of consuming contaminated or adulterated milk. Our objective was to test milk advertised for sale online as human milk to verify its human origin and to rule out contamination with cow's milk....

BOB CAT: A Large-Scale Review and Delphi Consensus for Management of Barrett's Esophagu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436697
The American Journal of Gastroenterology; Bennett C, Moayyedi P et. al.

Apr 14th, 2015 - Barrett's esophagus (BE) is a common premalignant lesion for which surveillance is recommended. This strategy is limited by considerable variations in clinical practice. We conducted an international, multidisciplinary, systematic search and evidence-based review of BE and provided consensus recommendations for clinical use in patients with nondysplastic, indefinite, and low-grade dysplasia (LG...