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About 863,730 results

Formulation, Evaluation, and Characterization of Ibuprofen Nanocrystals Tablets with Co...
https://www.ncbi.nlm.nih.gov/pubmed/36720063
International Journal of Pharmaceutical Compounding; Chauhan NN, Patel JK

Feb 1st, 2023 - The objective of this study was to prepare and evaluate ibuprofen nanocrystals using isopropyl alcohol and stabilizer sodium lauryl sulphate by way of the precipitation method. The nanocrystals were prepared by the bottom-up approach of the precipitation technique. This technique involves the use of an organic phase, which is completely miscible in the external aqueous phase. The ratio used for...

Design and Development of Agglomerated Isomalt.
https://www.ncbi.nlm.nih.gov/pubmed/36720065
International Journal of Pharmaceutical Compounding; Chauhan NN, Patel JK

Feb 1st, 2023 - The objective of this study was to prepare agglomerated isomalt by using the melt granulation process. This method involved the use of 99.5% of isomalt with the meltable binder glyceryl monostearate in a concentration of 0.5%. Glyceryl monostearate has a melting point of 50°C to 55°C, therefore, glyceryl monostearate was melted at its melting point and isomalt powder was blended with it to brea...

Mechanical performance of porous biomimetic intervertebral body fusion devices: an in v...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885572
Journal of Orthopaedic Surgery and Research; Tsuang FY, Li MJ et. al.

Feb 1st, 2023 - Degenerative disc disease is one of the most common ailments severely affecting the quality of life in elderly population. Cervical intervertebral body fusion devices are utilized to provide stability after surgical intervention for cervical pathology. In this study, we design a biomimetic porous spinal cage, and perform mechanical simulations to study its performances following American Societ...

Cytotoxicity and reactive oxygen species production induced by different co-monomer elu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887763
BMC Oral Health; Jiang ES, Moon W et. al.

Feb 1st, 2023 - Safety issues for dental restorative composites are critical to material selection, but, limited information is available to dental practitioners. This study aimed to compare the chemical and biological characteristics of three nanohybrid dental composites by assessing filler particle analysis, monomer degree of conversion (DC), the composition of eluates, and cytotoxicity and reactive oxygen s...

Improving curcumin bactericidal potential against multi-drug resistant bacteria via its...
https://doi.org/10.1080/10717544.2022.2159587
Drug Delivery; Jabbar A, Rehman K et. al.

Feb 1st, 2023 - Multi-drug resistant (MDR) bactearial strains have posed serious health issues, thus leading to a significant increase in mortality, morbidity, and the expensive treatment of infections. Metal-organic frameworks (MOFs), comprising metal ions and a variety of organic ligands, have been employed as an effective drug deliveryy vehicle due to their low toxicity, biodegradability, higher structural ...

An Overview of Polymeric Nanoparticles-Based Drug Delivery System in Cancer Treatment.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893377
Technology in Cancer Research & Treatment; Dristant U, Mukherjee K et. al.

Feb 1st, 2023 - Cancer is recognized as one of the world's deadliest diseases, with more than 10 million new cases each year. Over the past 2 decades, several studies have been performed on cancer to pursue solutions for effective treatment. One of the vital benefits of utilizing nanoparticles (NPs) in cancer treatment is their high adaptability for modification and amalgamation of different physicochemical pr...

New 1,2,4triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synth...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886266
PloS One; Gaber AA, Sobhy M et. al.

Jan 31st, 2023 - Fifteen quinazoline derivatives were designed and synthesized as DNA intercalators. The cytotoxicity of the designed members was assessed against HCT-116 and HepG2 cancer cell lines. In addition, the topoisomerase II (Topo II) inhibitory effect was assessed. Compound 16 was the most cytotoxic and Topo II inhibitor with low cytotoxicity against Vero cells. Compounds 16, 17, and 18 showed signifi...

Exocytosis of the silicified cell wall of diatoms involves extensive membrane disintegr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886994
Nature Communications; de Haan D, Aram L et. al.

Jan 31st, 2023 - Diatoms are unicellular algae characterized by silica cell walls. These silica elements are known to be formed intracellularly in membrane-bound silica deposition vesicles and exocytosed after completion. How diatoms maintain membrane homeostasis during the exocytosis of these large and rigid silica elements remains unknown. Here we study the membrane dynamics during cell wall formation and exo...

Regioselective protein oxidative cleavage enabled by enzyme-like recognition of an inor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887005
Nature Communications; Abdelhameed SAM, de Azambuja F et. al.

Jan 31st, 2023 - Oxidative modifications of proteins are key to many applications in biotechnology. Metal-catalyzed oxidation reactions efficiently oxidize proteins but with low selectivity, and are highly dependent on the protein surface residues to direct the reaction. Herein, we demonstrate that discrete inorganic ligands such as polyoxometalates enable an efficient and selective protein oxidative cleavage. ...

Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886975
Nature Communications; Chen Y, Zhou Q et. al.

Jan 31st, 2023 - Members of the insulin superfamily regulate pleiotropic biological processes through two types of target-specific but structurally conserved peptides, insulin/insulin-like growth factors and relaxin/insulin-like peptides. The latter bind to the human relaxin family peptide receptors (RXFPs). Here, we report three cryo-electron microscopy structures of RXFP4-Gi protein complexes in the presence ...

Evaluation of Chitosan-Oleuropein Nanoparticles on the Durability of Dentin Bonding.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879028
Drug Design, Development and Therapy; Zhao S, Zhang Y et. al.

Jan 31st, 2023 - To evaluate the effects of dentin pretreatment with chitosan-loaded oleuropein nanoparticles (CONPs) on the durability of resin-dentin bonding interfaces. Eighty freshly extracted non-carious human third molars were randomly divided into four groups (n = 20 each): a de-ionized water (DW) group, a chitosan (CS) group, a chlorhexidine (CHX) group and a CONP group. The dentin in the DW, CS, CHX, a...

Forming, Confining, and Observing Microtubule-Based Active Nematics.
https://doi.org/10.3791/64287
Journal of Visualized Experiments : JoVE; Memarian FL, Khaladj DA et. al.

Jan 31st, 2023 - The formation of biopolymer-based active phases has become an important technique for researchers interested in exploring the emerging field of active liquid crystals and their possible roles in cell biology. These novel systems consist of self-driven sub-units that consume energy locally, producing an out-of-equilibrium dynamic fluid. To form the active liquid crystal phase described in this r...

Customizing delivery nano-vehicles for precise brain tumor therapy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883977
Journal of Nanobiotechnology; Miao YB, Zhao W et. al.

Jan 29th, 2023 - Although some tumor has become a curable disease for many patients, involvement of the central nervous system (CNS) is still a major concern. The blood-brain barrier (BBB), a special structure in the CNS, protects the brain from bloodborne pathogens via its excellent barrier properties and hinders new drug development for brain tumor. Recent breakthroughs in nanotechnology have resulted in vari...

Clear cell stromal tumor of the lung with multinucleated giant cells: a report of a cas...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881279
Diagnostic Pathology; Jakša R, Stružinská I et. al.

Jan 29th, 2023 - Clear cell (hemangioblastoma-like) stromal tumor of the lung (CCSTL) is a rare pulmonary neoplasm. Recently, 9 cases of CCSTL harboring the YAP1-TFE3 gene fusion have been described, and it has been suggested that this aberration could be a characteristic feature of this tumor. We here report another case of CCSTL in a 57-year-old male, which presented as a solitary lung nodule 45 mm in the gre...

Biomembrane-Based Nanostructure- and Microstructure-Loaded Hydrogels for Promoting Chro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871051
International Journal of Nanomedicine; Liu WS, Liu Y et. al.

Jan 28th, 2023 - Wound healing is a complex and dynamic process, and metabolic disturbances in the microenvironment of chronic wounds and the severe symptoms they cause remain major challenges to be addressed. The inherent properties of hydrogels make them promising wound dressings. In addition, biomembrane-based nanostructures and microstructures (such as liposomes, exosomes, membrane-coated nanostructures, ba...

Thermo-neutrophilic cellulases and chitinases characterized from a novel putative antif...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882894
PloS One; Malik MS, Rehman A et. al.

Jan 28th, 2023 - Cellulose and chitin are the most abundant naturally occurring biopolymers synthesized in plants and animals and are used for synthesis of different organic compounds and acids in the industry. Therefore, cellulases and chitinases are important for their multiple uses in industry and biotechnology. Moreover, chitinases have a role in the biological control of phytopathogens. A bacterial strain ...

In vitro and Ex vivo Assessments of the Compatibility of Fibrin Sealant with Antimicrob...
https://doi.org/10.1089/sur.2022.315
Surgical Infections; Strickland AD, Lang C et. al.

Jan 28th, 2023 - Background: Fibrin sealants are used as antimicrobial-releasing carriers for preventing surgical site infections; however, it is important to determine the release kinetics and antimicrobial effects of drugs added to fibrin sealants and the effects of drugs on clot/clotting properties. Materials and Methods: The antimicrobial and antibiofilm activity of cefazolin, colistin, gentamicin, oxacilli...

The antioxidant glutathione.
https://doi.org/10.1016/bs.vh.2022.09.002
Vitamins and Hormones; Averill-Bates DA

Jan 28th, 2023 - Reduced glutathione (GSH) is an essential non-enzymatic antioxidant in mammalian cells. GSH can act directly as an antioxidant to protect cells against free radicals and pro-oxidants, and as a cofactor for antioxidant and detoxification enzymes such as glutathione peroxidases, glutathione S-transferases, and glyoxalases. Glutathione peroxidases detoxify peroxides by a reaction that is coupled t...

Local conditions matter: Minimal and variable effects of soil disturbance on microbial ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882891
PloS One; Steiner M, Pingel M et. al.

Jan 28th, 2023 - Soil tillage or herbicide applications are commonly used in agriculture for weed control. These measures may also represent a disturbance for soil microbial communities and their functions. However, the generality of response patterns of microbial communities and functions to disturbance have rarely been studied at large geographical scales. We investigated how a soil disturbance gradient (low,...

Protein l-isoAspartyl Methyltransferase (PIMT) and antioxidants in plants.
https://doi.org/10.1016/bs.vh.2022.10.005
Vitamins and Hormones; Ghosh S, Majee M

Jan 28th, 2023 - All life forms, including plants, accumulate reactive oxygen species (ROS) as a byproduct of metabolism; however, environmental stresses, including abiotic stresses and pathogen attacks, cause enhanced accumulation of ROS in plants. The increased accumulation of ROS often causes oxidative damage to cells. Organisms are able to maintain levels of ROS below permissible limits by several mechanism...