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About 826,610 results

Biosynthesis of vanillin by different microorganisms: a review.
https://doi.org/10.1007/s11274-022-03228-1 10.1007/s13205-017-0998-9 10.1016/j.nbt.2011.06.009 10.1007/s12010-011-9397-6 10.3923/ijp.2011.144.148 10.1186/1475-2859-9-84 10.1371/journal.pone.0164955 10.1038/srep20400 10.1016/j.ymben.2020.07.006 10.1016/j.jbiotec.2011.08.014 10.1186/1754-6834-1-3 10.1128/AEM.00802-16 10.1016/S1389-1723(03)90146-0 10.1007/s00253-013-5303-1 10.1007/s00253-015-7197-6 10.1128/AEM.02681-08 10.1007/s00253-006-0735-5 10.3389/fmicb.2016.01059 10.1016/j.jbiotec.2017.04.024 10.1007/s00284-006-0627-z 10.1007/s12010-012-0066-1 10.1007/s00253-014-5950-x 10.1016/j.btre.2014.09.002 10.1021/acssynbio.9b00071 10.1021/ja506664a 10.1186/s12934-016-0459-x 10.1002/bit.22040 10.1021/ja9817747 10.1016/j.procbio.2008.06.006 10.1111/1751-7915.13643 10.1021/jf803366f 10.3389/fbioe.2019.00279 10.1007/s00449-013-1060-x 10.1007/s10295-013-1255-9 10.1016/j.jbiosc.2014.02.025 10.1038/srep13670 10.1128/AEM.69.11.6569-6576.2003 10.1128/mSystems.00163-19 10.1016/j.nbt.2017.07.012 10.1007/s00253-005-0302-5 10.1007/s002530100687 10.1002/1097-0010(200002)80:3<289::aid-jsfa543>3.0.co;2-2 10.1080/14786419.2020.1849194 10.1271/bbb.120375 10.1007/s10295-014-1515-3 10.1016/s0168-1656(99)00199-6 10.1021/jf904141u 10.1007/s00449-020-02482-7 10.1007/s11274-015-1876-4 10.1360/crad20050909 10.1186/s12896-016-0264-y 10.3389/fmicb.2017.00367 10.1007/s00253-006-0569-1 10.1007/s10529-007-9602-4 10.1007/s10529-005-3561-4 10.1021/bp070153r 10.1002/jsfa.5962
World Journal of Microbiology & Biotechnology; Ma Q, Liu L et. al.

Jan 13th, 2022 - Vanillin is a popular flavoring agent widely used around the world. Vanillin is generated by natural extraction, chemical synthesis, or tissue culture technology, but these production methods no longer meet the increasing worldwide demand for vanillin. Accordingly, a biotechnological approach may provide an effective replacement route to obtaining vanillin. Processes for environmentally friendl...

Long-read transcriptome sequencing provides insight into lignan biosynthesis during fru...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742460
BMC Genomics; Hong CP, Kim CK et. al.

Jan 9th, 2022 - Schisandra chinensis, an ancient member of the most basal angiosperm lineage which is known as the ANITA, is a fruit-bearing vine with the pharmacological effects of a multidrug system, such as antioxidant, anti-inflammatory, cardioprotective, neuroprotective, anti-osteoporosis effects. Its major bioactive compound is represented by lignans such as schisandrin. Molecular characterization of lig...

Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SA...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690919
Theranostics Huang KA, Zhou D et. al.

Jan 7th, 2022 - Background: Administration of potent anti-receptor-binding domain (RBD) monoclonal antibodies has been shown to curtail viral shedding and reduce hospitalization in patients with SARS-CoV-2 infection. However, the structure-function analysis of potent human anti-RBD monoclonal antibodies and its links to the formulation of antibody cocktails remains largely elusive. Methods: Previously, we isol...

Spectral image contrast-based flow digital nanoplasmon-metry for ultrasensitive antibod...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724237
Journal of Nanobiotechnology; Wang SH, Kuo CW et. al.

Jan 6th, 2022 - Gold nanoparticles (AuNPs) have been widely used in local surface plasmon resonance (LSPR) immunoassays for biomolecule sensing, which is primarily based on two conventional methods: absorption spectra analysis and colorimetry. The low figure of merit (FoM) of the LSPR and high-concentration AuNP requirement restrict their limit of detection (LOD), which is approximately ng to μg mL-1 in antibo...

The Effect of Green Coffee Bean Extract on Cardiovascular Risk Factors: A Systematic Re...
https://doi.org/10.1007/978-3-030-73234-9_21
Advances in Experimental Medicine and Biology; Pourmasoumi M, Hadi A et. al.

Jan 5th, 2022 - Cardiovascular disease remains the primary cause of noncommunicable disease- related death. The present systematic review and meta-analysis was performed to assess the possible benefit of the green coffee bean extract on cardio-metabolic markers. PubMed, Scopus, Web of Science, and Cochrane Library were systematically searched to identify clinical trials that examined the effect of green coffee...

The Effects of Ivy (Hedera helix) on Respiratory Problems and Cough in Humans: A Review.
https://doi.org/10.1007/978-3-030-73234-9_23 10.1078/094471103321659979 10.1002/ddr.21292 10.1002/ptr.4671 10.15406/jlprr.2014.01.00016 10.1016/j.phymed.2011.06.014 10.1159/000057269 10.36740/WLek202004108 10.1016/j.phymed.2014.05.006 10.1002/pauz.200890115 10.1016/j.phymed.2010.11.009
Advances in Experimental Medicine and Biology; Baharara H, Moghadam AT et. al.

Jan 5th, 2022 - Hedera helix (ivy) belongs to the genus Hedera of the Araliaceae family. The leaf of this plant has several active ingredients with medicinal uses. The active constituents of H. helix include monodesmoside α-hederin, hederacoside B, hederacoside C, and hederacoside D.H. helix leave have been used for the treatment of cough and respiratory problems, and now, other uses have emerged. As a medicin...

A Review on the Phytochemistry, Pharmacology, and Therapeutic Effects of Rheum ribes.
https://doi.org/10.1007/978-3-030-73234-9_30
Advances in Experimental Medicine and Biology; Keshavarzi Z, Shakeri F et. al.

Jan 5th, 2022 - Herbal medications are typically used for the treatment of diverse diseases without significant adverse effects. The Rheum ribes (R. ribes), commonly called rhubarb, is a hardy perennial herb and is consumed all over the world. There is growing evidence of the therapeutic benefits of R. ribes. Extensive in vitro and in vivo investigations have shown that R. ribes reveals beneficial properties v...

Genetic identification of bat species for pathogen surveillance across France.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726466
PloS One; Arnaout Y, Djelouadji Z et. al.

Jan 5th, 2022 - With more than 1400 chiropteran species identified to date, bats comprise one-fifth of all mammalian species worldwide. Many studies have associated viral zoonoses with 45 different species of bats in the EU, which cluster within 5 families of bats. For example, the Serotine bats are infected by European Bat 1 Lyssavirus throughout Europe while Myotis bats are shown infected by coronavirus, her...

Assessing the potential of the two-peptide lantibiotic lichenicidin as a new generation...
https://doi.org/10.1007/s11274-021-03196-y 10.1371/journal.pone.0083037 10.1039/c2np20085f 10.1128/AAC.01813-15 10.1021/jacs.7b04728 10.1021/np500424y 10.1002/bit.27130 10.1038/srep31749 10.1371/journal.pone.0187756 10.1128/AEM.00730-09 10.1002/mbo3.606 10.1016/j.chembiol.2010.11.010 10.1128/AEM.00270-11 10.1016/j.resmic.2014.07.006 10.1038/srep21385 10.1046/j.1462-5822.2003.00310.x 10.1111/j.1365-2958.2006.05398.x 10.1371/journal.pone.0006788 10.1016/j.ijmm.2013.09.003 10.1111/j.1365-2958.2008.06279.x 10.3389/fmicb.2015.01363 10.1177/002215549804600804 10.1101/303636 10.1016/j.mib.2018.02.010 10.1042/BST20120190 10.1016/J.IJANTIMICAG.2019.03.020 10.1002/FFT2.44 10.3389/fmicb.2018.00415 10.1146/annurev-biochem-060110-113521 10.1007/s00253-015-6557-6 10.1016/S0140-6736(47)90004-4 10.1002/anie.200905773 10.1023/B:BILE.0000012888.72489.3f 10.1002/anie.201500927 10.1128/AAC.49.7.2606-2611.2005 10.1002/anie.201106154 10.1021/cb900194x 10.1021/ja206281k 10.1186/s12934-016-0502-y 10.1002/cbf.3135 10.1590/S1413-86702008000200003 10.1074/jbc.RA117.000125 10.3390/md10102280 10.1530/rep.1.00028 10.1038/s41598-018-26238-2 10.1021/acs.chemrev.6b00591 10.1021/bi100871b 10.1038/ja.2011.5 10.1517/17425255.2011.573478 10.3390/toxins5050895 10.1111/j.1365-2958.2006.05223.x 10.1146/annurev.micro.61.080706.093501 10.1128/AEM.01851-15 10.3389/FMICB.2016.01115
World Journal of Microbiology & Biotechnology; Barbosa JC, Silva ÍC et. al.

Jan 4th, 2022 - Lantibiotics are a promising class of natural antimicrobial peptides. Lichenicidin is a two-peptide lantibiotic in which two mature peptides act synergistically to exhibit full bioactivity. Considering the two-peptide lantibiotics described so far, only cytolysin has been deeply characterized in terms of toxicity towards eukaryotic cells and it was found to be hemolytic and cytotoxic. This work...

Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody cli...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719770
PloS One; Issafras H, Fan S et. al.

Jan 1st, 2022 - Cancer immunotherapies, such as checkpoint blockade of programmed cell death protein-1 (PD-1), represents a breakthrough in cancer treatment, resulting in unprecedented results in terms of overall and progression-free survival. Discovery and development of novel anti PD-1 inhibitors remains a field of intense investigation, where novel monoclonal antibodies (mAbs) and novel antibody formats (e....

Prostaglandin analog effects on cerebrospinal fluid reabsorption via nasal mucosa.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719688
PloS One; Pedler MG, Petrash JM et. al.

Jan 1st, 2022 - Cerebrospinal fluid (CSF) outflow has been demonstrated along nasal lymphatics via olfactory nerve projections; flow may be increased by stimulating lymphatic contractility using agents such as noradrenaline and the thromboxane A2 analog U46619. Lymphatics elsewhere in the body show increased contractility upon exposure to the prostaglandin F2alpha analog isoprostane-8-epi-prostaglandin. We inv...

Dipeptidyl Peptidase-4 from Cancer-associated Fibroblasts Stimulates the Proliferation ...
https://doi.org/10.21873/anticanres.15508
Anticancer Research; Kushiyama S, Yashiro M et. al.

Jan 1st, 2022 - Cancer-associated fibroblasts (CAFs) may promote the malignancy of human scirrhous gastric cancer (SGC) cells. We conducted the present study to identify novel growth factors from CAFs. OCUM-12 and 2 CAF cell lines were used. The proliferation of cancer cells was determined by the number of cancer cells or the MTT assay. The growth factor(s) were purified and characterized by the gel filtration...

Effectiveness and safety of oral lactococci-based vaccine encoding triple common allerg...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719749
PloS One; Lee MF, Chiang CH et. al.

Jan 1st, 2022 - Allergic airway disease is the most common chronic airway inflammatory disorder in developed countries. House dust mite, cockroach, and mold are the leading allergens in most tropical and subtropical countries, including Taiwan. As allergen avoidance is difficult for patients allergic to these perennial indoor allergens, allergen-specific immunotherapy (ASIT) is the only available allergen-spec...

Mangrove crab intestine and habitat sediment microbiomes cooperatively work on carbon a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719709
PloS One; Tongununui P, Kuriya Y et. al.

Jan 1st, 2022 - Mangrove ecosystems, where litter and organic components are degraded and converted into detrital materials, support rich coastal fisheries resources. Sesarmid (Grapsidae) crabs, which feed on mangrove litter, play a crucial role in material flow in carbon-rich and nitrogen-limited mangrove ecosystems; however, the process of assimilation and conversion into detritus has not been well studied. ...

Tweezepy: A Python package for calibrating forces in single-molecule video-tracking exp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719779
PloS One; Morgan IL, Saleh OA

Jan 1st, 2022 - Single-molecule force spectroscopy (SMFS) instruments (e.g., magnetic and optical tweezers) often use video tracking to measure the three-dimensional position of micron-scale beads under an applied force. The force in these experiments is calibrated by comparing the bead trajectory to a thermal motion-based model with the drag coefficient, γ, and trap spring constant, κ, as parameters. Estimati...

MHC class I antigen cross-presentation mediated by PapMV nanoparticles in human antigen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719699
PloS One; Possamaï D, Hanafi LA et. al.

Jan 1st, 2022 - Nanoparticles made of the coat protein of papaya mosaic virus (PapMV) and a single-strand RNA were previously shown to be an efficient antigen presentation system for the trigger of cellular immunity. Engineering of PapMV nano with a cytotoxic T lymphocyte epitope was previously shown activating specific T lymphocytes through a proteasome-independent major histocompatibility complex class I (MH...

Growth modulation and metabolic responses of Ganoderma boninense to salicylic acid stress.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719765
PloS One; Ong CE, Ahmad R et. al.

Jan 1st, 2022 - Various phenolic compounds have been screened against Ganoderma boninense, the fungal pathogen causing basal stem rot in oil palms. In this study, we focused on the effects of salicylic acid (SA) on the growth of three G. boninense isolates with different levels of aggressiveness. In addition, study on untargeted metabolite profiling was conducted to investigate the metabolomic responses of G. ...

Transcriptomic profiling of adjuvant colorectal cancer identifies three key prognostic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719661
PloS One; Daemen A, Udyavar AR et. al.

Jan 1st, 2022 - Colorectal cancer (CRC) is a leading cause of cancer-related deaths, with a 5% 5-year survival rate for metastatic disease, yet with limited therapeutic advancements due to insufficient understanding of and inability to accurately capture high-risk CRC patients who are most likely to recur. We aimed to improve high-risk classification by identifying biological pathways associated with outcome i...

The role of Leishmania GP63 in the modulation of innate inflammatory response to Leishm...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719666
PloS One; Chan A, Ayala JM et. al.

Jan 1st, 2022 - Leishmaniasis is a disease caused by the protozoan parasite Leishmania and is known to affect millions of individuals worldwide. In recent years, we have established the critical role played by Leishmania zinc-metalloprotease GP63 in the modulation of host macrophage signalling and functions, favouring its survival and progression within its host. Leishmania major lacking GP63 was reported to c...

Effects of osmolality and solutes on the morphology of red blood cells according to thr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719701
PloS One; Son M, Lee YS et. al.

Jan 1st, 2022 - Phosphate-buffered saline (PBS) and Alsever's solution (AS) are frequently used as media in blood-related studies, while 0.9% normal saline (NS) is frequently used in transfusion medicine. Despite the frequent use, the effects of these solutions on the shape and volume of red blood cells (RBCs) have not been reported. We collected blood samples from five healthy adults and used three-dimensiona...