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About 281,770 results

Genetic identification of bat species for pathogen surveillance across France.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726466
PloS One; Arnaout Y, Djelouadji Z et. al.

Jan 5th, 2022 - With more than 1400 chiropteran species identified to date, bats comprise one-fifth of all mammalian species worldwide. Many studies have associated viral zoonoses with 45 different species of bats in the EU, which cluster within 5 families of bats. For example, the Serotine bats are infected by European Bat 1 Lyssavirus throughout Europe while Myotis bats are shown infected by coronavirus, her...

Visual classification of three computed tomography lung patterns to predict prognosis o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721943
BMC Pulmonary Medicine; Yamada D, Ohde S et. al.

Jan 5th, 2022 - Quantitative evaluation of radiographic images has been developed and suggested for the diagnosis of coronavirus disease 2019 (COVID-19). However, there are limited opportunities to use these image-based diagnostic indices in clinical practice. Our aim in this study was to evaluate the utility of a novel visually-based classification of pulmonary findings from computed tomography (CT) images of...

Novel loss functions for ensemble-based medical image classification.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718001
PloS One; Rajaraman S, Zamzmi G et. al.

Dec 31st, 2021 - Medical images commonly exhibit multiple abnormalities. Predicting them requires multi-class classifiers whose training and desired reliable performance can be affected by a combination of factors, such as, dataset size, data source, distribution, and the loss function used to train deep neural networks. Currently, the cross-entropy loss remains the de-facto loss function for training deep lear...

Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726722
Gut Microbes; Sencio V, Machelart A et. al.

Dec 30th, 2021 - Mounting evidence suggests that the gut-to-lung axis is critical during respiratory viral infections. We herein hypothesized that disruption of gut homeostasis during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may associate with early disease outcomes. To address this question, we took advantage of the Syrian hamster model. Our data confirmed that this model recapitu...

Circulating dengue virus serotypes and vertical transmission in Aedes larvae during out...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705164
Parasites & Vectors; Wijesinghe C, Gunatilake J et. al.

Dec 25th, 2021 - Spatial and temporal changes in the dengue incidence are associated with multiple factors, such as climate, immunity among a population against dengue viruses (DENV), circulating DENV serotypes and vertical transmission (VT) of DENV in an area at a given time. The level of VT in a specific location has epidemiological implications in terms of viral maintenance in vectors. Identification of the ...

Molecular subtyping for source tracking of Escherichia coli using core genome multilocu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699670
PloS One; Nakamura A, Takahashi H et. al.

Dec 24th, 2021 - When harmful bacteria are detected in the final product at a food manufacturing plant, it is necessary to identify and eliminate the source of contamination so that it does not occur again. In the current study, the source of contamination was tracked using core genome multilocus sequence typing (cgMLST) analysis in cases where Escherichia coli was detected in the final product at a food manufa...

Expert-enhanced machine learning for cardiac arrhythmia classification.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699667
PloS One; Sager S, Bernhardt F et. al.

Dec 24th, 2021 - We propose a new method for the classification task of distinguishing atrial fibrillation (AFib) from regular atrial tachycardias including atrial flutter (AFlu) based on a surface electrocardiogram (ECG). Recently, many approaches for an automatic classification of cardiac arrhythmia were proposed and to our knowledge none of them can distinguish between these two. We discuss reasons why deep ...

Supervised and unsupervised learning to classify scoliosis and healthy subjects based o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699618
PloS One; Colombo T, Mangone M et. al.

Dec 24th, 2021 - The aim of our study was to classify scoliosis compared to to healthy patients using non-invasive surface acquisition via Video-raster-stereography, without prior knowledge of radiographic data. Data acquisitions were made using Rasterstereography; unsupervised learning was adopted for clustering and supervised learning was used for prediction model Support Vector Machine and Deep Network archi...

The genomes of 204 Vitis vinifera accessions reveal the origin of European wine grapes.
https://doi.org/10.1038/s41467-021-27487-y
Nature Communications; Magris G, Jurman I et. al.

Dec 23rd, 2021 - In order to elucidate the still controversial processes that originated European wine grapes from its wild progenitor, here we analyse 204 genomes of Vitis vinifera and show that all analyses support a single domestication event that occurred in Western Asia and was followed by numerous and pervasive introgressions from European wild populations. This admixture generated the so-called internati...

NGS read classification using AI.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694450
PloS One; Voigt B, Fischer O et. al.

Dec 23rd, 2021 - Clinical metagenomics is a powerful diagnostic tool, as it offers an open view into all DNA in a patient's sample. This allows the detection of pathogens that would slip through the cracks of classical specific assays. However, due to this unspecific nature of metagenomic sequencing, a huge amount of unspecific data is generated during the sequencing itself and the diagnosis only takes place at...

In vitro characterization of Haemonchus contortus trehalose-6-phosphate phosphatase and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685816
Parasites & Vectors; Wen Z, Xie X et. al.

Dec 22nd, 2021 - Trehalose-6-phosphate phosphatase (TPP6) is a key enzyme in the trehalose biosynthesis pathway. The accumulation of TPP6 inside the body is harmful to the pathogen, but almost nothing is currently known about the function of TPP6 from Haemonchus contortus (CRE-GOB-1). The H. contortus CRE-GOB-1 (HcGOB) gene was cloned and recombinant protein of GOB (rHcGOB) was expressed; transcription of the H...

Divergence together with microbes: A comparative study of the associated microbiomes in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691637
PloS One; Maltseva AL, Varfolomeeva MA et. al.

Dec 22nd, 2021 - Any multicellular organism during its life is involved in relatively stable interactions with microorganisms. The organism and its microbiome make up a holobiont, possessing a unique set of characteristics and evolving as a whole system. This study aimed to evaluate the degree of the conservativeness of microbiomes associated with intertidal gastropods. We studied the composition and the geogra...

Generation and characterization of genetically and antigenically diverse infectious clo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745371
Emerging Microbes & Infections; Tamura T, Zhang J et. al.

Dec 22nd, 2021 - Dengue is caused by four genetically distinct viral serotypes, dengue virus (DENV) 1-4. Following transmission by Aedes mosquitoes, DENV can cause a broad spectrum of clinically apparent disease ranging from febrile illness to dengue hemorrhagic fever and dengue shock syndrome. Progress in the understanding of different dengue serotypes and their impacts on specific host-virus interactions has ...

Morphological and molecular differentiation between Culicoides oxystoma and Culicoides ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684274
Parasites & Vectors; Slama D, Baraket R et. al.

Dec 20th, 2021 - Culicoides kingi and Culicoides oxystoma belong to the Schultzei group of biting midges. These two species are vectors of disease in livestock of economic importance. As described in the literature, morphological identification for discrimination between them is still unclear. However, species-specific identification is necessary to solve taxonomic challenges between species and to understand t...

Tandem mass tag (TMT)-based proteomic analysis of Cryptosporidium andersoni oocysts bef...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683822
Parasites & Vectors; Li DF, Cui ZH et. al.

Dec 20th, 2021 - Cryptosporidium andersoni initiates infection by releasing sporozoites from oocysts through excystation. However, the proteins involved in excystation are unknown. Determining the proteins that participate in the excystation of C. andersoni oocysts will increase our understanding of the excystation process. Cryptosporidium andersoni oocysts were collected and purified from the feces of naturall...

KRSA: An R package and R Shiny web application for an end-to-end upstream kinase analys...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682895
PloS One; DePasquale EAK, Alganem K et. al.

Dec 18th, 2021 - Phosphorylation by serine-threonine and tyrosine kinases is critical for determining protein function. Array-based platforms for measuring reporter peptide signal levels allow for differential phosphorylation analysis between conditions for distinct active kinases. Peptide array technologies like the PamStation12 from PamGene allow for generating high-throughput, multi-dimensional, and complex ...

The pink salmon genome: Uncovering the genomic consequences of a two-year life cycle.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682878
PloS One; Christensen KA, Rondeau EB et. al.

Dec 18th, 2021 - Pink salmon (Oncorhynchus gorbuscha) adults are the smallest of the five Pacific salmon native to the western Pacific Ocean. Pink salmon are also the most abundant of these species and account for a large proportion of the commercial value of the salmon fishery worldwide. A two-year life history of pink salmon generates temporally isolated populations that spawn either in even-years or odd-year...

Omicron blindspots: why it's hard to track coronavirus variants.
https://doi.org/10.1038/d41586-021-03698-7
Nature Maxmen A

Dec 18th, 2021 - Omicron blindspots: why it's hard to track coronavirus variants.|2021|Maxmen A,|epidemiology,virology,genetics,classification,genetics,isolation & purification,

Shotgun sequence-based metataxonomic and predictive functional profiles of Pe poke, a n...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682898
PloS One; Tamang JP, Kharnaior P et. al.

Dec 18th, 2021 - Pe poke is a naturally fermented sticky soybean food of Myanmar. The present study was aimed to profile the whole microbial community structure and their predictive gene functionality of pe poke samples prepared in different fermentation periods viz. 3 day (3ds), 4 days (4ds), 5 days (5ds) and sun-dried sample (Sds). The pH of samples was 7.6 to 8.7, microbial load was 2.1-3.9 x 108 cfu/g with ...

Analysis of migration of pathogenic drug-resistant bacteria to soils and groundwater af...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675741
PloS One; Stańczyk-Mazanek E, Stępniak L

Dec 17th, 2021 - The paper discusses the analysis of the effect of using sewage sludge for fertilization on the level of soil and groundwater contamination with drug-resistant bacteria. Other sanitary contaminants in these environments were also analysed. Composted sewage sludge was introduced into the sandy soil over a period of 6 months. The examinations were conducted under conditions of a lysimetric experim...