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About 406,700 results

Cells of the human intestinal tract mapped across space and time.
https://doi.org/10.1038/s41586-021-03852-1 10.1016/j.devcel.2020.11.010 10.1016/j.stem.2020.11.008 10.1016/j.cell.2020.12.016 10.1038/s41590-020-0602-z 10.1016/j.cell.2018.08.067 10.1016/j.cell.2019.06.029 10.1126/sciimmunol.abb4432 10.1038/s41591-020-1003-4 10.1016/j.cell.2019.10.027 10.1016/j.cell.2019.08.008 10.1371/journal.pone.0079693 10.1038/s41586-019-0992-y 10.1126/science.abc1669 10.1016/j.cell.2020.04.036 10.1152/ajpregu.00638.2003 10.2337/db18-0883 10.1016/j.cell.2018.12.029 10.1210/endrev/bnaa018 10.1111/sji.12305 10.1038/s41593-020-00736-x 10.1053/j.gastro.2020.09.032 10.1053/j.gastro.2017.10.005 10.1053/j.gastro.2018.09.012 10.1038/s41598-017-14835-6 10.1016/j.ydbio.2016.06.042 10.1016/j.smim.2008.02.003 10.1038/s41590-020-0635-3 10.1038/s41586-019-1652-y 10.1016/j.immuni.2019.06.027 10.1016/j.immuni.2018.04.006 10.4049/jimmunol.1501162 10.1111/j.1365-2036.2011.04605.x 10.1038/ng.3760 10.1136/gutjnl-2012-303956 10.1007/s10875-020-00794-7 10.1293/tox.2016-0075 10.1038/s41590-018-0294-9 10.1016/j.immuni.2018.12.010 10.1038/ni.1668 10.1016/j.celrep.2017.01.063 10.1016/j.immuni.2013.11.006 10.4049/jimmunol.1501191 10.1016/j.immuni.2016.09.001 10.1038/s41590-019-0505-z 10.1126/science.1260419 10.1136/gutjnl-2017-314817 10.1093/gigascience/giaa151 10.1126/science.aad0501 10.1093/nar/gkaa1204 10.1126/science.1161431 10.1038/s41586-019-1154-y 10.1016/j.cell.2020.08.003 10.1016/j.cmet.2013.06.008 10.1016/j.scr.2016.04.011 10.1016/j.celrep.2017.05.019 10.1371/journal.pone.0176031 10.1158/2326-6066.CIR-19-0796 10.1371/journal.pone.0025391 10.1084/jem.20050879 10.4049/jimmunol.1900592 10.1038/s41422-020-00445-x 10.1016/j.cell.2017.02.021 10.1523/JNEUROSCI.0361-11.2011 10.1038/s41419-019-1540-2 10.1016/j.immuni.2018.12.009 10.1126/science.aau0964 10.1126/science.aam7511 10.1038/nmeth.3800 10.1038/nmeth.3545 10.1093/nar/gkv007 10.1038/s41587-020-0591-3 10.1186/s13059-019-1663-x 10.1126/sciimmunol.abe6291 10.1093/nar/gkt382 10.1093/bioinformatics/btu138 10.1093/bioinformatics/btv359 10.1038/s41596-020-0292-x 10.1038/s41586-018-0698-6 10.1371/journal.pgen.1000214 10.1016/j.ajhg.2014.03.004 10.1086/519024 10.1038/s41588-018-0278-6
Nature Elmentaite R, Kumasaka N et. al.

Sep 10th, 2021 - The cellular landscape of the human intestinal tract is dynamic throughout life, developing in utero and changing in response to functional requirements and environmental exposures. Here, to comprehensively map cell lineages, we use single-cell RNA sequencing and antigen receptor analysis of almost half a million cells from up to 5 anatomical regions in the developing and up to 11 distinct anat...

Transient receptor potential ankyrin 1 mediates cisplatin-induced apoptosis in renal tu...
https://doi.org/10.21037/apm-21-1867
Annals of Palliative Medicine; Meng X, Zhang Y et. al.

Sep 8th, 2021 - Cisplatin has been a vital drug used for tumor treatment because of its excellent effect on numerous malignant solid cancers. Nonetheless, its nephrotoxicity is non-negligible in clinical practice. This study aims to provide a new understanding of the molecular mechanism of transient receptor potential ankyrin 1 (TRPA1) in cisplatin-induced renal apoptosis. We evaluated the effect on apoptosis,...

Cancer Associated Fibroblasts Derived from Pancreatic Adenocarcinoma and Their Role in ...
https://doi.org/10.21873/anticanres.15227
Anticancer Research; VON Hoerschelmann E, Neumann CCM et. al.

Sep 4th, 2021 - Pancreatic ductal adenocarcinoma (PDAC) shows poor survival and early systemic dissemination. Cancer associated fibroblasts (CAFs) enhance migration and invasion of cancer cells. We aimed to investigate the role of CAFs in cell migration and their underlying paracrine effects. Using Transwell® migration assays, PDAC cells (PANC-1) and three distinct types of fibroblasts were analyzed: CAFs, gen...

Telmisartan Facilitates the Anticancer Effects of CARP-1 Functional Mimetic and Sorafen...
https://doi.org/10.21873/anticanres.15226
Anticancer Research; Surapaneni SK, Nottingham E et. al.

Sep 4th, 2021 - Tyrosine kinase inhibitors (TKIs) are used for the treatment of both wild type and mutant non-small cell lung cancer (NSCLC); however, acquired resistance is a major clinical challenge. Herein, we aimed to investigate the effects of telmisartan (Tel), CFM 4.16 and sorafenib combination in rociletinib resistant NSCLC tumors. 3D spheroid cultures and western blotting were used for evaluating cyto...

Soluble Factors Involved in Cancer Cell-Macrophage Interaction Promote Breast Cancer Gr...
https://doi.org/10.21873/anticanres.15229
Anticancer Research; Yonemitsu K, Miyasato Y et. al.

Sep 4th, 2021 - Recent studies have indicated the clinical significance of tumor-associated macrophages (TAMs) in breast cancer; however, the detailed mechanisms of cell-cell interactions between TAMs and cancer cells remain unclear. In vitro cell culture studies using human monocyte-derived macrophages and breast cancer cell lines were performed to test which cytokines would be involved in cell-cell interacti...

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glu...
https://doi.org/10.1038/s41467-021-25380-2 10.1016/S0140-6736(14)60460-8 10.1242/dmm.026609 10.3389/fnins.2020.00691 10.1016/S0092-8674(00)80949-6 10.1073/pnas.95.1.322 10.1385/NCC:3:3:230 10.1002/ana.1130 10.1016/S0896-6273(01)00293-8 10.1523/JNEUROSCI.0073-14.2014 10.1016/j.cmet.2008.10.010 10.1016/j.neuropharm.2014.06.015 10.1038/nature06310 10.1507/endocrj.EJ12-0030 10.2337/db14-0695 10.1016/j.isci.2019.09.003 10.1002/cne.1190 10.1016/S0167-0115(01)00357-3 10.1016/S0306-4522(01)00033-1 10.1006/hbeh.2000.1584 10.1016/j.neuron.2015.10.007 10.1016/j.neuropharm.2011.04.008 10.1098/rstb.2012.0039 10.1016/j.ejphar.2010.12.024 10.1016/j.pbb.2010.09.003 10.1016/j.neuron.2014.02.010 10.3389/fnins.2013.00036 10.1016/j.cmet.2015.04.008 10.1523/JNEUROSCI.3909-11.2011 10.1038/nn.2467 10.1152/jn.01388.2007 10.1523/JNEUROSCI.22-21-09453.2002 10.1523/JNEUROSCI.22-20-08850.2002 10.1146/annurev.med.60.042307.110802 10.1523/JNEUROSCI.3258-04.2005 10.1016/S0028-3908(00)00178-7 10.1007/400_2007_047 10.1038/ijo.2013.52 10.1038/ni.3746 10.1016/j.cmet.2018.03.005 10.1016/j.cell.2015.02.022 10.1126/science.1219855 10.1016/j.molcel.2016.02.022 10.1016/j.cmet.2011.08.010 10.1016/j.cmet.2009.09.013 10.1073/pnas.0810793106 10.1016/S0091-3022(03)00028-1 10.1007/s00213-010-2089-z 10.1016/j.cell.2018.07.043 10.1523/JNEUROSCI.5196-09.2010 10.1016/j.cell.2017.06.045 10.1016/j.neuron.2014.07.002 10.1016/j.celrep.2014.06.042 10.1016/j.pnpbp.2005.11.025 10.1016/j.celrep.2015.10.061 10.1038/nature02033 10.1038/nn.3078 10.1038/75973 10.1006/geno.2000.6451 10.1016/j.cell.2014.04.043 10.1038/nmeth.4197 10.1186/s13059-014-0550-8 10.1089/omi.2011.0118 10.1038/ncb2211 10.1016/j.cmet.2007.05.004 10.1042/bj2280103 10.1016/j.bpj.2008.11.034 10.1016/j.jneumeth.2006.06.006 10.1038/nn.3449 10.1016/j.cmet.2011.03.021 10.1016/0006-8993(90)90380-T 10.2170/jjphysiol.44.433 10.1085/jgp.92.2.145 10.1038/319150a0 10.1016/0165-0270(91)90017-T 10.1016/j.neuron.2005.12.021 10.1152/jn.00660.2007
Nature Communications; Xiao X, Yeghiazaryan G et. al.

Sep 4th, 2021 - The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here we show orexin receptor type 1 and 2 are predominantly expressed in dorsal raphe nucleus-dorsal and -ventral, respectively. Serotonergic neurons in ventral median raphe nucleus and raphe pallidus selectively express orexin receptor type 1. Inactivation of orexin receptor type 1 in serotonin...

Immunometabolic signatures predict risk of progression to sepsis in COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405033
PloS One; Herrera-Van Oostdam AS, Castañeda-Delgado JE et. al.

Aug 31st, 2021 - Viral sepsis has been proposed as an accurate term to describe all multisystemic dysregulations and clinical findings in severe and critically ill COVID-19 patients. The adoption of this term may help the implementation of more accurate strategies of early diagnosis, prognosis, and in-hospital treatment. We accurately quantified 110 metabolites using targeted metabolomics, and 13 cytokines/chem...

Sysmex UF-5000 Automatic Urine Sediment Analyzer Can Improve the Accuracy of Epithelial...
https://www.ncbi.nlm.nih.gov/pubmed/34452897
Annals of Clinical and Laboratory Science; Chen Y, Zhang Z et. al.

Aug 29th, 2021 - The aim of this study was to evaluate the consistency and accuracy of all the parameters of the urine samples detected by two automated urine sediment analyzers from Sysmex Corporation. Two automated analyzers and manual microscopy examined 1,059 urine samples. The sensitivity, specificity, positive predictive value, and negative predictive value were evaluated. The consistency of all the param...

Energy metabolism of cells in the macula flava of the newborn vocal fold from the aspec...
https://doi.org/10.1017/S0022215121001614
The Journal of Laryngology and Otology; Sato K, Chitose S et. al.

Aug 28th, 2021 - Cells in the vocal fold of maculae flavae are likely to be tissue stem cells. Energy metabolism of the cells in newborn maculae flavae was investigated from the aspect of mitochondrial microstructure. Five normal newborn vocal folds were investigated under transmission electron microscopy. Mitochondria consisted of a double membrane bounded body containing matrices and a system of cristae. Howe...

Modeling Human Cardiac Chambers with Organoids.
https://doi.org/10.1056/NEJMcibr2108627
The New England Journal of Medicine; Srivastava D

Aug 27th, 2021 - Modeling Human Cardiac Chambers with Organoids.|2021|Srivastava D,|growth & development,physiopathology,physiology,cytology,anatomy & histology,cytology,growth & development,

Engineered whole cut meat-like tissue by the assembly of cell fibers using tendon-gel i...
https://doi.org/10.1038/s41467-021-25236-9 10.3389/fnut.2020.00007 10.1111/1541-4337.12473 10.1016/j.tifs.2020.01.026 10.1038/s43016-020-0046-5 10.3389/fnut.2020.00010 10.1016/j.meatsci.2012.04.008 10.1038/s41598-018-28746-7 10.1016/j.tibtech.2020.02.012 10.1038/s43016-020-0112-z 10.1038/s41598-018-32163-1 10.1021/nn4063962 10.1038/nmat3606 10.1002/adfm.201800405 10.1016/j.biomaterials.2017.03.026 10.1002/adhm.201600483 10.1007/s13534-020-00171-8 10.1126/sciadv.1500655 10.1126/sciadv.1500758 10.1016/j.biomaterials.2019.03.036 10.1126/science.aav9051 10.1126/sciadv.aaw2459 10.4314/sokjvs.v15i4.11 10.1038/s41427-018-0014-9 10.1016/j.actbio.2018.11.048 10.2174/138920210791110960 10.2527/jas.2009-2579 10.1016/j.bbadis.2018.01.025 10.1186/s12986-017-0179-1 10.1016/0959-437X(95)80025-5 10.1016/j.mce.2009.08.015 10.1038/s41598-019-43624-6 10.1002/cbf.1488 10.1021/acsbiomaterials.8b01272 10.1016/j.biomaterials.2013.08.062 10.1016/j.actbio.2015.06.033 10.3389/fphys.2018.00483 10.1371/journal.pone.0202574 10.1038/s41467-017-02636-4 10.1182/blood.V99.8.2835 10.1002/aja.1002020109 10.1038/s41538-021-00090-7 10.1242/dev.114223 10.4238/2013.January.4.21 10.1016/j.bbrc.2016.11.067 10.1002/adbi.202070052 10.1016/j.bbrc.2009.01.174
Nature Communications; Kang DH, Louis F et. al.

Aug 26th, 2021 - With the current interest in cultured meat, mammalian cell-based meat has mostly been unstructured. There is thus still a high demand for artificial steak-like meat. We demonstrate in vitro construction of engineered steak-like tissue assembled of three types of bovine cell fibers (muscle, fat, and vessel). Because actual meat is an aligned assembly of the fibers connected to the tendon for the...

Insulin signaling establishes a developmental trajectory of adipose regulatory T cells.
https://doi.org/10.1038/s41590-021-01010-3
Nature Immunology; Li Y, Lu Y et. al.

Aug 26th, 2021 - Systematic characterizations of adipose regulatory T (Treg) cell subsets and their phenotypes remain uncommon. Using single-cell ATAC-sequencing and paired single-cell RNA and T cell receptor (TCR) sequencing to map mouse adipose Treg cells, we identified CD73hiST2lo and CD73loST2hi subsets with distinct clonal expansion patterns. Analysis of TCR-sharing data implied a state transition between ...

Immune cell compartmentalization for brain surveillance and protection.
https://doi.org/10.1038/s41590-021-00994-2
Nature Immunology; Croese T, Castellani G et. al.

Aug 26th, 2021 - For decades, it was commonly accepted that the brain is secluded from peripheral immune activity and is self-sufficient for its maintenance and repair. This simplistic perception was based on the presence of resident immune cells, the microglia, and barrier systems within the brain, and the assumption that the central nervous system (CNS) lacks lymphatic drainage. This view was revised with the...

Discrete tissue microenvironments instruct diversity in resident memory T cell function...
https://doi.org/10.1038/s41590-021-01004-1
Nature Immunology; Christo SN, Evrard M et. al.

Aug 25th, 2021 - Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the body. Although TRM cells in various organs rely on common transcriptional networks to establish tissue residency, location-specific factors adapt these cells to their tissue of lodgment. Here we analyze TRM cell heterogeneity between organs and find that the different environments in which these cells dif...

Prognostic role of NK cell percentages in bronchoalveolar lavage from patients with dif...
https://doi.org/10.1016/j.clim.2021.108827
Clinical Immunology (Orlando, Fla.); Bergantini L, d'Alessandro M et. al.

Aug 25th, 2021 - BAL cellularity and lymphocyte immunophenotyping offer insights into lung inflammatory status. Natural killer (NK) cells are efficient effector cells, producing pro-inflammatory cytokines. A better understanding of the biology of NK cells in BAL in the lungs is necessary to improve the pathogenesis of fibrotic ILD and develop prospective targeted treatments. Our aim was to analyse NK and NKT-li...

Selenium-GPX4 axis protects follicular helper T cells from ferroptosis.
https://doi.org/10.1038/s41590-021-00996-0
Nature Immunology; Yao Y, Chen Z et. al.

Aug 21st, 2021 - Follicular helper T (TFH) cells are a specialized subset of CD4+ T cells that essentially support germinal center responses where high-affinity and long-lived humoral immunity is generated. The regulation of TFH cell survival remains unclear. Here we report that TFH cells show intensified lipid peroxidation and altered mitochondrial morphology, resembling the features of ferroptosis, a form of ...

CD11b+ lung dendritic cells at different stages of maturation induce Th17 or Th2 differ...
https://doi.org/10.1038/s41467-021-25307-x 10.1111/imm.13006 10.1164/rccm.201109-1640OC 10.1164/ajrccm.156.3.9610046 10.1016/j.jaci.2009.02.024 10.1016/j.cell.2019.01.041 10.1111/cea.12119 10.4049/jimmunol.181.6.4089 10.1016/S0140-6736(10)61226-3 10.1016/j.cell.2011.08.010 10.1038/ni.2467 10.1126/science.1171243 10.1016/j.immuni.2012.10.016 10.4049/jimmunol.1402195 10.1002/cpim.39 10.4049/jimmunol.176.4.2161 10.4049/jimmunol.1101717 10.1084/jem.20091627 10.1016/j.celrep.2015.08.030 10.1111/j.0105-2896.2009.00874.x 10.1016/j.immuni.2020.05.005 10.1016/B978-0-12-417028-5.00009-0 10.1016/j.immuni.2013.04.011 10.1016/j.immuni.2013.08.028 10.1016/j.cell.2018.02.001 10.1016/j.immuni.2020.04.005 10.1111/j.1600-065X.2010.00951.x 10.1016/j.cell.2010.02.021 10.1038/nri2297 10.1038/mi.2012.106 10.1164/rccm.200904-0573OC 10.1289/ehp.1307280 10.1038/nm.2920 10.1038/mi.2014.56 10.1084/jem.20112675 10.1084/jem.20120030 10.1038/ni.2370 10.1038/ni.2419 10.1189/jlb.1A0616-285R 10.1016/j.immuni.2009.05.001 10.1038/sj.cdd.4402038 10.1016/j.ajpath.2012.03.044 10.1084/jem.20082394 10.1016/j.cell.2019.05.031 10.1016/j.immuni.2016.12.001 10.1038/nmeth.4380 10.1038/nbt.2859 10.1016/j.immuni.2015.04.017 10.1016/j.immuni.2011.08.013 10.1002/eji.201747332 10.1038/s41591-019-0468-5 10.1016/j.jaci.2017.10.023 10.1126/science.8171322 10.1038/ni.3200 10.1126/science.2898810 10.1182/blood-2016-02-698118 10.4049/jimmunol.177.10.7346 10.1016/j.immuni.2019.08.008 10.1161/01.CIR.0000057548.68243.42 10.1152/ajplung.00256.2015 10.1038/mi.2011.47 10.1007/978-1-62703-496-8_2 10.1084/jem.20081438 10.1093/bioinformatics/bts635 10.1093/bioinformatics/btt656 10.1186/s13059-014-0550-8
Nature Communications; Izumi G, Nakano H et. al.

Aug 21st, 2021 - Dendritic cells (DC) in the lung that induce Th17 differentiation remain incompletely understood, in part because conventional CD11b+ DCs (cDC2) are heterogeneous. Here, we report a population of cDCs that rapidly accumulates in lungs of mice following house dust extract inhalation. These cells are Ly-6C+, are developmentally and phenotypically similar to cDC2, and strongly promote Th17 differe...

Translational control by DHX36 binding to 5'UTR G-quadruplex is essential for muscle st...
https://doi.org/10.1038/s41467-021-25170-w 10.1007/s12015-012-9352-0 10.1242/dev.069088 10.1016/j.stem.2018.10.006 10.1038/s41536-018-0062-3 10.1038/nrm.2017.130 10.1073/pnas.1708725114 10.1016/j.celrep.2016.06.095 10.7554/eLife.03390 10.1128/MCB.23.14.4991-5004.2003 10.1016/S1097-2765(03)00481-7 10.1074/jbc.M806277200 10.1016/j.tibtech.2017.06.012 10.1093/nar/gkr630 10.1093/nar/gkq372 10.1016/j.celrep.2015.09.043 10.1016/j.jmb.2016.11.033 10.1038/s41467-019-10432-5 10.1182/blood-2011-08-362954 10.1038/cddis.2014.571 10.1016/j.devcel.2009.05.008 10.1016/j.celrep.2017.10.080 10.1242/jcs.112.17.2895 10.1007/978-1-4939-3810-0_6 10.1242/dev.064162 10.1186/1471-213X-1-4 10.1038/s41467-020-16553-6 10.1016/j.molcel.2009.12.003 10.1093/nar/gkp335 10.1038/nmeth.3965 10.1038/srep24793 10.1016/j.ymeth.2007.08.003 10.1093/nar/gks152 10.1002/anie.201709184 10.1093/nar/gki1012 10.1093/bioinformatics/btk010 10.1126/science.283.5405.1168 10.1038/nature13923 10.1128/MCB.00957-13 10.1002/anie.201500891 10.1002/anie.201206281 10.1002/anie.201801999 10.1016/j.jmb.2017.05.017 10.1016/j.molcel.2018.04.001 10.1093/nar/gky861 10.1093/nar/gkz1138 10.1074/jbc.M804857200 10.1016/j.cell.2015.09.015 10.1016/j.molcel.2019.09.014 10.1002/anie.201300058 10.1021/ac402497x 10.1093/nar/gkt1022 10.1073/pnas.1212533110 10.1016/j.cell.2013.09.060 10.1038/nature08209 10.1186/s13059-016-1012-2 10.1038/celldisc.2017.2 10.1038/cr.2015.21 10.1038/ncomms10026 10.1039/C8CC09929D 10.1039/C8CC04635B 10.1186/gb-2013-14-4-r36 10.1038/nprot.2012.016 10.12688/f1000research.15931.1 10.1093/bioinformatics/btu170 10.1038/nmeth.1923 10.1093/bioinformatics/bts569 10.1093/nar/gku365 10.1093/bioinformatics/btq033 10.1016/j.molcel.2010.05.004 10.1093/bioinformatics/btr064 10.1101/gr.849004 10.1093/nar/gkh103 10.1016/j.bbagrm.2017.12.006 10.1093/nar/gkv1238 10.1186/1748-7188-6-26 10.15252/msb.156240 10.1038/s41467-019-13598-0 10.1038/nbt.1621 10.1089/omi.2011.0118 10.1186/gb-2007-8-9-r183
Nature Communications; Chen X, Yuan J et. al.

Aug 21st, 2021 - Skeletal muscle has a remarkable ability to regenerate owing to its resident stem cells (also called satellite cells, SCs). SCs are normally quiescent; when stimulated by damage, they activate and expand to form new fibers. The mechanisms underlying SC proliferative progression remain poorly understood. Here we show that DHX36, a helicase that unwinds RNA G-quadruplex (rG4) structures, is essen...

Brain-trait-associated variants impact cell-type-specific gene regulation during neurog...
https://doi.org/10.1016/j.ajhg.2021.07.011
American Journal of Human Genetics; Aygün N, Elwell AL et. al.

Aug 21st, 2021 - Interpretation of the function of non-coding risk loci for neuropsychiatric disorders and brain-relevant traits via gene expression and alternative splicing quantitative trait locus (e/sQTL) analyses is generally performed in bulk post-mortem adult tissue. However, genetic risk loci are enriched in regulatory elements active during neocortical differentiation, and regulatory effects of risk var...

Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373975
Nature Communications; Di Franco S, Bianca P et. al.

Aug 20th, 2021 - Obesity is a strong risk factor for cancer progression, posing obesity-related cancer as one of the leading causes of death. Nevertheless, the molecular mechanisms that endow cancer cells with metastatic properties in patients affected by obesity remain unexplored.Here, we show that IL-6 and HGF, secreted by tumor neighboring visceral adipose stromal cells (V-ASCs), expand the metastatic colore...