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About 417,263 results

Mangiferin promotes the osteogenic differentiation of human periodontal ligament stem c...
https://doi.org/10.3892/mmr.2022.12782
Molecular Medicine Reports; Gu Y, Zhang L et. al.

Jun 29th, 2022 - Mangiferin (MAG) is a polyphenolic compound present in mangoes. This compound suppresses inflammation and decreases bone destruction. This study aimed to determine whether MAG directly promotes proliferation and osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs). Cell proliferation and osteogenic differentiation experiments were performed in hPDLSCs, and MAG was used ...

Upregulation of SIRT1 by Evodiamine activates PI3K/AKT pathway and blocks intervertebra...
https://doi.org/10.3892/mmr.2022.12781
Molecular Medicine Reports; Kuai J, Zhang N

Jun 29th, 2022 - Intervertebral disc degeneration (IDD) is a major cause of a number of spinal diseases, resulting in serious public health problems. Evodiamine (Evo) is an indole quinazoline alkaloid extracted from Evodia rutaecarpa, which has antioxidant, anti‑apoptosis and anti‑inflammatory effects. The purpose of the present study was to investigate lipopolysaccharide (LPS)‑induced IDD progression in human ...

Bacterial envelope built to a peptidoglycan tune.
https://doi.org/10.1038/d41586-022-01739-3 10.1038/s41586-022-04834-7 10.1101/cshperspect.a000414 10.1016/j.mib.2021.01.009 10.1038/nature14461 10.1128/jb.122.1.295-301.1975 10.1371/journal.pcbi.1002680 10.1128/jb.135.2.687-702.1978 10.1128/jb.159.2.440-447.1984 10.1038/s41579-020-0366-3 10.1002/anie.201206749 10.1073/pnas.1415955112 10.1038/s41586-019-1791-1 10.1038/s41586-021-03455-w 10.1021/acsinfecdis.0c00728
Nature Deghelt M, Collet JF

Jun 28th, 2022 - Bacterial envelope built to a peptidoglycan tune.|2022|Deghelt M,Collet JF,|cytology,metabolism,metabolism,

IFT80 negatively regulates osteoclast differentiation via association with Cbl-b to dis...
https://doi.org/10.1073/pnas.2201490119
Proceedings of the National Academy of Sciences of the Un... Deepak V, Yang ST et. al.

Jun 24th, 2022 - Excess bone loss due to increased osteoclastogenesis is a significant clinical problem. Intraflagellar transport (IFT) proteins have been reported to regulate cell growth and differentiation. The role of IFT80, an IFT complex B protein, in osteoclasts (OCs) is completely unknown. Here, we demonstrate that deletion of IFT80 in the myeloid lineage led to increased OC formation and activity accomp...

Action-driven remapping of hippocampal neuronal populations in jumping rats.
https://doi.org/10.1073/pnas.2122141119
Proceedings of the National Academy of Sciences of the Un... Green L, Tingley D et. al.

Jun 24th, 2022 - The current dominant view of the hippocampus is that it is a navigation "device" guided by environmental inputs. Yet, a critical aspect of navigation is a sequence of planned, coordinated actions. We examined the role of action in the neuronal organization of the hippocampus by training rats to jump a gap on a linear track. Recording local field potentials and ensembles of single units in the h...

Isotype-specific plasma cells express divergent transcriptional programs.
https://doi.org/10.1073/pnas.2121260119
Proceedings of the National Academy of Sciences of the Un... Higgins BW, Shuparski AG et. al.

Jun 16th, 2022 - Antibodies are produced across multiple isotypes with distinct properties that coordinate initial antigen clearance and confer long-term antigen-specific immune protection. Here, we interrogate the molecular programs of isotype-specific murine plasma cells (PC) following helper T cell-dependent immunization and within established steady-state immunity. We developed a single-cell-indexed and tar...

Lifelong multilineage contribution by embryonic-born blood progenitors.
https://doi.org/10.1038/s41586-022-04804-z 10.1038/nature08738 10.1038/nature08764 10.1242/dev.125.22.4575 10.1242/dev.051094 10.1038/ni1560 10.1242/dev.040998 10.1182/blood-2014-07-588954 10.1038/nature07619 10.1242/dev.129.21.4891 10.1242/dev.131193 10.1016/j.stem.2009.08.020 10.1038/nature17997 10.1016/j.stem.2018.04.015 10.1038/nature23653 10.1038/ncb3607 10.1038/ncb3444 10.1016/j.stemcr.2017.04.003 10.1182/blood.2020004801 10.1038/s41467-018-04893-3 10.1038/nature13824 10.1016/j.stem.2015.05.003 10.1016/j.cell.2020.04.048 10.1073/pnas.261562798 10.1016/j.stem.2011.04.021 10.1186/1471-213X-1-4 10.1038/s41586-020-1971-z 10.1038/s41467-018-07769-8 10.1038/nature25168 10.1371/journal.pgen.0010028 10.1038/ni1033 10.3389/fcell.2020.618164 10.1038/nn.2467 10.1038/nprot.2011.441 10.1101/gr.177881.114 10.1038/s41586-019-0969-x 10.1038/s41467-018-03214-y
Nature Patel SH, Christodoulou C et. al.

Jun 16th, 2022 - Haematopoietic stem cells (HSCs) arise in the embryo from the arterial endothelium through a process known as the endothelial-to-haematopoietic transition (EHT)1-4. This process generates hundreds of blood progenitors, of which a fraction go on to become definitive HSCs. It is generally thought that most adult blood is derived from those HSCs, but to what extent other progenitors contribute to ...

COVID-19 Infection in Patients with Comorbidities: Clinical and Immunological Insight.
https://doi.org/10.1177/10760296221107889
Clinical and Applied Thrombosis/hemostasis : Official Jou... El-Badawy O, Elsherbiny NM et. al.

Jun 15th, 2022 - Our study's objectives were to study the clinical and laboratory characteristics that may serve as biomarkers for predicting disease severity, IL-10 levels, and frequencies of different T cell subsets in comorbid COVID-19 patients. Sixty-two hospitalized COVID-19 patients with comorbidities were assessed clinically and radiologically. Blood samples were collected to assess the T lymphocyte subs...

Social stressors associated with age-related T lymphocyte percentages in older US adult...
https://doi.org/10.1073/pnas.2202780119
Proceedings of the National Academy of Sciences of the Un... Klopack ET, Crimmins EM et. al.

Jun 14th, 2022 - Exposure to stress is a risk factor for poor health and accelerated aging. Immune aging, including declines in naïve and increases in terminally differentiated T cells, plays a role in immune health and tissue specific aging, and may contribute to elevated risk for poor health among those who experience high psychosocial stress. Past data have been limited in estimating the contribution of life...

Transcriptional and functional motifs defining renal function revealed by single-nucleu...
https://doi.org/10.1073/pnas.2203179119
Proceedings of the National Academy of Sciences of the Un... Xu J, Liu Y et. al.

Jun 14th, 2022 - Recent advances in single-cell sequencing provide a unique opportunity to gain novel insights into the diversity, lineage, and functions of cell types constituting a tissue/organ. Here, we performed a single-nucleus study of the adult Drosophila renal system, consisting of Malpighian tubules and nephrocytes, which shares similarities with the mammalian kidney. We identified 11 distinct clusters...

Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndr...
https://doi.org/10.1186/s40478-022-01385-w 10.1007/BF00191452 10.1016/s0736-5748(96)00073-1 10.1186/s40478-020-01015-3 10.1016/0006-8993(91)90695-R 10.1002/cne.902820204 10.1016/j.bbadis.2011.10.001 10.1523/JNEUROSCI.3406-07.2007 10.1002/hipo.20308 10.3389/fncel.2017.00054 10.1007/s12035-018-0914-2 10.1186/s40478-018-0559-4 10.1002/cne.903420307 10.1111/j.1399-0004.2007.00822.x 10.1016/j.neuroscience.2017.12.037 10.1038/nn1860 10.1159/000442941 10.1074/jbc.M111.227421 10.1371/journal.pone.0025194 10.1523/JNEUROSCI.3728-10.2010 10.1016/s0896-6273(00)80778-3 10.1186/s11689-017-9220-y 10.1097/00005072-199409000-00011 10.1016/j.jchemneu.2003.09.005 10.1043/0003-9985(2001)125 10.1016/j.jalz.2014.10.007 10.1016/j.tins.2011.11.001 10.1093/jnen/62.9.917 10.1007/978-1-4899-6704-6_6 10.1016/bs.pbr.2019.05.003 10.1016/j.stemcr.2018.02.001 10.1016/j.neuroimage.2013.04.080 10.1016/j.biocel.2012.05.001 10.1016/j.neumeth.2009.07.010 10.1016/0304-3940(90)90487-t 10.1016/j.aanat.2008.05.007 10.1016/j.neuron.2013.01.011 10.1016/j.molmed.2019.10.001 10.1006/nbdi.1996.0003 10.1186/s13024-020-00414-3 10.1093/cercor/8.7.660 10.1038/s41582-018-0132-6 10.1371/journal.pone.0022126 10.1093/hmg/dds052 10.1111/j.1365-2788.2006.00902.x 10.1523/JNEUROSCI.1203-12.2013 10.1038/nature02621 10.1016/0006-8993(91)90901-7 10.3389/fnagi.2019.00034 10.1111/nan.12406 10.1006/exnr.1993.1052 10.3390/jcm10153414 10.1002/cne.902710306 10.1016/j.febslet.2013.05.010 10.1242/dev.108712 10.1146/annrev-neuro-061010-113613 10.1007/s00429-011-0329-6 10.1016/j.stemcr.2018.05.004 10.1126/science.aaf7073 10.1016/j.nicl.2019.102139 10.1007/s00401-019-01965-6 10.1002/prca.201300066 10.1016/0014-4886(84)90041-4 10.1523/JNEUROSCI.20-13-05012.2000 10.1016/j.neulet.2007.12.039 10.1002/(SICI)1097-4652(200003)182 10.1038/mp.2014.147 10.1007/s00580-101-1149-4 10.1007/978-3-642-55557-2_2 10.1080/17518420903090701 10.1001/jama.2013.6235 10.1016/j.freeradbiomed.2017.07.026 10.1016/S0002-944(10)64753-0 10.1016/s0387-7604(89)80082-8 10.1038/nm0196-93 10.1007/978-3-642-59425-0 10.1093/cercor/bhh089 10.3389/fnagi.2016.00274 10.1002/ajmg.1320370755 10.3389/fnins.2020.00660 10.1111/j.1471-4159.2009.05882.x 10.1113/JP275369
Acta Neuropathologica Communications; Utagawa EC, Moreno DG et. al.

Jun 9th, 2022 - Although Down syndrome (DS), the most common developmental genetic cause of intellectual disability, displays proliferation and migration deficits in the prenatal frontal cortex (FC), a knowledge gap exists on the effects of trisomy 21 upon postnatal cortical development. Here, we examined cortical neurogenesis and differentiation in the FC supragranular (SG, II/III) and infragranular (IG, V/VI...

Primary cilia in satellite cells are the mechanical sensors for muscle hypertrophy.
https://doi.org/10.1073/pnas.2103615119
Proceedings of the National Academy of Sciences of the Un... Li W, Zhu Z et. al.

Jun 8th, 2022 - Skeletal muscle atrophy is commonly associated with aging, immobilization, muscle unloading, and congenital myopathies. Generation of mature muscle cells from skeletal muscle satellite cells (SCs) is pivotal in repairing muscle tissue. Exercise therapy promotes muscle hypertrophy and strength. Primary cilium is implicated as the mechanical sensor in some mammalian cells, but its role in skeleta...

Differential Responses of Human Dental Pulp Stromal Cells to Bioceramic Materials: A Co...
https://www.ncbi.nlm.nih.gov/pubmed/35656675
The Journal of Contemporary Dental Practice; Ali MR, Mustafa M et. al.

Jun 4th, 2022 - The aim of this study was to compare the effects of white MTA-Angelus (wMTA), Biodentine® (Biodentine) and TotalFill® BC Root Repair MaterialTM putty (TotalFill) on human dental pulp stromal cells (hDPSCs) in vitro. hDPSCs were isolated from third molars of healthy young adults. Material elutes at different concentrations were prepared. Cells were exposed to the eluates for 1, 3, and 7 days. Ce...

Cell proliferation effects of S-allyl-L-cysteine are associated with phosphorylation of...
https://doi.org/10.1016/j.ejphar.2022.175067
European Journal of Pharmacology; Moteki H, Ogihara M et. al.

Jun 3rd, 2022 - The cell proliferation effect of S-allyl-L-cysteine (SAC) and its mechanisms were examined in primary cultures of adult rat hepatocytes. In serum-free cultivation, SAC (10-6 M)-stimulated hepatocytes showed significant proliferation compared to control at 5-h culture; the effect was dependent on the culture time and the dose of SAC (EC50 value 8.58 × 10-8 M). In addition, SAC-stimulated hepatoc...

Clonal dynamics of haematopoiesis across the human lifespan.
https://doi.org/10.1038/s41586-022-04786-y
Nature Mitchell E, Spencer Chapman M et. al.

Jun 2nd, 2022 - Age-related change in human haematopoiesis causes reduced regenerative capacity1, cytopenias2, immune dysfunction3 and increased risk of blood cancer4-6, but the reason for such abrupt functional decline after 70 years of age remains unclear. Here we sequenced 3,579 genomes from single cell-derived colonies of haematopoietic cells across 10 human subjects from 0 to 81 years of age. Haematopoiet...

The longitudinal dynamics and natural history of clonal haematopoiesis.
https://doi.org/10.1038/s41586-022-04785-z
Nature Fabre MA, de Almeida JG et. al.

Jun 2nd, 2022 - Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis1-4. The understanding of how and when clonal haematopoiesis develops, the factors that govern its behaviour, how it interacts with ageing and how these variables relate to malignant progression remains limited5...

Molecularly defined circuits for cardiovascular and cardiopulmonary control.
https://doi.org/10.1038/s41586-022-04760-8
Nature Veerakumar A, Yung AR et. al.

Jun 2nd, 2022 - The sympathetic and parasympathetic nervous systems regulate the activities of internal organs1, but the molecular and functional diversity of their constituent neurons and circuits remains largely unknown. Here we use retrograde neuronal tracing, single-cell RNA sequencing, optogenetics and physiological experiments to dissect the cardiac parasympathetic control circuit in mice. We show that c...

Transforming dysfunctional CD8+ T cells into natural controller-like CD8+ T cells: can ...
https://doi.org/10.1172/JCI160474
The Journal of Clinical Investigation; Takata H, Trautmann L

Jun 2nd, 2022 - HIV infection results in defective CD8+ T cell functions that are incompletely resolved by antiretroviral therapy (ART) except in natural controllers, who have functional CD8+ T cells associated with viral control. In this issue of the JCI, Perdomo-Celis et al. demonstrated that targeting the Wnt/transcription factor T cell factor 1 (Wnt/TCF-1) pathway in dysfunctional CD8+ T cells led to gains...

Kv1.1 preserves the neural stem cell pool and facilitates neuron maturation during adul...
https://doi.org/10.1073/pnas.2118240119
Proceedings of the National Academy of Sciences of the Un... Lin King YH, Chen C et. al.

May 26th, 2022 - SignificanceDespite decades of research on adult neurogenesis, little is known about the role of bioelectric signaling in this process. In this study, we describe how a voltage-gated potassium channel, Kv1.1, supports adult neurogenesis by maintaining the neural stem cell niche and facilitating newborn neuron development. Additionally, we show that deletion of Kv1.1 from adult neural stem cells...

The HDAC inhibitor CI-994 acts as a molecular memory aid by facilitating synaptic and i...
https://doi.org/10.1073/pnas.2116797119
Proceedings of the National Academy of Sciences of the Un... Burns AM, Farinelli-Scharly M et. al.

May 26th, 2022 - SignificanceMemory formation relies on a plethora of functions, including epigenetic modifications. Over recent years, multiple studies have indicated the potential of HDAC inhibitors (HDACis) as cognitive enhancers, but their mode of action is not fully understood. Here, we tested whether HDACi treatment improves memory formation via "cognitive epigenetic priming," stipulating that HDACis-with...