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Screening for Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults: U...
https://doi.org/10.1001/jama.2018.14741
JAMA , Curry SJ et. al.

Oct 25th, 2018 - Intimate partner violence (IPV) and abuse of older or vulnerable adults are common in the United States but often remain undetected. In addition to the immediate effects of IPV, such as injury and death, there are other health consequences, many with long-term effects, including development of mental health conditions such as depression, posttraumatic stress disorder, anxiety disorders, substan...

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus.
https://doi.org/10.1056/NEJMoa1803760
The New England Journal of Medicine; Fenske W, Refardt J et. al.

Aug 1st, 2018 - The indirect water-deprivation test is the current reference standard for the diagnosis of diabetes insipidus. However, it is technically cumbersome to administer, and the results are often inaccurate. The current study compared the indirect water-deprivation test with direct detection of plasma copeptin, a precursor-derived surrogate of arginine vasopressin. From 2013 to 2017, we recruited 156...

Predictors of pneumonia in lower respiratory tract infections: 3C prospective cough com...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724402
The European Respiratory Journal; Moore M, Stuart B et. al.

Nov 23rd, 2017 - The aim was to aid diagnosis of pneumonia in those presenting with lower respiratory tract symptoms in routine primary care.A cohort of 28 883 adult patients with acute cough attributed to lower respiratory tract infections (LRTIs) was recruited from 5222 UK practices in 2009-13. Symptoms, signs and treatment were recorded at presentation and subsequent events followed-up for 30 days by chart r...

Risk of post-pregnancy hypertension in women with a history of hypertensive disorders o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506851
BMJ (Clinical Research Ed.); Behrens I, Basit S et. al.

Jul 13th, 2017 - Objectives To determine how soon after delivery the risk of post-pregnancy hypertension increases in women with hypertensive disorders of pregnancy and how the risk evolves over time.Design Nationwide register based cohort study.Setting Denmark.Populations 482 972 primiparous women with a first live birth or stillbirth between 1995 and 2012 (cumulative incidence analyses), and 1 025 118 women w...

Efficacy of Laparoscopic Nissen Fundoplication vs Transoral Incisionless Fundoplication...
https://doi.org/10.1053/j.gastro.2017.12.021
Gastroenterology Richter JE, Kumar A et. al.

Jan 6th, 2018 - The effects of transoral incisionless fundoplication (TIF) and laparoscopic Nissen fundoplication (LNF) have been compared with those of proton pump inhibitors (PPIs) or a sham procedure in patients with gastroesophageal reflux disease (GERD), but there has been no direct comparison of TIF vs LNF. We performed a systematic review and network meta-analysis of randomized controlled trials to comp...

Cystic Fibrosis Colorectal Cancer Screening Consensus Recommendations.
https://doi.org/10.1053/j.gastro.2017.12.012
Gastroenterology Hadjiliadis D, Khoruts A et. al.

Dec 31st, 2017 - Improved therapy has substantially increased survival of persons with cystic fibrosis (CF). But the risk of colorectal cancer (CRC) in adults with CF is 5-10 times greater compared to the general population, and 25-30 times greater in CF patients after an organ transplantation. To address this risk, the CF Foundation convened a multi-stakeholder task force to develop CRC screening recommendatio...

Acquisition of wild-type HIV-1 infection in a patient on pre-exposure prophylaxis with ...
https://doi.org/10.1016/S2352-3018(17)30132-7
The Lancet. HIV; Hoornenborg E, Prins M et. al.

Sep 18th, 2017 - Pre-exposure prophylaxis (PrEP) with emtricitabine and tenofovir disoproxil fumarate is highly effective against acquisition of HIV infection, and only two cases of infection with a multidrug-resistant virus have been reported under adequate long-term adherence, as evidenced by tenofovir diphosphate concentrations in dried blood spots. We report a case of wild-type HIV-1 infection despite consi...

Effect of Colonoscopy Outreach vs Fecal Immunochemical Test Outreach on Colorectal Canc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648645
JAMA Singal AG, Gupta S et. al.

Sep 5th, 2017 - Mailed fecal immunochemical test (FIT) outreach is more effective than colonoscopy outreach for increasing 1-time colorectal cancer (CRC) screening, but long-term effectiveness may need repeat testing and timely follow-up for abnormal results. Compare the effectiveness of FIT outreach and colonoscopy outreach to increase completion of the CRC screening process (screening initiation and follow-u...

Risk of recurrence after a single manic or mixed episode - a systematic review and meta...
https://doi.org/10.1111/bdi.12593
Bipolar Disorders; Kessing LV, Andersen PK et. al.

Dec 14th, 2017 - For the first time to estimate the risk of recurrence among patients with a single manic/mixed episode by systematically reviewing prior studies on cohorts of adults, and cohorts of children and adolescents, respectively. A systematic literature search up to August 2017 was carried out including studies in which < 25% of the participants were estimated to have had a mood episode that required p...

Public health impact of colonoscopy use on colorectal cancer mortality in Germany and t...
https://doi.org/10.1016/j.gie.2017.04.005
Gastrointestinal Endoscopy; Chen C, Stock C et. al.

Apr 22nd, 2017 - Colonoscopy has been demonstrated to be effective in reducing colorectal cancer (CRC) incidence and mortality and has been widely used for primary CRC screening in Germany and the United States. We performed a population-based analysis to evaluate and compare the public health impact of recent colonoscopy use on CRC deaths among adults aged 55 to 79 years in Germany and the United States from 2...

Rheumatoid Arthritis Treatment After Methotrexate: The Durability of Triple Therapy Ver...
https://doi.org/10.1002/acr.23255
Arthritis Care & Research; Peper SM, Lew R et. al.

Apr 7th, 2017 - Although it is common for rheumatologists to initiate biologic agents after failure of methotrexate monotherapy in rheumatoid arthritis (RA), ample data support the initial use of combinations of conventional therapies in this clinical scenario. Our study explores the durability of triple therapy (methotrexate, sulfasalazine, and hydroxychloroquine) versus methotrexate-etanercept in RA. RA pati...

Time to Epinephrine Administration and Survival From Nonshockable Out-of-Hospital Cardi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940513
Circulation Hansen M, Schmicker RH et. al.

Mar 7th, 2018 - Previous studies have demonstrated that earlier epinephrine administration is associated with improved survival from out-of-hospital cardiac arrest (OHCA) with shockable initial rhythms. However, the effect of epinephrine timing on patients with nonshockable initial rhythms is unclear. The objective of this study was to measure the association between time to epinephrine administration and surv...

Effectiveness of fluticasone furoate plus vilanterol on asthma control in clinical prac...
https://doi.org/10.1016/S0140-6736(17)32397-8
Lancet (London, England); Woodcock A, Vestbo J et. al.

Sep 14th, 2017 - Evidence for management of asthma comes from closely monitored efficacy trials done in highly selected patient groups. There is a need for randomised trials that are closer to usual clinical practice. We did an open-label, randomised, controlled, two-arm effectiveness trial at 74 general practice clinics in Salford and South Manchester, UK. Patients aged 18 years or older with a general practit...

Identification of Extremely Premature Infants at Low Risk for Early-Onset Sepsis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654397
Pediatrics Puopolo KM, Mukhopadhyay S et. al.

Oct 6th, 2017 - Premature infants are at high risk of early-onset sepsis (EOS) relative to term infants, and most are administered empirical antibiotics after birth. We aimed to determine if factors evident at birth could be used to identify premature infants at lower risk of EOS. Study infants were born at 22 to 28 weeks' gestation in Neonatal Research Network centers from 2006 to 2014. EOS was defined by iso...

Comorbidity in multiple sclerosis is associated with diagnostic delays and increased mo...
https://doi.org/10.1212/WNL.0000000000004508
Neurology Thormann A, Sørensen PS et. al.

Sep 21st, 2017 - To investigate the effect of chronic comorbidity on the time of diagnosis of multiple sclerosis (MS) and on mortality in MS. We conducted a population-based, nationwide cohort study including all incident MS cases in Denmark with first MS symptom between 1980 and 2005. To investigate the time of diagnosis, we compared individuals with and without chronic comorbidity using multinomial logistic r...

Effect of Dermatology Consultation on Outcomes for Patients With Presumed Cellulitis: A...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876891
JAMA Dermatology; Ko LN, Garza-Mayers AC et. al.

Feb 17th, 2018 - Each year, cellulitis leads to 650 000 hospital admissions and is estimated to cost $3.7 billion in the United States. Previous literature has demonstrated a high misdiagnosis rate for cellulitis, which results in unnecessary antibiotic use and health care cost. To determine whether dermatologic consultation decreases duration of hospital stay or intravenous antibiotic treatment duration in pat...

Outcomes of Early Dermatology Consultation for Inpatients Diagnosed With Cellulitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876861
JAMA Dermatology; Li DG, Xia FD et. al.

Feb 17th, 2018 - Many inflammatory skin dermatoses mimic cellulitis (pseudocellulitis) and are treated with antibiotics and/or hospitalization, leading to unnecessary patient morbidity and substantial health care spending. To evaluate the impact of early dermatology consultation on clinical and economic outcomes associated with misdiagnosed cellulitis. This prospective cohort study enrolled patients with presum...

Safety and feasibility of a diagnostic algorithm combining clinical probability, d-dime...
https://doi.org/10.7326/M13-2056
Annals of Internal Medicine; Kleinjan A, Di Nisio M et. al.

Apr 1st, 2014 - Although well-established for suspected lower limb deep venous thrombosis, an algorithm combining a clinical decision score, d-dimer testing, and ultrasonography has not been evaluated for suspected upper extremity deep venous thrombosis (UEDVT). To assess the safety and feasibility of a new diagnostic algorithm in patients with clinically suspected UEDVT. Diagnostic management study. (Clinical...

Screening for cognitive impairment in older adults: U.S. Preventive Services Task Force...
https://doi.org/10.7326/M14-0496
Annals of Internal Medicine; Moyer VA,

Mar 25th, 2014 - Update of the 2003 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for dementia. The USPSTF reviewed the evidence on the benefits, harms, and sensitivity and specificity of screening instruments for cognitive impairment in older adults and the benefits and harms of commonly used treatment and management options for older adults with mild cognitive impairment or early de...

Pregnancy outcome following in utero exposure to lithium: a prospective, comparative, o...
https://doi.org/10.1176/appi.ajp.2014.12111402
The American Journal of Psychiatry; Diav-Citrin O, Shechtman S et. al.

May 1st, 2014 - The authors conducted a prospective, comparative observational study to evaluate the risk of major anomalies following exposure to lithium during pregnancy. A total of 183 lithium-exposed pregnancies of women who contacted the Israeli Teratology Information Service were followed up (90.2% in the first trimester) and compared with 72 disease-matched and 748 nonteratogenic-exposed pregnancies. Th...