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About 1,757,098 results

Acute Perforated Appendicitis Associated with Appendiceal Diverticulitis in a Young Man...
https://doi.org/10.12659/AJCR.934838
The American Journal of Case Reports; Abdulmomen AA, AlZahrani AS et. al.

Jan 14th, 2022 - BACKGROUND Diverticulosis of the vermiform appendix is rare. In patients who present with appendicitis, appendiceal diverticulitis as a cause due is also rare. We report the case of a 35-year-old man who presented with typical symptoms and signs of acute appendicitis, which was confirmed by histopathology to be due to perforated acute appendiceal diverticulitis. CASE REPORT A 35-year-old man pr...

Just breathe: a review of sex and gender in chronic lung disease.
https://doi.org/10.1183/16000617.0111-2021
European Respiratory Review : an Official Journal of the ... Somayaji R, Chalmers JD

Jan 14th, 2022 - Chronic lung diseases are the third leading cause of death worldwide and are increasing in prevalence over time. Although much of our traditional understanding of health and disease is derived from study of the male of the species - be it animal or human - there is increasing evidence that sex and gender contribute to differences in disease risk, prevalence, presentation, severity, treatment ap...

The evolving landscape of sex-based differences in lung cancer: a distinct disease in w...
https://doi.org/10.1183/16000617.0100-2021
European Respiratory Review : an Official Journal of the ... Ragavan M, Patel MI

Jan 14th, 2022 - In stark contrast to a few decades ago when lung cancer was predominantly a disease of men who smoke, incidence rates of lung cancer in women are now comparable to or higher than those in men and are rising alarmingly in many parts of the world. Women face a unique set of risk factors for lung cancer compared to men. These include exogenous exposures including radon, prior radiation, and fumes ...

Acquired scrotal lymphangiectasia, a long-term sequela of penile carcinoma: diagnosis a...
https://doi.org/10.1136/bcr-2021-246376
BMJ Case Reports; Tosh JM, Jindal R et. al.

Jan 14th, 2022 - Acquired lymphangiectasia is an unique entity encountered by an urologist which is marked by occlusion of lymphatics associated with abnormal permanent dilation of cutaneous lymphatics. There is presence of thin-walled ectatic vessels in the superficial and mid dermis, which develops later in life. Trauma, infection, radiation or surgery are important causes of this rare aetiology. Diagnosis is...

Biomarker-Driven Analysis Using High-Throughput Approaches in Neuroinflammation and Neu...
https://doi.org/10.1007/978-3-030-78787-5_8 10.1007/s10973-019-08610-0 10.3390/ijms20236008 10.1038/s41593-018-0221-2 10.1136/bjophthalmol-2015-308329 10.2741/e811 10.3233/JAD-190863 10.3390/ijms18020248 10.1155/2015/964518 10.3233/JAD-160763 10.1016/j.mehy.2013.09.008 10.1016/j.freeradbiomed.2012.09.027 10.1016/S0197-4580(01)00257-3 10.1097/00002093-200207000-00005 10.1007/s11064-009-9960-5 10.1586/14737175.8.11.1703 10.1038/s41582-020-0344-4 10.3389/fmolb.2015.00054 10.1097/COH.0b013e32833ed177 10.3389/fneur.2015.00256 10.1586/14737159.2016.1133298 10.2353/jmoldx.2006.060012 10.1093/hmg/ddu203 10.1038/nrg.2017.117 10.15252/msb.20156351 10.1017/S0033583516000160 10.1002/cpps.62
Advances in Experimental Medicine and Biology; Krokidis MG

Jan 14th, 2022 - Aging is responsible for homeostatic dysregulation and the primary risk for neurodegenerative diseases. The main signaling pathways may regulate inflammatory-related disorders and neurodegeneration include genomic instability, cell senescence, and mitochondria dysfunction. The use of high-throughput technologies has emerged as a powerful approach to the rapid discovery of many candidate biomark...

The Role of Inflammatory Biomarkers as a Diagnostic Tool for Possible Late-Life Cogniti...
https://doi.org/10.1007/978-3-030-78787-5_6 10.3233/JAD-2010-101671 10.1186/s12979-017-0106-3 10.1016/j.cger.2013.07.002 10.1038/srep26712 10.1055/s-0035-1555115 10.1016/j.clinbiochem.2011.07.011 10.1177/0891988709351832 10.3233/JAD-122071 10.1177/1535370216638770 10.1016/j.jalz.2009.01.025 10.1097/JNN.0b013e3182527690 10.1212/WNL.0b013e3182698c89 10.7150/ijms.12742 10.1097/COH.0b013e32833ed177 10.1136/jnnp.2005.082867 10.1001/archneurol.2011.670 10.1097/MD.0000000000015605 10.1212/WNL.0000000000007094 10.1159/000442585 10.1111/jgs.12994 10.1016/j.jns.2013.05.028
Advances in Experimental Medicine and Biology; Katsoulaki M, Kastrinis A et. al.

Jan 14th, 2022 - The objective of this paper was to explore whether inflammatory biomarkers, especially C-reactive protein (CRP) and high-sensitivity CRP (hsCRP), can be used as a diagnostic tool for possible late-life cognitive decline and dementias. Twelve studies were identified since 2010 involving 13,174 subjects, and one study recruited only healthy population. Inflammatory biomarkers CRP and hsCRP were o...

The Importance of Diagnostic and Prognostic Biomarker Identification and Classification...
https://doi.org/10.1007/978-3-030-78787-5_16
Advances in Experimental Medicine and Biology; Kadena K, Vlamos P

Jan 14th, 2022 - ALS is increasingly perceived as a multisystem neurodegenerative disorder, and the identification of a panel of biomarkers that accurately reflect features of pathology is a priority, not only for diagnostic purposes but also for prognostic or predictive applications [1]. Thus, as a multisystemic disease, it is likely that a panel of biomarkers will be needed to fully capture the features of AL...

Design and Validation of a New Diagnostic Tool for the Differentiation of Pathological ...
https://doi.org/10.1007/978-3-030-78787-5_11 10.1016/j.otohns.2009.06.744 10.1155/2009/203790 10.1145/2512530.2512533 10.1038/sdata.2016.11 10.1016/j.neunet.2017.02.013 10.1016/j.imu.2019.100231 10.1016/j.procs.2016.07.014 10.1016/j.protcy.2013.12.124 10.1109/ACCESS.2018.2856238
Advances in Experimental Medicine and Biology; Almaloglou EEI, S G et. al.

Jan 14th, 2022 - Pathological speech, in its many forms, is a symptom of numerous serious diseases affecting millions of people worldwide, including more than 10 million Parkinson patients. Here, a powerful method is proposed for detecting pathological speech, using a two-dimensional (2D) convolutional neural network (CNN). Spectrograms are extracted from voice recordings of healthy and Parkinson diagnosed pati...

Ebola Virus Disease and Current Therapeutic Strategies: A Review.
https://doi.org/10.1007/978-3-030-78787-5_18 10.1213/ane.0000000000000866 10.1016/j.idc.2019.08.005 10.1039/c5mb00706b 10.7717/peerj.74 10.1007/s11786-016-0287-8 10.1007/s001140050562 10.7717/peerj.85 10.1016/S0140-6736(10)60667-8 10.1136/bmj.g7348 10.1146/annurev-pathol-052016-100506 10.1155/2013/645348 10.1155/2013/108910 10.1177/1099800403252603 10.1016/S0140-6736(18)33132-5 10.1186/1471-2148-10-193 10.1093/oxfordjournals.molbev.a025820 10.1126/science.290.5493.923 10.1099/0022-1317-49-2-333 10.1126/science.1172705 10.1016/0140-6736(90)90737-p 10.1016/s0140-6736(95)90925-7 10.1371/journal.ppat.1000212 10.1038/nature19790 10.1371/journal.pntd.0007965 10.1128/cmr.00003-16 10.1186/s12985-018-0985-8 10.1371/journal.pone.0212113 10.1093/infdis/jix584 10.3390/v11080678 10.1128/cmr.00003-16 10.1021/acscentsci.0c00489 10.1016/j.cell.2020.03.011 10.1136/bmjgh-2019-001955 10.1056/NEJMra1901594
Advances in Experimental Medicine and Biology; Diakou KI, Mitsis T et. al.

Jan 14th, 2022 - The Ebola virus disease is a severe hemorrhagic fever that affects humans and other primates. Ebola virus, the causative agent of the disease, is transmitted to humans from wild animals and is highly contagious and aggressive with an estimated fatality rate to be around 50%. Since 1976, 11 outbreaks of Ebola virus disease have been reported in total, affecting mostly sub-Saharan Africa, while t...

Entropy in Cardiac Autonomic Nervous System of Adolescents with General Learning Disabi...
https://doi.org/10.1007/978-3-030-78787-5_17 10.1093/pch/11.9.581 10.1016/s0140-6736(12)60198-6 10.1177/0022219411407772 10.1371/journal.pone.0158753 10.1016/j.is.2015.04.007 10.1016/0169-2607(95)01684-l 10.1038/s41597-020-00583-2 10.1371/journal.pone.0233855 10.1371/journal.pone.0237901 10.1136/bmjopen-2020-038158 10.1371/journal.pone.0237458 10.1103/PhysRevE.70.046217 10.1007/bf01619355 10.1073/pnas.88.6.2297 10.1016/0165-0114(79)90020-4 10.1103/PhysRevE.71.021906 10.1002/j.1538-7305.1948.tb01338.x 10.1109/CIC.2002.1166726 10.1152/ajpheart.2000.278.6.H2039 10.1111/j.1749-6632.2001.tb02755.x 10.1152/ajpregu.00069.2002
Advances in Experimental Medicine and Biology; S G, Bacopoulou F et. al.

Jan 14th, 2022 - Heart rate variability (HRV) represents one of the two key markers of the autonomic nervous system. It is measured by the time variation in the beat-to-beat interval, while the period between successive beats is defined as the RR interval (RRI). Its components are classified as linear and non-linear. In the field of psychophysiology, HRV is investigated as a key player of possible predictive or...

Biomarkers and Precision Medicine in Alzheimer's Disease.
https://doi.org/10.1007/978-3-030-78787-5_50
Advances in Experimental Medicine and Biology; Sagar R, Pathak P et. al.

Jan 14th, 2022 - Alzheimer's disease (AD) is the most common form of dementia in the elderly, which is the fifth major cause of mortality for people over 65 years. While some of the hereditary genetic risk factors can be connected to the known amyloid and tau hypothesis, many treatments targeting this pathophysiology have failed in clinical trials or ineffectiveness of the drugs are attributed to the heterogene...

The Effect of Nutrients on Alzheimer's Disease Biomarkers: A Metabolomic Approach.
https://doi.org/10.1007/978-3-030-78787-5_35
Advances in Experimental Medicine and Biology; Kalli ΕG

Jan 14th, 2022 - A large number of plasma proteomic biomarkers have been discovered in the field of neurodegenerative diseases. Novel biomarker molecules in plasma and serum could significantly reduce the need for invasive methods in clinical practice such as the lumbar puncture for CSF collection and may be useful to specific patients. Furthermore, candidate biomarker proteins that have been identified and val...

Preimplantation Genetic Testing for Spastic Paraplegia Type 3.
https://doi.org/10.1007/978-3-030-78787-5_42 10.1097/00019052-199708000-00006 10.1001/jamaneurol.2013.1956 10.1007/s10048-019-00565-6 10.1002/mdc3.12184 10.1212/WNL.0b013e3181b04c6c 10.1055/s-0031-1299787 10.1002/pd.325 10.1038/sj.ejhg.5200871 10.1002/(SICI)1097-0223(199603)16:3<262::AID-PD841>3.0.CO;2-F 10.1007/978-3-030-32633-3_28 10.1038/s41467-019-08478-6 10.1186/1471-2377-10-89 10.1038/s41598-019-50911-9 10.1007/s00415-016-8179-z 10.1016/S0022-510X(03)00210-7
Advances in Experimental Medicine and Biology; Yapijakis C, Gintoni I et. al.

Jan 14th, 2022 - Spastic paraplegia type 3 (SPG3) is a common autosomal dominant neurogenetic disease, presenting during childhood with symptoms of mildly progressive spasticity and weakness of the lower limbs. SPG3 develops due to mutations of the ATL1 gene that encodes atlastin-1, a GTPase crucial for the function of dendrites of corticospinal neurons. Here we present a case of preimplantation genetic testing...

Developing Treatments for Alzheimer's and Related Disorders with Precision Medicine: A ...
https://doi.org/10.1007/978-3-030-78787-5_49 10.1016/s0140-6736(17)31363-6 10.1016/j.dadm.2019.02.006 10.1371/journal.pone.0204695 10.1016/j.jalz.2019.05.002 10.3233/jad-180619 10.1016/j.jagp.2013.12.175
Advances in Experimental Medicine and Biology; Avramopoulos D, Kapogiannis D et. al.

Jan 14th, 2022 - Precision medicine, also known as personalized medicine, is concerned with finding the right treatment for the right patient at the right time. It is a way of thinking focused on parsing heterogeneity ultimately down to the level of the individual. Its main mission is to identify characteristics of heterogeneous clinical conditions so as to target tailored therapies to individuals. Precision Me...

A retroperitoneal bronchogenic cyst clinically mimicking an adrenal mass: three case re...
https://doi.org/10.1177/03000605211072664
The Journal of International Medical Research; Hu BY, Yu H et. al.

Jan 14th, 2022 - Bronchogenic cysts are a congenital primitive foregut-derived developmental malformation, generally occurring in the posterior mediastinum. Their development in the retroperitoneum is extremely rare. Imaging techniques, such as multidetector computed tomography (MDCT), are typically effective in the detection of these lesions. Here, we describe three cases of a retroperitoneal cyst presenting a...

Improving screening and management of latent tuberculosis infection: development and ev...
https://doi.org/10.1186/s12879-021-06925-8 10.1183/13993003.00655-2019 10.1097/QCO.0000000000000253 10.1183/13993003.00840-2016 10.5694/mja16.00826 10.1186/1471-2458-9-141 10.5588/ijtld.12.0439 10.5694/j.1326-5377.2011.tb03108.x 10.5588/ijtld.14.0729 10.1016/S1473-3099(16)30216-X 10.1183/09031936.00214014 10.1136/thoraxjnl-2013-203805 10.1016/S0140-6736(07)60707-7 10.1186/s12879-015-1091-9 10.31128/AJGP-10-19-5139 10.1136/bmjqs-2015-004411 10.1038/npjpcrm.2016.78 10.1002/nur.21768 10.1007/s11135-017-0574-8 10.1378/chest.09-0394 10.1186/s12879-016-1549-4 10.1186/s12879-017-2245-8 10.1056/NEJMoa1714283
BMC Infectious Diseases; Kunin M, Timlin M et. al.

Jan 14th, 2022 - In Australia, demand for specialist infectious diseases services exceeds capacity to provide timely management of latent tuberculosis infection (LTBI) in areas of high refugee and asylum seeker settlement. A model for treating LTBI patients in primary care has been developed and piloted in a refugee-focused primary health service (Monash Health Refugee Health and Wellbeing [MHRHW]) and a univer...

Cutaneous Desmoplastic Leiomyosarcoma Development at Smallpox Vaccination Site.
https://www.ncbi.nlm.nih.gov/pubmed/35022120
Skinmed Patel MH, Brumfiel CM et. al.

Jan 14th, 2022 - An 81-year-old man presented to the clinic with a 2.1 cm firm, skin-colored subcutaneous tumor on the left upper arm (Figure 1). The lesion arose at the site of a past smallpox vaccination and had been slowly enlarging for approximately 4 years. The differential diagnosis included sympastic leiomyoma, and a variety of desmoplastic spindle cell lesions such as desmoplastic melanoma, cutaneous sp...

Anetoderma in a Patient with Newly Diagnosed Hodgkin's Lymphoma.
https://www.ncbi.nlm.nih.gov/pubmed/35022121
Skinmed Pateriya S, Tiwari N et. al.

Jan 14th, 2022 - A previously healthy 28-year-old woman was admitted to the hospital with respiratory failure and was found to have significant lymphadenopathy on her CT scan. A lymph node biopsy was performed; the pathology was consistent with a diagnosis of Hodgkin's lymphoma and the patient was noted to have multiple, wrinkled, nonscaly, oval-shaped papules that were easily compressible (Figure 1) and were p...

Diffuse Large B-Cell Lymphoma in the Setting of Chronic Lymphocytic Leukemia.
https://www.ncbi.nlm.nih.gov/pubmed/35022122
Skinmed Esteves M, Baudrier T et. al.

Jan 14th, 2022 - A 77-year-old man was referred to our department with a 6-month history of a painless, rapidly enlarging tumor on the left leg. Fourteen years ago, he was diagnosed with chronic lymphocytic leukemia (CLL), and he had presented with lymphocytosis and multiple lymphadenopathies (Rai stage II). Both bone marrow aspiration and peripheral blood immunophenotyping identified a monoclonal B-cell popula...

Correlations between rotational thromboelastometry (ROTEM) and standard coagulation tes...
https://doi.org/10.1177/03000605211067321
The Journal of International Medical Research; Dang XT, Nguyen TX et. al.

Jan 14th, 2022 - A high prevalence of venom-induced consumption coagulopathy has been reported in individuals with viper snakebites. Rotational thromboelastometry (ROTEM) is a rapid technique that could be advantageous in assessing and monitoring coagulation disorders. To explore correlations between ROTEM and standard coagulation tests. This prospective observational study was performed among 41 patients with ...