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Michael J. Morris, MD, on Prostate Cancer: Impact of PSMA-Targeted Imaging on Clinical Management
https://ascopost.com/videos/asco20-virtual-scientific-program/michael-morris-on-the-impact-of-psma-targeted-imaging-on-clinical-management-of-prostate-cancer/

Jun 1st, 2020 - Michael J. Morris, MD, of Memorial Sloan Kettering Cancer Center, discusses phase III data from the CONDOR trial, which showed that PSMA-targeted PET scans detected and localized occult disease in most men with biochemically recurrent prostate cancer presenting with negative or equivocal conventional imaging findings (Abstract 5501).

PyL PET Tracer May Be Superior to Standard Imaging for Prostate Cancer
https://www.targetedonc.com/view/pyl-pet-tracer-may-be-superior-to-standard-imaging-for-prostate-cancer

May 30th, 2020 - PSMA-targeted 18F-DCFPyL-PET/CT imaging demonstrated excellent diagnostic performance in men with biochemically relapsed prostate cancer in terms of a correct localization rate that far exceeded the criteria to meet the primary end point, according to findings from the phase 3 CONDOR trial.

Diagnostic Performance of PSMA-Targeted PET Tracer Excels in Relapsed Prostate Cancer
https://www.onclive.com/conference-coverage/asco-2020/diagnostic-performance-of-psma-targeted-pet-tracer-excels-in-relapsed-prostate-cancer

May 30th, 2020 - Imaging with 18F-DCFPyL-PET/CT outperformed that of standard imaging modalities—such as bone scan, CT, MRI, and FDG PET—in patients with biochemically relapsed prostate cancer in the phase 3 CONDOR trial.

PSMA-Targeted PET Tracer Outperforms Standard Diagnostic Modalities in Relapsed Prostate Cancer
https://www.targetedonc.com/view/psma-targeted-pet-tracer-outperforms-standard-diagnostic-modalities-in-relapsed-prostate-cancer

May 30th, 2020 - 18F-DCFPyL-PET/CT imaging outperfomed standard imaging modalities, including bone scan, CT, MRI, and FDG PET, in patients with biochemically relapsed prostate cancer, according to the phase 3 CONDOR study.

18F-DCFPyL–PET/CT Imaging Improves Diagnostic Capability in Relapsed Prostate Cancer
https://dailynews.ascopubs.org/do/10.1200/ADN.20.200168/full/

May 29th, 2020 - Imaging with 18F-DCFPyL–PET/CT was found to be diagnostically effective, often guiding a change in treatment plan, in men with biochemically relapsed prostate cancer, according to the results of the phase III CONDOR study presented during the ASCO20 Virtual Scientific Program (Abstract 5501).

National Institute of Biomedical Imaging and Bioengineering (NIBIB)
https://www.nibib.nih.gov/

The mission of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) is to improve health by leading the development and accelerating the application of biomedical technologies. The Institute is committed to integrating the physical and engineering sciences with the life sciences to advance basic research and medical care.

Improved Treatment Response Following Magnetic Resonance Imaging–Guided Focused Ultrasound for Lumbar Facet Joint Pain
https://www.sciencedirect.com/science/article/pii/S2542454819301535

Magnetic resonance imaging–guided focused ultrasound (MRgFUS) is a noninvasive modality that allows for precise tissue ablation with sparing of surrounding structures. Early reports of the use of MRgFUS for the treatment of facet joint osteoarthritis are promising. We present a case of facet joint pain treated successfully by MRgFUS at our institution. Magnetic resonance imaging–guided focused ...

Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection
https://jamanetwork.com/journals/jamacardiology/fullarticle/2770645

Myocarditis is a significant cause of sudden cardiac death in competitive athletes and can occur with normal ventricular function.1 Recent studies have raised concerns of myocardial inflammation after recovery from coronavirus disease 2019 (COVID-19), even in asymptomatic or mildly symptomatic patients.2 Our objective was to investigate the use of cardiac magnetic resonance (CMR) imaging in com...

Flow-metabolism dissociation in the pathogenesis of levodopa-induced dyskinesia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033758/

Levodopa-induced dyskinesia (LID) is the most common, disruptive complication of Parkinson’s disease (PD) pharmacotherapy, yet despite decades of research, the changes in regional brain function underlying LID remain largely unknown. We previously found that the cerebral vasomotor and metabolic responses to levodopa are dissociated in PD subjects. Nonetheless, it is unclear whether levodopa-med...

The serotonergic system in Parkinson’s patients with dyskinesia: evidence from imaging studies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060863/

The purpose of review is to review the current status of positron emission tomography (PET) molecular imaging of serotonergic system in Parkinson’s patients who experience levodopa-induced (LIDs) and graft-induced dyskinesias (GIDs). PET imaging studies have shown that Parkinson’s disease is characterized by progressive loss of dopaminergic and serotonergic neurons. Parkinson’s patients who exp...

Risk factors of levodopa-induced dyskinesia in Parkinson’s disease: results from the PPMI cohort
https://www.nature.com/articles/s41531-018-0069-x
NPJ Parkinson's Disease;

Levodopa-induced dyskinesias (LID) negatively impact on the quality of life of patients with Parkinson’s disease (PD). We assessed the risk factors for LID in a cohort of de-novo PD patients enrolled in the Parkinson’s Progression Markers Initiative (PPMI). This retrospective cohort study included all PD patients enrolled in the PPMI cohort. Main outcome was the incidence rate of dyskinesia, de...

Imaging in Parkinson’s disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280219/
Clinical Medicine;

The clinical presentation of Parkinson’s disease (PD) is heterogeneous and overlaps with other conditions, including the parkinsonian variant of multiple system atrophy (MSA-P), progressive supranuclear palsy (PSP) and essential tremor. Imaging of the brain in patients with parkinsonism has the ability to increase the accuracy of differential diagnosis. Magnetic resonance imaging (MRI), single ...

Dopamine Transporter Density in de novo Parkinson's Disease Does Not Relate to the Development of Levodopa-Induced Dyskinesias
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901354/

In Parkinson’s disease (PD), the onset of levodopa-induced dyskinesias (LIDs) is difficult to predict. This study examines whether dopamine transporter (DAT)-specific SPECT imaging in de novo PD relates to later development of LIDs.

Alcohol Intoxication and Cognition: Implications on Mechanisms and Therapeutic Strategies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029710/

Binge alcohol drinking is highly prevalent in young adults and results in 30% deaths per year in young males. Binge alcohol drinking or acute alcohol intoxication is a risk factor for developing alcohol use disorder (AUD). Three FDA approved drugs are currently in use as therapy for AUD; however, all of them have contra-indications and limitations. Structural brain imaging studies in alcoholics...

2019 Update of the American College of Rheumatology/Spondylitis Association of America/...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764882
Arthritis & Rheumatology (Hoboken, N.J.); Ward MM, Deodhar A et. al.

Aug 23rd, 2019 - To update evidence-based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA). We conducted updated systematic literature reviews for 20 clinical questions on pharmacologic treatment addressed in the 2015 guidelines, and for 26 new questions on pharmacologic treatment, treat-to-target strategy, and use of imaging. New q...

Innovative lung-imaging technique shows cause of long-COVID symptoms
https://news.westernu.ca/2022/06/innovative-lung-imaging-technique-shows-cause-of-long-covid-symptoms/
Western News; Mackay C.

Jun 28th, 2022 - Many who experience what is now called ‘long-COVID’ report feeling brain fog, breathless, fatigued and limited in doing everyday things, often lasting weeks and months post-infection. Using functional MRI with inhaled xenon gas, researchers at Western were one of the first to show that these debilitating symptoms are related to microscopic abnormalities that affect how oxygen is exchanged from ...

Highlighting COVID-19 Blood Clot Dangers
https://www.uspharmacist.com/article/highlighting-covid19-blood-clot-dangers

Based on recent reports that demonstrated a strong association between elevated D-dimer levels and poor prognosis, concerns have risen about thrombotic complications in patients with COVID-19. To address these concerns, the National Institute for Public Health of the Netherlands asked a group of radiology and vascular medicine experts to provide guidance for the imaging workup and treatment of ...

In silico Prediction of Deleterious Single Nucleotide Polymorphism in S100A4 Metastatic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357733
Contrast Media & Molecular Imaging; Farhana A, Kothandan S et. al.

Aug 16th, 2022 - S100A4 protein overexpression has been reported in different types of cancer and plays a key role by interacting with the tumor suppressor protein Tp53. Single nucleotide polymorphisms (SNP) in S100A4 could directly influence the biomolecular interaction with the tumor suppressor protein Tp53 due to their aberrant conformations. Hence, the study was designed to predict the deleterious SNP and i...

Toll-Like Receptor 4 Exacerbates Mycoplasma pneumoniaevia Promoting Transcription Facto...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357725
Contrast Media & Molecular Imaging; Liu Y, Li J et. al.

Aug 16th, 2022 - Mycoplasma pneumoniae (M. pneumoniae) is the most common cause of community-acquired pneumonia. Toll-like receptors (TLRs) play an essential role in pneumonia. The purpose of this study was to investigate the roles of TLR4 in M. pneumoniae. Mice were administrated with 100 μl (1 × 107 ccu/ml) of M. pneumoniae. HE staining was applied for histological analysis. The protein expression was determi...

Effects of the Combination of Continuous Nursing Care and Breathing Exercises on Respir...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357719
Contrast Media & Molecular Imaging; Du J

Aug 16th, 2022 - The purpose of this study was to explore the effect of respiratory function and self-efficacy of patients with lung cancer after surgery by the combination of continuing nursing care and breathing exercises and to assess its clinical value in improving the quality of patients' sleep. 120 cases of lung cancer patients were divided into the control group (n = 60 cases) and the experimental group ...