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About 13 results

Mersana's Cancer Drug Trial Put on Hold by FDA; Shares Halted
https://emedicine.medscape.com/viewarticle/899552

PRECISION: Differences Emerge Between RA and OA Patients
https://emedicine.medscape.com/viewarticle/871988

WASHINGTON, DC — Rates of all-cause mortality are significantly higher when patients with rheumatoid arthritis are treated with naproxen than when they are treated with ibuprofen or the selective cyclooxygenase (COX)-2 inhibitor celecoxib (Celebrex, Pfizer), according to a subanalysis of data from the PRECISION trial. However, this increase does not apply to patients with osteoarthritis. The PR...

Options Unfairly Limited for Off-Label Medicare Dermatology Treatments
https://emedicine.medscape.com/viewarticle/908496

NEW YORK (Reuters Health) - Compendia used to make coverage determinations for off-label prescribing in dermatology are "incomplete, outdated, idiosyncratic, and unpredictable," researchers say. Medicare Part D uses two compendia when making coverage determinations: the American Hospital Formulary Service (AHFS) and DRUGDEX. However, these compendia have "deficiencies" with regard to accuracy a...

Pembro Plus Chemo: Practice-Changing for mNSCLC
https://emedicine.medscape.com/viewarticle/895270

CHICAGO — Patients with nonsquamous metastatic non-small cell lung carcinoma (NSCLC) lived significantly longer and had a 48% reduced risk for disease progression if they received pembrolizumab (Keytruda, Merck) in addition to chemotherapy compared with those who received standard chemotherapy alone.   These data for overall survival (OS) and progression-free survival (PFS) from the  KEYNOTE-18...

Low-Dose Prostate Drug Can Match Standard Dose, Cut Costs
https://emedicine.medscape.com/viewarticle/895350

Giving patients with metastatic castration-resistant prostate cancer (CRPC) just one quarter of the normal dose of abiraterone acetate (AA) (Zytiga, Janssen) with food achieves at least as great a reduction in prostate-specific antigen (PSA) levels as the standard dose without food, the results of a prospective, randomized trial reveal. AA, which is a standard of care in CRPC, was administered ...

Maculopathy Common With Long-Term Pentosan Polysulfate Therapy
https://emedicine.medscape.com/viewarticle/924381

NEW YORK (Reuters Health) - Long-term use of pentosan polysulfate sodium, the only oral medicine approved for interstitial cystitis, is associated with development of a unique pigmentary maculopathy, researchers report. "All patients who take Elmiron (pentosan polysulfate) should be seen by a retina specialist," Dr. Robin A. Vora, an ophthalmologist with Kaiser Permanente Northern California (K...

Specialist Perspectives on SLE Management: Approaches to Integrating Care
https://emedicine.medscape.com/viewarticle/907891

Transcranial DC Stimulation Promising in Bipolar Depression
https://emedicine.medscape.com/viewarticle/891000

Transcranial direct current stimulation (tDCS) was effective, safe, and well tolerated as add-on treatment for bipolar depression in the first randomized sham-controlled double-blind study of tDCS in bipolar depression. Compared with sham tDCS, active tDCS was associated with superior improvement in depressive symptoms and did not induce more manic/hypomanic episodes, the investigators report. ...

U.S. Group Says Novartis MS Drug Price Out of Line With Benefit
https://emedicine.medscape.com/viewarticle/914719

ZURICH (Reuters) - A U.S. group that reviews the value of medicines issued a critical report on Novartis's new multiple sclerosis drug Mayzent (siponimod), calling its $88,561 list price "far out of line" compared with its benefits for patients. The Boston-based Institute for Clinical and Economic Review (ICER), which has been reviewing Mayzent for months, recommended that Novartis lower the dr...

Clearing the Patient on Bisphosphonates for Dental Procedures: When Should You Do It?
https://emedicine.medscape.com/viewarticle/883371

Case Presentation Image from iStock A 66-year-old woman who began treatment with alendronate 6 months ago for osteoporosis presents to your office for medical clearance prior to dental work.

Oral Fluoroquinolones Carry Small Risk of Peripheral Neuropathy
https://emedicine.medscape.com/viewarticle/912496

NEW YORK (Reuters Health) - Oral fluoroquinolone exposure is associated with a small increase in risk of peripheral neuropathy, according to findings from The Health Improvement Network (THIN) database. "Peripheral neuropathy is one of several side effects that may occur following fluoroquinolone therapy, and other antibiotics have side effects, too," Dr. Daniel Morales of the University of Dun...

Maternal Anti-HBVs Suppress the Immune Response of Infants to Hepatitis B Vaccine
https://emedicine.medscape.com/viewarticle/872460

Abstract and Introduction Abstract It is still controversial whether maternal anti-HBV antibodies (anti-HBVs) affect the infants' immune response to hepatitis B virus (HBV) vaccination. This multicentre study aims to address this question. First, we determined whether the transplacental transfer of maternal anti-HBVs occurs by measuring the titres of 90 anti-HBVs-positive pregnant women and the...

Best Practices for Reducing Unplanned Acute Care for Patients With Cancer
https://emedicine.medscape.com/viewarticle/897000

Abstract and Introduction Abstract Variation and cost in oncology care represent a large and growing burden for the US health care system, and acute hospital care is one of the single largest drivers. Reduction of unplanned acute care is a major priority for clinical transformation in oncology; proposed changes to Medicare reimbursement for patients with cancer who suffer unplanned admissions w...