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About 189,630 results

Screening for cognitive impairment in older adults: U.S. Preventive Services Task Force...
https://doi.org/10.7326/M14-0496
Annals of Internal Medicine; Moyer VA,

Mar 25th, 2014 - Update of the 2003 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for dementia. The USPSTF reviewed the evidence on the benefits, harms, and sensitivity and specificity of screening instruments for cognitive impairment in older adults and the benefits and harms of commonly used treatment and management options for older adults with mild cognitive impairment or early de...

Use of Vibrio cholerae vaccine in an outbreak in Guinea.
https://doi.org/10.1056/NEJMoa1312680
The New England Journal of Medicine; Luquero FJ, Grout L et. al.

May 29th, 2014 - The use of vaccines to prevent and control cholera is currently under debate. Shanchol is one of the two oral cholera vaccines prequalified by the World Health Organization; however, its effectiveness under field conditions and the protection it confers in the first months after administration remain unknown. The main objective of this study was to estimate the short-term effectiveness of two d...

Health and economic benefits of early vaccination and nonpharmaceutical interventions f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053659
Annals of Internal Medicine; Khazeni N, Hutton DW et. al.

May 20th, 2014 - Vaccination for the 2009 pandemic did not occur until late in the outbreak, which limited its benefits. Influenza A (H7N9) is causing increasing morbidity and mortality in China, and researchers have modified the A (H5N1) virus to transmit via aerosol, which again heightens concerns about pandemic influenza preparedness. To determine how quickly vaccination should be completed to reduce infecti...

Circumcision rates in the United States: rising or falling? What effect might the new a...
https://doi.org/10.1016/j.mayocp.2014.01.001
Mayo Clinic Proceedings; Morris BJ, Bailis SA et. al.

Apr 7th, 2014 - The objective of this review was to assess the trend in the US male circumcision rate and the impact that the affirmative 2012 American Academy of Pediatrics policy statement might have on neonatal circumcision practice. We searched PubMed for the term circumcision to retrieve relevant articles. This review was prompted by a recent report by the Centers for Disease Control and Prevention that f...

The changing face of heroin use in the United States: a retrospective analysis of the p...
https://doi.org/10.1001/jamapsychiatry.2014.366
JAMA Psychiatry; Cicero TJ, Ellis MS et. al.

May 29th, 2014 - Over the past several years, there have been a number of mainstream media reports that the abuse of heroin has migrated from low-income urban areas with large minority populations to more affluent suburban and rural areas with primarily white populations. To examine the veracity of these anecdotal reports and define the relationship between the abuse of prescription opioids and the abuse of her...

Screening pelvic examination in adult women: a clinical practice guideline from the Ame...
https://doi.org/10.7326/M14-0701
Annals of Internal Medicine; Qaseem A, Humphrey LL et. al.

Jun 30th, 2014 - The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on the utility of screening pelvic examination for the detection of pathology in asymptomatic, nonpregnant, adult women. This guideline is based on a systematic review of the published literature in the English language from 1946 through January 2014 identified using ME...

Should colorectal cancer screening be considered in elderly persons without previous sc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109030
Annals of Internal Medicine; van Hees F, Habbema JD et. al.

Jun 2nd, 2014 - The U.S. Preventive Services Task Force recommends against routine screening for colorectal cancer (CRC) in adequately screened persons older than 75 years but does not address the appropriateness of screening in elderly persons without previous screening. To determine at what ages CRC screening should be considered in unscreened elderly persons and to determine which test is indicated at each ...

Readmissions among children previously hospitalized with pneumonia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531280
Pediatrics Neuman MI, Hall M et. al.

Jun 24th, 2014 - Pneumonia is a leading cause of hospitalization and readmission in children. Understanding the patient characteristics associated with pneumonia readmissions is necessary to inform interventions to reduce avoidable hospitalizations and related costs. The objective of this study was to characterize readmission rates, and identify factors and costs associated with readmission among children previ...

Sustained care intervention and postdischarge smoking cessation among hospitalized adul...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507269
JAMA Rigotti NA, Regan S et. al.

Aug 20th, 2014 - Health care systems need effective models to manage chronic diseases like tobacco dependence across transitions in care. Hospitalizations provide opportunities for smokers to quit, but research suggests that hospital-delivered interventions are effective only if treatment continues after discharge. To determine whether an intervention to sustain tobacco treatment after hospital discharge increa...

Cancer screening rates in individuals with different life expectancies.
https://doi.org/10.1001/jamainternmed.2014.3895
JAMA Internal Medicine; Royce TJ, Hendrix LH et. al.

Aug 18th, 2014 - Routine cancer screening has unproven net benefit for patients with limited life expectancy. To examine the patterns of prostate, breast, cervical, and colorectal cancer screening in the United States in individuals with different life expectancies. Data from the population-based National Health Interview Survey (NHIS) from 2000 through 2010 were used and included 27 404 participants aged 65 ye...

The preventive surgical site infection bundle in colorectal surgery: an effective appro...
https://doi.org/10.1001/jamasurg.2014.346
JAMA Surgery; Keenan JE, Speicher PJ et. al.

Aug 27th, 2014 - Surgical site infections (SSIs) in colorectal surgery are associated with increased morbidity and health care costs. To determine the effect of a preventive SSI bundle (hereafter bundle) on SSI rates and costs in colorectal surgery. Retrospective study of institutional clinical and cost data. The study period was January 1, 2008, to December 31, 2012, and outcomes were assessed and compared bef...

Effect of enhanced information, values clarification, and removal of financial barriers...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445462
JAMA Kuppermann M, Pena S et. al.

Sep 23rd, 2014 - Prenatal genetic testing guidelines recommend providing patients with detailed information to allow informed, preference-based screening and diagnostic testing decisions. The effect of implementing these guidelines is not well understood. To analyze the effect of a decision-support guide and elimination of financial barriers to testing on use of prenatal genetic testing and decision making amon...

Comparative effectiveness of generic and brand-name statins on patient outcomes: a coho...
https://doi.org/10.7326/M13-2942
Annals of Internal Medicine; Gagne JJ, Choudhry NK et. al.

Sep 15th, 2014 - Statins are effective in preventing cardiovascular events, but patients do not fully adhere to them. To determine whether patients are more adherent to generic statins versus brand-name statins (lovastatin, pravastatin, or simvastatin) and whether greater adherence improves health outcomes. Observational, propensity score-matched, new-user cohort study. Linked electronic data from medical and p...

Use of medications of questionable benefit in advanced dementia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689196
JAMA Internal Medicine; Tjia J, Briesacher BA et. al.

Sep 9th, 2014 - Advanced dementia is characterized by severe cognitive impairment and complete functional dependence. Patients' goals of care should guide the prescribing of medication during such terminal illness. Medications that do not promote the primary goal of care should be minimized. To estimate the prevalence of medications with questionable benefit used by nursing home residents with advanced dementi...

Provision of no-cost, long-acting contraception and teenage pregnancy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230891
The New England Journal of Medicine; Secura GM, Madden T et. al.

Oct 1st, 2014 - The rate of teenage pregnancy in the United States is higher than in other developed nations. Teenage births result in substantial costs, including public assistance, health care costs, and income losses due to lower educational attainment and reduced earning potential. The Contraceptive CHOICE Project was a large prospective cohort study designed to promote the use of long-acting, reversible c...

Vaginal vs. robotic hysterectomy for patients with endometrial cancer: A comparison of ...
https://doi.org/10.1016/j.ygyno.2017.03.002
Gynecologic Oncology; Nitschmann CC, Multinu F et. al.

Apr 10th, 2017 - To compare outcomes and cost for patients with endometrial cancer undergoing vaginal hysterectomy (VH) or robotic hysterectomy (RH), with or without lymphadenectomy (LND). Patients undergoing planned VH (and laparoscopic LND) or RH (and robotic LND) between January 2007 and November 2012 were reviewed. Patients with stage IV disease, synchronous cancer, synchronous surgery, or treated with pall...

Economic return from the Women's Health Initiative estrogen plus progestin clinical tri...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157355
Annals of Internal Medicine; Roth JA, Etzioni R et. al.

May 6th, 2014 - The findings of the Women's Health Initiative (WHI) estrogen plus progestin (E+P) trial led to a substantial reduction in use of combined hormone therapy (cHT) among postmenopausal women in the United States. The economic effect of this shift has not been evaluated relative to the trial's $260 million cost (2012 U.S. dollars). To estimate the economic return from the WHI E+P trial. Decision mod...

Cost-effectiveness of novel regimens for the treatment of hepatitis C virus.
https://doi.org/10.7326/M14-1152
Annals of Internal Medicine; Najafzadeh M, Andersson K et. al.

Mar 16th, 2015 - New regimens for hepatitis C virus (HCV) have shorter treatment durations and increased rates of sustained virologic response compared with existing therapies but are extremely expensive. To evaluate the cost-effectiveness of these treatments under different assumptions about their price and efficacy. Discrete-event simulation. Published literature. Treatment-naive patients infected with chroni...

Cost-effectiveness and budget impact of hepatitis C virus treatment with sofosbuvir and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435698
Annals of Internal Medicine; Chhatwal J, Kanwal F et. al.

Mar 16th, 2015 - Sofosbuvir and ledipasvir, which have recently been approved for treatment of chronic hepatitis C virus (HCV) infection, are more efficacious and safer than the old standard of care (oSOC) but are substantially more expensive. Whether and in which patients their improved efficacy justifies their increased cost is unclear. To evaluate the cost-effectiveness and budget impact of sofosbuvir and le...

Effect of an enhanced medical home on serious illness and cost of care among high-risk ...
https://doi.org/10.1001/jama.2014.16419
JAMA Mosquera RA, Avritscher EB et. al.

Dec 23rd, 2014 - Patient-centered medical homes have not been shown to reduce adverse outcomes or costs in adults or children with chronic illness. To assess whether an enhanced medical home providing comprehensive care prevents serious illness (death, intensive care unit [ICU] admission, or hospital stay >7 days) and/or reduces costs among children with chronic illness. Randomized clinical trial of high-risk c...