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About 58,923 results

Inheritance of paternal DNA damage by histone-mediated repair restriction.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834056
Nature Wang S, Meyer DH et. al.

Dec 22nd, 2022 - How paternal exposure to ionizing radiation affects genetic inheritance and disease risk in the offspring has been a long-standing question in radiation biology. In humans, nearly 80% of transmitted mutations arise in the paternal germline1, but the transgenerational effects of ionizing radiation exposure has remained controversial and the mechanisms are unknown. Here we show that in sex-separa...

Primate gastrulation and early organogenesis at single-cell resolution.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771819
Nature Zhai J, Guo J et. al.

Dec 15th, 2022 - Our understanding of human early development is severely hampered by limited access to embryonic tissues. Due to their close evolutionary relationship with humans, nonhuman primates are often used as surrogates to understand human development but currently suffer from a lack of in vivo datasets, especially from gastrulation to early organogenesis during which the major embryonic cell types are ...

Periodic inhibition of Erk activity drives sequential somite segmentation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846577
Nature Simsek MF, Chandel AS et. al.

Dec 15th, 2022 - Sequential segmentation creates modular body plans of diverse metazoan embryos1-4. Somitogenesis establishes the segmental pattern of the vertebrate body axis. A molecular segmentation clock in the presomitic mesoderm sets the pace of somite formation4. However, how cells are primed to form a segment boundary at a specific location remains unclear. Here we developed precise reporters for the cl...

Conserved roles for Hnf4 family transcription factors in zebrafish development and inte...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713462
Genetics Heppert JK, Lickwar CR et. al.

Oct 12th, 2022 - Transcription factors play important roles in the development of the intestinal epithelium and its ability to respond to endocrine, nutritional, and microbial signals. Hepatocyte nuclear factor 4 family nuclear receptors are liganded transcription factors that are critical for the development and function of multiple digestive organs in vertebrates, including the intestinal epithelium. Zebrafis...

Failure of human rhombic lip differentiation underlies medulloblastoma formation.
https://doi.org/10.1038/s41586-022-05215-w
Nature Hendrikse LD, Haldipur P et. al.

Sep 22nd, 2022 - Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain1-4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage5-8. By contrast, mutations that activate WNT signalling lead to WNT MB in the lower RL9,10. However, littl...

A cellular hierarchy in melanoma uncouples growth and metastasis.
https://doi.org/10.1038/s41586-022-05242-7
Nature Karras P, Bordeu I et. al.

Sep 22nd, 2022 - Although melanoma is notorious for its high degree of heterogeneity and plasticity1,2, the origin and magnitude of cell-state diversity remains poorly understood. Equally, it is unclear whether growth and metastatic dissemination are supported by overlapping or distinct melanoma subpopulations. Here, by combining mouse genetics, single-cell and spatial transcriptomics, lineage tracing and quant...

Unified rhombic lip origins of group 3 and group 4 medulloblastoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748853
Nature Smith KS, Bihannic L et. al.

Sep 22nd, 2022 - Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into biologically distinct subgroups, suggesting that a personalized approach to therapy would be beneficial1. Mouse modelling and cross-species genomics have provided increasing evidence of discrete, subgroup-specific developmental origins2. However, the anatomical and cellular complexity of developing human tissu...

Wide-ranging migration and destination of early olfactory placode-derived neurons in ch...
https://doi.org/10.1002/ar.25080
Anatomical Record (Hoboken, N.J. : 2007); Miyakawa M, Murakmai S et. al.

Sep 16th, 2022 - Cell migration from the olfactory placode (OP) is a well-known phenomenon wherein various cell types, such as gonadotropin-releasing hormone (GnRH)-producing neurons, migrate toward the telencephalon (TEL) during early embryonic development. However, the spatial relationship between early migratory cells and the forebrain is unclear. We examined the early development of whole-mount chick embryo...

Glucose-driven TOR-FIE-PRC2 signalling controls plant development.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530021
Nature Ye R, Wang M et. al.

Sep 15th, 2022 - Nutrients and energy have emerged as central modulators of developmental programmes in plants and animals1-3. The evolutionarily conserved target of rapamycin (TOR) kinase is a master integrator of nutrient and energy signalling that controls growth. Despite its key regulatory roles in translation, proliferation, metabolism and autophagy2-5, little is known about how TOR shapes developmental tr...

Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cort...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481465
Nature Cell Biology; Bao M, Cornwall-Scoones J et. al.

Sep 14th, 2022 - Mammalian embryos sequentially differentiate into trophectoderm and an inner cell mass, the latter of which differentiates into primitive endoderm and epiblast. Trophoblast stem (TS), extraembryonic endoderm (XEN) and embryonic stem (ES) cells derived from these three lineages can self-assemble into synthetic embryos, but the mechanisms remain unknown. Here, we show that a stem cell-specific ca...

A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia e...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499540
Proceedings of the National Academy of Sciences of the Un... Wang L, Park JY et. al.

Sep 13th, 2022 - The neocortex, the center for higher brain function, first emerged in mammals and has become massively expanded and folded in humans, constituting almost half the volume of the human brain. Primary microcephaly, a developmental disorder in which the brain is smaller than normal at birth, results mainly from there being fewer neurons in the neocortex because of defects in neural progenitor cells...

ISL1 is necessary for auditory neuron development and contributes toward tonotopic orga...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478650
Proceedings of the National Academy of Sciences of the Un... Filova I, Pysanenko K et. al.

Sep 9th, 2022 - A cardinal feature of the auditory pathway is frequency selectivity, represented in a tonotopic map from the cochlea to the cortex. The molecular determinants of the auditory frequency map are unknown. Here, we discovered that the transcription factor ISL1 regulates the molecular and cellular features of auditory neurons, including the formation of the spiral ganglion and peripheral and central...

Tagged actin mRNA dysregulation in IGF2BP1Formula: see text mice.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477413
Proceedings of the National Academy of Sciences of the Un... Núñez L, Buxbaum AR et. al.

Sep 7th, 2022 - Gene expression is tightly regulated by RNA-binding proteins (RBPs) to facilitate cell survival, differentiation, and migration. Previous reports have shown the importance of the Insulin-like Growth Factor II mRNA-Binding Protein (IGF2BP1/IMP1/ZBP1) in regulating RNA fate, including localization, transport, and translation. Here, we generated and characterized a knockout mouse to study RBP regu...

Specific contribution of Reelin expressed by Cajal-Retzius cells or GABAergic interneur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477240
Proceedings of the National Academy of Sciences of the Un... Vílchez-Acosta A, Manso Y et. al.

Sep 7th, 2022 - The extracellular protein Reelin, expressed by Cajal-Retzius (CR) cells at early stages of cortical development and at late stages by GABAergic interneurons, regulates radial migration and the "inside-out" pattern of positioning. Current models of Reelin functions in corticogenesis focus on early CR cell-derived Reelin in layer I. However, developmental disorders linked to Reelin deficits, such...

Embryo model completes gastrulation to neurulation and organogenesis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534772
Nature Amadei G, Handford CE et. al.

Aug 26th, 2022 - Embryonic stem (ES) cells can undergo many aspects of mammalian embryogenesis in vitro1-5, but their developmental potential is substantially extended by interactions with extraembryonic stem cells, including trophoblast stem (TS) cells, extraembryonic endoderm stem (XEN) cells and inducible XEN (iXEN) cells6-11. Here we assembled stem cell-derived embryos in vitro from mouse ES cells, TS cells...

Regulators of early maize leaf development inferred from transcriptomes of laser captur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436337
Proceedings of the National Academy of Sciences of the Un... Liu WY, Yu CP et. al.

Aug 25th, 2022 - The superior photosynthetic efficiency of C4 leaves over C3 leaves is owing to their unique Kranz anatomy, in which the vein is surrounded by one layer of bundle sheath (BS) cells and one layer of mesophyll (M) cells. Kranz anatomy development starts from three contiguous ground meristem (GM) cells, but its regulators and underlying molecular mechanism are largely unknown. To identify the regul...

A condensate dynamic instability orchestrates actomyosin cortex activation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477739
Nature Yan VT, Narayanan A et. al.

Aug 18th, 2022 - A key event at the onset of development is the activation of a contractile actomyosin cortex during the oocyte-to-embryo transition1-3. Here we report on the discovery that, in Caenorhabditis elegans oocytes, actomyosin cortex activation is supported by the emergence of thousands of short-lived protein condensates rich in F-actin, N-WASP and the ARP2/3 complex4-8 that form an active micro-emuls...

The developing bird pelvis passes through ancestral dinosaurian conditions.
https://doi.org/10.1038/s41586-022-04982-w
Nature Griffin CT, Botelho JF et. al.

Jul 28th, 2022 - Living birds (Aves) have bodies substantially modified from the ancestral reptilian condition. The avian pelvis in particular experienced major changes during the transition from early archosaurs to living birds1,2. This stepwise transformation is well documented by an excellent fossil record2-4; however, the ontogenetic alterations that underly it are less well understood. We used embryologica...

Dynamic regulation and requirement for ribosomal RNA transcription during mammalian dev...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351356
Proceedings of the National Academy of Sciences of the Un... Falcon KT, Watt KEN et. al.

Jul 27th, 2022 - Ribosomal RNA (rRNA) transcription by RNA polymerase I (Pol I) is a critical rate-limiting step in ribosome biogenesis, which is essential for cell survival. Despite its global function, disruptions in ribosome biogenesis cause tissue-specific birth defects called ribosomopathies, which frequently affect craniofacial development. Here, we describe a cellular and molecular mechanism underlying t...

Sox8 remodels the cranial ectoderm to generate the ear.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282420
Proceedings of the National Academy of Sciences of the Un... Buzzi AL, Chen J et. al.

Jul 23rd, 2022 - The vertebrate inner ear arises from a pool of progenitors with the potential to contribute to all the sense organs and cranial ganglia in the head. Here, we explore the molecular mechanisms that control ear specification from these precursors. Using a multiomics approach combined with loss-of-function experiments, we identify a core transcriptional circuit that imparts ear identity, along with...