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About 58,865 results

A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia e...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499540
Proceedings of the National Academy of Sciences of the Un... Wang L, Park JY et. al.

Sep 13th, 2022 - The neocortex, the center for higher brain function, first emerged in mammals and has become massively expanded and folded in humans, constituting almost half the volume of the human brain. Primary microcephaly, a developmental disorder in which the brain is smaller than normal at birth, results mainly from there being fewer neurons in the neocortex because of defects in neural progenitor cells...

ISL1 is necessary for auditory neuron development and contributes toward tonotopic orga...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478650
Proceedings of the National Academy of Sciences of the Un... Filova I, Pysanenko K et. al.

Sep 9th, 2022 - A cardinal feature of the auditory pathway is frequency selectivity, represented in a tonotopic map from the cochlea to the cortex. The molecular determinants of the auditory frequency map are unknown. Here, we discovered that the transcription factor ISL1 regulates the molecular and cellular features of auditory neurons, including the formation of the spiral ganglion and peripheral and central...

Tagged actin mRNA dysregulation in IGF2BP1Formula: see text mice.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477413
Proceedings of the National Academy of Sciences of the Un... Núñez L, Buxbaum AR et. al.

Sep 7th, 2022 - Gene expression is tightly regulated by RNA-binding proteins (RBPs) to facilitate cell survival, differentiation, and migration. Previous reports have shown the importance of the Insulin-like Growth Factor II mRNA-Binding Protein (IGF2BP1/IMP1/ZBP1) in regulating RNA fate, including localization, transport, and translation. Here, we generated and characterized a knockout mouse to study RBP regu...

Specific contribution of Reelin expressed by Cajal-Retzius cells or GABAergic interneur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477240
Proceedings of the National Academy of Sciences of the Un... Vílchez-Acosta A, Manso Y et. al.

Sep 7th, 2022 - The extracellular protein Reelin, expressed by Cajal-Retzius (CR) cells at early stages of cortical development and at late stages by GABAergic interneurons, regulates radial migration and the "inside-out" pattern of positioning. Current models of Reelin functions in corticogenesis focus on early CR cell-derived Reelin in layer I. However, developmental disorders linked to Reelin deficits, such...

Regulators of early maize leaf development inferred from transcriptomes of laser captur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436337
Proceedings of the National Academy of Sciences of the Un... Liu WY, Yu CP et. al.

Aug 25th, 2022 - The superior photosynthetic efficiency of C4 leaves over C3 leaves is owing to their unique Kranz anatomy, in which the vein is surrounded by one layer of bundle sheath (BS) cells and one layer of mesophyll (M) cells. Kranz anatomy development starts from three contiguous ground meristem (GM) cells, but its regulators and underlying molecular mechanism are largely unknown. To identify the regul...

A condensate dynamic instability orchestrates actomyosin cortex activation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477739
Nature Yan VT, Narayanan A et. al.

Aug 18th, 2022 - A key event at the onset of development is the activation of a contractile actomyosin cortex during the oocyte-to-embryo transition1-3. Here we report on the discovery that, in Caenorhabditis elegans oocytes, actomyosin cortex activation is supported by the emergence of thousands of short-lived protein condensates rich in F-actin, N-WASP and the ARP2/3 complex4-8 that form an active micro-emuls...

The developing bird pelvis passes through ancestral dinosaurian conditions.
https://doi.org/10.1038/s41586-022-04982-w
Nature Griffin CT, Botelho JF et. al.

Jul 28th, 2022 - Living birds (Aves) have bodies substantially modified from the ancestral reptilian condition. The avian pelvis in particular experienced major changes during the transition from early archosaurs to living birds1,2. This stepwise transformation is well documented by an excellent fossil record2-4; however, the ontogenetic alterations that underly it are less well understood. We used embryologica...

Dynamic regulation and requirement for ribosomal RNA transcription during mammalian dev...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351356
Proceedings of the National Academy of Sciences of the Un... Falcon KT, Watt KEN et. al.

Jul 27th, 2022 - Ribosomal RNA (rRNA) transcription by RNA polymerase I (Pol I) is a critical rate-limiting step in ribosome biogenesis, which is essential for cell survival. Despite its global function, disruptions in ribosome biogenesis cause tissue-specific birth defects called ribosomopathies, which frequently affect craniofacial development. Here, we describe a cellular and molecular mechanism underlying t...

Sox8 remodels the cranial ectoderm to generate the ear.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282420
Proceedings of the National Academy of Sciences of the Un... Buzzi AL, Chen J et. al.

Jul 23rd, 2022 - The vertebrate inner ear arises from a pool of progenitors with the potential to contribute to all the sense organs and cranial ganglia in the head. Here, we explore the molecular mechanisms that control ear specification from these precursors. Using a multiomics approach combined with loss-of-function experiments, we identify a core transcriptional circuit that imparts ear identity, along with...

Differential expression profile and in-silico functional analysis of long noncoding RNA...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281093
BMC Genomics; Wu Z, Zeng Y et. al.

Jul 15th, 2022 - Duck plague virus (DPV), belonging to herpesviruses, is a linear double-stranded DNA virus. There are many reports about the outbreak of the duck plague in a variety of countries, which caused huge economic losses. Recently, increasing reports revealed that multiple long non-coding RNAs (lncRNAs) can possess great potential in the regulation of host antiviral immune response. Furthermore, it re...

Single-cell roadmap of human gonadal development.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300467
Nature Garcia-Alonso L, Lorenzi V et. al.

Jul 7th, 2022 - Gonadal development is a complex process that involves sex determination followed by divergent maturation into either testes or ovaries1. Historically, limited tissue accessibility, a lack of reliable in vitro models and critical differences between humans and mice have hampered our knowledge of human gonadogenesis, despite its importance in gonadal conditions and infertility. Here, we generate...

Multiomic atlas with functional stratification and developmental dynamics of zebrafish ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279159
Nature Genetics; Baranasic D, Hörtenhuber M et. al.

Jul 6th, 2022 - Zebrafish, a popular organism for studying embryonic development and for modeling human diseases, has so far lacked a systematic functional annotation program akin to those in other animal models. To address this, we formed the international DANIO-CODE consortium and created a central repository to store and process zebrafish developmental functional genomic data. Our data coordination center (...

Distinct gene expression dynamics in developing and regenerating crustacean limbs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271199
Proceedings of the National Academy of Sciences of the Un... Sinigaglia C, Almazán A et. al.

Jul 2nd, 2022 - Regenerating animals have the ability to reproduce body parts that were originally made in the embryo and subsequently lost due to injury. Understanding whether regeneration mirrors development is an open question in most regenerative species. Here, we take a transcriptomics approach to examine whether leg regeneration shows similar temporal patterns of gene expression as leg development in the...

Latent space of a small genetic network: Geometry of dynamics and information.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245618
Proceedings of the National Academy of Sciences of the Un... Seyboldt R, Lavoie J et. al.

Jun 24th, 2022 - The high-dimensional character of most biological systems presents genuine challenges for modeling and prediction. Here we propose a neural network-based approach for dimensionality reduction and analysis of biological gene expression data, using, as a case study, a well-known genetic network in the early Drosophila embryo, the gap gene patterning system. We build an autoencoder compressing the...

Temporal control of late replication and coordination of origin firing by self-stabiliz...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245680
Proceedings of the National Academy of Sciences of the Un... Cho CY, Seller CA et. al.

Jun 24th, 2022 - In the metazoan S phase, coordinated firing of clusters of origins replicates different parts of the genome in a temporal program. Despite advances, neither the mechanism controlling timing nor that coordinating firing of multiple origins is fully understood. Rif1, an evolutionarily conserved inhibitor of DNA replication, recruits protein phosphatase 1 (PP1) and counteracts firing of origins by...

Spatial profiling of early primate gastrulation in utero.
https://doi.org/10.1038/s41586-022-04953-1
Nature Bergmann S, Penfold CA et. al.

Jun 17th, 2022 - Gastrulation controls the emergence of cellular diversity and axis patterning in the early embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the interface of embryonic and extraembryonic tissues1-3. Elucidating the molecular framework of axis formation in vivo is fundamental for our understanding of human development4-6 and to advance stem-cell-based regen...

Alterations in cardiac output in fetuses with congenital heart disease.
https://doi.org/10.1002/pd.6193
Prenatal Diagnosis; Sethi N, Gai J et. al.

Jun 15th, 2022 - Fetuses with severe congenital heart disease (CHD) have altered blood flow patterns. Prior work to assess fetal combined cardiac output (CCO) is limited by sample size and lack of longitudinal gestational data. Our aim was to evaluate CCO in CHD fetuses to determine whether the presence of single ventricle (SV) physiology or aortic obstruction impacts fetal blood flow and cardiovascular hemodyn...

Fmr1 exon 14 skipping in late embryonic development of the rat forebrain.
https://doi.org/10.1186/s12868-022-00711-1
BMC Neuroscience; Corrêa-Velloso JC, Linardi AM et. al.

Jun 2nd, 2022 - Fragile X syndrome, the major cause of inherited intellectual disability among men, is due to deficiency of the synaptic functional regulator FMR1 protein (FMRP), encoded by the FMRP translational regulator 1 (FMR1) gene. FMR1 alternative splicing produces distinct transcripts that may consequently impact FMRP functional roles. In transcripts without exon 14 the translational reading frame is s...

Thalamocortical axons regulate neurogenesis and laminar fates in the early sensory cortex.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295754
Proceedings of the National Academy of Sciences of the Un... Monko T, Rebertus J et. al.

May 26th, 2022 - Area-specific axonal projections from the mammalian thalamus shape unique cellular organization in target areas in the adult neocortex. How these axons control neurogenesis and early neuronal fate specification is poorly understood. By using mutant mice lacking the majority of thalamocortical axons, we show that these axons are required for the production and specification of the proper number ...

Gibbin mesodermal regulation patterns epithelial development.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202145
Nature Collier A, Liu A et. al.

May 19th, 2022 - Proper ectodermal patterning during human development requires previously identified transcription factors such as GATA3 and p63, as well as positional signalling from regional mesoderm1-6. However, the mechanism by which ectoderm and mesoderm factors act to stably pattern gene expression and lineage commitment remains unclear. Here we identify the protein Gibbin, encoded by the Xia-Gibbs AT-ho...