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About 1,176,790 results

Effectiveness of a Third Dose of MMR Vaccine for Mumps Outbreak Control.
https://doi.org/10.1056/NEJMoa1703309
The New England Journal of Medicine; Cardemil CV, Dahl RM et. al.

Sep 6th, 2017 - The effect of a third dose of the measles-mumps-rubella (MMR) vaccine in stemming a mumps outbreak is unknown. During an outbreak among vaccinated students at the University of Iowa, health officials implemented a widespread MMR vaccine campaign. We evaluated the effectiveness of a third dose for outbreak control and assessed for waning immunity. Of 20,496 university students who were enrolled ...

Association of Preoperatively Diagnosed Patent Foramen Ovale With Perioperative Ischemi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839297
JAMA Ng PY, Ng AK et. al.

Feb 7th, 2018 - Perioperative stroke is a major complication for patients undergoing surgery. Patent foramen ovale (PFO) represents a possible anatomical link between venous thrombosis and stroke. To determine whether a preoperatively diagnosed PFO is associated with increased risk of perioperative ischemic stroke. Retrospective cohort study from Massachusetts General Hospital and 2 affiliated community hospit...

Birth Outcomes for Pregnant Women with HIV Using Tenofovir-Emtricitabine.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984044
The New England Journal of Medicine; Rough K, Seage GR et. al.

Apr 25th, 2018 - In a previous trial of antiretroviral therapy (ART) involving pregnant women with human immunodeficiency virus (HIV) infection, those randomly assigned to receive tenofovir, emtricitabine, and ritonavir-boosted lopinavir (TDF-FTC-LPV/r) had infants at greater risk for very premature birth and death within 14 days after delivery than those assigned to receive zidovudine, lamivudine, and ritonavi...

Risk of post-pregnancy hypertension in women with a history of hypertensive disorders o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506851
BMJ (Clinical Research Ed.); Behrens I, Basit S et. al.

Jul 13th, 2017 - Objectives To determine how soon after delivery the risk of post-pregnancy hypertension increases in women with hypertensive disorders of pregnancy and how the risk evolves over time.Design Nationwide register based cohort study.Setting Denmark.Populations 482 972 primiparous women with a first live birth or stillbirth between 1995 and 2012 (cumulative incidence analyses), and 1 025 118 women w...

Cystic Fibrosis Colorectal Cancer Screening Consensus Recommendations.
https://doi.org/10.1053/j.gastro.2017.12.012
Gastroenterology Hadjiliadis D, Khoruts A et. al.

Dec 31st, 2017 - Improved therapy has substantially increased survival of persons with cystic fibrosis (CF). But the risk of colorectal cancer (CRC) in adults with CF is 5-10 times greater compared to the general population, and 25-30 times greater in CF patients after an organ transplantation. To address this risk, the CF Foundation convened a multi-stakeholder task force to develop CRC screening recommendatio...

Late Relapse of Classical Hodgkin Lymphoma: An Analysis of the German Hodgkin Study Gro...
https://doi.org/10.1200/JCO.2016.71.3289
Journal of Clinical Oncology : Official Journal of the Am... Bröckelmann PJ, Goergen H et. al.

Feb 27th, 2017 - Purpose Clinical characteristics, therapeutic approaches, and prognosis of late relapse (LR) in patients with classic Hodgkin lymphoma (cHL) are poorly understood. We performed a comprehensive analysis of LR of Hodgkin lymphoma (LR-HL). Methods To estimate the incidence of LR-HL, we retrospectively analyzed 6,840 patients with cHL included in the German Hodgkin Study Group trials HD7 to HD12. P...

Association Between Proton Pump Inhibitor Use and Risk of Progression of Chronic Kidney...
https://doi.org/10.1053/j.gastro.2017.05.046
Gastroenterology Klatte DCF, Gasparini A et. al.

Jun 6th, 2017 - Proton pump inhibitors (PPI) have been associated with acute kidney injury and recent studies suggest that they may be associated with the risk of chronic kidney disease (CKD). We performed a retrospective analysis using the Stockholm creatinine measurements database, which contains information on diagnoses, dispensation claims, and laboratory test results for all citizens in the Stockholm regi...

History of breast feeding and risk of incident endometriosis: prospective cohort study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574033
BMJ (Clinical Research Ed.); Farland LV, Eliassen AH et. al.

Aug 30th, 2017 - Objective To investigate the association between lifetime breast feeding, exclusive breast feeding, postpartum amenorrhea, and incidence of endometriosis among parous women.Design Prospective cohort study.Setting Nurses' Health Study II, 1989-2011.Participants 72 394women who reported having one or more pregnancies that lasted at least six months, 3296 of whom had laparoscopically confirmed end...

Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervent...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876881
JAMA Berwanger O, Santucci EV et. al.

Mar 11th, 2018 - The effects of loading doses of statins on clinical outcomes in patients with acute coronary syndrome (ACS) and planned invasive management remain uncertain. To determine if periprocedural loading doses of atorvastatin decrease 30-day major adverse cardiovascular events (MACE) in patients with ACS and planned invasive management. Multicenter, double-blind, placebo-controlled, randomized clinica...

Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842359
BMJ (Clinical Research Ed.); Pasternak B, Inghammar M et. al.

Mar 9th, 2018 - To investigate whether oral fluoroquinolone use is associated with an increased risk of aortic aneurysm or dissection. Nationwide historical cohort study using linked register data on patient characteristics, filled prescriptions, and cases of aortic aneurysm or dissection. Sweden, July 2006 to December 2013. 360 088 treatment episodes of fluoroquinolone use (78%ciprofloxacin) and propensity sc...

Low-Fat Dietary Pattern and Breast Cancer Mortality in the Women's Health Initiative Ra...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578391
Journal of Clinical Oncology : Official Journal of the Am... Chlebowski RT, Aragaki AK et. al.

Jun 27th, 2017 - Purpose Earlier Women's Health Initiative Dietary Modification trial findings suggested that a low-fat eating pattern may reduce breast cancers with greater mortality. Therefore, as a primary outcome-related analysis from a randomized prevention trial, we examined the long-term influence of this intervention on deaths as a result of and after breast cancer during 8.5 years (median) of dietary i...

Three Rotavirus Outbreaks in the Postvaccine Era - California, 2017.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919604
MMWR. Morbidity and Mortality Weekly Report; Burke RM, Tate JE et. al.

Apr 26th, 2018 - Before the introduction of rotavirus vaccine in 2006, rotavirus was the most common cause of severe diarrhea among U.S. children (1). Currently, two rotavirus vaccines are licensed for use in the United States, both of which have demonstrated good field effectiveness (78%-89%) against moderate to severe rotavirus illness (2), and the use of these vaccines has substantially reduced the prevalenc...

Risk of suicide following an alcohol-related emergency hospital admission: An electroni...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922531
PloS One; Bowden B, John A et. al.

Apr 27th, 2018 - Alcohol misuse is a well-known risk factor for suicide however, the relationship between alcohol-related hospital admission and subsequent risk of death from suicide is unknown. We aimed to determine the risk of death from suicide following emergency admission to hospital with an alcohol-related cause. We established an electronic cohort study of all 2,803,457 residents of Wales, UK, aged from ...

High-Quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Q...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526717
Gastroenterology Park SY, Boushey CJ et. al.

Apr 21st, 2017 - Healthy eating patterns assessed by diet quality indexes (DQIs) have been related to lower risk of colorectal cancer-mostly among whites. We investigated the associations between 4 DQI scores (the Healthy Eating Index 2010 [HEI-2010], the Alternative Healthy Eating Index 2010 [AHEI-2010], the alternate Mediterranean diet score [aMED], and the Dietary Approaches to Stop Hypertension score) and c...

Public health impact of colonoscopy use on colorectal cancer mortality in Germany and t...
https://doi.org/10.1016/j.gie.2017.04.005
Gastrointestinal Endoscopy; Chen C, Stock C et. al.

Apr 22nd, 2017 - Colonoscopy has been demonstrated to be effective in reducing colorectal cancer (CRC) incidence and mortality and has been widely used for primary CRC screening in Germany and the United States. We performed a population-based analysis to evaluate and compare the public health impact of recent colonoscopy use on CRC deaths among adults aged 55 to 79 years in Germany and the United States from 2...

Outcomes With Transcatheter Mitral Valve Repair in the United States: An STS/ACC TVT Re...
https://doi.org/10.1016/j.jacc.2017.09.015
Journal of the American College of Cardiology; Sorajja P, Vemulapalli S et. al.

Nov 3rd, 2017 - Post-market surveillance is needed to evaluate the real-world clinical effectiveness and safety of U.S. Food and Drug Administration-approved devices. The authors examined the commercial experience with transcatheter mitral valve repair for the treatment of mitral regurgitation. Data from the Society of Thoracic Surgery/American College of Cardiology Transcatheter Valve Therapy Registry on pati...

Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation.
https://doi.org/10.1056/NEJMoa1708454
The New England Journal of Medicine; Cannon CP, Bhatt DL et. al.

Aug 28th, 2017 - Triple antithrombotic therapy with warfarin plus two antiplatelet agents is the standard of care after percutaneous coronary intervention (PCI) for patients with atrial fibrillation, but this therapy is associated with a high risk of bleeding. In this multicenter trial, we randomly assigned 2725 patients with atrial fibrillation who had undergone PCI to triple therapy with warfarin plus a P2Y12...

Vital Signs: Trends in Emergency Department Visits for Suspected Opioid Overdoses - Uni...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844282
MMWR. Morbidity and Mortality Weekly Report; Vivolo-Kantor AM, Seth P et. al.

Mar 8th, 2018 - From 2015 to 2016, opioid overdose deaths increased 27.7%, indicating a worsening of the opioid overdose epidemic and highlighting the importance of rapid data collection, analysis, and dissemination. Emergency department (ED) syndromic and hospital billing data on opioid-involved overdoses during July 2016-September 2017 were examined. Temporal trends in opioid overdoses from 52 jurisdictions ...

Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.
https://doi.org/10.1056/NEJMoa1612917
The New England Journal of Medicine; Holman RR, Bethel MA et. al.

Sep 14th, 2017 - The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first oc...

Comorbidity in multiple sclerosis is associated with diagnostic delays and increased mo...
https://doi.org/10.1212/WNL.0000000000004508
Neurology Thormann A, Sørensen PS et. al.

Sep 21st, 2017 - To investigate the effect of chronic comorbidity on the time of diagnosis of multiple sclerosis (MS) and on mortality in MS. We conducted a population-based, nationwide cohort study including all incident MS cases in Denmark with first MS symptom between 1980 and 2005. To investigate the time of diagnosis, we compared individuals with and without chronic comorbidity using multinomial logistic r...