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About 152,130 results

An investigation of cultural influences in survivors of paediatric cancer: a systematic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685191
BMJ Open; Hou SHJ, Schulte FSM

Nov 23rd, 2022 - Paediatric cancer affects children and families from diverse backgrounds. However, there is a limited understanding of how diversity/cultural factors play a role, especially in survivorship. This protocol outlines a systematic review on the cultural influences in survivors of childhood cancer. This protocol is reported based on the Preferred Reporting Items for Systematic Review and Meta-Analys...

Lactase persistence phenotype and genotype in Iranian Mazani-Shahmirzadi and Afghan Haz...
https://doi.org/10.1016/j.ejmg.2022.104656
European Journal of Medical Genetics; Rajabloo S, Marefat E et. al.

Nov 6th, 2022 - Lactase persistence is an autosomal dominant trait characterized by sustained expression of lactase gene throughout adulthood. This trait is mostly prevalent in populations with pastoral or agro-pastoral ancestry and allows lactase persistent individuals to benefit from milk nutrients. Several genetic variants have been identified to be responsible for lactase persistence in different populatio...

Hereditary variants of unknown significance in African American women with breast cancer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621418
PloS One; McDonald JT, Ricks-Santi LJ

Nov 1st, 2022 - Expanded implementation of genetic sequencing has precipitously increased the discovery of germline and somatic variants. The direct benefit of identifying variants in actionable genes may lead to risk reduction strategies such as increased surveillance, prophylactic surgery, as well as lifestyle modifications to reduce morbidity and mortality. However, patients with African ancestry are more l...

Racial and Ethnic Differences in Bystander CPR for Witnessed Cardiac Arrest.
https://doi.org/10.1056/NEJMoa2200798
The New England Journal of Medicine; Garcia RA, Spertus JA et. al.

Oct 28th, 2022 - Differences in the incidence of cardiopulmonary resuscitation (CPR) provided by bystanders contribute to survival disparities among persons with out-of-hospital cardiac arrest. It is critical to understand whether the incidence of bystander CPR in witnessed out-of-hospital cardiac arrests at home and in public settings differs according to the race or ethnic group of the person with cardiac arr...

A Jamaican medicinal-plant scientist explores his African roots.
https://doi.org/10.1038/d41586-022-03254-x
Nature Reid C

Oct 20th, 2022 - A Jamaican medicinal-plant scientist explores his African roots.|2022|Reid C,|ethnology,

Evolution of immune genes is associated with the Black Death.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580435
Nature Klunk J, Vilgalys TP et. al.

Oct 20th, 2022 - Infectious diseases are among the strongest selective pressures driving human evolution1,2. This includes the single greatest mortality event in recorded history, the first outbreak of the second pandemic of plague, commonly called the Black Death, which was caused by the bacterium Yersinia pestis3. This pandemic devastated Afro-Eurasia, killing up to 30-50% of the populat...

School Disengagement Predicts Accelerated Aging among Black American Youth: Mediation b...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564392
International Journal of Environmental Research and Publi... Ong ML, Klopack ET et. al.

Oct 15th, 2022 - Early experiences of school disengagement may serve as a warning sign for later young adult adjustment difficulties and eventually contribute to accelerated aging among Black American youth. At the same time, supportive parenting may play a protective role. Using longitudinal data from the Family and Community Health Study (FACHS), we examined psychological maladjustment (comprising depression,...

The Role of Social Support in Cardiovascular Clinical Trial Participation among Black M...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566142
International Journal of Environmental Research and Publi... Addison S, Yang Y et. al.

Oct 15th, 2022 - Attainment of the American Heart Association's Life's Simple 7 (LS7) metrics reduces cardiovascular disease (CVD) risk; yet, Black Americans have the lowest LS7 attainment among all communities, the highest rate of CVD mortality, and low clinical trial participation. Social support is positively correlated with chronic disease self-management. Here, we describe the role of social support in a s...

In-silico study of influence of HLA heterogeneity on CTL responses across ethnicities t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550298
Human Immunology; Rao V, Chandra N

Oct 14th, 2022 - Differences in outcome to COVID-19 infection in different individuals is largely attributed to genetic heterogeneity leading to differential immune responses across individuals and populations. HLA is one such genetic factor that varies across individuals leading to differences in how T-cell responses are triggered against SARS-CoV-2, directly influencing disease susceptibility. HLA alleles tha...

Burden of lymphedema in long-term breast cancer survivors by race and age.
https://doi.org/10.1002/cncr.34489
Cancer Ren Y, Kebede MA et. al.

Oct 13th, 2022 - Risk assessment for breast cancer-related lymphedema has emphasized upper-limb symptoms and treatment-related risk factors. This article examined breast cancer-related lymphedema after surgery, overall and in association with broader demographic and clinical features. The Carolina Breast Cancer Study phase 3 followed participants for breast cancer-related lymphedema from baseline (on average, 5...

A saturated map of common genetic variants associated with human height.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605867
Nature Yengo L, Vedantam S et. al.

Oct 13th, 2022 - Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated ...

The Impact of Race, Insurance, and Socioeconomic Factors on Pediatric Knee Injuries.
https://doi.org/10.1016/j.csm.2022.05.012
Clinics in Sports Medicine; Patel NM, Edison BR et. al.

Oct 10th, 2022 - Disparities persist in pediatric sports medicine along the lines of race, ethnicity, insurance status, and other demographic factors. In the context of knee injuries such as anterior cruciate ligament (ACL) ruptures, meniscus tears, and tibial spine fractures, these inequalities affect evaluation, treatment, and outcomes. The long-term effects can be far-reaching, including sports and physical ...

Stroke genetics informs drug discovery and risk prediction across ancestries.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524349
Nature Mishra A, Malik R et. al.

Oct 1st, 2022 - Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89...

Dynamics of racial disparities in all-cause mortality during the COVID-19 pandemic.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546535
Proceedings of the National Academy of Sciences of the Un... Aschmann HE, Riley AR et. al.

Sep 21st, 2022 - As research documenting disparate impacts of COVID-19 by race and ethnicity grows, little attention has been given to dynamics in mortality disparities during the pandemic and whether changes in disparities persist. We estimate age-standardized monthly all-cause mortality in the United States from January 2018 through February 2022 for seven racial/ethnic populations. Using joinpoint regression...

A review of African American women's experiences in menopause.
https://doi.org/10.1097/GME.0000000000002060
Menopause (New York, N.Y.); Williams M, Richard-Davis G et. al.

Sep 21st, 2022 - Little is known and reported about the experiences of African American women as they transition to and experience menopause. Accepted norms are based on the experience of a predominantly White population. The aim of this study is to review available data about the distinct experiences of African American women during the menopause transition and menopause. A literature search was developed and ...

Adult Day Services, Health Equity for Older Adults With Complex Needs, and the COVID-19...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480461
American Journal of Public Health; Sadarangani TR, Gaugler JE et. al.

Sep 15th, 2022 - Morbidity and mortality from COVID-19 have unduly affected older adults from racial and ethnic minority groups. In this article, we highlight the experiences and vulnerabilities of diverse older adults with complex health and social needs when their access to vital, but overlooked, community-based adult day service centers (ADSCs) was abruptly cut off during a pandemic. Pandemic-related ADSC cl...

Race, Interleukin-6, TMPRSS6 Genotype, and Cardiovascular Disease in Patients With Chro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683639
Journal of the American Heart Association; Barrows IR, Devalaraja M et. al.

Sep 15th, 2022 - Background Differences in death rate and cardiovascular disease (CVD) between Black and White patients with chronic kidney disease is attributed to sociocultural factors, comorbidities, genetics, and inflammation. Methods and Results We examined the interaction of race, plasma IL-6 (interleukin-6), and TMPRSS6 genotype as determinants of CVD and mortality in 3031 Chronic Renal Insufficiency Coh...

Association of Race and Ethnicity With Prescription of SGLT2 Inhibitors and GLP1 Recept...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449794
JAMA Lamprea-Montealegre JA, Madden E et. al.

Sep 7th, 2022 - Novel therapies for type 2 diabetes can reduce the risk of cardiovascular disease and chronic kidney disease progression. The equitability of these agents' prescription across racial and ethnic groups has not been well-evaluated. To investigate differences in the prescription of sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RA) among adu...

African-specific molecular taxonomy of prostate cancer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477733
Nature Jaratlerdsiri W, Jiang J et. al.

Sep 1st, 2022 - Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry is a significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than global averages1. The contributing genetic and non-genetic factors, and associated mutational processes, are unknown2,3. Here, through whole-genome sequencing of treatment-naive prostate cancer samples from 1...

Efficacy and Safety of Brigatinib Compared With Crizotinib in Asian vs. Non-Asian Patie...
https://doi.org/10.1016/j.cllc.2022.07.008
Clinical Lung Cancer; Ahn MJ, Kim HR et. al.

Aug 30th, 2022 - Brigatinib is a next-generation anaplastic lymphoma kinase (ALK) inhibitor with demonstrated efficacy in locally advanced and metastatic non-small cell lung cancer (NSCLC) in crizotinib-refractory and ALK inhibitor-naive settings. This analysis assessed brigatinib in Asian vs. non-Asian patients from the first-line ALTA-1L trial. This was a subgroup analysis from the phase III ALTA-1L trial of ...