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About 1,101,346 results

Association of Preoperatively Diagnosed Patent Foramen Ovale With Perioperative Ischemi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839297
JAMA Ng PY, Ng AK et. al.

Feb 7th, 2018 - Perioperative stroke is a major complication for patients undergoing surgery. Patent foramen ovale (PFO) represents a possible anatomical link between venous thrombosis and stroke. To determine whether a preoperatively diagnosed PFO is associated with increased risk of perioperative ischemic stroke. Retrospective cohort study from Massachusetts General Hospital and 2 affiliated community hospit...

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus.
https://doi.org/10.1056/NEJMoa1803760
The New England Journal of Medicine; Fenske W, Refardt J et. al.

Aug 1st, 2018 - The indirect water-deprivation test is the current reference standard for the diagnosis of diabetes insipidus. However, it is technically cumbersome to administer, and the results are often inaccurate. The current study compared the indirect water-deprivation test with direct detection of plasma copeptin, a precursor-derived surrogate of arginine vasopressin. From 2013 to 2017, we recruited 156...

Efficacy of Laparoscopic Nissen Fundoplication vs Transoral Incisionless Fundoplication...
https://doi.org/10.1053/j.gastro.2017.12.021
Gastroenterology Richter JE, Kumar A et. al.

Jan 6th, 2018 - The effects of transoral incisionless fundoplication (TIF) and laparoscopic Nissen fundoplication (LNF) have been compared with those of proton pump inhibitors (PPIs) or a sham procedure in patients with gastroesophageal reflux disease (GERD), but there has been no direct comparison of TIF vs LNF. We performed a systematic review and network meta-analysis of randomized controlled trials to comp...

Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy.
https://doi.org/10.1056/NEJMoa1612645
The New England Journal of Medicine; Masuda N, Lee SJ et. al.

May 31st, 2017 - Patients who have residual invasive carcinoma after the receipt of neoadjuvant chemotherapy for human epidermal growth factor receptor 2 (HER2)-negative breast cancer have poor prognoses. The benefit of adjuvant chemotherapy in these patients remains unclear. We randomly assigned 910 patients with HER2-negative residual invasive breast cancer after neoadjuvant chemotherapy (containing anthracyc...

Effect of Oral Prednisolone on Symptom Duration and Severity in Nonasthmatic Adults Wit...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817483
JAMA Hay AD, Little P et. al.

Aug 22nd, 2017 - Acute lower respiratory tract infection is common and often treated inappropriately in primary care with antibiotics. Corticosteroids are increasingly used but without sufficient evidence. To assess the effects of oral corticosteroids for acute lower respiratory tract infection in adults without asthma. Multicenter, placebo-controlled, randomized trial (July 2013 to final follow-up October 2014...

Effect of Bag-Mask Ventilation vs Endotracheal Intubation During Cardiopulmonary Resusc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838565
JAMA Jabre P, Penaloza A et. al.

Feb 27th, 2018 - Bag-mask ventilation (BMV) is a less complex technique than endotracheal intubation (ETI) for airway management during the advanced cardiac life support phase of cardiopulmonary resuscitation of patients with out-of-hospital cardiorespiratory arrest. It has been reported as superior in terms of survival. To assess noninferiority of BMV vs ETI for advanced airway management with regard to surviv...

Opioid Knowledge and Prescribing Practices Among Obstetrician-Gynecologists.
https://doi.org/10.1097/AOG.0000000000002407
Obstetrics and Gynecology; Madsen AM, Stark LM et. al.

Dec 7th, 2017 - To describe obstetrician-gynecologists' (ob-gyns) knowledge and prescribing practices regarding opioid analgesics. We conducted a cross-sectional survey of a national sample of American College of Obstetricians and Gynecologists Fellows and Junior Fellows who are part of the Collaborative Ambulatory Research Network. We used a sequential mixed-method approach. We collected data on opioid knowle...

High-Quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Q...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526717
Gastroenterology Park SY, Boushey CJ et. al.

Apr 21st, 2017 - Healthy eating patterns assessed by diet quality indexes (DQIs) have been related to lower risk of colorectal cancer-mostly among whites. We investigated the associations between 4 DQI scores (the Healthy Eating Index 2010 [HEI-2010], the Alternative Healthy Eating Index 2010 [AHEI-2010], the alternate Mediterranean diet score [aMED], and the Dietary Approaches to Stop Hypertension score) and c...

Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy: A Sy...
https://doi.org/10.7326/M17-0598
Annals of Internal Medicine; Frank JW, Lovejoy TI et. al.

Jul 17th, 2017 - Expert guidelines recommend reducing or discontinuing long-term opioid therapy (LTOT) when risks outweigh benefits, but evidence on the effect of dose reduction on patient outcomes has not been systematically reviewed. To synthesize studies of the effectiveness of strategies to reduce or discontinue LTOT and patient outcomes after dose reduction among adults prescribed LTOT for chronic pain. ME...

Venetoclax-Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia.
https://doi.org/10.1056/NEJMoa1713976
The New England Journal of Medicine; Seymour JF, Kipps TJ et. al.

Mar 21st, 2018 - Venetoclax inhibits BCL2, an antiapoptotic protein that is pathologically overexpressed and that is central to the survival of chronic lymphocytic leukemia cells. We evaluated the efficacy of venetoclax in combination with rituximab in patients with relapsed or refractory chronic lymphocytic leukemia. In this randomized, open-label, phase 3 trial, we randomly assigned 389 patients to receive ve...

Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome...
https://doi.org/10.1001/jama.2019.4149
JAMA Nordberg P, Taccone FS et. al.

May 7th, 2019 - Therapeutic hypothermia may increase survival with good neurologic outcome after cardiac arrest. Trans-nasal evaporative cooling is a method used to induce cooling, primarily of the brain, during cardiopulmonary resuscitation (ie, intra-arrest). To determine whether prehospital trans-nasal evaporative intra-arrest cooling improves survival with good neurologic outcome compared with cooling init...

Effect of Mechanically Expanded vs Self-Expanding Transcatheter Aortic Valve Replacemen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833545
JAMA Feldman TE, Reardon MJ et. al.

Jan 3rd, 2018 - Transcatheter aortic valve replacement (TAVR) is established for selected patients with severe aortic stenosis. However, limitations such as suboptimal deployment, conduction disturbances, and paravalvular leak occur. To evaluate if a mechanically expanded valve (MEV) is noninferior to an approved self-expanding valve (SEV) in high-risk patients with aortic stenosis undergoing TAVR. The REPRISE...

Pregnancy outcome following in utero exposure to lithium: a prospective, comparative, o...
https://doi.org/10.1176/appi.ajp.2014.12111402
The American Journal of Psychiatry; Diav-Citrin O, Shechtman S et. al.

May 1st, 2014 - The authors conducted a prospective, comparative observational study to evaluate the risk of major anomalies following exposure to lithium during pregnancy. A total of 183 lithium-exposed pregnancies of women who contacted the Israeli Teratology Information Service were followed up (90.2% in the first trimester) and compared with 72 disease-matched and 748 nonteratogenic-exposed pregnancies. Th...

FXR is a molecular target for the effects of vertical sleeve gastrectomy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016120
Nature Ryan KK, Tremaroli V et. al.

Mar 28th, 2014 - Bariatric surgical procedures, such as vertical sleeve gastrectomy (VSG), are at present the most effective therapy for the treatment of obesity, and are associated with considerable improvements in co-morbidities, including type-2 diabetes mellitus. The underlying molecular mechanisms contributing to these benefits remain largely undetermined, despite offering the potential to reveal new targe...

Drug reaction with eosinophilia and systemic symptoms, or virus reactivation with eosin...
https://doi.org/10.1111/bjd.13079
The British Journal of Dermatology; Almudimeegh A, Rioux C et. al.

Apr 29th, 2014 - We report a case of drug reaction with eosinophilia and systemic symptoms (DRESS) in a patient with HIV receiving antitoxoplasmic drugs (adiazine and pyrimethamine) and levetiracetam along with highly active antiretroviral therapy (tenofovir-emtricitabine, darunavir and ritonavir). Cytomegalovirus (CMV) infection was reactivated in the 7 weeks before the development of DRESS but was successfull...

Management of gastrointestinal angiodysplastic lesions (GIADs): a systematic review and...
https://doi.org/10.1038/ajg.2014.19
The American Journal of Gastroenterology; Jackson CS, Gerson LB

Mar 19th, 2014 - Gastrointestinal angiodysplastic lesions (GIADs) are defined as pathologically dilated communications between veins and capillaries. The objective of this systematic review and meta-analysis was to determine the efficacy of available treatment modalities for GIADs. We identified eligible studies by searching through PubMed, SCOPUS, and Cochrane central register of controlled trials. We searched...

Effect of acetazolamide on visual function in patients with idiopathic intracranial hyp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362615
JAMA , Wall M et. al.

Apr 23rd, 2014 - Acetazolamide is commonly used to treat idiopathic intracranial hypertension (IIH), but there is insufficient information to establish an evidence base for its use. To determine whether acetazolamide is beneficial in improving vision when added to a low-sodium weight reduction diet in patients with IIH and mild visual loss. Multicenter, randomized, double-masked, placebo-controlled study of ace...

Withholding or termination of resuscitation in pediatric out-of-hospital traumatic card...
https://doi.org/10.1542/peds.2014-0176
Pediatrics , et. al.

Apr 1st, 2014 - This multiorganizational literature review was undertaken to provide an evidence base for determining whether recommendations for out-of-hospital termination of resuscitation could be made for children who are victims of traumatic cardiopulmonary arrest. Although there is increasing acceptance of out-of-hospital termination of resuscitation for adult traumatic cardiopulmonary arrest when there ...

Door-to-needle times for tissue plasminogen activator administration and clinical outco...
https://doi.org/10.1001/jama.2014.3203
JAMA Fonarow GC, Zhao X et. al.

Apr 23rd, 2014 - The benefits of intravenous tissue plasminogen activator (tPA) in patients with acute ischemic stroke (AIS) are time dependent and guidelines recommend a door-to-needle (DTN) time of 60 minutes or less. However, studies have found that less than 30% of US patients are treated within this time window. Stroke was designed as a national quality improvement initiative to improve DTN times for tPA a...

Cervical spine injury patterns in children.
https://doi.org/10.1542/peds.2013-3505
Pediatrics Leonard JR, Jaffe DM et. al.

Apr 29th, 2014 - Pediatric cervical spine injuries (CSIs) are rare and differ from adult CSIs. Our objective was to describe CSIs in a large, representative cohort of children. We conducted a 5-year retrospective review of children <16 years old with CSIs at 17 Pediatric Emergency Care Applied Research Network hospitals. Investigators reviewed imaging reports and consultations to assign CSI type. We described c...