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About 2,204,258 results

Biomarker-Driven Analysis Using High-Throughput Approaches in Neuroinflammation and Neu...
https://doi.org/10.1007/978-3-030-78787-5_8 10.1007/s10973-019-08610-0 10.3390/ijms20236008 10.1038/s41593-018-0221-2 10.1136/bjophthalmol-2015-308329 10.2741/e811 10.3233/JAD-190863 10.3390/ijms18020248 10.1155/2015/964518 10.3233/JAD-160763 10.1016/j.mehy.2013.09.008 10.1016/j.freeradbiomed.2012.09.027 10.1016/S0197-4580(01)00257-3 10.1097/00002093-200207000-00005 10.1007/s11064-009-9960-5 10.1586/14737175.8.11.1703 10.1038/s41582-020-0344-4 10.3389/fmolb.2015.00054 10.1097/COH.0b013e32833ed177 10.3389/fneur.2015.00256 10.1586/14737159.2016.1133298 10.2353/jmoldx.2006.060012 10.1093/hmg/ddu203 10.1038/nrg.2017.117 10.15252/msb.20156351 10.1017/S0033583516000160 10.1002/cpps.62
Advances in Experimental Medicine and Biology; Krokidis MG

Jan 14th, 2022 - Aging is responsible for homeostatic dysregulation and the primary risk for neurodegenerative diseases. The main signaling pathways may regulate inflammatory-related disorders and neurodegeneration include genomic instability, cell senescence, and mitochondria dysfunction. The use of high-throughput technologies has emerged as a powerful approach to the rapid discovery of many candidate biomark...

Genotypic and Clinical Analysis of a Thalassemia Major Cohort: An Observational Study.
https://doi.org/10.1007/978-3-030-78787-5_10 10.1038/ejhg.2010.90 10.5045/br.2019.54.1.17 10.1182/blood-2005-03-0948 10.2147/tacg.s178546 10.1007/s00277-006-0136-y 10.1007/s002239900637 10.1007/s42000-018-0019-3 10.2174/1566524019666190314114447 10.1074/jbc.M114.628313 10.1056/NEJMoa1305224 10.1371/journal.pone.0062295 10.1056/NEJMoa1607948 10.5812/ijem.12104 10.1080/17474086.2019.1662721 10.1016/j.transci.2019.03.021 10.1161/circulationaha.106.648790 10.4103/2230-8210.126525 10.1002/14651858.CD010429.pub2 10.1016/j.bone.2005.10.001 10.1016/j.bone.2017.10.016 10.3109/08880019409141689
Advances in Experimental Medicine and Biology; A T, Lambrou GI et. al.

Jan 14th, 2022 - Thalassemia major (TM) is a hereditary disease caused by defective globin synthesis. Because of the significant increase in life expectancy, these patients are suffering from various health conditions, including endocrinopathies and low bone mineral density. The aim of the present study was to investigate the correlation between clinical and biochemical parameters as well as to identify possibl...

The Development of Antisense RNA Treatments Using Engineered Protein Substrates.
https://doi.org/10.1007/978-3-030-78787-5_7 10.1038/s41557-018-0196-3 10.1103/PhysRevA.45.6479 10.1016/B978-0-12-396962-0.00012-4 10.1038/nrneurol.2017.148 10.1016/j.antiviral.2007.12.008
Advances in Experimental Medicine and Biology; Harney M

Jan 14th, 2022 - Current efforts to design supercharged protein assemblies have opened the door for the creation of substrates that could be used for drug delivery and as substrates for antiviral delivery mechanisms. We explore the potential for antiviral delivery with antisense RNAs that bind their phosphate backbone to the charge of an engineered protein oligomer, providing structural integrity to the RNA str...

Kisspeptin and the Genetic Obesity Interactome.
https://doi.org/10.1007/978-3-030-78787-5_15 10.1007/978-3-319-57379-3_21 10.1111/obr.12531 10.1159/000115336 10.6065/apem.2013.18.2.55 10.1016/j.yfrne.2017.07.008 10.1038/s41574-020-0363-7 10.1038/nrendo.2011.147 10.1210/jc.2016-2573 10.1093/hmg/ddv097 10.1038/ng.2776 10.1038/509 10.1007/s00438-015-1015-9 10.6065/apem.2016.21.3.126 10.1093/nar/gku1003 10.1172/JCI68035 10.1172/JCI68016 10.1016/j.ymgme.2016.01.003 10.1159/000455968
Advances in Experimental Medicine and Biology; S G, Pavlopoulou A et. al.

Jan 14th, 2022 - Kisspeptin (encoded by the KISS1 gene in humans) is an excitatory neuromodulatory peptide implicated in multiple homeostatic systems, including anti-oxidation, glucose homeostasis, nutrition, locomotion, etc. Therefore, in the current obesity epidemic, kisspeptin is gaining increasing interest as a research objective. To construct an updated interactome of genetic obesity, including the kisspep...

The Importance of Diagnostic and Prognostic Biomarker Identification and Classification...
https://doi.org/10.1007/978-3-030-78787-5_16
Advances in Experimental Medicine and Biology; Kadena K, Vlamos P

Jan 14th, 2022 - ALS is increasingly perceived as a multisystem neurodegenerative disorder, and the identification of a panel of biomarkers that accurately reflect features of pathology is a priority, not only for diagnostic purposes but also for prognostic or predictive applications [1]. Thus, as a multisystemic disease, it is likely that a panel of biomarkers will be needed to fully capture the features of AL...

Early and Very Early GRIM19 and MCL1 Expression Are Correlated to Late Acquired Prednis...
https://doi.org/10.1007/978-3-030-78787-5_20 10.1016/j.leukres.2009.04.018 10.1055/s-2001-16848 10.1001/jamaoncol.2019.5582 10.31557/apjcp.2019.20.9.2619 10.1002/ajh.25619 10.1007/s12185-019-02703-0 10.1007/s12185-019-02678-y 10.1182/blood.V70.3.860.860 10.1182/blood-2006-11-056366 10.1158/1078-0432.CCR-04-2097 10.1186/s10020-019-0106-1 10.2174/2589977512666200220122650 10.22034/apjcp.2018.19.8.2319 10.1038/cddis.2017.344 10.1016/S1567-5769(02)00081-4 10.2174/1389450003349056 10.1016/j.mce.2012.01.003 10.1177/1010428317694308 10.1371/journal.pone.0072326 10.1016/j.leukres.2015.04.012 10.1002/1097-0142(196611)19:11<1725::aid-cncr2820191142>3.0.co;2-t 10.1002/humu.20533 10.1097/00008571-200011000-00006 10.1093/nar/gki475 10.1093/nar/gkt439 10.1093/nar/gkx356 10.1002/cyto.990080101 10.1002/cyto.990080617 10.1007/s00432-004-0659-3 10.1074/jbc.M411767200 10.3324/haematol.10543 10.1038/s41419-018-0625-7 10.1038/s41375-018-0201-2 10.3390/cancers11111779 10.1016/j.bbrc.2020.02.165 10.3324/haematol.2013.093823 10.1016/j.ejca.2014.03.011 10.1016/S0960-0760(00)00161-8
Advances in Experimental Medicine and Biology; G L, Adamaki M et. al.

Jan 14th, 2022 - Glucocorticoids (GCs) are still first-line drugs for the treatment of childhood acute lymphoblastic leukemia (ALL). Prednisolone is a corticosteroid and one of the most important agents in the treatment of ALL. We report here a study of Prednisolone treatment using as a model a leukemia cell line with subsequent investigation of resistance-related gene expression. Gene silencing has been used i...

Genetic Pathways Involved in the Pathogenesis of Parkinson's Disease.
https://doi.org/10.1007/978-3-030-78787-5_25
Advances in Experimental Medicine and Biology; Skolariki K, Diamantopoulos M et. al.

Jan 14th, 2022 - Parkinson's disease (PD) is the second most common neurodegenerative disease. PD pathogenesis includes both genetic and environmental factors. Previous studies have linked the disease with several genes such as Parkin, SNCA, PINK1 and HTRA2. BiNGO software utilizes GO annotations in order to detect over-represented genes in terms of biological processes, cellular components and molecular functi...

Phenotype and Genotype Study in a Case of Frontometaphyseal Dysplasia 1.
https://doi.org/10.1007/978-3-030-78787-5_38 10.1371/journal.pone.0007830 10.1002/ajmg.a.37044 10.1074/jbc.M207681200 10.1097/00004728-199703000-00009 10.1038/ncb1104-1034 10.1074/jbc.273.3.1689 10.1001/archpedi.1969.02100040489014 10.1002/ajmg.1320050111 10.1002/ajmg.a.10831 10.1002/(SICI)1096-8628(19970822)71:3<341::AID-AJMG16>3.0.CO;2-K 10.1038/ng1119 10.1038/35052082 10.1002/(SICI)1096-8628(20000228)90:5<407::AID-AJMG11>3.0.CO;2-D 10.1016/j.ajhg.2016.05.024
Advances in Experimental Medicine and Biology; Yapijakis C, Vylliotis A et. al.

Jan 14th, 2022 - Frontometaphyseal dysplasia 1 (FMD1) is a rare X-linked craniofacial syndrome belonging in the otopalatodigital spectrum of disorders. Here we present a case with severe FMD1 that was caused by a mutation in the FLNA gene located on Xq28. A diagnosis for FMD1 was clinically set for a 22-year-old male who presented with cranial hyperostosis with marked supraorbital ridge, hypertelorism, progress...

Craniofacial and Neurological Phenotype in a Case of Oculodentodigital Syndrome.
https://doi.org/10.1007/978-3-030-78787-5_39 10.4103/0301-4738.180191 10.1080/13816810.2019.1571616 10.3174/ajnr.A6051 10.3233/JAD-150424 10.1007/s004150200068 10.1002/humu.20958 10.2169/internalmedicine.51.5770 10.1111/odi.12663 10.1007/s10072-020-04569-1 10.1136/jmg.2003.012005
Advances in Experimental Medicine and Biology; Yapijakis C, Kalogera S et. al.

Jan 14th, 2022 - Oculodentodigital syndrome (ODDS) is a rare genetic disorder caused by mutations in the gap junction GJA1 gene encoding connexin-43 (chromosome 6q22). A typical ODDS case is presented. A 40-year-old male patient was examined neurologically and genetically. He had a history of recent parieto-occipital leukodystrophy, some episodes of temporary hearing loss, and characteristic facial features of ...

Clinical and Molecular Study of Common Thrombophilia Mutation Prothrombin G20210A.
https://doi.org/10.1007/978-3-030-78787-5_40 10.1016/j.amepre.2009.12.017 10.1016/j.ajog.2003.11.002 10.1067/mob.2000.106820 10.1016/S0015-0282(99)00360-X 10.1038/nrcardio.2015.83 10.1016/j.thromres.2014.08.014 10.1161/CIRCRESAHA.115.306841 10.1046/j.1365-2362.2003.01185.x 10.1182/blood.V88.10.3698.bloodjournal88103698 10.1055/s-0037-1614563 10.1159/000073576 10.1016/j.pcad.2014.08.005 10.1002/bimj.201300048 10.1161/01.ATV.0000168421.13467.82 10.1182/blood.V120.21.5135.5135 10.1016/S0049-3848(17)30060-9 10.1111/j.1538-7836.2006.02139.x 10.1007/s11239-016-1464-y 10.1161/01.STR.0000170635.45745.b8 10.1007/s00701-009-0505-0 10.1093/labmed/lmv012
Advances in Experimental Medicine and Biology; Angelopoulou A, Vlachakis D et. al.

Jan 14th, 2022 - One of the most common genetic causes associated with thrombophilia is mutation G20210A of the coagulation factor II (F2) gene. Data collected from 355 unrelated Greeks examined for the mutation G20210A over a period of two decades were anonymously analyzed. The statistical analysis confirmed the importance of F2 G20210A in thrombosis and the significance of a positive family history of thrombo...

Skin Mirrors Brain: A Chance for Alzheimer's Disease Research.
https://doi.org/10.1007/978-3-030-78787-5_45
Advances in Experimental Medicine and Biology; Zouboulis CC, Makrantonaki E et. al.

Jan 14th, 2022 - The accessibility of skin and the easy isolation of its cells and matrix components provide a valuable tool for studying the molecular factors involved in human aging. Moreover, increasing evidence corroborates the use of the skin as a model for age-associated pathological conditions in the entire body. Apparently based on the fact that the nervous system and skin share a common ectodermal orig...

Mitochondrial Homeostasis in Neurodegeneration and Ageing.
https://doi.org/10.1007/978-3-030-78787-5_46 10.1038/s41593-018-0332-9 10.1038/s41556-018-0176-2 10.1038/nature14300
Advances in Experimental Medicine and Biology; Tavernarakis N

Jan 14th, 2022 - Ageing is driven by the inexorable and stochastic accumulation of damage in biomolecules vital for proper cellular function. Although this process is fundamentally haphazard and uncontrollable, senescent decline and ageing is broadly influenced by genetic and extrinsic factors. Numerous gene mutations and treatments have been shown to extend the lifespan of diverse organisms ranging from the un...

Biomarkers and Precision Medicine in Alzheimer's Disease.
https://doi.org/10.1007/978-3-030-78787-5_50
Advances in Experimental Medicine and Biology; Sagar R, Pathak P et. al.

Jan 14th, 2022 - Alzheimer's disease (AD) is the most common form of dementia in the elderly, which is the fifth major cause of mortality for people over 65 years. While some of the hereditary genetic risk factors can be connected to the known amyloid and tau hypothesis, many treatments targeting this pathophysiology have failed in clinical trials or ineffectiveness of the drugs are attributed to the heterogene...

The Role of MicroRNAs in Thrombosis.
https://doi.org/10.1007/978-3-030-78787-5_51 10.1016/j.thromres.2018.03.021 10.1016/j.jacc.2016.09.945 10.1158/0008-5472.CAN-15-0390 10.3390/cells9020276 10.1016/j.cell.2007.12.024 10.3389/fpubh.2017.00358 10.1182/blood-2010-02-268011 10.1160/TH16-07-0503 10.1186/1477-9560-3-22 10.1016/j.cca.2020.01.034 10.3390/ijms21103598 10.1097/MD.0000000000009330 10.1111/j.1365-2141.2008.07077.x 10.1016/j.febslet.2014.12.024 10.1101/gad.17221311 10.1007/s11239-010-0460-x 10.1016/j.ijcard.2013.07.028 10.1007/978-1-4020-6650-4 10.1016/j.thromres.2017.10.008 10.3390/ijms21072602 10.1016/B978-0-444-63233-3.00005-1 10.1055/s-0034-1390325 10.1016/j.ebiom.2017.11.022 10.1177/0967772013520101 10.1111/jth.12331 10.1038/bjc.2011.520 10.1161/ATVBAHA.115.306094 10.1007/978-3-319-57379-3_2 10.1007/978-3-030-32633-3_32
Advances in Experimental Medicine and Biology; Yapijakis C

Jan 14th, 2022 - MicroRNAs (miRNAs) are small noncoding regulatory RNA molecules that play a significant role in targeted downregulation of gene expression by RNA silencing and posttranscriptional regulation. Mounting evidence of recent studies indicates that there is dysregulation of expression level of a wide range of miRNAs in a variety of cardiovascular diseases related to thrombosis including venous thromb...

Preimplantation Genetic Testing for Spastic Paraplegia Type 3.
https://doi.org/10.1007/978-3-030-78787-5_42 10.1097/00019052-199708000-00006 10.1001/jamaneurol.2013.1956 10.1007/s10048-019-00565-6 10.1002/mdc3.12184 10.1212/WNL.0b013e3181b04c6c 10.1055/s-0031-1299787 10.1002/pd.325 10.1038/sj.ejhg.5200871 10.1002/(SICI)1097-0223(199603)16:3<262::AID-PD841>3.0.CO;2-F 10.1007/978-3-030-32633-3_28 10.1038/s41467-019-08478-6 10.1186/1471-2377-10-89 10.1038/s41598-019-50911-9 10.1007/s00415-016-8179-z 10.1016/S0022-510X(03)00210-7
Advances in Experimental Medicine and Biology; Yapijakis C, Gintoni I et. al.

Jan 14th, 2022 - Spastic paraplegia type 3 (SPG3) is a common autosomal dominant neurogenetic disease, presenting during childhood with symptoms of mildly progressive spasticity and weakness of the lower limbs. SPG3 develops due to mutations of the ATL1 gene that encodes atlastin-1, a GTPase crucial for the function of dendrites of corticospinal neurons. Here we present a case of preimplantation genetic testing...

Developing Treatments for Alzheimer's and Related Disorders with Precision Medicine: A ...
https://doi.org/10.1007/978-3-030-78787-5_49 10.1016/s0140-6736(17)31363-6 10.1016/j.dadm.2019.02.006 10.1371/journal.pone.0204695 10.1016/j.jalz.2019.05.002 10.3233/jad-180619 10.1016/j.jagp.2013.12.175
Advances in Experimental Medicine and Biology; Avramopoulos D, Kapogiannis D et. al.

Jan 14th, 2022 - Precision medicine, also known as personalized medicine, is concerned with finding the right treatment for the right patient at the right time. It is a way of thinking focused on parsing heterogeneity ultimately down to the level of the individual. Its main mission is to identify characteristics of heterogeneous clinical conditions so as to target tailored therapies to individuals. Precision Me...

Genome-wide investigation of microRNAs and expression profiles during rhizome developme...
https://doi.org/10.1186/s12864-021-08273-y
BMC Genomics; Xing H, Li Y et. al.

Jan 14th, 2022 - MicroRNAs (miRNAs) are endogenous, non-coding small functional RNAs that govern the post-transcriptional regulatory system of gene expression and control the growth and development of plants. Ginger is an herb that is well-known for its flavor and medicinal properties. The genes involved in ginger rhizome development and secondary metabolism have been discovered, but the genome-wide identificat...

Genome-wide high-throughput signal peptide screening via plasmid pUC256E improves prote...
https://doi.org/10.1186/s12864-022-08292-3 10.1016/j.resmic.2010.03.001 10.1016/j.foodres.2014.07.041 10.1371/journal.pone.0187964 10.1128/jb.179.9.3068-3072.1997 10.1007/s00253-010-2849-z 10.1186/s12934-017-0836-0 10.1038/s41587-019-0036-z 10.1021/acs.jafc.8b04183 10.1159/000343921 10.1074/jbc.M112.366351 10.1099/mic.0.26299-0 10.1007/s00253-009-2405-x 10.1128/AEM.67.9.4119 10.1089/cmb.2012.0021 10.1016/J.PLASMID.2006.12.005 10.1186/1754-6834-6-21 10.1006/jmbi.2000.4315 10.1093/nar/gkv468
BMC Genomics; Chen B, Loo BZL et. al.

Jan 14th, 2022 - Proteases catalyze the hydrolysis of peptide bonds of proteins, thereby improving dietary protein digestibility, nutrient availability, as well as flavor and texture of fermented food and feed products. The lactobacilli Lactiplantibacillus plantarum (formerly Lactobacillus plantarum) and Pediococcus acidilactici are widely used in food and feed fermentations due to their broad metabolic capabil...

A systematic review on papers that study on Single Nucleotide Polymorphism that affects...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753023
BMC Infectious Diseases; Suh S, Lee S et. al.

Jan 14th, 2022 - COVID-19, caused by SARS-CoV-2 has become the most threatening issue to all populations around the world. It is, directly and indirectly, affecting all of us and thus, is an emerging topic dealt in global health. To avoid the infection, various studies have been done and are still ongoing. COVID-19 cases are reported all over the globe, and among the millions of cases, genetic similarity may be...

Ocular phenotype and genetical analysis in patients with retinopathy of prematurity.
https://doi.org/10.1186/s12886-022-02252-x 10.1016/S0002-9394(42)92088-9 10.4103/0301-4738.33817 10.1001/archophthalmol.2009.244 10.1542/peds.2004-1309 10.1056/NEJMra1208129 10.1186/1471-2431-5-18 10.3109/14767058.2011.587056 10.1155/2019/2721578 10.1007/s10792-012-9533-5 10.1016/S0092-8674(04)00216-8 10.1172/JCI76431 10.1167/iovs.14-15680 10.1136/bjo.2010.190116 10.3109/13816810903479834 10.1016/j.ophtha.2021.05.031 10.1038/gim.2015.30 10.1074/jbc.M609618200 10.1074/jbc.M110.194399 10.1186/s12862-019-1400-9 10.1016/S1097-2765(03)00427-1 10.1001/archophthalmol.2009.322 10.1167/iovs.17-23541 10.1016/j.exer.2019.107720 10.1002/dvdy.117 10.1038/s41586-018-0447-x
BMC Ophthalmology; Tao T, Meng X et. al.

Jan 14th, 2022 - Retinopathy of prematurity (ROP) is a multifactorial retinal disease, involving both environmental and genetic factors; The purpose of this study is to evaluate the clinical presentations and genetic variants in Chinese patients with ROP. A total of 36 patients diagnosed with ROP were enrolled in this study, their medical and ophthalmic histories were obtained, and comprehensive clinical examin...