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About 2,135,295 results

Association between long non-coding RNA (lncRNA) GAS5 polymorphism rs145204276 and canc...
https://doi.org/10.1177/03000605211039798
The Journal of International Medical Research; Zhao S, Liu P et. al.

Sep 16th, 2021 - The long non-coding RNA (lncRNA) growth arrest‑specific transcript 5 (GAS5) plays an important role in various tumors, and an increasing number of studies have explored the association of the GAS5 rs145204276 polymorphism with cancer risk with inconclusive results. PubMed, Medline, EMBASE, Cochrane databases, and Web of Science were searched, and nine studies involving 6107 cases and 7909 contr...

Choice of pre-processing pipeline influences clustering quality of scRNA-seq datasets.
https://doi.org/10.1186/s12864-021-07930-6 10.1038/s41586-019-1385-y 10.1016/j.cell.2018.05.057 10.1038/s41559-020-1234-2 10.1016/j.cub.2019.05.021 10.1126/science.aaz3090 10.1038/nprot.2017.149 10.1093/bioinformatics/bts635 10.1186/gb-2013-14-4-r36 10.1093/bioinformatics/btq057 10.1038/nbt.3519 10.1038/nbt.2862 10.1038/nmeth.4197 10.1186/s13059-019-1670-y 10.1038/s41587-021-00870-2 10.1016/j.cell.2015.04.044 10.1186/s13059-019-1662-y 10.1016/j.cell.2015.05.002 10.1038/s41467-018-05083-x 10.7554/eLife.55792 10.1371/journal.pone.0121330 10.1038/s41467-019-12266-7 10.1186/s13059-016-0888-1 10.1023/A:1018483627058 10.1371/journal.pbio.2006250 10.1016/j.csbj.2020.06.014 10.1007/s00438-014-0889-2
BMC Genomics; Shainer I, Stemmer M

Sep 16th, 2021 - Single-cell RNA sequencing (scRNA-seq) has quickly become one of the most dominant techniques in modern transcriptome assessment. In particular, 10X Genomics' Chromium system, with its high throughput approach, turn key and thorough user guide made this cutting-edge technique accessible to many laboratories using diverse animal models. However, standard pre-processing, including the alignment a...

Dual RNA-seq transcriptome analysis of caecal tissue during primary Eimeria tenella inf...
https://doi.org/10.1186/s12864-021-07959-7 10.1016/B978-0-12-407705-8.00002-1 10.1016/j.pt.2013.10.003 10.1017/S0031182014000195 10.1186/s13567-020-00837-2 10.3389/fvets.2020.00101 10.1038/nrmicro1800 10.1007/978-0-387-78267-6_2 10.1111/cmi.12255 10.1016/j.ijpara.2012.10.024 10.1186/1471-2148-13-117 10.1016/S0020-7519(01)00255-7 10.1051/parasite/2018061 10.1111/1574-6976.12013 10.1146/annurev-micro-091014-104353 10.1016/j.molbiopara.2004.01.013 10.1107/S1744309113029734 10.1371/journal.pone.0025233 10.3389/fimmu.2019.02732 10.1016/j.vetimm.2008.04.013 10.1016/j.dci.2009.11.006 10.1371/journal.pone.0027712 10.1371/journal.pone.0064236 10.1186/1471-2164-15-806 10.1186/s12864-015-2237-2 10.1371/journal.ppat.1005511 10.1128/mBio.00027-16 10.1186/s12864-017-4095-6 10.1017/S0031182021000111 10.1016/S0169-4758(98)01379-9 10.1080/0307945021000071588 10.1016/0014-4894(70)90063-9 10.1111/pim.12329 10.1017/S0031182018001877 10.1111/pim.12331 10.1016/j.cytogfr.2015.07.003 10.3389/fimmu.2021.653085 10.1186/s12864-018-5090-2 10.1111/j.1365-2249.2005.02840.x 10.1186/1297-9716-45-25 10.1186/s13567-020-00825-6 10.1080/00034983.1993.11812779 10.1097/MOG.0000000000000042 10.1128/IAI.69.4.2527-2534.2001 10.1016/j.vetimm.2006.08.006 10.1016/j.vetpar.2006.02.011 10.1016/j.vetimm.2007.01.020 10.1016/j.vetpar.2009.02.001 10.1016/j.psj.2019.10.071 10.3382/ps.2007-00383 10.1016/j.exppara.2012.01.013 10.1007/s00430-012-0281-y 10.1128/IAI.70.2.859-868.2002 10.1017/S0031182020001249 10.1111/pim.12113 10.3389/fimmu.2019.00229 10.4049/jimmunol.173.4.2675 10.1016/j.exppara.2012.08.017 10.1186/s12711-018-0433-7 10.3389/fimmu.2020.558341 10.3389/fimmu.2013.00289 10.1016/j.molimm.2018.05.023 10.4110/in.2018.18.e11 10.4049/jimmunol.176.3.1840 10.1016/j.imbio.2011.08.008 10.1016/j.chom.2011.07.009 10.1111/j.1462-5822.2011.01597.x 10.1002/pmic.200900305 10.1093/bioinformatics/btw354 10.1093/bioinformatics/btu170 10.1093/bioinformatics/bts635 10.1093/bioinformatics/btu638 10.1080/03079450701802248
BMC Genomics; Sandholt AKS, Wattrang E et. al.

Sep 16th, 2021 - Coccidiosis is an infectious disease with large negative impact on the poultry industry worldwide. It is an enteric infection caused by unicellular Apicomplexan parasites of the genus Eimeria. The present study aimed to gain more knowledge about interactions between parasites and the host immune system during the early asexual replication phase of E. tenella in chicken caeca. For this purpose, ...

Genome-wide association study reveals the genetic architecture of root hair length in m...
https://doi.org/10.1186/s12864-021-07961-z 10.1093/jxb/erp219 10.1199/tab.0172 10.1016/S1360-1385(99)01551-4 10.1093/jxb/erw115 10.1242/dev.132845 10.1016/j.semcdb.2017.10.003 10.1006/dbio.1997.8813 10.3389/fpls.2015.01163 10.1371/journal.pgen.1002446 10.1111/jipb.12077 10.1104/pp.15.00158 10.1111/nph.14160 10.1104/pp.18.01002 10.1111/j.1365-313X.2011.04533.x 10.1104/pp.106.091546 10.1007/s00425-013-1838-8 10.1007/s11103-013-0033-4 10.1104/pp.15.00736 10.1104/pp.105.062174 10.1111/j.1365-313X.2008.03459.x 10.1111/tpj.12578 10.1111/tpj.14200 10.1111/pbi.13290 10.1016/j.copbio.2006.02.003 10.1038/nature08800 10.1038/ng.1018 10.1073/pnas.1120813109 10.1126/science.1177837 10.1038/ng.747 10.1534/g3.112.005066 10.1038/ng.3636 10.1007/s00438-019-01631-2 10.1007/s00122-019-03492-0 10.1111/pbi.13541 10.1007/s11032-010-9500-7 10.1038/ng.2484 10.1111/pbi.12712 10.1186/s12864-015-1874-9 10.1111/tpj.14282 10.1038/ng1702 10.1038/ng.546 10.1093/aob/mch056 10.1016/j.tplants.2003.11.003 10.1146/annurev-arplant-042811-105501 10.1073/pnas.0812346106 10.1093/mp/ssq015 10.1126/science.1195211 10.1105/tpc.16.00790 10.1073/pnas.1613499114 10.1016/j.cub.2018.01.023 10.1073/pnas.1816991115 10.1002/1873-3468.13292 10.1016/j.cub.2018.07.078 10.1073/pnas.1005366107 10.1016/j.molp.2019.12.014 10.1111/nph.16497 10.1093/emboj/20.11.2779 10.1104/pp.013052 10.1016/j.cub.2019.04.059 10.1105/tpc.111.089748 10.1093/pcp/pcg043 10.1093/pcp/pcg119 10.1073/pnas.0503023102 10.1111/pbi.12589 10.1016/j.plantsci.2015.07.017 10.1093/jxb/eru014 10.1111/j.1365-3040.1996.tb00386.x 10.1104/pp.125.4.1679 10.1093/jxb/ern195 10.1105/tpc.108.063099 10.1111/pce.12362 10.1093/jxb/erv436 10.1105/tpc.105.038653 10.1104/pp.105.068809 10.1016/j.pbi.2017.09.007 10.1016/j.pbi.2008.03.008 10.1073/pnas.1406073111 10.1016/j.jmb.2016.05.021 10.1093/glycob/cww054 10.1016/j.plipres.2004.09.002 10.1111/j.1365-313X.2007.03374.x 10.1016/j.molp.2016.06.016 10.1007/s00439-011-1118-2 10.1086/519795
BMC Genomics; Liu L, Jiang LG et. al.

Sep 16th, 2021 - Root hair, a special type of tubular-shaped cell, outgrows from root epidermal cell and plays important roles in the acquisition of nutrients and water, as well as interactions with biotic and abiotic stress. Although many genes involved in root hair development have been identified, genetic basis of natural variation in root hair growth has never been explored. Here, we utilized a maize associ...

PathFams: statistical detection of pathogen-associated protein domains.
https://doi.org/10.1186/s12864-021-07982-8 10.1128/mSystems.00162-19 10.1038/s41598-016-0028-x 10.1006/jmbi.1999.3054 10.1093/nar/gku947 10.1093/nar/gkq1189 10.1093/nar/gkt1223 10.1126/science.1107851 10.1371/journal.pcbi.1000798 10.1016/j.cell.2016.03.016 10.1073/pnas.1215210110 10.3389/fgene.2015.00234 10.1038/s41598-018-37647-8 10.4161/viru.25180 10.1371/journal.pntd.0004403 10.1186/1471-2164-15-392 10.1038/s41588-017-0012-9 10.1093/nar/gkw1017 10.1093/nar/gkv401 10.1016/j.febslet.2014.12.018 10.1016/j.chom.2017.12.018 10.1093/nar/gkz246 10.1177/0300985813511131 10.1371/journal.pone.0201198 10.1128/JB.01465-08 10.1128/JB.187.16.5520-5527.2005 10.1038/35089000 10.1093/bioinformatics/btu681 10.1128/AAC.01587-05 10.1038/ncomms9141 10.1093/bioinformatics/btaa1105 10.1128/JB.183.15.4588-4598.2001 10.1038/s41467-017-00599-0 10.1038/s41467-020-14306-z 10.1038/nature11450 10.1038/nature13568 10.1038/nmeth.1923 10.1093/bioinformatics/btv033 10.1371/journal.pbio.0050077 10.1093/bioinformatics/btl158 10.1038/nature08821
BMC Genomics; Lobb B, Tremblay BJ et. al.

Sep 16th, 2021 - A substantial fraction of genes identified within bacterial genomes encode proteins of unknown function. Identifying which of these proteins represent potential virulence factors, and mapping their key virulence determinants, is a challenging but important goal. To facilitate virulence factor discovery, we performed a comprehensive analysis of 17,929 protein domain families within the Pfam data...

Genomic variation in captive deer mouse (Peromyscus maniculatus) populations.
https://doi.org/10.1186/s12864-021-07956-w 10.7554/eLife.06813 10.1089/vbz.2010.0255 10.1073/pnas.180197197 10.1086/382594 10.1186/s13071-015-0903-5 10.1016/j.semcdb.2016.06.015 10.1016/j.semcdb.2016.06.021 10.1371/journal.pgen.1008420 10.1126/science.1236862 10.1242/dmm.037242 10.1038/nature22074 10.1002/wdev.132 10.1016/j.yhbeh.2017.12.010 10.1073/pnas.0910672106 10.1038/nature08250 10.1007/s00335-014-9500-8 10.1126/sciadv.aaw6441 10.1111/1755-0998.13155 10.1126/science.1058040 10.1101/gr.213660.116 10.1007/s00335-018-9754-7 10.1093/nar/gky1113 10.1186/s13104-016-2072-9 10.1007/s12177-009-9046-2 10.1002/0471250953.bi1110s43 10.4161/fly.19695 10.1186/s12859-014-0356-4 10.1371/journal.pone.0037558 10.1186/1471-2105-14-289 10.1086/316697 10.1186/gb-2007-8-9-r180 10.1016/S1074-7613(01)00085-1 10.1006/jmbi.2000.3514 10.1038/cdd.2008.12 10.1016/S0092-8674(02)00872-3 10.1016/j.peptides.2010.07.020 10.1074/jbc.M312623200 10.1016/j.gde.2020.02.017 10.1016/S0092-8674(01)00571-2 10.1186/s13059-016-1024-y 10.1172/JCI25614
BMC Genomics; Lucius MD, Ji H et. al.

Sep 16th, 2021 - Deer mice (genus Peromyscus) are the most common rodents in North America. Despite the availability of reference genomes for some species, a comprehensive database of polymorphisms, especially in those maintained as living stocks and distributed to academic investigators, is missing. In the present study we surveyed two populations of P. maniculatus that are maintained at the Peromyscus Genetic...

Genome collinearity analysis illuminates the evolution of donkey chromosome 1 and horse...
https://doi.org/10.1186/s12864-021-07984-6 10.1159/000130862 10.1126/science.7375922 10.1016/0888-7543(90)90292-3 10.1053/beha.2001.0159 10.1007/s10577-007-1201-7 10.1093/biohorizons/hzq009 10.1159/000109614 10.1073/pnas.1702012114 10.1186/s13059-018-1544-8 10.1038/s42003-018-0199-z 10.1126/sciadv.aaq0392 10.1007/s10577-013-9346-z 10.1023/B:CHRO.0000009298.02689.8a 10.1126/science.1096008 10.1073/pnas.0709692105 10.1023/A:1026707002538 10.2305/IUCN.UK.2015-2.RLTS.T7949A45170994.en 10.1101/gr.138487.112 10.1073/pnas.1308998110 10.24272/j.issn.2095-8137.2019.042 10.1093/oxfordjournals.jhered.a110118 10.1093/biolreprod/52.monograph_series1.273 10.1111/j.1439-0388.2006.00615.x 10.1038/hdy.1989.54 10.1038/s41467-020-19813-7 10.1126/science.aal3327 10.1159/000235932 10.1023/A:1018408811881 10.1038/srep14106 10.1159/000445459 10.1159/000063050 10.1073/pnas.1412627111 10.1038/nature14249 10.1111/j.1439-0388.2005.00494.x 10.1159/000245916 10.1159/000075753 10.7717/peerj.4958 10.1093/bioinformatics/btq033 10.1093/bioinformatics/btt086 10.1007/978-1-4939-9173-0_14 10.1007/s00224-005-1269-4 10.1093/bioinformatics/btx527 10.1186/s13059-019-1832-y 10.1101/gr.2289704
BMC Genomics; Li S, Zhao G et. al.

Sep 16th, 2021 - It is important to resolve the evolutionary history of species genomes as it has affected both genome organization and chromosomal architecture. The rapid innovation in sequencing technologies and the improvement in assembly algorithms have enabled the creation of highly contiguous genomes. DNA Zoo, a global organization dedicated to animal conservation, offers more than 150 chromosome-length g...

Dysregulation of ribosome-related genes in ankylosing spondylitis: a systems biology ap...
https://doi.org/10.1186/s12891-021-04662-2 10.1038/s41413-019-0057-8 10.22631/rr.2017.69997.1032 10.1002/art.1780401015 10.1136/ard.2010.140574 10.1038/gene.2017.11 10.1097/BOR.0000000000000471 10.1186/s13059-016-1104-z 10.1038/s41389-018-0044-8 10.1111/liv.12155 10.1186/1741-7015-11-98 10.1186/s12885-018-4178-z 10.1186/ar3309 10.1093/nar/gkv007 10.1002/jcb.26546 10.1073/pnas.0506580102 10.1093/bioinformatics/btu170 10.1038/nmeth.3317 10.1038/nmeth.4197 10.1186/s13059-014-0550-8 10.1002/art.1780270401 10.3390/cells8010055 10.1093/jmcb/mjv014 10.1242/dmm.020529 10.1016/j.febslet.2014.03.024 10.1038/nrc1015 10.1016/j.bbrc.2014.06.036 10.1016/j.redox.2018.08.016 10.1016/j.yexcr.2004.02.009 10.1038/onc.2017.86 10.18632/oncotarget.19383 10.1016/0165-2478(89)90152-1 10.1111/j.1365-2567.2010.03258.x 10.1002/art.39464 10.4238/2015.May.18.6 10.1007/s00296-014-3178-9 10.1161/CIRCULATIONAHA.112.125971 10.1111/bjh.15701 10.1126/science.1259077 10.1038/nri3772 10.1016/S0171-2985(11)80413-4 10.1093/gbe/evw257 10.1093/nar/25.9.1788 10.1186/1471-2148-10-70 10.1016/j.ajhg.2009.04.017 10.1016/j.bbadis.2015.02.007 10.1016/B978-0-12-802208-5.00012-6 10.1261/rna.2658311 10.7554/eLife.00762 10.1038/s41590-017-0005-y 10.1186/s13148-019-0632-2 10.1186/s13075-019-1922-y 10.7554/eLife.49551 10.1046/j.1432-0436.2003.7106002.x 10.1002/jor.20706 10.3892/ol.2017.6368 10.1007/s11926-012-0270-6 10.1186/s13075-016-1052-8 10.1097/MAJ.0b013e3182514059
BMC Musculoskeletal Disorders; Lari A, Pourbadie HG et. al.

Sep 16th, 2021 - Ankylosing spondylitis (AS) is an autoimmune rheumatic disease. Few candidate gene associations have been reported for AS and the current understanding of its pathogenesis remains still poor. Thus, the exact mechanism of AS is needed to urgently be disclosed. The purpose of this study was to identify candidate genes involving in AS disease. GSE25101 publicly available microarray and GSE117769 R...

Comprehensive analysis of angiogenesis subtype of squamous cell carcinoma.
https://doi.org/10.1186/s12957-021-02367-3 10.1016/j.ccell.2016.04.004 10.1172/JCI72589 10.1200/JCO.2008.18.1370 10.1038/onc.2014.216 10.1186/s12957-018-1308-7 10.1186/s12957-020-1792-4 10.1186/s12957-018-1375-9 10.1186/s12957-021-02190-w 10.1186/s12957-017-1279-0 10.1186/s12957-017-1221-5 10.1186/s12957-018-1378-6 10.1186/s12957-020-02028-x 10.1016/j.cell.2018.03.022 10.3126/kumj.v13i2.16796 10.4103/0973-1482.163693 10.2174/1566524033479465 10.1177/10454411990100020301 10.1073/pnas.0506580102 10.1016/j.immuni.2018.03.023 10.1038/nbt.2203 10.1007/s10456-017-9562-9 10.1038/nmeth.3337 10.1007/978-1-4939-7493-1_12 10.1038/ncomms3612 10.1158/1078-0432.CCR-18-4085 10.1007/s10456-018-9613-x 10.1055/s-2002-39653 10.1038/nrm3758 10.1158/0008-5472.CAN-13-2032 10.1038/nature07205 10.1111/1346-8138.12314 10.1016/j.critrevonc.2018.06.006 10.1038/nrc3239 10.1155/2015/191832
World Journal of Surgical Oncology; Qin F, Lin S et. al.

Sep 16th, 2021 - Squamous cell carcinoma (SCC) is a disease with distinct management complexities as it displays a remarkably heterogeneous molecular subtype. However, the landscape of angiogenesis for SCC is not fully investigated. The angiogenesis-related subtypes of SCC were established by using the ConsensusClusterPlus package based on angiogenesis-related genes and TCGA data. We analyzed the alteration of ...

Gene co-expression network analysis in zebrafish reveals chemical class specific modules.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438978
BMC Genomics; Shankar P, McClure RS et. al.

Sep 15th, 2021 - Zebrafish is a popular animal model used for high-throughput screening of chemical hazards, however, investigations of transcriptomic mechanisms of toxicity are still needed. Here, our goal was to identify genes and biological pathways that Aryl Hydrocarbon Receptor 2 (AHR2) Activators and flame retardant chemicals (FRCs) alter in developing zebrafish. Taking advantage of a compendium of phenot...

DPYSL2 as potential diagnostic and prognostic biomarker linked to immune infiltration i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439091
World Journal of Surgical Oncology; Wu YJ, Nai AT et. al.

Sep 15th, 2021 - Dihydropyrimidinase like 2 (DPYSL2) has been linked to tumor metastasis. However, the function of DPSY2L in lung adenocarcinoma (LUAD) is yet to be explored. Herein, we assessed DPYSL2 expression in various tumor types via online databases such as Oncomine and Tumor Immune Estimation Resource (TIMER). Further, we verified the low protein and mRNA expressions of DPYSL2 in LUAD via the ULCAN, The...

Stage 4 pancreatic adenocarcinoma harbouring an FGFR2-TACC2 fusion mutation with comple...
https://doi.org/10.1136/bcr-2021-244271
BMJ Case Reports; Poon D, Tan MH et. al.

Sep 14th, 2021 - We report a case of a frail 68-year-old woman with stage 4 pancreatic carcinoma harbouring a fibroblastic growth factor receptor 2 (FGFR2) fusion who achieved a durable complete response after treatment with erdafitinib a pan-FGFR inhibitor. The FGFR2-TACC2 fusion was detected on comprehensive tumour somatic mutation profiling. There is ongoing complete response at 10 months after initiation of...

Integrative analysis of ferroptosis-related genes in ulcerative colitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442491
The Journal of International Medical Research; Cui DJ, Chen C et. al.

Sep 14th, 2021 - The aim of this study was to identify and validate ferroptosis-related markers in ulcerative colitis (UC) to explore new directions for UC diagnosis and treatment. We screened UC chips and ferroptosis-related genes from the Gene Expression Omnibus (GEO), FerrDb, and GeneCards databases. The differentially expressed genes (DEGs) and ferroptosis-related DEGs between the UC group and normal contro...

Morphological characteristics and transcriptome analysis at different anther developmen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436512
BMC Genomics; Wang J, Yang Y et. al.

Sep 14th, 2021 - The discovery of male sterile materials is of great significance for the development of plant fertility research. Wucai (Brassica campestris L. ssp. chinensis var. rosularis Tsen) is a variety of non-heading Chinese cabbage. There are few studies on the male sterility of wucai, and the mechanism of male sterility is not clear. In this study, the male sterile mutant MS7-2 and the wild-type ferti...

Complete genome sequence and identification of polyunsaturated fatty acid biosynthesis ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436480
BMC Genomics; Pal S, Sharma G et. al.

Sep 14th, 2021 - Myxobacteria harbor numerous biosynthetic gene clusters that can produce a diverse range of secondary metabolites. Minicystis rosea DSM 24000T is a soil-dwelling myxobacterium belonging to the suborderSorangiineae and family Polyangiaceae and is known to produce various secondary metabolites as well as polyunsaturated fatty acids (PUFAs). Here, we use whole-genome sequencing to explore the dive...

Integrated analysis of lncRNA and mRNA in liver of Megalobrama amblycephala post Aeromo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435129
BMC Genomics; Sun Q, Wang J et. al.

Sep 14th, 2021 - As non-coding RNA molecules of more than 200 bp in length, long non-coding RNAs (lncRNAs) play a variety of roles in biological processes, including regulating the immune responses to bacterial infections. In recent years, there have been many in-depth studies on mammalian lncRNAs, but the relevant studies in fish are very limited. Meanwhile, since lncRNAs are not conserved among species, it is...

Genome-resolved metagenome and metatranscriptome analyses of thermophilic composting re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434746
BMC Genomics; Braga LPP, Pereira RV et. al.

Sep 12th, 2021 - Composting is an important technique for environment-friendly degradation of organic material, and is a microbe-driven process. Previous metagenomic studies of composting have presented a general description of the taxonomic and functional diversity of its microbial populations, but they have lacked more specific information on the key organisms that are active during the process. Here we prese...

Comprehensive analysis of the cancer driver genes in breast cancer demonstrates their r...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434726
World Journal of Surgical Oncology; Du XW, Li G et. al.

Sep 12th, 2021 - Breast cancer is the most common malignancy in women. Cancer driver gene-mediated alterations in the tumor microenvironment are critical factors affecting the biological behavior of breast cancer. The purpose of this study was to identify the expression characteristics and prognostic value of cancer driver genes in breast cancer. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) ...

Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting mi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434718
Journal of Translational Medicine; Shen HY, Shi LX et. al.

Sep 12th, 2021 - Lung adenocarcinoma (LUAD) is a common subtype of lung cancer with high recurrence rate and fatality. Circ_0001361 has been recognized as key regulators in various malignancies, but its roles in LUAD remain ambiguous. Circ_0001361, miR-525-5p, and VMA21 levels were assessed by RT-qPCR. The growth and metastasis of LUAD cells were detected by MTT, colony formation, wound scratch, and transwell a...

Platelet transcriptome profiles provide potential therapeutic targets for elderly acute...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431913
Journal of Translational Medicine; Bao J, Zhao X et. al.

Sep 12th, 2021 - Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with a median age of 68 in clinical diagnosis. About 60% patients are over 60 years old. There are various treatment options for AML patients. But for elderly patients, the complete remission rates are disappointing due to genetic, molecular, and age-related factors. Development of next-generation sequencing technologies ...