×
About 2,374,513 results

Characterization of the Immune Microenvironmental Landscape of Lung Squamous Cell Carci...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674995
Disease Markers; Chen C, Tang D et. al.

Nov 23rd, 2022 - Increasing evidence supports that immune cell infiltration (ICI) patterns play a key role in the tumor progression of lung squamous cell carcinoma (LUSC). However, to date, the immune infiltration picture of LUSC has not been elucidated. TCGA was used to download multiomics data from LUSC samples. At the same time, we included two datasets on lung squamous cell carcinoma, GSE17710 and GSE157010...

Coexpression Network Analysis-Based Identification of Critical Genes Differentiating be...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674975
Disease Markers; Chen L, Hua J et. al.

Nov 23rd, 2022 - Three Gene Expression Omnibus (GEO) microarray datasets (GSE19491, GSE98461, and GSE152532) were downloaded, with GSE19491 and GSE98461 then being merged to form a training dataset. Hub genes capable of differentiating between ATB and LTBI were then identified through differential expression analyses and a WGCNA analysis of this training dataset. Receiver operating characteristic (ROC) curves w...

Differential Expression of Serum Proteins in Chronic Obstructive Pulmonary Disease Asse...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675428
International Journal of Chronic Obstructive Pulmonary Di... Li R, Zhao X et. al.

Nov 23rd, 2022 - As a common respiratory disease, chronic obstructive pulmonary disease (COPD) has a high morbidity and mortality. Current clinical therapies are not ideal and do not improve lung function or long-term life quality. It is very important to find new potential pathogenic mechanisms, biomarkers, and targets with therapeutic value in COPD. Serum samples collected from acute exacerbation and stable C...

LncRNA TM4SF19-AS1 exacerbates cell proliferation, migration, invasion, and EMT in head...
https://doi.org/10.1080/15384047.2022.2116923
Cancer Biology & Therapy; Yu Z, Wang X et. al.

Nov 23rd, 2022 - Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous and aggressive tumor with high mortality and unfavorable prognosis. Numerous long non-coding RNAs (lncRNAs) have been confirmed to exert pivotal parts in cancers. Nevertheless, the functions of most lncRNAs in HNSCC need deeper exploration. Our present research tried to clarify the biological role of TM4SF19 antisense RNA 1 (TM4SF...

hsa-miR-320a-3p and hsa-miR-483-5p levels in human granulosa cells: promising bio-marke...
https://doi.org/10.1186/s12958-022-01037-7
Reproductive Biology and Endocrinology : RB&E; Liu Y, Mei Q et. al.

Nov 22nd, 2022 - MicroRNAs (miRNAs) are considered potential biomarkers for various diseases. This study investigated whether hsa-miR-320a-3p and hsa-miR-483-5p levels in human ovarian granulosa cells derived from follicular fluids are associated with embryo developmental competence. We collected 195 granulosa cells samples and analyzed the treatment outcomes in patients undergoing in vitro fertilization (n = 1...

SLIT2 promoter hypermethylation predicts disease progression in chronic myeloid leukemia.
https://doi.org/10.1186/s40001-022-00899-2
European Journal of Medical Research; Wu DL, Wang Y et. al.

Nov 22nd, 2022 - Aberrant DNA methylation plays a crucial role in the progression of myeloid neoplasms. Previously, our literature reported that slit guidance ligand 2 (SLIT2) promoter methylation was associated with disease progression and indicated a poor prognosis in patients with myelodysplastic syndrome. Herein, we further investigated the clinical implications and role of SLIT2 promoter methylation in pat...

OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carci...
https://doi.org/10.1186/s13046-022-02533-9
Journal of Experimental & Clinical Cancer Research : CR; Di M, Miao J et. al.

Nov 22nd, 2022 - Radioresistance is the primary cause of nasopharyngeal carcinoma (NPC) treatment failure. Previous studies have focused on the deficits in cellular apoptosis as a mechanism for radioresistance; however, additional potential death modes involved in modulating radiosensitivity of NPC have not been explored. Pyroptosis was assessed by phase-contrast imaging, LDH release assays, live cell imaging, ...

Modifiable risk factors for intracranial aneurysms: Evidence from genetic studies.
https://doi.org/10.1177/17474930211065640
International Journal of Stroke : Official Journal of The... Sun X, Liu B et. al.

Nov 22nd, 2022 - Intracranial aneurysm (IA) is a crucial health concern with limited strategies for prevention and treatment. To identify potentially modifiable risk factors, such as socioeconomic, behaviors, dietary, and cardiometabolic factors, for IA and its subtypes. Summary statistics for IA were derived from a genome-wide association study with an overall 79,429 participants. Single nucleotide polymorphis...

The association of arterial stiffness index with cerebrovascular and cardiometabolic di...
https://doi.org/10.1177/17474930211066432
International Journal of Stroke : Official Journal of The... Liu W, Zhang L et. al.

Nov 22nd, 2022 - Arterial stiffness index (ASI) is a potential risk factor for cerebrovascular and cardiometabolic diseases, but the causal links between them are inconclusive. The aim is to evaluate the causal effects of ASI on cerebrovascular and cardiometabolic diseases by Mendelian randomization (MR). Two-sample MR analysis was performed to infer causal links. Genetic variants significantly associated with ...

Transcriptome analysis reveals the regulatory mode by which NAA promotes the growth of ...
https://doi.org/10.1371/journal.pone.0277701
PloS One; Cai J, Chen B et. al.

Nov 22nd, 2022 - A symbiotic relationship is observed between Armillaria and the Chinese herbal medicine Gastrodia elata (G. elata). Armillaria is a nutrient source for the growth of G. elata, and its nutrient metabolism efficiency affects the growth and development of G. elata. Auxin has been reported to stimulate Armillaria species, but the molecular mechanism remains unknown. We found that naphthalene acetic...

48-Week effectiveness and tolerability of dolutegravir (DTG) + lamivudine (3TC) in anti...
https://doi.org/10.1371/journal.pone.0277606
PloS One; Cabello-Ubeda A, de Quirós JCLB et. al.

Nov 22nd, 2022 - The main international guidelines indicate DTG/3TC therapy as one of the preferred regimens for people living with HIV (PLWH), due to its observed efficacy in randomized clinical trials. However, information in real-life cohorts is relatively scarce for first-line use. A retrospective multicenter study of adult PLWH starting DTG+3TC as a first-line regimen before January 31st, 2020. Virological...

Evaluation of compressed sodium chloride on the inactivation of SARS-CoV-2 and surrogates.
https://doi.org/10.1371/journal.pone.0277881
PloS One; Bhavanam S, Lee B et. al.

Nov 22nd, 2022 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the global COVID-19 pandemic. Limited studies have been performed on various types of disinfectants utilized to control the spread of this highly contagious virus. This study aimed to investigate the inactivation of SARS-CoV-2 using compressed sodium chloride (CSC) surface. A real-time reverse transcriptase quantitative PCR (RT...

Interneurons of fan-shaped body promote arousal in Drosophila.
https://doi.org/10.1371/journal.pone.0277918
PloS One; Kato YS, Tomita J et. al.

Nov 22nd, 2022 - Sleep is required to maintain physiological functions and is widely conserved across species. To understand the sleep-regulatory mechanisms, sleep-regulating genes and neuronal circuits are studied in various animal species. In the sleep-regulatory neuronal circuits in Drosophila melanogaster, the dorsal fan-shaped body (dFB) is a major sleep-promoting region. However, other sleep-regulating ne...

Molecular and microbiological evidence of bacterial contamination of intraocular lenses...
https://doi.org/10.1371/journal.pone.0277753
PloS One; Dowler KK, Vientós-Plotts A et. al.

Nov 22nd, 2022 - Inflammatory outcomes, including toxic anterior segment syndrome (TASS) and infectious endophthalmitis, are potentially painful, blinding complications following cataract surgery. In an in vitro pilot study, commercially available, sterile foldable intraocular lenses (IOLs) used during routine canine cataract surgery, and their packaging fluid were surveyed for the presence of bacterial DNA and...

Papain ameliorates monocyte-platelet aggregate formation-mediated inflammatory response...
https://doi.org/10.1371/journal.pone.0278059
PloS One; Jiang L, Xu C et. al.

Nov 22nd, 2022 - MicroRNA-146a (miRNA-146a) is a nuclear factor κB (NF-κB)-inducible and inflammation-sensitive miRNA, while papain elicits anti-inflammatory effects by inhibiting monocyte-platelet aggregate (MPA)-mediated NF-κB pathway activation in monocytes. This study aimed to demonstrate the underlying effects of papain on MPA formation-initiated miRNA-146a expression and subsequent action in monocytes. TH...

Solitary Involvement of the Liver: A Rare Manifestation of Langerhans Cell Histiocytosis.
https://doi.org/10.12659/AJCR.937628
The American Journal of Case Reports; Consing M, Lee HE et. al.

Nov 22nd, 2022 - BACKGROUND Langerhans cell histiocytosis (LCH) is a rare condition caused by a neoplastic proliferation of myeloid cells. It can present as a single-system or multi-system disorder. Worse prognosis is associated with the hematopoietic system (spleen, liver, bone marrow), which is routinely observed in multi-system disease. Because of the varied presentation of this disorder, diagnosis can be di...

Identification of Malassezia globosa as a Gastric Fungus Associated with PD-L1 Expressi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669766
Journal of Immunology Research; Zhang Z, Qiu Y et. al.

Nov 22nd, 2022 - Microbiotas affected the prognosis of cancer patients by regulating programmed death ligand-1 (PD-L1) expression. However, the relationship between gastric fungi and PD-L1 expression is still unclear in gastric cancer (GC). We aimed at exploring the association of gastric fungi with PD-L1 expression and overall survival in GC. A total of 61 GC patients were divided into the two groups based on ...

Comprehensive Analysis Reveals PTK6 as a Prognostic Biomarker Involved in the Immunosup...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668476
Journal of Immunology Research; Wang L, Luo S et. al.

Nov 22nd, 2022 - The significant mortality rate that is currently experienced by female breast cancer (BC) patients highlights the importance of locating potent and dependable biomarkers in BC patients. Over the past few years, a number of studies have demonstrated that PTK6 was dysregulated in a variety of cancers. However, its expression and the clinical importance it may have in patients with BC have not bee...

Anterior Gradient 2 is a Significant Prognostic Biomarker in Bone Metastasis of Breast ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668893
Pathology Oncology Research : POR; Li JJ, Wang S et. al.

Nov 22nd, 2022 - Background: The study aimed to detect DEGs associated with BRCA bone metastasis, filter prognosis biomarkers, and explore possible pathways. Methods: GSE175692 dataset was used to detect DEGs between BRCA bone metastatic cases and non-bone metastatic cases, followed by the construction of a PPI network among DEGs. The main module among the PPI network was then determined and pathway analysis on...

Interleukin-27 Ameliorates Atherosclerosis in ApoE-/- Mice through Regulatory T Cell Au...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674420
Mediators of Inflammation; Xu W, Zhu R et. al.

Nov 22nd, 2022 - Atherosclerosis, which is characterized by chronic inflammation in the arterial wall, is driven by immune cells and cytokines. Recent evidence indicated that interleukin (IL)-27 showed pleiotropic properties in immune diseases. However, precise mechanisms of IL-27, especially in atherosclerosis remains unknown. In our research, we examined the influence of the administration of IL-27 and an ant...