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About 793,558 results

COVID-19 vaccination and treatment in vulnerable populations.
https://doi.org/10.1111/imm.13445
Immunology Delgoffe GM

Jan 13th, 2022 - COVID-19 vaccination and treatment in vulnerable populations.|2022|Delgoffe GM,|epidemiology,immunology,prevention & control,administration & dosage,immunology,immunology,

CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory...
https://doi.org/10.1084/jem.20211191
The Journal of Experimental Medicine; Zhang B, Zhang Y et. al.

Jan 12th, 2022 - Inflammatory monocytes are key mediators of acute and chronic inflammation; yet, their functional diversity remains obscure. Single-cell transcriptome analyses of human inflammatory monocytes from COVID-19 and rheumatoid arthritis patients revealed a subset of cells positive for CD127, an IL-7 receptor subunit, and such positivity rendered otherwise inert monocytes responsive to IL-7. Active IL...

COVID-19 Vaccine Focused on T-Cell Response Promising in Early Trial.
https://doi.org/10.1001/jama.2021.24118
JAMA Abbasi J

Jan 12th, 2022 - COVID-19 Vaccine Focused on T-Cell Response Promising in Early Trial.|2022|Abbasi J,|prevention & control,immunology,immunology,

Homing In On a SARS-CoV-2 Correlate of Protection.
https://doi.org/10.1001/jama.2021.24117
JAMA Abbasi J

Jan 12th, 2022 - Homing In On a SARS-CoV-2 Correlate of Protection.|2022|Abbasi J,|immunology,prevention & control,immunology,

Immunogenicity of the COVID-19 Two-Vaccination Series Among Hematologic Malignancies: R...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744183
Cancer Control : Journal of the Moffitt Cancer Center; Pasikhova Y, Morrison AR et. al.

Jan 11th, 2022 - Data is limited on the immunogenicity of the COVID-19 two-vaccination series among patients with hematologic malignancies and current guidelines do not recommend routine monitoring for post-vaccine antibodies. However, we describe three patients who developed severe or critical COVID-19 infections six months after vaccination. This highlights the importance of routine testing of COVID-19 IgG Sp...

SARS-CoV-2 Reinfection Rate and Estimated Effectiveness of the Inactivated Whole Virion...
https://doi.org/10.1001/jamanetworkopen.2021.42210
JAMA Network Open; Malhotra S, Mani K et. al.

Jan 8th, 2022 - A surge of COVID-19 occurred from March to June 2021, in New Delhi, India, linked to the B.1.617.2 (Delta) variant of SARS-CoV-2. COVID-19 vaccines were rolled out for health care workers (HCWs) starting in January 2021. To assess the incidence density of reinfection among a cohort of HCWs and estimate the effectiveness of the inactivated whole virion vaccine BBV152 against reinfection. This wa...

Expression of immune response genes in human corneal epithelial cells interacting with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728928
BMC Genomics; Arunachalam D, Ramanathan SM et. al.

Jan 6th, 2022 - Aspergillus flavus, one of the causative agents of human fungal keratitis, can be phagocytosed by human corneal epithelial (HCE) cells and the conidia containing phagosomes mature into phagolysosomes. But the immunological responses of human corneal epithelial cells interacting with A. flavus are not clear. In this study, we report the expression of immune response related genes of HCE cells ex...

Sequential immunization with SARS-CoV-2 RBD vaccine induces potent and broad neutraliza...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724645
Virology Journal; Song S, Zhou B et. al.

Jan 6th, 2022 - The current COVID-19 pandemic caused by constantly emerging SARS-CoV-2 variants still poses a threat to public health worldwide. Effective next-generation vaccines and optimized booster vaccination strategies are urgently needed. Here, we sequentially immunized mice with a SARS-CoV-2 wild-type inactivated vaccine and a heterologous mutant RBD vaccine, and then evaluated their neutralizing antib...

Spectral image contrast-based flow digital nanoplasmon-metry for ultrasensitive antibod...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724237
Journal of Nanobiotechnology; Wang SH, Kuo CW et. al.

Jan 6th, 2022 - Gold nanoparticles (AuNPs) have been widely used in local surface plasmon resonance (LSPR) immunoassays for biomolecule sensing, which is primarily based on two conventional methods: absorption spectra analysis and colorimetry. The low figure of merit (FoM) of the LSPR and high-concentration AuNP requirement restrict their limit of detection (LOD), which is approximately ng to μg mL-1 in antibo...

IgG3 and IgM Identified as Key to SARS-CoV-2 Neutralization in Convalescent Plasma Pools.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726489
PloS One; Kober C, Manni S et. al.

Jan 5th, 2022 - Analysis of convalescent plasma derived from individuals has shown that IgG3 has the most important role in binding to SARS-CoV-2 antigens; however, this has not yet been confirmed in large studies, and the link between binding and neutralization has not been confirmed. By analyzing plasma pools consisting of 247-567 individual convalescent donors, we demonstrated the binding of IgG3 and IgM to...

Hypotheses to explain the associations between asthma and the consequences of COVID-19 ...
https://doi.org/10.1111/cea.14021
Clinical and Experimental Allergy : Journal of the Britis... Warner JO, Warner JA et. al.

Jan 4th, 2022 - Hypotheses to explain the associations between asthma and the consequences of COVID-19 infection.|2022|Warner JO,Warner JA,Munblit D,|complications,immunology,complications,immunology,immunology,immunology,

Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody cli...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719770
PloS One; Issafras H, Fan S et. al.

Jan 1st, 2022 - Cancer immunotherapies, such as checkpoint blockade of programmed cell death protein-1 (PD-1), represents a breakthrough in cancer treatment, resulting in unprecedented results in terms of overall and progression-free survival. Discovery and development of novel anti PD-1 inhibitors remains a field of intense investigation, where novel monoclonal antibodies (mAbs) and novel antibody formats (e....

Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody r...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719683
PloS One; Berendam SJ, Morgan-Asiedu PK et. al.

Jan 1st, 2022 - Different HIV vaccine regimens elicit distinct plasma antibody responses in both human and nonhuman primate models. Previous studies in human and non-human primate infants showed that adjuvants influenced the quality of plasma antibody responses induced by pediatric HIV envelope vaccine regimens. We recently reported that use of the 3M052-SE adjuvant and longer intervals between vaccinations ar...

Development of an Automatic Measurement Method for CD8 and PD-1 Positive T Cells Using ...
https://doi.org/10.21873/anticanres.15500
Anticancer Research; Miyata H, Akiyama Y et. al.

Jan 1st, 2022 - With the progress in cancer immunotherapy using immune checkpoint blockade (ICB) therapy, histological observations of tumor-infiltrating lymphocyte (TIL) status are needed to evaluate the antitumor effect of ICB using imaging analysis software. Formalin-fixed paraffin-embedded sections obtained from colorectal cancer and gastric cancer patients with more than 500 single nucleotide variants wer...

CD15+ Bone Marrow-derived Cells Are Regulators of Immune Response in ARG1-producing Col...
https://doi.org/10.21873/anticanres.15504
Anticancer Research; Miyoshi K, Sato E et. al.

Jan 1st, 2022 - Bone marrow-derived cells regulate the antitumor functions of tumor infiltrating lymphocytes (TILs) through arginase 1 (ARG1)-dependent metabolism. This study examines which ARG1-producing lineage is responsible for the inhibitory function of TILs. Multiplexed immunohistochemistry was performed for CD11b, CD163, CD68, and CD15, together with ARG1 expression and CD3+ TIL infiltration estimation ...

Epstein-Barr Virus-induced Gene 3 as a Novel Biomarker in Metastatic Melanoma With Infi...
https://doi.org/10.21873/anticanres.15509
Anticancer Research; Yonekura S

Jan 1st, 2022 - Epstein-Barr virus-induced gene 3 (EBI3) is an immunomodulatory protein-coding gene. So far, the prognostic role of EBI3 in human metastatic melanoma has been unclear. This study aimed to evaluate the EBI3 expression as a potential biomarker using the public database with tumor-infiltrating lymphocytes (TILs) data. Survival analyses were performed in the database of The Cancer Genome Atlas (TCG...

Therapeutic Effect of IL-38 on Experimental Autoimmune Uveitis: Reprogrammed Immune Cel...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727319
Investigative Ophthalmology & Visual Science; Li H, Zhu L et. al.

Dec 31st, 2021 - The purpose of this study was to elucidate the effects of interleukin (IL)-38 on experimental autoimmune uveitis (EAU) and its underlying mechanisms. Mice with EAU were treated with IL-38, and the retinas and cervical draining lymph nodes (CDLNs) were analyzed by flow cytometry. Single-cell RNA sequencing (scRNA-seq) was conducted to analyze the immune cell profiles of CDLNs from normal, EAU, a...

Audio Interview: Covid-19 Vaccination and the Omicron Variant.
https://doi.org/10.1056/NEJMe2120098
The New England Journal of Medicine; Rubin EJ, Baden LR et. al.

Dec 30th, 2021 - Audio Interview: Covid-19 Vaccination and the Omicron Variant.|2021|Rubin EJ,Baden LR,Morrissey S,|analogs & derivatives,supply & distribution,therapeutic use,analogs & derivatives,supply & distribution,therapeutic use,immunology,therapeutic use,therapeutic use,therapeutic use,therapeutic use,prevention & control,transmission,administration & dosage,immunology,prevention & control,

Making sense of unfamiliar COVID-19 vaccines: How national origin affects vaccination w...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716032
PloS One; Jensen EA, Wagoner B et. al.

Dec 30th, 2021 - Vaccination willingness is a critical factor in pandemics, including the COVID-19 crisis. Therefore, investigating underlying drivers of vaccination willingness/hesitancy is an essential social science contribution. The present study of German residents investigates the mental shortcuts people are using to make sense of unfamiliar vaccine options by examining vaccination willingness for differe...

Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711287
Molecular Medicine (Cambridge, Mass.); Chapoval SP, Keegan AD

Dec 29th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is critically important to define the immunological processes occurring in the human response to this virus and pathogenetic mechanisms of its deadly ma...