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About 812,115 results

Gloria Choi.
https://doi.org/10.1016/j.neuron.2022.10.011
Neuron

Nov 4th, 2022 - In an interview with Neuron, Gloria Choi gives us an overview of her work to characterize how neural circuits and behaviors are affected after immune challenges in various contexts. We also learn about her unique perspective in marrying the two disciplines of neuroscience and immunology.

Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes.
https://doi.org/10.1038/s41586-022-05388-4
Nature Wang TW, Johmura Y et. al.

Nov 4th, 2022 - The accumulation of senescent cells is a major cause of age-related inflammation and predisposes to a variety of age-related diseases1. However, little is known about the molecular basis underlying this accumulation and its potential as a target to ameliorate the ageing process. Here we show that senescent cells heterogeneously express the immune checkpoint protein programmed death-l...

Nociceptor neurons affect cancer immunosurveillance.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646485
Nature Balood M, Ahmadi M et. al.

Nov 4th, 2022 - Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory peripheral nervous systems1-5. Whether the neo-innervation of tumours by pain-initiating sensory neurons affects cancer immunosurveillance remains unclear. Here we show that melanoma cells interact with nociceptor neurons, leading to increases in their neurite outgrowth, responsiveness to noxious l...

Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617731
Journal of Immunology Research; Lee CYQ, Chan YT et. al.

Nov 2nd, 2022 - Helicobacter pylori colonization and persistence could precede gastric adenocarcinoma. Elucidating immune recognition strategies of H. pylori is therefore imperative to curb chronic persistence in the human host. Toll-like receptor 7 (TLR7) and TLR8 are widely known as viral single-stranded RNA (ssRNA) sensors yet less studied in the bacteria context. Here, we investigated the involvement of th...

Tim-3 downregulation by Toxoplasma gondii infection contributes to decidual dendritic c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615254
Parasites & Vectors; Xie H, Li Z et. al.

Oct 29th, 2022 - Women in early pregnancy infected by Toxoplasma gondii may have severe adverse pregnancy outcomes, such as spontaneous abortion and fetal malformation. The inhibitory molecule T cell immunoglobulin and mucin domain 3 (Tim-3) is highly expressed on decidual dendritic cells (dDCs) and plays an important role in maintaining immune tolerance. However, whether T. gondii infection can cause dDC dysfu...

Human IgG responses to Aedes mosquito salivary peptide Nterm-34kDa and its comparison t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612500
PloS One; Kassam NA, Laswai D et. al.

Oct 28th, 2022 - The level of human exposure to arbovirus vectors, the Aedes mosquitoes, is mainly assessed by entomological methods which are labour intensive, difficult to sustain at a large scale and are affected if transmission and exposure levels are low. Alternatively, serological biomarkers which detect levels of human exposure to mosquito bites may complement the existing epidemiologic tools as they see...

Audio Interview: Assessing the Effect of Vaccination and Prior SARS-CoV-2 Infection.
https://doi.org/10.1056/NEJMe2214027
The New England Journal of Medicine; Rubin EJ, Baden LR et. al.

Oct 28th, 2022 - Audio Interview: Assessing the Effect of Vaccination and Prior SARS-CoV-2 Infection.|2022|Rubin EJ,Baden LR,Morrissey S,|analysis,immunology,immunology,prevention & control,immunology,immunology,therapeutic use,

Immunogenicity and reactogenicity of SARS-CoV-2 vaccines in people living with HIV in t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612532
PLoS Medicine; Hensley KS, Jongkees MJ et. al.

Oct 28th, 2022 - Vaccines can be less immunogenic in people living with HIV (PLWH), but for SARS-CoV-2 vaccinations this is unknown. In this study we set out to investigate, for the vaccines currently approved in the Netherlands, the immunogenicity and reactogenicity of SARS-CoV-2 vaccinations in PLWH. We conducted a prospective cohort study to examine the immunogenicity of BNT162b2, mRNA-1273, ChAdOx1-S, and A...

Functional antibodies exhibit light chain coherence.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607724
Nature Jaffe DB, Shahi P et. al.

Oct 27th, 2022 - The vertebrate adaptive immune system modifies the genome of individual B cells to encode antibodies that bind particular antigens1. In most mammals, antibodies are composed of heavy and light chains that are generated sequentially by recombination of V, D (for heavy chains), J and C gene segments. Each chain contains three complementarity-determining regions (CDR1-CDR3), which contr...

Humoral immune response against BNT162b2 mRNA COVID-19 vaccine in patients with rheumat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592140
Medicine Sugihara K, Wakiya R et. al.

Oct 26th, 2022 - We investigated serum total antibody titers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein receptor-binding domain after BNT162b2 mRNA vaccination against coronavirus disease 2019 (COVID-19) in Japanese patients taking various immunosuppressive medications for rheumatic disease. In 212 outpatients with rheumatic diseases at Kagawa University Hospital and 43 h...

TLR7 controls myeloid-derived suppressor cells expansion and function in the lung of C5...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9591064
PLoS Neglected Tropical Diseases; Zhou L, Zhu Y et. al.

Oct 25th, 2022 - Toll-like receptors (TLRs) play an important role in the induction of innate and adaptive immune responses against Schistosoma japonicum (S. japonicum) infection. However, the role of Toll-like receptor 7 (TLR7) in the mouse lung during S. japonicum infection and the myeloid-derived suppressor cells (MDSCs) affected by the absence of TLR7 are not clearly understood. In this study, the results i...

IFNγ-IL-17+ CD8 T cells contribute to immunosuppression and tumor progression in human ...
https://doi.org/10.1016/j.canlet.2022.215977
Cancer Letters; Lee YH, Chuah S et. al.

Oct 25th, 2022 - IL-17-producing CD8 (Tc17) T cells have been shown to play an important role in infection and chronic inflammation, however their implications in hepatocellular carcinoma (HCC) remain elusive. In this study, we performed cytometry by time-of-flight (CyTOF) and revealed the distinctive immunological phenotypes of two IFNγ+ and IFNγ- Tc17 subsets that were preferentially enriched in human HCC. Si...

Interleukin-33 deficiency prevents biliary injuries and repairments caused by Clonorchi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587592
Parasites & Vectors; Yan C, Xu N et. al.

Oct 23rd, 2022 - Clonorchiasis caused by Clonorchis sinensis is a zoonotic parasitic disease characterized by cholangitis, biliary proliferation, biliary fibrosis, and even cholangiocarcinoma. Our previous study showed that the expression of interleukin (IL)-33 is increased in both humans and mice infected by C. sinensis, suggesting that IL-33 is potentially involved in the pathogenesis of clonorchiasis. Howeve...

The pleiotropic roles of EZH2 in T-cell immunity and immunotherapy.
https://doi.org/10.1007/s12185-022-03466-x
International Journal of Hematology; Wang Y, Bui T et. al.

Oct 23rd, 2022 - EZH2 is a histone methyltransferase. It catalyzes trimethylation of histone H3 at lysine 27 (H3K27me3) to control gene transcription critical for cell proliferation, differentiation, expansion, and function. For instance, EZH2 plays a central role in regulating T-cell immune responses. EZH2 restrains terminal differentiation of effector CD8 T cells, promotes formation of precursor and mature me...

Identification of immune-related mechanisms of cetuximab induced skin toxicity in color...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586384
PloS One; Park JH, Kim MY et. al.

Oct 22nd, 2022 - Skin rash is a well-known predictive marker of the response to cetuximab (Cmab) in metastatic colorectal cancer (mCRC). However, the mechanism of skin rash development is not well understood. Following exposure to EGFR-targeted therapies, changes in IL-8 levels have been reported. The aim of this study was to evaluate the association between skin rash and inflammatory cytokine levels, including...

Evaluation of mRNA-1273 Vaccine in Children 6 Months to 5 Years of Age.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634866
The New England Journal of Medicine; Anderson EJ, Creech CB et. al.

Oct 20th, 2022 - The safety, reactogenicity, immunogenicity, and efficacy of the mRNA-1273 coronavirus disease 2019 (Covid-19) vaccine in young children are unknown. Part 1 of this ongoing phase 2-3 trial was open label for dose selection; part 2 was an observer-blinded, placebo-controlled evaluation of the selected dose. In part 2, we randomly assigned young children (6 months to 5 years of age) in a 3:1 ratio...

Evolution of immune genes is associated with the Black Death.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580435
Nature Klunk J, Vilgalys TP et. al.

Oct 20th, 2022 - Infectious diseases are among the strongest selective pressures driving human evolution1,2. This includes the single greatest mortality event in recorded history, the first outbreak of the second pandemic of plague, commonly called the Black Death, which was caused by the bacterium Yersinia pestis3. This pandemic devastated Afro-Eurasia, killing up to 30-50% of the populat...

Cellular interferon-gamma and interleukin-2 responses to SARS-CoV-2 structural proteins...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576055
PloS One; Sedegah M, Porter C et. al.

Oct 18th, 2022 - Class I- and Class II-restricted epitopes have been identified across the SARS-CoV-2 structural proteome. Vaccine-induced and post-infection SARS-CoV-2 T-cell responses are associated with COVID-19 recovery and protection, but the precise role of T-cell responses remains unclear, and how post-infection vaccination ('hybrid immunity') further augments this immunity To accomplish these goals, we ...

Trim69 is a microtubule regulator that acts as a pantropic viral inhibitor.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618055
Proceedings of the National Academy of Sciences of the Un... Song Y, Nguyen XN et. al.

Oct 18th, 2022 - Through a screen that combines functional and evolutionary analyses, we identified tripartite motif protein (Trim69), a poorly studied member of the Trim family, as a negative regulator of HIV-1 infection in interferon (IFN)-stimulated myeloid cells. Trim69 inhibits the early phases of infection of HIV-1, but also of HIV-2 and SIVMAC in addition to the negative and positive-strand RNA viruses v...

Acute exacerbation in antineutrophil cytoplasmic antibody-associated interstitial lung ...
https://doi.org/10.1016/j.rmed.2022.106992
Respiratory Medicine; Otsuka J, Yoshizawa S et. al.

Oct 18th, 2022 - Acute exacerbation (AE) is a life-threatening clinical event that occurs during the clinical course of idiopathic pulmonary fibrosis (IPF). Several studies have reported that AE also occurs in interstitial lung disease (ILD) other than IPF. However, the incidence, clinical features, risk factors for AE, and major causes of death in antineutrophil cytoplasmic antibody (ANCA)-associated ILD (ANCA...