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About 605,112 results

Effectiveness of a Third Dose of MMR Vaccine for Mumps Outbreak Control.
https://doi.org/10.1056/NEJMoa1703309
The New England Journal of Medicine; Cardemil CV, Dahl RM et. al.

Sep 6th, 2017 - The effect of a third dose of the measles-mumps-rubella (MMR) vaccine in stemming a mumps outbreak is unknown. During an outbreak among vaccinated students at the University of Iowa, health officials implemented a widespread MMR vaccine campaign. We evaluated the effectiveness of a third dose for outbreak control and assessed for waning immunity. Of 20,496 university students who were enrolled ...

Influenza Vaccine Effectiveness in the United States during the 2015-2016 Season.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727917
The New England Journal of Medicine; Jackson ML, Chung JR et. al.

Aug 9th, 2017 - The A(H1N1)pdm09 virus strain used in the live attenuated influenza vaccine was changed for the 2015-2016 influenza season because of its lack of effectiveness in young children in 2013-2014. The Influenza Vaccine Effectiveness Network evaluated the effect of this change as part of its estimates of influenza vaccine effectiveness in 2015-2016. We enrolled patients 6 months of age or older who p...

A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing d...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104022
The Lancet. Neurology; Sabater L, Gaig C et. al.

Apr 7th, 2014 - Autoimmunity might be associated with or implicated in sleep and neurodegenerative disorders. We aimed to describe the features of a novel neurological syndrome associated with prominent sleep dysfunction and antibodies to a neuronal antigen. In this observational study, we used clinical and video polysomnography to identify a novel sleep disorder in three patients referred to the Sleep Unit of...

Antibodies against MERS coronavirus in dromedary camels, Kenya, 1992-2013.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111164
Emerging Infectious Diseases; Corman VM, Jores J et. al.

Jul 30th, 2014 - Dromedary camels are a putative source for human infections with Middle East respiratory syndrome coronavirus. We showed that camels sampled in different regions in Kenya during 1992-2013 have antibodies against this virus. High densities of camel populations correlated with increased seropositivity and might be a factor in predicting long-term virus maintenance.

Screening for hepatitis B virus infection in nonpregnant adolescents and adults: U.S. P...
https://doi.org/10.7326/M14-1018
Annals of Internal Medicine; LeFevre ML,

May 27th, 2014 - Update of the 2004 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for hepatitis B virus (HBV) infection. The USPSTF reviewed the evidence on the benefits and harms of antiviral treatment, the benefits of education or behavior change counseling, and the association between improvements in intermediate and clinical outcomes after antiviral therapy. This recommendation ap...

Needle-free jet injection for administration of influenza vaccine: a randomised non-inf...
https://doi.org/10.1016/S0140-6736(14)60524-9
Lancet (London, England); McAllister L, Anderson J et. al.

Jun 2nd, 2014 - Administration of vaccines by needle-free technology such as jet injection might offer an alternative to needles and syringes that avoids the issue of needle phobia and the risk of needle-stick injury. We aimed to assess the immunogenicity and safety of trivalent influenza vaccine given by needle-free jet injector compared with needle and syringe. For this randomised, comparator-controlled tria...

Efficacy and safety of sublingual tablets of house dust mite allergen extracts in adult...
https://doi.org/10.1016/j.jaci.2013.11.012
The Journal of Allergy and Clinical Immunology; Bergmann KC, Demoly P et. al.

Jan 6th, 2014 - Preliminary studies have suggested the efficacy of sublingual tablets of house dust mite (HDM) extracts in adults with allergic rhinitis. We sought to assess the efficacy and safety of 2 doses of HDM sublingual tablets over 1 treatment year and the subsequent immunotherapy-free year. Adults with HDM-associated allergic rhinitis were randomized in a double-blind, placebo-controlled study to rece...

Secukinumab in plaque psoriasis--results of two phase 3 trials.
https://doi.org/10.1056/NEJMoa1314258
The New England Journal of Medicine; Langley RG, Elewski BE et. al.

Jul 9th, 2014 - Interleukin-17A is considered to be central to the pathogenesis of psoriasis. We evaluated secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe plaque psoriasis. In two phase 3, double-blind, 52-week trials, ERASURE (Efficacy of Response and Safety of Two Fixed Secukinumab Regimens in Psoriasis) and FIXTURE (Full Year Investigative Examination...

Efficacy of dietary interventions for inducing histologic remission in patients with eo...
https://doi.org/10.1053/j.gastro.2014.02.006
Gastroenterology Arias A, González-Cervera J et. al.

Feb 18th, 2014 - Various dietary interventions have been used to treat patients with eosinophilic esophagitis (EoE), yielding varied results. This systematic review assesses the efficacy of different dietary therapies in inducing disease remission. We performed a systematic search of the MEDLINE, EMBASE, and SCOPUS databases for studies investigating the efficacy of dietary interventions (reducing infiltration ...

Sensitization to Hymenoptera venoms is common, but systemic sting reactions are rare.
https://doi.org/10.1016/j.jaci.2013.10.046
The Journal of Allergy and Clinical Immunology; Sturm GJ, Kranzelbinder B et. al.

Dec 24th, 2013 - Sensitization to Hymenoptera venom without systemic sting reactions (SSRs) is commonly observed in the general population. Clinical relevance for a future sting has not yet been investigated. We aimed to evaluate the effect of these debatable sensitizations with deliberate sting challenges and to monitor serologic changes for up to 2 years. One hundred thirty-one challenges with bees and wasps ...

Recommendations for live viral and bacterial vaccines in immunodeficient patients and t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009347
The Journal of Allergy and Clinical Immunology; , Shearer WT et. al.

Mar 3rd, 2014 - The present uncertainty of which live viral or bacterial vaccines can be given to immunodeficient patients and the growing neglect of societal adherence to routine immunizations has prompted the Medical Advisory Committee of the Immune Deficiency Foundation to issue recommendations based on published literature and the collective experience of the committee members. These recommendations addres...

Assessment of second-line antiretroviral regimens for HIV therapy in Africa.
https://doi.org/10.1056/NEJMoa1311274
The New England Journal of Medicine; Paton NI, Kityo C et. al.

Jul 11th, 2014 - The efficacy and toxic effects of nucleoside reverse-transcriptase inhibitors (NRTIs) are uncertain when these agents are used with a protease inhibitor in second-line therapy for human immunodeficiency virus (HIV) infection in resource-limited settings. Removing the NRTIs or replacing them with raltegravir may provide a benefit. In this open-label trial in sub-Saharan Africa, we randomly assig...

Effect of a single inactivated poliovirus vaccine dose on intestinal immunity against p...
https://doi.org/10.1016/S0140-6736(14)60934-X
Lancet (London, England); John J, Giri S et. al.

Jul 15th, 2014 - Intestinal immunity induced by oral poliovirus vaccine (OPV) is imperfect and wanes with time, permitting transmission of infection by immunised children. Inactivated poliovirus vaccine (IPV) does not induce an intestinal mucosal immune response, but could boost protection in children who are mucosally primed through previous exposure to OPV. We aimed to assess the effect of IPV on intestinal i...

Omalizumab therapy for bullous pemphigoid.
https://doi.org/10.1016/j.jaad.2014.04.053
Journal of the American Academy of Dermatology; Yu KK, Crew AB et. al.

Jun 23rd, 2014 - Bullous pemphigoid (BP) responds to a variety of immunosuppressive agents and usually controls, but does not cure, the disease. Omalizumab, Food and Drug Administration-approved for asthma, selectively suppresses the activity of IgE, an important immunoglobulin in the pathogenesis of BP. We wished to determine if systemic omalizumab would have a therapeutic effect in patients with BP. We treate...

Clinical picture and treatment of 2212 patients with common variable immunodeficiency.
https://doi.org/10.1016/j.jaci.2013.12.1077
The Journal of Allergy and Clinical Immunology; Gathmann B, Mahlaoui N et. al.

Mar 3rd, 2014 - Common variable immunodeficiency (CVID) is an antibody deficiency with an equal sex distribution and a high variability in clinical presentation. The main features include respiratory tract infections and their associated complications, enteropathy, autoimmunity, and lymphoproliferative disorders. This study analyzes the clinical presentation, association between clinical features, and differen...

School-located influenza vaccination decreases laboratory-confirmed influenza and impro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155443
Clinical Infectious Diseases : an Official Publication Of... Pannaraj PS, Wang HL et. al.

May 15th, 2014 - School-located influenza vaccination (SLV) programs can efficiently immunize large numbers of school-aged children. We evaluated the impact of SLV on laboratory-confirmed influenza and absenteeism. Active surveillance for influenza-like illness (ILI) was conducted on 4455 children in 4 SLV intervention and 4 control elementary schools (grades K-6) matched for sociodemographic characteristics du...

Invasive pneumococcal disease after implementation of 13-valent conjugate vaccine.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187237
Pediatrics Iroh Tam PY, Madoff LC et. al.

Jul 8th, 2014 - To examine whether there is a different clinical profile and severity of invasive pneumococcal disease (IPD) in children caused by nonvaccine types in the era of 13-valent pneumococcal conjugate vaccine (PCV13). Observational study of childhood IPD in Massachusetts based on state public health surveillance data comparing pre-PCV13 (2007-2009) and post-PCV13 (2010-2012) eras. There were 168 pre-...

Transplantation outcomes for severe combined immunodeficiency, 2000-2009.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183064
The New England Journal of Medicine; Pai SY, Logan BR et. al.

Jul 30th, 2014 - The Primary Immune Deficiency Treatment Consortium was formed to analyze the results of hematopoietic-cell transplantation in children with severe combined immunodeficiency (SCID) and other primary immunodeficiencies. Factors associated with a good transplantation outcome need to be identified in order to design safer and more effective curative therapy, particularly for children with SCID diag...

Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236912
Annals of Internal Medicine; Henrich TJ, Hanhauser E et. al.

Jul 22nd, 2014 - It is unknown whether the reduction in HIV-1 reservoirs seen after allogeneic hematopoietic stem cell transplantation (HSCT) with susceptible donor cells is sufficient to achieve sustained HIV-1 remission. To characterize HIV-1 reservoirs in blood and tissues and perform analytic antiretroviral treatment interruptions to determine the potential for allogeneic HSCT to lead to sustained, antiretr...

Comparative analysis of rosacea and cutaneous lupus erythematosus: histopathologic feat...
https://doi.org/10.1016/j.jaad.2014.01.892
Journal of the American Academy of Dermatology; Brown TT, Choi EY et. al.

Mar 24th, 2014 - Distinction of rosacea and cutaneous lupus erythematosus (LE) can be challenging because of significant clinical and histologic overlap. A controlled study comparing these conditions is lacking. We compared the histologic features, T-cell subsets, and plasmacytoid dendritic cells in rosacea and LE. Biopsy specimens of rosacea (n = 27) and facial LE (n = 30) were retrospectively reviewed and rea...