PloS One; Wisnewski AV, Redlich CA et. al.
Sep 10th, 2021 - Reverse vaccinology is an evolving approach for improving vaccine effectiveness and minimizing adverse responses by limiting immunizations to critical epitopes. Towards this goal, we sought to identify immunogenic amino acid motifs and linear epitopes of the SARS-CoV-2 spike protein that elicit IgG in COVID-19 mRNA vaccine recipients. Paired pre/post vaccination samples from N = 20 healthy adul...
PloS One; Kulkarni R, Chen WC et. al.
Sep 10th, 2021 - COVID-19 in humans is caused by Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that belongs to the beta family of coronaviruses. SARS-CoV-2 causes severe respiratory illness in 10-15% of infected individuals and mortality in 2-3%. Vaccines are urgently needed to prevent infection and to contain viral spread. Although several mRNA- and adenovirus-based vaccines are highly effective...
https://doi.org/10.1038/d41586-021-02423-8 10.7189/jogh.11.05013 10.1172/jci.insight.148694 10.1126/scitranslmed.abd5487 10.1038/s41467-021-24938-4 10.1038/s41467-021-21414-x 10.1038/s41587-021-01037-9 10.1126/science.abd4570 10.1126/science.abd4585 10.1126/sciimmunol.abl4340 10.1038/s41467-021-22236-7
Nature Mallapaty S
Sep 9th, 2021 - Kids and COVID: why young immune systems are still on top.|2021|Mallapaty S,|epidemiology,genetics,immunology,virology,immunology,virology,genetics,immunology,genetics,immunology,metabolism,genetics,immunology,genetics,immunology,immunology,immunology,epidemiology,virology,immunology,
Proceedings of the National Academy of Sciences of the Un... Dalvie NC, Rodriguez-Aponte SA et. al.
Sep 9th, 2021 - Global containment of COVID-19 still requires accessible and affordable vaccines for low- and middle-income countries (LMICs). Recently approved vaccines provide needed interventions, albeit at prices that may limit their global access. Subunit vaccines based on recombinant proteins are suited for large-volume microbial manufacturing to yield billions of doses annually, minimizing their manufac...
Chest Gable AD, Hughes SM et. al.
Sep 8th, 2021 - A 24-year-old man, never smoker, with no medical or surgical history, not currently on medications, presented to the ED with a second episode of gross hemoptysis, 4 months after an initial episode that had not previously been evaluated. He described the current episode of hemoptysis as "enough to fill the sink"; however, he did not further quantify. He has no history of recurrent epistaxis, hem...
Virology Journal; Pessoa NL, Bentes AA et. al.
Sep 7th, 2021 - Covid-19 has the respiratory tract as the main target of infection, and patients present mainly dyspnea, pneumonia, dry cough, and fever. Nevertheless, organs outside the respiratory tract had been reported in recent studies, including the gastrointestinal tract and liver. The host innate immune system recognizes pathogen-associated molecular patterns (PAMPs) through their pattern recognition r...
Proceedings of the National Academy of Sciences of the Un... Melvin WJ, Audu CO et. al.
Sep 5th, 2021 - COVID-19 induces a robust, extended inflammatory "cytokine storm" that contributes to an increased morbidity and mortality, particularly in patients with type 2 diabetes (T2D). Macrophages are a key innate immune cell population responsible for the cytokine storm that has been shown, in T2D, to promote excess inflammation in response to infection. Using peripheral monocytes and sera from human ...
Anticancer Research; Koike K, Nishiyama K et. al.
Sep 4th, 2021 - The role of tumour-infiltrating CD45Ro+ T-cells in oral squamous cell carcinoma (OSCC) is unclear. This study aimed to evaluate prognostic biomarkers for OSCC. We determined the density of tumour-infiltrating CD45Ro+ T cells in the parenchyma and stroma at the tumour centre (TCe) and invasive front (IF) and examined the association between the density of these cells and histopathological status...
Anticancer Research; VON Hoerschelmann E, Neumann CCM et. al.
Sep 4th, 2021 - Pancreatic ductal adenocarcinoma (PDAC) shows poor survival and early systemic dissemination. Cancer associated fibroblasts (CAFs) enhance migration and invasion of cancer cells. We aimed to investigate the role of CAFs in cell migration and their underlying paracrine effects. Using Transwell® migration assays, PDAC cells (PANC-1) and three distinct types of fibroblasts were analyzed: CAFs, gen...
Medicine Wang L, Wang H et. al.
Sep 4th, 2021 - The treatment for squamous cell lung cancer (SqCLC) is limited, and the prognosis of SqCLC is poor. In this article, we aimed to analyze and identify immune-related cells and competition endogenous RNA (ceRNA) that influence the prognosis of SqCLC. SqCLC and lung adenocarcinoma data were downloaded from TCGA-GDC. A total of 22 types of immune cell fractions were estimated using CIBERSORT. R sof...
Nature Mallapaty S
Sep 4th, 2021 - India's DNA COVID vaccine is a world first - more are coming.|2021|Mallapaty S,|immunology,prevention & control,administration & dosage,immunology,supply & distribution,administration & dosage,immunology,supply & distribution,
https://doi.org/10.1038/s41467-021-25382-0 10.1056/NEJMoa2024671 10.1038/s41586-020-2607-z 10.15585/mmwr.mm6950e2 10.1056/NEJMoa2028436 10.1016/S0140-6736(21)00234-8 10.1093/infdis/jiu648 10.1016/j.immuni.2020.11.015 10.1016/j.ebiom.2016.01.029 10.1371/journal.ppat.1009025 10.1172/JCI99005 10.3389/fimmu.2019.01134 10.1073/pnas.2003138117 10.1097/QAD.0b013e3283624305 10.4049/jimmunol.1102390 10.1586/14760584.2015.965690 10.1038/s41564-020-00813-8 10.1126/science.abc4776
Nature Communications; Marlin R, Godot V et. al.
Sep 3rd, 2021 - Achieving sufficient worldwide vaccination coverage against SARS-CoV-2 will require additional approaches to currently approved viral vector and mRNA vaccines. Subunit vaccines may have distinct advantages when immunizing vulnerable individuals, children and pregnant women. Here, we present a new generation of subunit vaccines targeting viral antigens to CD40-expressing antigen-presenting cells...
Proceedings of the National Academy of Sciences of the Un... King HAD, Joyce MG et. al.
Sep 3rd, 2021 - Emergence of novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need for next-generation vaccines able to elicit broad and durable immunity. Here we report the evaluation of a ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein (RFN) adjuvanted with Army Liposomal Formulation QS-21 (ALFQ). RFN vacci...
The New England Journal of Medicine; Wilder-Smith A, Mulholland K
Sep 2nd, 2021 - Effectiveness of an Inactivated SARS-CoV-2 Vaccine.|2021|Wilder-Smith A,Mulholland K,|epidemiology,prevention & control,immunology,epidemiology,prevention & control,statistics & numerical data,
Clinical Chemistry; Zhang YV, Wiencek J et. al.
Sep 2nd, 2021 - The clinical laboratory continues to play a critical role in managing the coronavirus pandemic. Numerous US Food and Drug Administration emergency use authorization (EUA) and laboratory-developed test (LDT) serologic assays have become available. The performance characteristics of these assays and their clinical utility continue to be defined in real time during this pandemic. The AACC convened...
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Nature Communications; Das K, Belnoue E et. al.
Sep 2nd, 2021 - Functional tumor-specific cytotoxic T cells elicited by therapeutic cancer vaccination in combination with oncolytic viruses offer opportunities to address resistance to checkpoint blockade therapy. Two cancer vaccines, the self-adjuvanting protein vaccine KISIMA, and the recombinant oncolytic vesicular stomatitis virus pseudotyped with LCMV-GP expressing tumor-associated antigens, termed VSV-G...
The Journal of Infectious Diseases; Kim MH, Salloum S et. al.
Sep 2nd, 2021 - We analyzed plasma levels of interferons (IFNs) and cytokines, and expression of IFN-stimulated genes in peripheral blood mononuclear cells in patients with coronavirus disease 2019 of varying disease severity. Patients hospitalized with mild disease exhibited transient type I IFN responses, while intensive care unit patients had prolonged type I IFN responses. Type II IFN responses were compro...
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Nature Communications; Zhou X, Cao SM et. al.
Sep 2nd, 2021 - Using Epstein-Barr virus (EBV)-based markers to screen populations at high risk for nasopharyngeal carcinoma (NPC) is an attractive preventive approach. Here, we develop a comprehensive risk score (CRS) that combines risk effects of EBV and human genetics for NPC risk stratification and validate this CRS within an independent, population-based dataset. Comparing the top decile with the bottom q...
The Journal of Infectious Diseases; Noh JY, Kwak JE et. al.
Sep 2nd, 2021 - There is insufficient data on the longevity of immunity acquired after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to evaluate the duration of SARS-CoV-2-specific humoral and cellular immunity according to the clinical severity of coronavirus disease 2019 (COVID-19). The study population comprised asymptomatic (n = 14), symptomatic/nonpneumonic (n = 42), and...
Critical Care (London, England); Williams T, McGrath BA
Sep 1st, 2021 - This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2021. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2021 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from https://link.springer.com/bookseries/8901 .