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About 370,283 results

Pentacenones as Divergent Intermediates to Unsymmetrically Substituted Pentacenes: Synt...
https://doi.org/10.1021/acs.joc.2c01755
The Journal of Organic Chemistry; Schroeder ZW, McDonald R et. al.

Nov 24th, 2022 - We report a general method for the desymmetrization of 6,13-pentacenequinone to access ethynylated pentacene ketones, namely, 13-hydroxy-13-(ethynylated)pentacene-6(13H)-ones. These pentacene ketones ("pentacenones") serve as divergent intermediates to unsymmetrically 6,13-disubstituted pentacenes, commonly used for studying singlet fission processes and charge transport phenomena in organic fi...

Timing of kidney replacement therapy initiation for acute kidney injury.
https://doi.org/10.1002/14651858.CD010612.pub3
The Cochrane Database of Systematic Reviews; Fayad AI, Buamscha DG et. al.

Nov 24th, 2022 - Acute kidney injury (AKI) is a common condition among patients in intensive care units (ICUs) and is associated with high numbers of deaths. Kidney replacement therapy (KRT) is a blood purification technique used to treat the most severe forms of AKI. The optimal time to initiate KRT so as to improve clinical outcomes remains uncertain. This is an update of a review first published in 2018. Thi...

Synthetic nanobodies as tools to distinguish IgG Fc glycoforms.
https://doi.org/10.1073/pnas.2212658119
Proceedings of the National Academy of Sciences of the Un... Kao KS, Gupta A et. al.

Nov 22nd, 2022 - Protein glycosylation is a crucial mediator of biological functions and is tightly regulated in health and disease. However, interrogating complex protein glycoforms is challenging, as current lectin tools are limited by cross-reactivity while mass spectrometry typically requires biochemical purification and isolation of the target protein. Here, we describe a method to identify and characteriz...

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by M...
https://doi.org/10.3791/64522
Journal of Visualized Experiments : JoVE; Almaraz-Arreortua A, Sosa-Luis SA et. al.

Nov 22nd, 2022 - Neutrophils function as the first line of cellular defense in an innate immune response by employing diverse mechanisms, such as the formation of neutrophil extracellular traps (NETs). This study analyzes the morphological and compositional changes in NETs induced by microbial and chemical stimuli using standardized in vitro methodologies for NET induction and characterization with human cells....

In vitro effects of combustion generated carbon dots on cellular parameters in healthy ...
https://doi.org/10.1080/17435390.2022.2144775
Nanotoxicology Dinger N, Panzetta V et. al.

Nov 21st, 2022 - Carbon nanomaterials are an inventive class of materials with wide applications in state-of-the-art bioimaging and therapeutics. They allow a broad range of tunable and integrated advantages of structural flexibility, chemical and thermal stability, upright electrical conductivity, and the option of scale-up and mass production. In the context of nanomedicine, carbon nanomaterials have been use...

Hemoadsorption as part of a multimodal therapy concept to treat Capnocytophaga sepsis w...
https://doi.org/10.1177/03913988221132575
The International Journal of Artificial Organs; Kreutz J, Choukeir M et. al.

Nov 20th, 2022 - Capnocytophaga, a bacteria native to the oral flora of canines, in rare cases can lead to severe infections resulting in septic shock, respiratory tract infection, and multiple organ failure. In case of trauma following animal bites with rapidly progressing clinical courses, also adjunctive therapeutic measures such as extracorporeal blood purification therapies might be beneficial. We report o...

Evaluation of pyrite/sodium hypochlorite for activating purification of arsenic from fr...
https://doi.org/10.1016/j.envpol.2022.120681
Environmental Pollution (Barking, Essex : 1987); Lee DW, Ahn Y et. al.

Nov 19th, 2022 - In this work, the effectiveness of pyrite/sodium hypochlorite (FeS2/NaClO) treatment to eliminate arsenic (As) from fractured-bedrock groundwater via oxidative adsorption was evaluated. The As concentration in the tested reactors decreased sharply during the initial 5 min, as the addition of NaClO effectively increased the As removal efficiency, attaining 98.6% removal within 60 min in the pres...

KRGG1 function in RNA editing in Trypanosoma brucei.
https://doi.org/10.1261/rna.079418.122
RNA (New York, N.Y.); Carnes J, Gendrin C et. al.

Nov 19th, 2022 - Mitochondrial gene expression in trypanosomes requires numerous multiprotein complexes that are unique to kinetoplastids. Among these, the most well characterized are RNA Editing Catalytic Complexes (RECCs) that catalyze the guide RNA (gRNA)-specified insertion and deletion of uridines during mitochondrial mRNA maturation. This post-transcriptional resequencing of mitochondrial mRNAs can be ext...

Challenges and future scope of exosomes in the treatment of cardiovascular diseases.
https://doi.org/10.1113/JP282053
The Journal of Physiology; Ranjan P, Colin K et. al.

Nov 19th, 2022 - Exosomes are nano-sized vesicles that carry biologically diverse molecules for intercellular communication. Researchers have been trying to engineer exosomes for therapeutic purposes using different approaches to deliver biologically active molecules to the various target cells efficiently. Recent technological advances may modify the biodistribution and pharmacokinetics of exosomes to meet sci...

A systematic review of breast milk microbiota composition and the evidence for transfer...
https://doi.org/10.3920/BM2021.0098
Beneficial Microbes; Edwards CA, Van Loo-Bouwman CA et. al.

Nov 16th, 2022 - The intestinal microbiota plays a major role in infant health and development. However, the role of the breastmilk microbiota in infant gut colonisation remains unclear. A systematic review was performed to evaluate the composition of the breastmilk microbiota and evidence for transfer to/colonisation of the infant gut. Searches were performed using PUBMED, OVID, LILACS and PROQUEST from incept...

Advances in extraction, purification, structural characteristics and biological activit...
https://doi.org/10.1016/j.ijbiomac.2022.11.099
International Journal of Biological Macromolecules; Gao Y, Guo M et. al.

Nov 16th, 2022 - Hemicelluloses, a major component of plant cell walls, are a non-cellulosic heteropolysaccharide composed of several distinct sugars that is second in abundance to cellulose, which are one of the most abundant and cheapest renewable resources on earth. Hemicelluloses structure is complex and its chemical structure varies greatly among the different plant species. In addition to its wide use in ...

An assessment of DNA extraction methods from blood-stained soil in forensic science.
https://doi.org/10.1016/j.forsciint.2022.111502
Forensic Science International; Howarth A, Drummond B et. al.

Nov 14th, 2022 - In forensic crime scene investigations, biological fluids such as blood are commonly found in soil. However, the analysis of blood-stained soil can be challenging due to the presence of inhibitors which limit the effective extraction and amplification of the deoxyribonucleic acid (DNA) required to produce a reportable DNA profile. There are some extraction methods that have been applied to bloo...

Blood transfusion in autoimmune rheumatic diseases.
https://doi.org/10.1016/j.transci.2022.103596
Transfusion and Apheresis Science : Official Journal of T... Goubran H, Ragab G et. al.

Nov 13th, 2022 - Autoimmune rheumatic disorders (ARD) represent a wide spectrum of disorders that affect in priority the joints, bones, muscles, and connective tissues. Examples of ARD include rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, polymyositis, systemic sclerosis, antiphospholipid syndrome and mixed connective tissue disease. Patients with ARD often require transfusion of red cel...

Engineering yeast for high-level production of diterpenoid sclareol.
https://doi.org/10.1016/j.ymben.2022.11.002
Metabolic Engineering; Cao X, Yu W et. al.

Nov 13th, 2022 - The diterpenoid sclareol is an industrially important precursor for alternative sustainable supply of ambergris. However, its current production from plant extraction is neither economical nor environmental-friendly, since it requires laborious and cost-intensive purification procedures and plants cultivation is susceptible to environmental factors. Engineering cell factories for bio-manufactur...

Immobilization of Biomass Materials for Removal of Refractory Organic Pollutants from W...
https://doi.org/10.3390/ijerph192113830
International Journal of Environmental Research and Publi... Liu D, Yang X et. al.

Nov 12th, 2022 - In the field of environmental science and engineering, microorganisms, enzymes and algae are promising biomass materials that can effectively degrade pollutants. However, problems such as poor environmental adaptability, recycling difficulties, and secondary pollution exist in the practical application of non-immobilized biomass materials. Biomass immobilization is a novel environmental remedia...

An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts.
https://doi.org/10.1038/s41587-022-01525-6
Nature Biotechnology; Dousis A, Ravichandran K et. al.

Nov 12th, 2022 - In vitro transcription (IVT) is a DNA-templated process for synthesizing long RNA transcripts, including messenger RNA (mRNA). For many research and commercial applications, IVT of mRNA is typically performed using bacteriophage T7 RNA polymerase (T7 RNAP) owing to its ability to produce full-length RNA transcripts with high fidelity; however, T7 RNAP can also produce immunostimulatory byproduc...

Stratum Ventilation: Enabling Simultaneous Energy Conservation and Air Purification in ...
https://doi.org/10.3390/ijerph192114521
International Journal of Environmental Research and Publi... Mao Y, Wang S et. al.

Nov 12th, 2022 - The supply of fresh air for underground rail transit systems is not as simple as opening windows, which is a conventional ventilation (CV) measure adopted in aboveground vehicles. This study aims to improve contaminant dilution and air purification in subway car ventilation systems and the safety of rail transit post-coronavirus disease pandemic era. We designed an air conditioning (AC) termina...

Transformation Path of Ecological Product Value and Efficiency Evaluation: The Case of ...
https://doi.org/10.3390/ijerph192114575
International Journal of Environmental Research and Publi... Yu H, Shao C et. al.

Nov 12th, 2022 - In order to protect wetland resources, China has developed wetland conservation policies and has made significant conservation investments, but there is still a lack of pathways for the conversion to economic value, making it difficult to meet the demand for continuous investment. We have explored a sustainable ecological conservation mechanism using the Seven Mile Sea as a case study, so that ...

Fully-exposed Pt-Fe cluster for efficient preferential oxidation of CO towards hydrogen...
https://doi.org/10.1038/s41467-022-34674-y
Nature Communications; Jia Z, Qin X et. al.

Nov 11th, 2022 - Hydrogen is increasingly being discussed as clean energy for the goal of net-zero carbon emissions, applied in the proton-exchange-membrane fuel cells (PEMFC). The preferential oxidation of CO (PROX) in hydrogen is a promising solution for hydrogen purification to avoid catalysts from being poisoned by the trace amount of CO in hydrogen-rich fuel gas. Here, we report the fabrication of a novel ...

Purification, physico-chemical properties and antioxidant activity of polysaccharides f...
https://doi.org/10.1016/j.ijbiomac.2022.11.030
International Journal of Biological Macromolecules; Wan C, Jiang H et. al.

Nov 11th, 2022 - The biological activities of Sargassum fusiforme polysaccharides (SFP) were affected significantly by the extraction method. In order to screen the optimum extraction technology for SFP with high yield and biological activities, six extraction methods, including hot water extraction (HWE), acid-assisted extraction (ACAE), alkali-assisted extraction (ALAE), ultrasonic-assisted extraction (UAE), ...