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About 369,095 results

Microalgae-derived polysaccharides: Potential building blocks for biomedical applications.
https://doi.org/10.1007/s11274-022-03342-0 10.2174/138955708784912148 10.1002/adfm.202010732 10.1016/j.algal.2020.102107 10.1016/j.carbpol.2013.02.016 10.1016/j.ijbiomac.2019.05.104 10.1021/acs.biomac.0c01406 10.3390/md16090298 10.1016/j.carbpol.2018.05.001 10.3390/md18010007 10.1016/j.ijbiomac.2013.03.046 10.1007/s11274-019-2745-3 10.1016/j.jbiotec.2021.12.008 10.1016/j.ijbiomac.2016.05.086 10.3390/molecules24020322 10.1080/07388551.2021.1941750 10.3390/polysaccharides2040046 10.1016/j.carbpol.2010.05.029 10.1159/000495922 10.1016/j.biotechadv.2016.08.001 10.1016/j.lwt.2020.110780 10.3389/fpls.2012.00082 10.1016/j.micres.2020.126653 10.1017/S000711450000177X 10.3390/nu1020156 10.1007/s11274-012-1248-2 10.1016/j.foodres.2021.110596 10.3389/fmicb.2017.02541 10.1080/13102818.2009.10818540 10.1023/A:1008102622276 10.1002/bit.21573 10.1016/j.biortech.2012.11.077 10.1002/ptr.1227 10.1111/1541-4337.12136 10.1021/np960017o 10.1016/S0166-3542(02)00132-8 10.1016/j.actbio.2013.12.055 10.1021/jf902952z 10.1002/jssc.201200874 10.1016/S0165-022X(01)00186-5 10.1016/j.cofs.2018.12.003 10.1016/j.ijbiomac.2012.11.023 10.3390/md15040100 10.1016/j.foodhyd.2021.107049 10.1007/s00449-018-1987-z 10.1016/j.fbp.2018.02.002 10.18520/cs/v115/i2/234-241 10.1016/j.ijbiomac.2015.01.005 10.1016/j.algal.2020.101909 10.3390/md20050336 10.1016/j.procbio.2021.08.018 10.1016/j.indcrop.2022.114675 10.3390/md15120376 10.1016/j.bbagen.2009.07.013 10.1016/j.ijbiomac.2014.02.053 10.1016/j.algal.2014.03.006 10.1385/ABAB:104:1:13 10.1016/j.biortech.2009.02.006 10.1007/s10924-021-02052-2 10.1007/978-3-030-35734-4_49-1 10.1007/978-3-030-42215-8_20 10.3390/cosmetics4040046 10.1007/s10811-020-02280-4 10.1007/s10924-021-02231-1 10.1016/j.micres.2021.126813 10.1016/j.biortech.2012.12.038 10.3390/molecules24234296 10.1016/j.ijbiomac.2016.11.039 10.1016/j.jtice.2015.02.004 10.4172/jaa.1000023 10.1016/j.lfs.2014.09.018 10.3390/md11010233 10.3390/md13052967 10.3390/md14020027 10.1016/j.carbpol.2016.01.075 10.1016/j.scitotenv.2021.151111 10.1016/j.carbpol.2014.04.077 10.1007/s10811-011-9692-1 10.1016/j.ijbiomac.2019.11.178 10.1016/j.rser.2019.06.020 10.1016/j.carbpol.2018.06.111 10.1016/j.biortech.2021.126304 10.1021/bm060365x 10.1186/s12906-016-1198-6 10.1002/star.201400127 10.1021/acs.jafc.9b06282 10.1016/j.carbpol.2013.02.076 10.1016/j.ijbiomac.2017.09.018 10.3389/fnut.2021.747928 10.1016/j.fitote.2011.10.016 10.1016/j.ijbiomac.2014.03.036 10.1016/j.carbpol.2008.12.015 10.1007/s00217-006-0315-z 10.7717/peerj.6409 10.1007/s10126-003-0002-z 10.1007/s10126-004-0404-6 10.1016/j.carbpol.2014.06.058 10.1016/j.ijbiomac.2020.09.080 10.1039/c1an15605e 10.1016/j.ijbiomac.2019.02.009 10.1016/j.ijbiomac.2019.05.117 10.1016/j.tifs.2017.12.001 10.1016/j.renene.2017.11.046 10.1002/VIW.20200189 10.1016/j.foodchem.2022.132236 10.1016/j.biortech.2019.121588
World Journal of Microbiology & Biotechnology; Severo IA, Dias RR et. al.

Jul 2nd, 2022 - In recent years, the increasing concern about human health well-being has strongly boosted the search for natural alternatives that can be used in different fields, especially in biomedicine. This has put microalgae-based products in evidence since they contain many bioactive compounds, of which polysaccharides are attractive due to the diverse physicochemical properties and new or improved bio...

Rapid detection of methicillin-resistant Staphylococcus aureus in positive blood-cultur...
https://doi.org/10.1371/journal.pone.0270686
PloS One; Srisrattakarn A, Panpru P et. al.

Jul 1st, 2022 - Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), is an important bacterium that causes community and healthcare-related infections throughout the world. However, the current conventional detection methods are time-consuming. We therefore developed and evaluated a recombinase polymerase amplification-lateral flow strip (RPA-LF) approach for detection of MRSA in positive ...

Characterization of some fungal pathogens causing anthracnose disease on yam in Cross R...
https://doi.org/10.1371/journal.pone.0270601
PloS One; Okon NI, Markson AA et. al.

Jun 30th, 2022 - Yam anthracnose is one of the most serious fungal diseases affecting white and water yam production. Screening of available landraces for new sources of durable resistance to the pathogen is a continuous process. In the present study, the pathogens causing anthracnose in Dioscorea alata and Dioscorea rotundata farms in Cross River State yam belt region were characterized. Diseased yam leaves wi...

SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoa...
https://doi.org/10.1038/s41467-022-31193-8 10.1016/j.cell.2014.02.039 10.1002/biot.201100155 10.1073/pnas.1704872114 10.1016/j.cell.2016.09.013 10.1021/acssynbio.8b00448 10.1073/pnas.2009707117 10.1073/pnas.1401291111 10.1038/srep19234 10.1039/D0SC01878C 10.1038/s41467-019-09678-w 10.1073/pnas.1909653116 10.1038/ncomms3211 10.1021/acsmacrolett.8b00668 10.1039/C7CC04507G 10.1021/jacs.1c03198 10.1038/372379a0 10.1038/nbt725 10.4161/19420862.2014.985993 10.1126/science.aav7897 10.1093/database/baz024 10.1126/science.abf6840 10.1038/s41564-020-0771-4 10.1016/j.cell.2021.09.015 10.1002/0471140864.ps0601s80 10.1002/anie.201707623 10.1016/j.chom.2020.11.004 10.1016/j.coi.2020.03.013 10.3389/fimmu.2018.01432 10.1002/anie.202009663 10.1126/science.abb9983 10.1016/j.vaccine.2016.10.079 10.1016/j.memsci.2007.02.045 10.1038/s41586-020-2852-1 10.1371/journal.ppat.1009352 10.1126/science.abb7269 10.1038/s41594-020-0480-y 10.1016/j.cell.2018.12.028 10.1038/s41467-020-20654-7 10.1093/protein/10.8.975 10.3109/07853890.2011.579150 10.1073/pnas.0402222101 10.1016/j.chroma.2013.07.015 10.1016/j.chroma.2014.08.046 10.18388/abp.1999_4131 10.1016/j.pep.2004.10.017 10.1016/j.ijpara.2016.12.001 10.1016/j.chembiol.2021.07.005 10.1038/s42003-019-0457-8 10.1007/s00449-020-02382-w 10.1038/s41467-020-20251-8 10.3390/vaccines9060651 10.1016/j.celrep.2021.109760 10.1038/s41586-021-03807-6 10.1007/s10969-010-9090-y 10.1073/pnas.1115485109 10.1158/0008-5472.CAN-12-2956 10.1038/s42003-021-02487-2 10.7150/thno.65563 10.1038/nprot.2009.3 10.1073/pnas.1510199112 10.1016/j.jmb.2013.10.021 10.1002/prot.22927 10.1007/s10930-019-09838-3 10.1021/acsnano.8b02805 10.1038/s41586-020-2180-5 10.1093/molbev/msab120 10.1093/nar/gkz268
Nature Communications; Vester SK, Rahikainen R et. al.

Jun 29th, 2022 - Proteins can be empowered via SpyTag for anchoring and nanoassembly, through covalent bonding to SpyCatcher partners. Here we generate a switchable version of SpyCatcher, allowing gentle purification of SpyTagged proteins. We introduce numerous histidines adjacent to SpyTag's binding site, giving moderate pH-dependent release. After phage-based selection, our final SpySwitch allows purification...

Purification, identification, and antioxidative mechanism of three novel selenium-enric...
https://doi.org/10.1016/j.foodres.2022.111359
Food Research International (Ottawa, Ont.); Xia Z, Miao J et. al.

Jun 29th, 2022 - Natural organic selenium (Se) has multiple physiological health benefits and has become a hotspot of research in recent years. In this study, the Se-enriched antioxidant peptides were purified from Se-enriched oyster hydrolysate. Three novel Se-enriched antioxidant peptides LLVSeMY (685.2953 Da), MMDSeML (687.1875 Da) and VSeMDSeML (703.1599 Da) were identified from fraction F6-4, which all exh...

Isolation, structure and bioactivity of polysaccharides from Atractylodes macrocephala:...
https://doi.org/10.1016/j.jep.2022.115506
Journal of Ethnopharmacology; Li X, Rao Z et. al.

Jun 28th, 2022 - Polysaccharides from Atractylodes macrocephala are important components isolated and extracted from the traditional Chinese medicine named Atractylodes macrocephala Koidz. Traditionally, A. macrocephala has been used to strengthen the spleen, benefit qi, dry dampness and promote water circulation, and prevent miscarriage. As the main components, polysaccharides from A. macrocephala have a varie...

FACS-isolation and Culture of Fibro-Adipogenic Progenitors and Muscle Stem Cells from U...
https://doi.org/10.3791/63983
Journal of Visualized Experiments : JoVE; Riparini G, Simone JM et. al.

Jun 28th, 2022 - Fibro-adipogenic progenitor cells (FAPs) are a population of skeletal muscle-resident mesenchymal stromal cells (MSCs) capable of differentiating along fibrogenic, adipogenic, osteogenic, or chondrogenic lineage. Together with muscle stem cells (MuSCs), FAPs play a critical role in muscle homeostasis, repair, and regeneration, while actively maintaining and remodeling the extracellular matrix (...

Reconstitution of the functional carotenoid-binding protein from silkworm in E. coli.
https://doi.org/10.1016/j.ijbiomac.2022.06.135
International Journal of Biological Macromolecules; Slonimskiy YB, Egorkin NA et. al.

Jun 27th, 2022 - Natural water-soluble carotenoproteins are promising antioxidant nanocarriers for biomedical applications. The Carotenoid-Binding Protein from silkworm Bombyx mori (BmCBP) is responsible for depositing carotenoids in cocoons. This determines the silk coloration, which is relevant for sericulture for four thousand years. While BmCBP function is well-characterized by molecular genetics, its struc...

Myoglobin from Atlantic and Tinker mackerels: Purification, characterization and its po...
https://doi.org/10.1016/j.ijbiomac.2022.06.128
International Journal of Biological Macromolecules; Ragucci S, Woodrow P et. al.

Jun 27th, 2022 - Here, we report the characterization (purification, autoxidation rate, pseudoperoxidase activity) and amino acid sequence determination of S. scombrus (Atlantic mackerel) and S. colias (Tinker mackerel) mioglobins (Mbs), considering the increasing consumption of fresh and canned mackerel meat and Mb implication in meat storage (e.g.: browning and lipid oxidation). We found that Atlantic mackere...

Production of a murine mAb against Bothrops alternatus and B. neuwiedi snake venoms and...
https://doi.org/10.1016/j.ijbiomac.2022.06.127
International Journal of Biological Macromolecules; Belo AA, Naves de Souza DL et. al.

Jun 27th, 2022 - Accidents with snakes from the genus Bothrops represent ~90 % of all snakebites in Brazil. Monoclonal antibodies (mAbs) targeting venom components can be important assets for treating envenoming syndromes, for developing diagnostic tests and for research purposes. Therefore, in this study, we aimed to generate murine mAbs against the antigenic mixture of Bothropic venoms traditionally used as i...

Suitable coverage and slope guided by soil and water conservation can prevent non-point...
https://doi.org/10.1016/j.ecoenv.2022.113804
Ecotoxicology and Environmental Safety; Hou G, Zheng J et. al.

Jun 27th, 2022 - Non-point source pollution caused by surface runoff has been a popular hydrological and environmental safety issue and has attracted extensive attention from global scholars. To identify the optimal vegetation coverage of Festuca arundinacea grassland for controlling soil erosion and purifying surface runoff, bare land was chosen as the control in this experiment. Simulated rainfall experiments...

Occurrence, Distribution, and Risk Assessment of Antibiotics in the Aquatic Environment...
https://doi.org/10.3390/ijerph19127211
International Journal of Environmental Research and Publi... Guo F, Wang Y et. al.

Jun 25th, 2022 - In this study, the occurrence, distribution, and ecological risk of 40 commonly used antibiotics, including 15 sulfonamides (SAs), 9 fluoroquinolones (FQs), 7 macrolides (MCs), 3 tetracyclines (TCs), 2 chloramphenicols (CAPs), and 4 other categories, in the aquatic environment of the karst plateau wetland Caohai of the Yangtze River basin in southwestern China are reported. In total, 27 antibio...

The effects of weathering-induced degradation of polymers in the microplastic study inv...
https://doi.org/10.1016/j.envpol.2022.119669
Environmental Pollution (Barking, Essex : 1987); Lessa Belone MC, Kokko M et. al.

Jun 25th, 2022 - The analysis of microplastics in complex environmental samples requires the use of chemicals to reduce the organic matrix. This procedure should be evaluated in terms of the preservation of the microplastic's integrity, typically done with pristine reference microplastics. However, real microplastics are most likely degraded due to weathering, so pristine reference microplastics might not depic...

Structural elucidation of two novel degradants of lurasidone and their formation mechan...
https://doi.org/10.1002/jms.4871
Journal of Mass Spectrometry : JMS; Wang KC, Guo Q et. al.

Jun 24th, 2022 - Lurasidone is an antipsychotic drug clinically used for the treatment of schizophrenia and bipolar disorder. During a mechanism-based forced degradation study of lurasidone, two novel degradation products were observed under free radical-mediated oxidative (via AIBN) and solution photolytic conditions. The structures of the two novel degradants were identified through an approach combining HPLC...

Single-cell transcriptome and accessible chromatin dynamics during endocrine pancreas d...
https://doi.org/10.1073/pnas.2201267119
Proceedings of the National Academy of Sciences of the Un... Duvall E, Benitez CM et. al.

Jun 24th, 2022 - Delineating gene regulatory networks that orchestrate cell-type specification is a continuing challenge for developmental biologists. Single-cell analyses offer opportunities to address these challenges and accelerate discovery of rare cell lineage relationships and mechanisms underlying hierarchical lineage decisions. Here, we describe the molecular analysis of mouse pancreatic endocrine cell ...

Extracorporeal Blood Purification in Burns: For Whom, Why, and How?
https://doi.org/10.1159/000525085
Blood Purification; Abraham P, Monard C et. al.

Jun 24th, 2022 - Patients with serious thermal burn injuries require immediate and specialized care in order to minimize morbidity and mortality. Optimal fluid resuscitation, nutritional support, pulmonary care, burn wound care, and infection control practices represent key aspects of patient care in burn centers. When severely burned, the patient usually presents a systemic inflammatory response syndrome, soon...

Expression, Purification, and Characterisation of South African Cassava Mosaic Virus Ce...
https://doi.org/10.3390/cimb44060186
Current Issues in Molecular Biology; Nankoo N, Achilonu IA et. al.

Jun 24th, 2022 - South African cassava mosaic virus (SACMV) is a circular ssDNA bipartite begomovirus, whose genome comprises DNA-A (encodes six genes) and DNA-B (encodes BC1 cell-to-cell movement and BV1 nuclear shuttle proteins) components. A few secondary and tertiary structural and physicochemical characteristics of partial but not full-length begomovirus proteins have been elucidated to date. The full-leng...

Schools under mandatory testing can mitigate the spread of SARS-CoV-2.
https://doi.org/10.1073/pnas.2201724119
Proceedings of the National Academy of Sciences of the Un... Diederichs M, van Ewijk R et. al.

Jun 24th, 2022 - We use event study models based on staggered summer vacations in Germany to estimate the effect of school reopenings after the summer of 2021 on the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Estimations are based on daily counts of confirmed coronavirus infections across all 401 German counties. A central antipandemic measure in German schools included mandatory ra...

Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for...
https://doi.org/10.1073/pnas.2122805119
Proceedings of the National Academy of Sciences of the Un... Xu YR, Shi ML et. al.

Jun 24th, 2022 - During viral infection, sensing of viral RNA by retinoic acid-inducible gene-I-like receptors (RLRs) initiates an antiviral innate immune response, which is mediated by the mitochondrial adaptor protein VISA (virus-induced signal adaptor; also known as mitochondrial antiviral signaling protein [MAVS]). VISA is regulated by various posttranslational modifications (PTMs), such as polyubiquitinati...

Effect-directed analysis for revealing aryl hydrocarbon receptor agonists in sediment s...
https://doi.org/10.1016/j.envpol.2022.119659
Environmental Pollution (Barking, Essex : 1987); Ma Q, Liu Y et. al.

Jun 24th, 2022 - Exposure to electronic and electrical waste (e-waste) has been related to a few adverse health effects. In this study, sediment samples from an e-waste recycling town in China were collected, and aryl hydrocarbon receptor (AhR) agonists in the samples were identified using an effect-directed analysis (EDA) strategy. The CBG2.8D cell line reporter gene bioassay was used as a toxicity test, while...