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About 356,323 results

A membrane protein display platform for receptor interactome discovery.
https://doi.org/10.1073/pnas.2025451118
Proceedings of the National Academy of Sciences of the Un... Cao S, Peterson SM et. al.

Sep 18th, 2021 - Cell surface receptors are critical for cell signaling and constitute a quarter of all human genes. Despite their importance and abundance, receptor interaction networks remain understudied because of difficulties associated with maintaining membrane proteins in their native conformation and their typically weak interactions. To overcome these challenges, we developed an extracellular vesicle-b...

Copper-catalysed exclusive CO2 to pure formic acid conversion via single-atom alloying.
https://doi.org/10.1038/s41565-021-00974-5 10.1038/s41586-019-1760-8 10.1038/s41560-020-0607-8 10.1038/s41929-019-0383-7 10.1038/s41929-018-0139-9 10.1039/C8EE00097B 10.1016/j.chempr.2018.08.019 10.1002/celc.201300206 10.1016/j.joule.2017.09.014 10.1038/s41929-018-0200-8 10.1038/s41467-020-14914-9 10.1038/s41467-020-16784-7 10.1021/jacs.0c05913 10.1126/science.aay4217 10.1038/nature13249 10.1002/adma.201803111 10.1038/s41560-020-0594-9 10.1038/s41560-020-0666-x 10.1073/pnas.1711493114 10.1021/jacs.0c00122 10.1021/acscatal.0c02237 10.1038/s41560-019-0450-y 10.1021/acscatal.7b00687 10.1039/c0ee00071j 10.1021/acs.jpclett.5b00722 10.1038/s41557-018-0125-5 10.1038/s41467-019-13685-2 10.1002/smll.201906830 10.1038/s41560-019-0451-x 10.1126/science.aay1844 10.1038/s41467-020-17403-1 10.1021/acscatal.0c02130 10.1021/jacs.5b06568 10.1038/s41467-020-20004-7 10.1021/acs.jpclett.5b01559 10.1016/j.elecom.2017.07.006 10.1016/j.scib.2020.01.020 10.1002/adma.202005113 10.1021/acs.jpclett.6b00382 10.1021/acs.jpclett.5b01043 10.1021/acs.jpcc.0c06691 10.1021/acs.jpclett.8b03448 10.1016/j.jcat.2019.09.012 10.1021/acscatal.6b02405
Nature Nanotechnology; Zheng T, Liu C et. al.

Sep 18th, 2021 - Converting CO2 emissions, powered by renewable electricity, to produce fuels and chemicals provides an elegant route towards a carbon-neutral energy cycle. Progress in the understanding and synthesis of Cu catalysts has spurred the explosive development of electrochemical CO2 reduction (CO2RR) technology to produce hydrocarbons and oxygenates; however, Cu, as the predominant catalyst, often exh...

Structural analysis of the GPI glycan.
https://doi.org/10.1371/journal.pone.0257435
PloS One; Nakano M, Sabido-Bozo S et. al.

Sep 17th, 2021 - Glycosylphosphatidylinositol (GPI) anchoring of proteins is an essential post-translational modification in all eukaryotes that occurs at the endoplasmic reticulum (ER) and serves to deliver GPI-anchored proteins (GPI-APs) to the cell surface where they play a wide variety of vital physiological roles. This paper describes a specialized method for purification and structural analysis of the GPI...

Patients with Severe Lactic Acidosis in the Intensive Care Unit: A Retrospective Study ...
https://doi.org/10.1159/000518918
Blood Purification; Van De Ginste L, Vanommeslaeghe F et. al.

Sep 16th, 2021 - Hyperlactatemia is a regular condition in the intensive care unit, which is often associated with adverse outcomes. Control of the triggering condition is the most effective treatment of hyperlactatemia, but since this is mostly not readily possible, extracorporeal renal replacement therapy (RRT) is often tried as a last resort. The present study aims to evaluate the factors that may contribute...

Improved Prognostic Prediction by Combination of Early Initiation of Polymyxin B Hemope...
https://doi.org/10.1159/000518705
Blood Purification; Oishi K, Azuma A et. al.

Sep 15th, 2021 - Respiratory failure from acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is associated with high mortality. Direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP) has been reported to have beneficial effects on patients with AE-IPF. Whether patient characteristics influence the extent of this benefit remains unclear. We retrospectively examined the records of 30 p...

Platelet Decreases following Continuous Renal Replacement Therapy Initiation as a Novel...
https://doi.org/10.1159/000517232
Blood Purification; Griffin BR, Ten Eyck P et. al.

Sep 15th, 2021 - Continuous renal replacement therapy (CRRT) is a form of dialysis used in critically ill patients, and has recently been associated with renal nonrecovery. Decreases in platelets following CRRT initiation are common and are associated with mortality, but associations with renal recovery are unclear. Our objective was to determine if platelet nadir or the degree of platelet decrease following CR...

Comprehensive analysis of lysine crotonylation modification in patients with chronic re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439085
BMC Nephrology; Huang J, Tang D et. al.

Sep 15th, 2021 - Post-translational modifications (PTMs) are at the heart of many cellular signaling events, which changes the function of protein. Crotonylation, one of the most important and common PTMs, plays a crucial role in the regulation of various biological processes. However, no study has evaluated the role of lysine crotonylation modification in chronic renal failure (CRF) patients. Here, we comparat...

Improved Dialysis Removal of Protein-Bound Uraemic Toxins with a Combined Displacement ...
https://doi.org/10.1159/000518065
Blood Purification; Shi Y, Tian H et. al.

Sep 14th, 2021 - Protein-bound uraemic toxins (PBUTs) are poorly removed by conventional dialytic techniques, given their high plasma protein binding, and thus low, free (dialysable) plasma concentration. Here, we evaluated and compared PBUTs removal among conventional haemodialysis (HD), adsorption-based HD, displacement-based HD, and their 2 combinations both in vitro and in vivo. The removal of PBUTs, includ...

Hyperoncotic Albumin Solution in Continuous Renal Replacement Therapy Patients.
https://doi.org/10.1159/000517957
Blood Purification; O'Brien Z, Finnis M et. al.

Sep 14th, 2021 - The aim of this study was to investigate the association of hyperoncotic (20%) human albumin solution (HAS) with outcomes among critically ill patients receiving continuous renal replacement therapy (RRT). Analysis of the Randomized Evaluation of Normal versus Augmented Level (RENAL) RRT trial data. Of 1,508 patients, 771 (51%) received albumin. Of these, 345 (45%) received 4% HAS only, 155 (20...

Endotoxemia in Critically Ill Patients with COVID-19.
https://doi.org/10.1159/000518230
Blood Purification; Khan S, Bolotova O et. al.

Sep 14th, 2021 - Mechanism(s) mediating critical illness in coronavirus disease 2019 (COVID-19) remain unclear. Previous reports demonstrate the existence of endotoxemia in viral infections without superimposed gram-negative bacteremia, but the rate and severity of endotoxemia in critically ill patients with COVID-19 requires further exploration. This is a single-center cross-sectional study of 92 intensive car...

How Dialysis Patients Cope with a Curfew? A Comparison of Psychological Status between ...
https://doi.org/10.1159/000517839
Blood Purification; Karaca C, Eren N et. al.

Sep 14th, 2021 - There are many differences between hemodialysis (HD) and peritoneal dialysis (PD) treatments, including their impact on the psychological status of the patients. In this study, our aim was to compare the psychological statuses of HD and PD patients during the social isolation period due to the COVID-19 pandemic. We conducted this cross-sectional study on adult HD and PD patients when the curfew...

Adjunct Use of Continuous Renal Replacement Therapy with Extracorporeal Membrane Oxygen...
https://doi.org/10.1159/000517896
Blood Purification; Thomas JM, Dado DN et. al.

Sep 14th, 2021 - Fluid overload in extracorporeal membrane oxygenation (ECMO) patients has been associated with increased mortality. Patients receiving ECMO and continuous renal replacement therapy (CRRT) who achieve a negative fluid balance have improved survival. Limited data exist on the use of CRRT solely for fluid management in ECMO patients. We performed a single-center retrospective review of 19 adult EC...

Tandem Therapeutic Plasma Exchange Reduces Continuous Renal Replacement Therapy Downtime.
https://doi.org/10.1159/000518348
Blood Purification; Foglia MJ, Pelletier JH et. al.

Sep 14th, 2021 - Continuous renal replacement therapy (CRRT) has become a primary treatment of severe acute kidney injury in children admitted to the intensive care unit. CRRT "downtime" (when the circuit is not active) can represent a significant portion of the prescribed treatment time and adversely affects clearance. The objective of this study was to evaluate factors associated with CRRT "downtime" and to d...

St. John's Wort (Hypericum perforatum)-Related Acute Kidney Injury.
https://doi.org/10.1159/000518349
Blood Purification; Adibelli Z, Karacay I et. al.

Sep 14th, 2021 - Some herbal products were reported to cause nephrotoxicity through different mechanisms. This case report defines an acute kidney injury (AKI) in a patient who used Hypericum perforatum tea as a sleep disorder remedy. The patient developed AKI after ingestion of tea prepared from Hypericum perforatum and underwent hemodialysis because of acute kidney failure. After 1 week, the kidney recovered,...

Functionalization of nanocellulose to quaternized nanocellulose tri-iodide and its eval...
https://doi.org/10.1016/j.ijbiomac.2021.08.228
International Journal of Biological Macromolecules; Bansal M, Dharmender et. al.

Sep 14th, 2021 - The reported research involves formation of quaternized nanocellulose triiodide for use as an agent for controlled release of iodine. Nanocellulose was extracted from bagasse and the extracted cellulose nanofibers (CNFs) were quaternized with 3-chloro-2-hydroxypropyltrimethyl ammonium chloride (CHPTAC) in NaOH/urea solution. This was followed by exchange of Cl- with I3- by reaction with KI/I2. ...

Acute Kidney Injury in Extracorporeal Membrane Oxygenation Patients: National Analysis ...
https://doi.org/10.1159/000518346
Blood Purification; Sakhuja A, McCarthy P et. al.

Sep 14th, 2021 - The aim of this study was to determine epidemiology and outcomes of acute kidney injury (AKI) in patients on extracorporeal membrane oxygenation (ECMO) and to assess if age modifies the effect of AKI on mortality. Using National (Nationwide) Inpatient Sample Database for hospitalizations in the USA from 2003 to 2014, we identified adult patients on ECMO support. Using International Classificati...

Comparative Impact of Isolated Ultrafiltration and Hemodialysis on Fluid Distribution: ...
https://doi.org/10.1159/000518228
Blood Purification; Akiyama Y, Matsuoka R et. al.

Sep 14th, 2021 - Isolated ultrafiltration (IUF) is an alternative treatment for diuretic-resistant patients with fluid retention. Although hemodialysis (HD) predominantly decreases extracellular water (ECW), the impact of IUF on fluid distribution compared with HD remains unclear. We compared the effect of HD (n = 22) and IUF (n = 10) sessions on the body fluid status using a bioimpedance analysis device (InBod...

Endotoxin and Cytokine Sequential Hemoadsorption in Septic Shock and Multi-Organ Failure.
https://doi.org/10.1159/000518229
Blood Purification; Ruiz-Rodríguez JC, Chiscano-Camón L et. al.

Sep 14th, 2021 - The mortality of septic shock remains high [Ann Intensive Care. 2017;7:19], so apart from usual therapy based on source control and antibiotics, some patients may need rescue therapies. Blood purification systems may play a role by facilitating the nonspecific removal of inflammatory mediators and microbiological toxins. There are different hemoadsorption systems, we describe in this case repor...

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malig...
https://doi.org/10.3791/62740
Journal of Visualized Experiments : JoVE; Longo JF, Brosius SN et. al.

Sep 14th, 2021 - The development of new drugs that precisely target key proteins in human cancers is fundamentally altering cancer therapeutics. However, before these drugs can be used, their target proteins must be validated as therapeutic targets in specific cancer types. This validation is often performed by knocking out the gene encoding the candidate therapeutic target in a genetically engineered mouse (GE...

Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting Y...
https://doi.org/10.1016/j.jhep.2021.08.027
Journal of Hepatology; Chen Q, Wang H et. al.

Sep 13th, 2021 - Intrahepatic cholangiocarcinoma (ICC) is a primary liver cancer with high aggressiveness and extremely poor prognosis. The role of circular RNAs (circRNAs) in ICC carcinogenesis and progression remains to be determined. CircRNA microarray was performed to screen significantly up-regulated circRNAs in paired ICC and non-tumor tissues. Colony formation, transwell, and xenograft models were used t...