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About 54,903 results

Indigenous peoples and inclusion in clinical and genomic research: Understanding the hi...
https://doi.org/10.1016/j.neo.2023.100879
Neoplasia (New York, N.Y.); Waanders A, Brown A et. al.

Feb 5th, 2023 - Despite significant improvements in pediatric cancer survival outcomes, there remain glaring disparities in under-represented racial and ethnic groups that warrant mitigation by the scientific and clinical community. To address and work towards eliminating such disparities, the Pacific Pediatric Neuro-Oncology Consortium (PNOC) and Children's Brain Tumor Network (CBTN) established a Diversity, ...

Preoperative, Intraoperative, and Postoperative Parathyroid Pathology: Clinical Patholo...
https://doi.org/10.1016/j.path.2022.10.001
Surgical Pathology Clinics; Gosnell HL, Sadow PM

Feb 5th, 2023 - Parathyroid disease typically presents with parathyroid hyperfunction as result of neoplasia or a consequence of non-neoplastic systemic disease. Given the parathyroid gland is a hormonally active organ with broad physiologic implications and serologically accessible markers for monitoring, the diagnosis of parathyroid disease is predominantly a clinical pathologic correlation. We provide the c...

Platelet transcriptome analysis in patients with germline RUNX1 mutations.
https://doi.org/10.1016/j.jtha.2023.01.023
Journal of Thrombosis and Haemostasis : JTH; Palma-Barqueros V, Bastida JM et. al.

Feb 4th, 2023 - Germline mutations in RUNX1 can cause a familial platelet disorder predisposing to acute myeloid leukemia, an autosomal dominant disorder characterized by moderate thrombocytopenia, platelet dysfunction, and high risk of developing acute myeloid leukemia or myelodysplastic syndrome. Discerning the pathogenicity of novel RUNX1 variants is critical for patient management. To extend the characteri...

Provider- and Facility-Level Variation in Pre-Cancerous Cervical Biopsy Diagnoses.
https://doi.org/10.1097/LGT.0000000000000721
Journal of Lower Genital Tract Disease; Del Vecchio NJ, Beaber EF et. al.

Feb 3rd, 2023 - Reproducibility of cervical biopsy diagnoses is low and may vary based on where the diagnostic test is performed and by whom. Our objective was to measure multilevel variation in diagnoses across colposcopists, pathologists, and laboratory facilities. We cross-sectionally examined variation in cervical biopsy diagnoses within the 5 sites of the Population-Based Research Optimizing Screening thr...

AUTOMATED IN VIVO HIGH-RESOLUTION IMAGING TO DETECT HPV-ASSOCIATED ANAL PRECANCER IN PE...
https://doi.org/10.14309/ctg.0000000000000558
Clinical and Translational Gastroenterology; Brenes D, Kortum A et. al.

Feb 3rd, 2023 - In the United States, the effectiveness of anal cancer screening programs has been limited by a lack of trained professionals proficient in high-resolution anoscopy (HRA) and a high patient lost-to-follow-up rate between diagnosis and treatment. Simplifying anal interepithelial neoplasia grade 2 or more severe (AIN 2+) detection could radically improve the access and efficiency of anal cancer p...

The Thyroid Pathologist Meets Therapeutic Pharmacology.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890439
Endocrine Pathology; Sande CM, Tondi Resta I et. al.

Feb 2nd, 2023 - The effects of many pharmacological agents on thyroid function are well known. Direct influences on measurements of thyroid function tests are also described. However, certain classes of drugs produce morphological changes in the gland. This review focuses on the significance of the following drug classes for the thyroid pathologist: iodine, antithyroid drugs, psychotropic drugs, antibiotics, c...

Developing H3K27M mutant selective radiosensitization strategies in diffuse intrinsic p...
https://doi.org/10.1016/j.neo.2023.100881
Neoplasia (New York, N.Y.); Parsels LA, Wahl DR et. al.

Feb 2nd, 2023 - Diffuse intrinsic pontine glioma (DIPG) is a rare but highly lethal pediatric and adolescent tumor located in the pons of the brainstem. DIPGs harbor unique and specific pathological and molecular alterations, such as the hallmark lysine 27-to-methionine (H3K27M) mutation in histone H3, which lead to global changes in the epigenetic landscape and drive tumorigenesis. While fractionated radiothe...

Cd34 Immunostaining Adds Specificity To Microvascular invasion Analysis in Hepatocellul...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879024
Journal of Hepatocellular Carcinoma; Gama H, Albuquerque R et. al.

Jan 31st, 2023 - Hepatocellular carcinoma is the most common primary neoplasia of the liver. Microvascular invasion predicts outcome and defines tumor staging. However, its diagnosis is still a challenge. The present study aims to evaluate inter and intraobserver agreement in identifying the presence of microvascular invasion using conventional and immunohistochemistry histology. Three pathologists performed th...

Mutational landscape of normal human skin: clues to understanding early-stage carcinoge...
https://doi.org/10.1016/j.jid.2023.01.006
The Journal of Investigative Dermatology; Kim YS, Bang CH et. al.

Jan 31st, 2023 - Normal skin contains numerous clones carrying cancer driver mutations. However, the mutational landscape of normal skin and its clonal relationship with skin cancer requires further elucidation. The aim of our study was to investigate the mutational landscape of normal human skin. We performed whole-exome sequencing using physiologically normal skin tissues and the matched peripheral blood (n =...

The gut microbiome, short chain fatty acids, and related metabolites in cystic fibrosis...
https://doi.org/10.1016/j.jcf.2023.01.013
Journal of Cystic Fibrosis : Official Journal of the Euro... Baldwin-Hunter BL, Rozenberg FD et. al.

Jan 31st, 2023 - Adults with cystic fibrosis (CF) are at increased risk for colon cancer. CF patients have reductions in intestinal bacteria that produce short chain fatty acids (SCFAs), although it is unclear whether this corresponds with intestinal SCFA levels and the presence of colonic neoplasia. The aim of this study was to compare gut microbiome and SCFA composition in patients with and without CF, and to...

Past, present and future of Focused Ultrasound as an adjunct or complement to DIPG/DMG ...
https://doi.org/10.1016/j.neo.2023.100876
Neoplasia (New York, N.Y.); Parekh K, LeBlang S et. al.

Jan 30th, 2023 - Diffuse Intrinsic Pontine Glioma (DIPG), now known as Diffuse Midline Glioma (DMG) is a devastating pediatric brain tumor with limited treatment options and a very poor prognosis. Despite more than 250 clinical trials aimed to treat children diagnosed with DMG, no curative therapies currently exist for this patient population. A major obstacle has been the intact blood brain barrier (BBB) which...

Presentation, medical complications and development of gestational trophoblastic neopla...
https://doi.org/10.1016/j.ygyno.2023.01.016
Gynecologic Oncology; Braga A, Andrade T et. al.

Jan 28th, 2023 - To describe the natural history of hydatidiform mole (HM) after intracytoplasmic sperm injection (ICSI), emphasizing the clinical and oncological outcomes, as compared to patients who had HM after spontaneous conception (SC). Retrospective historical cohort study of patients with HM followed at the Rio de Janeiro Federal University, from January 1st 2000-December 31st 2020. Comparing singleton ...

Robot-assisted TAMIS: a systematic review of feasibility and outcomes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882737
Surgical Endoscopy; Jakobsen PCH, Krarup PM et. al.

Jan 28th, 2023 - In the advancement of transanal local excision, robot-assisted transanal minimal invasive surgery is the newest development. In the confined area of the rectum, robot-assisted surgery should, theoretically, be superior due to articulated utensils, video enhancement, and tremor reduction, however, this has not yet been investigated. The aim of this study was to review the evidence reported to-da...

KRAS G12D mutation in Brunner gland adenoma.
https://doi.org/10.1136/bcr-2022-252160
BMJ Case Reports; Ortega M, Sparks J et. al.

Jan 28th, 2023 - Brunner gland lesions (BGLs) encompass benign proliferations of the homonymous glands and have been designated as hyperplasia, adenoma (BGA), hamartoma or nodule. In general terms, lesions larger than 0.5 cm are considered true neoplasia with unknown malignant potential and unclear pathogenesis. Genetic alterations have seldom been reported in BGL, and include SMAD4/DPC4 and LRIG1, but not KRAS...

Cheek Reconstruction Procedures
http://emedicine.medscape.com/article/877383-overview

Jan 27th, 2023 - History of the Procedure Formalized knowledge of facial reconstruction has been present since the last millennium. The Byzantine physician Oribasius first described procedures for facial reconstruction in the fourth century. The Synagogae Medicae, a 70-volume medical encyclopedia written by Oribasius, describes the principles of basic advancement flaps for brow, nasal, and auricular defects. In...

FLCN-Driven Functional Adrenal Cortical Carcinoma with High Mitotic Tumor Grade: Extend...
https://doi.org/10.1007/s12022-023-09748-2
Endocrine Pathology; Hofstedter R, Sanabria-Salas MC et. al.

Jan 27th, 2023 - Adrenal cortical carcinoma is an aggressive and rare malignancy of steroidogenic cells of the adrenal gland. Most adult adrenal cortical carcinomas are sporadic, but a small fraction may be associated with inherited tumor syndromes, such as Li-Fraumeni, multiple endocrine neoplasia 1, Lynch syndrome, and Beckwith-Wiedemann syndrome, as well as isolated case reports of non-syndromic manifestatio...

Risk of total metachronous advanced neoplasia at surveillance colonoscopy after detecti...
https://doi.org/10.1055/a-2020-6797
Endoscopy Djinbachian R, Lafontaine ML et. al.

Jan 27th, 2023 - Serrated lesions (SLs), including sessile serrated lesions (SSL) and traditional serrated adenomas (TSA) have become subject of increased interest for their role as CRC precursors. Primary aim was to evaluate the presence of total metachronous advanced neoplasia (T-MAN) at follow-up in patients with index SL compared to a matched cohort without SL. Patients 45-74y with SLs were matched 2:1 by s...

Myeloid/lymphoid neoplasm with eosinophilia and BCR/FGFR1 rearrangement with transforma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878768
Journal of Medical Case Reports; Isaza AP, Quintero SC et. al.

Jan 27th, 2023 - Myeloproliferative neoplasms are a group of diseases with diverse biological and clinical characteristics. As a provisional separate entity, myeloid/lymphoid neoplasms with eosinophilia and genetic rearrangement have been described, which may present an initial clinical behavior of myeloproliferation and be characterized by varied genetic rearrangements. One of these entities is associated with...

Cheek Reconstruction Procedures
https://emedicine.medscape.com/article/877383-overview

Jan 27th, 2023 - History of the Procedure Formalized knowledge of facial reconstruction has been present since the last millennium. The Byzantine physician Oribasius first described procedures for facial reconstruction in the fourth century. The Synagogae Medicae, a 70-volume medical encyclopedia written by Oribasius, describes the principles of basic advancement flaps for brow, nasal, and auricular defects. In...

Cheek Reconstruction Procedures
https://emedicine.medscape.com/article/877383-print

Jan 27th, 2023 - History of the Procedure Formalized knowledge of facial reconstruction has been present since the last millennium. The Byzantine physician Oribasius first described procedures for facial reconstruction in the fourth century. The Synagogae Medicae, a 70-volume medical encyclopedia written by Oribasius, describes the principles of basic advancement flaps for brow, nasal, and auricular defects. In...