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About 51,200 results

Association Between Human Papillomavirus Infection Among Pregnant Women and Preterm Birth.
https://doi.org/10.1001/jamanetworkopen.2021.25308
JAMA Network Open; Niyibizi J, Mayrand MH et. al.

Sep 16th, 2021 - Preterm birth remains a leading cause of perinatal mortality and lifelong morbidity worldwide. The cause of most preterm births is unknown, although several infectious processes have been implicated. To assess whether human papillomavirus (HPV) infection, a frequent infection among women of childbearing age, is associated with preterm birth. The prospective HERITAGE cohort study was conducted a...

Non-thermal Resection Device for Ablation of Barrett's Esophagus - a Feasibility and Sa...
https://doi.org/10.1055/a-1644-4326
Endoscopy Gotink AW, Peters Y et. al.

Sep 15th, 2021 - Background and study aims Several techniques exist for the eradication of Barrett's esophagus (BE); however, all have limitations regarding successful conversion to squamous epithelium and a complication profile. We aimed to assess the feasibility and safety of a new non-thermal device, the EndoRotor, for the eradication of BE as a first-line ablation technique. Patients and methods Patients wi...

BCL2 translocation in high grade B cell lymphoma (NOS, DH/TH) is associated with reduce...
https://doi.org/10.1080/10428194.2021.1975189
Leukemia & Lymphoma; Gonzalez de Villambrosia S, Bastos M et. al.

Sep 14th, 2021 - High Grade B Cell Lymphoma, NOS, and High Grade B Cell Lymphoma with Dual Hit or Triple Hit have been recently recategorized in the 2016 revision of the WHO classification of lymphoid neoplasms. In this study we have characterized the genetic, histopathological, and clinical features of a series of this type of lymphoid neoplasia (17 HGBCL NOS and 53 HGBCL DH/TH).HGBCL NOS showed better respons...

Validity of Secretin Stimulation Testing on Proton Pump Inhibitor Therapy for Diagnosis...
https://doi.org/10.14309/ajg.0000000000001487
The American Journal of Gastroenterology; Bhattacharya S, Blau JE et. al.

Sep 14th, 2021 - Zollinger-Ellison syndrome (ZES) is characterized by gastrinoma-induced hypergastrinemia causing excessive gastric acid secretion. Secretin stimulation tests (SSTs) are required for diagnosis in the majority of patients. Two case reports suggest that proton pump inhibitors (PPIs) cause false SST results. Consequently, PPIs are discontinued to allow hyperchlorhydria to recur; however, uncontroll...

Two Distinct Classes of Thymic Tumors in Patients with MEN1 Show LOH at the MEN1 Locus.
https://doi.org/10.1530/ERC-21-0226
Endocrine-related Cancer; Mandl A, Welch JM et. al.

Sep 14th, 2021 - Patients with the multiple endocrine neoplasia type 1 (MEN1) syndrome carry germline heterozygous loss-of-function mutations in the MEN1 gene which predisposes them to the development of various endocrine and non-endocrine tumors. Over 90% of these tumors have been shown to undergo biallelic inactivation of the MEN1 tumor suppressor gene by somatic loss of the wild-type allele resulting in loss...

Parathyroid disorder and concomitant thyroid cancer in patients with multiple endocrine...
https://doi.org/10.1097/MD.0000000000027098
Medicine Wang Y, Cai S et. al.

Sep 14th, 2021 - This study aimed to determine the rates and characteristics of parathyroid disorder and thyroid cancer in patients with multiple endocrine neoplasia type 1 vs sporadic primary hyperparathyroidism (SPHP) undergoing parathyroidectomy.Patients with multiple endocrine neoplasia type 1-associated primary hyperparathyroidism (MPHP) or SPHP who underwent initial or reoperative parathyroid exploration ...

Alloplastic Temporomandibular Joint Reconstruction Following Recurrent Ameloblastoma Re...
https://doi.org/10.1097/SCS.0000000000008124
The Journal of Craniofacial Surgery; Horen SR, Hansdorfer MA et. al.

Sep 13th, 2021 - Ameloblastomas are benign tumors that most commonly affecting the mandible. The current standard of treatment for ameloblastomas is resection followed by reconstruction that has historically been accomplished through the use of a microsurgical vascularized flaps taken from the iliac crest or fibula. Alloplastic reconstruction methods have gained popularity over recent years with success reporte...

SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT pat...
https://doi.org/10.1016/j.neo.2021.08.002
Neoplasia (New York, N.Y.); Luo Z, Wang J et. al.

Sep 13th, 2021 - The E3 ubiquitin ligase adaptor Speckle-type POZ protein (SPOP) plays an important tumour suppressor role in prostate cancers (PCa), with mutation rate up to 15%. However, how SPOP mutations regulate prostate tumorigenesis remains elusive. Here, we report the identification of cell division cycle associated 5 (CDCA5) as a SPOP substrate. We found that SPOP interacts with CDCA5 and promotes its ...

Incidental diagnosis of serrated polyp in the appendix warrants colonoscopy to screen f...
https://doi.org/10.1093/bjs/znab305
The British Journal of Surgery; van Herwaarden YJ, Madani A et. al.

Sep 12th, 2021 - Incidental diagnosis of serrated polyp in the appendix warrants colonoscopy to screen for colorectal neoplasia.|2021|van Herwaarden YJ,Madani A,van der Post RS,Lemmens VEPP,Nagtegaal ID,|

Risk Assessment of Human Papillomavirus-Positive Cytology-Negative Cervical Cancer Scre...
https://doi.org/10.1093/ajcp/aqab129
American Journal of Clinical Pathology; Miller DL, Graham A et. al.

Sep 12th, 2021 - As we move toward human papillomavirus (HPV) only as the preferred cervical cancer screening method, we performed a retrospective analysis of Black and White women with negative cytology (Papanicolaou negative [PAPneg]) and positive high-risk HPV (hrHPV) (HPVpos) results and determined follow-up. We searched our pathology data system for patients with PAPneg/HPVpos results (2017-2019). Follow-u...

Efficacy and Safety of Regimens Used for the Treatment of POEMS Syndrome- A Systematic ...
https://doi.org/10.1016/j.clml.2021.07.033
Clinical Lymphoma, Myeloma & Leukemia; Faizan U, Sana MK et. al.

Sep 12th, 2021 - POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy/edema, monoclonal plasma protein [M protein], and skin changes) is a rare paraneoplastic disorder associated with underlying plasma cell neoplasia. Although limited-stage disease can be treated with radiotherapy, treatment for the more advanced disease remains unclear. The most commonly used therapies for POEMS syndrome include alkyla...

Cervicovaginal Microbiome after Cervical Intraepithelial Neoplasia Treatment. A Protoco...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431715
International Journal of Environmental Research and Publi... Janicka-Kośnik M, Sarecka-Hujar B et. al.

Sep 11th, 2021 - (1) Background: The microbiome consists of microorganisms from various kingdoms with numerous physical and chemical properties Lactobacillus species constitute the highest percentage of healthy cervical and vaginal microbiota. Dysbiosis may cause adverse outcomes, e.g., bacterial vaginosis, pelvic inflammatory disease and pregnancy complications. The cervicovaginal microbiome might contribute t...

68 Ga-DOTATATE PET/CT imaging in endogenous hyperinsulinemic hypoglycemia: A tertiary e...
https://doi.org/10.1111/cen.14586
Clinical Endocrinology; Shah R, Sehemby M et. al.

Sep 10th, 2021 - Literature regarding utility of 68 Ga-DOTATATE PET/CT in insulinoma localization across various subgroups [benign/malignant/multiple endocrine neoplasia-1 (MEN-1) syndrome associated] remains scarce. In this study, the performance of 68 Ga-DOTATATE PET/CT was compared with contrast-enhanced computed tomography (CECT) and 68 Ga-NODAGA-Exendin-4 PET/CT (whenever available) in an endogenous hyperi...

Prediction of the severity of colorectal lesion by fecal hemoglobin concentration obser...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384754
World Journal of Gastroenterology; Balamou C, Koïvogui A et. al.

Sep 10th, 2021 - The rate of positive tests using fecal immunochemical test (FIT) does not decrease with subsequent campaigns, but the positive predictive value of advanced neoplasia significantly decreases in subsequent campaign after a first negative test. A relationship between the fecal hemoglobin concentration (Fhb) and the opportunity to detect a colorectal cancer in subsequent campaign has been shown. To...

Metachronous second primary neoplasia in oropharyngeal cancer patients: Impact of tumor...
https://doi.org/10.1016/j.oraloncology.2021.105503
Oral Oncology; Milliet F, Bozec A et. al.

Sep 10th, 2021 - Patients with oropharyngeal squamous cell carcinoma (OPSCC) display a significant risk to develop a metachronous second primary neoplasia (MSPN). HPV and non-HPV-related OPSCC are 2 distinct entities with biological, clinical and prognostic differences. The aims of our study were to analyze the impact of tumor HPV status and other relevant clinical factors, such as tobacco and/or alcohol (T/A) ...

Cell competition, cooperation, and cancer.
https://doi.org/10.1016/j.neo.2021.08.001
Neoplasia (New York, N.Y.); Marongiu F, Cheri S et. al.

Sep 10th, 2021 - Complex multicellular organisms require quantitative and qualitative assessments on each of their constitutive cell types to ensure coordinated and cooperative behavior towards overall functional proficiency. Cell competition represents one of the operating arms of such quality control mechanisms and relies on fitness comparison among individual cells. However, what is exactly included in the f...

Improved long-term survival of corpus cancer in Japan: A 40-year population-based analy...
https://doi.org/10.1002/ijc.33799
International Journal of Cancer; Yagi A, Ueda Y et. al.

Sep 9th, 2021 - The incidence of uterine corpus cancer has been increasing globally due to increase in obesity. However, a detailed analysis of long-term epidemiological trends of corpus cancer in Japan, where obesity is relatively minimal, has not been conducted. In this retrospective, population-based study using the Osaka Cancer Registry, we analyzed 15 255 cases of corpus neoplasia registered between 1977 ...

Mediastinal ectopic thyroid tissue, an imitator of an enlarged lymph node with metastat...
https://doi.org/10.1002/dc.24866
Diagnostic Cytopathology; Tsai A, Rafferty W et. al.

Sep 8th, 2021 - The prevalence of ectopic thyroid tissue, based on autopsy studies, is between 7% and 10%, but there are rare cases reported in the thoracic region. Here, we encountered a case of thoracic ectopic thyroid tissue presenting as a presumed enlarged mediastinal lymph node. A 50-year-old female with a history of lung adenocarcinoma, status post resection, presented with complaints of headache, dizzi...

Association study of relationships of polymorphisms in the miR-21, miR-26b, miR-221/222...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422721
BMC Cancer; Yang J, Yan Z et. al.

Sep 8th, 2021 - miR-21, miR-26b, miR-221/222 and miR-126 play crucial roles in cervical cancer development. Studies have shown that polymorphisms in miRNA genes can affect miRNA expression, which might be associated with cancer development. Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, ...

Maslinic Acid Inhibits Cervical Intraepithelial Neoplasia by Suppressing Interleukin-6 ...
https://doi.org/10.2174/1871520621666210903143922
Anti-cancer Agents in Medicinal Chemistry; Chen J, Wang L

Sep 4th, 2021 - Cervical intraepithelial neoplasia (CIN) directly precedes cervical cancer, and elevated proinflammatory cytokine interleukins (IL)-6 is implicated in CIN. As maslinic acid exhibits anti-IL-6 property, the present study sought to determine the effect of maslinic acid on CIN in vitro and in vivo using cell cultures and mouse CIN models, respectively. The dose-effect of maslinic acid on HeLa cell...