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About 54,143 results

Concurrent anorectal and cervical cytology in women with positive and negative Pap test...
https://doi.org/10.1002/ijgo.14490
International Journal of Gynaecology and Obstetrics: the ... Tehranian A, Ghahghaei-Nezamabadi A et. al.

Oct 3rd, 2022 - Considering the exponentially growing concerns about the increase of anal cancer rates in women with human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN), we evaluated concurrent anorectal and cervical cytology in women with positive and negative Pap tests. This study was designed as a cross-sectional study, and it was conducted in Arash women's hospital, Tehran, Ir...

LncRNA TMEM147-AS1/miR-133b/ZNF587 axis regulates Warburg effect and promotes prostatic...
https://doi.org/10.1002/jgm.3453
The Journal of Gene Medicine; Wu T, Han N et. al.

Oct 2nd, 2022 - Warburg effect is a characteristic tumor cell behavior regarded as one of the cancer hallmarks and promotes tumor progression by promoting glucose uptake and lactate production. Long non-coding RNAs (lncRNAs) had been reported to emerge as a vital function in cancer development. The present research is designed to investigate the underlying molecular mechanism of lncRNA TMEM147 antisense RNA 1 ...

Biology and management of lobular endocervical glandular hyperplasia.
https://doi.org/10.1111/jog.15441
The Journal of Obstetrics and Gynaecology Research; Miyamoto T, Kobara H et. al.

Oct 1st, 2022 - Lobular endocervical glandular hyperplasia (LEGH) is a multicystic proliferative disorder of the uterine cervix. The aim of this review was to clarify the current understanding of this unique tumor. This article reviews the chronological progress of research regarding clinico-pathological and genetic aspects of LEGH and related cervical cystic diseases such as Nabothian cyst and adenocarcinoma ...

Genetic Dissection of Primary Aldosteronism in a Patient with MEN1 and Ipsilateral Adre...
https://doi.org/10.1210/clinem/dgac564
The Journal of Clinical Endocrinology and Metabolism; Salle SP, Corbeil G et. al.

Oct 1st, 2022 - Adrenal tumors are found in up to 40% of patients with multiple endocrine neoplasia type 1 (MEN1). However, adrenocortical carcinomas (ACC) and primary aldosteronism (PA) are rare in MEN1. A 48-year-old woman known for primary hyperparathyroidism and hypertension with hypokalemia was referred for a right complex 8 cm adrenal mass with a 38.1 SUVmax uptake on 18F-FDG PET/CT. PA was confirmed by ...

Engineered Hybrid Treg-Targeted Nanosomes Restrain Lung Immunosuppression by Inducing I...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512414
International Journal of Nanomedicine; Domvri K, Petanidis S et. al.

Sep 30th, 2022 - Tumor immunotherapy is a key therapeutic paradigm for the treatment of several malignancies. However, in metastatic lung cancer, classical immunotherapy regimes are ineffective due to regulatory T cell (Treg)-related immunosuppression and tumor relapse. To address this issue, we designed specific biocompatible Treg-targeted nanocarriers (NCs) as a model of immune-based nanotherapy, in order to ...

Transcription factor SOX3 upregulated pro-apoptotic genes expression in human breast ca...
https://doi.org/10.1007/s12032-022-01758-0
Medical Oncology (Northwood, London, England); Silva FHS, Underwood A et. al.

Sep 30th, 2022 - Sex-determining region Y-box 3 (SOX3) protein, a SOX transcriptions factors group, has been identified as a key regulator in several diseases, including cancer. Downregulation of transcriptions factors in invasive ductal carcinoma (IDC) can interfere in neoplasia development, increasing its aggressiveness. We investigated SOX3 protein expression and its correlation with apoptosis in the MDA-MB-...

The seminal plasma microbiome of men with testicular germ cell tumours described by sma...
https://doi.org/10.1111/andr.13305
Andrology Mørup N, Main AM et. al.

Sep 29th, 2022 - It has been estimated that microorganisms are involved in the pathogenesis of approximately 20% of all cancers. Testicular germ cell tumours (TGCTs) are the most common type of malignancy in young men and arise from the precursor cell, Germ Cell Neoplasia in Situ (GCNIS). The microbiome of seminal plasma and testicular tissue has not been thoroughly investigated in regard to TGCTs. To investiga...

Sporadic, Non-Functional, Gastrin-Producing Duodenal Neuroendocrine Tumors: A Retrospec...
https://doi.org/10.1111/1751-2980.13129
Journal of Digestive Diseases; De Jorge Huerta L, Solares Fernández I et. al.

Sep 29th, 2022 - non-functioning gastrin-producing Neuroendocrine Neoplasms (NEN) of the duodenum are rare tumors of the gastrointestinal tract without a clinical syndrome due to gastrin-production. Their incidence has significantly increased in the last few years especially as an incidental finding during endoscopic studies. The aim of this study is to describe the characteristics of this emergent neoplasm, to...

Differential impact of PI3K/AKT/mTOR signaling on tumor initiation and progression in a...
https://doi.org/10.1002/pros.24441
The Prostate; Wang S, Zhang C et. al.

Sep 28th, 2022 - The PI3K/AKT/mTOR signaling pathway is essential for initiation and progression of prostate cancer. However, there has been no a comprehensive comparison for the role of these signaling nodes in prostate tumor initiation and progression. With genetically engineered animal models, we compared the impact of prostate-specific deletions of Pten, Tsc1, and Tsc2 and activation of Akt1 on tumor initia...

Real-time colorectal polyp detection using a novel computer-aided detection system (CAD...
https://doi.org/10.1007/s00384-022-04258-9
International Journal of Colorectal Disease; Soons E, Rath T et. al.

Sep 28th, 2022 - Colonoscopy aims to early detect and remove precancerous colorectal polyps, thereby preventing development of colorectal cancer (CRC). Recently, computer-aided detection (CADe) systems have been developed to assist endoscopists in polyp detection during colonoscopy. The aim of this study was to investigate feasibility and safety of a novel CADe system during real-time colonoscopy in three Europ...

ABCL-297 Hemophagocytic Lymphohistiocytosis Singularity: A Multicenter Retrospective St...
https://doi.org/10.1016/S2152-2650(22)01523-3
Clinical Lymphoma, Myeloma & Leukemia; Hernández-Sánchez A, Cerezo-Martín JM et. al.

Sep 28th, 2022 - Hemophagocytic lymphohistiocytosis (HLH) is characterized by an excessive inflammatory response due to aberrant activation of macrophages and T lymphocytes. Cases of primary HLH (genetic mutations) are usually diagnosed in childhood, while secondary cases (due to neoplasms or infections, among others) appear predominantly in adults. Early diagnosis and treatment are essential to reduce the high...

MDS-287 Genetic Landscape of Somatic Myeloid Mutations in the Presence of Rare TERT Var...
https://doi.org/10.1016/S2152-2650(22)01404-5
Clinical Lymphoma, Myeloma & Leukemia; Ferrer A, Mangaonkar AM et. al.

Sep 28th, 2022 - Germline variants in the TERT gene may lead to impaired telomere maintenance implicated in the pathogenesis of myelodysplastic syndromes (MDS) by unknown mechanisms. To explore the clinical and genetic associations of germline TERT variants in patients with suspicion of myeloid neoplasm. We selected patients tested through our institutional amplicon-based sequencing panel (42 myeloid genes, inc...

MPN-076 Impact of Comorbidities and Response to Treatment on the MPN SAF Assessment of ...
https://doi.org/10.1016/S2152-2650(22)01434-3
Clinical Lymphoma, Myeloma & Leukemia; Ramdoun A, Hadjeb A et. al.

Sep 28th, 2022 - Philadelphia chromosome-negative myelopro-liferative neoplasms (MPN) are a heterogeneous group of hematological malignancies including essential thrombocythemia (ET), polycythemia (PV), and primary myelofibrosis (PMF). The MPN Symptom Assessment Form (SAF), or MPN 10, questionnaire is a validated tool for assessing the symptoms presented by patients with MPN and their evolution during treatment...

Colon mucus in colorectal neoplasia and beyond.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476883
World Journal of Gastroenterology; Loktionov A

Sep 27th, 2022 - Little was known about mammalian colon mucus (CM) until the beginning of the 21st century. Since that time considerable progress has been made in basic research addressing CM structure and functions. Human CM is formed by two distinct layers composed of gel-forming glycosylated mucins that are permanently secreted by goblet cells of the colonic epithelium. The inner layer is dense and impenetra...

Frequency and impact of musculoskeletal symptoms on quality of life in MEN2B.
https://doi.org/10.1111/cen.14823
Clinical Endocrinology; Henderson JW, Montebello A et. al.

Sep 27th, 2022 - To investigate the impact of musculoskeletal (MSK) related symptoms on the quality of life of patients with MEN2B. An online survey was distributed by the Association for Multiple Endocrine Neoplasia Disorders (AMEND) to their members and worldwide via a social media group for MEN2B patients. The survey consisted of a detailed questionnaire analysing the MSK related symptoms and structural defo...

Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of c...
https://doi.org/10.1016/j.neo.2022.100837
Neoplasia (New York, N.Y.); Ha DP, Huang B et. al.

Sep 27th, 2022 - KRAS is the most commonly mutated oncogene in human cancers with limited therapeutic options, thus there is a critical need to identify novel targets and inhibiting agents. The 78-kDa glucose-regulated protein GRP78, which is upregulated in KRAS cancers, is an essential chaperone and the master regulator of the unfolded protein response (UPR). Following up on our recent discoveries that GRP78 h...

Colorectal Cancer Screening in a Changing World.
https://doi.org/10.1016/j.gtc.2022.05.002
Gastroenterology Clinics of North America; Bresalier RS

Sep 25th, 2022 - Early detection of colorectal neoplasia significantly reduces mortality from colorectal cancer (CRC), and numerous screening options exist. Guidelines for CRC screening from US and international professional societies provide menus of options based on strength of evidence. Despite availability of screening and its proven impact, 40% of guideline-eligible patients are not screened as recommended...

Management of Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma.
https://doi.org/10.1016/j.gtc.2022.06.004
Gastroenterology Clinics of North America; Cotton CC, Eluri S et. al.

Sep 25th, 2022 - While patients with Barrett's esophagus without dysplasia may benefit from endoscopic surveillance, those with low-grade dysplasia may be managed with either endoscopic surveillance or endoscopic eradication. Patients with Barrett's esophagus with high-grade dysplasia and/or intramucosal adenocarcinoma will generally require endoscopic eradication therapy. The management of Barrett's esophagus ...

Cancer in Inflammatory Bowel Disease.
https://doi.org/10.1016/j.gtc.2022.05.003
Gastroenterology Clinics of North America; Faye AS, Holmer AK et. al.

Sep 25th, 2022 - Inflammatory bowel diseases (IBD), including Crohn disease and ulcerative colitis, are chronic inflammatory conditions of the gastrointestinal tract. Individuals with IBD are at increased risk for several malignancies originating in the intestine, such as colorectal cancer, small bowel adenocarcinoma, intestinal lymphoma, and anal cancer. There are also several extraintestinal malignancies asso...

Gestational exposure to erenumab-The outcome of three pregnancies.
https://doi.org/10.1111/head.14393
Headache Bonifácio GV, de Carvalho SC et. al.

Sep 25th, 2022 - Erenumab is a monoclonal antibody (mAb) approved for the preventive treatment of migraine. While preclinical studies on calcitonin gene-related peptide mAbs did not identify any reproductive toxicity, pregnant and breastfeeding women were excluded from the pivotal human studies, and therefore the safety of calcitonin gene-related peptide medications in this population must be studied. So far, p...